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Articles 10711 - 10740 of 14349
Full-Text Articles in Entire DC Network
A Bovine Cell Line Resistant To Japanese Encephalitis Virus Entry But Permissive To Post-Entry Replication, Sang-Im Yun, Young-Min Lee
A Bovine Cell Line Resistant To Japanese Encephalitis Virus Entry But Permissive To Post-Entry Replication, Sang-Im Yun, Young-Min Lee
Animal, Dairy, and Veterinary Science Faculty Publications
Japanese encephalitis virus (JEV) is a mosquito-borne zoonotic orthoflavivirus that poses a significant global health threat. It causes severe neuroinflammatory disease in humans and reproductive failure in swine. Because of the broad host range and cell tropism of JEV, identifying animal cell lines resistant to infection has been a persistent challenge. In this study, we demonstrate that Madin–Darby bovine kidney (MDBK) cells are resistant to JEV infection yet remain fully permissive to viral replication when transfected with viral genomic RNA. Using immunoblotting, immunofluorescence, and flow cytometry, we show that MDBK cells, unlike the highly susceptible baby hamster kidney (BHK-21) cells …
Myd88 Signaling In Myeloid Cells Induces Gastrointestinal Tract Injury And Systemic Inflammation After West Nile Virus Infection, Shih-Ching Lin, Fang R Zhao, Matthias Mack, Gabriel Mbalaviele, Michael S Diamond
Myd88 Signaling In Myeloid Cells Induces Gastrointestinal Tract Injury And Systemic Inflammation After West Nile Virus Infection, Shih-Ching Lin, Fang R Zhao, Matthias Mack, Gabriel Mbalaviele, Michael S Diamond
2020-Current year OA Pubs
Humans with autoantibodies to type I interferons (IFNs) are at higher risk for neurological disease after West Nile virus (WNV) infection. IFN signaling deficient WNV-infected mice develop greater inflammation in the brain, which correlates with loss of gut barrier integrity. Here, we investigate the immune pathways that mediate this virus-gut-brain axis of inflammation. Myd88
Dual Roles Of Trpv2 In The Innate Immune Response To Cytosolic Dna: Arresting Dormant And Boosting Activated Sting, Chen Cheng, Hsiang-Ting Lu, Shan Li, Zhongsheng You
Dual Roles Of Trpv2 In The Innate Immune Response To Cytosolic Dna: Arresting Dormant And Boosting Activated Sting, Chen Cheng, Hsiang-Ting Lu, Shan Li, Zhongsheng You
2020-Current year OA Pubs
The cGAS/STING-dependent innate immune pathway is central in the cellular response to cytosolic DNA derived from viral infections, genotoxic stress, or mitochondrial defects. While efficient activation of the pathway is crucial for defending against pathogens and cancer, maintaining its dormancy without stimuli is equally important to avoid autoimmunity. However, the precise control of the cGAS/STING pathway remains poorly understood. Here, we report that the ion channel TRPV2 regulates both the dormancy and activation of STING. TRPV2 associates with STING and suppresses spontaneous STING activation in the absence of cytoDNA but dissociates from STING and promotes its activation by releasing Ca
Seizure Presentation Of A Grade Ii Astrocytoma In A Patient With Ollier's Disease: A Case Report And Brief Review, Marissa Vail, Hunter Slosser, Robert Steele, Brian Curtis, Daniel Henry
Seizure Presentation Of A Grade Ii Astrocytoma In A Patient With Ollier's Disease: A Case Report And Brief Review, Marissa Vail, Hunter Slosser, Robert Steele, Brian Curtis, Daniel Henry
Student Publications
Ollier's disease (enchondromatosis) is a dysplasia of cartilage characterized by multiple enchondromas. Current evidence supports a measurable prevalence of concurrent gliomas in patients with Ollier's disease. In patients with Ollier's disease, isocitrate dehydrogenase 1 (IDH1) and isocitrate dehydrogenase 2 (IDH2) mutations were shown to be a predisposing factor to the development of astrocytomas in conjunction with subsequent mutations in adenosine triphosphate (ATP)-dependent helicase ATRX (ATRX) and tumor protein p53 (TP53). We present the case report of a 21-year-old man with an adolescent diagnosis of Ollier's disease who developed a grade II astrocytoma in early adulthood. The patient presented to the …
Systemic Drug Delivery In Pigs Using Biodegradable Microneedle Patches, Katherine A. Miranda-Munoz, Tsungcheng Tsai, Jacy Riddle, Ke He, Lee Blaney, Jeremy Powell, Jorge Almodovar
Systemic Drug Delivery In Pigs Using Biodegradable Microneedle Patches, Katherine A. Miranda-Munoz, Tsungcheng Tsai, Jacy Riddle, Ke He, Lee Blaney, Jeremy Powell, Jorge Almodovar
Biomedical Engineering Faculty Publications and Presentations
