Digital Commons Network^™

Wild Robots: Humans, Wilderness, And Technology In Becky Chambers’ Monk And Robot Series, Melissa Moore

Honors Theses

As technology advances and the environment deteriorates, the way people view the relationships between technology, wilderness, and humans becomes essential for society to move forward. To investigate perceptions about technology’s place in an environmentally conscious society, this project examines manifestations of wilderness/wildness and technology in Becky Chambers’ Monk and Robot series through the lens of ecocriticism. Using Timothy Morton's concept of the ecological thought as a framework for analysis, the circumstances present in the novel suggest that the triangle separating humans, wilderness, and technology has actually collapsed, replaced by an enmeshment of technology, wilderness, and humanity.

Franceschi V. Lg Chem, Ltd., 141 Nev. Adv. Op. 65 (Dec. 18, 2025), Eden Tesfay

Nevada Supreme Court Summaries

When there is a disconnect between a defendant’s contacts with the forum state and the harm alleged by the plaintiff, specific jurisdiction may not lie with the forum court.

Sankcja Kredytu Darmowego Jako Skutek Ryzyka Braku Zgodności W Zakresie Kontraktowych Obowiązków Informacyjnych W Umowach Kredytu Konsumenckiego – Kilka Wybranych Uwag Na Tle Interpretacji Art. 45 Ustawy O Kredycie Konsumenckim, Edyta Rutkowska-Tomaszewska

internetowy Kwartalnik Antymonopolowy i Regulacyjny (internet Quarterly on Antitrust and Regulation)

Wynikająca z art. 45 u.k.k. sankcja kredytu darmowego (dalej: SKD) niesie za sobą duże ryzyko dla kredytodawców (tzw. ryzyko braku zgodności) za naruszenie kontraktowych obowiązków informacyjnych w umowach kredytu konsumenckiego. Jest obecnie niezwykle żywotnym i doniosłym na rynku konsumenckich usług kredytowych problemem tak dla praktyki rynkowej (kredytodawców), jak i dla wymiaru sprawiedliwości oraz organów ochrony konsumenta (szczególnie Rzecznika Finansowego i Prezesa UOKiK), z uwagi na masowe dochodzenie roszczeń z nią związanych. Celem niniejszego opracowania jest dokonanie analizy art. 45 u.k.k. pod kątem możliwej wykładni tego przepisu i udzielenia odpowiedzi na pytanie: czy naruszenie przez kredytodawcę wszystkich wskazanych w art. 45 …

Transposable Element-Derived Mir-28-5p And Mir-708-5p: Exploring Potential Roles In Lung Cancer, Sergiu Chira, Cornelia Braicu, Stefan Strilciuc, George A Calin, Ioana Berindan-Neagoe

Faculty, Staff and Student Publications

Background: Transposable elements are normally silenced by epigenetic mechanisms; however, during malignant transformation, epigenetic alterations enable transposons to produce functional molecules like miRNAs. Among these, LINE-2 (L2) elements can generate miRNAs capable of regulating key genes, including tumor suppressors. Two L2-derived miRNAs, miR-28 and miR-708, have been linked to lung cancer, yet the mechanisms underlying their dysregulation remain poorly understood. Our study reveals how genomic context contributes to aberrant gene expression through comprehensive bioinformatic analyses.

Methods: Using bioinformatics analysis, we evaluated the expression of miR-28 and miR-708 in lung adenocarcinoma (LUAD) and lung squamous cell carcinoma (LUSC) datasets from TCGA. …

Gauge Invariance And Repeated Time Isolated Solution Discontinuities, James Glimm, James Glimm, James Glimm

Department of Applied Mathematics & Statistics Faculty Publications

The main conclusion of this paper is (a) a gauge structure for the underlying physics, at or above a critical dimension, forces multiple time isolated solution discontinuities (blowups). The main conclusion (b) is that the solution is one Sobolev index more singular that the natural Hilbert space H. Proofs are given for Navier-Stokes fluids.

