Digital Commons Network^™

Therapeutic Potential Of Hookworm Proteins In Promoting Regulatory Immune Responses To Modulate Trypanosoma Cruzi Induced Liver Inflammation And Oxidative Stress, Maria Jose Villar, Cristina Poveda, Bin Zhan, Maya Gonsoulin, Kathryn M Jones

Faculty, Staff and Students Publications

Background: Chronic Trypanosoma cruzi infection causes significant liver pathology, and current antiparasitic treatments often worsen hepatic damage. Hookworm-derived proteins have shown immunomodulatory effects in inflammatory diseases, including T. cruzi-induced myocarditis.

Objective: This study evaluates recombinant hookworm proteins AIP-1 and AIP-2 for treating liver inflammation in a murine model of chronic Chagas disease (CD).

Methods: Female BALB/c mice infected with T. cruzi were treated with AIP-1 or AIP-2 (1 mg/kg) for seven days. Controls were untreated or received aspirin (25 mg/kg) for 14 days. Liver tissues were analyzed for parasite burden (quantitative polymerase chain reaction - qPCR), histopathology (H&E, Picrosirius Red), …

Platelet Extravasation In The Microvasculature: An Under-Appreciated Role For Platelets, Justin A Courson, Vahid Afshar-Kharghan, Alan R Burns, Rolando E Rumbaut

Faculty, Staff and Students Publications

In recent years, evidence has accumulated highlighting the presence and role of platelet extravasation - wherein platelets accumulate in tissue parenchyma - at a variety of sites throughout the body. While platelets are traditionally known for their roles in hemostasis and thrombosis, it is evident that platelets are potent mediators of inflammation across an array of physiological and pathological contexts. While anucleate and small in size, platelets contain a rich diversity of molecules in their granules capable of modulating cell proliferation, tissue repair, and a host of immune responses. There is growing evidence that platelet extravasation out of the vascular …

Ptpn1 Regulation Via Ybx1-Ptbp1 Interaction Promotes Fibroblast Activation And Fibrotic Remodeling In The Lung, Huibing Liu, Cong Xia, Yingying Zhang, Yulong Gan, Lianhui Cheng, Xuqian Wang, Airu Chang, Wenyu Zhao, Bin Li, Yaxuan Wang, Yajun Li, Ivan Rosas, Juntang Yang, Guoying Yu, Lan Wang

Faculty, Staff and Students Publications

Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive interstitial pneumonia of unknown etiology. Its pathogenesis involves complex multicellular interactions and signaling pathways, with fibroblast-to-myofibroblast transition (FMT) being critical for fibrogenesis. Although the transcription factor Y-box binding protein 1 (YBX1) regulates processes such as cell proliferation, transcription, translation, and DNA repair, its role in IPF remains undefined. Here, we demonstrate that YBX1 overexpression significantly promotes transforming growth factor-β1 (TGF-β1)-induced pulmonary FMT, leading to substantially increased extracellular matrix (ECM) deposition in primary human (PHLFs) and mouse (PMLFs) lung fibroblasts. Conversely, YBX1 inhibition markedly suppresses TGF-β1-driven aberrant fibroblast migration and activation. Mechanistically, YBX1 …

Commencement Program 2026, Loma Linda University

Commencement Programs

CONTENTS

1 | Message from the President

3 | 2026 Events of Commencement

5 | The Academic Procession

6 | Institutional Administration

7 | Board of Trustees

8 | Significance of Academic Regalia

9 | University History Highlights

11 | Loma Linda University Health and Loma Linda University Honorees

The Programs, The School Honorees, and The Speakers

24 | School of Medicine

43 | School of Pharmacy

54 | School of Dentistry

72 | School of Public Health

85 | San Manuel Gateway College

91 | School of Allied Health Professions — Allied Health Studies, Cardiopulmonary Sciences, Clinical Laboratory Science, …

Cerebellar Deep Brain Stimulation Rescues Purkinje Cell Mitochondrial Density In A Genetic Mouse Model Of Cerebellar Ataxia, Lauren N Miterko-Myers, Lauren E Peacoe, Lita Duraine, Zhongyuan Zuo, Roy V Sillitoe

Faculty, Staff and Students Publications

Deep brain stimulation (DBS) improves motor function in a growing list of movement diseases including Parkinson's disease, dystonia, and tremor. There is evidence that DBS may also be effective in ataxia. It is not known why DBS is effective, but modulating cell activity and conferring neuroprotection are hypothesized to underlie its benefits. Understanding the effects of DBS on neurons is paramount to extending its clinical use in the treatment of various motor and non-motor diseases. Here, we stimulated the cerebellum of Car8 waddles (Car8wdl) mice, given the cerebellum's important role in ataxia pathophysiology. Using transmission electron microscopy, we tested the …

