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2026

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Establishment Of An In Vitro Dss-Induced Epithelial Injury Model To Investigate Il-6 Signaling And Microbial Metabolite Mediated Barrier Recovery, Srijal Kunwar Jan 2026

Establishment Of An In Vitro Dss-Induced Epithelial Injury Model To Investigate Il-6 Signaling And Microbial Metabolite Mediated Barrier Recovery, Srijal Kunwar

Graduate Studies Theses and Dissertations 2026

Dextran sodium sulphate (DSS) is widely used in vivo to induce epithelial injury; however, the molecular effects of DSS on intestinal epithelial cells, that investigate inflammatory and metabolic repair mechanisms remain unclear. Here, we establish an in vitro DSS-induced epithelial damage model using differentiated Caco-2 cell monolayer. Exposure to 2.5%(w/v) DSS for 24 hours resulted in significant upregulation of pore forming protein Claudin-2(2.677-fold) and oxidative marker, NOX-1(1.866-fold), accompanied by increased ROS production confirmed via DHE staining. Increased epithelial permeability was observed by TEER analysis, without significant cytotoxicity. Surprisingly, ELISA analysis revealed significant downregulation of IL-6 (p-value …


“I Call For The Resurgence And Reclamation Of Our Indigenous Ways”: Institutional Landscapes, Resistance, And The Experiences Of Mmir Advocates, Sara Tehrani Jan 2026

“I Call For The Resurgence And Reclamation Of Our Indigenous Ways”: Institutional Landscapes, Resistance, And The Experiences Of Mmir Advocates, Sara Tehrani

Graduate Studies Theses and Dissertations 2026

Indigenous Peoples across Turtle Island experience disproportionately high rates of violence and homicide compared to other racial groups. Rooted in coloniality and sustained by Western institutions, this epidemic is recognized as the Missing and Murdered Indigenous Relatives (MMIR) crisis. In response, Indigenous women have mobilized the MMIR Movement to raise awareness and advocate for institutional change. Although scholarship on MMIR has expanded, limited research has explored the experiences of MMIR advocates. This study interrogates the institutional landscapes that shape MMIR advocacy and explores the resistance strategies advocates employ to address the crisis. Using reflexive thematic analysis, this study examines semi-structured …


Nonpyrogenic "Black" Nitrogen Likely Plays A Major Yet Underrecognized Role In The Global Nitrogen Cycle, João Vitor Dos Santos, Aleksandar I. Goranov, Kyle M. Lambert, Theodoro Da Rosa Salles, Susan J. Carter, Ann Pearson, Patrick G. Hatcher Jan 2026

Nonpyrogenic "Black" Nitrogen Likely Plays A Major Yet Underrecognized Role In The Global Nitrogen Cycle, João Vitor Dos Santos, Aleksandar I. Goranov, Kyle M. Lambert, Theodoro Da Rosa Salles, Susan J. Carter, Ann Pearson, Patrick G. Hatcher

Chemistry & Biochemistry Faculty Publications

Condensed aromatic nitrogen (ConAN) is commonly found in soil and aquatic environments. ConAN is broadly viewed by the biogeochemistry community as a combustion-derived product leading to its frequent designation as pyrogenic “black” nitrogen. Here, we provide evidence that ConAN can also form through nonpyrogenic pathways. In an experiment simulating biomass oxidation, pine wood boards assembled with iron nails were exposed to 12 years of natural environmental conditions. Nitrogen concentrations increased from 0.2 to 1.2 wt % with increasing proximity to the nail. Ultrahigh resolution mass spectrometry showed enrichment of nitrogen-containing compounds within the lignin and condensed aromatic domains. X-ray spectroscopic …


Reconciliation, Draper Matthews Jan 2026

Reconciliation, Draper Matthews

Theses and Dissertations

This thesis exhibition, Reconciliation, examines how memory, loss, and lived experience shape personal identity over time. Through sculptural works composed of cast, blown, and hot-sculpted glass combined with mixed media, the exhibition explores the pressures that life events place upon individuals and the ways those pressures persist, transform, and become integrated into the self. The work considers identity not as a fixed state but as a continual process of negotiation between past experiences, present circumstances, and future possibilities.

Central to the project is the material analogy between glass and human experience. Glass, a material formed under extreme heat and pressure …


Freshman Record (Year Unknown), Bemidji State Unversity Jan 2026

Freshman Record (Year Unknown), Bemidji State Unversity

Freshman Record

No abstract provided.


