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2026

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An Evidence Review Of Technology Enabled Social Care In The Uk: Report For Cornwall Health Determinants Research Collaboration, Sheena Asthana, Michael Loizou, Marius Varga, Oliver Beer, Rory Baxter, Kieran Green Jan 2026

An Evidence Review Of Technology Enabled Social Care In The Uk: Report For Cornwall Health Determinants Research Collaboration, Sheena Asthana, Michael Loizou, Marius Varga, Oliver Beer, Rory Baxter, Kieran Green

School of Nursing and Midwifery

The Urgent Need for a Shift from Crisis Intervention to Prevention. As highlighted by the Chief Medical Officer, demographic ageing—particularly acute in coastal areas like Cornwall—necessitates a fundamental shift in care models to allow individuals to live as independently as possible. Currently, the potential of digital technologies to support this aim is not being realised. To maintain wellbeing and reduce demand on statutory services, the system must pivot from reactive crisis management to a greater focus on prevention. While technology can play a pivotal role, it will only succeed if integrated into interoperable, data-driven systems that facilitate early intervention and …

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How Does Pre-Registration Child Specific Education Prepare Newly Qualified Nurses’ To Care For Children, Young People, And Their Families? An Empty Narrative Review, Matt Carey, Danielle Edge, Julie Blamires, Mandie Foster, Sarah Neill Jan 2026

How Does Pre-Registration Child Specific Education Prepare Newly Qualified Nurses’ To Care For Children, Young People, And Their Families? An Empty Narrative Review, Matt Carey, Danielle Edge, Julie Blamires, Mandie Foster, Sarah Neill

School of Nursing and Midwifery

This narrative review investigates the influence of child-specific content within pre-registration nursing programs on newly qualified nurses’ perceptions of preparedness to care for children, young people, and their families. Despite international recognition of the specialised competencies required for pediatric nursing, the proportion and quality of child-focused education across Higher Education Institutions is not clear. The Population, Exposure, Outcome framework provided a comprehensive search strategy applied across eight databases to identify relevant studies that met the inclusion and exclusion criteria. Of 663 records identified, 451 were screened and 25 full texts wereassessed for eligibility by two reviewers. No studies met the …

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Exploring The Views Of Children With Cerebral Palsy, Their Parents And Physiotherapists On Participating In A Feasibility Randomised Controlled Trial Testing An Exergaming Device: A Qualitative Study, Rachel Rapson, Jos M. Latour, Jonathan Marsden, Bernie Carter Jan 2026

Exploring The Views Of Children With Cerebral Palsy, Their Parents And Physiotherapists On Participating In A Feasibility Randomised Controlled Trial Testing An Exergaming Device: A Qualitative Study, Rachel Rapson, Jos M. Latour, Jonathan Marsden, Bernie Carter

School of Nursing and Midwifery

Background: This study aimed to understand the experiences and views of children with cerebral palsy, their parents and physiotherapists participating in the ACCEPT feasibility randomised controlled trial, which explored a 10-week physiotherapy intervention using an interactive gaming training device. Design: Qualitative methods included semi-structured interviews, e-diary and photographs. Nine parent–child dyads and three physiotherapists participated. Children were aged between 7 and 16 years; four had co-existing additional needs. Interviews were transcribed. Reflexive thematic analysis was used. Results: Five themes covered the breadth of participants’ experiences: (1) Fitting in therapy; (2) Motivation; (3) New opportunities; (4) Physiotherapists out of their comfort …

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Understanding The Support And Information Needs Of Family Members After Acquired Brain Injury: A Systematic Review, Craig Andrews, Alyson Norman, Sue Jackson, Mark Holloway Jan 2026

Understanding The Support And Information Needs Of Family Members After Acquired Brain Injury: A Systematic Review, Craig Andrews, Alyson Norman, Sue Jackson, Mark Holloway

School of Psychology

The aim of this systematic review was to (a) identify the specific information and support needs of family members caring for ABI survivors and (b) assess the effectiveness of current support systems and resources available. A comprehensive search of the literature was carried out, focusing on studies that were published between the years 2000 and 2025. Seventeen studies met the inclusion criteria. The review employed a narrative synthesis approach to collate findings across papers. The analysis identified five key themes: ABI Knowledge, The Strain of Unsupported Transitions, Emotional and Financial Cost, ABI Support Groups, and Supporting Social Connectedness. The findings …