Transdermal microneedle systems offer a minimally invasive strategy for systemic drug delivery in veterinary medicine. In this study, biodegradable microneedle patches composed of polyvinyl alcohol, collagen, and chitosan were evaluated in pigs for the delivery of two model compounds, fluorescein isothiocyanate-dextran (FITC-dextran, 4 kDa) and flunixin meglumine (FLU). Patches were applied to the ear and neck to assess the influence of anatomical site on systemic absorption. FITC-dextran delivered via a single 50 mg patch on the neck achieved approximately 1.2-1.4-fold higher plasma concentrations than oral administration and ear-applied patches, demonstrating enhanced uptake from vascularized regions. FLU patches applied to the …
Coexisting Salps Exhibit Distinct Feeding Selectivity On Microorganisms In The North Pacific Subtropical Gyre, Anne W. Thompson, Kylee Lamberson, Kelly R. Sutherland
Coexisting Salps Exhibit Distinct Feeding Selectivity On Microorganisms In The North Pacific Subtropical Gyre, Anne W. Thompson, Kylee Lamberson, Kelly R. Sutherland
Biology Faculty Publications and Presentations
Mortality mechanisms play an important role in how oceanic microorganisms contribute to global biogeochemical cycles. Salps are widespread pelagic tunicates known to remove phytoplankton from coastal and high-latitude waters, but their interaction with microorganisms in the vast tropical and subtropical gyres is not well quantified. Using quantitative measurements of six major marine microorganisms in the guts of six distinct but co-occurring salp species from the North Pacific Subtropical Gyre, we examined the impact and dynamics of salp feeding on marine microorganisms in a vast open ocean region. All salps preferentially removed prey greater than 1 μm in diameter, including marine …
Distinct Contributions Of Etv2+ And Flk1+ Progenitors To Endothelial, Hematopoietic, And Cardiac Lineages, Dereck Alleyne, Minseo Kim, Jun Wu, Yoojung Kwon, Ye-Ram Kim, Ashraf Ul Kabir, Matthew Ishahak, Jeffrey R Millman, Changxu Fan, Hyung Joo Lee, Karen Krchma, Xiaoyun Xing, Kory Lavine, Ting Wang, Kyunghee Choi
Distinct Contributions Of Etv2+ And Flk1+ Progenitors To Endothelial, Hematopoietic, And Cardiac Lineages, Dereck Alleyne, Minseo Kim, Jun Wu, Yoojung Kwon, Ye-Ram Kim, Ashraf Ul Kabir, Matthew Ishahak, Jeffrey R Millman, Changxu Fan, Hyung Joo Lee, Karen Krchma, Xiaoyun Xing, Kory Lavine, Ting Wang, Kyunghee Choi
2020-Current year OA Pubs
The ETS family transcription factor ETV2, VEGFA, and its receptor FLK1 are essential for hematopoietic, vascular, and cardiac development. Here, we combine dual Etv2 and Flk1 lineage tracing with molecular profiling to define how mesoderm progenitors are allocated to hematopoietic, endothelial, cardiomyocyte, and smooth muscle lineages. We demonstrate that hematopoietic, endothelial, and cardiac valves arise from dual Etv2
Ablation Of Cd38 In Multiple Myeloma Cells Leads To An Aggressive Phenotype In A Mouse Xenograft Model, Michael R Dyer, Alex Zheleznyak, Erin N Teubner, Julie L Prior, Brad Manion, Zhenghan Jing, Amit K Sharma, Junwei Du, Rui Tang, Mark A Fiala, John F Dipersio, Deborah Veis, Julie O'Neal, Mikhail Y Berezin, Monica Shokeen
Ablation Of Cd38 In Multiple Myeloma Cells Leads To An Aggressive Phenotype In A Mouse Xenograft Model, Michael R Dyer, Alex Zheleznyak, Erin N Teubner, Julie L Prior, Brad Manion, Zhenghan Jing, Amit K Sharma, Junwei Du, Rui Tang, Mark A Fiala, John F Dipersio, Deborah Veis, Julie O'Neal, Mikhail Y Berezin, Monica Shokeen
2020-Current year OA Pubs
Multiple myeloma (MM) is a plasma cell malignancy characterized by bone pain and end-organ failure. A major challenge in treating MM is therapeutic resistance. CD38-targeted immunotherapies, such as daratumumab, have significantly improved outcomes; however, variable responses, resistance, and relapse remain vital challenges. We hypothesized that loss of CD38 drives a more aggressive phenotype and resistance to therapy. To test this, we developed a CD38 knockout (KO) clone of a human MM cell line and evaluated it in immunodeficient mice. Mice with CD38 KO tumors exhibited an increased tumor burden and reduced survival compared with those with CD38 wild-type (WT) tumors. …
Inducible Deletion Of Dgat1 And 2 From Microglia Exacerbates Neurodegeneration And Endolysosomal Lipid Accumulation In Male Ps19 Mice, G Travis Tabor, Alexandra Litvinchuk, Yun Chen, Austin Allison, Carisa Zeng, Hao Hu, Peter B Lin, Prabal Sharma, Samira Parhizkar, Sihui Song, Xin Bao, Abhirami K Iyer, Shih Feng You, Javier Remolina Serrano, Melissa Manis, Emily Franke, Anil G Cashikar, Carla M Yuede, Celeste M Karch, Eric J Huang, Maxim Artyomov, Jason D Ulrich, David M Holtzman, Et Al.