Tooth Ablation And The Jōmon - Yayoi Transition In Japan, Laura R. Erickson Jan 2026

Tooth Ablation And The Jōmon - Yayoi Transition In Japan, Laura R. Erickson

Theses and Dissertations

The Jōmon – Yayoi period transition in Japan is marked by many migrants coming through the Korean Peninsula into Kyushu, sparking changes such as the introduction of wet-rice agriculture to the native hunter-gatherer-fisher Jōmon population and decreases in tooth ablation patterns and percentages. Ritual tooth ablation, or the removal of healthy front teeth, is typically seen as a coming-of-age practice, with the Jōmon having a diverse amount of ablation patterns. In this study, I explored how the rates and variation of tooth ablation changed throughout Japan after the arrival of Yayoi migrants from the continent. After calculating ablation rates per …


Turning 30 In 600 Feet, Tate Lewis-Carroll Jan 2026

Turning 30 In 600 Feet, Tate Lewis-Carroll

Theses and Dissertations

This thesis is a poem; it records fourteen consecutive months of the poet’s life through rigorous, daily typing habits with nonoptimal tools and material: a typewriter and 600 feet of receipt paper. Through the adoption of these conditions, and through the dailiness of the habit, this thesis crips and deploys a poetics of chronic impediment for accessing constraint and its role in making. This thesis includes a critical preface which explores some of the poet’s specific relationships to chronic pain, both physical and emotional; forgetfulness and dissociation; and disruption by remembering a decade-long flare of chronic illness and abuse. With …


Investigating Phosphorus Load Trends And Driving Factors In Illinois Watersheds Using Machine Learning Algorithms, Hannah Lartey Jan 2026

Investigating Phosphorus Load Trends And Driving Factors In Illinois Watersheds Using Machine Learning Algorithms, Hannah Lartey

Theses and Dissertations

Phosphorus (P) pollution in Illinois watersheds has become a significant water quality concern. Recent studies have shown increasing concentrations in streams and rivers, leading to eutrophication, which damages aquatic ecosystems and threatens human health. This study examines temporal trends in total phosphorus loads across 79 monitoring stations in Illinois from 1979 to 2020 and identifies the main environmental factors that influence P load variability. Trend analyses were conducted using the nonparametric Mann-Kendall and Sen’s slope methods. GIS-based climate, hydrology, and soil property datasets were assembled for each monitoring station. These datasets were used to build machine learning models using the …


Digitalisation In The Voluntary Sector: An Empirical Study On The Determinants Of It Acceptance, Deniz Dogu Jan 2026

Digitalisation In The Voluntary Sector: An Empirical Study On The Determinants Of It Acceptance, Deniz Dogu

School of Engineering, Computing and Mathematics Theses

Digitalisation represents a major societal trend that drives economic and social trans-formation by increasingly embedding digital information and communication techno-logies (ICT) into processes, interactions, and everyday activities across all domains of life. However, the voluntary sector has yet to fully embrace ICT. The extent to which volunteers integrate digital tools depends on factors such as technical infrastructure and willingness to adopt IT. Research in this area remains limited, and findings are often difficult to transfer across different national contexts. This PhD research addresses the gap in understanding IT acceptance in volunteering, using Germany as a case study. A comprehensive literature …


Mapping The Uk Commercial Fishing Network: A Knowledge-Based Framework For Sustainable Technology Adoption And Environmental Decision-Making, Matthew Prowse Jan 2026

Mapping The Uk Commercial Fishing Network: A Knowledge-Based Framework For Sustainable Technology Adoption And Environmental Decision-Making, Matthew Prowse

School of Engineering, Computing and Mathematics Theses

The UK commercial fishing industry operates within a complex web of stakeholders, technologies, and environmental pressures that challenge traditional approaches to sustainability and resource management. This research develops a comprehensive framework for understanding how technological advancement in UK fisheries creates unintended consequences that threaten long-term sustainability. Through a mixed-methods approach combining PESTLE analysis, grounded theory methodology, stakeholder mapping, case study investigation, this study introduces the "By-Product and Excess" theoretical framework to explain how fishing technologies generate two critical outcomes: by-products (undesirable environmental impacts such as CO₂ emissions, microplastics, and ecosystem damage) and excess (enhanced capacity to harvest beyond sustainable limits).The …


Implementing Bespoke Assistive Technologies: An Approach For Successful Introduction And Use Of Assistive Technology In Supported Living For Individuals With Intellectual Disabilities., Benjamin Morris Jan 2026

