Digital Commons Network^™

Primary Avian Tracheal Cell Models For The Isolation Of Emerging Avian Metapneumovirus Strains, Tricia Serrao

Electronic Theses and Dissertations

The emergence of avian metapneumovirus (aMPV) subgroups A and B in the United States poultry industry has created an urgent need for standardized, host-specific diagnostic platforms. Historically, reliance on continuous, multi-species cell lines has limited the primary isolation of field strains and introduced potential adaptation artifacts. To address these challenges, this research first established and characterized a reproducible primary cell culture system derived from the tracheal tissues of 1-day-old turkey poults. This system was maintained in an optimized DMEM/F-12 formulation supplemented with 5% FBS, EGF, and ITS, with early-passage cultures achieving 90% confluence within 24 to 48 hours. Morphological and …

The Influence Of Controlled Intake And Anabolic Implant Timing On Growth Performance And Carcass Traits In Feedlot Ruminants, Justin J. Delver

Electronic Theses and Dissertations

The objective of this dissertation was to evaluate how previous plane of nutrition and anabolic implant timing interact to influence growth performance, composition of growth, and the carcass characteristics in ruminants. Three experiments were conducted using cattle and sheep models to determine the metabolic adaptations driving compensatory growth. In experiment 1, yearling beef steers (n = 192) were fed ad libitum for 141 days (ADLIB) or restricted to 92% of ad libitum intake for 56 (RES56) or 86 (RES86) days followed by realimentation. Cumulative dry matter intake (DMI) was reduced in both restricted groups (P = 0.002) with no difference …

Effect Of Increasing Potency Of Steroidal Implants In Beef Steers At Weaning From Dry-Lot To Finish, Weston Joseph Peschel

Electronic Theses and Dissertations

The receiving phase is a stressful transition period in beef production. Newly weaned cattle are offered low-energy, high-forage diets promoting lean tissue and bone development prior to the finishing phase. Steroidal implants containing trenbolone acetate (TBA) and estradiol benzoate (EB) enhance lean gain. Aggressive early implant exposure has been shown to negatively impact intramuscular fat deposition. This two-part study evaluated the initial and carryover effects of increasing doses of combined TBA and EB weaning implants on growth performance, serum metabolites, and carcass traits. In Exp. 1, newly weaned Charolais × Red Angus crossbred beef steers [n = 240 initially; body …

Modeling Heterogeneous Trajectories Of Chronic Kidney Disease Progression With Finite Mixture Models Using The All Of Us Dataset, Yahaya Mumuni Musah

Electronic Theses and Dissertations

Background: Chronic kidney disease (CKD) does not progress uniformly across patients, and a single average trajectory often fails to capture this heterogeneity. Understanding variation in disease progression is important for improving risk stratification and clinical management. 
Objectives: This study aims to characterize the heterogeneity of chronic kidney disease (CKD) progression using longitudinal estimated glomerular filtration rate (eGFR) data and to identify factors associated with distinct progression trajectory patterns. 
Methods: A longitudinal cohort study was conducted using data from the All of Us} Research Program collected between April 23, 2002, and October 1, 2023. Adult participants with repeated eGFR measurements were …

Hypothyroidism Is Associated With Higher Healthcare Utilisation And Higher Need For Blood Transfusion After Primary Total Knee Arthroplasty (Tka) In Patients With Osteoarthritis: A National Inpatient Sample Analysis

Faculty, Staff and Students Publications

Purpose: To examine the association of hypothyroidism with primary total knee arthroplasty (TKA) outcomes in adults with primary underlying diagnosis of osteoarthritis (OA).

