Digital Commons Network^™

Cold Atmospheric Plasma For Prostate Cancer Therapy—Potential For Clinical Translation, Shengxin Zhang, Janith Wanigasekara, Daniela Boehm, James F. Curtin, Paula Bourke, Tao Zhang, Gemma K. Kinsella

Research Outputs: 2025-Present

Cold atmospheric plasma (CAP) has potential as a new cancer treatment tool due to its room temperature biocompatibility and possible cancer cell selectivity with low side effects. This review examines the current research stage of CAP therapy for Prostate Cancer (PCa) treatment with a focus on CAP device standardization and CAP therapy clinical translation. The current CAP preclinical data is explored through the lens of PCa cellular response, PCa cells selectivity, CAP treatment type and CAP combination therapies. Finally, building on the current preclinical data, this review proposes the potential clinical application methods of CAP at different PCa stages to …

Optimal Murine Cd4+ T Cell Priming By Mrna-Lipid Nanoparticle Vaccines Requires Endogenous Antigen Processing, Julia E. Rood, Suh Kyung Yoon, Mary K. Heard, Stephen D. Carro, Emma J. Hedgepeth, Mary E. O'Mara, Michael J. Hogan, Nhu Le, Hiromi Muramatsu, Kieu Lam, Petra Schreiner, Coral Kasden, Hansell H. Stedman, Ryan A. Langlois, James Heyes, Norbert Pardi, Laurence C. Eisenlohr

College of Life Sciences Faculty Papers

Lipid nanoparticle (LNP)-encapsulated nucleoside-modified mRNA vaccines elicit robust CD4+ T cell responses, yet the mechanisms underlying this T cell priming remain unknown. Antigens presented to CD4+ T cells on major histocompatibility complex class II (MHC II) are traditionally acquired by antigen presenting cells (APCs) from extracellular sources. Here we show that vaccine specific CD4+ T cell responses instead rely on antigen directly expressed within APCs, without extracellular transit. Murine APCs treated with mRNA-LNP vaccines activate T cells more efficiently when presenting antigen produced internally, rather than acquired externally. Immunization with mRNA-LNP vaccines engineered to inhibit antigen expression in APCs results …

Institutional Practices Drive Antibiotic Variability In Neonatal Intensive Care Units: Baseline Evidence To Inform National Stewardship Interventions In Oman, Abdullah Alqayoudhi, Manoj Malviya, Sathiya Murthi, Mohammed Rasik Nv, Adil Said Al-Wahaibi, Raya Al-Habsi, Said Al-Balushi, Talal Alwardi, Agha Hatif Shamsi, Halah Bait Raidan, Aamera Al-Majrafi, Preethi Kiran, Eyad Hani Abu Abu Alhaijaa, Kawther Al Amri, Khalfan Al Abdali, Mohammed S. Al Reesi, Nasser Al-Shafouri, Amal Al-Jabri, Sachin Shah, Said Al-Kindi, Zubair H. Aghai, Mohammed Al-Yahmadi, Amal Al-Maani

Department of Pediatrics Faculty Papers

Background: Antibiotic overuse in Neonatal Intensive Care Units (NICUs) is a major contributor to antimicrobial resistance and adverse neonatal outcomes. This study aims to evaluate baseline antibiotic utilization (AU), identify factors influencing variability, and assess the impact of neonatal characteristics and sepsis incidence. Methods: A multicenter retrospective analysis examined AU in seven NICUs from 2019 to 2023, involving 25,532 neonatal admissions during national antibiotic stewardship program implementation. Data encompassed neonatal clinical parameters, sepsis incidence, and AU metrics, including days of therapy (DOT) per 1000 patient-days. Statistical analyses included correlation assessments and multivariate regression to identify determinants of antibiotic use. Results: …

Menagerie: Animals In Art From The Kam Collection, Kruizenga Art Museum, Lisa Barney

Kruizenga Art Museum Posters

A poster for the exhibition Menagerie: Animals in Art from the KAM Collection held January 16–May 16, 2026.

