Digital Commons Network^™

Colorectal Cancers With Distinct Metastatic Potential Trigger Divergent Early T Cell Responses, Marwa Ahmed Saad

Student Theses and Dissertations

The intestinal mucosa harbors the largest immune compartment in the mammalianbody, where resident and recruited immune cells must maintain tolerance to commensal and dietary antigens while preserving their ability to mount effective responses against pathogens and malignant transformation. Uncontrolled epithelial proliferation leads to colorectal cancer (CRC), the second leading cause of cancer-related deaths worldwide. More than 85% of human CRC cases arise from accumulating sporadic or hereditary mutations in the tumor suppressor genes Apc, Tp53, Smad4, and the oncogene Kras. Although immune checkpoint blockade has transformed the treatment of certain solid tumors, most CRCs, particularly those with a proficient mismatch …

Investigating Primary Motor Cortex Involvement In Mouse Vocal Communication, Elena N. Duryea Waidmann

Student Theses and Dissertations

Vocal communication is used to transmit a range of information to other individuals. While many vocalizations are innate, some species can learn to change their vocal output. This is termed vocal-learning, and it is a rare trait and a necessary building block for human spoken language and songbird song. Comparative work in humans and songbirds suggests that convergent genetic and neural specializations may drive these learned vocal behaviors. Two key features of these advanced vocal learners are: i) specialized primary motor regions in the forebrain with activity tied to vocalization; and ii) dense monosynaptic projections from the primary motor cortex …

Noncanonical Roles Of Hepatitis B Virus Precore Rna In Reverse, Mengyin Zhang

Student Theses and Dissertations

Hepatitis B virus (HBV) is a partially double-stranded DNA virus that replicates through reverse transcription. Transcription from the HBV core promoter generates two genome-length RNAs: pregenomic RNA (pgRNA) and precore RNA (pcRNA). pcRNA contains the entire pgRNA sequence plus an additional 32 nucleotides at its 5’ end that include the precore start codon, enabling translation of the precore protein, the precursor of the secreted HBV e antigen (HBeAg). Whereas pgRNA is translated to produce core and polymerase and serves as the template for reverse transcription by cis-acting HBV polymerase, pcRNA has long been considered unable to support HBV DNA synthesis. …

Amalie Joachim: Reminiscences Of Childhood, Robert W. Eshbach

Faculty Publications

This bilingual edition presents Reminiscences of Childhood, the autobiographical narrative of the Austrian operatic singer Amalie Joachim (née Schneeweiss), in Nina Joachim’s English translation together with the original German text. Written for her daughters, the memoir recounts Joachim’s family background in Carinthia and Styria; her early musical training and exposure to domestic chamber music; the political and personal upheavals of the revolutions of 1848; the death of her father and the family’s subsequent poverty; and her first theatrical engagements in Troppau and Hermannstadt. The narrative offers a vivid first-person account of musical life, female artistic formation, family survival, provincial theatre, …

Accountability For Lawyers And Lawyer-Bashers: Reflections On Wendel's Canceling Lawyers, David Luban

Georgetown Law Faculty Publications and Other Works

This article is part of a symposium on W. Bradley Wendel’s Canceling Lawyers: Case Studies of Accountability, Toleration, and Regret. I agree with Wendel’s two fundamental claims: first, and contrary to the reigning conception, lawyers can be held accountable for choosing to represent a particular client (assuming they have a choice), and therefore that they cannot use their professional role as a “magic shield or force field” (Wendel’s term) to deflect all criticism. Second, however, there is also an ethics of blaming, and critics who blame lawyers irresponsibly can themselves be blamed. One of Wendel’s examples is lawyers who …

