Digital Commons Network^™

The Neuroprotective Effect Of Cdc42 Inhibition In The G93a Mutant Hsod1 Mouse Model Of Als, Andrea Koly

Undergraduate Theses, Capstones, and Recitals

Amyotrophic lateral sclerosis (ALS) is a progressive and fatal neurodegenerative disease characterized by the selective loss of upper and lower motor neurons, leading to muscle weakness, neuromuscular junction (NMJ) degeneration, paralysis, and eventual death due to respiratory failure. Despite extensive research, effective disease-modifying therapies remain limited, underscoring the need to identify novel molecular targets involved in ALS pathogenesis. Dysregulation of Rho family GTPases has been implicated in neurodegeneration, with Rac and Rho exerting opposing effects on neuronal survival; however, the role of the closely related GTPase Cdc42 remains poorly understood in ALS. In this study, the therapeutic potential of inhibiting …

Semantic Directing: A Human-Ai Workflow For Interative Virtual Cinematography, Lejie Liu

Dartmouth College Master’s Theses

This thesis presents AI Director, a Unity-based prototype for semantic directing in virtual cinematography. The system enables creators to describe cinematic intent in natural language, receive editable shot-strategy plans generated by a large language model, and refine specific shots through text and visual references. By separating semantic planning from deterministic camera execution, the workflow keeps user authorship centered on shot intent while making the resulting camera plans inspectable, editable, and executable in real time. This work explores semantic directing as a human-AI workflow for iterative cinematic authoring in dynamic 3D scenes.

Policy Solutions In The Ev Battery Supply Chain Addressing Unethical Social And Environmental Practices, Mateo Mazariego-Halpern

Undergraduate Theses, Capstones, and Recitals

California should adopt a phased supply chain accountability framework for electric vehicles sold in the state, combining the immediate implementation of a voluntary Fair Trade Decal program with the mandatory adoption of COFFEE (Corporate Operations Free From Environmental Evil) Standards based on CAFÉ standards, by 2035. This thesis identifies a critical gap in U.S. EV policy: current federal legislation regulates where batteries are sourced but not how cleanly or ethically they are produced. The consequences of this regulatory gap are severe, with emissions simply shifting further down the supply chain rather than being eliminated, child labor and indigenous displacement going …

Collaboration In Conservation: Examining Environmental Policy Perspectives Among Ranchers In Rural America, Adeline Braun

Undergraduate Theses, Capstones, and Recitals

Rural Americans play an essential role in environmental protection policy in the United States due to their political influence and their management of large amounts of land. This study examines what factors affect rural support for and opposition to environmental management policies in order to gain a deeper understanding of when and why rural Americans support and oppose certain environment-related policies. Data collected from interviews with seven current and former ranchers in Wyoming along with information gathered from three relevant environmental organizations is analyzed through the lenses of economics, partisan politics, rural identity, and policy framing. The findings of this …

Differential Roles Of Moesin And Vasp In Β-Catenin-Associated Networks During Zebrafish Heart Regeneration, Allen Rutman

Undergraduate Theses, Capstones, and Recitals

With cardiovascular disease remaining as the leading cause of mortality worldwide, it is largely due to the limited regenerative capacity of the human heart. However, zebrafish (Danio rerio) can fully regenerate cardiac tissue following injury, providing a valuable model for studying the mechanisms of heart repair. To investigate these mechanisms, we used proteomics methods in the past. Proximity labeling is a technique that identifies proteins based on their physical proximity to a protein of interest. It can be applied in organisms and in living cells (Roux et al., 2012; Cho et al., 2020). We used proximity labeling to characterize protein …

Sediment: A Magical Realist Road Novel, Nicolas Victor Rago

Dartmouth College Master’s Theses

This magical realist novel follows G and Louie, two strangers, as they road trip west to east across the continental United States. As they travel, they drift through time, exploring historical and personal pasts through surreal atmospheric prose.

