Digital Commons Network^™

Chitinase Variants Establish Environmental Inflammatory Lung Conditioning, Yilin Wang

Arts & Sciences Graduate Student Theses and Dissertations

Environmental particulate exposure contributes to the severity and persistence of numerous acute and chronic lung diseases, including asthma, viral pneumonia, acute respiratory distress syndrome, and pulmonary fibrosis. Chitin, a highly abundant environmental polysaccharide present in fungi, insects, and mites, is continuously encountered at mucosal barrier surfaces and functions as an immunostimulatory particulate substrate within the respiratory tract. Acidic mammalian chitinase (AMCase; CHIA) is an evolutionarily conserved mammalian enzyme that degrades chitin-containing particles and regulates inflammatory responses at barrier tissues. Common human CHIA polymorphisms reduce AMCase enzymatic activity and are associated with asthma susceptibility; however, the physiologic consequences of these variants …

Process From Noise: Erosion Threshold Variability And The Morphology Of Gravel-Bed Rivers, Robert Paul Kostynick

Arts & Sciences Graduate Student Theses and Dissertations

Rivers are remarkably consistent as their geometry, width, depth, and slope change systematically downstream in response to differences in fluid discharge and sediment transport throughout a channel. Rivers move both water and sediment through terrains that depend on these downstream geometric adjustments influencing water quality, ecology, infrastructure, channel morphology, and landscape evolution at increasing timescales respectively. Rivers thus influence all aspects of life and define our spatial landscapes that shape boundaries, whether physical, politically, or socially. Nevertheless, a river is dynamic and does not adhere to human-defined boundaries, making it vital that we understand how these features change over time …

Hematopoietic Stem And Progenitor Cell Reprogramming During Breast Cancer Progression Promotes Myeloid-Biased Hematopoiesis, Emily Maria Eul

Arts & Sciences Graduate Student Theses and Dissertations

Breast cancer progression is associated with systemic immune dysregulation characterized by the expansion of immunosuppressive myeloid populations that promote tumor progression, metastasis, and resistance to therapy. However, the mechanisms that sustain pathological myeloid expansion remain incompletely understood. In particular, it remains unknown whether solid tumors functionally reprogram hematopoietic stem and progenitor cells (HSPCs) to drive enhanced myeloid output and if bone-derived signals can regulate tumor-associated hematopoietic remodeling. In murine models of primary and metastatic breast cancer, tumor progression induced the remodeling of the hematopoietic compartment, characterized by the expansion of HSPCs, enhanced myeloid differentiation, and systemic accumulation of myeloid populations. …

Decreased Frequency Of Splenectomy For High-Grade Splenic Injuries Following The Implementation Of An Interventional Radiology Alert Protocol., Maura Kopchak, John Bach, William B Devoe, Brian Dusseau, Katherine A Graham, John Dillis, Thomas Glusich, Jeff Hubartt

OhioHealth Research Institute Articles

Background A vascular interventional radiology (VIR) protocol was initiated at a mature level 2 trauma center on 3/1/2023 to reduce time to vessel puncture to < 60 minutes as per American College of Surgeons (ACS) guidelines. The average time to vessel puncture in the two years prior to protocol initiation was 102 minutes. Following initiation, time to vessel puncture was reduced to 48.2 minutes (p < 0.001). A statistically significant increase in the number of splenic embolizations was noted in the post-protocol group. The primary outcome of the current study was to evaluate if the initiation of a VIR protocol correlated with a statistically significant decrease in splenectomies for high-grade splenic injuries (American Association for the Surgery of Trauma (AAST) grade 3 or higher) in favor of splenic embolization. The secondary outcomes of the study were to assess whether the initiation of the VIR alert protocol improved our rate of splenic salvage, defined as preserved splenic immune function, and if there was a decreased rate of splenectomies across all injury grades. Methods The trauma registry database was queried for all splenic injuries from 1/1/2021 to 9/1/2024. Admission CT scans were used to grade injuries using the AAST Organ Injury Scale. Demographic and clinical characteristics, including severity of illness (ISS), admission INR, age, blood product required pre- and post-intervention, mortality, sex, length of stay, anticoagulant (AC)/antiplatelet (AP) use, mechanism of injury, and need for REBOA (resuscitative endovascular balloon occlusion of the aorta) placement, were collected for all patients. Patients were further broken down into those requiring splenectomy, embolization, or no intervention. Data were analyzed using chi-square and Mann-Whitney U with Jamovi Version 2.3.26.0 (The Jamovi Project, 2023). Results No statistically significant difference was found for clinical or demographic characteristics between groups. Fewer splenectomies and more splenic embolizations were performed in the post-protocol group for high-grade splenic injuries (grade 3), which was statistically significant (p< 0.001). This was also true when all grade splenic injuries were compared (p< 0.001). Conclusion Following the establishment of an institutional VIR alert protocol for active hemorrhage control in trauma patients, more frequent utilization of angioembolization for high-grade splenic injuries was found with a subsequent decrease in splenectomy rate. Implementation of the VIR alert protocol directly correlated with a shift in practice pattern reflecting attempts at splenic salvage for all injury grades.

