Open Access. Powered by Scholars. Published by Universities.®

Digital Commons Network

Open Access. Powered by Scholars. Published by Universities.®

2025

Discipline
Institution
Keyword
Publication
Publication Type
File Type

Articles 156241 - 156270 of 156289

Full-Text Articles in Entire DC Network

Tackling Australia’S Male Teacher Shortage: Insights From Initial Teacher Education (Ite) Completion Data, Loan Dao, Jeanne M. Allen, Darren Pullen, Scott Cowie Jan 2025

Tackling Australia’S Male Teacher Shortage: Insights From Initial Teacher Education (Ite) Completion Data, Loan Dao, Jeanne M. Allen, Darren Pullen, Scott Cowie

Australian Journal of Teacher Education

The under-representation of males in the Australian teaching profession has been an issue of concern for some time. With predictions that the situation will worsen due to an aging male teacher population and the enduring perception that teaching is females’ work, this paper explores trends in male initial teacher education (ITE) degree completion in a sample of Australian ITE programs from 2001 to 2021 to gain insights into which types of teaching degrees and delivery modes of study are most likely to attract potential pre-service male teachers. Open access and non-identifiable male ITE completion data were obtained from the Australian …


What Mentorship? Pre-Service And In-Service Teachers’ Experiences Of A Teaching Practice Mentorship Programme, Puleng Constance Letloenyane, Matseliso Mokhele-Makgalwa, David Maleho Letloenyane Jan 2025

What Mentorship? Pre-Service And In-Service Teachers’ Experiences Of A Teaching Practice Mentorship Programme, Puleng Constance Letloenyane, Matseliso Mokhele-Makgalwa, David Maleho Letloenyane

Australian Journal of Teacher Education

Mentoring during teaching practice plays a crucial role in teacher training as it exposes pre-service teachers to an authentic teaching and learning environment, under the guidance of qualified in-service teachers. Although mentoring has the potential to enhance the preparation of pre-service teachers and to improve the development of in-service teachers, the experiences are not always positive. The present study seeks to explore pre-service teachers’ and in-service teachers’ experiences of one university’s teaching practice mentorship programme. This single case study employed semi-structured interviews to collect data from one in-service and pre-service teacher in one suburban school. The collected data indicate that …


Chinese Secondary School Teachers' Perceptions Of Teacher Candidates' Teaching Ability And Performance, Liyuan Chen, Chia Ching Tu Jan 2025

Chinese Secondary School Teachers' Perceptions Of Teacher Candidates' Teaching Ability And Performance, Liyuan Chen, Chia Ching Tu

Australian Journal of Teacher Education

: This study investigated secondary school teachers' beliefs about teacher educators’ teaching competencies and performance. Additionally, it compared the differences between the perceived importance of teaching competencies and the teaching performance level among teachers from different backgrounds. The Delphi method was first used to identify teaching competency items followed by a questionnaire survey to collect data from secondary school teachers in Hebei Province, China. Out of 700 questionnaires that were sent out, 539 valid questionnaires were returned. Secondary school teachers were highly aware of the importance of teaching competencies but did not possess these competencies. An importance-performance analysis (IPA) showed …


Unveiling Raciolinguistic Ideologies: Pre-Service Teachers’ Insights On Refugee Integration In Schools, Tuba Yilmaz, Rosanna Ellis Jan 2025

Unveiling Raciolinguistic Ideologies: Pre-Service Teachers’ Insights On Refugee Integration In Schools, Tuba Yilmaz, Rosanna Ellis

Australian Journal of Teacher Education

This study investigates pre-service teachers' ideologies about refugee students' belonging and integration in Türkiye and examines how these ideologies shape their anticipated pedagogical practices. Using the framework of raciolinguistic ideologies, the study highlights how linguistic and cultural hierarchies influence educational practices, often perpetuating systemic exclusion. Data were collected through in-depth interviews with 13 pre-service teachers from various educational programs, utilizing a qualitative, phenomenological design. The findings reveal a predominant reliance on deficit-based perspectives, with refugee students framed as linguistically deficient and culturally "othered." While participants expressed professional commitments to inclusivity, their approaches often emphasized assimilation into Turkish norms, reflecting cultural …