Implementing Bespoke Assistive Technologies: An Approach For Successful Introduction And Use Of Assistive Technology In Supported Living For Individuals With Intellectual Disabilities., Benjamin Morris

School of Health Professions Theses

Background: While the potential of assistive technologies for improving the lives of individuals with intellectual disabilities is well documented, successful implementation of these technologies is a complex challenge. Adoption-and-use-models of assistive technology are a key method to guide such adoption technology, however no specific model for supported living of those with intellectual-disability existed prior to this research. The research aimed to investigate how bespoke digital assistive technologies can be implemented in the supported living environment for people with intellectual disabilities. Three primary outputs were produced in order to address the research question. 1. A theoretical model that explains the barriers …


All Life As Witness: Developing A Mode Of Investigation Into Political Disappearance In 1960s Venezuela Reframed By Skinner Releasing Technique And Indigenous Knowledge, Livia Daza-Paris Jan 2026

All Life As Witness: Developing A Mode Of Investigation Into Political Disappearance In 1960s Venezuela Reframed By Skinner Releasing Technique And Indigenous Knowledge, Livia Daza-Paris

School of Art, Design and Architecture Theses

This practice-based research develops Ecologies of Poetic Forensics, an investigative mode for approaching political disappearance as a felt, ongoing condition that also reverberates across worlds beyond the human. Focused on my father's disappearance during Venezuela's 1960s revolutionary movement, the research follows relational dynamics within the personal, political, ecological ‘many worlds’ (Indígena Zapatistas 1996) shaped by state violence, including those of campesinos (land-based workers) in Cocorote, Lara State. The inquiry unfolds across Venezuela, Canada, and the United States, tracing territory that exceeds state borders.

The research brings the Skinner Releasing Technique, a movement practice oriented by poetic imagery and embodied …


Type Ii Diabetes Treatment Comparison Via Compartment Modeling, Abigail M. Collins Jan 2026

Type Ii Diabetes Treatment Comparison Via Compartment Modeling, Abigail M. Collins

Theses and Dissertations

Type II diabetes mellitus affects one in ten adults worldwide, yet the effects of treatment type and adherence level on developing complications and quality of life have not been well characterized at the population level, and mathematical modeling offers a structured way to examine these dynamics. This thesis adapts the Boutayeb et al. (2004) model to incorporate dynamic treatment types and levels of adherence, producing nine scenarios in which complication development rate and complication recovery rate differed, to compare peak complications and quality of life across treatment and adherence conditions. Using a system of ordinary differential equations and compartment modeling, …


Framing Belonging And Exclusion: A Dialogic Narrative Analysis Of English- And Spanish-Language Immigration Coverage During The Trump 2024 Presidential Election, Evangeline T. Cruz Jan 2026

Framing Belonging And Exclusion: A Dialogic Narrative Analysis Of English- And Spanish-Language Immigration Coverage During The Trump 2024 Presidential Election, Evangeline T. Cruz

Theses and Dissertations

I investigated how English- and Spanish-language news outlets narratively constructed Latinx immigrants during the Trump 2024 presidential campaign, a period marked by heightened anti-immigrant rhetoric and political volatility. While past scholarships examined immigration framing through tone, sentiment, or frequency analysis, limited attention has been given to the deeper narrative structures that shape public meaning-making. This study addresses this gap by applying Dialogic Narrative Analysis (DNA) and Critical Thematic Analysis (CTA) to a bilingual dataset of 120 newspaper articles from The New York Times, Los Angeles Times, El Diario, and La Opinión published between November 2024 and February 2025.

Findings reveal …


Secret-Keeping Experiences Of Young Adults, Jace C. Griffith Jan 2026

Secret-Keeping Experiences Of Young Adults, Jace C. Griffith

Theses and Dissertations

In 2020, researchers Frijns et al. called for a new wave of secret-keeping research which prioritized the person-centric experience of youth keeping secrets. This study added to that collection by comparing two kinds of secret-keeping which are not compared in existing research: secrets which are related to abuse, and secrets which are not. Researchers in the field of child welfare study only abuse-related secret-keeping, almost always qualitatively. Alternatively, researchers of non-abuse secret-keeping or general secret-keeping collect almost entirely quantitative data, absent of the personal experience of secret-keeping.