Kruizenga Art Museum Online Collection - Exhibition Gallery

A Programmable Genetic Platform For Engineering Noninvasive Biosensors, Asish N Chacko, Kaamini M Dhanabalan, Jinyang Wan, Roy Chien, Nolan T Anderson, Binzhi Xu, Katie Pham, Ritu Tiwari, Arnab Mukherjee

Faculty, Staff and Student Publications

Creating genetic sensors for noninvasive visualization of biological activities in optically opaque tissues holds immense potential for basic research and the development of genetic and cell-based therapies. Magnetic resonance imaging (MRI) stands out among deep tissue imaging methods for its ability to generate high-resolution images without ionizing radiation. However, the adoption of MRI as a mainstream biomolecular technology has been hindered by the lack of adaptable methods to link molecular events with genetically encodable contrast. Here, we introduce modular aquaporin-based protease-activatable probes for enhanced reporting (MAPPER), a platform for the systematic creation of genetic sensors for MRI. To develop MAPPER, …

4-H Presents Multimedia Pilot 2026, Alison Coleman

UNH Cooperative Extension

No abstract provided.

Rare Heterozygous De Novo Variants In Rapgef2 Are Associated With A Neurodevelopmental Disorder, Ali H Bereshneh, Kirkland A Wilson, Xueyang Pan, Shabab B Hannan, Megan A Cooper, Jullianne Diaz, Eyby Leon, Tiana M Moses, Mahshid S Azamian, Daryl A Scott, Ping Yee Billie Au, Juan Pablo Appendino, Ingrid E Scheffer, Antony Kaspi, Melanie Bahlo, Michael S Hildebrand, Angela T Morgan, Ekanem Ekure, Joshua M Shulman, Friedhelm Hildebrandt, Jennifer E Posey, Paul Kruszka, Eric Vilain, Shinya Yamamoto, Oguz Kanca, Seth Berger, Hugo J Bellen

Duncan NRI Faculty and Staff Publications

Purpose: RAPGEF2 encodes a guanine nucleotide exchange factor (GEF) that activates small GTPases and has not been linked to a Mendelian disorder. RAPGEF2 is highly intolerant to loss-of-function variants. We report 5 de novo heterozygous variants in RAPGEF2 in unrelated individuals with developmental delay, attention deficit hyperactivity disorder, epilepsy, dysmorphic features, or other manifestations. We used a Drosophila model to assess the functional impact of the identified human variants.

Methods: We generated a Kozak-GAL4 null allele of the Drosophila ortholog of RAPGEF2, PDZ-GEF, and used the allele to determine the gene expression pattern as well as the loss-of-function phenotypes. We …

Glutamatergic Projection Neurons In The Basal Forebrain Underlie Learned Olfactory Associational Valence Assignments, Pey-Shyuan Chin, Zhuokun Ding, Mikhail Kochukov, Snigdha Srivastava, Elizabeth H Moss, Qingchun Tong, Benjamin R Arenkiel

Faculty, Staff and Student Publications

Sensory perception is shaped by experience, giving stimuli behavioral significance. Basal forebrain (BF) cholinergic neurons in mice, which are crucial for arousal and motivation, also regulate sensory processing. Within BF nuclei, glutamatergic (vGlut2BF) neurons receive cholinergic input and modulate behaviors, but their roles in encoding sensory significance remain unclear. Using in vivo calcium imaging, we found that vGlut2BF neurons initially poorly encoded odor identity. However, their response to conditioned odors increased following associative learning, and their population activity more distinctly encoded paired stimuli, reflecting emergent value representation. Furthermore, pairing stimulation or inhibition of vGlut2BF neurons with specific odors altered odor …

Role Of The Etv5/P38 Signaling Axis In Aggressive Thyroid Cancer Cells, Jerry H Houl, Rozita Bagheri-Yarmand, Muthusamy Kunnimalaiyaan, Paola Miranda Mendez, Joseph L Kidd, Ali Dadbin, Andrea Ruiz-Jurado, Parag A Parekh, Ying C Henderson, Nikhil S Chari, Aatish Thennavan, Reid T Powell, Clifford C Stephan, Xiao Zhao, Anastasios Maniakas, Roza Nurieva, Naifa L Busaidy, Maria E Cabanillas, Ramona Dadu, Mark Zafereo, Jennifer R Wang, Stephen Y Lai, Marie-Claude Hofmann

Faculty, Staff and Student Publications

Patients with poorly differentiated thyroid cancer (PDTC) and anaplastic thyroid cancer (ATC) face a much poorer prognosis than those with differentiated thyroid cancers. Around 25% of PDTCs and 35% of ATCs carry the BRAFV600E mutation, which constitutively activates the MAPK pathway, a key driver of cell growth. Although combining BRAF and MEK inhibitors can shrink tumors, resistance often develops. The exact cause of this resistance remains unclear. We previously found that in PDTC and ATC cells, the BRAFV600E mutation is strongly linked to the expression of ETV5, a transcription factor downstream of the MAPK pathway. In the current study, we …

Differential Blood-Brain Barrier Permeability Driven By Asymmetric Hypoperfusion In A Vascular Dementia Model, Mengjun Dai, Kuizhi Qu, Ying Jiang, Song Gao, Yan-Ning Rui, Zhen Xu

Faculty, Staff and Student Publications

Introduction: Blood-brain barrier (BBB) dysfunction has been associated with vascular dementia (VaD). However, the underlying mechanisms causing BBB dysfunction remain unclear, especially regarding cerebral hypoperfusion. This study aimed to investigate the effects of asymmetric hypoperfusion on BBB permeability using a mouse model of VaD.