Trametinib Decreased Intracerebral Hemorrhages And Endothelial-To-Mesenchymal Transition In Kras, Ohnmar Myint, Bridger Freeman, Jae Yeong Jeong, Hyejin Park, Samantha M Wilfur, Shuning Huang, Jung-Eun Park, Jakob Körbelin, Jaroslaw Aronowski, Eun S Park, Peng R Chen, Eunhee Kim

Faculty, Staff and Student Publications

Background: Brain arteriovenous malformations (bAVMs) are a major risk factor for intracerebral hemorrhages in young patients. Recent clinical studies have reported that the majority of human bAVMs harbor somatic KRAS mutations. In our previous study, we confirmed the causal role of endothelial KRASG12V mutation in bAVM development in mice through hyperactivation of the MEK/ERK (extracellular signal-regulated kinase) pathway. However, the treatment efficacy of targeting MEK/ERK signaling in bAVMs, regarding clinical and biological outcomes, remains unclear.

Methods: In this study, we used the Food and Drug Administration-approved MEK inhibitor, trametinib, to treat mice with bAVMs induced by brain endothelial cell (EC)-specific …

Book Review: Disputed Decisions Of World War Ii: Decision Science And Game Theory Perspectives, James Allen Knechtmann

Parameters Bookshelf – Online Book Reviews

Author: Mark Thompson

Reviewed by: James Allen Knechtmann, supervisory archivist, chief, Ridgway Library Branch, Army Heritage and Education Center, US Army War College

In this innovative analysis of World War II, Thompson applies decision science and game theory to reexamine some of the conflict’s most controversial strategic choices. By modeling the logic behind pivotal decisions, he challenges conventional narratives and reveals the complexity of wartime leadership. This book offers a fresh lens for historians, strategists, and analysts seeking deeper insight into the calculus of war.

2025-12-18 University Graduate Committee Emergency Meeting Minutes, Morehead State University. Faculty Senate., University Graduate Committee.

Faculty Senate Records

Emergency meeting minutes from the University Graduate Committee from December 18, 2024.

Ai Context Automaton – Extended Architecture For Compliance-Aware Local Memory And Environmental Optimisation, David R P Chiesa

Defensive Publications Series

AI Context Automaton introduces a dual-AI architecture that transforms stateless AI interactions into a stateful, compliance-aware, and environmentally optimised workflow. The system combines a local AI for memory management and compliance enforcement with a cloud-based AI for reasoning, leveraging a markdown-based knowledge base for persistent storage. By offloading memory operations and compliance checks to local devices, the architecture minimises repeated cloud compute cycles, reducing energy consumption, carbon footprint, and operational costs while ensuring adherence to organisational governance standards.

Lithium–Sulfur Batteries: 3d Printed Tools And Assembly Techniques For Repeatable Lab-Scale Coin Cell Manufacturing, Daryl Miranda, Tosif Aliyev, Lamija Kovacevic, Sivapriya Voleti, Jaydie Lee, Kathleen Meehan, Monica C. So, Philip T. Dirlam

Faculty Research, Scholarly, and Creative Activity

The coin cell form factor has become a standard in energy storage research owing to its relatively low cost, low quantity of requisite electroactive material, fast experimental turnover, and capability to generate publishable quality data. Coin cell assembly at the lab-scale requires precise manual alignment of the many internal components of a cell to yield a properly functioning device. Truly repeatable device assembly presents a significant challenge to the acquisition of reliable data. In this report, we present a three-dimensional (3D) printable design for a coin cell alignment device and describe techniques for a generalized workflow to achieve reproducible coin …

The Role Of Dust Inputs And Sediment Phosphorus Diffusion Into Utah Lake, Utah, United States Of America, Kristen E. Smith

Theses and Dissertations

Human activities have led to excessive nutrient enrichment which is greater than lake systems can naturally assimilate. This process is known as eutrophication and it is driving significant algae growth resulting in the more common release of harmful toxins. Utah Lake, located in Utah County, UT is one such water body that even after major reductions in anthropogenic phosphorus influent, continues to experience frequent, harmful algal blooms. The extent to which natural processes, like atmospheric dust deposition and sediment recycling, contribute to the lake's phosphorus budget is still poorly understood.