Fixed Dune Grassland Mapping, Ronica Reyes, Madison Mayenschein, Jared Cruz

Environmental Science & Management Senior Capstones

Our  study applies Geographic Information Systems (GIS) and field-based data collection to map and assess a degraded fixed dune grassland parcel in Humboldt County, CA. Our project supports restoration planning led by Friends of the Dunes by identifying site features, habitat composition, and disturbance patterns at the site. Using GPS surveys, aerial imagery, and ArcGIS Pro, we mapped infrastructure, cement footprints, debris piles, vegetation types, and habitat boundaries. We mapped infrastructure such as concrete foundations and debris, which contribute to ongoing ecological degradation and the presence of invasive species. In addition, our spatial analysis highlights variability in disturbance. From this …

Removal And Monitoring Of Ammophila Arenaria In A Previously Restored Foredune Site In Humboldt Coastal Nature Center, Lucas Benjamin Griffin, Haylee Lynn Kimball, Maya Contreras, Ava Christenson

Environmental Science & Management Senior Capstones

Coastal dunes are important ecosystems that provide vital habitat for rare and endangered species as well as vital ecosystem services. However, since the late nineteenth century, coastal dune ecosystems have been invaded and altered by Ammophila arenaria, which is a beach grass species native to Europe. The dunes within the Humboldt Coastal Nature Center are one such example of this. This property is currently managed by the non-profit organization Friends of the Dunes, which has been working to restore the dunes' ecology and topography. Our project focuses on the monitoring and maintenance of a 2021 restoration project within a 17,794 …

Vegetation Management Plan And Wildlife Enhancement Project For The Woodley Island Wildlife Area, Sophie Belle Shapero, Brandon Carl Bauch, Moises Ortiz, Angelina Espinoza

Environmental Science & Management Senior Capstones

The Woodley Island Vegetation Management Plan and Wildlife Enhancement Project was created by Cal Poly Humboldt students in partnership with the Humboldt Bay Harbor Recreation and Conservation District as a capstone senior project. This project provides a basic management plan for invasive species and offers suggestions for how to enhance the wildlife areas on the island. The goals of the project are to provide maps of the habitat types within the wildlife reserves, map areas of concern to be targeted for invasive species removal, and provide guidelines for how to increase habitat diversity, wildlife forage, and decrease invasive species presence. …

Woody Ryno Farms Native Prairie Plant Restoration & Invasive Management Conservation Management Report, Jezebel Kenny, Rowan Haeger, Ian Mendonca, Annika Weihl

Environmental Science & Management Senior Capstones

Coastal prairies are biodiverse and sensitive landscapes that support a variety of grassland species in mediterranean climates. Hedgerows may act as a natural barrier for coastal prairies or agricultural regions, aiding in natural protection and support for biodiversity. Humboldt County, California, hosts a number of agricultural regions, including Woody Ryno Farms, a small-scale agricultural operation, on the edge of Dows Prairie near the coast of Mckinleyville. This project aims to continue restoration activity being conducted on the site, helping to increase native biodiversity and agricultural productivity. Project objectives include conducting a plant assessment, applying treatments to individual plants where necessary, …

A Light Unto My Path? Discerning Prophetic Words For The Latino/A Church Today, M. Daniel Carroll R. Ph.D

Apuntes: Reflexiones teológicas desde el margen hispano

No abstract provided.

The Basis Of The Labor Exemption Reconsidered, Sanjukta Paul

Articles

Broadly speaking, this symposium queries the question of expanding some actors’ coordination rights under antitrust law as a way of effectuating legal goals relating to “power relations.” I commend the organizers of the symposium for opening this conversation, for asking about the use of “collective bargaining” beyond the traditional labor domain, and for taking on the question in a creative way. These broader questions are essential, and yet my own article will (paradoxically, perhaps) try to contribute to this effort by going back to the core domain of the labor exemption itself—where, it turns

Cold Comfort: Japan’S “Comfort Women” Litigation Under Transnational Law, Timothy Webster