Inducible Deletion Of Dgat1 And 2 From Microglia Exacerbates Neurodegeneration And Endolysosomal Lipid Accumulation In Male Ps19 Mice, G Travis Tabor, Alexandra Litvinchuk, Yun Chen, Austin Allison, Carisa Zeng, Hao Hu, Peter B Lin, Prabal Sharma, Samira Parhizkar, Sihui Song, Xin Bao, Abhirami K Iyer, Shih Feng You, Javier Remolina Serrano, Melissa Manis, Emily Franke, Anil G Cashikar, Carla M Yuede, Celeste M Karch, Eric J Huang, Maxim Artyomov, Jason D Ulrich, David M Holtzman, Et Al.
2020-Current year OA Pubs
Brain myeloid cells accumulate neutral lipids in multiple human neurodegenerative disorders and relevant mouse models. These lipids are often assumed to be contained in lipid droplets (LDs). While studies have been performed in cell culture and Drosophila models to characterize glial LDs, the roles of microglial LD biogenesis in mammalian tauopathy are unclear. To address this issue, we induced the deletion of diacylglycerol acyltransferases (DGATs) 1 and 2, enzymes critical for LD formation, from microglia in the PS19 mouse model of tauopathy. Microglial DGAT double knockout (KO) exacerbated neurodegeneration and increased the abundance of brain cholesteryl esters in male PS19 …
Thinking Otherwise With Children In Cities: A Storying Approach To Co-Researching With Children And Teachers, William A. Parnell, Sally Guyon
Thinking Otherwise With Children In Cities: A Storying Approach To Co-Researching With Children And Teachers, William A. Parnell, Sally Guyon
Leadership, Learning and Counseling Faculty Publications and Presentations
This Children in Cities research project examines an approach to storying research that foregrounds collaborative meaning-making between educators and young children in their city. Through exploring how educators and young children might “think otherwise” about teaching, learning, and participation with history, Place noticing and entanglements between humans, more-than-human, and non-humans, three stories and a metaphor surface in the data. Drawing on three stories, metaphor is employed as an analytic and integrative device to deepen interpretation of lived experiences. Central to the methodology is a democratic orientation that seeks to reduce hierarchical boundaries, engaging children aged 3–5 as co-researchers in the …
Mechanical Performance Evaluation Of Natural Composites Recycled Hemp Rice Bag Reinforced With And Without Silicon Carbide Particles, Gaber A. Elawadi, A. S. Fayed
Mechanical Performance Evaluation Of Natural Composites Recycled Hemp Rice Bag Reinforced With And Without Silicon Carbide Particles, Gaber A. Elawadi, A. S. Fayed
Mansoura Engineering Journal
Significant progress has been made in the development of natural fiber-reinforced composite materials, owing to their potential to enhance mechanical properties while offering a greener and more sustainable alternative to traditional materials. These materials combine superior ecological benefits with enhanced mechanical performance. This study examines how recycled hemp fiber bags, including recycled hemp fibers obtained from rice hemp fiber bags, affect the mechanical characteristics of unreinforced and reinforced composites. Four composite systems were fabricated and tested: (1) HFR (randomly chipped recycled hemp fiber bags–epoxy composite), (2) HFB (continuous recycled hemp fiber bag–epoxy composite), (3) HFR SiC (randomly chipped recycled hemp …
A Constructive-Engaging Analysis Of Descarrtes (European) And Oyeshile (African) On Personhood, Olanrewaju Shitta-Bey
A Constructive-Engaging Analysis Of Descarrtes (European) And Oyeshile (African) On Personhood, Olanrewaju Shitta-Bey
Comparative Philosophy
An examination of the nature of the human person provides a crucial foundation for understanding human life and identity. Conceptions of personhood have far-reaching implications beyond philosophy, influencing politics, ethics, religion, and epistemology. Beliefs about what constitutes a person shapes theories of rights, responsibility, and justice; moral views on duty and accountability; religious understandings of the soul and the afterlife; and epistemological reflections on the sources and limits of knowledge. Inquiry into human nature is therefore not merely abstract, but central to understanding social organization and individual conduct. This paper examines two influential accounts of human nature drawn from distinct …
