Tumor Implantation Site Of Syngeneic Oral Cancer Models Differentially Induces Site-Dependent Local And Systemic Immunosuppression, Andrea H Molina, Gemalene M Sunga, Shawn Nguyen, Neeraja Dharmaraj, Ratna Veeramachaneni, Roberto Rangel, Jeffrey N Myers, Jeffrey D Hartgerink, Andrew G Sikora, Simon Young

Faculty, Staff and Student Publications

Background/objectives: Preclinical studies of head and neck squamous cell carcinoma (HNSCC) commonly use subcutaneous heterotopic (flank) tumor models for simplicity; however, orthotopic models may better reflect the native tumor environment. Direct comparisons of the tumor immune microenvironments (TIME) and tumor-draining lymph nodes (tdLNs) between these models remain limited. Better understanding of site-specific immune differences could improve model selection and interpretation of translational HNSCC studies.

Methods: ROC1 tumors were established in murine heterotopic and orthotopic sites, followed by assessment of tumor growth kinetics, survival, and the tumor microenvironment. Immune composition of tumors, blood, tdLNs, and spleen was evaluated at three tumor …

Devuélveme A Mi Walkman: A Deep Dive Into Chicano Culture, New Wave And Punk During The 80s In Los Angeles, Michellas Baca

UNLV Theses, Dissertations, Professional Papers, and Capstones

Throughout this creative thesis/magazine, I explore and capture the essence of Chicano culture in the 80s and the role music played, in its simplest form. This project is heavily inspired by my dad and our shared love for music. Growing up in the 80's, pop culture was all around me, constantly; so much so, I never thought twice about it. As I got older, he told me more stories about growing up in L.A. He told me about breakdancing on Venice Beach and riding his bike under the L.A. River bridge. He would tell me stories about parties and how …

Evaluation Of Two Bioaerosol Sampling And Analysis Methods For The Collection Of Airborne Bacteria And Viruses, Elizabeth Detrick

UNLV Theses, Dissertations, Professional Papers, and Capstones

Bioaerosols, defined as airborne particles of biological origin, include bacteria, fungi, viruses, and their byproducts. They are ubiquitous in both indoor and outdoor environments and can cause respiratory infections, allergic reactions, and toxin-mediated illnesses. Air sampling plays a vital role in bioaerosol monitoring by enabling the collection and analysis of airborne microorganisms to assess exposure risk and inform mitigation strategies. The objective of this study was to determine the relative collection efficiency of two air samplers, the MD8 Airscan, a filtration sampling method, and the SKC BioSampler, an impingement sampling method. Aerosolization tests were conducted in a controlled test chamber …

Thermal Physiological Ecology Of The Relict Leopard Frog At Hot And Cold Springs, Robert P. Pelletier Iii

UNLV Theses, Dissertations, Professional Papers, and Capstones

The relict leopard frog (Rana onca) once ranged across drainages in southern Nevada, northwestern Arizona, and southwestern Utah. Following a decline, the species only persisted in a few geothermally influenced hot springs, which led to the perspective that hot springs were high-quality habitat. Rana onca has been under intensive, multiagency management and the species has been translocated to establish additional populations, including at cold-water sites. Three research studies are presented into the thermal physiological ecology of R. onca with the aim of informing conservation strategy. The research was focused at a thermally influenced hot spring and a cold-water spring to …

Potential Innate And Adaptive Roles Played By Γδ T Cells In A Bacterial Immunization Model, Lee Anne Talbot

Seton Hall University Dissertations and Theses (ETDs)

Francisella tularensis is a highly infectious intracellular bacterium and the causative agent of tularemia, with pulmonary infection resulting in severe disease and high mortality if untreated. While protective immunity to F. tularensis has been largely attributed to CD4⁺ T cell–mediated IFN-γ responses, the contribution of γδ T cells to mucosal immunity and vaccine-induced protection remains poorly defined. The objective of this study was to characterize the role of γδ T cells during primary pulmonary infection with F. tularensis live vaccine strain (LVS) and following intranasal immunization with inactivated F. tularensis (iFt) prior to LVS challenge.