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Self-Guided Functional Imagery Training To Reduce Anxiety, Jackie Andrade, Stephanie Hartgen-Walker, Caroline Morgan, Ayan, Idil Aytekin, Khadijah Sekoni, Kardelen Sengul, Jonathan Rhodes Jan 2026

Self-Guided Functional Imagery Training To Reduce Anxiety, Jackie Andrade, Stephanie Hartgen-Walker, Caroline Morgan, Ayan, Idil Aytekin, Khadijah Sekoni, Kardelen Sengul, Jonathan Rhodes

School of Psychology

Objectives: Many university students experience high anxiety but have limited access to effective interventions. We evaluated a novel digital intervention for anxiety based on functional imagery training (FIT), designed to help individuals identify the impacts of anxiety, set engagement goals, and strengthen motivation for change. Functional Imagery for Keeping Anxiety low (FIKA) uses speak-aloud tasks, journalling, empathic questions, and personalised guided imagery for a person-centred approach. It builds motivation for engagement goals over safety goals through development and practice of vivid and emotionally laden multisensory imagery. Design: Study 1 used semi-structured interviews and thematic analysis to explore user experiences of …

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Training Healthcare Professionals To Deliver A Group-Based Intervention For People Living With Severe Obesity: Lessons From The Progroup Feasibility Trial, Shokraneh Moghadam, Mark Tarrant, Lily Hawkins, Dawn Swancutt, Rod Sheaff, Laura Hollands, Raff Calitri, Jonathan Pinkney, Jenny Lloyd Jan 2026

Training Healthcare Professionals To Deliver A Group-Based Intervention For People Living With Severe Obesity: Lessons From The Progroup Feasibility Trial, Shokraneh Moghadam, Mark Tarrant, Lily Hawkins, Dawn Swancutt, Rod Sheaff, Laura Hollands, Raff Calitri, Jonathan Pinkney, Jenny Lloyd

School of Psychology

Introduction: Group-based programmes are increasingly adopted to support people living with obesity, as they have the potential to reduce staff time and costs and enhance motivation and capability for behaviour change. Group-based programmes could also provide members with opportunities to form meaningful social connections. As such, training should equip healthcare professionals to deliver group interventions successfully and be accessible and feasible for them to complete. This study presents how mixed-methods process evaluation data from the feasibility randomised controlled trial of PROGROUP (a group-based weight management intervention for people living with severe obesity) informed optimisation of the PROGROUP training programme. Methods: …

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Children And Adults Across 15 Countries Believe In Human Uniqueness Of Mind: A Cross-Cultural Investigation Of Cross-Species Mind Perception, Karri Neldner, Luke Maurits, Magie Junker, Lara Abbas, Nayrouz Abbas, Arianna Abis, Federica Amici, Bernardo Arroyo-Garcia, Negar Asghari, Giovanna Barragán Pardo, Zhen Zhang, Junior Peña Chumacero, Ardain Dzabatou, Dustin Eirdosh, Susan Hanisch, Tom Herrnsdorf, Tom Hovehne, Alicia Junker, Patricia Kanngiesser, Felipe Villa Larens, Safaa Mahmoud, Sandra Masaquiza, Iino Masato, Risma Illa Maulany, Tongtong Meng, Kardelen Mutlu, Putu Oka Ngakan, Ebru Peközer, Ljubica Petrović, Mirella Christy Rehatalanit Jan 2026

Children And Adults Across 15 Countries Believe In Human Uniqueness Of Mind: A Cross-Cultural Investigation Of Cross-Species Mind Perception, Karri Neldner, Luke Maurits, Magie Junker, Lara Abbas, Nayrouz Abbas, Arianna Abis, Federica Amici, Bernardo Arroyo-Garcia, Negar Asghari, Giovanna Barragán Pardo, Zhen Zhang, Junior Peña Chumacero, Ardain Dzabatou, Dustin Eirdosh, Susan Hanisch, Tom Herrnsdorf, Tom Hovehne, Alicia Junker, Patricia Kanngiesser, Felipe Villa Larens, Safaa Mahmoud, Sandra Masaquiza, Iino Masato, Risma Illa Maulany, Tongtong Meng, Kardelen Mutlu, Putu Oka Ngakan, Ebru Peközer, Ljubica Petrović, Mirella Christy Rehatalanit

