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Articles 42271 - 42300 of 42307
Full-Text Articles in Entire DC Network
Anything But Endo: Diagnostic Buck-Passing In Endometriosis Diagnosis, Rita Dexter, Megan Kitts, Heather Welty, Melanie Jeske
Anything But Endo: Diagnostic Buck-Passing In Endometriosis Diagnosis, Rita Dexter, Megan Kitts, Heather Welty, Melanie Jeske
Center for Medical Ethics and Health Policy Staff Publications
People living with endometriosis, a disease in which tissue similar to the lining of the uterus grows elsewhere in the body, often experience prolonged diagnostic journeys because of symptom variability, normalisation of period pain and other symptoms, and lack of awareness of the condition. In this article, we analyse the endometriosis diagnostic journey through the lens of epistemic injustice. Drawing on in-depth interviews with 52 people living with endometriosis in the United States, we introduce the concept of diagnostic buck-passing to characterise the phenomenon wherein individuals who seek treatment for their symptoms end up stuck in a cycle of seeing …
Can I Get A Witness? The Ethical Dimensions Of Family Presence In Patient Suffering, Jennifer Blumenthal-Barby, Trevor M Bibler, Holland Kaplan, Adam Omelianchuk, Joanna Smolenski
Can I Get A Witness? The Ethical Dimensions Of Family Presence In Patient Suffering, Jennifer Blumenthal-Barby, Trevor M Bibler, Holland Kaplan, Adam Omelianchuk, Joanna Smolenski
Center for Medical Ethics and Health Policy Staff Publications
For patients who are suffering, the bedside presence of a family member can provide comfort, and many people hold that there is moral value in being present with a conscious, suffering patient. Yet what is the moral significance of the absence of family members when a patient is minimally conscious or unconscious and not aware of their absence? Clinicians are often troubled when family members and surrogate decision-makers who are able to spend a significant amount of time at an unconscious, seriously ill patient's bedside do not do so. Clinicians feel frustrated that they must bear the burden of witnessing …
Toward Ethical Provenance Tracking: The Ga4gh Model Data Access Agreement (Daa), Alexander Bernier, Bartha Maria Knoppers, Jonathan Lawson, Robyn Mcdougall, Maili Raven-Adams, Vasiliki Rahimzadeh
Toward Ethical Provenance Tracking: The Ga4gh Model Data Access Agreement (Daa), Alexander Bernier, Bartha Maria Knoppers, Jonathan Lawson, Robyn Mcdougall, Maili Raven-Adams, Vasiliki Rahimzadeh
Center for Medical Ethics and Health Policy Staff Publications
Purpose: Standardizing contractual clauses that govern data access enables research institutions to responsibly steward genomic and related health data while enabling its efficient downstream reuse.
Methods: We describe a document analysis study using both qualitative and comparative law analytical approaches to identify the most common categories of clauses from 29 different data access agreements used by human biomedical research consortia globally. We furthermore characterized the legal positions and standard practices for each common element of the agreement and synthesized across them to develop model clauses. A total of 3 discussion sessions were organized virtually to refine the clauses among members …
Sewers To Solutions: A Guide To Wastewater Pathogen Monitoring
Sewers To Solutions: A Guide To Wastewater Pathogen Monitoring
Faculty, Staff and Students Publications
Wastewater-based epidemiology (WBE) is the analysis of wastewater to detect pathogen levels or activity for public health awareness or action. Pioneered in the 1940s, WBE underwent a resurgence during the COVID-19 pandemic, providing important information about number of cases, outbreaks, and seasonal impact. With advancements in detection technologies and growing interest in environmental surveillance, WBE is poised to become a standard practice in public health monitoring. Here, we provide an overview of the current state of the art of pathogen WBE, including methods of molecular detection, analysis of wastewater data, real-world applications and programs, public health interventions, and benefits and …
Helicobacter Pylori And Cancer: What's The Link?, Maria Pina Dore
Helicobacter Pylori And Cancer: What's The Link?, Maria Pina Dore
Faculty, Staff and Students Publications
Helicobacter pylori (H. pylori) is a human bacterial pathogen that causes one of the most common chronic bacterial infections worldwide. The microorganism has been classified by the International Agency for Research on Cancer as a Group I carcinogen. While the etiological link to gastric cancer is well established, the precise molecular and cellular mechanisms driving this transformation are highly complex and incompletely understood. Fundamentally, the infection results from the chronic presence of acute on chronic gastric mucosal inflammation. H. pylori pathogenicity is increased by bacterial virulence factors including the cytotoxin-associated gene A (CagA) and Vacuolating cytotoxin A (VacA) …
