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2026

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The Shorthorn: September 10, 1986 Sep 2026

The Shorthorn: September 10, 1986

The Shorthorn Newspaper Collection: 1980s

No abstract provided.


The Shorthorn: September 9, 1986 Sep 2026

The Shorthorn: September 9, 1986

The Shorthorn Newspaper Collection: 1980s

No abstract provided.


The Shorthorn: September 5, 1986 Sep 2026

The Shorthorn: September 5, 1986

The Shorthorn Newspaper Collection: 1980s

No abstract provided.


The Shorthorn: September 3, 1986 Sep 2026

The Shorthorn: September 3, 1986

The Shorthorn Newspaper Collection: 1980s

No abstract provided.


Noda News September 2026 Sep 2026

Noda News September 2026

New Orleans Dental Association News

New Orleans Dental Association (NODA) News includes regular columns with regional news impacting the New Orleans membership including: columns from the President and Executive Director, feature articles relating to the field of dentistry, association events and upcoming activities, component news, continuing education opportunities, and classifieds.


Identification Of Current Ai Usage In The Fields Of Exercise-Related Professions And The Requirement Of Ai Experience As A Hiring Criterion: A Preliminary Study, Michelle Stehman, Matthew Hankinson Sep 2026

Identification Of Current Ai Usage In The Fields Of Exercise-Related Professions And The Requirement Of Ai Experience As A Hiring Criterion: A Preliminary Study, Michelle Stehman, Matthew Hankinson

Educational Practices in Kinesiology

Artificial intelligence (AI) is increasing within exercise-related professions, raising the question of whether college curricula for these professions should include AI education. This study aimed to evaluate current AI usage and to discover the priority of AI skills for hiring managers among exercise-related professionals. Section one of the questionnaire included questions about current use of AI within exercise-related professions (N = 65), and section two was specific to hiring managers and their position on AI skills as a hiring requirement (n = 32 completed this section). The main outcome of this study was that 32% of exercise-related professionals …


Depoarch: Physics-To-Architecture Modeling And Mitigation Of Thin-Film Deposition Non-Idealities In Advanced Multicore Processors, Gopi K. Tummala Sep 2026

Depoarch: Physics-To-Architecture Modeling And Mitigation Of Thin-Film Deposition Non-Idealities In Advanced Multicore Processors, Gopi K. Tummala

Defensive Publications Series

As semiconductor fabrication scales toward atomic dimensions in sub-3 nm gate-all-around (GAAFET) and complementaryFET (CFET) architectures, physical non-idealities in thin-film deposition increasingly govern chip performance, energy efficiency, and long-term reliability. Traditional computer architecture research has long abstracted the underlying silicon fabric as a set of deterministic, planar geometries characterized by nominal resistance-capacitance (RC) parasitics, treating process variation strictly through empirical statistical abstractions such as Random Dopant Fluctuations (RDF) and sub-wavelength Line Edge Roughness (LER). In reality, the physical mechanisms of Chemical Vapor Deposition (CVD) and Physical Vapor Deposition (PVD) impart severe, deterministic spatial gradients and microscopic structural flaws that break …


Q-Razor: A Variation-Tolerant, Speculative Classical Control Microarchitecture For Cryogenic Fault-Tolerant Quantum Error Correction, Gopi K. Tummala Sep 2026

Q-Razor: A Variation-Tolerant, Speculative Classical Control Microarchitecture For Cryogenic Fault-Tolerant Quantum Error Correction, Gopi K. Tummala

Defensive Publications Series

Fault-tolerant quantum computing (FTQC) requires classical control processors to execute quantum error correction (QEC) syndrome decoding, Pauli frame updates, and pulse orchestration within microsecond-scale physical qubit coherence windows. To resolve the catastrophic thermal and wiring bottlenecks of routing tens of thousands of microwave coaxial lines from room temperature to a dilution refrigerator, modern architectures place classical control and decoding processors at the 4 Kelvin cryogenic stage. However, 4 K cryogenic CMOS introduces an acute architectural tension: severe carrier freeze-out, amplified random discrete dopant fluctuations (RDF), and localized dynamic thermal hot spots induce up to 3× timing delay variability, while the …


Chesscore: A Reconfigurable Domain-Specific Architecture For Accelerating Adversarial Game-Tree Search And Heuristic Learning, Gopi K. Tummala Sep 2026