School of Psychology

The way humans relate to other animals is fundamentally shaped by whether we perceive ourselves as unique, with feelings and thoughts not shared by other animals. How beliefs about animals’ ability to feel and think develop across cultures remains largely unexplored. We asked children and adolescents (4–17 years, N = 1025) and adults (N = 190) from 33 urban and rural communities across 15 countries whether animals have thoughts or feelings (judgments of presence), and whether those thoughts or feelings are human-like (judgments of similarity). Bayesian analyses revealed that participants generally ascribed non-human animals the ability for thoughts and feelings. …

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Degrees Of Separation: Grandchildren's Experiences Of Grandparental Brain Tumor Or Stroke, Emily Sapsford, Alyson Norman, Sue Jackson, Josh Deacon, Emily Ravenhill, Pete Keohane Jan 2026

Degrees Of Separation: Grandchildren's Experiences Of Grandparental Brain Tumor Or Stroke, Emily Sapsford, Alyson Norman, Sue Jackson, Josh Deacon, Emily Ravenhill, Pete Keohane

School of Psychology

The impact of acquired brain injury on family members is far reaching. Research has identified experiences of trauma, ambiguous loss and burden of care. Limited research has addressed the ripple effect of brain injury across the wider family. The study aimed to gain a detailed insight into the lived experiences of grandchildren of those who have experienced stroke or brain tumor. Ten participants (eight female and two males aged between 18 and 29) took part in semi-structured interviews about their experiences of grandparental stroke or brain tumor. Data were analyzed using interpretive phenomenological analysis (IPA). Four themes were identified. The …

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Integrating Neuroscience And Social Psychology In Researching Interprofessional Education: The Inspire Framework, Kimberley Schenke, Pamela Rae, Jaysan Charlesford, Phil Gee Jan 2026

Integrating Neuroscience And Social Psychology In Researching Interprofessional Education: The Inspire Framework, Kimberley Schenke, Pamela Rae, Jaysan Charlesford, Phil Gee

School of Psychology

There is an increasing focus on the importance of interprofessional education as an integral part of health and social care training. However, the fundamental psychological processes underlying successful interprofessional education are not well understood. Here we propose a single framework, Integrating Neuroscience and Social Psychology In Researching Interprofessional Education (INSPIRE), grounded in evidence from social psychology and neuroscience that could be used to generate testable hypotheses to inform the design, development and evaluation of interprofessional education. The application of this framework offers a novel, scientifically grounded approach to improving the learning outcomes of interprofessional education and provides a foundation for …

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Video Interaction Guidance With Adults With Intellectual Disabilities And Their Support Workers: A Service Evaluation, Áine Maguire, Vicky Anagnostopoulou, Joe Levi-French, Deanna J. Gallichan Jan 2026

Video Interaction Guidance With Adults With Intellectual Disabilities And Their Support Workers: A Service Evaluation, Áine Maguire, Vicky Anagnostopoulou, Joe Levi-French, Deanna J. Gallichan

School of Psychology

Background: This service evaluation focused on support workers' perceptions of Video Interaction Guidance (VIG) offered by an NHS Community Learning Disabilities Team. Methods: A mixed-methods design was employed. Support workers developed goals and rated their progress before and after VIG sessions. Thematic analysis was used to analyse qualitative data on the nature of the goals developed, and the strengths and working points identified. The differences between progress ratings before and after VIG were analysed using the Wilcoxon signed-rank test. Retrospective interviews helped to further understand support workers' experiences of VIG. Findings: Support workers identified goals, strengths and working points that …

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Enhancing Monitoring In Protected Areas: Evaluating Mobile Apps As A Tourism Proxy, Jorge Costa, Alberto Gomes, Martin Stokes, Miguel Saraiva Jan 2026

Enhancing Monitoring In Protected Areas: Evaluating Mobile Apps As A Tourism Proxy, Jorge Costa, Alberto Gomes, Martin Stokes, Miguel Saraiva