To address this gap of knowledge, this study quantified phosphorus …

Attitudes And Perception Of Lis Students Towards Artificial Intelligence(Ai), Shahzadi Humbhi, Shabbir Tareen, Alia Humbhi

Library Philosophy and Practice (e-journal)

Artificial Intelligence refers to computer systems that can think and behave like humans. It is becoming essential in the education system as it has the potential to transform the way of teaching and learning in an academic environment. Therefore, the current study aims to investigate LIS students' attitudes and perceptions of AI, as well as how these technologies benefit their academic performance. The study also identified barriers that LIS students confront when adopting AI tools. For this purpose, a survey questionnaire was designed to assess students' knowledge and attitudes concerning AI, as well as its applications to improve academic performance. …

Evaluating Traffic Safety And Geometric Characteristics Using Machine Learning Ensemble Techniques: A Case Study Of Egyptian Rural Multi-Lane Divided Roads, Sania R. Elagamy, Ahmed N. Awaad, Usama E. Shahdah, Sherif M. El-Badawy, Marwa E. Elbany, Eman K. Ali

Mansoura Engineering Journal

Crash prediction models are essential for evaluating traffic safety by analyzing crash occurrence, frequency, or severity. Recently, machine learning techniques have gained prominence in statistical regression modeling and data analysis. This study assesses the effectiveness of machine learning in predicting crashes on Egyptian rural multi-lane divided roads using limited regional data. Supervised machine learning ensemble techniques were applied to predict crash-prone segments (classification) and estimate the total number of crashes per segment (regression). A comparative analysis aims to identify the most suitable method. The Synthetic Minority Oversampling Technique (SMOTE) addressed data imbalance, while K-means Clustering (KC) enhanced regression model accuracy, …

Framework For Process-Aware Cyber-Physical Security Monitoring, Detection, Triage, And Response, Moath Sakaji

Defensive Publications Series

This disclosure describes techniques of process-aware cyber-physical security in an operational technology (OT) environment. Time-series process data is ingested from a secure replica of a process historian and IT security data. A cyber-physical context engine (CPCE) includes a library of machine learning models each trained for a specific operational state. The CPCE analyzes the process data to detect physical anomalies. Physical anomalies are correlated with IT security data to identify cyber-physical attack patterns. An incident response module enforces a safety-gated, collaborative workflow between security analysts and plant operators, prioritizing physical process stability. A generative AI-assisted workflow enables human analysts to …

Pooled Randomised Quartet Trials Assessing Effectiveness Of A Single Pill For Hypertension, Simone Marschner, Mark D Huffman, Desi Quintans, Jody Ciolino, Abigail Baldridge, Danielle Lazar, Emily R Atkins, Graham S Hillis, Mark R Nelson, Markus Schlaich, Anthony Rodgers, Clara K Chow

2020-Current year OA Pubs

BACKGROUND: Hypertension is a major cause of premature death worldwide, controlled by only one in five adults. Two trials (Australia and USA) found a single quadpill containing a quarter dosage of four classes of medication effective in reducing blood pressure (BP) among participants with hypertension. By pooling these trials, we can estimate the overall benefit of the quadpill and its heterogeneity across subgroups and two important barriers for BP control: clinician medication inertia and participant medication adherence.

METHODS: In a prespecified pooled individual participant data analysis of two QUARTET randomised, multicentre, double-blinded trials in people with hypertension using ≤1medication, quadpill …

Applied Methods For Matching Implementation Strategies To Determinants: A Scoping Review Of Scientific And Grey Literature, And Qualitative Exploration Of Practice Experiences, Christiaan Vis, Leti Van Bodegom-Vos, Bethany Hipple-Walters, Byron J Powell, Erwin Ista, Femke Van Nassau

2020-Current year OA Pubs

BACKGROUND: Tailored implementation addresses the inherent dynamic complexity and heterogeneous nature of implementation practice. In general, tailored implementation involves setting implementation objectives, identifying determinants, matching strategies to those determinants, and developing an evaluation plan. How matching a specific implementation strategy to a determinant is done remains largely unknown. This study aimed to provide an overview of methods for matching strategies that have been applied in research and practice.

