Digital Commons Network^™

Nanosecond Electric Pulses As A Novel In Situ Vaccination Strategy For Cancer Treatment: Mechanisms, Challenges And Prospects, Siqi Guo

Bioelectrics Publications

Nanosecond electric pulses (nsEPs) are an emerging pulsed-power technology with unique bioelectric characteristics distinct from conventional long-pulse electroporation. As a tunable physical modality, nsEPs can modulate intracellular structures, membrane dynamics, and signaling pathways. Increasing evidence supports nsEPs as a promising non-thermal tumor ablation approach due to their high spatial precision, preservation of critical tissue structures, and minimal adverse effects. One of the most significant discoveries associated with nsEP tumor ablation is the induction of potent systemic antitumor immunity, particularly in situ vaccination (ISV) effects and, in some cases, abscopal effects against distant untreated tumors. Substantial evidence demonstrates that nsEPs can …

Hsp90 Inhibitor, At13387 Mitigates Chronic Lung Injury In Pre-Pubertal Mice: A Therapeutic Axis In Bronchopulmonary Dysplasia, Pavel A. Solopov, Christiana Dimitropoulou, John D. Catravas, Ruben M. L. Colunga Biancatelli

Bioelectrics Publications

Exposure to hydrochloric acid (HCl) can provoke severe chronic pulmonary injury. Children are particularly vulnerable due to their smaller airways, higher respiratory rate, and stronger inflammatory response; yet no countermeasures exist for HCl-induced chronic lung injury in the pediatric population. We have previously demonstrated the involvement of HSP90 during HCl-induced lung injury in pre-pubertal (p24) mice, who develop stronger persistent inflammation with higher NLRP3 inflammasome activation, but less pulmonary fibrosis compared to adults. Here, we tested the hypothesis that post-treatment with the second-generation HSP90 inhibitor AT13387 (Onalespib), administered subcutaneously beginning 24 h after HCl instillation, would prevent HCl-induced chronic lung …

Assuming Accent: Recognizing The Intersection Of Race And National Origin In Title Vii Discrimination, Eun Hee Han

University of Colorado Law Review

No abstract provided.

Muinji’J Asks Why (2022) By Shanika Maceachern And Breighlynn Maceachern, Maughn Rollins Gregory

Picture Books

In the nineteenth and twentieth centuries American and Canadian government agencies and Christian churches established Indian residential schools where hundreds of thousands of children were “reeducated” in English and Christianity. They were not allowed to use their native languages or given names, to practice their religions, or to communicate with their siblings or parents. They were made to work in crop fields, kitchens, laundries, and industrial workshops. Many were physically and sexually abused. Many never saw their families again. The nine picture books reviewed here are accounts of survivors of residential schools from eight different Indigenous nations. In addition to …

Memoryart: Enhancing Llms Via Multi-Memory Models With Adaptive Resonance Theory For Healthcare Agents, Renke Dai, Hebin Hu, Jiahui Zhang, Yilin Kang, Ah-Hwee Tan

Research Collection School Of Computing and Information Systems

Though promising in healthcare consultation applications, large language models (LLMs) face critical limitations in retaining and utilizing long-term memory across multiturn interactions. In particular, existing memory enhancing paradigms are constrained by limited context windows and embedding-based retrieval, often failing to maintain task relevance and still suffering from memory prototype collapse in multi-turn healthcare consultation. To address these challenges, we propose a cognitively-inspired memory framework named MemoryART, which is grounded in Adaptive Resonance Theory (ART)—a cognitive and learning theory of how humans and animals adapt to dynamic environments. MemoryART employs three memory modules—working memory, episodic memory, and semantic memory to support …

Intermittent High-Fat, High-Sugar Access During Adolescence Drives Binge-Restriction Feeding And Reduced Weight Gain In A Food Unpredictability Model, Calvin G. Miller