School of Geography, Earth and Environmental Sciences

Crowdsourced data, such as that from mobile fitness apps (MFAs), has the potential to transform tourism research. This opportunity is particularly valuable as tourism to protected areas (PAs) increases, making it more difficult to manage their environmental impacts. However, such data sources come with challenges. Therefore, their representativeness should be carefully evaluated, particularly as their use continues to grow. We use the Paiva Walkways (Portugal) to assess MFAs as a tourism proxy using Spearman’s rank correlation, to evaluate kernel density and fishnet methods for spatialising visitor movements, and to analyse the visitors’ spatiotemporal behaviour using GIS, kernel density estimation, and …

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Does In-Bed Cycling Delivered Within 48 Hours Of Mechanical Ventilation, Reduce The Occurrence Of Delirium In Critically Ill Patients: A Mixed-Methods Feasibility Randomised Controlled Trial Protocol, Jacqueline Bennion, Mark Hudson, Mary Hickson, Victoria Allgar, Bridie Kent, David Mcwilliams, Daniel Martin Jan 2026

Does In-Bed Cycling Delivered Within 48 Hours Of Mechanical Ventilation, Reduce The Occurrence Of Delirium In Critically Ill Patients: A Mixed-Methods Feasibility Randomised Controlled Trial Protocol, Jacqueline Bennion, Mark Hudson, Mary Hickson, Victoria Allgar, Bridie Kent, David Mcwilliams, Daniel Martin

Peninsula Medical School

Background: Delirium is a severe neuropsychiatric clinical state presenting as an acute onset of cognitive deficits. Patients receiving invasive mechanical ventilation (IMV), have the highest incidence (50%–80%) of delirium amongst patients admitted to intensive care units. Preliminary data indicates that early mobilisation is associated with reduced delirium in critically ill patients. However, definitive evidence is lacking. Current practice varies due to many barriers to patients, who require IMV, receiving early mobilisation interventions. In-bed cycling may address some of these barriers. This research aims to evaluate the feasibility and acceptability of early in-bed cycling to reduce delirium in critically ill patients. …

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The Effectiveness Of Digital Therapeutics Intervention In Oral Anticoagulation Management: A Systematic Review And Meta-Analysis, Jiayue Guo, Lili You, Lu Liu, Xitong Jiao, Debasish Kar, Jitendra Jonnagaddala Jan 2026

The Effectiveness Of Digital Therapeutics Intervention In Oral Anticoagulation Management: A Systematic Review And Meta-Analysis, Jiayue Guo, Lili You, Lu Liu, Xitong Jiao, Debasish Kar, Jitendra Jonnagaddala

Peninsula Medical School

Objective: To summarize the key intervention characteristics and evaluate the effectivenessand safety of digital therapeutics (DTx) in patients receiving oral anticoagulation, witheffectiveness evaluated using time in therapeutic range (TTR), thromboembolic events (TEE),and mortality, and safety evaluated based on bleeding events.Patients and Methods: We searched PubMed, Embase, Web of Science, and the CochraneLibrary from inception to June 20, 2025, and identified ten randomized controlled trialsinvolving 7,237 patients. The criteria required studies to assess software-based DTxsupporting anticoagulation management and report effectiveness or safety outcomes. Studyquality was evaluated using the Grading of Recommendations, Assessment, Development,and Evaluation (GRADE) framework, and random-effects models were applied.Results: …

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Patient And Practitioner Workshops For An Intellectual Disabilities And Epilepsy Neuropsychiatric Genetic Research Database Register: Ethical Dilemmas For Study Design, Rohit Shankar, Jon Allard, Dannielle Bilkey, Brendan Mclean, Pamela Bowman, Chloe Staples, Lance Watkins, Anna Simpson, Elizabeth Boardman, Sarah Mitchell, Sarah Lennard Jan 2026

Patient And Practitioner Workshops For An Intellectual Disabilities And Epilepsy Neuropsychiatric Genetic Research Database Register: Ethical Dilemmas For Study Design, Rohit Shankar, Jon Allard, Dannielle Bilkey, Brendan Mclean, Pamela Bowman, Chloe Staples, Lance Watkins, Anna Simpson, Elizabeth Boardman, Sarah Mitchell, Sarah Lennard

Peninsula Medical School

BackgroundThere is a need for more research studies focussed on People with ID (PwID) and Epilepsy and for the design of these studies to be shaped by this complex and vulnerable population and those who care for and support them.AimsTo develop understanding as to how a future NHS genetic research database register for PwID and Epilepsy should be conducted in a way which is inclusive, suitable and appropriate for them, their carers and the NHS settings where the research would be undertaken.MethodsThree workshops were completed with 17 formal participants: (1) PwID and Epilepsy (n2); (2) carers of PwID and Epilepsy …