Fluorescence Cryotomography For Preclinical Validation: Applications In Gene Therapy And Fluorescence-Guided Surgery, Caleb Y. J. Kwon

Dartmouth College Ph.D Dissertations

Fluorescence imaging has become a powerful tool in biomedical research and clinical practice, offering molecular specificity and high sensitivity for visualizing biological processes in real time, However, the successful translation of novel fluorescent probes or medicines from preclinical development to clinical applications requires rigorous validation of their biodistribution and target specificity. Traditional methods for assessing performance, such as bulk excised organ analysis or two-dimensional histology, provide limited information as they cannot capture the complete, organism-wide distribution of these probes or medicines. This thesis aims to improve this analysis pipeline through the application and optimization of fluorescence cryotomography for quantitative, high-resolution …

Antimicrobial Susceptibility And Targeted Molecular Detection Of Methicillin Resistance Determinants In Staphylococcus Spp. Isolated From Broiler Bco Lesions, Woro Wulandari Kalanjati, Chrystalee Ailani Alvarez, Anh Dang Trieu Do, Adnan Ali Khalaf Alrubaye

School of Integrative Biological & Chemical Sciences Faculty Publications

Background/Objectives: Antimicrobial resistance (AMR) in Staphylococcus spp. associated with poultry production is an emerging concern with implications for animal and public health. This study aimed to characterize antimicrobial susceptibility patterns and detect targeted methicillin resistance determinants in Staphylococcus isolates recovered from broiler chickens affected by bacterial chondronecrosis with osteomyelitis (BCO). Methods: A total of 200 bacterial isolates were evaluated, of which 167 were confirmed as Staphylococcus spp. Species identification was performed using presumptive phenotypic characterization followed by 16S rRNA gene sequencing. Antimicrobial susceptibility was assessed using disk diffusion, while presumptive methicillin-resistant phenotypes were evaluated using oxacillin screening and CHROMagar MRSA. …

Interrogating Settler Narratives Of Erasure In The Schatz Tree Farm Archives, Sangeeta Sarkar

IdeaFest: Interdisciplinary Journal of Creative Works and Research from Cal Poly Humboldt

In 1987, L. W. Schatz donated a 385-acre parcel of land to Cal Poly Humboldt to be used as an experimental station, outdoor classroom, and demonstration area for forestry educators and students. Previous student research and other institutional narratives have extensively documented the history of this land from a settler perspective. However, this documentation contains few mentions of the Indigenous history of the landscape. Through literature review and archival research, this paper critically analyzes settler colonial narratives around the Schatz Tree Farm and the ways in which they contribute to Indigenous erasure. The predominant forms of narrative erasure in settler …

Allosteric And Uncompetitive Inhibition Of Yeast Alcohol Dehydrogenase Identified By Enzyme Kinetics, Dylan Jeremy Harrison, Jenny A. Cappuccio

IdeaFest: Interdisciplinary Journal of Creative Works and Research from Cal Poly Humboldt

Enzyme kinetics is a powerful technique used to quantify the rate at which an enzyme converts a substrate into a product and to identify potential inhibitors. In this study, kinetic analysis was employed to assess the activity of yeast alcohol dehydrogenase (YADH) in the presence and absence of sweeteners commonly found in alcoholic beverages. YADH catalyzes the oxidation of ethanol to acetaldehyde using NAD⁺ as a cofactor; the reduction to NADH can be monitored spectrophotometrically at 340 nm. Based on structural similarities to the ribose moiety of NAD⁺, it was hypothesized that sucrose and sucralose could directly interact with the …

Full Issue, The Press At Cal Poly Humboldt

IdeaFest: Interdisciplinary Journal of Creative Works and Research from Cal Poly Humboldt

No abstract provided.

2nd National Research Day Lebanese Medical Schools

MEAMS Middle East Annals of Medical Sciences - Saint Joseph University of Beirut

No abstract provided.

