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Articles 3361 - 3390 of 41050
Full-Text Articles in Entire DC Network
Resonating Or Missing The Mark? Indigenous Students’ Perspectives On University Marketing Communications, Melissa Fong-Emmerson, Claire Lambert, Braden Hill, Maria M. Ryan
Resonating Or Missing The Mark? Indigenous Students’ Perspectives On University Marketing Communications, Melissa Fong-Emmerson, Claire Lambert, Braden Hill, Maria M. Ryan
Research outputs 2022 to 2026
This study explores the perspectives of Indigenous Australian students on the marketing and communication materials of higher education institutions, highlighting their crucial role in attracting Indigenous students and revealing a lack of authentic engagement with Indigenous voices. While outreach and enabling programs have boosted participation, a significant gap remains in research on marketing and communication strategies that resonate with Indigenous students. This is especially relevant in the context of the Universities Australia Indigenous Strategy 2022–25 and the Australian Universities Accord, which aim to enhance Indigenous participation. Drawing on three yarning sessions with 15 students, this research identifies a disconnect between …
20260904: University Communications, 1938-1990, University Communications
20260904: University Communications, 1938-1990, University Communications
Guides to University Archives
These items include materials from the office of University Communications at Marshall University from 1938-1990s. Items were received at a much earlier date and include notable materials such as New Faculty lists, Training for Engineering at Marshall, Office Directories, and Marshall University Fact Book. Please see the inventory for a full list of details.
Developing The Social And Legal Competence Of Future Social Counselors, Lazzat Suleimenova, Saira Zhiyenbayeva, Kamchat Yessenova, Yernar Onalbekov, Elmira Bayarystanova
Developing The Social And Legal Competence Of Future Social Counselors, Lazzat Suleimenova, Saira Zhiyenbayeva, Kamchat Yessenova, Yernar Onalbekov, Elmira Bayarystanova
Higher Learning Research Communications
Objectives: The social and legal (also referred to as sociolegal) competence of future social counselors is one of the key factors that ensures the effectiveness of their professional activities—protecting the rights of the individual, collaborating with other professionals, and contributing to the creation of a safe social environment. The study aimed to create and implement a model and pedagogical conditions for the development of sociolegal competence of future social counselors in higher education institutions of the Republic of Kazakhstan.
Methods: As part of a study conducted at L.N. Gumilyov Eurasian National University, Faculty of Social Sciences, in the social pedagogy …
Implementation Of A Learning Module To Reduce Advanced Practice Provider Preceptor Burden, Michelle Bloom
Implementation Of A Learning Module To Reduce Advanced Practice Provider Preceptor Burden, Michelle Bloom
Doctor of Nursing Practice (DNP) Student Projects
The transition of advanced practice providers (APPs) from student to provider, or from an experienced provider to a new organization or location, has been identified as a high-stress period with potential turnover for new-hire APPs. APP preceptors play a key role in this transition. Limited time to teach during the clinical day and a limited knowledge base among new hires were two of many factors associated with increased preceptor burden. A brief online educational module that provided pre-clinical, organization-specific education was proposed to improve new-hire APPs’ knowledge base and reduce preceptor burden, among APP preceptors working in a 36-bed surgical/burn/trauma …
Leading From The Precipice: How Academic Deans Are Navigating Artificial Intelligence In Higher Education, V. Dozier, Sarina Chugani Molina
Leading From The Precipice: How Academic Deans Are Navigating Artificial Intelligence In Higher Education, V. Dozier, Sarina Chugani Molina
Copley Library: Faculty Scholarship
This qualitative case study examines how associate deans at a medium-sized Catholic university respond to the rapid integration of generative artificial intelligence (AI). Guided by decolonial and feminist frameworks, the study analyzes survey data from seven academic leaders to understand their concerns, decision-making processes, and emerging practices. Our findings reveal uneven adoption, limited institutional guidance, and ongoing concerns about academic integrity, equity, and bias. The study also highlights the often-unseen relational and emotional labor involved in supporting faculty and students. We conclude by recommending flexible, collaborative approaches to AI governance that attend to context, care, and diverse ways of knowing.