Australian Education Research Organisation And Teacher Education, Bruce Haynes Jan 2025

Australian Education Research Organisation And Teacher Education, Bruce Haynes

Australian Journal of Teacher Education

The Australian Education Research Organisation was created to initiate, collate and disseminate reliable evidence-based research to the Australian school system. It uses the latest cognitive psychology to advocate the use of explicit instruction and phonics to lift outcomes of Australian schooling. These practices are reflected in the new ‘core content’ for Initial Teacher Education programs that were identified by the Teacher Education Expert Panel to be mandated in national accreditation processes for tertiary providers delivering initial teacher education. Mandating these practices is problematic and marks a further shift towards authoritarian processes in Australia.


Teacher Training For Diversity: Analyzing Inclusive And Intercultural Education In Early Childhood Degrees Of Three Universities Located In Spain, France And Columbia, Odet Moliner, Aida Sanahuja, Daniel Niclot, Mariaangelica Yazzo Jan 2025

Teacher Training For Diversity: Analyzing Inclusive And Intercultural Education In Early Childhood Degrees Of Three Universities Located In Spain, France And Columbia, Odet Moliner, Aida Sanahuja, Daniel Niclot, Mariaangelica Yazzo

Australian Journal of Teacher Education

This study examines the integration of inclusive and intercultural education principles in the Bachelor’s Degree in Early Childhood Education at three Universities located in Spain, France and Colombia. An analysis of 116 course syllabi is conducted to identify the specific references to Universal Design for Learning, accessibility, inclusion, diversity and interculturality. A second content analysis was conducted to categorize the units of meaning into four categories and determine the predominant underlying approach to the use of the term 'inclusion' in each degree program. The results indicate that the concepts of accessibility and UDL are the least represented, followed by …


Harmonising The Rhythm Of Drumming With The Silence Of Meditation: An Autoethnography Of Initial Teacher Education (Ite), Elly S. Thomson Jan 2025

Harmonising The Rhythm Of Drumming With The Silence Of Meditation: An Autoethnography Of Initial Teacher Education (Ite), Elly S. Thomson

Australian Journal of Teacher Education

This article presents an autoethnographic examination of how my professional experiences inform and resist the cultural swing towards over standardisation in Initial Teacher Education (ITE) over the past twenty years. This has been articulated through five ‘turning point moments’ as reflective narratives from my professional journey. Drawing on epistemic reflexivity, this study highlights the risks of homogenising the teaching profession, arguing for an equity-focused approach that values diverse pathways and fosters inclusive classrooms. From this perspective, the paper critiques the current trends towards standardised, one-size-fits-all ITE entry requirements and conforming curriculum. The findings suggest the potential risks of such …


Enhancing Pre-Service Teachers’ Preparedness For Professional Experience Placement And Employment: Authentic School-University Partnership Opportunities, Stacey E. Jones, Deb Clarke Jan 2025

Enhancing Pre-Service Teachers’ Preparedness For Professional Experience Placement And Employment: Authentic School-University Partnership Opportunities, Stacey E. Jones, Deb Clarke

Australian Journal of Teacher Education

The transition from university learning to classroom application presents a challenge in initial teacher education. This transition results in ‘praxis shock’; a term coined to describe the confronting exposure to the gritty realities of the classroom. This case study investigated a school-university partnership that drew on authentic learning activities using a team-teaching model to address the praxis shock challenge. Data were gathered over five years from pre-service teacher subject experience surveys, journal reflections, and semi-structured interviews. The findings revealed that this authentic approach significantly enhanced pre-service teachers’ understanding of the Australian Professional Standards for teachers, their classroom readiness, confidence, and …


“My School Makes Even The Smallest Students …. Feel Included And Happy To Be There” Student Perspectives On Inclusion., Charles Ag Kemp, Umesh Sharma, Louise Mclean Jan 2025

“My School Makes Even The Smallest Students …. Feel Included And Happy To Be There” Student Perspectives On Inclusion., Charles Ag Kemp, Umesh Sharma, Louise Mclean

