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Can Whistleblowing Improve Organizational Effectiveness? Evidence From Financial Reporting Misconduct, Hong Kim Duong, Sadok El Ghoul, Omrane Guedhami, Emmanuel Sequeira, Zuobao Wei

Faculty Research, Scholarly, and Creative Activity

Background: While whistleblowing (WB) has attracted growing research interest in recent years, several critical WB-related issues remain underexplored. Purpose: This study examines the impact of external WB allegations on a firm’s organizational capital (OC). Such allegations often indicate management’s failure to address employee concerns internally, spotlighting potential deficiencies in internal reporting systems, employee communication, training, and trust in organizational fairness. To mitigate reputational damage, restore employee trust, and prevent future incidents, we posit that WB firms respond by increasing OC investment. Research Design: We employ a difference-in-differences approach, comparing OC changes in WB-targeted firms with those in a propensity score-matched …

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Evaluating Seasonal Vs. Spatial Extrapolation For Cetacean Distribution Models In The California Current, Elizabeth A. Becker, Karin A. Forney, Bruce J. Thayre, Katherine Whitaker, Ryan Hoopes, Joshua M. Jones, John A. Hildebrand, Jeff Moore

Faculty Research, Scholarly, and Creative Activity

Species distribution models (SDMs) have been developed for multiple cetacean species within the California Current Ecosystem (CCE) from shipboard survey data collected by the Southwest Fisheries Science Center (SWFSC) in summer and fall, thus limiting the ability to inform management decisions in cool seasons when abundance and distribution patterns are substantially different. Winter and spring SDMs have been developed for a few species using California Cooperative Oceanic Fisheries Investigations (CalCOFI) shipboard survey data, but model predictions are limited to the waters off southern and central California. In this study, winter and spring density estimates for the entire CCE study area …

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Potential Impact Of Increased Global Warming On The Hydroclimatology Of Central Africa During The Twenty-First Century, Abdon K. Dessacka, Thierry C. Fotso-Nguemo, Moustapha Tall, Zéphirin D. Yepdo, Steven Chouto, Bienvenue D. Dikwa, Crépin K. Komelo, Rodric M. Nonki, Ismaila Diallo, Arona Diedhiou, David Monkam, Hamid Sana

Faculty Research, Scholarly, and Creative Activity

Africa is highly susceptible to the adverse effects of climate change, particularly changes in hydroclimatic conditions. Assessing the impacts that could be reduced by limiting global warming is therefore crucial to strengthening adaptation to climate change, especially in Central Africa, known for its rich biodiversity along with the diversity of its ecosystems. In that perspective, the purpose of the present study is to assess the projected impact of increased global warming on the hydroclimatology of Central Africa, based on an ensemble-mean of high-resolution regional climate model (RCM) simulations from the Coordinated Output for Regional Evaluations integrated into the Coordinated Regional …

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Grand Challenges For Human Factors And Ergonomics, Waldemar Karwowski, Gavriel Salvendy, Mica Endsley, William Rouse, Paul Salmon, Kay Stanney, Andrew Thatcher, Tony Andre, Jessie Yang, Hasan Ayaz, Ahmet Cakir, Vince Duffy, Colin Drury, Qin Gao, Yinni Guo, Peter Hancock, William S. Marras, Patrick Rau

Faculty Research, Scholarly, and Creative Activity

Contemporary society faces a growing set of complex global issues representing significant human health, well-being, and sustainability threats. Human Factors and Ergonomics (HFE) has a critical role to play in responding to these issues; however, there remain a set of grand challenges that require resolution. This paper presents and discusses six grand challenges for HFE and related key research thrust areas for each of the challenges. The grand challenges are (1) Evolution in Societal Thinking; (2) Future of Human Work in Industry 5.0; (3) Climate Change and Sustainability; (4) Future of Education and Training; (5) Future of Personalized Health, and …

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Applying Machine Learning And Optimization Algorithms To Perform Feature Selection, Shizhao Yu

Theses and Dissertations (Comprehensive)

The objective of feature selection in the realms of machine learning and data mining is integral, serving as an efficient mechanism to eradicate redundant or irrelevant features, and subsequently augmenting the performance of predictive models. In the contemporary landscape of big data, with the escalating dimensionality of datasets, the efficacy of traditional feature selection methodologies is compromised, due to their computational complexity and ineptitude in addressing the curse of dimensionality. This thesis posits a pioneering feature selection framework that amalgamates machine learning with advanced optimization algorithms. The methodology employs a Support Vector Machine (SVM), in conjunction with a cutting-edge metaheuristic …