Effect Of Graphene Oxide On The Upconversion Photoluminescence Behavior Of Er/Yb Co-Doped Pvdf-Go Composite Nanofibers, Saptasree Bose, Jack Ryan Summers, Bhupendra B. Srivastava, Karen Lozano, Victoria Padilla-Gainza
Effect Of Graphene Oxide On The Upconversion Photoluminescence Behavior Of Er/Yb Co-Doped Pvdf-Go Composite Nanofibers, Saptasree Bose, Jack Ryan Summers, Bhupendra B. Srivastava, Karen Lozano, Victoria Padilla-Gainza
Mechanical Engineering Faculty Publications
Upconversion photoluminescence (UCPL) materials, particularly rare-earth (RE) doped nanoparticles, have garnered significant attention due to their ability to convert near-infrared (NIR) excitation into visible emission, offering benefits such as high photostability, long lifetimes, low autofluorescence, and deep tissue penetration. Among various platforms, polymer-based one-dimensional (1D) nanofibers with in-situ lanthanide doping remain relatively unexplored, despite their superior mechanical flexibility, processability, and potential for improved luminescence performance. In this study, we report the fabrication and UCPL quenching behavior of Er3+/Yb3+ co-doped polyvinylidene difluoride (PVDF) nanofibers incorporated with graphene oxide (GO), synthesized for the first time using the scalable Forcespinning® technique. PVDF, a …
Hypothyroidism Is Associated With Higher Healthcare Utilisation And Higher Need For Blood Transfusion After Primary Total Knee Arthroplasty (Tka) In Patients With Osteoarthritis: A National Inpatient Sample Analysis
Faculty, Staff and Students Publications
Purpose: To examine the association of hypothyroidism with primary total knee arthroplasty (TKA) outcomes in adults with primary underlying diagnosis of osteoarthritis (OA).
Methods: We identified a prospective cohort of patients in the 2016-2020 national inpatient sample (NIS) that received primary TKA with an underlying diagnosis of OA, identified using International Classification of Diseases, Tenth Revision, Common Modification (ICD-10-CM) and Procedure Coding System (ICD-10-PCS) codes in the primary procedure and diagnosis positions, respectively. We performed multivariable-adjusted regression analyses for healthcare utilisation (length of hospital stay, hospital charges and discharge destination) and clinical outcomes (blood transfusion; prosthetic fracture, dislocation or infection; …
Surface Marker Identification To Capture Live Circulating Tumor Cells In Metastatic Triple-Negative Breast Cancer, Ping Gong, Michael T Lewis, Matthew J Ellis, Chonghui Cheng
Surface Marker Identification To Capture Live Circulating Tumor Cells In Metastatic Triple-Negative Breast Cancer, Ping Gong, Michael T Lewis, Matthew J Ellis, Chonghui Cheng
Faculty, Staff and Students Publications
Metastatic triple-negative breast cancer (TNBC) is highly aggressive and lacks targeted therapies. Circulating tumor cells (CTC) are invaluable for monitoring metastatic tumor progression and treatment response but are difficult to capture because of their rarity and heterogeneity. Surface-based staining for live CTCs is essential to preserve RNA quality in single cells, but current markers tend to perform poorly on more mesenchymal tumor cells such as TNBCs. To enhance live TNBC CTC detection, we developed a workflow for live CTC capture and single-cell RNA sequencing (scRNA-seq). Using a mouse model of metastatic TNBC, we identified four new CTC surface markers, AHNAK2, …
“They Told Me To Succeed Where They Couldn’T”: Parent Support And Stem Motivation Among Stem Majors From Low Socioeconomic Status Backgrounds, Christine R. Starr, Tess A. Shirefley
“They Told Me To Succeed Where They Couldn’T”: Parent Support And Stem Motivation Among Stem Majors From Low Socioeconomic Status Backgrounds, Christine R. Starr, Tess A. Shirefley
Human Development & Family Science Publications and Presentations
Grounded in situated expectancy-value theory, this retrospective mixed-methods study examined how parent support during adolescence relates to STEM (science, technology, engineering, and math) motivation among low SES undergraduates currently majoring in STEM (n = 222; 86% women; 53% White, 19% Latine, 17% Asian, 7% Black). Past work has demonstrated that parent support positively relates to STEM motivation. However, few studies have examined this pattern amongst low socioeconomic status (SES) students, defined as students who are first-generation and/or from low-income backgrounds. Open-response thematic analysis revealed that socioemotional support, instrumental support, and role models were the most common forms of support for …
The Prehistory Of The Interim Docket, Aditya Bamzai, Samuel L. Bray
The Prehistory Of The Interim Docket, Aditya Bamzai, Samuel L. Bray
Public Law and Legal Theory Working Papers