Methods: Asymmetric bilateral common carotid artery stenosis (ACAS) was induced using ligature rings. BBB integrity was assessed on 3 days post-surgery using Evans blue, IgG, and albumin extravasation. A modified tissue processing protocol optimized endogenous marker detection. Regional and sex-based differences in BBB permeability were analyzed.

Results: Increased BBB permeability was observed in both corpus callosum …

Fun Reading, Study Breaks And Academic Support: The Perfect Blend For Building Sense Of Belonging, Kate Peterson, Lacie Mcmillin, Phil Dudas, Theresa Heitz

Navigating the Future Together: Student Success Symposium

With budget cuts to school libraries, a decline in reading, and an awareness that students’ lived experience in libraries can range from warm fuzzy feelings to seriously negative emotions, we created a new blend of undergraduate services programming deliberately mixing fun with academic support to support post-pandemic students.

Humanitarian Intervention: The Early Years, Nicholas Onuf

Florida Journal of International Law

No abstract provided.

The Good, The Bad And The Ugly: A Retrospective On Telos, Scott G. Mcnall

Fast Capitalism

No abstract provided.

The Editor, The Journal, The Project, Russell A. Berman

Fast Capitalism

No abstract provided.

Café Narcissism, Jamie Dangler, Mark P. Worrell

Fast Capitalism

The 1979 Cortland Conference marked a decisive shift in the adventures of Telos by opening up a debate on narcissism that would pave the way for later contests that, in turn, symbolize in the eyes of many, the errant swerve of Marxism and post-Marxist critical theory. In what follows we examine the vibrant theoretical community at Cortland during the late-70s and early 80s, revisit the conference itself, and reflect on the narcissism concept and its relationship to anti-capitalist struggle in a way that is both attuned to debates surrounding the 1979 conference as well as its ongoing relevance for critical …

Absolutizing The Particular, Robert J. Antonio

Fast Capitalism

From the late-1960s to the mid-1980s, Telos brought the Frankfurt School, Western Marxism, and other critical Continental thought to North America and the English speaking world; it was the critical theory organ of that era and best ever English language journal on the topic. Its left lean did not compromise its critical view of communist regimes and left-wing parties and thinkers. Its contribution with regard to critical theories, with Hegelian-Marxist roots, was so substantial and widely acknowledged that many former readers and, I expect, even some journal editors, who have advertised in Telos, during the last 25 years, did not …

Full Issue, Fast Capitalism Editorial Team

Fast Capitalism

No abstract provided.

Brain Gains: A Review Of Remediation Treatment Strategies Using Exercise Following Traumatic Brain Injury, Jessica Smith, Kristin Biggins, Loriann Helgeson

The Open Journal of Occupational Therapy

In this Opinions in the Profession article, we explore remediation treatment strategies using exercise for recovery from post-traumatic brain injury and aim to justify the use of such treatment in the occupational therapy profession to increase skills for functional gain. Common treatment strategies used by occupational therapists after brain injury are compensatory strategies, indicating the client learns a new way to perform the task. Though effective, it is also necessary to consider how remediation and neuroplasticity are essential. Teaching new approaches to complete tasks results in functional gains; however, focusing on foundational skills using exercises to relearn motor patterns to …

More Than Covering Ears: A Clinical Inventory For Characterizing Decreased Sound Tolerance (I-Dst) In Autism, Tana B. Carson, Angela Medina, Katherine L. Long, Yuxi Qiu, Monica Noriega

The Open Journal of Occupational Therapy

Background: Decreased sound tolerance (DST) is among the most common and distressing forms of sensory over-responsivity experienced by children with autism spectrum disorders. DST includes hyperacusis and misophonia, among others, and can limit participation in daily activities. Recently, a new screening tool, the Pediatric Hyperacusis and Misophonia Questionnaire (PMHQ-4) has been developed to allow health professionals to better identify and differentiate these conditions using a single assessment. Additional clinical tools are needed to further characterize DST symptoms to facilitate treatment planning after diagnosis.