METHODS: A scoping review of scientific and grey literature was conducted. A Rapid Assessment Procedure approach guided the design and analysis. Five online scientific bibliographic databases and various Dutch websites were searched …

The Singlet Scalar State In A Chiral Ensemble In $Su(2)$ With Two Fundamental Flavours, Laurence Bowes, Vincent Drach, Patrick Fritzsch, Sofie Martins, Antonio Rago, Fernando Romero-Lopez

School of Engineering, Computing and Mathematics

Composite Higgs models are a class of Beyond the Standard Model (BSM) models proposed to address the hierarchy and naturalness problems associated with the Standard Model (SM) Higgs. A new QCD-like strongly interacting sector based on SU(2) with two fundamental flavours can be used to build a composite Higgs model which is not yet ruled out by experiment. The role of the singlet scalar resonance will affect Higgs phenomenology at the LHC. In this project our goal is to understand the properties of the singlet scalar state in the new strongly interacting sector in isolation as a first step to …

Bystander Interventions And Their Impact On Road Injury Outcomes: A Scoping Review, Nicholas Aveyard, George Stephen Russam, Jake Gluyas-Harris, Tim Nutbeam

Peninsula Medical School

Background: Road injury remains a leading global cause of death and disability, particularly in low- and middle-income countries (LMICs) where emergency medical services (EMS) are often limited or incur prolonged response times. In many trauma cases, bystanders are the first to respond and may play a critical role in patient outcomes. While the importance of bystander cardiopulmonary resuscitation (CPR) in cardiac arrest is well-established, the evidence regarding bystander interventions in trauma care, particularly following road injury, is less well defined. This scoping review systematically examined the prevalence, nature, and impact of bystander interventions following trauma, with particular emphasis on road …

Ai-Based Digital Concierge For Complex Financial Queries, Ankit Aggarwal, Jose Estevez, Chin Powit Rungsangthiwakorn, Samreen Dhillon

Defensive Publications Series

Maximizing savings, e.g., by choosing an appropriate form of payment, voucher/offer, merchant, etc. is difficult due to the need to analyze a large amount of information to determine the best combination when making a purchase. This disclosure describes a digital payment concierge that can answer complex financial queries. The concierge is implemented using an agent-based framework. To understand user intent, an orchestration agent is implemented using a suitable artificial intelligence model and a custom prompt. The orchestration agent routes tasks to specialized subagents, such as a savings maximizer which finds the best price by stacking offers and considering the user's …

Mechanistic And Functional Characterization Of Abtb2 As A Novel Target For Pancreatic Cancer Therapy, Nan Lyu, Olamide T Olaoba, Qiongling Wang, Harinarayanan Janakiraman, Xinjian Liu, Ernest Ramsay Camp, Kun Cheng, Eric T Kimchi, Yi Miao, Kevin F Staveley-O'Carroll, Guangfu Li

Faculty, Staff and Students Publications

BTB/POZ domain-containing proteins are increasingly recognized for their context-dependent roles in cancer, acting as either tumor suppressors or oncogenic drivers depending on the cancer type. Among them, the function of ankyrin repeat and BTB domain-containing protein 2 (ABTB2) in pancreatic ductal adenocarcinoma (PDAC), a highly lethal malignancy, has remained unexplored. In this study, we employed comprehensive functional genomics approaches—siRNA/shRNA knockdown, CRISPR-Cas9 knockout, plasmid-based overexpression, and a Cre-LoxP transgenic mouse model—to systemically modulate ABTB2 expression in human and murine PDAC cell lines, as well as in the KPC mouse model of PDAC. Our gain- and loss-of-function studies revealed that ABTB2 plays …

A Matrix-Independent Method For Direct Nanomolar Dissolved Aluminium Analysis In Seawater Using Programmable Flow Injection (Pfi), Maxime M. Grand, Mariko Hatta

Faculty Research, Scholarly, and Creative Activity

Existing shipboard methods for dissolved Aluminium (Al) analysis in seawater require complex instrumentation, highly trained analysts, and calibration with ultra-clean seawater standards to achieve sub-nanomolar sensitivity at sea. To address these challenges, we developed a compact, user-friendly, and low-maintenance method for the determination of dissolved Al in seawater based on programmable Flow Injection (pFI) and the lumogallion fluorescence assay. We optimized reaction conditions and the pFI mixing protocol to minimize matrix effects, enabling accurate quantification of seawater samples using standards prepared in ultrapure water. The resulting Brij-enhanced fluorometric method yields a detection limit of 0.5 nM and '3 % precision …