Did the Supreme Court issue stays of lower court judgments before the modern era? This Essay explores the underappreciated history of the Supreme Court’s issuance of interim relief. As we show, the Supreme Court has relied on a wide variety of statutory and common law authorities to issue stays long before the recent controversies attending the “shadow” or “interim” docket. This history demonstrates that the Court has always had authority to fashion interim relief of some kind. More- over, it supports the conclusion that the Supreme Court’s authority under the All Writs Act exists even when a more specific statutory …
Cheap Violence: Weapons And The Law, Joseph Blocher, Darrell A. H. Miller
Cheap Violence: Weapons And The Law, Joseph Blocher, Darrell A. H. Miller
Public Law and Legal Theory Working Papers
A primary task of law is to control violence. Nearly every imaginable rule-of-law value depends on the success of that endeavor, and some of the most foundational works in legal and political theory begin with an effort to understand the relationship between law and violence. Many of those works were written during periods where the lines between law and violence were blurred, and current threats to the rule of law have sparked renewed interest in the structural interactions between law, violence, and the state.
Missing from this discussion has been a comparably deep analysis of the relationship between law and …
The First Amendment, Federal Employees, And The War On The “Deep State”, Sonja Starr
The First Amendment, Federal Employees, And The War On The “Deep State”, Sonja Starr
Public Law and Legal Theory Working Papers
This essay analyzes, from a First Amendment perspective, the second Trump administration’s efforts to align the federal workforce with its ideological preferences. The administration has broad powers to reshape the executive branch’s policy priorities and its messaging. But as I show with examples across the civil, military, and foreign services, it has gone beyond exercising those powers, retaliating against and restricting employees’ protected private speech and incorporating viewpoint- based conditions into hiring. These actions reflect a constitutional vision that stretches existing limits on public employee rights and, for many employees, subordinates those rights entirely when they conflict with purported Article …
Agglomerama, Lee Anne Fennell
Agglomerama, Lee Anne Fennell
Public Law and Legal Theory Working Papers
No abstract provided.
The Limits Of Text, Farah Peterson
The Limits Of Text, Farah Peterson
Public Law and Legal Theory Working Papers
Let’s say the “laws” are the rules that actually constrain power, organize government, and coerce people. That is, let’s define the law as the system of rules we experience, and not just the system of rules our statutes, precedents, and founding documents describe. Just now, during the second Trump presidency, the gap between the law as it is written and the law as we experience it is obvious even to lay observers. Yet the dominant ways of thinking about law—textualism and originalism—are so focused on the proper interpretation of our legal texts that I fear we have lost sight of …
The New Law Of Viewpoint Discrimination, Genevieve Lakier
The New Law Of Viewpoint Discrimination, Genevieve Lakier
Public Law and Legal Theory Working Papers
The prohibition against viewpoint discrimination is one of the oldest and most important principles of First Amendment law. But what it means to viewpoint discriminate has changed significantly over time. For much of the twentieth century, the principle was interpreted to prohibit the government from restricting speech because of the specific ideas or opinions it communicated. Beginning in the 1990s, however, the Court began to define viewpoint discrimination more broadly, to include state actions that, rather than targeting specific ideas or opinions, discriminate against attitudes and perspectives that are shared by those who otherwise differ profoundly in their beliefs. This …
An Engine, Not A Vessel: Place, Politics, And Health In The United States, Philip B. Rocco
An Engine, Not A Vessel: Place, Politics, And Health In The United States, Philip B. Rocco
Political Science Faculty Research and Publications
Social scientists often treat places as containers for social and economic phenomena that shape health outcomes. Yet this analytic practice conceals more than it reveals. Local governments in the United States should be understood as engines of both health promotion and stratification. As the contributions to this symposium suggest, governments not only occupy a formal place in the U.S. public health system, their decisions on everything from housing to transportation infrastructure can also have profound impacts on health outcomes. Local political economies likewise renegotiate the parameters of acceptable health interventions, public understandings of health disparities, and the status of population …
‘The Limits Of The Landscape: A Critical Examination Of Outdoor Learning, Self-Regulation, And Semh Within Neoliberal Schooling’, Nicola Clayton