The Unstoppable Wheel Of Design History: A Cycle Of Perception And Production En [Ponencia] Design In An Age Of Uncertainty, Design History Society Annual Conference 2026, Jorge Fragua Valdivieso
The Unstoppable Wheel Of Design History: A Cycle Of Perception And Production En [Ponencia] Design In An Age Of Uncertainty, Design History Society Annual Conference 2026, Jorge Fragua Valdivieso
Congresos y Conferencias
In an era of political, ecological and epistemic uncertainty, design his tory is frequently employed to lend legitimacy to optimistic narratives of progress, or to provide readymade references for contemporary practice and education. However, this text argues that such approach es reduce historical knowledge to a linear and instrumental resource, thereby obscuring its role within longer and more complex cycles of per ception and production. Here, the historical process is examined as an iterative cycle that en compasses both material production and perception. Building on the work of David Walker and Nigel Cross, the analysis considers how ma terial production …
Dimensions Of Father-Love Absence As Predictors Of Psychological Well-Being: Evidence From University Students, Dody Hartanto, Mufied Fauziah, Zerlinda Aurora Saputri
Dimensions Of Father-Love Absence As Predictors Of Psychological Well-Being: Evidence From University Students, Dody Hartanto, Mufied Fauziah, Zerlinda Aurora Saputri
Jurnal Kajian Bimbingan dan Konseling
Psychological well-being is a crucial aspect of university students' development as young adults. Father-love absence is believed to be one of the factors influencing this well-being. This study aimed to analyze the role of father-love absence as a predictor of university students' psychological well-being and to identify the contribution of each aspect of father-love absence. A quantitative approach with a descriptive correlational design was employed. A total of 318 active university students were selected through simple random sampling and completed an online questionnaire. Father-love absence was measured using an adapted scale based on Xiang and Zhou's theory, encompassing four aspects: …
Discovering Repurposable Drugs For Alzheimer's Disease And Related Dementias: Target Trial Emulation Using Decentralised Real-World Data, Qiong Wu, Lu Li, Yuqing Lei, Ting Zhou, Huilin Tang, Bingyu Zhang, Yiwen Lu, Maxwell Salvatore, Dazheng Zhang, Jiayi Tong, Tingyin Wang, Siqi Chen, Haoyang Li, Zhenxing Xu, Yu Huang, Yu Hu, Na Hong, Yujia Zhou, Fongci Lin, Kyra O'Brien, Yong Chen, Ruowang Li, Hua Xu, Fei Wang, Jiang Bian, David Wolk, Yong Chen
Discovering Repurposable Drugs For Alzheimer's Disease And Related Dementias: Target Trial Emulation Using Decentralised Real-World Data, Qiong Wu, Lu Li, Yuqing Lei, Ting Zhou, Huilin Tang, Bingyu Zhang, Yiwen Lu, Maxwell Salvatore, Dazheng Zhang, Jiayi Tong, Tingyin Wang, Siqi Chen, Haoyang Li, Zhenxing Xu, Yu Huang, Yu Hu, Na Hong, Yujia Zhou, Fongci Lin, Kyra O'Brien, Yong Chen, Ruowang Li, Hua Xu, Fei Wang, Jiang Bian, David Wolk, Yong Chen
College of Population Health Faculty Papers
BACKGROUND: Alzheimer's disease and related dementias (ADRD) affect nearly 6.9 million Americans, with the number expected to triple by 2050, while disease-modifying therapies remain unavailable. Drug repurposing, which identifies new indications for already approved medications, offers a more efficient and cost-effective pathway to accelerate development of effective therapies for ADRD. The aim of this study is to identify potential drug repurposing signals by systematically screening routinely prescribed drugs for associations with progression from mild cognitive impairment (MCI) to ADRD.