Through an online survey, 205 undergraduate students were asked to reflect on an …


Effects Of Compost Incorporated Versus Surface Applied On Soybean Yield And Soil Health, Maheshwari Kuchanapally Jan 2026

Effects Of Compost Incorporated Versus Surface Applied On Soybean Yield And Soil Health, Maheshwari Kuchanapally

Theses and Dissertations

Compost application is increasingly recognized as a sustainable soil management practice that enhances soil health and crop production. However, the method of application, incorporated versus surface applied, may influence its effectiveness in improving soil properties and crop productivity. This study evaluated the effects of compost application method on soybean (Glycine max L. Merr.) yield and soil health at Illinois State University Research Farm in Lexington, Illinois, across two growing seasons, 2024 and 2025. The 2024 experiment used a Completely Randomized Design comparing incorporated versus surface-applied compost (n = 4; 8 plots). The 2025 experiment used a Randomized Complete Block Design …


Social Media, Masculine Body Ideals, And The Drive For Muscularity: A Serial Mediation Model Across Sexual Identities, Sean P. Mcdaniel Jan 2026

Social Media, Masculine Body Ideals, And The Drive For Muscularity: A Serial Mediation Model Across Sexual Identities, Sean P. Mcdaniel

Theses and Dissertations

Body image concerns among men are increasingly prevalent yet remain understudied compared to women’s experiences. Drawing on objectification theory, the present study examines the relationship between social media influence and men’s drive for muscularity through a serial mediation model. Specifically, the present study investigates whether the internalization of masculine body ideals and engagement in body surveillance behaviors mediate the link between social media influence and the drive for muscularity. Furthermore, the present study model attempts to explore how these processes differ across sexual identities, given evidence that sexual minority men face distinct sociocultural pressures regarding appearance. Adult male-identifying social media …


Middle School Students' Initial Ideas And Their Connections In Proportion Word Problems, Carrie Ann Lawton Jan 2026

Middle School Students' Initial Ideas And Their Connections In Proportion Word Problems, Carrie Ann Lawton

Theses and Dissertations

In this dissertation study, I sought to identify the initial ideas that middle school students had when approaching Multiple Batches and Variable Parts proportion word problems, as well as the connections they made among those initial ideas. I conducted semi-structured individual and paired interviews with 13 sixth- and seventh-grade students at the end of their school year. I then used the Knowledge-in-Pieces theoretical perspective to identify knowledge resources that the participants accessed when approaching the tasks, prior to any intervention on my part.

Through my analysis, I identified 18 initial ideas that the middle school students employed when solving the …


The Effects Of A Work-Strengths Affirmation Intervention On Death Anxiety: Meaning And Self-Esteem As Mediators, Begüm Orhan Jan 2026

The Effects Of A Work-Strengths Affirmation Intervention On Death Anxiety: Meaning And Self-Esteem As Mediators, Begüm Orhan

Theses and Dissertations

Death anxiety is a transdiagnostic construct and a universally experienced existential fear that has been linked to a wide range of psychological difficulties, including anxiety, depression, and impaired well-being. Despite its widespread impact, empirical research on targeted interventions for death anxiety remains limited. The present study aimed to address this gap by developing and evaluating an online, single-session, theory-based (i.e., Terror Management Theory, positive psychology) intervention focused on affirming personal strengths in the context of one's work. The intervention was designed to target work-strengths (i.e., leadership, adaptability)—an intersection of positive and vocational psychology.

College students from a large Midwestern university …


Why Make Books In Art Class Or Art In Reading Class? How Storytelling Impacts Youth Literacy And Cultural Dialogue, Holly Lewis Jan 2026

Why Make Books In Art Class Or Art In Reading Class? How Storytelling Impacts Youth Literacy And Cultural Dialogue, Holly Lewis

Theses and Dissertations

Given complex factors affecting reading literacy and students’ need for empowerment through creativity, this thesis project will investigate possibilities for combining artmaking with written narrative. Creative solutions, such as integrated and project-based learning activities, are documented as having some of the best positive impacts on overall learning growth (Laur, 2021; Aydin & Mutlu, 2023). Therefore, my thesis includes a discussion on Arts Integration initiatives and an illustrated book for students ages 10-15, which can be used as an example for their own studies into personal narrative. While the research presented here touches on multiple factors affecting students’ self-esteem and willingness …


Children’S And Adult Perspectives On Mental Health In Children’S Youth Literature And Media, Edcel J. Cintron-Gonzalez Jan 2026

Children’S And Adult Perspectives On Mental Health In Children’S Youth Literature And Media, Edcel J. Cintron-Gonzalez