Methods: We identified a prospective cohort of patients in the 2016-2020 national inpatient sample (NIS) that received primary TKA with an underlying diagnosis of OA, identified using International Classification of Diseases, Tenth Revision, Common Modification (ICD-10-CM) and Procedure Coding System (ICD-10-PCS) codes in the primary procedure and diagnosis positions, respectively. We performed multivariable-adjusted regression analyses for healthcare utilisation (length of hospital stay, hospital charges and discharge destination) and clinical outcomes (blood transfusion; prosthetic fracture, dislocation or infection; …

Case Report: Primed Dendritic Cell Immunotherapy For Multiple Solid Tumors, Luis Ferbeyre, Gregorio Viramontes, Rafael Gonzalez, Elideth Angulo, Antonio Zamudio, Raul Hernandez, Stephen Noga, Susana Hernandez-Reyes, Paul Zhang, Darryl Smith, Ara Karamanian, Luis Tamara, Dalton Greenwood, Matthew Halpert

Faculty, Staff and Students Publications

Many patients with advanced solid tumors ultimately develop resistance to conventional therapies, with especially limited options for those experiencing rapid progression or poor performance status, highlighting the need for personalized immunotherapies capable of inducing durable responses. In this retrospective case series, we describe the clinical course and outcomes of five adults (4 male, 1 female; median age 51 years [range, 39-62]) with metastatic solid tumors who achieved complete and durable remission following doubly loaded autologous dendritic cell therapy after failure of standard treatments, such as immune checkpoint inhibition, radiation, surgery, or endocrine therapy. Five patients, including prostate adenocarcinoma (n=1), malignant …

A Review Of Current Research And Barriers To Access: Exploring Disparities In Pediatric Epilepsy Surgery, Meena Vessell

Faculty, Staff and Students Publications

Background: Drug-resistant epilepsy (DRE) impacts at least 30% of pediatric epilepsy patients, adversely affecting neurodevelopment and quality of life, as well as risk of sudden unexplained death in epilepsy (SUDEP). While surgical intervention has proven to be an effective treatment for DRE, disparities in access to surgical care persist. Compared to adults, pediatric patients face unique challenges, including delayed recognition of surgical candidacy, limited access to specialized epilepsy centers, complex care coordination, and socioeconomic barriers.

Summary: This review explores the current state of pediatric epilepsy surgery, highlighting its effectiveness in achieving seizure freedom, improving neurocognitive outcomes, and reducing long-term healthcare …

Personalizing Therapies Over The Course Of Hormone Receptor-Positive/Her2-Negative Metastatic Breast Cancer, Suzanne A Fuqua, Rachel M Layman, Debu Tripathy

Faculty, Staff and Students Publications

The hormone receptor (HR)‐positive/human epidermal growth factor receptor 2 (HER2)‐negative breast cancer subtype accounts for most early and metastatic breast cancer (MBC) cases. HR‐positive/HER2‐negative MBC is characterized by a relatively prolonged, although variable, disease course and substantial intertumoral and intratumoral heterogeneity. Although endocrine‐based therapies remain the cornerstone of treatment, nearly all patients eventually develop resistance, which is increasingly addressed with biologically targeted agents and newer‐generation cytotoxic drugs. This review summarizes the current understanding of HR‐positive/HER2‐negative MBC biology, highlighting mechanisms of intrinsic and acquired resistance, including driver genomic alterations that, along with clinical factors, help guide therapeutic choices and sequencing. The …

Sodium Supplementation Algorithm To Promote Growth In Infants Who Are Preterm: Randomized Clinical Trial, Kelly Mosesso, Valerie Hole, William W Wong, Shaji K Chacko, Jeffrey L Segar

Faculty, Staff and Students Publications

Objective: Evaluate the effectiveness of an algorithm using urine sodium (Na) concentration to guide dietary Na supplementation compared with standard care to promote growth in infants who are preterm.

Methods: A randomized trial was conducted in 4 neonatal units in Indianapolis, Indiana, involving infants between 250/7 to 296/7 weeks gestation with birthweight > 500 g. Study arms consisted of standard care or use of algorithm beginning at 14 to 17 days postnatal age. The primary outcomes were somatic growth (weight, length, and head circumference) measured by change in Z-score between aged 2 weeks and 36 weeks postmenstrual age (PMA). Secondary outcomes …

Efficacy And Safety Of Pyrimidine Nucleos(T)Ide Therapy In Thymidine Kinase 2 Deficiency, Carmen Paradas, Fernando Scaglia, Irene Rebollo Mesa, Carl Chiang, Anny-Odile Colson, Susan Vanmeter, Cristina Domínguez-González