METHODS: We conducted a multi-site target trial emulation using electronic health record (EHR) data from four decentralised databases: INSIGHT Clinical Research …
Immigrant Women’S Experiences Of Living In An Abusive Relationship: A Narrative Inquiry, Fay M. Dastjerdi, Sassan Issari, Zipora Rahmanov, Elizabeth Sombilon
Immigrant Women’S Experiences Of Living In An Abusive Relationship: A Narrative Inquiry, Fay M. Dastjerdi, Sassan Issari, Zipora Rahmanov, Elizabeth Sombilon
International Nursing Research Congress (INRC)
Immigration has become a reality in most parts of the world for different reasons. Iranian immigrants ranked sixth in acquiring Canadian citizenship and eighth in being admitted as permanent residents (Bains, 2024; Risdon, 2024). Most immigrants experience some degree of loss and disassociation after being dislocated. Intimate Partner Violence (IPV) impacts people of all genders, ages and socioeconomic, racial, educational, ethnic, religious and cultural backgrounds; however,women experience this form of gender-based violence at much higher rates, most often perpetrated by men (Statistics Canada, 2023 & 2025). IPV presents a significant public health challenge affecting diverse demographic groups, including immigrant women …
Advance Care Planning In Practice: Hospital Nurses’ Experiences With Known And Unknown Goals Of Care, Ashley Hebert, Genevieve Thompson, Diana Mcmillan, Katarina Lee-Ameduri
Advance Care Planning In Practice: Hospital Nurses’ Experiences With Known And Unknown Goals Of Care, Ashley Hebert, Genevieve Thompson, Diana Mcmillan, Katarina Lee-Ameduri
International Nursing Research Congress (INRC)
Background: Hospital continues to be the place of death for the majority of Canadians, despite the common preference for a less aggressive comfort-focused plan of care at the end-of-life. Advance care planning (ACP) is recognized as a means to prevent unwanted care for patients. However, ACP is often not occurring in acute care settings before patients lose the capacity to participate. This means that a patient’s goals of care are frequently left unknown, which may not only lead to overtreatment and patient harm, but also to moral distress in nurses.
Purpose: The purpose of this thesis study is (1) to …
Comparative Experimental Investigation Of Corrugated Solar Air Heater Using Porous Media And Twisted Tapes, Hussam J. Rashid, Mohammed K. Al-Saadi, Ameer Jaddoa
Comparative Experimental Investigation Of Corrugated Solar Air Heater Using Porous Media And Twisted Tapes, Hussam J. Rashid, Mohammed K. Al-Saadi, Ameer Jaddoa
Engineering and Technology Journal
This experimental work examines the thermal, thermohydraulic, and exergetic performance of a modified revised multi duct solar air heater (SAH) under real outdoor conditions. Four configurations were examined, including a smooth collector, ducts with corrugation, porous-lined ducts, and corrugated ducts equipped with inserted twisted tapes over the investigated Reynolds number (Re) interval (2000–10,000). The airflow was supplied by a DC fan powered directly by photovoltaic modules. Introducing internal flow-modifying elements resulted in a marked enhancement of the SAH heat transfer capability, as confirmed by the experimental observations. When compared to the smooth absorber, among the tested configurations, the twisted tape …
Low Rates Of Smoking Cessation Medication Prescriptions And Evidence To Support Increased Medication Utilization, Jesse Pratt
Low Rates Of Smoking Cessation Medication Prescriptions And Evidence To Support Increased Medication Utilization, Jesse Pratt
SIU Journal of Medical Science Scholarly Works
ABSTRACT
Introduction: Tobacco use remains a major cause of morbidity and mortality in the United States. Over the past several decades, there has been a steady decline in tobacco use, however overall use remains unacceptably high. Despite recommendations to treat people with tobacco use disorder with smoking cessation medications (SCMs), prescriptions for SCMs remain low.
Methods: A PubMed search was conducted using search terms “adult”, “smoking cessation”, “medication”, “varenicline”, “nicotine”, and “bupropion”. Filters included publication dates within ten years, and full text. Search results yielded 109 articles. Thirteen articles were selected for the review. The articles chosen either discussed prescribing …
The Impact Of A Modified Hospital Elder Life Program On Delirium, Ashley Okray
The Impact Of A Modified Hospital Elder Life Program On Delirium, Ashley Okray
SIU Journal of Medical Science Scholarly Works
Background: Delirium, an acute state of fluctuating inattention and cognitive impairment, is prevalent among hospitalized older adults and associated with longer hospital stays, increased mortality, and significant healthcare costs. The Hospital Elder Life Program (HELP) was developed to reduce delirium through interventions addressing common risk factors. Although HELP has proven effective, many hospitals face challenges in implementing the program, leading to modified versions. This review examines recent studies using modified HELP to assess their impact on delirium prevention.