Chesscore: A Reconfigurable Domain-Specific Architecture For Accelerating Adversarial Game-Tree Search And Heuristic Learning, Gopi K. Tummala

Defensive Publications Series

Adversarial game-tree search—exemplified by classical zerosum games of perfect information such as Tic-Tac-Toe and Chess—represents a foundational benchmark for artificial intelligence and combinatorial optimization. However, executing recursive minimax algorithms with α-β pruning on generalpurpose von Neumann microprocessors suffers from crippling architectural bottlenecks: branch misprediction rates exceeding 30% during search cutoffs, serialized legal move generation, deep recursion stack thrashing, and high-latency memory stalls during transposition table lookups. This paper presents ChessCore, a reconfigurable domainspecific hardware architecture designed for high-throughput adversarial tree search and heuristic learning. Grounded in an architectural lineage originally prototyped on a resourceconstrained Xilinx Spartan-II FPGA (XC2S50 TQ144) using …


Hexatile: A Scalable Heterogeneous Honeycomb-Tiled Manycore Architecture With Decoupled Multi-Plane Interconnects And Adaptive Hardwalls, Gopi K. Tummala Sep 2026

Hexatile: A Scalable Heterogeneous Honeycomb-Tiled Manycore Architecture With Decoupled Multi-Plane Interconnects And Adaptive Hardwalls, Gopi K. Tummala

Defensive Publications Series

Tiled manycore architectures established a modular paradigm that conquered the global wire-delay wall by decomposing monolithic processors into replicated, network-connected compute elements. Early academic prototypes, such as the MIT Raw microprocessor, and commercial implementations, including Tilera TILE64, TILEPro64, and Tile-Gx 100, proved the viability of pipelined scalar operand networks and 2D mesh on-chip interconnects. However, scaling tiled architectures beyond 100 tiles toward the multi-thousand-tile horizon encounters four crippling bottlenecks: (1) the Cartesian Diameter and Hop-Count Wall in 2D Manhattan meshes, which incurs severe routing latency and packet contention; (2) the Technology Utilization and Dark Silicon Wall, where uniform homogeneous tiles …


Low-Energy Conservation Cores With On-Chip Dynamic Power Management For Advanced Computations, Gopi K. Tummala Sep 2026

Low-Energy Conservation Cores With On-Chip Dynamic Power Management For Advanced Computations, Gopi K. Tummala

Defensive Publications Series

Transistor density continues to scale with advances in semiconductor manufacturing, but limits on threshold voltage scaling have brought classical Dennard power scaling to a permanent halt. The resulting technology-imposed “utilization wall” severely restricts the fraction of silicon that can be continuously operated at maximum performance, giving rise to the dark silicon phenomenon. Because reductions in per-operation energy translate directly into increased parallel throughput under fixed thermal envelopes, specialized and heterogeneous architectures have emerged as an imperative. However, conventional parallel accelerators fail when applied to irregular integer codes characterized by tight critical paths, branch-heavy control flow, and poor memory locality. This …


Compiler-Orchestrated Fine-Grained Power Gating And Asymmetric Power Islands For Tiled Spatial Microprocessors, Gopi K. Tummala Sep 2026

Compiler-Orchestrated Fine-Grained Power Gating And Asymmetric Power Islands For Tiled Spatial Microprocessors, Gopi K. Tummala

Defensive Publications Series

As semiconductor technology scales deep into nanoscale dimensions (sub-65 nm), subthreshold leakage current threatens the viability of tiled spatial microprocessors. While spatial architectures—exemplified by the MIT/UCSD RAW processor—elegantly eliminate global wire delays and expose on-chip functional units, interconnects, and pins directly to software, their massive replication of execution resources results in substantial static power waste when application workloads exhibit spatial or temporal underutilization. Traditional reactive dynamic power management (DPM) schemes, such as OS-directed ACPI states or hardware activity timers, fail in spatial architectures due to unpredictable wake-up transition penalties, loss of cycle-level synchronization across scalar operand networks (SONs), and inability …


Techno-Economic Assessment Of Residential Prosumer Systems Using Real Household Consumption Data: A Case Study From Bosnia And Herzegovina, Alen Selmanović, Mehrija Hasičić Sep 2026

Techno-Economic Assessment Of Residential Prosumer Systems Using Real Household Consumption Data: A Case Study From Bosnia And Herzegovina, Alen Selmanović, Mehrija Hasičić