CMC Senior Theses

Food insecurity affects nearly 48 million Americans and 318 million people worldwide, with very low food security disrupting normal eating habits through “feast-or-famine” episodes characterized by cycles of food overconsumption followed by restriction. This dietary pattern alters dopamine signaling within the mesocorticolimbic system — brain circuitry intimately linked to reward processing. This system includes the ventral tegmental area (VTA) and prefrontal cortex (PFC). Overstimulation can be promoted through sporadic high-fat, high-sugar diet (HFHSD) exposure, promoting dopamine neuron architecture alterations and binge-eating behavior. Adolescence represents a vulnerable window, as mesocorticolimbic dopamine projections undergo maturation during this period. Though evidence links food …

Adolescent Binge-Like Feeding And Neuroinflammation: Effects Of Intermittent Palatable Diet Access On Microglial Activation In The Brain In Adolescents, Jaimie T. Yu

CMC Senior Theses

Binge eating disorder (BED), one of the most common eating disorders in the United States (Definition & Facts for Binge Eating Disorder - NIDDK, n.d.), is characterized by recurrent episodes of consuming large quantities of food in a short period of time accompanied by a sense of loss of control. The intermittent access (INT) model reliably produces binge-like eating in adult rodents, with animals showing episodic hyperphagia upon time-limited access to a high-fat, high-sugar (HFHS) diet. In adult female rats, INT access produces elevated meal size and reduced satiety ratio relative to controls (Maske et al., 2020), and promotes microglial …

Morals Without Movement: Veganism, Contentious Politics, And The Lifestyle Politics Constraint, Luke M. Carfaro

CMC Senior Theses

This thesis examines whether veganism constitutes a social movement through Social Movement Theory frameworks, emphasizing Sidney Tarrow's Power in Movement. Through analysis of veganism's empirical properties (collective challenge, common purpose, collective identity, and sustained interaction) and key procedural mechanisms (framing, mobilizing structures, and repertoires of contention), this thesis determines that veganism fails to meet the empirical criteria of a social movement and is more accurately classified as a lifestyle movement—a movement in which political participation is expressed through private consumption rather than sustained collective contention. Using the Make America Healthy Again movement as a counterexample, this thesis comparatively illustrates …

Constitutional Rights, Human Dignity, And The American Dream: A Historical Analysis Of U.S. Immigration Policy After 9/11, Shelby Mcilroy

CMC Senior Theses

This thesis examines how United States immigration policy transformed after September 11, 2001 and asks whether modern immigration enforcement remains consistent with constitutional principles, human rights protections, and the broader ideals associated with the American Dream. The project investigates how immigration shifted from a primarily civil administrative system into one increasingly defined by surveillance, detention, and punishment. The central question guiding this research is whether the securitization of immigration has reshaped not only enforcement practices, but also the meaning of constitutional protections and human dignity for both citizens and noncitizens.

To answer this question, this thesis conducts a historical policy …

Neuroimaging Correlates Of Differences In Learning From Repeated Probabilistic Outcomes, Allison E. Rudolph

CMC Senior Theses

Learning from experience requires integrating feedback over time, yet individuals vary widely in how effectively they extract structure from probabilistic environments. This study examined how such variability relates to neural responses in the ventral striatum (vStr), caudate nucleus, hippocampus, and medial prefrontal cortex (mPFC). Seventy-four participants across childhood, adolescence, and adulthood completed a modified Iowa Gambling Task during fMRI scanning, choosing whether to play or pass on four machines differing in expected value and variance. Behavioral learning slopes, calculated across six runs for each machine, were used to classify participants as learners or non-learners. Learners showed clearer improvement over time …

Has Liberalism Failed? Analyzing The New Right’S Critique Of Liberalism Through Its Historical Arc, Frederick (Gus) G. Mahler

CMC Senior Theses

This paper examines the historical evolution of American political culture to evaluate whether liberalism is responsible for the social and political crises confronting the United States today. Although liberalism has been foundational to American governance and national identity since the country’s inception, a growing movement known broadly as the New Right now claims that it has failed and must be replaced. I seek to assess the legitimacy of this claim.