Methods: A literature search was conducted to identify studies from the last ten years that implemented modified HELP programs. Relevant studies …
Preparation Of Physician Assistant Students To Manage Patients Living With Hiv/Aids In A Primary Care Setting, Austin Parrish
Preparation Of Physician Assistant Students To Manage Patients Living With Hiv/Aids In A Primary Care Setting, Austin Parrish
SIU Journal of Medical Science Scholarly Works
This study examined Human Immunodeficiency Virus (HIV), Acquired Immunodeficiency Syndrome (AIDS), Pre-Exposure Prophylaxis (PrEP), and Post-Exposure Prophylaxis (PEP) educational exposure among clinical-phase physician assistant (PA) students and evaluated how well current curricula prepare future providers for HIV prevention and care. A cross-sectional survey of 109 PA students assessed HIV-related knowledge, clinical exposure, and awareness of key public health concepts, while lecture materials from 30 PA programs were analyzed for curricular content. Students demonstrated moderate but incomplete baseline knowledge, and fewer than one-quarter reported observing PrEP prescribing during primary care rotations. Awareness of Undetectable = Untransmittable (U=U) was limited, with only …
Genesis And Structure Of Hegel's Phenomenology Of Spirit, Jean Hyppolite
Genesis And Structure Of Hegel's Phenomenology Of Spirit, Jean Hyppolite
Hannah Arendt Marginalia - All
No abstract provided.
Government Censorship In Comedy, Campbell E. Gavin
Government Censorship In Comedy, Campbell E. Gavin
The Dialogue
This paper examines the role of public administration in shaping and restricting comedic expression in the United States, specifically focusing on the FCC’s regulation of broadcast media, targeting stand-up comedians and late-night show hosts. By applying Weber's and Wilson's theories of bureaucracy the paper analyzes how administrative power influences the boundaries of acceptable speech, through legal frameworks and discourse theory. An important court case involving governmental regulation of comedic speech was the FCC v. Pacifica Foundation. This case sets the stage for administrative power to grow in terms of limiting freedom of speech and paving the way for new administrations, …
Advancing A Familial Understanding Of International Students, Prof-Collins Ifeonu Dr
Advancing A Familial Understanding Of International Students, Prof-Collins Ifeonu Dr
Critical Internationalization Studies Review
No abstract provided.
From Readiness To Transformation: The Mediating Role Of Digital Maturity In Linking Ai Readiness To Organizational Change In Hospitals, Muhammad Ryan Adi Putra, Giovanni Reynaldo, Dewi Sri Surya Wuisan
From Readiness To Transformation: The Mediating Role Of Digital Maturity In Linking Ai Readiness To Organizational Change In Hospitals, Muhammad Ryan Adi Putra, Giovanni Reynaldo, Dewi Sri Surya Wuisan
Journal of Health Research
Background: Organizational readiness is essential for AI-enabled digital transformation as healthcare organizations increasingly integrate artificial intelligence (AI). However, empirical evidence regarding the relationship between AI readiness and organizational change, the mediating role of digital maturity, remains limited in healthcare settings. This study investigated the mediating role of digital maturity in the relationship between AI readiness and organizational change.
Methods: This cross-sectional study involved 300 healthcare professionals from two Indonesian hospitals: Persahabatan Hospital (n = 165) and St. Carolus Hospital (n = 135). Data were collected using a questionnaire and analyzed through Partial Least Squares Structural Equation Modeling (PLS-SEM) to assess …
Impact Of The Widespread Use Of Online Pharmacies On Overall Consumer Safety, Hasanain Am. Abbas, Eswar Kumar Kilari, Shereen M. Mekkey, Hussein Ahmed Jabbar, Mohammed Haider Majid, Haider Majeed Abd Abbas, Hassanein Khaled Hassan
Impact Of The Widespread Use Of Online Pharmacies On Overall Consumer Safety, Hasanain Am. Abbas, Eswar Kumar Kilari, Shereen M. Mekkey, Hussein Ahmed Jabbar, Mohammed Haider Majid, Haider Majeed Abd Abbas, Hassanein Khaled Hassan
Al-Mustaqbal Journal of Pharmaceutical and Medical Sciences
Online pharmacies improve access to medicines by offering convenient ordering and home delivery, but their growth also creates important risks for medication safety and public health. This review examines the benefits and hazards associated with online medicine supply, including access without a valid prescription, falsified and substandard products, inappropriate medicine use, privacy breaches, and weak cross-border regulatory oversight. The available evidence indicates that illicit online sellers can expose consumers to products of uncertain identity, quality, and dose, while vulnerable users may have limited ability to distinguish legitimate services from unlawful vendors. At the same time, licensed platforms can support continuity …