Theses and Dissertations

My dissertation extends existing work on mental health in children’s literature to examine the different narratives strategies that text, film, and media for young audiences use to connect childhood, caregiving, and emotional wellbeing. Three areas of scholarship—children’s literature scholarship, health humanities work, and feminist care ethics—inform my project. Overall, I am interested in how a variety of genres for young readers represent mental health not only as an individual experience, but also as something shaped by family, culture, community, and adult-child relationships. It is therefore important to delineate the different concepts and frameworks that help make sense of how mental …


Interaction Of The Gram-Positive Human Pathogen Staphylococcus Aureus With Host Lipids, Sharanya Paul Jan 2026

Interaction Of The Gram-Positive Human Pathogen Staphylococcus Aureus With Host Lipids, Sharanya Paul

Theses and Dissertations

Staphylococcus aureus is a prominent pathogen that is known to incorporate straight-chain unsaturated fatty acids (SCUFAs) into its lipids in addition to the normally biosynthesized branched-chain fatty acids (BCFAs) and straight-chain fatty acids (SCFAs). Furthermore, it has recently been shown that the incorporation of oleic acid into S. aureus lipids significantly enhanced the growth of the organism at low temperatures due to the greater fluidity imparted to the membrane. Together with others in the Wilkinson and Dahl laboratory, I have shown that low-temperature growth is enhanced by various SCUFAs, including the human antimicrobial fatty acids sapienic acid, linoleic acid, and …


Digital Truth Making, Creative Resistance, And Power Negotiation Through Social Media: A Digital Ethnography Of The 2024 Gen Z Uprising In Bangladesh, Mustafizurrrahman Rahat Jan 2026

Digital Truth Making, Creative Resistance, And Power Negotiation Through Social Media: A Digital Ethnography Of The 2024 Gen Z Uprising In Bangladesh, Mustafizurrrahman Rahat

Theses and Dissertations

This research investigates how social media shaped political participation during the 2024 July Uprising in Bangladesh, focusing on the production and negotiation of political truth, legitimacy, and resistance through everyday digital practices. Rather than conceptualizing social media solely as a communication tool, the study analyzes digital platforms as contested spaces where activists, state-aligned actors, and other participants constructed, circulated, and challenged competing political narratives throughout the uprising.

Drawing on digital ethnography, this study integrates netnographic observation of Facebook groups, pages, hashtags, memes, and protest-related visual content with content analysis, reflexive participant observation, and semi-structured interviews with Generation Z participants. The …


The Effect Of Sex On The Signal Transmission Of Duetting Bay Wrens, Rachel C. Schinzler Jan 2026

The Effect Of Sex On The Signal Transmission Of Duetting Bay Wrens, Rachel C. Schinzler

Theses and Dissertations

During communication, senders send signals for their benefit to elicit a behavioral response from a receiver. Acoustic signals are efficient for long-distance signaling; however, they are influenced by environmental features, such as foliage density, humidity, temperature, and time of day. Individuals can overcome these challenges by using signals with a trajectory of peak frequency, frequencies, volumes, and timing best suited to signal transmission in their environment. Signal transmission has been studied at the species level; however, not much is known about sex differences within the same species. Duetting species provide a useful system for examining sex-specific challenges in transmission, as …


Monitoring Shifts In Estuarine Microbial Communities: A Dna-Metabarcoding Approach, Ashley M. Reaume Jan 2026

Monitoring Shifts In Estuarine Microbial Communities: A Dna-Metabarcoding Approach, Ashley M. Reaume

Graduate Studies Theses and Dissertations 2026

Estuarine microbial communities, including plankton, algae, and bacteria, play important roles in nutrient cycling and food web structure. They are sensitive to changes in abiotic conditions, and shifts in community composition can provide insight into estuarine ecosystem functioning in the face of various physiochemical and anthropogenic stressors. Therefore, monitoring these communities is essential for understanding and maintaining estuarine health. DNA metabarcoding is an emerging technique for enhancing biological monitoring, allowing for the detection of multiple species within a single sample. This dissertation first focuses on how methodological decisions impact DNA metabarcoding results and then implements these optimized methods to perform …


Mapping Functional Connectivity In The Pigeon Brain With Wide-Field Optical Imaging, Kathryn C Chenard, Annie R Bice, Seana H Bice, Joseph P Culver, Paula Gerliz, Xavier Helluy, Onur Güntürkün, Jason W Trobaugh, Mehdi Behroozi, Carlos A Botero Jan 2026

Mapping Functional Connectivity In The Pigeon Brain With Wide-Field Optical Imaging, Kathryn C Chenard, Annie R Bice, Seana H Bice, Joseph P Culver, Paula Gerliz, Xavier Helluy, Onur Güntürkün, Jason W Trobaugh, Mehdi Behroozi, Carlos A Botero

2020-Current year OA Pubs

SIGNIFICANCE: Adapting optical imaging technology to avian models can overcome many limitations imposed by functional magnetic resonance imaging (fMRI), which currently restricts the number of species used to study functional connectivity. Developing advanced technology to expand the diversity of species that can be effectively imaged is crucial for addressing significant questions that are currently unreachable, such as understanding the evolution of cognition from a comparative perspective.