Mitigation Of The Seductive Details Effect In Children, Allison S. Dobuler

Electronic Theses and Dissertations 2020 - Present

The present thesis examines if interspersing guiding questions between sections of an expository text can mitigate the seductive details effect, in which the addition of interesting but tangentially related information to the base text may hinder the ability to learn the essential material, for typically developing children. Participants were given two passages to read, one with seductive details and one without. They either had no guiding questions for both passages or guiding questions interspersed between the text of both passages. They were given retention and comprehension assessments for both passages. While the guiding questions did not mitigate the seductive details …

Perceiving A Competitor: Culture And Cognitive Biases Of The Strong Enemy And The Pacing Threat, Allison Abbe

Books, Monographs & Collaborative Studies

The United States and China are prone to systematic cognitive and cultural biases that distort their mutual perceptions. Addressing these biases through cultural education and professional development is essential to overcoming blind spots in understanding the United States’ primary competitor. By applying dynamic constructivist theories from cross-cultural psychology to national security, this monograph builds on existing scholarship to reveal specific cognitive asymmetries between Western and East Asian observers. Differences such as holism, dialecticism, social inference, and perspective taking reflect the cultural lenses through which security actors perceive their competitors’ actions and intentions, but US observers often overlook the cultural factors …

How Can Electronic Timekeeping Systems Provide Cost And Time Savings Compared To Manual Time Entry And Paper-Based Timesheets?, Jill Childs

Certified Public Manager® Applied Research

Paper-based timekeeping methods have historically been the default way for both municipalities and businesses to document hours worked by employees. However, due to analog timekeeping’s lack of verification methods, human error and intentional dishonesty combine to make this method unreliable. These discrepancies are also costly, as human resources staff must be compensated for the time it takes to verify entries and correct mistakes, and if unchecked, the falsified time can potentially result in thousands of dollars of unearned wages lost. This article details various methods and motivations for falsification and argues for the implementation of electronic timekeeping systems, such as …

Multimodal Digital Libraries: A Response To Culturally And Linguistically Sustaining Classrooms, Abigail Lopez

Masters Projects

Poorly represented minority groups fail to connect reader identity backgrounds

with the characters in texts due to curriculum traditionally relying on English dominant

translations. This system challenge deficit fails students by placing limitations on the

exposure of rich vocabulary, cultural awareness and sets up lack of engagement. This

project is grounded in Culturally and Linguistically Sustaining Pedagogy, Sociocultural

Theory, Constructing Reader Identities and Engagement theories that transforms

student diversity into an instructional practice that empowers multilingual learners.

To empower students, this digital culturally relevant library optimizes educator

planning time. This digital library provides immediate access to multicultural books

alongside a …

A Comprehensive In-Silico Pipeline For The Discovery Of Non-Toxic, Stable Antimicrobial Peptides From Databases For Targeting Multi-Drug Resistant K. Pneumoniae, Pranab D. Sharma, Abdullah A. Noman, Al Hafiz

Faculty Articles

The rapid emergence of multidrug-resistant Klebsiella pneumoniae has significantly reduced the effectiveness of conventional antibiotics, highlighting the need for alternative therapeutic strategies. This study employed a comprehensive in silico pipeline to identify antimicrobial peptides (AMPs) targeting the essential DNA replication initiator protein DnaA. A total of 28,361 peptide sequences were collected from publicly available AMP databases and sequentially filtered based on peptide length, net charge, GRAVY score, instability index, antimicrobial activity, toxicity, hemolytic potential, aggregation propensity, sequence similarity and favorable amphipathic properties. Four peptides satisfied all selection criteria and were subjected to structural prediction, membrane-binding analysis, protein–DNA docking, protein–peptide docking, …

Sidama Women's Perceptions Of Female Genital Mutilation/Cutting And Marital Fidelity, Mekonnen Doyamo