Faculty Scholarship

Transnational human rights litigation has emerged as a powerful tool to remediate state and corporate abuses. Courts, however, rarely evince the same enthusiasm for these lawsuits as practitioners, scholars, and activists. For the past thirty-five years, “comfort women,” or survivors of wartime sexual exploitation, have used transnational litigation to seek redress from the Japanese government. Yet they have lost nearly all their cases. This Article uses ten “comfort women” lawsuits from Japan to test the limits of transnational human rights litigation. While judges rarely found for the comfort women, their verdicts nonetheless advanced the redress issue by showing the illegality …

Maesa Ramentacea Leaf Extract Protects Against Gentamicin-Induced Nephrotoxicity In Wistar Rats By Modulating Renal Oxidative Stress, Inflammation And Apoptosis, Fahmida Akter, Md Shafiqul Islam Sovon, Baizid Hossain, Md Ariful Islam, Subrato Das, Anik Biswas, Md Sohorab Uddin, Md Mahmudul Hasan

Faculty Publications

Background: Gentamicin-induced nephrotoxicity continues to be a significant clinical concern, while effective and safe protective options remain limited. The nephroprotective potential of Maesa ramentacea has not yet been explored. To address this gap, the present study investigated the ethanolic leaf extract of M. ramentacea (MR-LEE) for its effects on gentamicin-induced kidney injury in Wistar rats. Methods: GC-MS profiling was employed to identify bioactive metabolites. Rats were categorised into five groups: control, gentamicin (100 mg/kg), gentamicin combined with silymarin (100 mg/kg), gentamicin combined with MR-LEE (200 mg/kg) and gentamicin combined with MR-LEE (400 mg/kg). Renal biomarkers, oxidative stress indicators, inflammatory and …

A Comprehensive Survey On Facial Expression Generation: From Gans To Llm-Guided Multimodal Models, Murad Hasan, Rabab Abdelfattah, Kareem Abdelfatah, Mostafa Fouda, Ahmed Sherif

Faculty Publications

Facial expression generation (FEG) has emerged as a vital area in human–computer interaction, virtual avatars, and affective computing, aiming to synthesize natural and expressive facial behaviors across diverse interaction contexts. This survey presents a comprehensive analysis of recent advances in FEG, organized into six key paradigms: speech-driven expression generation, facial reaction generation, face video generation, facial animation, avatar-based generation, and text-driven expression generation. We review a wide range of model architectures, including VQ-VAEs, Generative Adversarial Networks (GANs), 3D Morphable Models (3DMMs), Transformers, and diffusion-based approaches, and compare their performance using commonly adopted evaluation metrics such as Fréchet Distance (FD), Peak …

Evaluation Of Brook Trout (Salvelinus Fontinalis) Thermal Tolerance And Projected Climate Change Effects On Headwater Brook Trout Population Persistence, Cory Bauerlien

Graduate Theses, Dissertations, and Problem Reports (ETD)

Climate change has been identified as one of the greatest threats to global biota in recorded human history. Consequences are expected to be more pronounced in ectotherms because most of their physiology is controlled by external temperature conditions. Predicting how ectotherms may respond to increasing global temperatures necessitates information about thermal limits of thermal sensitive species and how increasing temperatures may affect individual and population-level fitness. Therefore, the objectives of this research were aimed at gaining a better understanding of the mechanisms that underpin thermal tolerance limits of fish and how those mechanisms may affect fitness and population persistence under …

State Complicity And The Threshold Of Knowledge: From Fragmentary Evidence To Evidentiary Saturation, Christina Bradic

Case Western Reserve Journal of International Law

The International Court of Justice’s (ICJ) 2007 judgment in Bosnia v. Serbia turned on evidentiary gaps. Although the ICJ recognized that genocide had been committed at Srebrenica, it declined to hold Serbia complicit, reasoning that the record did not prove awareness of genocidal purpose. Intelligence was piecemeal, contemporaneous witnesses were scarce, and the ICJ refused to infer knowledge absent direct proof.