Communications of the IIMA

This paper evaluates the technical, economic, and environmental feasibility of residential prosumer implementation in Sarajevo, Bosnia and Herzegovina, through the integration of photovoltaic (PV) generation and battery energy storage. A simulation‑based assessment was performed in HOMER Pro using a measured 12‑month household load profile with an average daily consumption of 11.25 kWh and a peak demand of 2.85 kW. Six system configurations were investigated, consisting of 3 kW, 4 kW, and 5 kW PV installations, each analyzed with and without a 5.04 kWh lithium‑ion battery, over a 25‑year project lifetime under a zero‑credit export scheme. Among the analyzed configurations, the …


From Dissertation To Deployment: A Unified Software Platform Operationalizing Clinical-Prediction And Sequential-Security Ai For Healthcare, Olsi Shehu, Damiana Teliti, Jasmin Kevrić, Bekir Karlik Sep 2026

From Dissertation To Deployment: A Unified Software Platform Operationalizing Clinical-Prediction And Sequential-Security Ai For Healthcare, Olsi Shehu, Damiana Teliti, Jasmin Kevrić, Bekir Karlik

Communications of the IIMA

Advances in machine learning for healthcare are abundant, yet most validated models remain confined to research notebooks and never reach secure, usable clinical software. This paper addresses that deployment gap by presenting a unified, security-hardened software platform that operationalizes two complementary streams of doctoral research inside a single, role-based hospital information system. The first stream contributes a clinical-prediction capability: an ultra-hybrid ensemble that couples a quantum-inspired feature transformation, particle-swarm feature selection, and calibrated soft voting for cancer-outcome prediction (96.41% accuracy, AUC-ROC 0.983 on TCGA-BRCA), survival stratification, multi-cancer generalization, and pharmacogenomic drug-response classification (89.31% mean accuracy across 25 compounds). The second …


Ai-Based Displacement Forecasting For Real-Time Landslide Risk Assessment In The Danube Region, Amina Čehaja, Asja Muharemović, Jasmin Kevrić, Dejan Jokić, Mirza Ponjavić Sep 2026

Ai-Based Displacement Forecasting For Real-Time Landslide Risk Assessment In The Danube Region, Amina Čehaja, Asja Muharemović, Jasmin Kevrić, Dejan Jokić, Mirza Ponjavić

Communications of the IIMA

This paper presents a dual-layered AI framework for real-time landslide risk assessment developed under the GeoNetSee project within the Interreg Danube Region Programme. The first layer employs a fuzzy logic model, inspired by the Slovenian MASPREM system, which integrates Landslide Susceptibility Maps (LSS) with high-resolution precipitation forecasts from the Open-Meteo API to generate a Predicted Landslide Hazard (PLSH) score on a 0–5 scale, updated every 6–12 hours. The second layer focuses on real-time ground displacement detection by fusing low-cost dual-frequency GNSS receivers with MEMS accelerometers and applying machine learning regression algorithms, including Support Vector Regression (SVR), Long Short-Term Memory (LSTM), …


Comparative Analysis Of Takagi-Sugeno And Mamdani Fuzzy Inference Architectures With Anfis-Based Automated Rule Generation For Eeg-Based Cognitive State Monitoring, Amina Radončić, Mehrija Hasičić, Jasmin Kevrić Sep 2026

Comparative Analysis Of Takagi-Sugeno And Mamdani Fuzzy Inference Architectures With Anfis-Based Automated Rule Generation For Eeg-Based Cognitive State Monitoring, Amina Radončić, Mehrija Hasičić, Jasmin Kevrić

Communications of the IIMA

Fuzzy inference systems have demonstrated considerable promise for EEG-based cognitive state monitoring in neurodegenerative conditions. However, two design decisions significantly influence system performance and clinical applicability: the choice of inference architecture (Takagi-Sugeno vs Mamdani) and the method of rule and membership function generation (manual expert-driven vs data-driven automated). This paper presents a comparative analysis of both dimensions in the context of an EEG-based Alzheimer’s disease monitoring system operating on the ds004504 OpenNeuro dataset (88 subjects: 36 AD, 23 FTD, 29 HC). A Takagi-Sugeno system, implemented as a hybrid FSM-Fuzzy architecture, is compared against a Mamdani equivalent across four axes: inference …


Efficacy Of A Mouthwash Containing Standardized Centella Asiatica Extract (Eca 233) In Patients With Gingivitis: A Randomized Double-Blind Placebo-Controlled Trial, Alisa Awapark, Wanchai Chongcharoen, Mayuree H. Tantisira, Nattapon Rotpenpian Sep 2026