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Prevalence And Determinants Of Diabetes-Related Psychological Distress In A Tertiary Care Setting In Tamil Nadu: India: Cross-Sectional Study, Rohit Shankar, Samuel Tromans Jan 2026

Prevalence And Determinants Of Diabetes-Related Psychological Distress In A Tertiary Care Setting In Tamil Nadu: India: Cross-Sectional Study, Rohit Shankar, Samuel Tromans

Peninsula Medical School

BackgroundDiabetes distress, whereby people with diabetes experience distressing psychological symptoms associated with living with their condition, is an emerging problem in India. Diabetes distress leads to self-care deficits, suboptimal glycaemic control (which can lead to increasing risks of complications) and impaired quality of life.AimsTo determine the burden of diabetes distress and its associated factors in an Indian tertiary care centre in Trichy, Tamil Nadu, India, covering a population of 1.25 million.MethodThis prospective observational study involved a structured questionnaire covering demographic and clinical details, which was given to patients. The Diabetes Distress Scale 17 (DDS-17) was used to assess diabetes distress …

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Involving Parents In Prevention: A Case Example Of Research And Intervention Development To Improve Financial Well-Being Support, Nick Axford, Gisella Hanley, Rebecca Summers, Kristin Liabo, Amy Bond, Eleanor Bryant, Georgia Smith, Rachel Silcock, Vashti Berry Jan 2026

Involving Parents In Prevention: A Case Example Of Research And Intervention Development To Improve Financial Well-Being Support, Nick Axford, Gisella Hanley, Rebecca Summers, Kristin Liabo, Amy Bond, Eleanor Bryant, Georgia Smith, Rachel Silcock, Vashti Berry

Peninsula Medical School

The adverse effects on parent and child outcomes of poverty and stressors associated with low income are well established. With notable exceptions, however, the potential role of frontline services in improving family financial well-being is underexplored. This article outlines how patient and public involvement (PPI) was initiated early on in research on financial well-being support (FWbS). It illustrates how research can build on and integrate what parents say about services and how to research them. The involvement work was undertaken in one city in part to inform the adaptation of an income maximisation service to be delivered in local children’s …

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Microplastics, Nanoplastics And Liver Disease: An Emerging Health Concern?, Shilpa Chokshi, Ashwin Dhanda, Matthew E. Cramp, Richard Thompson Jan 2026

Microplastics, Nanoplastics And Liver Disease: An Emerging Health Concern?, Shilpa Chokshi, Ashwin Dhanda, Matthew E. Cramp, Richard Thompson

Peninsula Medical School

Human liver tissue has been found to contain microplastics and nanoplastics (MNPs), with evidence that hepatic MNP accumulation has markedly increased over the past 10 years, prompting critical questions regarding their potential causal role in liver disease. In cell-based and murine models, MNP exposure can trigger oxidative stress, fibrogenesis and inflammation, pathological features that resemble those of advanced liver disease, suggesting shared mechanistic pathways. Furthermore, the capacity for MNPs to act as vectors for microbial pathogens, antimicrobial resistance, endocrine-disrupting chemicals and carcinogenic additives might have important implications for liver pathology. This Perspective examines emerging evidence on the consequences of MNPs …

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Designing A Mobile App For Post Traumatic Stress Disorder: Insights From Lived Experience And Clinical Practice, Rohit Shankar, Richard Laugharne, Michael Loizou, Marius Varga, Sivia Lin, Bojana Daw Srdanovic, Roger Farrell Jan 2026

Designing A Mobile App For Post Traumatic Stress Disorder: Insights From Lived Experience And Clinical Practice, Rohit Shankar, Richard Laugharne, Michael Loizou, Marius Varga, Sivia Lin, Bojana Daw Srdanovic, Roger Farrell

Peninsula Medical School

Post-traumatic stress disorder (PTSD) is a disabling anxiety disorder precipitated by severe trauma. Many people with this condition have little access to clinical interventions, especially in low-middle-income countries. For the development of any digital health intervention, it is vital to know the opinions of PLE and clinicians to guide the developers. We conducted two focus groups, one with clinicians (n = 5) and one with people with lived experience (PLE) (n = 11), to gain knowledge of their views on the development of a PTSD App. Transcripts of both focus groups were coded and thematically analysed. The key themes that …

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Royal College Of Psychiatrists College Report 244: Optimising Psychotropic Medication Prescribing For People With Intellectual Disability, Rohit Shankar Jan 2026

Royal College Of Psychiatrists College Report 244: Optimising Psychotropic Medication Prescribing For People With Intellectual Disability, Rohit Shankar

Peninsula Medical School

No abstract provided.