Two decades later, the evidentiary environment looks radically different. In October 2024, ninety-nine American healthcare professionals who had volunteered in Gaza sent an open letter to the White House reporting that children with gunshot wounds to the head or …

Equal-Access Extraction: Necessary Revisions To The Extent Of The 1920 Svalbard Treaty Due To Norway's Deep-Sea Mining Decision, Louden J. Keihl

Case Western Reserve Journal of International Law

Svalbard’s 100-year-old governing treaty, the Svalbard Treaty, has been the cause of several disputes regarding its applicability to maritime zones not developed at the time of its negotiation. This Note argues that, considering Svalbard’s importance, the different treaty parties should renegotiate and revise the Svalbard Treaty to clarify ambiguities regarding its geographic scope. The reasons why the dispute has not been solved to date and the differing views on the Treaty’s geographic scope are also discussed. Potential clarifying language is proposed and analyzed. (from the author)

Protecting Wild Animal Abundance, Natalie Jacewicz

Utah Law Review

Americans today encounter billions fewer wild animals than their grandparents did. These ongoing losses affect an enormous array of interests, including billions of dollars in costs to agriculture, tourism, and land management, as well as lost wildlife encounters. Dramatic declines in wild animal abundance reveal a blind spot in American law: In general, environmental law does not aim to protect the “supply” of wild animals we think of as common. Because scientists have only recently begun to appreciate the scale of common animal loss, the phenomenon has received comparatively little attention from legal scholars. This Article sets forth the problem …

Assessing The Ecological Vulnerability Of Natural Flood Defences And Risks To Agricultural Land Following Seawater Flooding, Cally Barratt

School of Biological and Marine Sciences Theses

Anthropogenic climate change is intensifying extreme weather events, affecting the natural environment by altering ecosystems, and leading to habitat loss. Pressingly, the frequency and severity of storm surge flooding in low-lying coastal regions is projected to increase under future climate scenarios. There is a growing need to understand how these events will impact coastal ecosystems, and the measures that can be taken to mitigate against these effects and protect natural resources. Furthermore, with increased pressures placed on agriculture to meet food demand, protecting arable land resources in coastal regions from the rising threat of flooding is imperative. This thesis explores …

Influence Of Ecological Transitions On The Evolution Of Circadian And Light Detection Genes In Squamates, Isobel Sleep

School of Biological and Marine Sciences Theses

Circadian rhythms are self-sustaining, endogenous processes that align behaviour and physiology with daily environmental cycles. Rhythms are regulated by conserved genes forming transcriptional feedback loops and are entrained by environmental cues (e.g., light). Circadian systems are well studied in model organisms, their molecular evolution in squamates (lizards and snakes) remains less understood. Squamates represent the most species-rich reptile group with extensive ecological and sensory diversity, exhibiting multiple independent transitions across ecological niches, including repeated shifts into low-light environments (e.g., nocturnality, fossoriality), making them ideal for examining circadian and light-associated gene evolution. This study investigates how ecological transitions have influenced the …

Coping With Climate Change: The Role Of Plasticity Within And Across Generations, Caitlin Mcandry

School of Biological and Marine Sciences Theses

Climate change is leading to increased mean temperatures and more frequent and severe temperature anomalies, threatening organisms globally. Phenotypic plasticity, the ability of a given genotype to express different phenotypes in different environments, may offer a mechanism that allows organisms to temporarily persist in a rapidly changing environment, ultimately buying time for genetically based adaptations to evolve. Plasticity has been demonstrated both within and across generations, in response to different environmental stressors. However, our understanding of the interactive effects of plastic responses across levels of biological organisation, and over temporal scales from hours to generations, is still limited. Additionally, we …