Rural–Urban Disparities In Monkeypox-Related Behaviors And Attitudes Among Men Who Have Sex With Men, Patcharaporn Krainara, Benjamas Klahan, Rungrot Jaiyong, Jitti Hanprasertpong

Journal of Health Research

Background: Monkeypox (Mpox) is a global health threat, particularly among men who have sex with men (MSM). Despite the predominance of urban cases in Thailand, rural–urban disparities in Mpox-related attitudes and behaviors remain underinvestigated. This study aimed to compare Mpox-related attitudes and preventive behaviors among urban (Chonburi) and rural (Nakhon Nayok) MSM and identify their influencing factors.

Method: This cross-sectional study was conducted between March and April 2025. A total of  842 MSM (421 urban; 421 rural) were recruited via convenience sampling. Data were collected using paper-based, self-administered Health Belief Model (HBM) questionnaires and analyzed using descriptive statistics and multivariable …

One Step Further: An Overview Of Canada’S Past And Present Responses To Homelessness And The Argument For Alternative Conceptions Of Property Ownership, Logan Billard

Dalhousie Journal of Legal Studies

Homelessness in Canada continues to worsen year after year. Despite the shift from punitive, neoliberal policies to a human rights-based model, homelessness remains a national crisis. Federal initiatives like the National Housing Strategy Act and the Housing First Model aim to provide stable housing, but their impact remains limited. This paper explores the structural factors contributing to homelessness, including poverty, housing financialization, and systemic discrimination, particularly against Indigenous communities. It also highlights the limitations of the current human rights-based approach, focussing on the lack of enforceability and failure to create substantial, sustainable change due to systemic reliance on the financialization …

An Extension To A. Goldshtein, Et Al, 2025, Manish Rami

Communication Sciences & Disorders Faculty Publications

This note extends the findings reported in “Onboard recordings reveal how bats maneuver under severe acoustic interference” available at:

Goldshtein, Aya, et al. “Onboard Recordings Reveal How Bats Maneuver under Severe Acoustic Interference.” Proceedings of the National Academy of Sciences, vol. 122, no. 14, Apr. 2025, p. e2407810122. pnas.org (Atypon), https://doi.org/10.1073/pnas.2407810122.

The Growth Of Green Marketing Studies In Southeast Asia: A Bibliometric Review, Muh Erwin Syah, Nuryakin Nuryakin

ASEAN Marketing Journal

Research Aims: This study maps the intellectual structure and development of green marketing research in Southeast Asia. It identifies dominant research clusters and knowledge gaps and provides directions for future research.

Design/methodology/approach: The method used in this study is qualitative research with a literature study approach. The method used in this study is qualitative research with a literature study approach. The data source used in this study was taken from the Scopus database on May 25, 2025, with a publication timeframe (2014–2024). As for the data found, 3,872 publications were obtained and analyzed. Finally, this dataset was converted to RIS …

June 12, 2026 Ereporter, University Of Alabama At Birmingham

eReporter (campus newsletter)

No abstract provided.

The Palm Farm Next-Door: Land Concessions, Livelihoods, And Nutrition In Plantation-Adjacent Communities, Julia Entwistle

Electronic Theses and Dissertations

Large-scale land concessions have reshaped agrarian landscapes globally, yet their implications for community land tenure, livelihoods, and nutrition remain unevenly understood. This dissertation examines how plantation agriculture and foreign investment have transformed land access, labor relations, and food systems in Liberia, a country with one of the highest proportions of land under concession globally. Guided by a political ecology framework, the study employs a mixed-methods design integrating policy analysis, in-depth interviews, and household surveys across two palm oil concession sites. The findings show that ambiguous land policies historically facilitated dispossession, while recent legal reforms have enabled communities to strategically mobilize …

Open Materials For Ant-Psy 210, Sex And Culture, Melissa Zavala

Open Educational Resources

Sex and Culture explores the cultural construction of human sexuality from the framework of the individual in society. Students will examine the social learning of sexual behaviors, beliefs and practices. Analytic focus will include how culturally prescribed gender roles for men and women inform notions of right and wrong. Specific topics may include institutionalized gender inequality, marriage and the family, homophobia and other issues involved in the relationship between sex and culture. All topics will be considered from a historical and cross-cultural perspectives.