System And Method For Provenance-Gated Vector Embedding: Structural Exclusion Of Shadow Inference Records From Production Ai Knowledge Bases, Durga S. Kala, Tianyi Xu, Ketaki Surendra Kumbharkar, Jun Xu
System And Method For Provenance-Gated Vector Embedding: Structural Exclusion Of Shadow Inference Records From Production Ai Knowledge Bases, Durga S. Kala, Tianyi Xu, Ketaki Surendra Kumbharkar, Jun Xu
Defensive Publications Series
The present disclosure relates to a method and a system for maintaining provenance-based separation of Artificial Intelligence (AI) inference data. The present disclosure suggests receiving an inference result record generated by an artificial intelligence (AI) inference platform. The present disclosure also suggests identifying a provenance attribute associated with the inference result record, the provenance attribute indicating an execution context of the artificial intelligence model. Based on the provenance attribute, the present disclosure suggests determining whether the inference result record corresponds to a production execution mode, a shadow execution mode, or an unrecognized execution mode. Upon determination, the present disclosure suggests …
Corrosion Inhibition By Carboxymethyl Cellulose Doped With Graphite Nanosheet And Silica Nanoparticles In Seawater Environment, Mohamed R. Mohssen, Sinan S. Hamdi, Rana A. Anaee, Mathew T. Mathew
Corrosion Inhibition By Carboxymethyl Cellulose Doped With Graphite Nanosheet And Silica Nanoparticles In Seawater Environment, Mohamed R. Mohssen, Sinan S. Hamdi, Rana A. Anaee, Mathew T. Mathew
Engineering and Technology Journal
This work aims to inhibit carbon steel surface as pipelines by adding carboxymethyl cellulose (CMC) with three concentrations (1, 3 and 5 g/L) in seawater environment at four temperatures in the range of 298 – 328 K. The investigation was done by recording Tafel plots and EIS curves to show that the lowest concentration is the best to protect the steel surface with efficiencies ranged between 95.68 – 89.36 % that decrease with increasing temperature due to the decomposition of CMC that begin after ≈ 308 K. An attempt to enhance the protection by CMC at higher temperature has been …
Archival Encounters Across The Disciplines: Using Primary Sources In The Classroom, Karen Morse
Archival Encounters Across The Disciplines: Using Primary Sources In The Classroom, Karen Morse
Faculty Learning Day 2026
Incorporating primary source activities into class sessions can (re)invigorate the classroom while supporting course learning outcomes and critical thinking. This session will highlight activities and assignments successfully deployed in diverse URI courses. Encouraging a DIY approach, it will also include an overview of the tools available to assist instructors with classroom integration (including sources of preexisting lessons) as well as guidance on how and where to find the perfect primary source for your class. Resources provided.
Red Light Accelerates Adventitious Root Primordium Initiation And Differentiation In Phoebe Bournei Cuttings By Modulating Auxin Signaling And Hormonal Balance, Yuewang Niu, Yuanyang Bi, Chenyu Gong, Shipin Chen
Red Light Accelerates Adventitious Root Primordium Initiation And Differentiation In Phoebe Bournei Cuttings By Modulating Auxin Signaling And Hormonal Balance, Yuewang Niu, Yuanyang Bi, Chenyu Gong, Shipin Chen
Turkish Journal of Botany
Adventitious root formation in stem cuttings of Phoebe bournei, an economically and ecologically significant woody species, is a major bottleneck in clonal propagation. To elucidate the impact of spectral quality on early adventitious root development, we characterized the morphological, hormonal, and transcriptomic dynamics of primordium initiation and differentiation under white, red, and blue light. Under red light, cuttings exhibited the earliest and most pronounced formation of white filamentous structures at lenticels, indicative of root primordium initiation, as early as 20 days after cutting, whereas white and blue light treatments showed delayed responses. Paraffin section analysis confirmed the induced origin of …
Building Better Research: Structured Activities To Support Student Projects, Alicia G. Vaandering
Building Better Research: Structured Activities To Support Student Projects, Alicia G. Vaandering
Faculty Learning Day 2026
Students often feel overwhelmed by large research assignments, struggling to break large papers, presentations, or other projects into manageable steps. This session explores practical ways to support the development of students’ research skills through scaffolded in-class activities and assignments. Participants will leave with adaptable ideas for designing and implementing sequenced tasks that reduce overwhelm while building critical research and information literacy skills.
