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Articles 2911 - 2940 of 14349
Full-Text Articles in Entire DC Network
Folr1-Targeted Actinium-225-Based Alpha-Particle Therapy Eliminates Ovarian Cancer, Neetu Singh, Esther Need, Ayden Berndt, Matthew Goff, Lydia J. Wilson, Firas Mourtada, Feng Guo, Tara Mastren, Taslim Al-Hilal, Anil K. Sood, Amit Maity, Scott C. Miller, Satoshi Minoshima, Shreya Goel, Sixiang Shi
Folr1-Targeted Actinium-225-Based Alpha-Particle Therapy Eliminates Ovarian Cancer, Neetu Singh, Esther Need, Ayden Berndt, Matthew Goff, Lydia J. Wilson, Firas Mourtada, Feng Guo, Tara Mastren, Taslim Al-Hilal, Anil K. Sood, Amit Maity, Scott C. Miller, Satoshi Minoshima, Shreya Goel, Sixiang Shi
Department of Radiation Oncology Faculty Papers
Despite the advancement in therapies, ovarian cancer treatment is challenging because of poor prognosis and high relapse associated with acquired resistance. Emerging targeted alpha particles, particularly actinium-225 (225Ac), for treating refractory cancers have opened avenues for improved therapeutic options. Here, we describe a successful example of folate receptor 1 (FOLR1)–targeted 225Ac alpha-particle therapy for treatment of ovarian cancer. Longitudinal positron emission tomography imaging demonstrated high tumor-specific uptake of αFOLR1 (anti-FOLR1 antibody) in SKOV3 xenografts. FOLR1-targeted 225Ac demonstrated high therapeutic efficacy, achieving marked tumor regression, 80% survival, and 40% complete tumor elimination. The therapy resulted in tumor-specific double-stranded DNA damage, and …
Investigating The Role Of Cellular Senescence On Vestibular Dysfunction In Repetitive Mild Traumatic Brain Injury, Michael Volyanyuk
Investigating The Role Of Cellular Senescence On Vestibular Dysfunction In Repetitive Mild Traumatic Brain Injury, Michael Volyanyuk
Dissertations
Vestibular dysfunction is a prevalent and persistent consequence of mild traumatic brain injury (mTBI). Clinical reports reveal that women experience vestibular deficits more frequently than men following mTBI. Despite the high prevalence and debilitating nature of vestibular symptoms, preclinical literature evaluating mTBI-associated vestibular impairments is limited. Emerging evidence demonstrates that cellular senescence is involved in the pathological molecular sequela of mTBI. It has been shown that senescence contributes to cognitive deficits following repetitive mTBI (rmTBI); however, its role in rmTBI-associated vestibular dysfunction remains unexplored. This body of work investigated the role of cellular senescence on rmTBI-induced vestibular dysfunction in both …
Knowing And Being Known: Monstrosity And Relationality In Mary Shelley's Frankenstein, Rachel Carpenter
Knowing And Being Known: Monstrosity And Relationality In Mary Shelley's Frankenstein, Rachel Carpenter
Dissertations - ALL
This dissertation looks at Mary Shelley’s 1818 novel Frankenstein as a prime example of the ways character relations and narrative form can invite both characters and readers to renegotiate the boundaries of monstrosity and humanity, how our notions of such monstrosity and humanity are constituted dynamically, through relationships, and how this negotiation is itself a religious relational dynamic. By closely reading Mary Shelley’s novel, I consider three main facets of the work: the epistolary frame of the novel as a series of letters and stories relayed between characters, the practice of naming that takes place within the novel, and the …
Press To End Nightmare: Technology, Disfigured Labor, And Retail Grocery Work, Katherine Mott
Press To End Nightmare: Technology, Disfigured Labor, And Retail Grocery Work, Katherine Mott
Dissertations - ALL
This study attends to the lived experiences of retail grocery customer service workers to examine how economic forces, namely the growth of online retail and technological advancements in information systems and data collection, are reshaping retail work. It draws upon in-depth interviews, content analysis, and eight months of participant observation working alongside predominantly college-educated customer service workers at Whole Foods Market, an upscale retail grocery chain with hundreds of locations across the United States, Canada, and the United Kingdom. Prior to the 2010s, Whole Foods Market’s decentralized management structure successfully deployed a hegemonic “post-industrial work ethic” rooted in environmentalism, organic …