Faculty, Staff and Students Publications

Thymidine kinase 2 deficiency (TK2d) (MIM 609560) is an ultra-rare, autosomal recessive mitochondrial myopathy caused by TK2 variants, leading to mitochondrial DNA depletion and/or multiple deletions. People with thymidine kinase 2 deficiency experience progressive myopathy, bulbar weakness and respiratory insufficiency, often losing the ability to walk, eat and breathe independently. Doxecitine and doxribtimine represents the first approved treatment for patients with thymidine kinase 2 deficiency with age of symptom onset ≤12 years by the US Food and Drug Administration and the European Medicines Agency; previously, disease management was limited to supportive care. We investigated the efficacy and safety of pyrimidine …

The All Of Us Evenings With Genetics Research Program, Julie Coleman, Laterrica Williams, April Adams, Ashley Butler, Elizabeth Atkinson, Shamika Ketkar, Steven Scherer, Kim Worley, Susan Fernbach, Keasia Daniels, Latanya Hammonds-Odie, Laura Rosales, Brendan Lee, Debra Murray

Faculty, Staff and Students Publications

The All of Us Evenings with Genetics (All of Us EwG) Research Program, funded in part by the National Institute of Health’s All of Us Research Program, engages researchers to utilize the All of Us Researcher Workbench to advance precision medicine. The All of Us EwG program has two core aims: (1) address barriers to research productivity for minorities, disadvantaged, and persons with disabilities aspiring to enter STEM fields; and (2) promote the use of the All of Us Researcher Workbench to develop research focused on health equity. To achieve these goals, the program implements three key activities: (1) …

Mindful Diagnostics In Culture-Negative Endocarditis: Early Noninvasive Diagnosis Of Tropheryma Whipplei By Plasma Microbial Cell-Free Dna, Laura C Lelenwa, Enrique Garcia-Sayan, Kenneth K Liao, Ahmed Hamdi, Todd Lasco, Mayar Al Mohajer

Faculty, Staff and Students Publications

Tropheryma whipplei was identified by plasma microbial cell-free DNA sequencing within 4 days in severe culture-negative endocarditis after antibiotics had already been started. The result supported earlier diagnostic clarification and antimicrobial de-escalation before valve pathology was available, illustrating a practical diagnostic-stewardship role for noninvasive sequencing in high-acuity endocarditis.

Survodutide For Treatment Of Obesity: Baseline Characteristics Of Participants In A Randomized, Double-Blind, Placebo-Controlled, Phase 3 Trial (Synchronize™-1), Elke Platz, Gabriele Bleckert, Samina Ajaz Hussain, Martina Brueckmann, Elena Startseva, Isabel M Kloer, Lee M Kaplan

Faculty, Staff and Students Publications

Aims: Survodutide, a novel glucagon receptor and glucagon-like peptide-1 (GLP-1) receptor dual agonist, elicited significant weight loss in a phase 2 trial in individuals with obesity without type 2 diabetes (T2D). Two multinational phase 3 trials are investigating survodutide for obesity management in individuals with or without T2D. We report the baseline characteristics of participants in the SYNCHRONIZE-1 trial in adults with obesity without T2D (ClinicalTrials.gov: NCT06066515).

Materials and methods: Participants aged ≥18 years with BMI ≥30 or ≥27 kg/m2 with ≥1 obesity complication without T2D were randomized 1:1:1 to double-blind, once-weekly, subcutaneous injections of survodutide (up-titrated to 3.6 …

The Lived Experience Of Pediatric Pain Management: Insights From Families And Providers, Paul Checchia, Katherine Shwetz, Natasha Afonso

Faculty, Staff and Students Publications

Pain represents a subjective experience that manifests with emotional and physical discomfort. In pediatric care, pain management is especially complex due to communicative limitations, which creates a unique point of entry for parents to contribute to their child's treatment process. In this study, we explored whether families' perceptions of their child's pain and preferences for treatment were aligned with healthcare providers' pain management decisions. Using narrative-informed techniques in interviews with families and healthcare providers in pediatric care settings, we analyzed areas of concordance and discordance in pain assessment and treatment priorities. Our findings show that trust is built over time …

A Year In Review On Tuberculosis And Non-Tuberculous Mycobacteria Disease: A 2026 Update For Clinicians And Scientists, Yousra Kherabi, Liga Kuksa, Berit Lange, Christoph Lange, Natalie Lorent, Francesca Saluzzo, Martina Sester, Xenia Emilie Sinding Iversen, Marc Tebruegge, Conor Tweed, Anca Vasiliu, Lorenzo Guglielmetti, Tuberculosis Network European Trials Group (Tbnet)