Using a murine intranasal infection …

Nathaniel Hawthorne And The Limits Of Half-Feminism, Jessica Mckenzie

Seton Hall University Dissertations and Theses (ETDs)

This project argues that while Nathaniel Hawthorne creates intellectually complex and emotionally resilient female heroines in The Scarlet Letter and The Blithedale Romance, he ultimately reinforces the patriarchal structures he appears to critique. Through the figures of Hester Prynne and Zenobia, Hawthorne demonstrates a deep awareness of women’s societal oppression and the limitations imposed upon them within nineteenth-century America. However, despite moments of resistance and autonomy, these women are never permitted full liberation, agency, or lasting fulfillment. Their narratives ultimately become constrained by the patriarchal power that denies them independence and sustaining love. Thus, Hawthorne’s work coincides with the …

(The) Invisible Threads: Portraiture, Memory, And Relational Endurance, Behnaz Ghasempour

Masters Theses, 2020-current

(The) Invisible Threads is an MFA thesis investigating how invisible interpersonal bonds, collective traces, and communal endurance can be made perceptible through drawing, material, and immersive installation. Drawing from my lived experience as an Iranian woman who has witnessed everyday constraint, collective uprising, and migration, the project asks how the presence of others continues to inhabit the body and shape identity even in conditions of separation and distance. Large-scale self-portraits, layered with other faces on transparent fabrics, copper plates, and stitched threads, position the artist’s own body as a site where personal and collective histories converge, allowing the self to …

Ecological And Nutritional Drivers Of Floral Fidelity In Wild Pollinators, Adelaide Elise Ergastolo

Master's Theses

Plants must receive pollen from the same species in order to successfully reproduce. For most flowering plants, the transfer of pollen occurs via animal pollinators while they forage on plants to obtain food. Therefore, the fidelity of pollinators to individual plant species during foraging trips is directly related to the amount of conspecific pollen plants receive. Low floral fidelity of pollinators can reduce plant reproductive success, which in turn has the potential to lower food resources for pollinators in the future. While many factors can potentially influence pollinator floral fidelity, several important ones may be the nutritional resources provided by …

Longitudinal Changes In Cognition And Brain Imaging In Persons With Human Immunodeficiency Virus, James Kennedy, Sarah A Cooley, June Roman Fox, Kalen J Petersen, Elizabeth Westerhaus, Pat Reid, Linet Lopez, Beau M Ances

2020-Current year OA Pubs

BACKGROUND: As persons with human immunodeficiency virus (PWH) live longer, interactions between human immunodeficiency virus (HIV), aging, and structural brain integrity become increasingly vital for understanding cognitive disorders. This study analyzed the effects of aging, HIV serostatus, and viral load on cognition and brain volumes in a large cohort of persons without HIV (PWOH), PWH with undetectable virus (PWHU) (HIV RNA ≤50 copies/mL), and PWH with detectable virus (PHWD) (HIV RNA >50 copies/mL). Cross-sectional and longitudinal data were included.

METHODS: Cognitive composites (NPZ4) and brain volumes were obtained from 259 PWOH, 264 PWHU, and 84 PWHD with a total of …

Impact Of Travel Time To Health Facilities On Perinatal Outcomes: A Systematic Review With Narrative Synthesis And Meta-Analysis, Sanam Roder-Dewan, Marwa Ramadan, Paul Ouma, Alexander Manu, Emelda A. Okiro, Natalie Strobel, Bibian N. Robert, Emily Odipo, Peter M. Macharia, Anthony Danso-Appiah, David C. Goodman, Queen Dube, Gagan Gupta, Hema Magge, Karen Edmond