Efficacy Of A Mouthwash Containing Standardized Centella Asiatica Extract (Eca 233) In Patients With Gingivitis: A Randomized Double-Blind Placebo-Controlled Trial, Alisa Awapark, Wanchai Chongcharoen, Mayuree H. Tantisira, Nattapon Rotpenpian

The Thai Journal of Pharmaceutical Sciences

Background: Gingivitis is the earliest and most reversible stage of periodontal disease, characterized by inflammation of the gingiva caused by the accumulation of plaque. In addition to removing plaque, mouthwash containing antiseptic or anti-inflammatory could be used as an adjunct therapy.
Objectives: The objective of this study is to evaluate the efficacy of a 0.10% standardized Centella asiatica extract (ECa 233) mouthwash compared to 0.12% chlorhexidine and placebo mouthwashes in individuals with gingivitis.
Materials and Methods: A randomized, double-blind, placebo-controlled clinical trial was conducted in 75 patients assigned equally to ECa 233, chlorhexidine, or placebo groups. Participants used the assigned …


Surgical And Transcatheter Pulmonary Valve Replacement In Patients With Congenital Heart Disease, Who Have A History Of Right Ventricular Outflow Tract Remodeling, Indonesia: A Model-Based Economic Evaluation, Andi Nurul Annisa, Puree Anantachoti, Radityo Prakoso, Dafsah A. Juzar, Osot Nerapusee Sep 2026

Surgical And Transcatheter Pulmonary Valve Replacement In Patients With Congenital Heart Disease, Who Have A History Of Right Ventricular Outflow Tract Remodeling, Indonesia: A Model-Based Economic Evaluation, Andi Nurul Annisa, Puree Anantachoti, Radityo Prakoso, Dafsah A. Juzar, Osot Nerapusee

The Thai Journal of Pharmaceutical Sciences

Background: Patients with congenital heart disease who have previously undergone right ventricular outflow tract (RVOT) surgery frequently require repeat valve replacement later in life. While transcatheter pulmonary valve replacement (TPVR) offers less invasive reintervention compared with surgery, its high device cost raises concerns about affordability under Indonesia’s National Health Insurance Program (Jaminan Kesehatan Nasional).
Objectives: To compare the cost-effectiveness of surgical pulmonary valve replacement (SPVR) versus TPVR in post-RVOT surgery patients, and to estimate the TPVR price threshold for cost-effectiveness from a societal perspective.
Methods: A Markov model simulated a hypothetical cohort of 15-year-old patients with prior RVOT surgery over …


Virtual Scroll Wheel Input Device With Adaptive Touch Sensing And Modular Haptic Feedback, Madhav Kavuru Sep 2026

Virtual Scroll Wheel Input Device With Adaptive Touch Sensing And Modular Haptic Feedback, Madhav Kavuru

Defensive Publications Series

This disclosure describes a curved-surface capacitive input device that reproduces the tactile behavior of a mechanical scroll wheel within a total assembly stack height of approximately 9.5 mm, making scroll-wheel functionality practical in ultraportable laptop keyboards for the first time. A mutual-capacitance touch strip is formed along the arc of a protruding disk segment rather than on a flat surface, giving the finger the same curved reference geometry as a physical wheel. A linear resonant actuator (LRA) of the type used in smartwatches is bonded to part of the chord of that disk segment and driven with pulse-width-modulated waveform profiles …


Agents, Inc., Kevin Werbach Sep 2026

Agents, Inc., Kevin Werbach

Villanova Law Review (1956 - )

No abstract provided.


Ending Randomized Outcomes: Using Consumer Protection Laws To Regulate Video Game Loot Boxes And Monetization Practices That Target Children, Dennis Reilly Sep 2026

Ending Randomized Outcomes: Using Consumer Protection Laws To Regulate Video Game Loot Boxes And Monetization Practices That Target Children, Dennis Reilly

Villanova Law Review (1956 - )

No abstract provided.


