Digital Commons Network^™

Fitness Cost And Biofilm Formation In Fosfomycin-Resistant Clinical Escherichia Coli And Klebsiella Pneumoniae Isolates, Mustafa Ökeer, Sabi̇re Şöhret Aydemi̇r, Bayri Eraç

Turkish Journal of Medical Sciences

Background/aim: Fosfomycin has regained importance owing to its unique mechanism of action and effectiveness against extended-spectrum β-lactamase-producing Gram-negative bacteria. This study aimed to evaluate the biological fitness cost associated with fosfomycin resistance and its impact on biofilm formation in clinical Enterobacteriaceae isolates.

Materials and methods: A total of 78 Escherichia coli and 34 Klebsiella pneumoniae strains isolated from urine samples at Ege University Hospital were analyzed. Fosfomycin minimum inhibitory concentrations (MICs) were determined using the reference agar dilution method. Resistance was induced by exposing two K. pneumoniae strains with a fosfomycin MIC of 4 μg/mL and two E. coli strains …

Public Speaking 2026, Lynn Brewer

UNH Cooperative Extension

No abstract provided.

2026 Sullivan County 4-H Presents, Lynn Brewer

UNH Cooperative Extension

No abstract provided.

Demonstration 2026, Lynn Brewer

UNH Cooperative Extension

No abstract provided.

Action 2026, Lynn Brewer

UNH Cooperative Extension

No abstract provided.

Sc 4-H Presents Information Packet, Lynn Brewer

UNH Cooperative Extension

No abstract provided.

Sting Activation Induces Cytotoxic And Immune Responses In Meningiomas Via Inflammatory Cell Death Pathways, Mark W Youngblood, Alexander H Stegh, Et Al.

2020-Current year OA Pubs

Meningiomas are common tumors of the central nervous system that are typically treated with surgery or radiation, but lack established systemic therapies. Activation of the stimulator of interferon genes pathway with an agonist such as 8803 can trigger anti-tumor immune responses. Using integrated molecular approaches, here we show that this pathway is targetable in both neoplastic and immune populations within the meningioma microenvironment. Meningioma tumor cells exhibit promoter hypomethylation and increased chromatin accessibility of the STING genomic locus, associated with robust expression of this gene. Treatment of diverse patient meningiomas ex vivo with 8803 induces direct tumor cytotoxicity through inflammatory …

Albumin-Binding Domains In Therapeutic Protein Engineering: A Structural And Computational Perspective On Rational Design, Matthew Argyle, Dallin M. Chipman, Anna Claire Woolley, Bradley C. Bundy, Dennis Della Corte

Faculty Publications

Therapeutic proteins face a critical pharmacokinetic challenge: rapid clearance from circulation limits their clinical efficacy. Albumin-binding domains (ABDs) offer an elegant solution by enabling therapeutic proteins to “hitchhike” on serum albumin’s favorable 19-day half-life through FcRn-mediated recycling. Clinical validation through approved therapeutics like ozoralizumab demonstrates the success of this approach, with preclinical studies showing fusion to an ABD extended half-life to 18 days. This review provides an analysis of ABD-fusion protein design, integrating structural biology, computational prediction, and rational engineering principles. We catalog the major classes of albumin-binding modalities, including bacterial three-helix bundle domains, engineered peptides, antibody-derived binders, and alternative …

Tell Me Again Who Are You?, Heather Sellers

Creative Nonfiction Magazine

No abstract provided.

Notes On The Space We Take, Bonnie J. Rough

Creative Nonfiction Magazine

No abstract provided.

Wild Flavor, Karl Taro Greenfield

Creative Nonfiction Magazine

No abstract provided.

North Pole, South Pole, The Sea Of Carcinoma, Dev Hathaway

Creative Nonfiction Magazine

No abstract provided.

Thirteen More Ways Of Looking At A Blackbird, Dorie Bargmann

Creative Nonfiction Magazine

No abstract provided.

Job No. 51 - Executive Director And Job No. 52 - Psychic Medium, Oliverdavies .Blogspot.Com

Creative Nonfiction Magazine

No abstract provided.

The Truth About Cops And Dogs, Rebecca Skloot

Creative Nonfiction Magazine

No abstract provided.

Consumption, Sunshine O'Donnell

Creative Nonfiction Magazine

No abstract provided.

'Mbriago, Louise Desalvo

Creative Nonfiction Magazine

No abstract provided.

The Cipher In Room 214: Who Was Mary Anderson Why Did She Die?, Carol Smith

Creative Nonfiction Magazine

No abstract provided.

Luke And Leonardo

Creative Nonfiction Magazine

No abstract provided.

Netting The Future, Donna Seaman

Creative Nonfiction Magazine

No abstract provided.

The Library As Storyplace, Rebecca T. Miller

Creative Nonfiction Magazine

No abstract provided.

Mama, Che Cosa Vuoi Che Faccio?, James Vescovi

Creative Nonfiction Magazine

No abstract provided.

Dagos In Mayberry, Peter Selgin

Creative Nonfiction Magazine

No abstract provided.

'Mbriago, Louise Desalvo

Creative Nonfiction Magazine

No abstract provided.

Temporal Dynamics Of Irrigation Characteristics In South Carolina, Selvalakshmi Selvaraj, Jose O. Payero, Dana B. Turner

Journal of South Carolina Water Resources

Irrigation plays a vital role in stabilizing crop production under climatic variability in the southeastern United States. However, limited long-term empirical evidence exists on how irrigation practices, water sources, and energy demands have evolved in South Carolina. The aim of this study was to examine temporal changes in irrigation characteristics in South Carolina. The analysis utilized two decades (2003–2023) of data from the United States Department of Agriculture – National Agricultural Statistics Service, Irrigation and Water Management Surveys. Results showed a 65% increase in the number of irrigated farms and 260% expansion in irrigated acreage over the twenty-year period. Groundwater …

Mountaineer, Craig Bernier

Creative Nonfiction Magazine

No abstract provided.

Without A Map, Meredith Hall

Creative Nonfiction Magazine

No abstract provided.

From “A Writer’S Life”, Gay Talese

Creative Nonfiction Magazine

No abstract provided.

Style-Preserved Inference Flow (Spif): Real-Time Style-Locked Image Generation Through Model Pruning And Latent Space Optimization, Douglass W. Sharp

Defensive Publications Series

This publication discloses Style-Preserved Inference Flow (SPIF), a system for real-time style-locked image generation that maintains consistent artistic style across frames at interactive rates. The core innovation is structural model pruning guided by style-consistency metrics rather than general image quality, producing compact single-purpose models that generate images in a specific artistic style at 60+ frames per second. Additional disclosed techniques include latent-space frame coherence (bootstrapping sequential frames from previous latent states, analogous to dirty-rectangle optimization in game rendering), composable latent object descriptors for real-time scene manipulation, and voice-driven continuous generation loops. Working prototypes demonstrate 3.35 FPS full-pipeline generation at 1024×1024 …

Tiny But Moral: How "The Adventures Of Little Tiny And The White Mouse" Portrays Children’S Moral And Social Responsibilities In The Civil War Era, Abigail Hagopian

CAFE Symposium 2026

Estimated to have been published between 1860 and 1866, The Adventures of Little Tiny and the White Mouse was one of many works for children published by Thomas W. Strong in New York during the American Civil War. The eight-page picture book examines morality and consequences through the misfortunate adventures of a young, yet moral, abnormally small boy named Little Tiny. The youngest of a Broom Maker’s three sons, Tiny’s jealous older brothers sell him to a circus, where he performs alongside a myriad of animals. Missing his father, the animals jump through a series of hoops to help Tiny …