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Investigating The Potential For First Year Residential Field Courses To Facilitate The Establishment Of Teacher-Student Relationships In Biological Sciences Undergraduate Degrees, Anne Plessis, Alison Stokes Jan 2026

Investigating The Potential For First Year Residential Field Courses To Facilitate The Establishment Of Teacher-Student Relationships In Biological Sciences Undergraduate Degrees, Anne Plessis, Alison Stokes

School of Biological and Marine Sciences

Teacher-student relationships (TSRs) in higher education impact many aspects of the student experience, including engagement and performance. However, relatively little is known about the mechanisms of establishment of TSRs, and in particular how these are influenced by specific learning environments and contexts. Here, we undertake an exploratory investigation using first year biological sciences undergraduate residential field courses to examine how this teaching context affected the frequency and nature of teacher student interactions, and consequently the development of TSRs. Data were collected from teacher and student participants using questionnaires and focus groups. We found that interactions during fieldwork took place frequently …

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Gelatinous Zooplankton As Indicators In The Kunming Montreal Global Biodiversity Framework, John Terenzini, Laura J. Falkenberg, Sanae Chiba, Matthew Faith, Robert Puschendorf, Abigail Mcquatters-Gollop Jan 2026

Gelatinous Zooplankton As Indicators In The Kunming Montreal Global Biodiversity Framework, John Terenzini, Laura J. Falkenberg, Sanae Chiba, Matthew Faith, Robert Puschendorf, Abigail Mcquatters-Gollop

School of Biological and Marine Sciences

Global biodiversity frameworks require robust, representative indicators to effectively track progress towards conservation targets. Spatial and temporal gaps in global marine biodiversity datasets, however, and a limited number of marine biodiversity indicators, limit our ability to effectively manage marine ecosystems. Despite the ecological and socio-economic significance of marine ecosystems, they remain underrepresented in current indicator suites, particularly in the recently adopted Kunming-Montreal Global Biodiversity Framework (KMGBF). Gelatinous zooplankton (GZ), a key yet often overlooked component of marine ecosystems, have the potential to strengthen biodiversity assessments through their responsiveness to environmental change and impacts on several contributions of the ocean to …

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Testing The Transferability Of Ai Models For Cold-Water Coral Detection And Classification, Kyran P. Graves, Louise Allcock, David K.A. Barnes, Amelia E.H. Bridges, Kerry L. Howell Jan 2026

Testing The Transferability Of Ai Models For Cold-Water Coral Detection And Classification, Kyran P. Graves, Louise Allcock, David K.A. Barnes, Amelia E.H. Bridges, Kerry L. Howell

School of Biological and Marine Sciences

The proliferation of accessible deep-water imaging platforms has resulted in the acquisition of vast amounts of image data, resulting in an analysis bottleneck. Object detection is now being applied to assist the image annotation process, with the potential to reduce analysis time. However, for object detectors to effectively tackle the scale of the challenge, models need to be generalisable to allow the transfer between imaging platforms and in space. This study trains YOLOv5 object detection models to identify six coral morphology groups using annotated imagery collected by ROV ISIS in the UK (JC136). Model performance was tested with independent datasets …

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The Ideological Work Of Penal Reform: How Reformers Justify Penal-Welfare Hybridization, John Halushka, Brandon Miller Jan 2026

The Ideological Work Of Penal Reform: How Reformers Justify Penal-Welfare Hybridization, John Halushka, Brandon Miller