‘The Limits Of The Landscape: A Critical Examination Of Outdoor Learning, Self-Regulation, And Semh Within Neoliberal Schooling’, Nicola Clayton
School of Law, Humanities and Social Sciences Theses
This doctoral thesis critically examines a specialised outdoor learning intervention for primary pupils with significant Social, Emotional, and Mental Health (SEMH) needs who are at risk of exclusion. It assesses the intervention’s implementation and its efficacy in supporting these pupils' capacity for self-regulation and stress management.The study is situated amidst escalating global child mental health concerns and recent English educational policy shifts that mandate schools to actively foster pupil well-being. Exploring outdoor education as a widely cited approach for promoting positive mental health, this research engages with established social theories, particularly those of Bernstein and Bourdieu, to critique the wider …
Lessons Of Loss, Life, And Those Left Behind; An Exploration Of The Experience Of Student Suicide Loss Within The Higher Education Learning Community And How To Best Respond To The Suicide Bereft Within Higher Education., Kirsty Benyon-Marno
School of Law, Humanities and Social Sciences Theses
This thesis explores the experiences of those bereaved by student suicide within higher education (HE) learning communities in the United Kingdom. While increasing attention has been given to student mental health and suicide prevention, the experiences of those left behind, both students and staff, remain under-researched, often silenced by stigma, and insufficiently understood in policy and practice. This study seeks to address this gap by centring the voices of the suicide-bereaved and examining how grief is experienced and navigated within HE contexts.The research adopts a praxeological methodological framework, understanding knowledge as emerging through practice, relationships, and reflexive engagement. Data were …
Educational Interventions To Prepare Undergraduate Students For Out-Of-Hours Practice As A Newly Qualified Doctor In The United Kingdom: A Scoping Review, Alex Gordon, Molly Parkinson, Rosanna Watts, Kamal El-Badawi, Erin Dawson, Rohan Chiktara, Lorna Burns, Nicola Brennan
Educational Interventions To Prepare Undergraduate Students For Out-Of-Hours Practice As A Newly Qualified Doctor In The United Kingdom: A Scoping Review, Alex Gordon, Molly Parkinson, Rosanna Watts, Kamal El-Badawi, Erin Dawson, Rohan Chiktara, Lorna Burns, Nicola Brennan
Peninsula Dental School
Background: In the United Kingdom (UK), newly qualified doctors are routinely responsible for out-of-hours (OOH) care, often managing acutely unwell patients with limited supervision. Despite national recommendations encouraging OOH experience during medical school training, there is no formal curriculum for OOH practice. Objectives: This scoping review aimed to identify the range of educational interventions designed to prepare UK medical students for OOH clinical responsibilities and assess their reported effects on perceived and actual preparedness. Methods: Following Joanna Briggs Institute methodology, a systematic search of seven databases and grey literature sources was conducted. Eligible studies involved UK-based medical students and reported …
The Impact Of Users On The Operational Effectiveness Of Residential Photovoltaic Systems In Fragile-Grid Contexts: Iraq As A Case Study, O. Al-Hafith, B. Al-Hafiz, Z. Alhafedh
The Impact Of Users On The Operational Effectiveness Of Residential Photovoltaic Systems In Fragile-Grid Contexts: Iraq As A Case Study, O. Al-Hafith, B. Al-Hafiz, Z. Alhafedh
School of Art, Design and Architecture
Residential photovoltaic (PV) systems are increasingly promoted as key components of low-carbon and intelligent buildings. While extensive research has examined technological and climatic influences on PV performance, limited attention has been given to how users operate PV systems and the operational challenges that arise, particularly in fragile-grid contexts where PV systems function as primary electricity sources. This study addresses this gap by exploring user practices and identifying operational challenges affecting residential PV system performance in Iraq, a high-solar context characterised by persistent electricity supply interruptions. A mixed-methods approach was adopted, combining operational data from 30 PV system loggers with survey …
Degrees Of Separation: Grandchildren's Experiences Of Grandparental Brain Tumor Or Stroke, Emily Sapsford, Alyson Norman, Sue Jackson, Josh Deacon, Emily Ravenhill, Pete Keohane
Degrees Of Separation: Grandchildren's Experiences Of Grandparental Brain Tumor Or Stroke, Emily Sapsford, Alyson Norman, Sue Jackson, Josh Deacon, Emily Ravenhill, Pete Keohane
School of Psychology