Peptide And Peptide Bioconjugate Based Drug Development For The Treatment Of Metabolic Diseases, Nancy Cham
Peptide And Peptide Bioconjugate Based Drug Development For The Treatment Of Metabolic Diseases, Nancy Cham
Dissertations - ALL
The Doyle group has coined the term ‘corrination’ to describe the conjugate modification of a peptide, protein, small molecule, or radionuclide with a corrin ring-containing molecule such as cobalamin, also known as vitamin B12 (B12), or cobinamides. By exploiting the innate chemico-physical properties of corrin ring-containing compounds, both in general and specifically via the innate dietary B12 uptake pathway in mammals, corrination has been explored for drug development and targeted/localized delivery of probes and therapeutics. Most recently, it is in the field of peptide-based therapeutics that corrination is generating significant interest, no doubt driven in part by the recent successes …
Marble Bodies: Sculpture, Gender, Race, And Nineteenth-Century U.S. Literature, Madeline Olley
Marble Bodies: Sculpture, Gender, Race, And Nineteenth-Century U.S. Literature, Madeline Olley
Dissertations - ALL
Marble Bodies reads across both literary texts and sculptures to ask how sculptural logic operates across forms to reveal what sculptors and sculpture offer the field of nineteenth-century U.S. literary studies—formally, theoretically, and methodologically. It argues that sculpture functions not merely as subject matter within nineteenth-century American literature but as an interpretive framework that reveals how bodies are objectified, valued, and assigned cultural meaning. With attention to the formal and material properties of sculpture—stillness, smoothness, and duration—and to the questions of ideality, valuation, and preservation that sculpture generates, this dissertation shows how nineteenth-century writers and artists found in those properties …
Neural Feature Crossing For Cross-Domain Recommendation In Knowledge Management Systems, Imran Khaled, Faiez Gargouri
Neural Feature Crossing For Cross-Domain Recommendation In Knowledge Management Systems, Imran Khaled, Faiez Gargouri
Baghdad Science Journal
Recently, the rapid growth of digital knowledge resources has created an urgent need for advanced recommendation systems that capable to operate across various domains. This paper introduces KnowledgeXRec, a domain-aware hybrid recommendation framework that models both shared and domain-specific user-item interactions within a unified end-to-end architecture. Domain-specific feature crosses capture patterns unique to educational and cultural domains, while shared layers enable cross-domain knowledge transfer. Learnable embedding is represented categorical features such as learning style, age group, and content attributes, and the model is jointly optimized using binary cross-entropy loss with Adam optimizer. Findings provide evidence that KnowledgeXRec consistently outperforms seven …
Predictive Mobility-Aware Analysis Of Controller Overhead In Sdn-Enabled Iot, Abdulrahman Saidu, Kamalrulnizam Bin Abu Bakar, Babangida Isyaku, Muhammad Nura Yusuf, Farkhana Binti Muchtar
Predictive Mobility-Aware Analysis Of Controller Overhead In Sdn-Enabled Iot, Abdulrahman Saidu, Kamalrulnizam Bin Abu Bakar, Babangida Isyaku, Muhammad Nura Yusuf, Farkhana Binti Muchtar
Baghdad Science Journal
The rapid growth and increasing mobility of Internet of Things (IoT) mobile devices significantly intensify flow setup requests in Software-Defined Networking (SDN). Frequent movement of mobile devices across access points triggers repeated flow rule installations in data-plane switches, leading to excessive controller overhead under limited flow-table memory capacity. Inaccurate mobility prediction in existing approaches further aggravates this challenge by causing unnecessary rule placement and redundant flow setup requests. This study investigates the impact of mobility-aware prediction on controller overhead with experimental scenarios using different groups of mobile IoT devices, while considering controller CPU and memory utilization. A proactive mobility prediction …
Data Scheduling Using Distance Function With Single-Pass Processing, Mahmood Shakir Hammoodi, Suhad Hatim Jihad, Mithal Hadi Jebur