Life-Threatening Bradycardia In Anti-Nmda-Receptor Encephalitis And A Novel Use For Permanent Pacing, Sarah Tucker, Abhijit Das, Andres Jimenez, Areeba Basit, Yike Jiang, Emily A Smitherman, Heather Van Mater, Taylor Howard, Alexander J Sandweiss, Kristen S Fisher

Faculty, Staff and Students Publications

Background: Pediatric anti-NMDA receptor encephalitis (pNMDARE) is an autoantibody-mediated disorder that can cause severe autonomic dysfunction, including symptomatic bradycardia and asystole. Dysautonomia can last for years, making it very challenging to manage.

Objective: To describe outcomes of 5 pNMDARE patients with life-threatening bradycardic and/or asystolic events who were managed with permanent or semi-permanent pacemaker implantation.

Methods: We performed a retrospective chart review of 5 patients from multiple institutions. We included patients with a diagnosis of pNMDARE (confirmed by positive cerebrospinal fluid and/or serum anti-NMDAR antibodies) who had a permanent or semi-permanent pacemaker placed due to symptomatic bradycardia, sinus pauses, and/or …

Acceptance And Commitment Therapy: A Treatment Option For Substance Use Disorders, Miriam N. Mukasa, Ashley Yaugher, Ty Aller

All Current Publications

There are many evidence-based treatments for individuals experiencing substance use disorders (SUDs) that support both individuals and families. Psychological treatments are effective for a wide range of SUDs, making them a key approach for helping people with differing needs. This fact sheet provides information on treatments and provides more detail about acceptance and commitment therapy as a SUD treatment support.

Mineralocorticoid Receptor Antagonists For Acute Myocardial Infarction: A Systematic Review And Meta-Analysis Of Randomised Controlled Trials, Song Peng Ang, Jia Ee Chia, Bruno Bezerra Lima, Jose Iglesias, Eunseuk Lee, Chayakrit Krittanawong, Mahboob Alam, Debabrata Mukherjee

Faculty, Staff and Students Publications

Background: The role of mineralocorticoid receptor antagonists (MRAs) in acute myocardial infarction (MI) remains controversial, with conflicting evidence from landmark trials. We aimed to assess the impact of MRAs on mortality and cardiovascular outcomes post-acute MI.

Methods: We systematically searched PubMed, Embase and Cochrane CENTRAL databases up to February 2025 for randomised controlled trials comparing MRAs with placebo or standard care in adults experiencing acute MI. Primary outcome was all-cause mortality; secondary outcomes included cardiovascular mortality, heart failure, recurrent MI and ventricular arrhythmia. Data were pooled using random-effects models, with heterogeneity explored via subgroup analyses and meta-regression.

Results: 15 trials …

Presence Of Eosinophils May Represent An Earlier Stage In Achalasia Pathogenesis, Andrea Costantini, Chandra Prakash Gyawali, Francesca Forattini, Valentina Angerilli, Matteo Ghisa, Luca Provenzano, Giovanni Capovilla, Loredana Nicoletti, Michele Valmasoni, Matteo Fassan, Edoardo Vincenzo Savarino, Renato Salvador

2020-Current year OA Pubs

BACKGROUND: Intraepithelial eosinophils have been described in patients with esophageal motor disorders. Conversely, motor disorders and even achalasia have been reported in patients with eosinophilic esophagitis (EoE).

OBJECTIVES: This prospective study aimed to further investigate the association between eosinophilia and achalasia.

DESIGN: This is a prospective study.