Research outputs 2022 to 2026

Background: Evidence-based global guidance on safe travel time for small or sick newborns who require transfer to health facilities after birth is lacking. A two-hour threshold is frequently cited in low- and middle-income countries (LMICs), while 30 minutes is commonly used in high-income countries (HICs). Although these thresholds are widely referenced, their empirical basis and consistency across levels of newborn care and journey types have not been systematically examined. This study synthesises the evidence linking travel time and perinatal outcomes. Methods: We conducted a systematic review with narrative synthesis and meta-analysis to assess the impact of travel time or distance …

Effects Of Melatonin Supplementation On Exercise Induced Stress In Horses, Hannah Clark Valigura

Theses and Dissertations

Exercise is a necessary component of athletic conditioning but imposes substantial physiological stress on horses, resulting in oxidative stress, inflammation, muscle damage, and thermal strain that can impair performance and recovery. Melatonin, a neurohormone with potent antioxidant and thermoregulatory properties, has been proposed as a novel nutritional strategy to mitigate these effects. This dissertation aimed to (1) characterize serum melatonin concentrations following oral supplementation, (2) evaluate the effects of melatonin on oxidative stress, inflammation, and muscle damage biomarkers after exercise, and (3) examine its influence on physiological parameters during exercise under warm weather conditions. Across a series of controlled experiments …

Integrating Augmented Reality Visualizations Into Data Science Notebooks Using Microsoft Hololens 2, Derek Willis

Theses and Dissertations

Data-science notebooks support iterative analysis but are limited to two-dimensional (2D) displays. This work presents an approach to extend such environments with rapid augmented reality (AR) visualization while preserving conventional 2D workflows. An opensource R package was developed to convert notebook objects into three-dimensional (3D) models, export them in the Graphics Language Transmission Format (glTF), and transfer directly to a Microsoft HoloLens 2 via a USB connection for viewing in the native 3D Viewer application. The proposed workflow eliminates manual conversion and transfer steps required by earlier methods. A user study employing a post-session questionnaire indicated that participants found the …

Delayed Timing Of Spring Application Of Nitrogen In Corn, Elizabeth Mae Worley

Theses and Dissertations

Application timing of nitrogen (N) fertilizer within the corn growing season can be crucial to crop nutrient uptake and availability. A lack of region-specific timing recommendations may result in inefficient fertilizer use and inconsistent yield responses. The objectives of this study were to determine how late in the growing season a first and second N fertilizer application can be pushed until corn yield is impacted and investigate whether Growing Degree Days (GDDs) should be used as better estimate of timing for N application than calendar date or growth stage. First applications were able to be delayed until V4-V6 growth stages …

Assessing The Relationship Between Subsurface Geology And Surficial Geomorphology: Remotely Predicting Geologic Features And Geohazards Using An Elevation-Trained Machine Learning Algorithm In The Northern Gulf Of Mexico, Allison L. Wing

Theses and Dissertations

This thesis evaluates the capacity to predict subsurface geologic features and submarine landslide susceptibility using surficial geomorphology derived from bathymetric elevation data in the Northern Gulf of Mexico. Quantitative geomorphic variables including slope, curvature, aspect, rugosity, geomorphons, and Bathymetric Position Index were generated from 30-meter digital elevation models and used as explanatory variables in presence-only Maximum Entropy models. Known locations of faults, pockmarks, mud volcanoes, hydrocarbon seeps, and landslides (particularly intact scarps) were used to train and validate predictive models through k-fold cross validation. Model performance was assessed using omission rates and AUC values. Results demonstrate that specific geomorphic signatures, …

Impacts Of Structural Design On Oyster Survival And Predation In Restored Oyster Reefs, Jaden Akers

Theses and Dissertations

Restoration efforts are critical to ensure healthy oyster populations, but the high cost and marginal success rate of many restoration efforts demonstrates the need to evaluate alternative oyster reef restoration designs and strategies. To address this issue, I conducted a paired field and mesocosm study to assess the influence of structural design on oyster survival and predation. Results of the field portion of this study showed that oyster survival was greatest in short and bed-level (i.e., sitting on the sea bottom) reef designs. When assessing how design features impact oyster drill activity, elevated reefs (i.e., elevated above the sea bottom) …