Interactive Social Game Design For Sustainability Learning, Kayla Mattson, Kayla Huffman, Megha Thottam, Shreeya Koritala

Computer Science and Engineering Senior Theses

Our Roots is a community-centered, web-based social game designed to improve sustainability education by turning everyday environmental actions into shared, visible progress. While many existing tools provide information about sustainability, they often focus on individual tracking and short-term motivation, which can lead to disengagement over time. This project addresses that gap by reframing sustainability as a social practice: users log real-world sustainable behaviors, earn points, and see those actions represented as growth in both personal and community digital gardens. By combining friendly competition, peer visibility, and collective outcomes, the platform encourages users to view sustainability not as an isolated task, …

Biol A112l Human Anatomy And Physiology Ii Laboratory Syllabus, Kathleen Nevis

Publications

Human Anatomy and Physiology II Laboratory syllabus with links to open access textbook.

Food System Science Lesson-1 For First Graders. Makhá Waókiyapi: Soil Helpers, Feeding The Land That Feeds Us (Lesson About Regenerative Agriculture), Arlene A. Abao, Madhav P. Nepal

iLEARN Teaching Resources

In this engaging Grade 1 Science adventure, students become "Earth Doctors" as they discover that the soil beneath their feet is a living, breathing community! Guided by the Lakota value of Mitákuye Oyás’iŋ (all are related), children will learn that Makhá (the Earth) is not just "dirt," but a relative that provides us with everything we need to live. Students will get their hands dirty investigating the "Soil Helpers"—the worms, roots, and tiny bugs that work like a team to keep the land healthy. They will explore the three golden rules of being a good neighbor to the Earth: Compost …

Food System Science Lesson-2 For First Graders. Makhózula Etáŋhaŋ Wiyútapi Ke: From Planting To Eating, Arlene A. Abao, Madhav P. Nepal

iLEARN Teaching Resources

Feeding the Land That Feeds Us In this delicious adventure, kids will trace the journey of their food from the deep, dark soil all the way to their lunch forks! They will discover that the land is like a giant, magical kitchen called Makhózula, where plants cook up energy using sunlight and "vitamins" from the soil. Students will learn that when we eat a crunchy carrot or a sweet berry, we are actually tasting the strength of the Earth and the warmth of the sun. Through stories of Wopila (gratitude), they’ll see that the food system is a big, …

Food System Science Lesson-3 For First Graders. Mitakuye Oyasin: The Invisible Web (We Are All Related, An Ecological Knowledge Lesson), Arlene A. Abao, Madhav P. Nepal

iLEARN Teaching Resources

 In this heart-centered science lesson, students will discover the beautiful Lakota concept of Mitakuye Oyasin, which teaches us that "we are all related." Rather than seeing nature as a collection of separate things, children will learn to see the Invisible Web, the magical connections between the sun, soil, water, plants (flora), and animals (fauna). Through a hands-on "Yarn Web" activity and outdoor exploration, students will move beyond being just observers and start seeing themselves as stewards (caretakers) of their environment. They will learn that when we help a bee or protect a stream, we are helping our own Earth family. …

Flame Retardant Metabolites In Urine Samples Associated With U.S. Consumer Dietary Behaviors, Heather Marie Holliday

Walden Dissertations and Doctoral Studies

No abstract provided.