Medetomidine As A Fentanyl Adulterant: Pharmacology, Detection, Clinical Presentation, And Management, Kory S. London, Phil Durney, Brendan Hart, Ashish Thakrar, Dennis Goodstein, Alex J. Krotulski, Daniel Teixeira Da Silva, Joseph D’Orazio, Lara Weinstein, Jeanmarie Perrone, Michael J. Lynch Sep 2026

Medetomidine As A Fentanyl Adulterant: Pharmacology, Detection, Clinical Presentation, And Management, Kory S. London, Phil Durney, Brendan Hart, Ashish Thakrar, Dennis Goodstein, Alex J. Krotulski, Daniel Teixeira Da Silva, Joseph D’Orazio, Lara Weinstein, Jeanmarie Perrone, Michael J. Lynch

Division of Internal Medicine Faculty Papers & Presentations

Purpose of Review Medetomidine is a veterinary α2-adrenergic agonist that has been an adulterant of illicitly manufactured opioids since 2022. We review its pharmacology, detection, intoxication, withdrawal, and management, and assess why severe withdrawal has emerged in some regions but not others. Recent Findings Medetomidine has spread through North American drug markets yet evades most toxicology testing. Roughly two hundred times more potent than xylazine, with greater α2 selectivity and imidazoline-1 activity, it causes intoxication resembling other α2 agonists: sedation and bradycardia. The dominant clinical problem is withdrawal: autonomic dysregulation, intractable vomiting, and encephalopathy frequently requiring intensive care. Treatment requires …


Neither Disembodied Nor Triumphalist: The Voice Of Christian Hope, Gayle E. Doornbos Sep 2026

Neither Disembodied Nor Triumphalist: The Voice Of Christian Hope, Gayle E. Doornbos

Faculty Work Comprehensive List

"Hope in the Psalms is a real, honest declaration, amid the awful realities of life, that we cannot manufacture or optimize our way out of our pain. Rather, in our pain we turn to the only one who can restore us and who has promised us a day when pain, death, and sorrow will be no more."

Posting about words for the suffering in In All Things, an online hub that offers insight into maintaining and faithful and orthodox Reformed Christian worldview while fearlessly engaging in every aspect of contemporary life – until all is made new.

Neither Disembodied nor …


Effects Of Social Comparison Instructions On Affect, Motivation For Healthy Behavior, And Health Behavior Selections: Guidance To Identify Or Contrast, Raj Harsora Sep 2026

Effects Of Social Comparison Instructions On Affect, Motivation For Healthy Behavior, And Health Behavior Selections: Guidance To Identify Or Contrast, Raj Harsora

Theses and Dissertations

Engaging in healthy behaviors early in life is crucial for preventing noncommunicable diseases such as type 2 diabetes, cancer, and heart disease. College is an optimal period to establish these habits, yet students often engage in poor dietary and physical activity practices; thus, identifying effective health behavior change techniques for this population is essential. Social comparisons are known to influence health behaviors, yet no research has tested comparison instructions as a behavior change technique, particularly identification versus contrast with upward and downward targets. Using a preregistered protocol (https://osf.io/z29en), we tested whether guiding college students (N=664) to identify with or contrast …


Problematic Technology Use And Quality Of Life In College Students With Varying Levels Of Schizotypy, Joseph P. Skinner Sep 2026

Problematic Technology Use And Quality Of Life In College Students With Varying Levels Of Schizotypy, Joseph P. Skinner

Theses and Dissertations

Problematic Technology Use (PTU) has emerged as a growing concern with technology’s continual integration into daily living. Individuals higher in schizotypy may be particularly vulnerable to the negative consequences of digital environments. The present study cross-sectionally examined associations among schizotypy, PTU, and quality of life (QOL) in 533 college students using structural equation modeling. Consistent with hypotheses, greater total schizotypy was associated with higher PTU and lower QOL. Additionally, positive, negative, and disorganized schizotypy all uniquely predicted poor QOL with the negative domain demonstrating the strongest standardized association. Contrary to hypotheses, PTU did not significantly moderate the relation between total …


Struggling Readers Collaborate On Reading Interventions For Fifteen Minutes A Day, Jordan Dobzanski Sep 2026

Struggling Readers Collaborate On Reading Interventions For Fifteen Minutes A Day, Jordan Dobzanski

Theses and Dissertations

This thesis examines what happens when struggling readers collaborate on reading intervention practices for fifteen minutes a day. Relevant theories that guided this research included Bandura’s Social Learning Theory, Vygotsky’s Social Constructivist Theory, and Lankshear and Knobel’s New Literacies Theory. Throughout the six-week study, four third-grade students identified as below grade level participated in a collaborative reading intervention that focused on vocabulary development, fiction and informational text comprehension, student-led discussions, digital literacy activities, and reflective journaling. Students worked together in structured literature circles while engaging in literacy activities connected to their classroom curriculum. Data were analyzed through triangulation in order …