Community Development Professionals’ Perceptions Of Agritourism In Mississippi, Emma Jane Berry

Theses and Dissertations

Agritourism has emerged as a strategy for supporting rural economies, strengthening community identity, and increasing agricultural literacy. Although prior research has examined agritourism operators and visitors, limited attention has been given to the perceptions of community development professionals who influence local planning and program support. The purpose of this qualitative exploratory study was to examine community development professionals’ perceptions of agritourism’s role in community development, economic growth, and agricultural literacy in Mississippi. Guided by Social Exchange Theory, data were collected through two semi-structured virtual focus groups with 12 professionals representing Extension, tourism, economic development, and Main Street organizations. Data were …

Assessing Differences In The Frequency And Severity Of Osteoarthritis On The Mandibular Condyles Between Males And Females At Tell Abraq, Brittany C. Brown

Theses and Dissertations

Tell Abraq, a Bronze and Iron Age site in the United Arab Emirates, was a center of trade and cultural expansion during the Umm an-Nar period (2700–2100 BCE). Its multichambered tombs contain large, commingled burials, reflecting increasing sedentism and agricultural practices. This study examines mandibular osteoarthritis (OA) to explore lived experience and biomechanical stress. A total of 138 adult mandibles were analyzed for sex and OA severity. Results show generally mild and infrequent OA, though preservation limited analysis. Sex estimates suggested more gracile morphologies than previously identified. No strong sex-based differences in OA were observed. Overall, findings highlight the impact …

Determining Agricultural Literacy Proficiency Of Extension Professionals And Primary Volunteers In Mississippi, Molly Campbell

Theses and Dissertations

The development of agricultural literacy is a lifelong process, moving from gaining agricultural knowledge to communicating with others to applying to societal issues, and extends beyond the formal classroom. The Mississippi State University Extension Service has the ability to reach various audiences through educational programming, making them a potential catalyst for change in increasing agricultural literacy across the state. The study aims to determine the agricultural literacy levels of Extension professionals and primary volunteers in Mississippi and the factors potentially influencing these levels. Twenty-nine Extension professionals and eleven primary volunteers completed a survey of demographic questions and the Judd-Murray Agricultural …

Investigating Teacher Cognition Of Teaching Spatial Thinking Among Middle And High School Stem Teachers: A Knowledge, Belief, And Attitude Perspective, Jonathan Grant Harris

Theses and Dissertations

Spatial thinking is a critical cognitive ability that supports learning and problem solving across science, technology, engineering, and mathematics (STEM) disciplines. Despite extensive research highlighting the importance of spatial thinking in STEM achievement and career success, limited research has examined STEM teachers’ cognition of spatial thinking or developed instruments to measure it. The purpose of this study was to investigate middle and high school STEM teachers’ cognition of spatial thinking, including their perceived pedagogical content knowledge (PCK) of spatial thinking, self-efficacy beliefs about teaching spatial thinking, and attitudes toward spatial thinking as a critical component of STEM learning and achievement. …

Mapping And Measuring Sidewalk Network Connectivity In Starkville, Mississippi: The Role Of Policy-Required Development, Public Investment, And Destination Access, Isabella R. Jones

Theses and Dissertations

Sidewalks support pedestrian mobility, public health, social community, and access to destinations, but few studies explore sidewalk connectivity in small cities. This study examines changes in sidewalk network connectivity in Starkville, Mississippi after the adoption of a sidewalk ordinance in 2009. Using ArcGIS Pro, a dataset of the city’s sidewalk network was created and used to analyze changes in the network between 2009 and 2024. Sidewalks were given connectivity ratings using a system that considered physical connections to the network as well as proximity to important destinations such as grocery stores, parks, schools, bus stops, and the city’s hospital. The …