Eligibility For Anti-Amyloid Treatment In A Multiethnic Community-Based Study, Lydia Trudel, Joseph Therriault, Arthur C Macedo, Karin L Meeker, Meredith N Braskie, Arthur W Toga, Serge Gauthier, Paolo Vitali, Suzanne E Schindler, Sid E O'Bryant, Pedro Rosa-Neto

2020-Current year OA Pubs

INTRODUCTION: The approval of anti-amyloid monoclonal antibodies (mAbs), including lecanemab and donanemab, represents a significant advance in disease-modifying therapies (DMTs) for early Alzheimer's disease (AD). While appropriate use recommendations (AURs) have been established to guide clinical decision-making, the proportion of individuals with cognitive impairment in real-world, multiethnic populations meeting eligibility criteria remains unknown, as do potential differences in treatment-related risks across ethnic groups.

METHODS: We included 513 cognitively impaired individuals from the Health and Aging Brain Study-Health Disparities study, a multiethnic community-based cohort. Eligibility for lecanemab and donanemab was determined using published AUR criteria. Counts of amyloid-related imaging abnormalities were …

Thinking Machines: Cybernetics, Artificial Intelligence, And Technological Anxiety In The American Cold War, Erin Mae Wilcox

Theses and Dissertations

Following the Second World War, cybernetics emerged as a cross-disciplinary study in philosophy, neurophysiology, electrical engineering, and mathematics. Cyberneticists proposed the formal study of the man-machine analogy; that is, to equate biological structures to a complex mechanical system. Drawing from this analogy, cyberneticists used programmable digital computers to emulate the functions of the human brain. The study of artificial intelligence emerged within this cybernetic discourse in the early 1950s; yet, by the mid-1960s, the two disciplines suffered a methodological fracture. Drawing from a tradition generated by this fracture, historians have traditionally examined cybernetics and artificial intelligence in isolation from one …

Cover Crop Effects On Soil Porewater Nutrients And Hydrothermal Properties, Md Mahadi Hasan

Theses and Dissertations

Adoption of winter cover crops in the U.S. Midwest may reduce nitrogen (N) and phosphorus (P) leaching from soils, potentially shrinking the hypoxic zone by limiting nutrient runoff into the Gulf of Mexico. To evaluate the impact of selected winter cover crops on soil porewater N and P concentration, a field study was conducted at the Illinois State University Research Farm (ISURF) and the Western Illinois University Research Farm (WIURF). The experimental design was a block experiment with four replications.  Cover crop treatments included a winter fallow, wild pennycress (WPC), golden pennycress (GPC), cereal rye (CR), annual ryegrass (AR), and …

Framing Belonging And Exclusion: A Dialogic Narrative Analysis Of English- And Spanish-Language Immigration Coverage During The Trump 2024 Presidential Election, Evangeline T. Cruz

Theses and Dissertations

I investigated how English- and Spanish-language news outlets narratively constructed Latinx immigrants during the Trump 2024 presidential campaign, a period marked by heightened anti-immigrant rhetoric and political volatility. While past scholarships examined immigration framing through tone, sentiment, or frequency analysis, limited attention has been given to the deeper narrative structures that shape public meaning-making. This study addresses this gap by applying Dialogic Narrative Analysis (DNA) and Critical Thematic Analysis (CTA) to a bilingual dataset of 120 newspaper articles from The New York Times, Los Angeles Times, El Diario, and La Opinión published between November 2024 and February 2025.

Findings reveal …

Secret-Keeping Experiences Of Young Adults, Jace C. Griffith

Theses and Dissertations

In 2020, researchers Frijns et al. called for a new wave of secret-keeping research which prioritized the person-centric experience of youth keeping secrets. This study added to that collection by comparing two kinds of secret-keeping which are not compared in existing research: secrets which are related to abuse, and secrets which are not. Researchers in the field of child welfare study only abuse-related secret-keeping, almost always qualitatively. Alternatively, researchers of non-abuse secret-keeping or general secret-keeping collect almost entirely quantitative data, absent of the personal experience of secret-keeping.

Through an online survey, 205 undergraduate students were asked to reflect on an …

Bovine Lactoferrin Maintains Antibacterial Effect Against Neonatal Escherichia Coli Septicaemia Isolates Despite The Presence Of Iron Acquisition Genes, Matthew Mayorga, Joshua L. Wheatley, Brianna N. Maldonado, Susana Chavez-Bueno

Student Publications

Introduction. Escherichia coli is a dominant cause of neonatal sepsis for which no prevention measures currently exist. Lactoferrin (LF) is an iron-sequestering antibacterial protein that has been noticed to decrease neonatal late-onset sepsis.