Tips & Tricks For Fostering Online Engagement, Jacqueline Kociubuk, Karen Haskell, Arthur J. Spivack
Tips & Tricks For Fostering Online Engagement, Jacqueline Kociubuk, Karen Haskell, Arthur J. Spivack
Faculty Learning Day 2026
Creating engagement in online classroom spaces often requires new or unique tools, strategies, and practices. Join us as we share some of our student-tested methods for building online engagement in undergraduate and graduate courses across the humanities, social sciences, and natural sciences.
Harmonicthreads: A Formative Evaluation Of A Fabric-Based Digital Musical Instrument Toward Inclusive Music-Making, Ellie Nguyen, Franceli L. Cibrian
Harmonicthreads: A Formative Evaluation Of A Fabric-Based Digital Musical Instrument Toward Inclusive Music-Making, Ellie Nguyen, Franceli L. Cibrian
Engineering Faculty Articles and Research
Background:
Inclusive music-making requires instruments that support varied bodies, abilities, musical backgrounds, and forms of participation. Digital musical instruments provide diverse approaches to sound creation, and fabric-based interfaces offer an alternative interaction modality that may support participation for some users and contexts. Their tactile and deformable properties enable forms of interaction that differ from conventional rigid or screen-based controllers and may offer inclusive possibilities in particular settings.
Objective:
This paper presents HarmonicThreads as a formative interaction-design case of a fabric-based digital musical instrument. The prototype explores how tactile cues, fabric deformation, projected visual feedback, and assisted accompaniment can support low-barrier …
Visual Arts Teachers’ Perception Of Integrating Visual Arts To Help With Student Core Content Achievement, Amanda Munoz
Visual Arts Teachers’ Perception Of Integrating Visual Arts To Help With Student Core Content Achievement, Amanda Munoz
Walden Dissertations and Doctoral Studies
The problem addressed in this study was that local school districts in Texas do not offer a visual arts-integrated curriculum despite the known academic and social-emotional benefits for K–12 students. The purpose of this basic qualitative study was to explore the perceptions of Texas K–12 visual arts teachers regarding arts integration to enhance core content learning. Grounded in Gardner’s multiple intelligences theory, the research questions focused on teachers' perceptions of arts integration and their recommendations for implementation. Data were collected through semistructured interviews with 10 K–12 visual arts teachers in Texas who had at least 1 year of teaching experience. …
Strategies That Black American Female Business Owners Use To Secure Government Contracts, Darrilyn Marie Brittian
Strategies That Black American Female Business Owners Use To Secure Government Contracts, Darrilyn Marie Brittian
Walden Dissertations and Doctoral Studies
Black American female business owners remain underrepresented in government contracting despite the availability of federal, state, and local procurement opportunities. Some Black American female business owners lack effective strategies to secure government contracts, which may limit business growth and profitability. Grounded in innovation and entrepreneurship theory, the purpose of this qualitative pragmatic inquiry was to identify and explore the strategies Black American female entrepreneurs use to secure government contracts. The participants were six Black American female entrepreneurs who had successfully secured government contracts and possessed experience navigating government procurement processes. Data were collected using semistructured interviews and organizational documents. Through …
Strategies General Practitioners Use To Effectively Communicate Patient Cases To Medical Specialists In Saudi Arabia, Alshraefarana Alharthi
Strategies General Practitioners Use To Effectively Communicate Patient Cases To Medical Specialists In Saudi Arabia, Alshraefarana Alharthi
Walden Dissertations and Doctoral Studies
