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2026

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Immortalization And Characterization Of Schwann Cell Lines Derived From Nf1-Associated Cutaneous Neurofibromas, Hua Li, Angela Hirbe, Et Al. Jan 2026

Immortalization And Characterization Of Schwann Cell Lines Derived From Nf1-Associated Cutaneous Neurofibromas, Hua Li, Angela Hirbe, Et Al.

2020-Current year OA Pubs

Neurofibromatosis type 1 (NF1) is an autosomal dominant condition in which patients are heterozygous for a disruptive pathogenic variant in the NF1 gene. The most characteristic feature of the condition NF1 is the neurofibroma, a benign, multi-cellular tumor which initiates when a cell of the Schwann cell lineage gains a somatic pathogenic variant of the other NF1 allele. Neurofibromas developing at nerve termini in the skin are termed "cutaneous" neurofibromas (cNFs), while those developing within larger nerves are termed "plexiform." Most patients develop cNFs beginning in late childhood or early adulthood, continuing throughout life at variable rates. Some patients may …

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Dysregulated Lactate Metabolism Synergizes With Als Genetic Risk Factors To Accelerate Motor Decline, Shweta Tendulkar, Tong Wu, Amy Strickland, Amber R. Hackett, Yurie Sato-Yamada, Xianrong Mao, Yo Sasaki, Jeffrey Milbrandt, A. Joseph Bloom, Aaron Diantonio Jan 2026

Dysregulated Lactate Metabolism Synergizes With Als Genetic Risk Factors To Accelerate Motor Decline, Shweta Tendulkar, Tong Wu, Amy Strickland, Amber R. Hackett, Yurie Sato-Yamada, Xianrong Mao, Yo Sasaki, Jeffrey Milbrandt, A. Joseph Bloom, Aaron Diantonio

2020-Current year OA Pubs

Neurons rely on glial 'lactate shuttling' for metabolic support, which declines with aging and in neurodegenerative disease. Full disruption of lactate shuttling in peripheral nerves causes progressive axon degeneration, but we were interested to understand how partial disruption, a scenario more relevant to aging and disease, contributes to neurodegeneration risk. Pyruvate and lactate are interconverted by lactate dehydrogenases (LDHA and LDHB) in both lactate producing and consuming cells. We therefore began by investigating Ldhb knockout mice (loss of LDHA, the dominant LDH in liver and muscle, caused embryonic lethality), and discovered that they develop progressive neuromuscular junction atrophy and functional …

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Chronic Oral Cannabidiol Delays Seizure Onset And Reduces Seizure Burden In A Mouse Model Of Cln2 Disease, Joshua T. Dearborn, Keigo Takahashi, Nicholas R. Rensing, Michael Wong, Jonathan D. Cooper, Mark S. Sands Jan 2026

Chronic Oral Cannabidiol Delays Seizure Onset And Reduces Seizure Burden In A Mouse Model Of Cln2 Disease, Joshua T. Dearborn, Keigo Takahashi, Nicholas R. Rensing, Michael Wong, Jonathan D. Cooper, Mark S. Sands

2020-Current year OA Pubs

A growing body of literature describes the anti-inflammatory, neuroprotective, and anti-epileptic properties of the cannabis sativa constituent cannabidiol, suggesting that it might play a useful role in the treatment of neurodegenerative diseases. Late infantile neuronal ceroid lipofuscinosis (CLN2 disease) is a rare pediatric neurodegenerative disorder resulting from an inherited dysfunction of the lysosome. CLN2 disease, and its representative animal models, display neuroimmune response, neuroinflammation, neurodegeneration, and epileptic seizures, and these symptoms are all touted as potential targets of cannabidiol therapeutic benefit. Here, we treated a valid model of CLN2 disease with long-term daily cannabidiol (300 mg/kg) from 1 month of …

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Designing An Interactive Digital Storytelling Tool To Enhance Key Stage 3 English Literacy: A Design-Based Research Study, Byung Jae Park Jan 2026

Designing An Interactive Digital Storytelling Tool To Enhance Key Stage 3 English Literacy: A Design-Based Research Study, Byung Jae Park

School of Law, Humanities and Social Sciences Theses

Although digital storytelling has transformative potential for language learning, its integration into Key Stage 3 (KS3) education remains unexplored. This thesis explores this topic by developing and evaluating an Interactive Storybook prototype designed for 11–14-year-old learners in a UK educational context.Using an interdisciplinary methodology that combines design-based research, the Delphi approach and constructivist grounded theory, this study involved three groups of experts – academic experts, practising educators and EdTech professionals – across three iterative development cycles. While the prototype was designed specifically for Key Stage 3 learners, the study employed a design appraisal approach instead of classroom piloting, with learner …

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Investigating The Determinants Of Fight Dynamics In The Minotaur Beetle Typhaeus Typhoeus, Amy Bromley Jan 2026

Investigating The Determinants Of Fight Dynamics In The Minotaur Beetle Typhaeus Typhoeus, Amy Bromley