Structures Of Fantasy In Terry Gilliam's 'Time Bandits', Sean Fash

West Chester University Graduate Theses, Dissertations, and Final Projects

Terry Gilliam’s use of fantasy genre conventions in his filmography is obvious in presence, but elusive in understanding.  Time Bandits, as an early entry into this filmography, simultaneously seems to mock and embody these genre conventions.  This paper seeks to find a way to understand Time Bandits on a structural level through existing frameworks in fantasy criticism and to see what deeper meanings the film holds behind its silly, fantastical presentation.  These structural templates of analysis are John Clute’s “full fantasy model” from his Encyclopedia of Fantasy and Farah Mendlesohn’s “portal quest fantasy” from her Rhetorics of Fantasy.  By deconstructing …

Unexpected Longevity In Myasthenia Gravis, Bhupendra O. Khatri, Scott Schutten, Sergey Tarima

Biostatistics Faculty Publications

Background: This study compares age at death in patients with myasthenia gravis (MG) and multiple sclerosis (MS) with the general U.S. population and examines age at death patterns during a period preceding modern high-efficacy therapies. Objective: To compare age at death among individuals with MG and MS with the general population and assess differences in age at death between MG and MS. Design: Retrospective population-based study using death certificate data from four U.S. states (Florida, Wisconsin, Texas, and New York) for 2000, 2005, 2010, and 2015. Methods: Individuals with MG or MS listed on death certificates were identified. Age at …

Catwalk Xt Enables Sensitive Detection Of Locomotor Deficits After C2 Hemisection And Integrates Readily Into Ongoing Experimental Workflows In Adult Female Rats, Aaron L. Silverstein, Christopher M. Calulot, Christopher J. Mclouth, John C. Gensel, Warren J. Alilain

Biostatistics Faculty Publications

Over half of all spinal cord injuries (SCIs) in the United States occur at the cervical level and often cause both life-threatening breathing dysfunction and profound locomotor deficits. Although the C2 hemisection (C2Hx) model is vital for study of breathing dysfunction after experimental SCI, post-C2Hx locomotor deficits have only been assessed by metrics such as the Martínez Scale and ladder tests, which require time-intensive scoring by human observers. However, the CatWalk XT Gait Analysis system (Noldus Information Technology) delivers automated, quantitative assessment of interlimb coordination, gait cycle, and paw function, providing robust locomotor data in a time-efficient and practical manner. …

Digital Lover: Insecure Attachment Styles And Romantic Parasocial Relationship Among Chinese Female Otome Game Playersdigital Lover: Insecure Attachement Styles And Romantic Parasocial Relationship Among Chinese Female Otome Game Players, Weifan (Kyrie) Zhang M.S.

Selected Full Text Dissertations, 2011-

The existing literature has explored the relationship between insecure attachment styles and parasocial relationships, particularly focusing on traditional media such as television. However, it has largely overlooked the novel form of media represented by contemporary Chinese otome games, which offer an idealized digital environment potentially more appealing to players with insecure attachment styles. Moreover, previous studies have not sufficiently differentiated between general parasocial interactions and the specific nuances of parasocial romantic relationships unique to romantic video games (RVGs). This study seeks to bridge these gaps by examining the psychological underpinnings of Chinese female players' engagement with female-oriented romantic video games. …

Design, Syntheses And Biological Applications Of Fluorescent Probes For Nad(P)H, Hsa And Cellular Microenvironment Sensing, Adenike M. Olowolagba

Dissertations, Master's Theses and Master's Reports

Fluorescent probes have emerged as powerful tools for investigating complex biological processes due to their high sensitivity, selectivity, and capability for real-time, non-invasive imaging. In particular, the detection of key biomolecules such as NAD(P)H, viscosity-related parameters, human serum albumin (HSA), and pH is essential for understanding cellular metabolism, redox homeostasis, and disease progression. In Chapter 2, three coumarin-based fluorescent probes (A–C) were designed, synthesized, and characterized for monitoring NAD(P)H levels in living cells. Probes A and B feature coumarin–cyanine hybrid structures linked via vinyl and thiophene bridges to 3-quinolinium acceptors, respectively, while probe C incorporates a dicyano moiety to replace …