Australian Journal of Teacher Education

The objective of this study was to examine student perspectives on what inclusion means to them and what students believe to be critical school based inclusive practices. The study utilised a mixed method approach to collect data from a sample of 40 Year 9 and Year 10 students from a small school in rural Victoria.  Qualitative data were analysed using a three-stage process of thematic analysis.  Students emphasised that inclusion could be enhanced when relationships are prioritised, school environments are more participatory, when teachers know what students need to be successful, and, when teachers actively monitor and encourage the engagement …


Using Children's Picture Books To Teach Mathematical And Numeracy Concepts: An Exploration Of The Aesthetic Value Of Mathematics For Preservice Teachers’ Dispositions, Mellie Green, Lorraine Gaunt, Georgina M. Barton Jan 2025

Using Children's Picture Books To Teach Mathematical And Numeracy Concepts: An Exploration Of The Aesthetic Value Of Mathematics For Preservice Teachers’ Dispositions, Mellie Green, Lorraine Gaunt, Georgina M. Barton

Australian Journal of Teacher Education

Evidence suggests that preservice teachers tend to have negative dispositions towards the teaching of mathematics and/or numeracy. In response, this paper describes the work of three experienced teacher educators using high-quality children’s picture books to teach mathematical and/or numeracy concepts as well as foregrounding the aesthetic value of mathematics. The purpose of this type of reading is to support and improve preservice teacher dispositions towards mathematics and/or numeracy with children’s picture books. Using metalogue as methodology, the researchers discussed mathematical and/or numeracy concepts and explored the aesthetic value of mathematics within selected picture books. They used the Australian Curriculum’s General …


From Guesswork To Growth: Understanding How Preservice Teachers Interpret And Enact Appraisal Within A Teacher Performance Assessment, Allison Byth, Thembi Mason, Laurie Werrett Jan 2025

From Guesswork To Growth: Understanding How Preservice Teachers Interpret And Enact Appraisal Within A Teacher Performance Assessment, Allison Byth, Thembi Mason, Laurie Werrett

Australian Journal of Teacher Education

In Australia, the Graduate Teacher Performance Assessment (GTPA) is a capstone summative assessment evaluating preservice teachers ‘classroom readiness’ across five practices: planning, teaching, assessing, reflecting and appraising. In our work with preservice teachers, appraising the impact of teaching emerged as the most conceptually and practically challenging practice. To understand how preservice teachers interpreted and enacted appraisal, this exploratory case study analysed 15 GTPA submissions that met standards in the first four practices but not in appraisal. The findings highlight common issues, including conflating appraisal with general reflection, difficulty interpreting and applying data meaningfully, and presenting narrative accounts rather than evaluative …


Inspection Technologies For Construction And Maintenance Of Highway Infrastructure – Review And Analysis, Manideep Tummalapudi, Prem Raj Timilsena Jan 2025

Inspection Technologies For Construction And Maintenance Of Highway Infrastructure – Review And Analysis, Manideep Tummalapudi, Prem Raj Timilsena

Mineta Transportation Institute

The Federal Highway Administration (FHWA) and state Departments of Transportation (DOTs) seek to provide high quality infrastructure that meets or exceeds the desired quality standards crucial for ensuring safety and efficiency in our nation's transportation systems. Efficient inspection practices—which enable conformance with plans, specifications, and quality standards—are an essential part of this effort. In this digital age, state DOTs are relying on emerging technologies to improve inspection practices. However, there is limited knowledge available regarding various emerging technologies used for highway infrastructure construction and maintenance inspection. This study identifies various emerging technologies that are implemented at the state DOTs and …


Conceptual Critical Success Factors Model On Infrastructure Sustainability Rating System For California Construction Projects, Joseph J. Kim, Jose A. Arroyo-Turcios Jan 2025

Conceptual Critical Success Factors Model On Infrastructure Sustainability Rating System For California Construction Projects, Joseph J. Kim, Jose A. Arroyo-Turcios

Mineta Transportation Institute

This report addresses the sensitivity and reliability of the sustainability rating systems by comparing each category’s verified scores with its respective submitted scores to evaluate how points are awarded for infrastructure projects, examine which categories present the most challenges for verification, and identify the best category for verification in the sustainability rating system. The authors conducted three analyses using credit score data obtained from fourteen actual civil infrastructure projects certified under Envision. First, the Natural World category had the highest average score from the submitted and verified data. Pairwise comparisons using t-tests indicate that the mean value of one category …