METHODS: A series of 30 consecutive treatment-naïve achalasia patients (mean age: 45.5 years, 53% female) undergoing laparoscopic myotomy were prospectively enrolled. Preoperative demographic and clinical data, radiological findings, and high-resolution manometry (HRM) features were collected. Patients underwent upper endoscopy with biopsy sampling before surgery, and two samples of distal esophageal muscle were obtained …

Limited Agreement On Acl Tear Location Between Arthroscopy And Mri: A Prospective Evaluation, Richard Silverman, Derrick M Knapik, Matthew V Smith, Jonathan C Baker, Kelby Napier, Matthew J Matava, Robert H Brophy

2020-Current year OA Pubs

BACKGROUND: Renewed interest in anterior cruciate ligament (ACL) preservation has led to increased focus on tear location within the knee joint in treatment decisions, with primary ACL repair reserved for proximal tears. Retrospective studies have reported varying tear locations in adults when assessed on magnetic resonance imaging (MRI), with few studies comparing tear location on MRI versus intraoperative findings.

PURPOSE: To prospectively determine the distribution of ACL tear location assessed on MRI versus intraoperative evaluation to test the hypothesis that < 15% of ACL tears are proximal type avulsions.

STUDY DESIGN: Cohort study (Diagnosis); Level of evidence, 2.

METHODS: A total of 174 patients with clinically confirmed full-thickness ACL …

Genomic Characterization Of Colorectal Tumors: Insights Into Significantly Mutated Genes, Pathways, And Survival Outcomes, Tabitha A Harrison, Yin Cao, Et Al.

2020-Current year OA Pubs

BACKGROUND: Identifying significantly mutated genes in tumors aids in understanding disease etiology and survival and may aid in the discovery of new drug targets. We aimed to detect and characterize mutated genes from a large, well-characterized group of colorectal cancers.

METHODS: In tumor and paired normal samples from 6,111 colorectal patients, we sequenced 199 genes identified from whole exome sequencing of over 1,100 tumors. Analyses focused on non-silent mutations. We classified significantly mutated genes after stratification by hypermutation status, and estimated associations of mutated genes/pathways with disease-specific (DS)-survival using Cox regression, adjusting for age, sex, mutation burden, hypermutation status, and …

Hybrid Machine And Deep Learning Framework For Secure Fog-Based Vanets, Hadeer Kamal, Amira Y. Haikal, Mahmoud M. Saafan

Mansoura Engineering Journal

As a conventional implementation of intelligent transportation systems (ITS), a Vehicular Ad-hoc Network (VANET) facilitates smart communication between vehicle nodes and network infrastructures. Nevertheless, the distributed and dynamic characteristics of VANETs make them vulnerable to numerous cyberattacks like DOS and spoofing. Rapid detection of these threats is crucial. It is essential to respond promptly to mitigate threats before they impact vehicle coordination or infrastructure functionality. In this context, fog computing presents an effective solution. Transferring computational tasks from centralized cloud servers to fog nodes allows for quicker detection within the VANET environment. This research utilizes computational resources for swift and …

Integration Of Algae In Buildings: Challenges And Opportunities, Marwa Said Saad, Mostafa Refaat, Ashraf Nessim

Mansoura Engineering Journal

Buildings produce 40% of energy-associated CO2 emissions and 35% of worldwide energy use which makes it one of the main factors of global warming. The use of bioactive materials on building façades is a creative way to address the aforementioned problems. The biotechnical potential of microalgae architecture to achieve net-zero energy architecture while simultaneously advancing ecological sustainability and occupant well-being has drawn attention. This paper aims to analyzing and investigating techniques of integration of algae in architecture showing the challenges and opportunities of this implementation. Analytical and Comparative analytical method were used in this paper, Initially, a thorough literature review …

Picturing Disparities: Unveiling Gendered Racism In Athletic Leadership Through Photo Elicitation, Eddie Comeaux, Ajhanai C.I. Keaton, Briana A. Savage, Dresden June Frazier, Sara Grummert

Journal of Issues in Intercollegiate Athletics

This study explored National Collegiate Athletic Association (NCAA) Division I athletic administrators’ views regarding the professional accomplishments of women athletic directors by race/ethnicity. More than 2,000 full-time athletic administrators (e.g., athletic directors, academic advisors/counselors for athletes, and coaches) responded to a photograph of and vignette about either a Black or white woman athletic director. The study found that although some athletic administrators were supportive of women athletic directors regardless of race, some showed signs of race evasiveness and stark differences in their perceptions of deservingness consistent with racial bias. These findings have implications for campus leaders and other higher education …