Using qualitative historical analysis, I trace how the form liberalism takes and the role it occupies in America’s political order has changed throughout the nation’s development. Liberalism was not always …

Politics Of A Silent Pandemic: Antimicrobial Resistance And State Capacity In India And Nigeria, Mia Kelly

CMC Senior Theses

Antimicrobial Resistance (AMR) has emerged as one of the most pressing yet widely underestimated health threats of the 21st century; this thesis explores the potentially devastating global impact of this “silent pandemic”, exposing how deeply health outcomes depend on political choices, regulatory capacity, and economic constraints. Although the danger of spreading drug-resistant pathogens is now widely acknowledged in both the scientific and political communities, states differ in their abilities to contain the issue, with low- and middle-income countries facing the greatest obstacles to national action plan implementation. This thesis investigates these disparities through a comparison of India and Nigeria, two …

Criminalizing Motherhood: Abortion, Obstetric Emergencies, And State Power In Post-1998 El Salvador, Valery M. Reyes

CMC Senior Theses

This thesis examines how a series of regressive legal reforms in El Salvador–the 1997 Penal Code’s expansion of abortion-related punishments and the 1999 constitutional amendment defining life as beginning at conception–eliminated all exceptions to abortion and transformed a woman’s reproductive body into a site of surveillance. Rather than expanding rights, these reforms rolled back on existing protections by not recognizing obstetric emergencies, miscarriages, or cases of rape as legitimate grounds for abortion. Prosecutors and judges could treat such medical emergencies as convictions for “fetal homicide,” carrying sentences of 30-50 years in prison.

Court documents, reports from non-government organizations …

An Intuitionistic Fuzzy Hypergraph Model Enhanced ‎By Forest-Of-Walks Dynamics For Medical Image ‎Segmentation, Brinthaguru Thangaraj, Karthick Palanisamy

Mansoura Engineering Journal

The process of accurately segmenting Urolithiasis and pulmonary nodules from medical images presents significant difficulties because of three main factors which include nonuniform intensity distribution and the presence of weak object borders and the uncertainty caused by anatomical structure overlaps. The study introduces F-Zinhger as a solution to these problems through its application of the Forest of Walks technology. The method uses superpixels as fundamental elements which form a multi-scale hypergraph that establishes hyperedges through three criteria: intensity similarity, spatial proximity, and Z-intuitionistic fuzzy hesitation to capture complex contextual connections. The system incorporates a random walk-based label propagation system. The …

Sex Differences In The Use Of Cognitive Strategies In Brown-Headed Cowbirds (Molothrus Ater), Nicole E. Robinson Ms.

Theses and Dissertations (Comprehensive)

Cognition is widely believed to be adaptive, yet few studies directly show that variation in cognitive performance is related to fitness. Brown-headed cowbirds (Molothrus ater) provide a powerful system for addressing this gap because brood parasitism creates strikingly different reproductive problems for females and males. Females face the spatial demands of nest-prospecting, whereas males face social and competitive demands associated with access to mates. Across five experiments, cowbirds were tested on an outdoor foraging task designed as an analogue of nest prospecting, with manipulations of retention interval, cue conflict, and breeding condition, followed by observations of reproductive behaviour. …

Cross-Domain Antimicrobial Resistance In Poultry Farming: A One Health Assessment Of Antimicrobial Use And Multidrug Resistance In Kiambu County, Kenya, Ann Kangai Munene, Peter Muiruri Mwangi, Lilly Caroline Bebora, Christine Minoo Mbindyo, John Muthini Maingi