Factors Affecting The Integration Of Dental Services Into Health And Social Care For People With Complex Needs, Afsha Musa, Joelle Booth, Hannah Wheat, Robert Witton, Martha Paisi Jan 2025

Factors Affecting The Integration Of Dental Services Into Health And Social Care For People With Complex Needs, Afsha Musa, Joelle Booth, Hannah Wheat, Robert Witton, Martha Paisi

Peninsula Dental School

Background: People with complex social and medical needs require a high level of support and face multiple barriers in accessing health and social care services. With limited access to dental care, their high oral health needs go largely unaddressed. Integration of oral healthcare into primary care, alongside improved cross-sector working, has been advocated to bring together services across the system to achieve oral health equity. Aim: To explore the factors affecting integration of dental services into health and social care for people with complex needs. Methods: A qualitative research study was undertaken across two sites in the southwest of England, …


Beyond The Drill: Understanding Empathy Among Undergraduate Dental Students, Muhammad Qasim Javed, Zaina Ahmad, Muhammad Muhammad, Kamran Ali, Arham Riaz, Rebecca Glanville Jan 2025

Beyond The Drill: Understanding Empathy Among Undergraduate Dental Students, Muhammad Qasim Javed, Zaina Ahmad, Muhammad Muhammad, Kamran Ali, Arham Riaz, Rebecca Glanville

Peninsula Dental School

Introduction: Compassionate care and empathy are fundamental components of health care which contribute to the social construction of physician–patient relationship to meet the expectations of the patients. The aim of this study was to evaluate clinical empathy among undergraduate dental students at a University in the Middle East. Materials and Methods: It was a cross-sectional study which used purposive sampling to recruit undergraduate dental students from five academic years. The Jefferson Scale of Physician Empathy-Health Profession Students was used, a reliable 20-item tool with a total score ranging from 20 to 140. Data collection was done online using Google Forms. …


Testing An Intervention To Develop Resilience In Student Nurses And Embed A Strategy In Undergraduate Curricula, Claire Chick Jan 2025

Testing An Intervention To Develop Resilience In Student Nurses And Embed A Strategy In Undergraduate Curricula, Claire Chick

School of Nursing and Midwifery Theses

BackgroundResilience is considered an umbrella term to encompass key factors including wellbeing, emotional intelligence, self-awareness and empathy. A growing body of literature concludes the necessity for resilience-enhancing interventions to be embedded in undergraduate curricula; it is not enough to simply assume that resilience and coping are an innate component of the student nurses’ journey.Aims and objectivesAims1. To identify if a novel action learning intervention is more effective in developing resilience in student nurses than current practice.2. To embed resilience education in undergraduate curricula to support students’ well-being.Objectives1. To compare the effectiveness of interventions with current practice2. To assess stakeholder engagement …


Machine Learning-Based Prediction Of Endometrial Cancer Prognosis, Sherif Shazly Jan 2025

Machine Learning-Based Prediction Of Endometrial Cancer Prognosis, Sherif Shazly

School of Nursing and Midwifery Theses

This thesis develops and uses machine learning tools to predict the prognosis of endometrial cancer. With endometrial cancer being the most common gynaecologic malignancy in low- and middle-income countries, accurate prognostic models are essential for improving patient outcomes. This research aims to develop and validate machine learning-based models to predict CSS (cancer-specific survival) and DFS (disease-free survival) at 3- and 5-year intervals, utilizing patient demographics, preoperative imaging, histopathological characteristics, and treatment data.The study employed multiple machine learning algorithms, including logistic regression, support vector machines, XGBoost, and random forest, to create three predictive models: a preoperative model, a management-based model, and …


Exploring The Role Of Irf4 In The Sensitivity Of Mantle Cell Lymphoma Cells To Bruton's Tyrosine Kinase Inhibitors, Artjoms Portnojs Jan 2025

Exploring The Role Of Irf4 In The Sensitivity Of Mantle Cell Lymphoma Cells To Bruton's Tyrosine Kinase Inhibitors, Artjoms Portnojs