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Case Report: Disseminated Herpes Simplex Virus Complicated By Hemophagocytic Lymphohistiocytosis In A Neonate, Nicholas Tadros, Nihal Godiwala

School of Medicine Faculty Publications

Neonatal herpes simplex virus (HSV) infection carries a high mortality rate due to its potential to cause disseminated disease involving multiple organ systems, which can rapidly progress to shock and death if not promptly treated. In rare cases, neonates may mount an uncontrolled inflammatory response leading to hemophagocytic lymphohistiocytosis (HLH), a severe hyperinflammatory syndrome. We present a case of neonatal HSV infection complicated by HLH, highlighting the challenges of managing both conditions concurrently. Our therapeutic approach demonstrated a reduction in systemic inflammation and viral load; however, despite these efforts, the patient developed multiorgan failure and ultimately died from the initial …

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A Non-Toxic Analgesic Elicits Cell-Specific Genomic And Epigenomic Modulation By Targeting The Pag Brain Region, Hernan A. Bazan, Brian L. Giles, Surjyadipta Bhattacharjee, Scott Edwards, Nicolas G. Bazan

School of Medicine Faculty Publications

Acetaminophen (ApAP) is widely used for pain management, but overuse or overdose leads to hepatotoxicity, making it the leading cause of acute liver failure globally. There is an urgent need for safer pain medications, as other non-opioid analgesics like non-steroidal anti-inflammatory drugs (NSAIDs) are nephrotoxic. We have identified SRP-001 as a safer, non-hepatotoxic, novel analgesic that overcomes ApAP's limitations by avoiding NAPQI formation and preserving hepatic tight junctions. Using coupled RNA and ATAC sequencing, from the periaqueductal gray (PAG) midbrain region, we compared the genetic and epigenetic signatures of SRP-001 and ApAP treatments following complete Freund's adjuvant (CFA)-induced inflammatory pain …

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001-S4-Lna-77.01, Morehead State University. History Department.

Defending Savannah: History and Archaeology of the Gibson's Point Battery

No abstract provided.

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Multidisciplinary Emergent Control Of Traumatic Neovaginal Bleeding After Foreign-Body Insertion In The Early Postoperative Period After Gender-Affirming Vaginoplasty., Tanisha S Kashikar, Christopher D Mcclung, Michal A Radomski, Anand K Joshi, David C Evans

Trauma and Acute Care Articles

As gender-affirming surgery becomes more widespread, it is important that healthcare providers recognize complications related to gender-affirming surgery. Although rates of postoperative bleeding after gender-affirming vaginoplasty are relatively low, it is imperative that this potentially life-threatening complication is recognized and managed quickly. This case highlights the importance of a multidisciplinary approach to the management of neovaginal bleeding that was unable to be controlled intraoperatively by suture ligation.

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Environmentally Persistent Free Radicals Lead To Selective Inhibition Of Cyp1 Monooxygenase Activities, And Increased Production Of Reactive Oxygen Species By Reaction Uncoupling, John Patrick Connick, Amari A. Stepter, George F. Cawley, Marilyn K. Eyer, Wayne L. Backes

School of Medicine Faculty Publications

This study focuses on the effect of Environmentally Persistent Free Radicals (EPFRs) on the P450 enzymes of the CYP1 family. EPFRs are a component of particulate pollutants, that are stable in the environment, but can generate free radicals, leading to oxidative stress and subsequent toxicity of the respiratory, cardiovascular, and immune systems once they enter an organism. The results show differences in the ability of EPFRs to inhibit CYP1-dependent substrate metabolism, with CYP1B1 being inhibited to the greatest extent. There also were differences in the ability of EPFRs to disrupt the POR•CYP1 complex, with CYP1B1 being the only form where …

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Chronic Administration Of A Cannabis-Derived Mixture At An Antihyperalgesic Dose Does Not Significantly Enhance Hepatotoxicity Or The Development Of Metabolic Dysfunction-Associated Steatohepatitis In Male Mice, Kim B. Pedersen, Tomislav Jelesijevic, Tamara M. Morris, Sarah M. Melton, Ashley S. Henderson, John F. Glenn, Gregory J. Davenport, Martin J.J. Ronis, Peter J. Winsauer

School of Medicine Faculty Publications

Cannabis and cannabinoid mixtures have been linked to a variety of health benefits including pain mitigation, suppression of nausea produced by chemotherapeutic agents, anti-inflammatory effects, and effects on energy homeostasis, glucose, and lipid metabolism. The latter properties have led to the suggestion that these products could have therapeutic effects on the development of metabolic dysfunction-associated steatohepatitis (MASH) - a severe type of liver pathology in obese and diabetic patients. However, varying agonist and antagonistic properties of different cannabinoids on the endogenous cannabinoid system make prediction regarding hepatic effects and diet interactions difficult. The current study was designed to examine hepatic …