Hypothesis/Gap Statement. LF’s effect on in vitro growth of neonatal E. coli clinical isolates causing septicaemia is unknown. The prevalence of iron acquisition virulence genes which contribute to pathogenicity outcomes in these strains has also not been described in detail.

Aim. To evaluate bovine lactoferrin’s (bLF) effects on the in vitro growth of neonatal septicaemia E. coli isolates, and to determine the presence of iron acquisition …

Effects Of Compost Incorporated Versus Surface Applied On Soybean Yield And Soil Health, Maheshwari Kuchanapally

Theses and Dissertations

Compost application is increasingly recognized as a sustainable soil management practice that enhances soil health and crop production. However, the method of application, incorporated versus surface applied, may influence its effectiveness in improving soil properties and crop productivity. This study evaluated the effects of compost application method on soybean (Glycine max L. Merr.) yield and soil health at Illinois State University Research Farm in Lexington, Illinois, across two growing seasons, 2024 and 2025. The 2024 experiment used a Completely Randomized Design comparing incorporated versus surface-applied compost (n = 4; 8 plots). The 2025 experiment used a Randomized Complete Block Design …

Reawakening Waⁿdat: Community Research & Reclamation, Darcy Allred

Theses and Dissertations

The Wyandot(te) have undergone language dormancy due to settler colonial impacts of warfare, refugee relocation, forced removals, and U.S. assimilation projects. One of the most pressing priorities among our people today is reawakening our ancestral language, Waⁿdat. The common follow-up question is: how? Through the conduit of Waⁿdat language reclamation, this project grapples with the above question in collaboration with the Wyandot(te) community, and in adherence to the tribal sovereignty of the Wyandotte Nation. The project engages with diasporic perspectives, community-based pedagogy design, and tribally specific research protocols and policies. The living collective knowledgebase with which I engage in this …

Reconciliation, Draper Matthews

Theses and Dissertations

This thesis exhibition, Reconciliation, examines how memory, loss, and lived experience shape personal identity over time. Through sculptural works composed of cast, blown, and hot-sculpted glass combined with mixed media, the exhibition explores the pressures that life events place upon individuals and the ways those pressures persist, transform, and become integrated into the self. The work considers identity not as a fixed state but as a continual process of negotiation between past experiences, present circumstances, and future possibilities.

Central to the project is the material analogy between glass and human experience. Glass, a material formed under extreme heat and pressure …

Middle School Students' Initial Ideas And Their Connections In Proportion Word Problems, Carrie Ann Lawton

Theses and Dissertations

In this dissertation study, I sought to identify the initial ideas that middle school students had when approaching Multiple Batches and Variable Parts proportion word problems, as well as the connections they made among those initial ideas. I conducted semi-structured individual and paired interviews with 13 sixth- and seventh-grade students at the end of their school year. I then used the Knowledge-in-Pieces theoretical perspective to identify knowledge resources that the participants accessed when approaching the tasks, prior to any intervention on my part.

Through my analysis, I identified 18 initial ideas that the middle school students employed when solving the …

The Effects Of A Work-Strengths Affirmation Intervention On Death Anxiety: Meaning And Self-Esteem As Mediators, Begüm Orhan

Theses and Dissertations

Death anxiety is a transdiagnostic construct and a universally experienced existential fear that has been linked to a wide range of psychological difficulties, including anxiety, depression, and impaired well-being. Despite its widespread impact, empirical research on targeted interventions for death anxiety remains limited. The present study aimed to address this gap by developing and evaluating an online, single-session, theory-based (i.e., Terror Management Theory, positive psychology) intervention focused on affirming personal strengths in the context of one's work. The intervention was designed to target work-strengths (i.e., leadership, adaptability)—an intersection of positive and vocational psychology.