School of Biological and Marine Sciences Theses

It is widely accepted that the main determinants of contest outcome are resource value, residency status, and resource holding potential, with each of these playing an important role in determining contest behaviour. Examples of resource holding potential are morphological traits such as body size and weaponry. Animals that possess weaponry can exhibit different morphotypes, such as size difference in horns, which can lead to differences in contest behaviour, with larger morphotypes engaging in head-to-head combat, while smaller morphotypes can avoid combat altogether. One such species that possess weapons in the form of horns and engages in physical combat, is the …

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Investigating The Potential Utilisation Of Black Soldier Fly (Hermetia Illucens) As An Alternative Protein Source In Tilapia And Carp Feed, Sahya Maulu Jan 2026

Investigating The Potential Utilisation Of Black Soldier Fly (Hermetia Illucens) As An Alternative Protein Source In Tilapia And Carp Feed, Sahya Maulu

School of Biological and Marine Sciences Theses

Three experimental trials were conducted to evaluate defatted black soldier fly (BSF; Hermetia illucens) larvae meal and BSF frass as alternative protein ingredients. Defatted BSF larvae meal was tested in diets for both Nile tilapia (Oreochromis niloticus) and mirror carp (Cyprinus carpio), whereas BSF frass was assessed only in Nile tilapia.In the first experiment, dietary inclusion of 20% and 40% BSF meal, replacing mainly soybean meal (SBM) and corn gluten meal (CGM), was evaluated in Nile tilapia over 5 weeks. BSF improved growth and feed utilisation in a dose-dependent manner, increased posterior intestinal fold length, muscularis thickness, and goblet cell …

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Assessing The Ecological Vulnerability Of Natural Flood Defences And Risks To Agricultural Land Following Seawater Flooding, Cally Barratt Jan 2026

Assessing The Ecological Vulnerability Of Natural Flood Defences And Risks To Agricultural Land Following Seawater Flooding, Cally Barratt

School of Biological and Marine Sciences Theses

Anthropogenic climate change is intensifying extreme weather events, affecting the natural environment by altering ecosystems, and leading to habitat loss. Pressingly, the frequency and severity of storm surge flooding in low-lying coastal regions is projected to increase under future climate scenarios. There is a growing need to understand how these events will impact coastal ecosystems, and the measures that can be taken to mitigate against these effects and protect natural resources. Furthermore, with increased pressures placed on agriculture to meet food demand, protecting arable land resources in coastal regions from the rising threat of flooding is imperative. This thesis explores …

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Influence Of Ecological Transitions On The Evolution Of Circadian And Light Detection Genes In Squamates, Isobel Sleep Jan 2026

Influence Of Ecological Transitions On The Evolution Of Circadian And Light Detection Genes In Squamates, Isobel Sleep

School of Biological and Marine Sciences Theses

Circadian rhythms are self-sustaining, endogenous processes that align behaviour and physiology with daily environmental cycles. Rhythms are regulated by conserved genes forming transcriptional feedback loops and are entrained by environmental cues (e.g., light). Circadian systems are well studied in model organisms, their molecular evolution in squamates (lizards and snakes) remains less understood. Squamates represent the most species-rich reptile group with extensive ecological and sensory diversity, exhibiting multiple independent transitions across ecological niches, including repeated shifts into low-light environments (e.g., nocturnality, fossoriality), making them ideal for examining circadian and light-associated gene evolution. This study investigates how ecological transitions have influenced the …

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Coping With Climate Change: The Role Of Plasticity Within And Across Generations, Caitlin Mcandry Jan 2026

Coping With Climate Change: The Role Of Plasticity Within And Across Generations, Caitlin Mcandry

School of Biological and Marine Sciences Theses

Climate change is leading to increased mean temperatures and more frequent and severe temperature anomalies, threatening organisms globally. Phenotypic plasticity, the ability of a given genotype to express different phenotypes in different environments, may offer a mechanism that allows organisms to temporarily persist in a rapidly changing environment, ultimately buying time for genetically based adaptations to evolve. Plasticity has been demonstrated both within and across generations, in response to different environmental stressors. However, our understanding of the interactive effects of plastic responses across levels of biological organisation, and over temporal scales from hours to generations, is still limited. Additionally, we …

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Trialing A Novel Method Of Skin Mucus Sampling To Measure Stress And Reproductive Steroid Hormones In Mobula Species Mobula Alfredi And Mobula Munkiana, Bethany Faulkner Jan 2026

Trialing A Novel Method Of Skin Mucus Sampling To Measure Stress And Reproductive Steroid Hormones In Mobula Species Mobula Alfredi And Mobula Munkiana, Bethany Faulkner

School of Biological and Marine Sciences Theses

Anthropogenic pressures, exacerbated by exceptionally slow population growth, have led to all mobulid species being listed on the IUCN Red List. Understanding stress and reproductive physiology is essential for improving mobulid conservation strategies. However, few studies have investigated the hormonal processes that underlie stress responses and reproductive physiology in mobulids. Studies on fish species have identified positive correlations between steroid hormone concentrations in blood and skin mucus, the collection of the latter being a much less invasive technique. This pilot study examined the feasibility of using skin mucus as a non-invasive matrix for detecting steroid hormones in two mobulid species. …

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