The impact of acquired brain injury on family members is far reaching. Research has identified experiences of trauma, ambiguous loss and burden of care. Limited research has addressed the ripple effect of brain injury across the wider family. The study aimed to gain a detailed insight into the lived experiences of grandchildren of those who have experienced stroke or brain tumor. Ten participants (eight female and two males aged between 18 and 29) took part in semi-structured interviews about their experiences of grandparental stroke or brain tumor. Data were analyzed using interpretive phenomenological analysis (IPA). Four themes were identified. The …
Integrating Neuroscience And Social Psychology In Researching Interprofessional Education: The Inspire Framework, Kimberley Schenke, Pamela Rae, Jaysan Charlesford, Phil Gee
Integrating Neuroscience And Social Psychology In Researching Interprofessional Education: The Inspire Framework, Kimberley Schenke, Pamela Rae, Jaysan Charlesford, Phil Gee
School of Psychology
There is an increasing focus on the importance of interprofessional education as an integral part of health and social care training. However, the fundamental psychological processes underlying successful interprofessional education are not well understood. Here we propose a single framework, Integrating Neuroscience and Social Psychology In Researching Interprofessional Education (INSPIRE), grounded in evidence from social psychology and neuroscience that could be used to generate testable hypotheses to inform the design, development and evaluation of interprofessional education. The application of this framework offers a novel, scientifically grounded approach to improving the learning outcomes of interprofessional education and provides a foundation for …
Counterfactual Thinking And Aging: The Role Of Executive Function., Clare Walsh, Catherine Deeprose, Raluca A. Briazu, Alison Bacon
Counterfactual Thinking And Aging: The Role Of Executive Function., Clare Walsh, Catherine Deeprose, Raluca A. Briazu, Alison Bacon
School of Psychology
People frequently think about how events in the past might have happened differently and these thoughts play a central role in their cognitive, emotional and social functioning. Our study examined how these processes change with age. A group of 56 younger (mean age 22.34) and 50 older (mean age 71.96) adults completed tasks measuring the spontaneous generation of counterfactual thoughts, the generation of counterfactual thoughts when cued and the Counterfactual Inference Test which taps into the ease with which salient counterfactual thoughts come to mind. They also completed a Counterfactual Seeking Task to measure their motivation to seek out counterfactual …
When Are Foot Pursuits Really Necessary?: How Improved Policies Might Reduce Community Harm, Sharon R. Fairley
When Are Foot Pursuits Really Necessary?: How Improved Policies Might Reduce Community Harm, Sharon R. Fairley
Public Law and Legal Theory Working Papers
Despite the widely accepted view that foot pursuits are inherently dangerous for both police officers and citizens, a minority of municipal police agencies have adopted policies that have the potential to minimize the risk of harm by limiting the circumstances in which police officers are permitted to pursue a subject on foot. This paper presents data related to foot pursuit incidents and existing foot pursuit policies. The paper documents that most existing foot pursuit policies are limited in their potential to reduce unwarranted deadly encounters because the guidance they provide requires officers to consider and weigh vague concepts in tense, …
Administrative Self-Constitutionalism, Brian Lipshutz
Administrative Self-Constitutionalism, Brian Lipshutz
Public Law and Legal Theory Working Papers
Since the days of the Interstate Commerce Commission, federal agencies have generally refused to address the constitutionality of statutory provisions. They have offered little reasoning to justify that refusal, yet scholars have generally accepted it. This Article explains why agencies can—and should—address constitutional challenges to statutory provisions.
Agencies have the power to assess the constitutionality of statutory provisions. They already exercise a similar authority when they apply the canon of constitutional avoidance and consider the constitutionality of individual actions. There is no basis for stopping short of addressing challenges to statutes. And many scholars have recognized that, as a formal …
The Protective Power Of Psychological Resources In Mitigating Burnout And Enhancing Flourishing, Dylan R. Polkinghorne, David J. Radosevich, Deirdre M. Radosevich, Dianne D. Murphy, Laken James, Sue S. Craver
The Protective Power Of Psychological Resources In Mitigating Burnout And Enhancing Flourishing, Dylan R. Polkinghorne, David J. Radosevich, Deirdre M. Radosevich, Dianne D. Murphy, Laken James, Sue S. Craver
Management Faculty Research and Publications
Purpose
This study explores how burnout mediates the relationships between critical psychological resources, specifically resilience, flow and self-efficacy, and flourishing in contemporary work environments.