College students from a large Midwestern university …

Tooth Ablation And The Jōmon - Yayoi Transition In Japan, Laura R. Erickson

Theses and Dissertations

The Jōmon – Yayoi period transition in Japan is marked by many migrants coming through the Korean Peninsula into Kyushu, sparking changes such as the introduction of wet-rice agriculture to the native hunter-gatherer-fisher Jōmon population and decreases in tooth ablation patterns and percentages. Ritual tooth ablation, or the removal of healthy front teeth, is typically seen as a coming-of-age practice, with the Jōmon having a diverse amount of ablation patterns. In this study, I explored how the rates and variation of tooth ablation changed throughout Japan after the arrival of Yayoi migrants from the continent. After calculating ablation rates per …

The Effect Of Sex On The Signal Transmission Of Duetting Bay Wrens, Rachel C. Schinzler

Theses and Dissertations

During communication, senders send signals for their benefit to elicit a behavioral response from a receiver. Acoustic signals are efficient for long-distance signaling; however, they are influenced by environmental features, such as foliage density, humidity, temperature, and time of day. Individuals can overcome these challenges by using signals with a trajectory of peak frequency, frequencies, volumes, and timing best suited to signal transmission in their environment. Signal transmission has been studied at the species level; however, not much is known about sex differences within the same species. Duetting species provide a useful system for examining sex-specific challenges in transmission, as …

Interaction Of The Gram-Positive Human Pathogen Staphylococcus Aureus With Host Lipids, Sharanya Paul

Theses and Dissertations

Staphylococcus aureus is a prominent pathogen that is known to incorporate straight-chain unsaturated fatty acids (SCUFAs) into its lipids in addition to the normally biosynthesized branched-chain fatty acids (BCFAs) and straight-chain fatty acids (SCFAs). Furthermore, it has recently been shown that the incorporation of oleic acid into S. aureus lipids significantly enhanced the growth of the organism at low temperatures due to the greater fluidity imparted to the membrane. Together with others in the Wilkinson and Dahl laboratory, I have shown that low-temperature growth is enhanced by various SCUFAs, including the human antimicrobial fatty acids sapienic acid, linoleic acid, and …

Children’S And Adult Perspectives On Mental Health In Children’S Youth Literature And Media, Edcel J. Cintron-Gonzalez

Theses and Dissertations

My dissertation extends existing work on mental health in children’s literature to examine the different narratives strategies that text, film, and media for young audiences use to connect childhood, caregiving, and emotional wellbeing. Three areas of scholarship—children’s literature scholarship, health humanities work, and feminist care ethics—inform my project. Overall, I am interested in how a variety of genres for young readers represent mental health not only as an individual experience, but also as something shaped by family, culture, community, and adult-child relationships. It is therefore important to delineate the different concepts and frameworks that help make sense of how mental …

Why Make Books In Art Class Or Art In Reading Class? How Storytelling Impacts Youth Literacy And Cultural Dialogue, Holly Lewis

Theses and Dissertations

Given complex factors affecting reading literacy and students’ need for empowerment through creativity, this thesis project will investigate possibilities for combining artmaking with written narrative. Creative solutions, such as integrated and project-based learning activities, are documented as having some of the best positive impacts on overall learning growth (Laur, 2021; Aydin & Mutlu, 2023). Therefore, my thesis includes a discussion on Arts Integration initiatives and an illustrated book for students ages 10-15, which can be used as an example for their own studies into personal narrative. While the research presented here touches on multiple factors affecting students’ self-esteem and willingness …

Turning 30 In 600 Feet, Tate Lewis-Carroll

Theses and Dissertations

This thesis is a poem; it records fourteen consecutive months of the poet’s life through rigorous, daily typing habits with nonoptimal tools and material: a typewriter and 600 feet of receipt paper. Through the adoption of these conditions, and through the dailiness of the habit, this thesis crips and deploys a poetics of chronic impediment for accessing constraint and its role in making. This thesis includes a critical preface which explores some of the poet’s specific relationships to chronic pain, both physical and emotional; forgetfulness and dissociation; and disruption by remembering a decade-long flare of chronic illness and abuse. With …

Investigating Phosphorus Load Trends And Driving Factors In Illinois Watersheds Using Machine Learning Algorithms, Hannah Lartey

Theses and Dissertations

Phosphorus (P) pollution in Illinois watersheds has become a significant water quality concern. Recent studies have shown increasing concentrations in streams and rivers, leading to eutrophication, which damages aquatic ecosystems and threatens human health. This study examines temporal trends in total phosphorus loads across 79 monitoring stations in Illinois from 1979 to 2020 and identifies the main environmental factors that influence P load variability. Trend analyses were conducted using the nonparametric Mann-Kendall and Sen’s slope methods. GIS-based climate, hydrology, and soil property datasets were assembled for each monitoring station. These datasets were used to build machine learning models using the …

Digital Truth Making, Creative Resistance, And Power Negotiation Through Social Media: A Digital Ethnography Of The 2024 Gen Z Uprising In Bangladesh, Mustafizurrrahman Rahat

Theses and Dissertations

This research investigates how social media shaped political participation during the 2024 July Uprising in Bangladesh, focusing on the production and negotiation of political truth, legitimacy, and resistance through everyday digital practices. Rather than conceptualizing social media solely as a communication tool, the study analyzes digital platforms as contested spaces where activists, state-aligned actors, and other participants constructed, circulated, and challenged competing political narratives throughout the uprising.