All Peer-Reviewed Publications

Background and Aim: Antimicrobial resistance (AMR) has emerged as a major One Health threat driven by inappropriate antimicrobial use (AMU) in humans, animals, and the environment. Poultry production is recognized as a key reservoir of antimicrobial-resistant bacteria, yet few studies in Kenya examine AMU and AMR across interconnected human–animal–environment domains. This study assessed AMU patterns among poultry farmers in Kiambu County and characterized phenotypic resistance in Escherichia coli and Enterococcus spp. isolated from humans, chickens, and chicken environments. Materials and Methods: A cross-sectional study was conducted from May to September 2024, involving 102 poultry farms. Farm demographics and AMU data …

Roles Of Cytokines In Modulating Trypanosoma Brucei Rhodesiense Infection Outcomes In Vervet Monkeys, Clarah Jebet, John Kibuthu Thuita, Daniel Masiga, Benedict Owino Orindi, John Oidho, Mark C. Field, Enock Matovu, Vincent Owino Adung’A

All Peer-Reviewed Publications

Introduction:

Human African trypanosomiasis (HAT), caused by Trypanosoma brucei rhodesiense, is categorized as acute due to rapid disease progression but presents varying clinical outcomes. Although the mechanisms underpinning differential clinical progression are poorly understood, both host and parasite factors are implicated. Therefore, we sought to elucidate roles of primate host factors in mediating varying T. b. rhodesiense infection outcomes.

Methods:

Here, we assessed the roles of selected host cytokines in disease progression using a tsetse-mediated infection in a non-human primate (NHP) vervet monkey model that closely mimics HAT and natural infection. We quantified eight cytokines, including TNF-α, IFN-γ, IL-10, IL-6, …

Impact Of Environmental Microparticles On Insect Olfaction, Steve B.S. Baleba, Danube K.N. Wandji, Yves H. Tchiechoua, Komi Mensah Agboka, Iman B. Hassaballa, Victor O. Omondi, Beatrice T. Nganso, Saliou Niassy, Souleymane Diallo, Merid N. Getahun

All Peer-Reviewed Publications

Terrestrial insects underpin key ecosystem services, including pollination, herbivory regulation, decomposition, nutrient cycling, and disease control. These functions depend on chemical communication that guides insects to food, mates, hosts, shelters, and oviposition sites while helping them avoid threats. Environmental microparticles, such as micro- and nanoplastics, tyre wear particles, soot, mineral dust, and agricultural residues, are now widespread across air, soil, vegetation, and indoor environments, exposing insects through contact, deposition, and ingestion. Growing evidence shows that these particles disrupt insect olfaction by adsorbing volatile compounds, blocking antennal sensilla, and interfering with receptor and neuronal processes. These disruptions impair foraging, mating, oviposition, …

A Systematic Review And Meta-Analysis Of Mosquito Arboviral Infections Detected Through Xenosurveillance In Africa: A Focus On West Nile, Rift Valley Fever, And Chikungunya Virus Infections, Mxolisi Mgongoma, Armanda Bastos, Abel Ramoelo, David P. Tchouassi

All Peer-Reviewed Publications

This systematic review and meta-analysis comprehensively evaluated the mosquito arboviral infections with West Nile virus (WNV), Rift Valley fever virus (RVFV), and chikungunya virus (CHIV), detected through xenosurveillance, reported in mosquito vectors across Africa in the last 25 years (2000–2024). The study analysed xenosurveillance data from 45 studies conducted with over 115,000 mosquito specimens, and incorporated moderator analyses to assess the influence of trap type, seasonality, regional location, settlement type, and screening methods on virus detection rates. The estimated pooled prevalence of WNV was 1.18% (95% CI: 0.60–3.43%), with higher rates observed in Culex quinquefasciatus and Culex pipiens, particularly in …