Faculty, Staff and Students Publications

Background: Tuberculosis (TB) remains a major cause of morbidity and mortality worldwide, while infections from non-tuberculous mycobacteria (NTM) represent a growing public health threat. In its 20th year of activity, the Tuberculosis Network European Trials group (TBnet; www.tbnet.eu) is one of the leading research networks in Europe. In this review, we summarize the main advances in TB and NTM that occurred in 2025.

Methods: We conducted a non-systematic review of articles published in 2025, with a strong emphasis on research with current or potential impact on clinical practice. We also selected the most impactful papers regarding the management of adult …

Developing A Best Practice Guideline For Clinical Practice In A Digital Health Environment: Systematic Reviews Based On The Grading Of Recommendations, Assessment, Development, And Evaluation Approach, Lauren Bailey, Lyndsay Howitt, Nafsin Nizum, Christine Buchanan, Maureen Charlebois, Jennifer Yoon, Rob Beleno, Michelle Beyn, Rebecca Bliss, Elizabeth Borycki, Margarita Cleghorne, Sandra Davidson, Lorie Donelle Phd, Rn, Fcan, Faan, Alexander Hamilton, Tsz Yee Ip, Margery Konan, Daile Moffat, Sanaz Riahi, Tiziana Rivera, Tammy Rooke, Vaishali Sengar, Steve Sottile, Meredith Whitehead, Vanessa Burkoski

Publications

Background:

Digital health refers to the field of knowledge and practice associated with the development and use of digital technologies to improve clinical practice and health outcomes. Knowledge of digital health technology is becoming essential for all nurses and health providers.

Objective:

This study aims to present the results of the systematic reviews that were used to inform the recommendations in a best practice guideline (BPG) following the GRADE (Grading of Recommendations, Assessment, Development, and Evaluation) approach. Reviews focused on digital health education for nurses and health providers, peer champion models, and the use of predictive analytics in digital health …

Digital Truth Making, Creative Resistance, And Power Negotiation Through Social Media: A Digital Ethnography Of The 2024 Gen Z Uprising In Bangladesh, Mustafizurrrahman Rahat

Theses and Dissertations

This research investigates how social media shaped political participation during the 2024 July Uprising in Bangladesh, focusing on the production and negotiation of political truth, legitimacy, and resistance through everyday digital practices. Rather than conceptualizing social media solely as a communication tool, the study analyzes digital platforms as contested spaces where activists, state-aligned actors, and other participants constructed, circulated, and challenged competing political narratives throughout the uprising.

Drawing on digital ethnography, this study integrates netnographic observation of Facebook groups, pages, hashtags, memes, and protest-related visual content with content analysis, reflexive participant observation, and semi-structured interviews with Generation Z participants. The …

Cultivating Culturally Responsive Special Educators: A Qualitative Study Of Self-Efficacy Journeys Across Preservice Preparation And Inservice Professional Development, Ashley R. Norton

Theses and Dissertations

In an increasingly diverse society, educators must be prepared to effectively instruct students from a wide range of cultural, linguistic, and ability backgrounds. Teacher self-efficacy in culturally responsive practices (CRP) is critical to achieving equitable educational outcomes, particularly in special education, where students often experience multiple forms of marginalization. Despite the importance of culturally responsive teaching, limited research has examined how special educators develop culturally responsive teaching self-efficacy (CRTSE) over the course of their professional careers, particularly in urban school districts serving culturally and linguistically diverse (CLD) populations.