Spatiotemporal Patterns Of Migratory Songbird Habitat Use: An Analysis Of Environmental Drivers At The Net Level, Garrett Kucharski

Dissertations, Master's Theses and Master's Reports

Many eastern North American migratory songbirds are declining at alarming rates, and growing evidence suggests that events occurring away from the breeding grounds, particularly during migration, can be major drivers of these trends. Stopover sites are a key component of migration because they are where birds rest, refuel, and recover before continuing long-distance movements, yet the ecological factors that shape how broadly different species use stopover habitat remain unresolved. From both an applied perspective, identifying habitat attributes associated with use by the greatest diversity of migrants will help land managers prioritize and restore stopover sites, actions that may contribute to …

Mechanical Fractionation Of Wheat Middlings For Application In Pyrolysis And Animal Feed, Okwudili I. Obiakor

Dissertations, Master's Theses and Master's Reports

Wheat middlings are grain byproducts that are underused for bioenergy production despite having a high lignocellulose content. Its use as a feedstock for catalytic pyrolysis depends on effective and sustainable fractionation to enhance efficiency and product yield. This study tested mechanical pre-fractionation (sieving and air classification) to reduce ash content of certain fractions to < 1% for catalytic pyrolysis and enrich nutrient levels of other fractions for feed applications. Wheat middlings were separated into 11 fractions using screen sizes from 106 µm to 1651 µm, and the composition of each fraction was characterized (ash, protein, structural carbohydrates, lignin, starch, and simple sugars). For cyclone separation, a full factorial design was used to study the effect of air velocity (15,18, 20 m/s) and feed rate (33, 35, 38 kg/h) on the amount of material collected in the underflow and overflow, and the composition of these fractions was characterized. Sieving showed a pronounced segregation of ash content, from 4.5% to 6.5% in wheat middlings fractions, with 5.7% being the lowest for coarse fractions which has higher lignocellulose content, and 4.5% in the fine fraction (150-212 µm). The same defined enrichment was observed in all nutrients except for protein. Starch enrichment zone were defined in the fine fractions (212 µm and below), for structural carbohydrates and lignin in the coarse fractions (600 µm and above), and for ash in coarse fractions (1180-1651 µm). In contrast, protein content was not significantly different between various fractions (p value=0.787). The fiber rich fraction (> 600 µm), suitable for pyrolysis, which have a composite ash value of 6.0% can be sorted and mixed with intermediate fractions to reduce ash to 5.3% and the remaining fractions rich in digestible nutrients used for animal feed formulation. Compared to sieving, cyclone separations did not …

Fluctuation Of Organochlorine Concentrations In Bull Sharks At Different Life Stages, Mackenzie R. Phillips

Dissertations, Master's Theses and Master's Reports

For Carcharhinid species such as the bull shark (Carcharhinus leucas), the maternal offloading of nutrients is essential for pup development and growth, however, significant amounts of OCs are also transferred. As a top predator in aquatic food webs, bull sharks can potentially bioaccumulate high concentrations of pollutants such as dichloro-diphenyl-trichloroethane (DDT) that biomagnify through aquatic food webs. These pollutants are also hydrophobic and fat soluble and therefore pose toxicity risks to developing young bull sharks. In this study, liver tissues collected from juvenile bull sharks inhabiting Florida’s coastal waters were analyzed for a suite of organochlorine pesticides (OCs) …

Reading Between The Lines: Protected, But Not From Interpretation, Hooriya Habib

Dissertations, Master's Theses and Master's Reports

In the realm of television, audiences are interactive viewers who decode meaning based on their lived experiences. Given that each culture has its own set of cultural codes it uses as a lens to navigate life, meanings do not remain constant. This cultural media study breaks down three advertisements to study the effectiveness of these advertisements in relation to religious and cultural codes. Using Stuart Hall’s (1980) encoding/decoding model, an oppositional reading was employed to understand the disconnect that may be caused between an audience of rural Pakistani women and the producers. Objects of focus were nonverbal codes such as …