Design/methodology/approach
Data from 374 participants, including undergraduate students at a regional comprehensive university in the Midwest and full-time working adults in the USA, were analyzed using mediation analysis in MPlus 8.11 to assess the indirect and direct effects among burnout, psychological resources and flourishing in a work environment.
Findings
Results indicate that self-efficacy significantly predicts lower burnout levels and higher flourishing. Resilience and flow were negatively associated with burnout, reducing its impact; however, the direct effects …
Schelling & Spinoza, Michael Vater
Schelling & Spinoza, Michael Vater
Philosophy Faculty Research and Publications
Schelling is notorious for having a fluid vision of systematic philosophy and its methods. In an age where philosophy is expected to result in one or two books, not years of discussions with students and colleagues--and certainly not a distillation of one’s way of life--Schelling’s thought has been called protean or restless, or in Hegel’s snarky verdict “an education pursued in public.” The same could be said of Socrates. But there is a truth in these comments; it is difficult to find in fifty-six years of publications, addresses and abandoned manuscripts the single argument that is Schelling’s philosophy. What provokes …
An Educational Intervention On Mutual Goal Setting For Hospital Nurses: A Mixed-Methods Study, Teresa Jerofke-Owen, Kristi Opper, Joseph Beiler, Maharaj Singh
An Educational Intervention On Mutual Goal Setting For Hospital Nurses: A Mixed-Methods Study, Teresa Jerofke-Owen, Kristi Opper, Joseph Beiler, Maharaj Singh
College of Nursing Faculty Research and Publications
Background:
Including patients in mutual goal setting is one mechanism to personalize care delivery and improve patient outcomes.
Objective:
The purpose of this study was to examine the impact of a nurse educational intervention about mutual goal setting on nurse engagement and self-efficacy for goal setting and the nurse/patient experience of goal setting.
Methods:
During this explanatory, sequential mixed-methods study, nurse engagement in goal setting and goal quality was assessed through chart audits 1-month pre-intervention (n = 173) and 1 and 3-months (n = 144, n = 137) post-intervention. Nurse self-efficacy was measured with the Appraisal Inventory Tool. Patient experience …
Artificial Intelligence And Mental Health: Promise, Pitfalls And Ethical Priorities, Maharaj Singh
Artificial Intelligence And Mental Health: Promise, Pitfalls And Ethical Priorities, Maharaj Singh
College of Nursing Faculty Research and Publications
Mental health conditions are prevalent across the lifespan, yet workforce shortages, long waiting times, and fragmented systems mean many people never receive timely, evidence‑based care. Artificial intelligence (AI), including machine‑learning classifiers and large language models (LLMs), is being explored to support earlier detection, closer symptom monitoring and scalable psychoeducation. Early studies suggest AI can surface risk signals from language, sleep/activity traces and clinical notes; summarise complex records for clinicians; and deliver structured self‑help at scale. At the same time, safety, bias, privacy and accountability concerns remain salient.
Browser-Based Phishing Detection System Using Modern Web Technologies, Muhammad Arshad, Beena Sherin Kuriakose, Choo Wou Onn, Farhan Ahmad Siddiqui, Mohammad Shahid Kamal
Browser-Based Phishing Detection System Using Modern Web Technologies, Muhammad Arshad, Beena Sherin Kuriakose, Choo Wou Onn, Farhan Ahmad Siddiqui, Mohammad Shahid Kamal
Research Outputs: 2025-Present
Phishing remains one of the most persistent cybersecurity threats, exploiting human trust to steal sensitive information through deceptive websites. Traditional detection methods, reliant on blacklists and reactive reporting, offer limited protection against rapidly evolving zero-day attacks. To address these challenges, this study proposes and evaluates a hybrid browser-resident phishing detection framework that combines three complementary detection mechanisms: a locally executed Random Forest model using URL lexical features, lightweight real-time DOM structure analysis, and VirusTotal’s multi-engine reputation service. Communication between the client and server is optimised using gRPC over the QUIC protocol, ensuring secure, high-performance data exchange with built-in retry mechanisms …