Data Scheduling Using Distance Function With Single-Pass Processing, Mahmood Shakir Hammoodi, Suhad Hatim Jihad, Mithal Hadi Jebur
Baghdad Science Journal
Task scheduling is one of the most fundamental difficulties confronting numerous sectors, including education, healthcare, and industrial management. Scheduling quality has a direct impact on performance efficiency, resource utilization, and end user satisfaction. With the growing volume and diversity of data, there is a greater demand for intelligent systems that can handle the spatial and temporal complexity of jobs and resource allocation. As a result, modern data analysis and decision-making processes have become critical for ensuring workflow optimization while reducing time and space waste. This study proposes an innovative approach to task scheduling that combines multidimensional data analysis using Data …
Optimized Multi-Criteria Routing Algorithm For Durable Wireless Sensor Networks, Ghaihab H. Adday, Maha S. Abdulridha, Hasanain A. Alsreeh, Taj-Aldeen N. Abdali
Optimized Multi-Criteria Routing Algorithm For Durable Wireless Sensor Networks, Ghaihab H. Adday, Maha S. Abdulridha, Hasanain A. Alsreeh, Taj-Aldeen N. Abdali
Baghdad Science Journal
The Internet of Things and the Fourth Industrial Revolution (IR 4.0) rely on Wireless Sensor Networks (WSNs) as their underlying infrastructure. WSNs have recently attracted significant attention due to their crucial applications, such as monitoring applications. Geographic routing algorithms are widely used in WSNs because event location is often more critical than node identification. However, these algorithms still face challenges, such as workload imbalance and high energy consumption. Energy consumption is particularly vital in WSNs due to the sensor nodes' limited power resources. This work proposed an enhanced geographic routing algorithm based on the Technique for Order of Preference by …
Tlenet-Transformer For Epilepsy Detection With Futuristic Iomt Plans, Jayanthi Vajiram, Sivakumar. S
Tlenet-Transformer For Epilepsy Detection With Futuristic Iomt Plans, Jayanthi Vajiram, Sivakumar. S
Baghdad Science Journal
Temporal Lobe Epilepsy (TLE) is the most prevalent subtype of focal epilepsy, often posing diagnostic difficulties due to its complex clinical features. To address these challenges, this study proposes TLENet-Transformer, a novel deep learning architecture tailored for precise TLE identification. The study begins with skull stripping, bias field correction, z-score normalization, and Gaussian filtering; these methods are implemented to enhance image quality. Following this, a segmentation method based on an optimized Fuzzy C-Means clustering algorithm is employed, providing accurate delineation of regions. At this point, the segmented images are subsequently mapped to a pre-labelled Automated Anatomical Labelling (AAL) template to …
Weighted Average Ensemble Learning Model For Improving Brain Tumor Classification, Laith H. Alhasnawy, Hasanain Ali Al Essa, Tahseen A. Wotaifi, Abbas F. Hommadi, Ameer K. Al-Mashanji
Weighted Average Ensemble Learning Model For Improving Brain Tumor Classification, Laith H. Alhasnawy, Hasanain Ali Al Essa, Tahseen A. Wotaifi, Abbas F. Hommadi, Ameer K. Al-Mashanji
Baghdad Science Journal
The detection of Brain Tumors (BTs) is of great benefit in identifying the growth of dangerous cells in the brain that pose a threat to the patient's life. Early detection of BTs remains a significant challenge due to subtle differences among tumor types and the complexity of brain anatomy. Manual diagnosis by radiologists is often time-consuming and subject to variations, which may delay treatment. Among available imaging techniques, Magnetic Resonance Imaging (MRI) is widely used because of its high-resolution capabilities. Deep Learning (DL) has achieved remarkable success in image classification tasks through Transfer Learning (TL), which utilizes pre-trained models. Therefore, …
Pre-Freudian Recurrence: Photography And The Trace Before The Uncanny, Iwan Zahar, Karna Mustaqim, Salman Maulana, Irma Damayantie, Tri Wahyudi
Pre-Freudian Recurrence: Photography And The Trace Before The Uncanny, Iwan Zahar, Karna Mustaqim, Salman Maulana, Irma Damayantie, Tri Wahyudi
Bahasa dan Seni: Jurnal Bahasa, Sastra, Seni, dan Pengajarannya