Effective communication between general practitioners (GPs) and medical specialists is essential for reducing healthcare costs and improving continuity of care. Healthcare leaders are concerned that ineffective communication between GPs and specialists may contribute to delays in care, fragmented services, and inefficient use of healthcare resources. Grounded in relational coordination theory, the purpose of this qualitative pragmatic inquiry was to explore the effective communication strategies used by six GPs in Saudi Arabia when communicating patient cases to medical specialists to reduce healthcare costs and improve the quality of patient care. The participants were six GPs in Saudi Arabia. Data were collected …
Androgens Mediate Sexual Dimorphism In Pilarowski-Bjornsson Syndrome., Kimberley Jade Anderson, Eirny Tholl Thorolfsdottir, Ilana M. Nodelman, Sara Tholl Halldorsdottir, Stefania Benonisdottir, Malak A. Alghamdi, Naif A M Almontashiri, Brenda J. Barry, Matthias Begemann, Jacquelyn F. Britton, Sarah Burke, Benjamin Cogne, Ana S A Cohen, Carles De Diego Boguñá, Evan E. Eichler, Elizabeth C. Engle, Jill A. Fahrner, Laurence Faivre, Mélanie Fradin, Nico Fuhrmann, Christine W. Gao, Gunjan Garg, Dagmar Grečmalová, Mina Grippa, Jacqueline R. Harris, Kendra Hoekzema, Tova Hershkovitz, Sydney Hubbard, Katrien Janssens, Julie A. Jurgens, Stanislav Kmoch, Cordula Knopp, Meral Aktas Koptagel, Farah A. Ladha, Pablo Lapunzina, Tobias Lindau, Marije Meuwissen, Andreina Minicucci, Emily Neuhaus, Mathilde Nizon, Lenka Nosková, Kristen Park, Chirag Patel, Rolph Pfundt, Pankaj Prasun, Nils Rahner, Nathaniel H. Robin, Carey Ronspies, Jasmin Roohi, Jill Rosenfeld, Margarita Saenz, Carol J. Saunders, Zornitza Stark, Isabelle Thiffault, Sarah Thull, Danita Velasco, Clara Velmans, Jolijn Verseput, Antonio Vitobello, Tianyun Wang, Karin Weiss, Ingrid M. Wentzensen, Genay Pilarowski, Thor Eysteinsson, Madelyn Gillentine, Kári Stefánsson, Agnar Helgason, Gregory D. Bowman, Hans Tomas Bjornsson
Androgens Mediate Sexual Dimorphism In Pilarowski-Bjornsson Syndrome., Kimberley Jade Anderson, Eirny Tholl Thorolfsdottir, Ilana M. Nodelman, Sara Tholl Halldorsdottir, Stefania Benonisdottir, Malak A. Alghamdi, Naif A M Almontashiri, Brenda J. Barry, Matthias Begemann, Jacquelyn F. Britton, Sarah Burke, Benjamin Cogne, Ana S A Cohen, Carles De Diego Boguñá, Evan E. Eichler, Elizabeth C. Engle, Jill A. Fahrner, Laurence Faivre, Mélanie Fradin, Nico Fuhrmann, Christine W. Gao, Gunjan Garg, Dagmar Grečmalová, Mina Grippa, Jacqueline R. Harris, Kendra Hoekzema, Tova Hershkovitz, Sydney Hubbard, Katrien Janssens, Julie A. Jurgens, Stanislav Kmoch, Cordula Knopp, Meral Aktas Koptagel, Farah A. Ladha, Pablo Lapunzina, Tobias Lindau, Marije Meuwissen, Andreina Minicucci, Emily Neuhaus, Mathilde Nizon, Lenka Nosková, Kristen Park, Chirag Patel, Rolph Pfundt, Pankaj Prasun, Nils Rahner, Nathaniel H. Robin, Carey Ronspies, Jasmin Roohi, Jill Rosenfeld, Margarita Saenz, Carol J. Saunders, Zornitza Stark, Isabelle Thiffault, Sarah Thull, Danita Velasco, Clara Velmans, Jolijn Verseput, Antonio Vitobello, Tianyun Wang, Karin Weiss, Ingrid M. Wentzensen, Genay Pilarowski, Thor Eysteinsson, Madelyn Gillentine, Kári Stefánsson, Agnar Helgason, Gregory D. Bowman, Hans Tomas Bjornsson
Manuscripts, Articles, Book Chapters and Other Papers
Sex-specific penetrance in autosomal-dominant Mendelian conditions is largely understudied. The neurodevelopmental disorder Pilarowski-Bjornsson syndrome (PILBOS) was initially described in females. Here, we describe the clinical and genetic characteristics of the largest PILBOS cohort to date, showing that both sexes can exhibit PILBOS features, although males are overrepresented. A mouse model carrying a human-derived Chd1 missense variant (Chd1R616Q/+) displays female-restricted phenotypes, including growth deficiency, anxiety, and hypotonia. Orchiectomy unmasks a growth-deficiency phenotype in male Chd1R616Q/+ mice, while testosterone rescues the phenotype in females, implicating androgens in phenotype modulation. In the gnomAD and UK Biobank databases, rare missense variants …