Faculty Research, Scholarly, and Creative Activity

This article uses the Santa Clara County Reentry Resource Center (RRC) as a case study to explore the cultural content of penal reform. Specifically, we explore the discourses that officials use to publicly justify projects of penal-welfare hybridization, or the linking of state systems of punishment and welfare to manage criminalized populations. Our qualitative analysis draws on a dataset consisting of county planning documents, budgets, videos, press releases, and newsletters published online between 2011 and 2023. By examining these materials over time, we are able to chart patterns of consistency and variation in how officials justify hybridization. We find that …

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Epithelial-Mesenchymal Transition And Stress Adaptations Underlie Yttrium-90 Resistance In Liver Cancer Cell Lines, Alexander Zheleznyak, Dhanusha Duraiyan, Prasanth Thunuguntla, Jessica Camacho, Shuang Wu, Jingxia Liu, Jason D Weber, Daniel L J Thorek, Benjamin S Strnad, Ryan C Fields, Matthew A Ciorba, Christine Yoon, Valerie Blanc, Nicholas Davidson, Jessica Silva-Fisher, Christopher D Malone Jan 2026

Epithelial-Mesenchymal Transition And Stress Adaptations Underlie Yttrium-90 Resistance In Liver Cancer Cell Lines, Alexander Zheleznyak, Dhanusha Duraiyan, Prasanth Thunuguntla, Jessica Camacho, Shuang Wu, Jingxia Liu, Jason D Weber, Daniel L J Thorek, Benjamin S Strnad, Ryan C Fields, Matthew A Ciorba, Christine Yoon, Valerie Blanc, Nicholas Davidson, Jessica Silva-Fisher, Christopher D Malone

2020-Current year OA Pubs

UNLABELLED: Molecular signatures predict prognosis in hepatocellular carcinoma, but their relevance to transarterial radioembolization (TARE) with yttrium-90 (90Y) is unknown. We aimed to identify baseline and treatment-induced pathways associated with response and nominate biomarkers. Ten transcriptomically diverse human liver cancer cell lines were exposed to escalating activities of glass 90Y microspheres for 10 days. Normalized AUC values quantified sensitivity. Whole-transcriptome RNA sequencing at baseline and after treatment was analyzed with elastic net regression and gene set enrichment. Findings were corroborated by qRT-qPCR and exploratory analysis of pretreatment tumor samples from patients undergoing TARE. Liver cancer cell line responses to 90Y …

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A Single-Cell Atlas Characterizes Dysregulation Of The Bone Marrow Immune Microenvironment Associated With Outcomes In Multiple Myeloma, William C Pilcher, Lijun Yao, Yizhe Song, Kazuhito Sato, Julia T Wang, Reyka G Jayasinghe, Jennifer A Foltz, Mark A Fiala, Chiang I-Ling, Julie Fortier, Michael Slade, Stephen T Oh, Michael P Rettig, John F Dipersio, Shaji Kumar, Ravi Vij, Li Ding, Et Al. Jan 2026

A Single-Cell Atlas Characterizes Dysregulation Of The Bone Marrow Immune Microenvironment Associated With Outcomes In Multiple Myeloma, William C Pilcher, Lijun Yao, Yizhe Song, Kazuhito Sato, Julia T Wang, Reyka G Jayasinghe, Jennifer A Foltz, Mark A Fiala, Chiang I-Ling, Julie Fortier, Michael Slade, Stephen T Oh, Michael P Rettig, John F Dipersio, Shaji Kumar, Ravi Vij, Li Ding, Et Al.

2020-Current year OA Pubs

Multiple myeloma (MM) remains incurable despite advances in treatment options. Although tumor subtypes and specific DNA abnormalities are linked to worse prognosis, the impact of immune dysfunction on disease emergence and/or treatment sensitivity remains unclear. We developed an Immune Atlas of MM by generating profiles of 1,397,272 single cells from the bone marrow (BM) of 337 newly diagnosed participants and characterized immune and hematopoietic cell populations. Cytogenetic risk-based analysis revealed heterogeneous associations with T cells of BM, with 17p13 deletion showing distinct enrichment of a type 1 interferon signature. The disease progression-based analysis revealed the presence of a proinflammatory immune …

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Fairrfl: Fair And Robust Federated Learning In The Presence Of Selfish Clients, Andrea Augello, Ashish Gupta, Giuseppe Lo Re, Sajal K. Das Jan 2026

Fairrfl: Fair And Robust Federated Learning In The Presence Of Selfish Clients, Andrea Augello, Ashish Gupta, Giuseppe Lo Re, Sajal K. Das