This practice-led research proposes recurrence as a systematic photographic method, where Derrida's concept of iterability is achieved through controlled visual iteration. Through recurrence, identical objects undergo transformation across iterations because variations in light, motion and environmental conditions produce perceptual instability rather than visual sameness. This process produces uncanny effects identifiable through perceptual ambiguity (Jentsch), environmental transformation and reappearance of overlooked materials (Schelling). The work engages pre-Freudian concepts of the uncanny - Jentsch's intellectual uncertainty and Schelling's definition of the uncanny as ``something that should have remained hidden but has returned to light.'' Waste materials, typically ignored or excluded from conscious …
Exploring Staphylococcus Aureus Host-Pathogen Interaction Using Proteomic Technologies, Emilee Marlene Elizabeth Mustor
Exploring Staphylococcus Aureus Host-Pathogen Interaction Using Proteomic Technologies, Emilee Marlene Elizabeth Mustor
USF Tampa Graduate Theses and Dissertations
Staphylococcus aureus deploys an arsenal of virulence effectors to remodel the host environment during infection, while simultaneously the host mounts an immune response to contain and eliminate this bacterium. This dynamic interplay defines the host-pathogen interface and shapes infection outcome. In this context, the secreted proteases represent a major arm of S. aureus pathogenesis, promoting bacterial persistence in the host by dismantling immune defenses, cleaving host signaling molecules and reshaping the host proteome. However, traditional substrate-by-substrate characterization cannot reveal the full scope of proteolytic activity occurring during infection. To address this, we developed Terminal Amine-Guanidination of Substrates-Charge Reversal (TAGS-CR), a …
Early-Stage Corticostriatal Hyperactivity Impairs Cognitive Flexibility Alongside Striatal Cholinergic Dysfunction In An Alzheimer's Disease Model, Yufei Huang, Xueyi Xie, Zhenbo Huang, Ruifeng Chen, Himanshu Gangal, Xuehua Wang, Karienn Souza, Julia Hunter, Xin Wu, Doodipala Samba Reddy, Jeannie Chin, Jun Wang
Early-Stage Corticostriatal Hyperactivity Impairs Cognitive Flexibility Alongside Striatal Cholinergic Dysfunction In An Alzheimer's Disease Model, Yufei Huang, Xueyi Xie, Zhenbo Huang, Ruifeng Chen, Himanshu Gangal, Xuehua Wang, Karienn Souza, Julia Hunter, Xin Wu, Doodipala Samba Reddy, Jeannie Chin, Jun Wang
Faculty, Staff and Students Publications
Cognitive flexibility declines early in Alzheimer's disease, yet the underlying circuit mechanisms remain unknown. Here, we report that young 5xFAD mice exhibit deficits in instrumental reversal learning prior to spatial memory impairment. This behavioral inflexibility is associated with abnormal neuronal reactivation in the medial prefrontal cortex and dorsomedial striatum. Electrophysiological recordings reveal that medial prefrontal cortex neurons are hyperexcitable and receive increased excitatory input. Furthermore, glutamatergic transmission from the medial prefrontal cortex to striatal direct-pathway medium spiny neurons is enhanced and coincides with strengthened inhibitory transmission onto striatal cholinergic interneurons, reduced spontaneous firing, and diminished striatal acetylcholine release. Critically, sustained …
Human Milk Small Extracellular Vesicles Elicit Changes In Inflammatory Response In Infant Human Intestinal Enteroids, Kacie D Waiters, Anthony S Peidl, Hailey A Mcandrew, Ashfia F Khan, Grace Adeniyi-Ipadeola, Hephzibah Nwanosike, Sana Sharif, M Funmi Babajide, Micah Castillo, Preethi H Gunaratne, Samaneh Karami, Hoa Nguyen-Phuc, Xinli Liu, Sasirekha Ramani, Tasneem Bawa-Khalfe
Human Milk Small Extracellular Vesicles Elicit Changes In Inflammatory Response In Infant Human Intestinal Enteroids, Kacie D Waiters, Anthony S Peidl, Hailey A Mcandrew, Ashfia F Khan, Grace Adeniyi-Ipadeola, Hephzibah Nwanosike, Sana Sharif, M Funmi Babajide, Micah Castillo, Preethi H Gunaratne, Samaneh Karami, Hoa Nguyen-Phuc, Xinli Liu, Sasirekha Ramani, Tasneem Bawa-Khalfe
Faculty, Staff and Students Publications