Methods: In this mixed-methods study n = 15 parents of autistic children 6 to 17 …

Antimonopoly In The Air: Assessing Airline Deregulation, Elie Nehme

Tennessee Journal of Law and Policy

No abstract provided.

Issue 478 January 15, 2026, The Local Voice

The Local Voice

Special Issue: The Townies 2026. Featured Articles: "16th Clarksdale Film & Music Festival Brings Hollywood Excitement to the Delta."; "Obituary: Jeffrey Callaway. (February 20, 1963–January 10, 2026)."; "The Pinksheets: Chewed-Up Bubblegum with a Southern Kick."

Spectator 2026-01-15, Editors Of The Spectator

The Spectator

No abstract provided.

Las Representaciones Figurativas Del Sitio Arqueológico Cuidad Del Jaguar (Honduras): Espacio Sagrado, Conceptos Compartidos Y Diálogo Entre Mesoamérica Y La Zona Andina, Geydy Rodríguez Wood

Actas seleccionadas del SIMPOSIO ARTE 4.2: Migraciones en la imagen prehispánica: transitando territorios del pasado al presente. 58º Congreso Internacional de Americanistas, Novi Sad, Serbia, 2025.

El sitio arqueológico Ciudad del Jaguar-T1, se encuentra ubicado en el noroeste de Honduras. Pertenece al Área Intermedia, considerada zona de frontera y paso entre Mesoamérica y la Zona Andina. Esta ubicación facilitó que, durante la época prehispánica, fuese un sitio de migraciones e interacción constante entre culturas del norte y del sur del continente, que dio origen a una civilización hasta ahora desconocida, que se formó, desarrolló y tuvo una significativa producción artística. En el presente trabajo propongo el estudio y la lectura e interpretación de las imágenes figurativas representadas en los objetos excavados, como también su utilidad y …

Aves, Felinos Y Ofidios En Los Templos Montaña Amerindios, Sarai Ramos Muñoz

Actas seleccionadas del SIMPOSIO ARTE 4.2: Migraciones en la imagen prehispánica: transitando territorios del pasado al presente. 58º Congreso Internacional de Americanistas, Novi Sad, Serbia, 2025.

El siguiente estudio se centra en la comparación de las representaciones pictóricas de aves, felinos y ofidios de algunos de los principales Templos Montaña, tanto de la zona andina, como de Mesoamérica. Dentro de él se pueden apreciar las similitudes y diferencias arquitectónicas y escultóricas simbólicas de estas imágenes. El análisis comparativo se realiza a través de un estudio iconográfico e iconológico de la arquitectura escultórica de dichos templos y de cada una de las representaciones zoomorfas relacionadas con el concepto del Axis Mundi prehispánico, centrándose en el águila, el jaguar y la serpiente. Al mismo tiempo se analiza la …

Bi-Allelic Variants In Bcat1 Impair Mitochondrial Function And Are Associated With A Candidate Neurometabolic Disorder., Brianna L Disanza, Giulia S Porcari, Livia Sertori Finoti, Leonardo Ramos-Rodriguez, Devin M Burris, Justin A Mcdonough, Gang Ning, Grace Fagan, Guy T Helman, Erin Weiss, Ryan J Taft, Amy Pizzino, Matthew T Whitehead, Amy Waldman, Cas Simons, Xilma Ortiz-Gonzalez, William C Skarnes, Adeline Vanderver, Elizabeth J Bhoj, Rebecca C Ahrens-Nicklas

Faculty Research 2026

Branched-chain amino acid transaminase-1 (BCAT1) initiates the catabolism of branched-chain amino acids (BCAAs), which are essential for neurologic function. However, the role of BCAT1 in neurodevelopment is largely unknown. Here, we identify compound heterozygous BCAT1 variants in a patient with a severe progressive neurodevelopmental syndrome. To investigate the functional consequences, we established patient variant (BCAT1: c.792T>A p.Phe264Leu; c.1042G>A p.Glu348Lys) and BCAT1 knockout hiPSC models. Both disease models show profound defects in cortical neuron differentiation and neurite outgrowth. Furthermore, metabolic analysis revealed evidence of mitochondrial dysfunction associated with increased levels of tricarboxylic acid (TCA) cycle intermediates, glutamate, and glutamine. …

Research Progress In Antagonistic Bacteria Against Staphylococcus Aureus, Caiqi Wang, Yuansong Ma, Xinrui Zhao, Pei Zhou, Sifan Lu, Yuxin Li, Yinbiao Xu