Computer Science Faculty Research & Creative Works

Federated Learning (FL) is a paradigm that enables collaborative machine learning without disclosing the local data of the participants. However, in real-world FL deployment scenarios, some unscrupolous clients may alter the training process to skew the global model towards their local optimum, unfairly prioritizing their data distribution. Their influence can degrade overall model performance for normal clients and reduce fairness in the system. We call this novel category of misbehaving clients 'selfish'. This work proposes a Fair and Robust strategy for aggregation in the Federated Learning (FL) server to mitigate the effect of Selfish clients (FairRFL). FairRFL incorporates a novel …

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Smartflow: A Communication-Efficient Sdn Framework For Cross-Silo Federated Learning, Osama Abu Hamdan, Hao Che, Engin Arslan, Md Arifuzzaman Jan 2026

Smartflow: A Communication-Efficient Sdn Framework For Cross-Silo Federated Learning, Osama Abu Hamdan, Hao Che, Engin Arslan, Md Arifuzzaman

Computer Science Faculty Research & Creative Works

Cross-silo Federated Learning (FL) enables multiple institutions to collaboratively train machine learning models while preserving data privacy. In such settings, clients repeatedly exchange model weights with a central server, making the overall training time highly sensitive to network performance. However, conventional routing methods often fail to prevent congestion, leading to increased communication latency and prolonged training. Software-Defined Networking (SDN), which provides centralized and programmable control over network resources, offers a promising way to address this limitation. To this end, we propose SmartFLow, an SDN-based framework designed to enhance communication efficiency in cross-silo FL. SmartFLow dynamically adjusts routing paths in response …

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Utility-Preserving Federated Graph Learning With Dual-Perspective Fairness, Renqiang Luo, Huafei Huang, Shuo Yu, Fengqi Yu, Feng Xia, Sajal K. Das, Chengqi Zhang Jan 2026

Utility-Preserving Federated Graph Learning With Dual-Perspective Fairness, Renqiang Luo, Huafei Huang, Shuo Yu, Fengqi Yu, Feng Xia, Sajal K. Das, Chengqi Zhang

Computer Science Faculty Research & Creative Works

Fairness-aware federated graph neural networks (FedGNNs) necessitate consideration of both the server and the clients. However, fairness-aware methods struggle to enhance dual-perspective (i.e., server and clients) fairness without sacrificing utility due to the distributed learning framework. As a consequence, the utility sacrifices of fairness-aware graph learning methods are even exacerbated in federated frameworks. In this work we propose F3GL, a dual-perspective fairness federated graph learning method that enhances both global (for the server) and local fairness (for clients) while preserving utility. Through theoretical analysis, we delineate the similarity between original sensitive features and those after convolution under different spectra. Our …

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Establishing And Testing Experiential Critical Theory (Ect), Dolores M. Batten Mrs. Jan 2026

Establishing And Testing Experiential Critical Theory (Ect), Dolores M. Batten Mrs.

Graduate Studies Theses and Dissertations 2026

There is a current gap in academia which has been largely overlooked in both pedagogy and assessment: the value of personal experience as key evidence of interpretation and meaning-making correlation. Aside from narrative writing, most current methods of literary analysis writing do not place a high value on personal experience beyond the inclusion of brief anecdotes. Yet experience is the major pathway by which an individual forms their worldview, which then informs the ways in which they interpret the world—and by extension, text. This dissertation both establishes and examines the use of Experiential Critical Theory (ECT) in pedagogical application for …

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Reflection In Still Waters: Generative Ai's Production Of Language, Jonathan D. Hawks Jan 2026

Reflection In Still Waters: Generative Ai's Production Of Language, Jonathan D. Hawks

Graduate Studies Theses and Dissertations 2026

Language is a conceptual process of meaning-making as well as a social construction as defined by Saussure, Bakhtin, and Lacan. Large Language Models (LLMs) engage with neither process and instead present language as a finished and consumable product which undermines its fundamental aspects. The difference between representing language through probability and its structural components instead of its more inherent qualities is not a pointless distinction. This paper utilizes Narcissus as a central metaphor to show how people misread the outputs of LLMs as language which imparts to those reflected words meaning on par with our own conceptualizations of reality. People …

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