Walden Dissertations and Doctoral Studies

Female Genital Mutilation/Cutting (FGM/C) affects women from the Sidama region of Ethiopia differently from women in other parts of Ethiopia, which results in different physical and psychological consequences. The purpose of this qualitative case study was to explore why the Sidama people’s FGM/C custom differs from that of other parts of Ethiopia. A case study methodology was used to answer the following research question: How does the practice of FGM/C among the Sidama people in Ethiopia differ from that in other regions regarding its cultural significance and rituals? Moreover, how do community attitudes and beliefs surrounding FGM/C among the Sidama …

Lessons Learned For The Independent Panel For Evidence For Action Against Amr From Previous International Science Panels: Stakeholder Views From The 2025 Lagos Workshop, Iruka N. Okeke, Anthony Mcdonnell, Ayodele A. Akinyele, Javier Guzman, Kevin Outterson

Faculty Scholarship

In September, 2024, the UN General Assembly assigned the Quadripartite Joint Secretariat on Antimicrobial Resistance (AMR) the task of establishing an Independent Panel for Evidence for Action against AMR (IPEA). To promote stakeholder views and input around the constitution and functioning of this Panel, which could feed into the Quadripartite Joint Secretariat’s consultation process, we independently commissioned seven papers to examine the lessons that could be learned from other high-level scientific panels. We then convened 85 stakeholders, primed with the background papers. The Workshop, held in Lagos, Nigeria in April, 2025, drew representation from around the world, particularly low-income or …

Caring But Still Hurting: Uninsured Patients' Illness And Healthcare Experiences At A U.S. Free Clinic, Danaya Amornnimit, Eda G. Christensen, Adelaida Salmeron, Kian Robison, Sofia Ampudia Arroyo, Jessica Benelli, Brenda Spearman, Akiko Kamimura

Patient Experience Journal

While free clinics provide essential healthcare to socioeconomically disadvantaged populations, patients' lived experiences in these settings remain underexplored. This qualitative study examined how uninsured patients at a U.S.-based free clinic perceive their illness experiences and interactions with healthcare providers. From October to December 2024, semi-structured interviews were conducted with 21 adult patients (ages 18–72; M = 49.14), most of whom were non–U.S.-born and primarily Spanish-speaking. Participants described illness as entangled with emotional distress, social isolation, stigma, and disruptions to identity and family roles—revealing a psychological burden that extends beyond physical symptoms. These findings highlight the need to integrate psychosocial and …

Secondary Infertility: A Personal Story Of Loss And Grief, Ben Hughes

Patient Experience Journal

An increasing number of people worldwide are experiencing fertility and this trend is reflected in the data from the United Kingdom. However, most research focuses on the experiences of women and so the male perspective is largely missing from the literature. This narrative is an account of my personal journey of secondary infertility. Presenting a male perspective of infertility provides a point of view which is rarely explored and is about a topic which feels largely a societal taboo. I chart how infertility has changed me, what it has meant to me through my years of trying to come to …

Descriptive Anatomy Of The Female Reproductive Organs In Thamin Eld’S Deer (Rucervus Eldii Thamin) And Fea’S Muntjac (Muntiacus Feae) With Utilizing Of The Glycerin Impregnation Technique For Specimen Preservation, Paisan Tienthai, Pawana Chuesiri, Itti Boonorrana, Piyaporn Kongmakee, Ampika Thongphakdee

The Thai Journal of Veterinary Medicine

The reproductive anatomy of rare cervid species remains insufficiently documented, limiting comparative studies and preservation efforts. This study describes the anatomical details in the female reproductive organs of Thamin Eld’s deer (Rucervus eldii thamin) and Fea’s muntjac (Muntiacus feae), while the application of a modified glycerin impregnation technique was achieved for specimen preservation. Dissections of female reproductive tracts revealed morphological variations that correlate with the known female reproductive characteristics of domestic and closely related species. In both species, the ovaries were characterized as small, ovoid structures, exhibiting prominent follicles or corpora lutea consistent with the stage …

Pluto's Arrival, Salarah Seymour

Digressions: Literary & Art Journal

No abstract provided.

Fraction-Seq: An Integrated Experimental And Computational Workflow For Determining The Localization And Abundance Of Small Non-Coding Rnas In Subcellular Compartments, Siddhartha Shah, Tess Cherlin, Yi Jing, Stepan Nersisyan, Benjamin E. Leiby, Isidore Rigoutsos

Computational Medicine Center Faculty Papers

Small non-coding RNAs (sncRNAs) have garnered considerable attention in recent years, following accumulating evidence of their critical roles in many cellular processes. Among sncRNAs, microRNAs (miRNAs) and their isoforms (isomiRs), tRNA-derived fragments (tRFs), rRNA-derived fragments (rRFs), and Y RNA-derived fragments (yRFs) account for more than 95% of all sncRNAs found in cells. Despite their critical regulatory roles, most sncRNAs remain uncharacterized because their functionalization is a lengthy and challenging undertaking. Knowing an sncRNA's abundance helps prioritize among the various choices, while knowing where it localizes in the cell greatly limits the number and identity of its potential targets and helps …

Research And Innovation Update, August 5, 2026, Office Of The Vice President For Research And Innovation

Office of Research, Economic Engagement and Outreach

No abstract provided.