AIM: We assessed the potential of optical imaging technology to measure functional connectivity in birds, utilizing pigeons as an avian model. We evaluated whether we could partition the dorsal surface of the pigeon brain …


Investigating The Potential Utilisation Of Black Soldier Fly (Hermetia Illucens) As An Alternative Protein Source In Tilapia And Carp Feed, Sahya Maulu Jan 2026

Investigating The Potential Utilisation Of Black Soldier Fly (Hermetia Illucens) As An Alternative Protein Source In Tilapia And Carp Feed, Sahya Maulu

School of Biological and Marine Sciences Theses

Three experimental trials were conducted to evaluate defatted black soldier fly (BSF; Hermetia illucens) larvae meal and BSF frass as alternative protein ingredients. Defatted BSF larvae meal was tested in diets for both Nile tilapia (Oreochromis niloticus) and mirror carp (Cyprinus carpio), whereas BSF frass was assessed only in Nile tilapia.In the first experiment, dietary inclusion of 20% and 40% BSF meal, replacing mainly soybean meal (SBM) and corn gluten meal (CGM), was evaluated in Nile tilapia over 5 weeks. BSF improved growth and feed utilisation in a dose-dependent manner, increased posterior intestinal fold length, muscularis thickness, and goblet cell …


Coping With Climate Change: The Role Of Plasticity Within And Across Generations, Caitlin Mcandry Jan 2026

Coping With Climate Change: The Role Of Plasticity Within And Across Generations, Caitlin Mcandry

School of Biological and Marine Sciences Theses

Climate change is leading to increased mean temperatures and more frequent and severe temperature anomalies, threatening organisms globally. Phenotypic plasticity, the ability of a given genotype to express different phenotypes in different environments, may offer a mechanism that allows organisms to temporarily persist in a rapidly changing environment, ultimately buying time for genetically based adaptations to evolve. Plasticity has been demonstrated both within and across generations, in response to different environmental stressors. However, our understanding of the interactive effects of plastic responses across levels of biological organisation, and over temporal scales from hours to generations, is still limited. Additionally, we …


Crustacean Sensation: Intraspecific Sensory Diversity And Patterns Of Information Acquisition And Use Of An Intertidal Malacostracan, Ari Drummond Jan 2026

Crustacean Sensation: Intraspecific Sensory Diversity And Patterns Of Information Acquisition And Use Of An Intertidal Malacostracan, Ari Drummond

School of Biological and Marine Sciences Theses

The following thesis examines intraspecific sensory diversity in the common hermit crab, Pagurus bernhardus (Plate 1), a tractable Malacostracan model for research in sensory biology and information ecology. By examining variation in sensory morphology and behaviour across two sensory appendages: the chelipeds (chemo-mechanosensory) and the antennules (chemosensory), this work demonstrates how interdisciplinary approaches can elucidate how organisms gather and use information and the structural variation necessary to do so. It further considers the potential fitness consequences of intraspecific sensory diversity (Chapter 1). A discussion of two sources of intraspecific sensory variation—body asymmetry and sexual dimorphism of chelar tissue—and the functional …


Coordinated Regulation Of Capping Protein By Carmil And V-1/Myotrophin, John A Hammer, John A Cooper Jan 2026

Coordinated Regulation Of Capping Protein By Carmil And V-1/Myotrophin, John A Hammer, John A Cooper

2020-Current year OA Pubs

Capping Protein (CP) plays a central role in controlling actin filament dynamics in almost all eukaryotic cell types by virtue of its ability to block monomer addition and loss at the barbed end of the actin filament. Like other proteins that control actin assembly, CP is subject to regulation. Here we focus on two direct regulators of CP-CARMIL and V-1/Myotrophin. Specifically, we review recent biochemical, structural, imaging, and cell biological data that argue these two proteins cooperate to create a regulatory cycle for CP that controls its availability, activity, and site of action in the cell. Finally, we discuss unresolved …