This qualitative study explored the self-efficacy journeys of special educators and their …

Between Stigma And Strength: How Ghanaian Mothers Navigate Societal Judgement And Build Resilience While Raising Children With Disabilities., Vera Bonku Turkson

Theses and Dissertations

The study explores the lived experiences of mothers raising children with disabilities in Ghana, West Africa. The purpose of the study is to understand mothers’ everyday caregiving realities, their experiences with social stigma, and the ways they build resilience. A semi-structured interview was conducted where a total of eleven Ghanaian mothers/caregivers were interviewed through phone calls, WhatsApp calls, and Zoom. The data were then analyzed using Braun and Clarke’s (2006) thematic analysis guide, which resulted in the development of five themes. The findings reveal that mothers’ experiences are shaped by continuous caregiving demands, financial strain, and deeply embedded cultural beliefs …

Abject And Uncanny Manifestations Of Sexuality And Sexual Desire In Nineteenth-Century Gothic Literature, Varvara Kuznetsova

Theses and Dissertations

This thesis explores the ways in which psychoanalytic concepts of the abjection and the uncanny were used to depict monsters and monstrous bodies in nineteenth-century Gothic literature as a site of social, cultural, and sexual transgression. Through the intersections of queer theory, monster theory, and psychoanalytic theory, I examine and analyze depictions of women as monstrous figures in Samuel Taylor Coleridge’s Christabel (1816), Mary Shelley’s Frankenstein; or, The Modern Prometheus (1818), and Sheridan Joseph Le Fanu’s Carmilla (1872). In particular, I aim to detail how language and descriptions of women monsters become coded elements that reveal monstrosity and transgression.

Examining Explicit Professional Development As A Means To Change Inclusive Mindsets, Mitchell E. Elatkin

Theses and Dissertations

Inclusive education requires educators to hold beliefs that support the participation and success of students with disabilities in general education settings. Although federal policy mandates access to the least restrictive environment, educator attitudes toward inclusion continue to influence the implementation of inclusive practices. The purpose of this mixed-methods study was to examine whether explicit professional development (PD) focused on inclusive mindsets influenced school stakeholders’ attitudes toward inclusion across a school year. Participants included representatives from various roles within a charter school organization in the Midwest. The researcher collected data through two administrations of the Adapted Teacher Attitudes Toward Inclusion Survey …

Refusing To Die On The Vine: Black Women's Survival, Resistance, And Dei Labor In Historically White Institutions, Senesta D. Howard

Theses and Dissertations

This dissertation examines the lived experiences of Black women in non-diversity, non-faculty roles at historically White institutions (HWIs) who engage in diversity, equity, and inclusion (DEI) advocacy beyond their formal job responsibilities. Grounded in Black Feminist Thought and guided by Interpretative Phenomenological Analysis, the study explores how race and gender shape invisible labor expectations, emotional and psychological burdens, and strategies for safety and meaning-making. Semi-structured interviews with 12 Black women staff members yielded seven interrelated themes, including invisible DEI labor, hypervisibility, emotional exhaustion, sisterhood as a form of resistance, respectability politics, self-constructed safety, and purpose rooted in legacy and spirituality. …

Institutional Retention And Graduation Outcomes Before And During Covid-19: A Comparison Of Online-Experienced And Online-Inexperienced Four-Year Institutions, Nicholas J. Finnessey

Theses and Dissertations

This study examined whether student success outcomes and their trajectories over time differed across higher education institutions before, during, and after the COVID-19 pandemic based on prior experience with online education. Guided by Astin’s (1993) Input-Environment-Output (I-E-O) framework, pre-pandemic participation in online coursework was conceptualized as an institutional-level environmental condition. A quantitative, causal-comparative research design was employed, using secondary data from the Integrated Postsecondary Education Data System (IPEDS), to examine longitudinal differences in institutional retention and graduation rates across institutions classified by their pre-pandemic participation in online education. The sample included 528 Title IV-eligible, degree-granting, four-year institutions observed across five …

The Role Of Non-Academic Staff In First-Year Retention At Regional, Comprehensive Universities, Marco A. Krcatovich Ii

Theses and Dissertations

Regional comprehensive universities (RCUs) serve a large share of U.S. undergraduates, yet the role of non‑academic staff in shaping first‑year retention remains understudied. This dissertation examines how staff diversity and staffing structures relate to student persistence using seven years of IPEDS panel data and Linear Mixed‑Effects Models. Analyses were conducted separately for residential and commuter RCUs to reflect their distinct engagement environments. Findings show that staff diversity is significantly associated with retention, though the direction and magnitude vary by campus type and staff role. Staffing structure also matters as higher proportions of full‑time staff are positively associated with retention at …

Parental Behavior, Attachment, And Sibling Outcomes In Asd Families, Bridget W. Mwaura