Self-Maintenance And The Evidence For Artificial Sentience, Mads J. Hansen, Christoffer Lundbak Olesen

Animal Sentience

Birch aims to remain neutral about whether life is necessary for sentience. We argue that life can be given a role while maintaining neutrality. Markers of sentience have been identified in living systems, where some contribute to the system's self-maintenance. When such a marker is reproduced in an artificial system that is not self-maintaining it is not clear that it is as reliable as in living systems.

A Novel Role For The Infralimbic Cortex In Conditioned Fear Responding, Julia R. Mitchell, Samantha Tuberman, Rylin Lubash, Leticia C. N. Takasumi, Emmett Bergeron, Roberto Calitri, Mikaela A. Laine, Maryclare Pikus, Victoria Vance, Leena Ziane, Rebecca M. Shansky

Neuroscience: Faculty Publications

Freezing during Pavlovian fear conditioning is the most commonly used indicator of learned fear in rodents. Although freezing and its neural underpinnings have been widely studied, the field has largely ignored other potential indicators of learned fear. Darting, an escape-like conditioned fear response, occurs more frequently in females and is reliably predicted by a distinct behavioral phenotype: heightened shock response and decreased freezing compared to rodents that do not engage in darting. The experiments in this study sought to expand the field’s understanding of conditioned fear by investigating the neural correlates of conditioned darting, focusing on the infralimbic cortex (IL) …

All The Pretty Ponies, David Rose

Theses

Adopting a nonconventional, narrative approach, this thesis explores a world of ponies where memories become distorted and rewritten through the author’s self-insert of a 'little pink pony' persona to illustrate the psychological states investigated in the exhibit. This paper serves as an artistic companion piece to the thesis exhibition by David Rose that featured these concepts through visual media. David utilizes painting, screenprinting, and animation as mediums for this body of work. This thesis is written like a story because David’s work is founded on the principle of creating and displaying an experience rather than simply stating the facts. Through …

Who I Am, Andrea Per

Maya America: Journal of Essays, Commentary, and Analysis

I have many beautiful memories from my childhood visiting my grandma in the village of Patzicía, Guatemala. Usually, my cousins and I helped her feed her chickens and collect eggs. She also had turkeys, bunnies, and many other animals, including a parrot that my aunts and uncles bought for her so she wouldn’t feel alone during the day. After helping her, Grandma Rafaela usually invited us to enjoy a traditional Maya dinner: black beans, rice, homemade cheese, and handmade tortillas cooked on her comal over a traditional firewood stove, along with a warm drink she made from toasted corn powder. …

Woven In Silence: Maya Q’Anjob’Al Cosmology, Gaspar Tomas

Maya America: Journal of Essays, Commentary, and Analysis

The Q’anjob’al, Akateko, and Chuj communities of the Guatemalan highlands are among many Maya communities that are flourishing with knowledge that draws on the classical-period Maya civilization and infuses it with contemporary practices. This knowledge guided the Maya people in building a stronger relationship with the natural and spiritual worlds: the very foundation of our social structure and the key to understanding our place in this universe. The survival of our culture, our languages, and our oral traditions all played a critical role in preserving our worldview, but the one that stands resilient above all is the one recorded on …

Parks Coble, Jr., Unl History; Chinese Nationalists & Business, Chinese-Japanese Relations, Mark A. Griep, Parks M. Coble Jr.