Investigating Semantic Categorization Using Fast Periodic Visual Stimulation, Zack Murphy

Theses and Dissertations

Fast periodic visual stimulation (FPVS) with EEG provides a rapid method for isolating both higher-order and lower-order cognitive responses, an advantage that could prove useful in future research into higher order cognitive tasks. This thesis tested whether a semantic categorization response could be reliably differentiated from a low-level color response. EEG data were collected while 33 young adults viewed image sequences of fruits and vegetables of varying colors across five experimental conditions that compared color and semantic categorization responses. Frequency domain analysis revealed that color responses were much stronger and localized to the Left Occipito-Temporal (LOT) region of interest (ROI) …

Plasma Pharmacokinetics Of Topical 0.1% Diclofenac Sodium And 0.5% Ketorolac Tromethamine In Dogs, Jacqueline Peraza

Theses and Dissertations

To determine plasma concentrations of ophthalmic 0.1% (w/v) diclofenac sodium and 0.5% (w/v) ketorolac tromethamine following 4 times daily ophthalmic administration in healthy dogs. Eight dogs were randomly assigned to a diclofenac or ketorolac group. Plasma was collected before drug administration. Plasma samples were collected after the 4 pm treatments on days 1 and 5. Plasma concentrations (ng/mL) were quantified by liquid chromatography-mass spectrometry and analyzed with noncompartmental pharmacokinetic analysis. After ophthalmic administration of 0.1% diclofenac, mean t1/2, Tmax, and Cmax occurred at 3.08 0.9 hours, 121.4 2.8 hours, 0.12 0.05 ug/mL, respectively. The mean t1/2, Tmax, and Cmax after …

Characterizing The Microbial Structure And Function In Black Soldier Fly Digested Dairy Manure And Subsequent Larvae, Branden N. Pierce

Theses and Dissertations

This work examined the microbial structure and gene expression found in Black Soldier Fly larval guts and their frass when reared on dairy cattle manure that had been amended with either R. rhodococcus 21198, P. polymyxa 8158, or both and compare the results to larvae reared on untreated manure. First an overview of literature surrounding projected global food supplies and the possible use of insects to either increase them or mitigate the environmental effect of producing said supply. A cellulose degradation assay was performed to assist in determining which bacterial species to use as amendments. Characterization of the microbial communities …

Attentional Prioritization And Refreshing As Pathways To Long-Term Memory Formation, Pouria Rahgosha

Theses and Dissertations

Attention regulates which information in working memory becomes stabilized in long-term memory. Two candidate mechanisms are attentional prioritization and attentional refreshing. Although both reliably benefit working memory, their contribution to long-term memory remains unclear. Two experiments examined this issue using an associative memory paradigm in which participants encoded image-keypress pairs, maintained them under varying conditions, and completed both working memory and unexpected cued-recall tests. Experiment 1 manipulated refreshing indirectly by varying attentional load during maintenance, whereas Experiment 2 contrasted implicit and explicitly cued refreshing. Across both experiments, prioritization consistently improved working memory performance. However, prioritization benefited long-term memory only when …

Evaluation Of Soybean (Glycine Max (L.) Merr.) Response Following Simulated Damage, Brittany Rhea

Theses and Dissertations

Deer damage to row crops has been an ongoing issue in the state of Mississippi, and hail damage can be catastrophic. The objective of this research was to evaluate soybean response following simulated deer and hail damage at specific growth stages and damage levels. Soybean yield response to deer damage indicates the singular feedings of 75 % results in a loss of up to 2688.32 kg ha-1 in most scenarios, and continual feeding at the 50 % level leads to a yield reduction of up to 2168.81 kg ha-1 in all scenarios. Hail damage at V3 and R1 growth stages …

Liposomal Bupivacaine Caudal Epidural In Horses Results In Adverse Effects Without Analgesia, Christopher Stokes