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Multi-Modal Neo-Adjuvant Anti-Obesity Medications May Be More Effective Than Medically Supervised Weight Loss Or Glp-1 Therapy Alone In Preparing Bmi ≥ 70 Patients For Metabolic Surgery, Michael Kachmar, Florina Corpodean, Iryna Popiv, Kyle B. Lapenna, Denise M. Danos, Michael W. Cook, Brian A. Saunders, Jean J. Domercant, Vance L. Albaugh, Philip R. Schauer

School of Medicine Faculty Publications

Background/objectives: Optimizing patients with a body mass index (BMI) ≥ 70 kg/m² for metabolic surgery (MS) is challenging. However, pre-operative weight loss may be important for improving the safety of MS for these high-risk patients. Multi-modal anti-obesity medications (mmAOM) may enhance preoperative weight loss compared to non-pharmacologic medically supervised weight loss (NP-MSWL) or glucagon-like peptide-1 receptor agonist monotherapy (Mono-GLP-1) alone. Subjects/methods: This retrospective study analyzed 113 patients with BMI ≥ 70 kg/m² at a single metabolic disease treatment institute. Interventions/methods: Patients were categorized into NP-MSWL (n = 13), Mono-GLP-1 (n = 54), and mmAOM (n = 46) groups. The primary …

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Endogenous Self-Peptides Guard Immune Privilege Of The Central Nervous System, Min Woo Kim, Wenqing Gao, Cheryl F Lichti, Xingxing Gu, Taitea Dykstra, Jay Cao, Igor Smirnov, Pavle Boskovic, Denis Kleverov, Andrea F M Salvador, Antoine Drieu, Kyungdeok Kim, Susan Blackburn, Clair Crewe, Maxim N Artyomov, Emil R Unanue, Jonathan Kipnis

2020-Current year OA Pubs

Despite the presence of strategically positioned anatomical barriers designed to protect the central nervous system (CNS), it is not entirely isolated from the immune system

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Full-Text Articles in Entire DC Network

Can Whistleblowing Improve Organizational Effectiveness? Evidence From Financial Reporting Misconduct, Hong Kim Duong, Sadok El Ghoul, Omrane Guedhami, Emmanuel Sequeira, Zuobao Wei

Faculty Research, Scholarly, and Creative Activity

Evaluating Seasonal Vs. Spatial Extrapolation For Cetacean Distribution Models In The California Current, Elizabeth A. Becker, Karin A. Forney, Bruce J. Thayre, Katherine Whitaker, Ryan Hoopes, Joshua M. Jones, John A. Hildebrand, Jeff Moore

Faculty Research, Scholarly, and Creative Activity

Faculty Research, Scholarly, and Creative Activity

Faculty Research, Scholarly, and Creative Activity

Applying Machine Learning And Optimization Algorithms To Perform Feature Selection, Shizhao Yu

Theses and Dissertations (Comprehensive)

Case Report: Disseminated Herpes Simplex Virus Complicated By Hemophagocytic Lymphohistiocytosis In A Neonate, Nicholas Tadros, Nihal Godiwala

School of Medicine Faculty Publications

A Non-Toxic Analgesic Elicits Cell-Specific Genomic And Epigenomic Modulation By Targeting The Pag Brain Region, Hernan A. Bazan, Brian L. Giles, Surjyadipta Bhattacharjee, Scott Edwards, Nicolas G. Bazan

School of Medicine Faculty Publications

001-S4-Lna-77.01, Morehead State University. History Department.

Defending Savannah: History and Archaeology of the Gibson's Point Battery

Multidisciplinary Emergent Control Of Traumatic Neovaginal Bleeding After Foreign-Body Insertion In The Early Postoperative Period After Gender-Affirming Vaginoplasty., Tanisha S Kashikar, Christopher D Mcclung, Michal A Radomski, Anand K Joshi, David C Evans

Trauma and Acute Care Articles

Environmentally Persistent Free Radicals Lead To Selective Inhibition Of Cyp1 Monooxygenase Activities, And Increased Production Of Reactive Oxygen Species By Reaction Uncoupling, John Patrick Connick, Amari A. Stepter, George F. Cawley, Marilyn K. Eyer, Wayne L. Backes

School of Medicine Faculty Publications

School of Medicine Faculty Publications

School of Medicine Faculty Publications

2020-Current year OA Pubs