"I'Ve Just Re-Read The Aeneid Again": Virgil's Thematic Influence As Depicted In Katabatic Journeys In The Fiction Of C. S. Lewis, Henry Young

Theses and Dissertations

Inspired by his studies in Classical, Medieval, and Renaissance literature, C. S. Lewis incorporated echoes of Virgil in his fiction, especially in katabatic journeys. In his scholarship, he identified Virgil's Aeneid as "secondary epic" which contains the Christian-like theme of vocation in the face of transition. Traces of this theme are evident in Lewis's fiction, expressed through mythical katabatic imagery. Katabasis, for Lewis, appears as a Pagan pattern fulfilled in Christ and experienced by His disciples through conversion. Lewis's characters, though ordinary people, must learn to accept divinely given vocations which then propel them into katabatic sequences that inspire belief …

Ka Here Tāngata:1 Mātauranga And Te Ao Māori In Biocultural Kākāpō (Strigops Habroptilus) Conservation Approaches, Sophie Perfetto

Electronic Theses and Dissertations

This master's thesis examines conservation as a form of living cultural heritage practice through the co-management of kākāpō (Strigops habroptilus), a critically endangered parrot and taonga species in Aotearoa New Zealand. Situated within ongoing histories of colonial dispossession and Western frameworks of land and species management, contemporary kākāpō conservation is shaped through the partnership between the Department of Conservation’s Kākāpō Recovery Programme and Ngāi Tahu. Drawing on semi-structured interviews collected during fieldwork from July to August 2025, this study examines how institutional partnerships structure decision-making, authority, and responsibility in contemporary conservation governance. Findings demonstrate that Māori knowledge systems …

Tracing The Flow Of Value In Ecotourism: A Case Study Of Lekki Conservation Center, Lagos, Nigeria, Queen Oluwatobi Olafadehan

Electronic Theses and Dissertations

This study examines the flow of value in ecotourism at Lekki Conservation Center (LCC) in Lagos, Nigeria, using a political ecology framework to analyze how economic benefits, participation opportunities, and environmental impacts are distributed among different community groups. Drawing on semi-structured interviews with 16 community members, participant observation, and photographic documentation, the study investigates how surrounding communities perceive and experience ecotourism, how revenue is understood to be distributed, and in what ways communities are included in or excluded from conservation decision-making. The findings reveal that ecotourism at LCC generates benefits that are unevenly distributed, that community participation in governance remains …

Diet And Microbiome Shape Small-Molecule Cytokinin Pools In Mammals, Eman M. Othman, Elena Bencurova, Pamela Ferretti, Peer Bork, Alvaro Rodriguez Del Rio, Jaime Huerta-Cepas, Ignazio Caruana, Rania Abdel-Latif, Aman Akash, Alfonso Albacete, Feras Lafi, Thomas Dandekar, Muhammad Naseem

All Works

Cytokinins (CKs) are adenine-derived metabolites traditionally characterized as plant hormones, yet their origin, distribution, and functions in mammalian systems remain largely undefined. Using integrated metabolomics, microbiome, and metagenomics approaches, we provide a systematic characterization of CK occurrence and potential sources in mammals. Serum profiling across five animal species revealed consistent detection of multiple CK derivatives, with concentrations markedly lower than in plant tissue. The CK storage form, zeatin-O-glucoside, predominated in mammalian sera, followed by trans-zeatin and kinetin, indicating a CK composition distinct from that in plants. Species-specific differences, such as reduced trans-zeatin in mice and lower kinetin in humans, further …

Reseeding Relations: Comparing Museum And Indigenous Seed Sharing & Rematriation Protocols In The Midwestern United States, Madeline G. Anderson

Electronic Theses and Dissertations

While the Native American Graves Protection and Repatriation Act (NAGPRA) paved the way for the repatriation of ancestors and certain cultural objects to Indigenous communities, museums still struggle to address other forms of cultural returns. Heritage seeds, those which hold cultural significance to Indigenous peoples, held within museum collections perpetuates the colonization of Indigenous lifeways. This research examines rematriation as an Indigenous form of cultural return better suited to address these needs than limited repatriation models. I analyze how museums are working to create rematriation processes for their collections which reflect diverse Indigenous epistemologies and ontologies through a three-tiered approach: …