Theses and Dissertations

Liposomal bupivacaine (10 mL; 1.3%) was administered into the caudal epidural space via an indwelling epidural catheter. Mechanical nociceptive threshold (MNT) testing with pressure algometry was used to measure analgesia at 4 anatomic locations for 72 hours following injection. Physical examinations were performed and ataxia scores recorded every 4 h to monitor for adverse effects, and fecal and urine output were recorded. There were no significant differences at any time point in rectal temperature, heart rate, respiratory rate, or MNT at any anatomic site compared to baseline. Ataxia scores were significantly elevated from 24 to 36 h following epidural injection. …

Impacts Of Goat Grazing On Coastal Upland Understory, Maya Stratman

Theses and Dissertations

Coastal upland pine savannas and flatwoods along the northern Gulf of Mexico are biodiversity hotspots degraded by woody encroachment following fire suppression and loss of herbivory. Conservation grazing has been proposed as a management tool, yet its effectiveness in these systems remains understood. This study evaluated how goat grazing frequency and duration influence understory vegetation structure, diversity, productivity, and light availability in an Ilex-dominated coastal upland in Mississippi. Five grazing treatments (monthly, every three months, biannual, seasonal, and ungrazed control) were applied across 25 plots over one year. Vegetation percent cover, genus richness, Normalized Difference Vegetation Index, light penetration, and …

Variation In The Sonographic Appearance Of The Liver In Cats With Lymphomatous Hepatic Infiltration., Charlee Sturkie

Theses and Dissertations

Lymphoma is the most diagnosed neoplasm in domestic cats, and abdominal ultrasound is often included as a component of the diagnostic plan. The aim of this study was to determine if changes in sonographic appearance of the liver as well as the presence of free fluid, lymphadenopathy, and splenic abnormalities increase the likelihood of diagnosis of lymphomatous hepatic infiltration in cats diagnosed with lymphoma. Fifty-eight cats were enrolled in this combined retrospective and prospective study, 22 with lymphomatous infiltration in the liver and 36 without. In the current population hypoechogenicity, heterogeneous echotexture, hepatomegaly, and the presence of nodules within the …

Gut Dysbiosis And Microbial Metabolites In Atopic Dermatitis: Implications For Immune Regulation Along Gut-Skin Axis, Khushbakhat Alia, Hira Khan, Hamna Muzaffar, Nighat Perveen, Sara Alrashedi, Yusra Al Dhaheri, Yasir Waheed, Mohammed Tauqeer Alam, Muhammad Naseem, Khalid Muhammad

All Works

Atopic dermatitis (AD) is a multifactorial skin disorder characterized by immune dysregulation, impaired epidermal barrier, and strong microbial imbalance. Although genetic susceptibility and environmental triggers are established AD drivers, growing evidence highlights the gut skin axis as an important but underexplored AD pathogenesis factor. Gut microbiota dysbiosis, loss of short-chain fatty acid (SCFA)-producing bacteria, and altered metabolite profiles, such as tryptophan derivatives and secondary bile acids, have been linked to systemic immune imbalance and skin inflammation. However, the precise mechanism by which gut microbial alterations influence cutaneous immunity remains unclear. This review synthesizes recent advances from clinical and experimental studies …

Harnessing Mechanobiology Of Resident Stem Cells To Refine Cell Based Therapeutics, Dakota R. Kamm

WUSM Theses and Dissertations – All Programs

Mesenchymal stem cells (MSCs) are resident cells residing with many adult tissues such as adipose tissue and bone marrow that have the potency for multiple lineage differentiation as well as the capacity to secrete a litany of beneficial factors to maintain homeostasis and promote tissue repair. Since 1995, MSCs have been used therapeutically to treat a variety of conditions from osteoarthritis to heart disease to muscle pathologies. Great leaps have been made in improving MSC-based therapies through optimization of culture methods and select enrichment of cellular subpopulations. More recently, the physical microenvironment of tissue in vivo and culture conditions in …