Journal of Food Science and Biotechnology

Staphylococcus aureus,a common Gram-positive foodborne pathogen,is ubiquitous in the human skin and respiratory tract.It can cause pneumonia,pleurisy,endocarditis,food poisoning,sepsis and other infectious diseases.The widespread and long-term use of antibiotics has aggravated the antibiotic resistance of Staphylococcus aureus.In particular,the emergence of multi-drug resistant strains has greatly reduced the therapeutic effect.Therefore,developing new antibacterial means to replace or assist existing antibiotics has become an urgent need.Microbial natural products are important resources for the development of new antibiotics,and antagonistic microorganisms play an important role.This paper reviewed the species of antagonistic bacteria against Staphylococcus aureus,the types of antibacterial active substances,and the commonly used screening methods of …

Cyanidin- 3-Glucoside Ameliorates Ocular Surface Dysfunction In Rats With Dry Eye Disease, Ke Zhang, Ziyu Liu, Zhangben Yao, Peng Zhang, Lei Tian, Ying Jie, Yong Wang

Journal of Food Science and Biotechnology

[Objective ] Studies have shown that cyanidin- 3-glucoside (C3G),the main component of black rice anthocyanins,exhibits protective effects on retina and retinal pigment epithelium (RPE ) cells.However,there is a lack of in vivo evidence regarding the efficacy of C 3G in alleviating dry eye disease (DED ),which limits its application in ocular surface disorders.This study aims to investigate the protective effects of C 3G on DED in rats.[Method ] 24 Wistar rats were randomly assigned into control,model,and C 3G groups.In model and C 3G groups,a DED model was established by subcutaneous injection of scopolamine hydrobromide (4 times daily for 28 d).The …

Ultrasound-Assisted Enzymatic Transformation And Immune Efficacy Of Black Ginseng Saponins, Kuo Wang, Bao Zhong, Mingran Luan, Fenglin Li, Zhongkui Lu, Guanran Wang, Kun Yao

Journal of Food Science and Biotechnology

[Objective ] This study aims to elucidate the transformation process of black ginseng saponins and their immunomodulatory mechanisms.[Method ] An ultrasound-assisted enzymatic method was employed for the transformation of black ginseng saponins,and the mass concentration of black ginseng saponins was determined.Furthermore,the immunomodulatory effects of black ginseng saponins were investigated through animal experiments.[Result ] Under the conditions of an enzymatic hydrolysis temperature of 40 ℃,an enzyme mass fraction of 8%,enzymatic hydrolysis time of 60 min,and ultrasonic treatment time of 25 min,the mass concentration of black ginseng saponins increased from 1 615.40 μg/mL to 3 351.38 μg/mL,which represented an increase of 107.47%.The …

Degradation Of Nutrients In Corn Steep Liquor By Aspergillus Oryzae And Absorption Characteristics Of The Product, Xiaojie Wang, Chunrong Xia, Xiaolan Liu

Journal of Food Science and Biotechnology

[Objective ] This study aims to explore the degradation patterns of nutrients in corn steep liquor by Aspergillus oryzae and the absorption characteristics of the product.[Method ] Aspergillus oryzae was used for the fermentation of corn steep liquor,and degradation patterns of nutrients were studied after fermentation for 1,3,5,7,9,and 11 d.Changes in amino acid mass fraction and peptide molecular mass distribution in corn steep liquor after fermentation for 7 d were measured.Furthermore,the resting cells of Auricularia heimuer mycelia were used to explore the absorption characteristics of the fermentation product of corn steep liquor.[Result ] As the fermentation time prolonged within 1~7 …

Nitrogen Dynamics And Use Efficiency In Pasture-Based Grazing Systems: A Synthesis Of Ecological And Ruminant Nutrition Perspectives, Bashiri Iddy Muzzo

Wildland Resources Student Research

Pasture-based ruminant systems link nitrogen (N) nutrition with ecosystem N cycling. Grazing ruminants convert fibrous forages into milk and meat but excrete 65 to 80% of ingested N, creating excreta hotspots that drive ammonia volatilization, nitrate leaching, and nitrous oxide (N₂O) emissions. This review synthesizes ecological and ruminant nutrition evidence on N flows, emphasizing microbial processes, biological N₂ fixation, plant diversity, and urine patch biogeochemistry, and evaluates strategies to improve N use efficiency (NUE). We examine rumen N metabolism in relation to microbial protein synthesis, urea recycling, and dietary factors including crude protein concentration, energy supply, forage …