Drawing on digital ethnography, this study integrates netnographic observation of Facebook groups, pages, hashtags, memes, and protest-related visual content with content analysis, reflexive participant observation, and semi-structured interviews with Generation Z participants. The …

Gendered Resistance: Women’S Strategies Against Military Dictatorships, Argentina And Chile, Maricarmen Canales-Moreno

Publications and Research

This article compares the Madres de Plaza de Mayo in Argentina and the Agrupación de Familiares de Detenidos Desaparecidos (AFDD) in Chile to examine how women transformed their identities as mothers, wives, and daughters into strategies of political resistance under military dictatorship. It argues that maternal imagery, public mourning, and the transformation of private grief into collective defiance enabled women-led human rights organizations to challenge authoritarian regimes while strategically drawing on gender roles those regimes sought to enforce. The article traces the emergence of both organizations, their occupation of public space, hunger strikes, legal action, and engagement with international human …

Evaluating Supplementation Strategies Using Precision Livestock Technologies And Energy Based Models In Developing Beef Heifers Grazing Dormant Rangeland, Kali-Jo Bentz

Electronic Theses and Dissertations

Replacement beef heifer development in extensive grazing systems is challenged by variation in forage quality, supplement intake, and animal behavior, all of which influence the ability to achieve targeted growth prior to breeding. Precision livestock technologies (PLT) enable continuous monitoring of individual animal performance, while energy-based nutritional models support individualized supplementation. However, their application under extensive grazing conditions remains poorly understood. Therefore, the objectives of this thesis were to (1) evaluate heifer utilization of multiple precision livestock technologies and their relationship with animal performance and (2) evaluate the accuracy of an individualized energy-based supplementation model by comparing predicted supplement allotments …

Untangling Ai Openness, Parth Nobel, Alan Z. Rozenshtein, Chinmayi Sharma

Faculty Scholarship

The debate over AI openness—whether to make components of an artificial intelligence system available for public inspection and modification—forces policymakers to balance innovation, democratized access, safety and national security. By inviting startups and researchers into the fold, it enables independent oversight and inclusive collaboration. But technology giants can also use it to entrench their own power, while adversaries can use it to shortcut years and billions of dollars in building systems, like China’s Deepseek-R1, that rival our own. How we govern AI openness today will shape the future of AI and America’s role in it.   Policymakers and scholars grasp the …

Effect Of Corn Processing Methods On Growth Performance, Carcass Characteristics, And Gastrointestinal Health In Ruminants Fed Finishing Diets, Reanna Rae Byrnes-Schoen

Electronic Theses and Dissertations

The objective of this work was to evaluate different feed processing techniques and their impacts on growth performance, carcass traits, and gastrointestinal health in ruminant animals fed in confinement during the finishing phase. Two studies were conducted. The first study evaluated the effect of kernel processing high moisture ear corn (HMEC) on growth performance and carcass characteristics of finishing beef steers. The second study used feeder lambs to evaluate the effect of steam-flaking corn in a finishing diet on growth performance, carcass characteristics, and gastrointestinal tract (GIT) health. The results from the first study using steers demonstrated that feeding kernel …

Gender-Inclusive Language In Spanish: A Data-Informed Sociolinguistic Exploration Of Naming Variation, Silvia Rivera Alfaro, Jonathan Hanon

Publications and Research

ABSTRACT

This paper presents a data-informed sociolinguistic exploration of the variation in the names given to gender-inclusive language in Spanish. We use publicly available Google Trends (GT) data to describe the frequency of usage of different names over time and explore their geographical distribution. To account for the challenges and limitations of using Google Trends, we compare the data with information from two large linguistic corpora (CORPES XXI and Google Books Ngram Viewer). Using these tools, we generate small datasets to explore the intricacies of the topic addressed in this paper. In our literature review, we identified 17 names for …

High Stakes And Random Rewards: A Critical Look At Loot Boxes And Illegal Gambling, Brian T. Wersan

Touro Law Review

Since their inception in the mid-2000s, loot boxes have been legal and virtually unregulated in the United States. Ever-growing mountains of evidence demonstrate the harms of loot boxes, but their structure has not yet been found to be in violation of any current U.S. gambling law, leading to a complete lack of recovery for victims. Certainly, if people experience harm, a legal avenue providing justice must exist. While other avenues are referenced, this Note ultimately argues that loot boxes can be interpreted by courts to satisfy the elements of, and thus, violate multiple state gambling laws, revealing a path to …