Theses and Dissertations

Neurotypical siblings of individuals with Autism Spectrum Disorder (ASD) often experience unique challenges, including increased familial stress and differences in parental treatment, which may affect the sibling bond. Grounded in the Attachment Theory and Siblings Embedded Systems Framework, this study examined relationships among attachment security, parenting behaviors and sibling relationship quality. It was hypothesized that secure parental attachment and helpful parenting behaviors would predict greater sibling closeness and lower conflict, and that attachment security would mediate the relationship between parenting behaviors and sibling relationship quality. Results from a sample of emerging adults (N=91) partially supported these hypotheses. Bivariate …

Thinking Machines: Cybernetics, Artificial Intelligence, And Technological Anxiety In The American Cold War, Erin Mae Wilcox

Theses and Dissertations

Following the Second World War, cybernetics emerged as a cross-disciplinary study in philosophy, neurophysiology, electrical engineering, and mathematics. Cyberneticists proposed the formal study of the man-machine analogy; that is, to equate biological structures to a complex mechanical system. Drawing from this analogy, cyberneticists used programmable digital computers to emulate the functions of the human brain. The study of artificial intelligence emerged within this cybernetic discourse in the early 1950s; yet, by the mid-1960s, the two disciplines suffered a methodological fracture. Drawing from a tradition generated by this fracture, historians have traditionally examined cybernetics and artificial intelligence in isolation from one …

Secret-Keeping Experiences Of Young Adults, Jace C. Griffith

Theses and Dissertations

In 2020, researchers Frijns et al. called for a new wave of secret-keeping research which prioritized the person-centric experience of youth keeping secrets. This study added to that collection by comparing two kinds of secret-keeping which are not compared in existing research: secrets which are related to abuse, and secrets which are not. Researchers in the field of child welfare study only abuse-related secret-keeping, almost always qualitatively. Alternatively, researchers of non-abuse secret-keeping or general secret-keeping collect almost entirely quantitative data, absent of the personal experience of secret-keeping.

Through an online survey, 205 undergraduate students were asked to reflect on an …

Leading The Temporary Workforce: Leadership Communication And Adaptation Among Seasonal Employees, Alfred Kwabena Obiri

Theses and Dissertations

Seasonal employees constitute an essential yet understudied workforce sustaining organizational operations during peak demand periods across industries. Despite the growing organizational reliance on temporary employees, organizational communication studies have primary focused on permanent employees with extended socialization periods, leaving important questions about how leadership communication operates in compressed timeframes inadequately addressed. This qualitative study examined how leadership communication practices shape seasonal employees’ adaptation, belonging, and morale within the temporal constraints characteristic of temporary employment. Drawing on organizational socialization theory, leader-member exchange theory and cultural dimensions, this study employed semi-structured interviews with 19 seasonal employees across hospitality, camp, retail, and education …

Social Media, Masculine Body Ideals, And The Drive For Muscularity: A Serial Mediation Model Across Sexual Identities, Sean P. Mcdaniel

Theses and Dissertations

Body image concerns among men are increasingly prevalent yet remain understudied compared to women’s experiences. Drawing on objectification theory, the present study examines the relationship between social media influence and men’s drive for muscularity through a serial mediation model. Specifically, the present study investigates whether the internalization of masculine body ideals and engagement in body surveillance behaviors mediate the link between social media influence and the drive for muscularity. Furthermore, the present study model attempts to explore how these processes differ across sexual identities, given evidence that sexual minority men face distinct sociocultural pressures regarding appearance. Adult male-identifying social media …

Turnover Talk: Organizational Turnover Communication And Its Effects On Turnover Intention, Organizational Identification, And Job Satisfaction, Ethan L. Carroll

Theses and Dissertations

Employee turnover intention has been a focus of organizational research within the field of communication. Communication can affect organizational culture, relational dynamics, and even information flow throughout organizations, which all have influence over employee decisions. The body of literature that pertains to turnover is vast; however, the gap that this study aimed to fill was looking at communication about turnover. The purpose of this study was to investigate and explore communication related to turnover within organizational practices and interactions. This study used a mixed methods approach that first explored the concept of turnover talk and, second, investigated the impact of …