Pathways, Outputs And Impact Of Nih-Supported Bioinformatics And Genomics Graduate Trainees In Africa, Daudi Jjingo, Andrew Walakira, Suhaila Hashim, Cisse Cheickna, Ronald Galiwango, Caleb Kibet, Florence N. Kivunike, Gerald Mboowa, Fredrick Elishama Kakembo, Babajide Ayodele, Jean Baka Domelevo Entfellner, Santie De Villiers, Karen Wambui, Segun Fatumo, Tinashe Chikowore, John Mukisa, Alfred Ssekagiri, Nicholas Bbosa, Julius Mulindwa, Samuel Kyobe, Mike Nsubuga, Grace Kebirungi, Eric Katagirya, Savannah Mwesigwa, Ibra Lujumba, Rogers Kamulegeya, Samuel Kirimunda, Stephen Kanyerezi, Shahiid Kiyaga, Ivan Sserwadda, Davis Kiberu, Daniel Masiga

All Peer-Reviewed Publications

Global biomedical and health research is increasingly relying on genomic and computational approaches, largely driven by the increasing volumes of nucleic acid sequencing. Concurrently, epidemiological studies and clinical records are generating enormous amounts of data amenable to disease modeling, machine learning, and artificial intelligence techniques. Bioinformatics and data science expertise is therefore essential for improved population health. Accordingly, in 2012, the US National Institutes of Health (NIH) in partnership with the Wellcome Trust, and with support from the African Society for Human Genetics, initiated the H3Africa (Human Heredity and Health in Africa) consortium. One of its key goals was to …

The Impact Of Teachers’ Roles As Boundary Crossers And Boundary Objects In Post- Covid Composition Instruction, Tammie Marie Pierce

Theses and Dissertations

This qualitative case study examined secondary English Language Arts (ELA) teachers’ perceptions of rapid technology integration and its influence on composition instruction and cognitive load in physical, digital, and hybrid spaces. Grounded in theories of boundary crossing and the Cognitive Theory of Multimedia Learning, the study conceptualized teachers as both boundary crossers, navigating instructional spaces, and boundary objects, serving as the support tools for their students’ transitions into digital composition. Data were collected from five ELA teachers in a rural school district through surveys, individual interviews, and questionnaires, and analyzed using a two-phase coding process. Findings indicate that teachers perceived …

Evaluating Rate Of Perceived Exertion And Heart Rate In High School Weight Training Students For Assessing, Enhancing, And Maintaining Health-Related Fitness, Nicholas Searcy

Theses and Dissertations

This mixed-methods study evaluated the relationship between rating of perceived exertion (RPE) and heart rate (HR) among high school weight-training students during circuit training sessions. The purpose of this study was to determine whether RPE could serve as a practical method for gauging moderate to vigorous physical activity (MVPA) among high school weight-training students while allowing students to assess and enhance their health-related components of fitness. Participants were high school students enrolled in weight-training classes who completed upper- and lower-body circuit training sessions over a 4-week period, or a total of 16 school days. RPE was self-reported using Borg’s CR10 …

Determining Knowledge Gaps In Natural Disaster Preparedness: An Exploratory Analysis Of Socioeconomic Variables And Response Quality, Michelle S. Repass

Theses and Dissertations

This exploratory study examines potential knowledge gaps in natural disaster preparedness across socioeconomic groups in Lee County, Alabama and identifies communication barriers affecting response behavior through the lens of the knowledge gap hypothesis. Survey data from 20 residents were analyzed using an objective socioeconomic status (OSES) score based on household income and highest level of education. Results indicate that while most respondents reported access to weather alerts and favorable behavioral responses that align with current guidelines from the National Weather Service, gaps are present in comprehension, response timing, and engagement in risky behavior that could delay protective action. Findings suggest …

Affects Of Ai In The Arts, Carolina D. Maldonado Faria

Theses and Dissertations

Art is an essential part of society, shaping culture, communication, and the digital world through forms such as music, writing, film, and animation. However, the rise of Artificial Intelligence (AI) has created conflict in the creative industry. Many AI systems are trained using artists’ works without consent, raising concerns about copyright infringement, intellectual property theft, and the loss of artistic value. While AI was originally intended as a tool for innovation, it now threatens artists’ careers and profits by imitating human creativity. This issue highlights the need for ethical regulations, stronger copyright protections, and fair compensation systems so AI and …