UNL ORCA Interview Series

Dr. Parks Coble, Jr. was awarded the ORCA in 2005. He was born in Waterloo, South Carolina in 1946 but he grew up in Columbia. He earned his bachelor’s in history at the University of South Carolina in Columbia. Next, he traveled 740 miles northwest to earn his doctorate at the University of Illinois in Champaign. In 1976, he became an assistant professor of history at the University of Nebraska, where he quickly rose through the ranks. His early work focused on the relationship between Chinese business elites and leaders of the Chinese National Government movement during a very interesting …

Evaluating Gender Equity In The Berenstain Bears Picture Books, Christy Tisnawijaya, Geni Kurniati

Bahasa dan Seni: Jurnal Bahasa, Sastra, Seni, dan Pengajarannya

Picture books serve as a foundational medium in early childhood education, utilizing interrelated visual and verbal elements to foster linguistic, cognitive, and social development. Despite their pedagogical utility, certain literary works inadvertently perpetuate traditional gender roles, constraining children's conceptualizations of identity. This study evaluates gender representation within eleven selected titles of The Berenstain Bears series. Employing a qualitative multimodal content analysis, the study integrates Butler's gender performativity framework (1990), Callow's multimodal narrative approach (2020), and Adam and Harper's evaluative criteria (2021) to examine how domestic, social, and recreational roles are constructed. This study offers novelty by establishing a dual-lens multimodal …

The Faunal Remains From The Roman–Early Byzantine Residential Quarter At Oboda (‘Avedat), Nimrod Marom

'Atiqot

Excavations in the town of Oboda in the Negev Highlands yielded faunal remains from Roman and Early Byzantine (late third–early fifth century CE) contexts. It was found that the site’s economy in both periods relied mainly on caprine flocks dominated by sheep.

The Buildings Of Muslim Al-Majdal Asqalān (Ashqelon) In Their Historical-Geographic And Economic Context, Avraham (Avi) Sasson

'Atiqot

In the course of the Mamluk and Ottoman periods, six villages were established in the al-Majdal Asqalān area in the southern coastal plain of Palestine, the status of this area enhancing in the 1830s when its geographic and economic advantages were appreciated. The small villages were built on the kurkar ridge slopes with minimal planning, traversed by two or three main arteries adjoined by narrow lanes. The houses were mostly built of mud bricks. Only the central village, al-Majdal Asqalān, developed on flat ground, where there was ample land for construction: most of its buildings were built of kurkar stones. …

Chimneys In Twelfth-Century, Crusader-Period Residential Architecture In The Jerusalem Area, Michael Chernin, Zubair Adawi, Yehiel Zelinger

'Atiqot

Excavations conducted over the past several decades in the environs of Jerusalem uncovered several rural sites dating to the Crusader period, most likely settled by Frankish inhabitants. At two of these sites, remains of installations identified as chimneys were integrated into the walls of the buildings—an innovation in the rural architecture of the Land of Israel, probably introduced by Frankish settlers originating from Western Europe. This article presents the different types of chimneys exposed at the sites of Khirbat el-Kurum and Wadi el-Ḥaramiya. It discusses the archaeological evidence for the appearance of such installations at sites across the Frankish Levant, …

Gold Rings For Young Girls: Ritual Depositionof Children’S Jewelry In A Domestic Contextin Hellenistic-Period Jerusalem, Marion Sindel, Efrat Bocher, Rikki Zalut Har-Tuv, Yuval Gadot, Yiftah Shalev

'Atiqot

This article examines four gold ornaments and three bronze earrings dated to the late third–early second centuries BCE, retrieved from Building 110 in the Givʽati Parking Lot (GPL) excavations in Jerusalem. Based on their intact state, intrinsic value and similar contexts, we propose that the artifacts were intentionally deposited in or below the building’s floors on different occasions. Technological and stylistic analyses connect the jewelry to broader Hellenistic polychrome traditions, and the exceptionally small rings suggest that they probably belonged to young children, most likely girls. Based on Greek epigraphic and literary evidence for female rites of passage, specifically premarital …

The Importance Of An ‘Unimportant’ Toy: Children In The Ancient Domestic Sphere, Rona S. Avissar Lewis

'Atiqot

This paper examines an often-overlooked sector of households: children. The paper first presents the importance of children within the framework of the household and society, pointing out significant references from textual sources and imagery, such as orthostats. Then, a set of artifacts identified in the archaeological record is presented, which may be defined as spinning toys, comprising two components: a string and a perforated object. The conclusions discuss the way these toys reflect on the importance of children in society.

There’S No Place Like Home: Identifying Women In Iron Age Houses, Deborah Cassuto

'Atiqot

From rural farmsteads to urban environments, the excavation of domestic contexts in the Southern Levant provides a rich dataset for investigating how households structured quotidian activities, social interactions, and meanings through spatial organization. This article examines how the material culture of Iron Age dwellings can aid in reconstructing patterns of behavior, social organization and ideologies pertaining to women. Comparing the contextual distribution of archaeological finds with ethnographic, ethnoarchaeological and textual data, can shed light on the use of space in Iron Age households and how this reflects on gender-associated activities and economic behaviors of the individuals who lived there. This …