Human milk (HM) is the key nutritional source for infants and the most effective preventative approach against serious gastrointestinal inflammatory diseases like necrotizing enterocolitis (NEC) in preterm infants. Numerous studies in animal models indicate HM-derived small extracellular vesicles (HMEV) reduce severity of inflammation; however, data on human-specific models are limited. Isolated HMEV were characterized from early-HM (colostrum and transitional), mature-HM, and a combined, pasteurized donor bank-like HM sample (pool-); pool-HMEV retains a profile aligned with HMEV from both early- and mature-HM samples. Exposure to pool-HMEV initiates unique gene signatures associated with reduction of inflammation including NFkB-driven TNFα signaling in human …
The Multitargeted Cellular Spectrum Of Quercetin: Ameliorating Xenobiotic Toxicities And Metabolic Disorders, Wissam Sajid Hashim
The Multitargeted Cellular Spectrum Of Quercetin: Ameliorating Xenobiotic Toxicities And Metabolic Disorders, Wissam Sajid Hashim
Muthanna Medical Journal
Quercetin, a prominent dietary flavonol, exhibits a diverse range of biological activities that extend beyond simple free-radical scavenging, encompassing vital cytoprotective, membrane-stabilizing, and metabolic-regulatory properties.1 This comprehensive review elucidates the multifaceted pharmacological spectrum of quercetin in restoring physiological homeostasis under conditions of xenobiotic insults and metabolic stress.2 Specifically, we synthesize experimental and clinical evidence—including pivotal comparative studies to demonstrate quercetin's exceptional capacity to regulate systemic lipid profiles, preserve hemorheological parameters, and maintain cellular membrane integrity across vital systems.3,4 Furthermore, this review highlights the therapeutic efficacy of quercetin in mitigating industrial and environmental xenobiotic-induced toxicities, with particular emphasis …
Molecular Identification Of Cryptococcus Albidus Isolated From A Gingivitis Infection In A Male From Karbala City, Iraq, Maysaa Taqi Al-Khazali, Zahraa Raheem Murshidy, Sarah Kadhim Al-Rahimy, Sura Abd Ali Kadhim Mohammed, Dhuha Ali Hussein
Molecular Identification Of Cryptococcus Albidus Isolated From A Gingivitis Infection In A Male From Karbala City, Iraq, Maysaa Taqi Al-Khazali, Zahraa Raheem Murshidy, Sarah Kadhim Al-Rahimy, Sura Abd Ali Kadhim Mohammed, Dhuha Ali Hussein
Karbala International Journal of Modern Science
The current study presents a case of gingivitis caused by Cryptococcus albidus in a 35-year-old male from the city of Karbala in Iraq. This fungal species was identified via morphology, microscopy, additionally to the VITEK system. C. albidus was further confirmed using the polymerase chain reaction (PCR) technique by amplifying the 18S rRNA gene as a universal primer and sequencing. Sequences analysis revealed that this strain of C. albidus had not been previously documented in the NCBI database. Hence, the newly obtained sequences were submitted to the GenBank repository and assigned the accession number OQ975882.1, marking the first report of …
The Shorthorn: October 29, 1982
The Shorthorn: October 29, 1982
The Shorthorn Newspaper Collection: 1980s
No abstract provided.
The Shorthorn: October 28, 1982
The Shorthorn: October 28, 1982
The Shorthorn Newspaper Collection: 1980s
No abstract provided.
The Shorthorn: October 27, 1982
The Shorthorn: October 27, 1982
The Shorthorn Newspaper Collection: 1980s
No abstract provided.
The Shorthorn: October 20, 1982
The Shorthorn: October 20, 1982
The Shorthorn Newspaper Collection: 1980s
No abstract provided.
The Shorthorn: October 15, 1982
The Shorthorn: October 15, 1982
The Shorthorn Newspaper Collection: 1980s
No abstract provided.
The Shorthorn: October 14, 1982
The Shorthorn: October 14, 1982
The Shorthorn Newspaper Collection: 1980s
No abstract provided.
The Shorthorn: October 13, 1982
The Shorthorn: October 13, 1982
The Shorthorn Newspaper Collection: 1980s
No abstract provided.
The Shorthorn: October 8, 1982
The Shorthorn: October 8, 1982
The Shorthorn Newspaper Collection: 1980s
No abstract provided.
The Shorthorn: October 6, 1982
The Shorthorn: October 6, 1982
The Shorthorn Newspaper Collection: 1980s
No abstract provided.
The Shorthorn: September 29, 1982
The Shorthorn: September 29, 1982
The Shorthorn Newspaper Collection: 1980s
No abstract provided.
The Shorthorn: September 24, 1982
The Shorthorn: September 24, 1982
The Shorthorn Newspaper Collection: 1980s
No abstract provided.
The Shorthorn: September 22, 1982
The Shorthorn: September 22, 1982
The Shorthorn Newspaper Collection: 1980s
No abstract provided.