Edge Guided Channel Attention In Fsrcnn: A Novel Approach For Depth Super Resolution, Yagneshkumar Jayantilal Parmar, Paresh M. Dholakia

Mansoura Engineering Journal

Depth images from low-cost sensors often suffer from blurred edges and structural distortions when processed with standard super-resolution models. While FSRCNN is efficient for RGB images, it struggles to handle the unique geometric requirements of depth maps. To solve this, we propose the Edge Guided Channel Attention FSRCNN (EGCA FSRCNN). This method incorporates an edge-guided modulation mechanism to preserve object boundaries and a Squeeze and Excitation (SE) block to focus on critical structural features. A major benefit of this framework is the use of frozen, pretrained FSRCNN weights, which bypasses the requirement for retraining. Our evaluation on the UTKinect, Middlebury, …

Evaluating Soil And Plant Health In A Wide-Row Maize (Zea Mays L.) Production System Integrated With Perennial Cover Crops And Turkey (Meleagris Gallopavo), Sovika Bhattarai

All Graduate Theses, Dissertations, and Other Capstone Projects

In regions dominated by intensive maize (Zea mays L.) production systems, such as the US Midwest, sustainable agricultural practices such as cover crops and livestock integration are gaining interest for their potential to improve soil, plant, and environmental health. Traditionally, annual cover cropping systems (ACCs) have been used to maintain soil quality and crop performance without compromising ecosystem services. However, the high establishment and management costs of ACCs highlight the need for alternative approaches, such as perennial cover crops (PCCs). Grown as companion crops with maize, PCCs provide extended soil cover and can improve soil biochemical properties (e.g., total C …

Town Of Merrimack, Nh Annual Report 2025, Merrimack Town Representatives

Merrimack, NH Annual Reports

This is an annual report containing vital statistics for a town/city in the state of New Hampshire.

Evaluating The Factors That Contribute To Lack Of Engagement Of The People Within Community Forest Management Programs, Doraneli Ampudia Parras

Theses & ETDs

Ecosystem loss and degradation around the world are occurring at an alarming rate. This can negatively impact the people that rely on these ecosystems. Community Forest Management is a practice that has been recognized globally to help mitigate these impacts. Community Forest Management (CFM) provides a solution to restoring ecosystems and improving the quality of life of the local people. The different structures and strategies of CFM’s around the world can influence its effectiveness. Researchers have identified several factors that can hinder CFM effectiveness. A crucial factor is participation from the local people. Active participation and support from local people …

An Examination Of Potential Mechanisms Underlying Muscle Memory, Santiago González-Quintero

Theses & ETDs

"Muscle memory is generally understood as the mechanism that supports the execution of a motor task during retraining following an initial period of both training and detraining. It can be found in the central nervous system where commands are being sent to accomplish a motor task; however, evidence exists for another type of memory within the myofiber itself. Through the analysis of data from animal and human exercise studies, this thesis examines the notion of muscle memory at different locations proximal to and/or within muscle, including the evidence for and feasibility of myonuclear permanence as a mechanism underlying muscle memory. …

Eat My Love:Finding Truth In Fairytales Through Filmmaking, Calypso Camacho

Theses & ETDs

This thesis is both a creative project and a critical investigation into the dissolving boundary between art shaping life and life shaping art in filmmaking. The creative project at its center is EAT MY LOVE, a short film adaptation of the Russian folk tale The Maiden Tsar (Царь-Девица). It is a fairytale set in the modern world that uses elements of surrealism and magical realism, and unexpectedly became a camouflaged documentary. Paralleling EAT MY LOVE’s storytelling rhythm, this thesis is divided into three segments: pre-production, production, and post-production. Each segment documents the corresponding step in the filmmaking process and explores …