Father Knows Best? Not Here: Metaphors Of Kinship And Kingship In Haudenosaunee, Aristotelian, And Confucian Political Thought, Ian Kalman
Comparative Philosophy
The notion that the organization of large-scale social structures are rooted in domestic ones has a longstanding history in both Chinese and Greek classical political philosophy. Aristotle and Confucius independently reasoned that a good family, one with a strong father, mapped onto a good state, one with a strong king - though they differed on the details. While there is a strong literature juxtaposing these two titans, less attention has been paid to how their ideas compare with other philosophical traditions. This article provides an anthropological intervention to the comparative study of Confucius and Aristotle – while both autonomously argued …
The Coherence Of Navayāna Pragmatism: Ambedkar And The Pragmatist Reconstruction Of Buddhist Philosophy, Danish Hamid
The Coherence Of Navayāna Pragmatism: Ambedkar And The Pragmatist Reconstruction Of Buddhist Philosophy, Danish Hamid
Comparative Philosophy
This paper examines the philosophical coherence of B.R. Ambedkar’s reconstruction of his (Navayāna) Buddhism in relation to John Dewey’s pragmatism. Building on Scott Stroud’s reading of Ambedkar as a Deweyan Pragmatist (2017, 2023), it argues that Dewey’s evolutionary naturalism, his conception of growth, and pragmatic redefinition of concepts provide Ambedkar with the methodological tools for a naturalistic and socially reconstructive reinterpretation of Buddhist doctrines such as anicca (impermanence), dhamma (Buddha’s teaching), nirvāṇa (enlightenment), karuna (compassion), etc. Ambedkar transforms impermanence from a metaphysics of flux into an ethics of progressive growth, and recasts dhamma as a social morality grounded in fraternity …
Profile: John Mcphee, Michael Pearson
Profile: John Mcphee, Michael Pearson
Creative Nonfiction Magazine
No abstract provided.
Pilgrims, Philip Garrison
How Tununak Came To Me, Carolyn Kremers
How Tununak Came To Me, Carolyn Kremers
Creative Nonfiction Magazine
No abstract provided.
Bush Taxi Commandos, Peter Chilson
Divining Domination: Steve Bannon As A Political Mystagogue, Tony Allen Feldmann
Divining Domination: Steve Bannon As A Political Mystagogue, Tony Allen Feldmann
Fast Capitalism
Right-wing commentators (on tv, radio, newspapers, documentaries, or the internet) are often considered a source of misinformation and radicalization in American politics. Understanding the role of such commentators in the political sphere has taken on new significance since the election of Trump, who regularly takes talking points as well as political advice from prominent figures in right-wing media. The purpose of these political "shock jocks" also extends beyond mere political commentary: They offer their audience a framework for understanding the world. This framework contains certain reified perceptions of society and history. Durkheim and those working in his tradition have long …
Hamlet's Father: Hauntology And The Roots Of The Modern Self, Lukas Szrot
Hamlet's Father: Hauntology And The Roots Of The Modern Self, Lukas Szrot
Fast Capitalism
In his 1949 work Hamlet's Ghost, Richard Flatter wrote of the ghost of Hamlet's father that the play ultimately belongs to him, to the ghost. Modernity, like the play, belongs to its ghosts, to its dead fathers haunting their wayward sons, the metaphysical specters it imperfectly endeavors to exorcise. Critical theory has often focused on the possibility, and the contours, of a utopia populated by liberatory spirit and liberated persons. Less well explored, however, are the implications for tradition, religion, and the transmission of culture at a metaphorical echelon—those ostensibly "pre-modern" ideas which the broader project of Enlightenment liberalism never …
Shakespeare's Plays Of Deranged Authority: The King's Three Bodies, Daniel Krier
Shakespeare's Plays Of Deranged Authority: The King's Three Bodies, Daniel Krier
Fast Capitalism
Shakespeare's plays are situated upon the threshold of two worlds: a declining traditional order torn apart by political rivalry and ascendant early-modern capitalism. The history plays dramatize infighting among warring factions of privileged aristocrats as well as revolutionary forces propelled by the rising commons and the politics of commodity. Legitimate authority is rarely secure among the kings perched upon Shakespearean thrones. In Shakespeare's Henriad and King John, crowns are contested from the moment they are placed upon royal heads, inspiring Kantorwicz's political theology: the corporeal body of short-lived kings is distinct from the sovereign's sublime body that reigns without cease. …