Business Process Redesign Through Hybrid Automation: A Case Study Of A Remittance Service Provider, Mary Rose P. Andrada, Leilani De Guzman Sep 2026

Business Process Redesign Through Hybrid Automation: A Case Study Of A Remittance Service Provider, Mary Rose P. Andrada, Leilani De Guzman

Journal of Management for Global Sustainability

Remittance service providers operate in highly regulated environments that demand strict compliance with anti-money laundering (AML) and know-your-customer (KYC) requirements. Despite advances in financial technology, many remittance organizations still rely on traditional processing systems marked by manual data entry, fragmented workflows, repetitive verification procedures, and multiple operational touchpoints. These inefficiencies lead to processing delays, higher operational costs, heavier employee workloads, and lower customer satisfaction. This study examines the potential of hybrid automation as a process redesign strategy within business process management (BPM) to address operational challenges in remittance processing. Drawing on existing literature, the study explores how integrating robotic process …


Chimes: September 8, 2026, Calvin University Sep 2026

Chimes: September 8, 2026, Calvin University

Chimes

Chaos Night 2026: BHT takes home second consecutive win by Brantley Tiede

Printing budget eliminated for students by Ellery Johnson

Synod 2026 accepts Calvin's progress on confessional alignment, pride flags spark debate by Ian Tjoelker

Calvin 101: How to enjoy your Calvin experience by Evangeline Anga

"A mindset of service": the legacy of StreetFest by McKenna Wilkinson

Mental Health: my journey by Tanya Peter


Ai-Based Community Pharmacy Antibiotic Use Misuse Analysis: A Community-Based Study, Yasameen Riyadh Saeed Al-Azzawi Sep 2026

Ai-Based Community Pharmacy Antibiotic Use Misuse Analysis: A Community-Based Study, Yasameen Riyadh Saeed Al-Azzawi

Muthanna Medical Journal

Background: The misuse of antibiotics in the community is a significant health issue of concern since it directly leads to antimicrobial resistance, treatment failure, and health care burden. Aim: determine the trend of antibiotic misuse in community pharmacies and to use analytical models based on artificial intelligence. Methods: The current research was carried out in a sample of the community pharmacies in the city of Hilla, Babylon, Iraq, between November 2025 and February 2026. There were 200 encounters of antibiotics dispensing. The structured recording form was used as the data collection instrument to record the sociodemographic data, presenting …


Blinatumomab Care Delivery For Pediatric B-Cell Acute Lymphoblastic Leukemia, Daniel Zheng, Katelyn Oranges, Subhash Ramakrishnan, Lingyun Ji, Melissa Beauchemin, Sarah Alexander, Allison Leahy, Kira Bona, Emi Caywood, Sharon Castellino, Sumit Gupta, Douglas Hawkins, Olga Militano, Kathleen Montgomery, Haley Newman, Rachel Rau, Susan Rheingold, Joanna Robles, Michael Roth, David Teachey, Sarah Vargas, Sue Zupanec, Susan Parsons Sep 2026

Blinatumomab Care Delivery For Pediatric B-Cell Acute Lymphoblastic Leukemia, Daniel Zheng, Katelyn Oranges, Subhash Ramakrishnan, Lingyun Ji, Melissa Beauchemin, Sarah Alexander, Allison Leahy, Kira Bona, Emi Caywood, Sharon Castellino, Sumit Gupta, Douglas Hawkins, Olga Militano, Kathleen Montgomery, Haley Newman, Rachel Rau, Susan Rheingold, Joanna Robles, Michael Roth, David Teachey, Sarah Vargas, Sue Zupanec, Susan Parsons

Department of Pediatrics Faculty Papers

IMPORTANCE: Blinatumomab, a novel immunotherapy administered as a 28-day continuous infusion, has fundamentally shifted the treatment paradigm for pediatric B-cell acute lymphoblastic leukemia (B-ALL) and is now considered a component of standard therapy for the most common childhood cancer. However, the care delivery challenges in transitioning from an experimental agent on a clinical trial to widespread clinical implementation are unknown.

OBJECTIVE: To characterize the clinical landscape of pediatric blinatumomab care-delivery practice and challenges in the US from the perspective of treating centers.

DESIGN, SETTING, AND PARTICIPANTS: This survey study was conducted from February to March 2025 among US member institutions …