The Master's Race: Phallic Whiteness In "The Young Savages", Graham Cassano
The Master's Race: Phallic Whiteness In "The Young Savages", Graham Cassano
Fast Capitalism
This essay examines two parallel, historically contemporaneous, depictions of the Freudian master-slave dialectic. John Frankenheimer's first film, The Young Savages (1961), reconstructs Hank Bell's (Burt Lancaster) repressed transformation from Italian racial other into a white ethnic. In doing so, the film approaches the possibility that race itself may be a kind of social construction. To get at this notion, the film explores the meaning of race in an overtly psychoanalytic language. In fact, The Young Savages echoes the argument of Jacques Lacan's nearly contemporaneous essay, "The subversion of the subject and the dialectic of desire in the Freudian unconscious." Lacan's …
Ignoring Goethe's Faust: A Critical-Theoretical Perspective On American Ideology, Harry F. Dahms
Ignoring Goethe's Faust: A Critical-Theoretical Perspective On American Ideology, Harry F. Dahms
Fast Capitalism
The neglect of Goethe, his work in general, and Faust in particular, in English-speaking countries, is notorious. While Shakespeare's plays have been prominent and widely performed in German-speaking countries, the same is not true for Goethe in the English-speaking world. Focusing non-exclusively on Faust, and cutting a link to Thomas Mann's Doctor Faustus, I will endeavor to delineate problematic aspects of American ideology, and what it would take, within U.S. sociology, to be cognizant of the latter. Georg Lukacs wrote about Goethe and Faust, and so did Theodor W. Adorno and Leo Loewenthal, highlighting its importance to critical theory. The …
Have A Heart For The Holocene: The Politics Of Ark Activism, Collaborative Conservation, And Sponsored Survival At Museums, Timothy W. Luke
Have A Heart For The Holocene: The Politics Of Ark Activism, Collaborative Conservation, And Sponsored Survival At Museums, Timothy W. Luke
Fast Capitalism
No abstract provided.
The Tragedy Of The Commonplace: Clichés In The Age Of Copyright, Jakob Norberg
The Tragedy Of The Commonplace: Clichés In The Age Of Copyright, Jakob Norberg
Fast Capitalism
No abstract provided.
Writing Circuit Histories, Sascha Engel
Review Of "World War Zoos: Humans And Other Animals In The Deadliest Conflict Of The Modern Age" By John M. Kinder, Matthew Barrett
Review Of "World War Zoos: Humans And Other Animals In The Deadliest Conflict Of The Modern Age" By John M. Kinder, Matthew Barrett
Canadian Military History
Review of World War Zoos: Humans and Other Animals in the Deadliest Conflict of the Modern Age by John M. Kinder
Photocrosslinkable Morin-Loaded Gelatin-G-Gma Composite Hydrogel For Accelerating Burn Wound Healing: In Vitro And In Vivo Assessments, Samar A. Salim
Photocrosslinkable Morin-Loaded Gelatin-G-Gma Composite Hydrogel For Accelerating Burn Wound Healing: In Vitro And In Vivo Assessments, Samar A. Salim
Nanotechnology Research Centre
The impaired skin regeneration, scarring, and delayed healing make the management of burn injuries a challenging task. We designed a photopolymerized hydrogel of gelatin-grafted with glycidyl methacrylate (GMA) for burn management applications. Hydrogel was incorporated with Morin, a plant flavonoid that was originally isolated from the Moraceae family, with known anti-antioxidant and antifibrotic activities. The physicochemical characterization of the resultant hydrogel, including its gelation time and swelling properties, was conducted. The characterization results indicated that the hydrogel development was successful, exhibiting well-established porosity, as evidenced by the SEM images. In vivo evaluation demonstrated improved tissue regeneration characterized by enhanced collagen …
Exploring Opportunities With Global Citizenship Education: Practice, Frameworks, And Curriculum Renewal, Miguel Heilbron
Exploring Opportunities With Global Citizenship Education: Practice, Frameworks, And Curriculum Renewal, Miguel Heilbron
Consensus
No abstract provided.