Peninsula Medical School Theses

Introduction and aim: Mantle cell lymphoma (MCL) is an aggressive subtype of B-cell lymphoma. Therapy using Bruton’s tyrosine kinase (BTK) inhibitors has improved clinical outcomes but primary and secondary resistance to BTK inhibitor (BTKi) therapy affects more than half of MCL patients. Resistance most often arises through gene mutations in cells protected from BTKi effects within the local tissue microenvironment. This thesis develops previous work by the group identifying IRF4 as a central mediator of resistance to BTK inhibitors in MCL; the thesis aims to understand how resistance develops and to identify mechanisms to prevent or overcome BTKi resistance in …


Mishra L, Francis T, Nooji D, Aggarwal H, Mccoll E, Eachempati P. Current Concepts In Restoring Endodontically Treated Teeth., Lora Mishra, Prashanti Eachempati, Tony Francis, Devi Prasad Nooji, Himanshi Aggarwal, Ewen Mccoll Jan 2025

Mishra L, Francis T, Nooji D, Aggarwal H, Mccoll E, Eachempati P. Current Concepts In Restoring Endodontically Treated Teeth., Lora Mishra, Prashanti Eachempati, Tony Francis, Devi Prasad Nooji, Himanshi Aggarwal, Ewen Mccoll

Peninsula Dental School

Restoration of endodontically treated teeth (ETT) is crucial for long-term success. This article reviews current concepts in restoringETT, which focuses on structural integrity and functional performance. Key factors, including residual tooth structure, ferrule effect and pericervical dentine preservation, are discussed alongside advances in conservative access designs, biomimetic protocols and innovative materials,such as ultra-high molecular weight polyethylene fibres. Decision-making frameworks, including the Restorative Difficulty Evaluation System(RDES), are highlighted to support clinicians in achieving predictable outcomes, ensuring tooth survival and patient satisfaction.CPD/Clinical Relevance: The long-term success of endodontically treated teeth depends on selecting appropriate restorative strategiesthat ensure structural integrity, functional performance and …


Considering Behaviour In Genetic Sampling – A Case Study With Grey Seals, Kathryn Wiltshire Jan 2025

Considering Behaviour In Genetic Sampling – A Case Study With Grey Seals, Kathryn Wiltshire

School of Biological and Marine Sciences Theses

Genetic variations are increasingly linked to intra-specific behavioural variations. Advancing our knowledge of behavioural genetics could make screening populations for genetic polymorphisms associated with behavioural variations possible. Genetic-behaviour links have been increasingly discovered in terrestrial mammals, but there are few comparable studies in marine mammals. Developing efficient and cost-effective genetic sampling techniques is essential to allow more studies on behavioural genetics in lesser researched marine mammals. This study explores the potential of a sampling technique, still in its infancy in marine mammal studies, that has potential to cause minimal stress to the animals. Buccal swabs were tested in a group …


An Assessment Of The Dietary Bioavailability Of Tio2 And Inorganically Carbon-Based Nanomaterials In Rainbow Trout, Using The Ex Vivo Gut Sac Technique And A In Chemico Digestibility Assay, Craig Mchardy Jan 2025

An Assessment Of The Dietary Bioavailability Of Tio2 And Inorganically Carbon-Based Nanomaterials In Rainbow Trout, Using The Ex Vivo Gut Sac Technique And A In Chemico Digestibility Assay, Craig Mchardy

School of Biological and Marine Sciences Theses

Abstract. Craig McHardyAn assessment of the dietary bioavailability of TiO2 and inorganically carbon-based nanomaterials in rainbow trout, using the ex vivo gut sac technique and a in chemico digestibility assay.Carbon based engineered nanomaterials (ENMs) are an emerging contaminant within modern society, as such their environmental risk assessment is of high importance. Testing for their persistence, toxicity and bioaccumulation potential is important for regulatory bodies to fully understand the hazard posed. To date, data on the bioaccumulation potential of these ENMs is lacking, especially within fish. A tiered approach to bioaccumulation testing has been posed in which precursory tests such as …


Impact Of Dietary Functional Yeast Additives On Growth Performance And Health Of Selected Key Aquaculture Species, Sheu Odu-Onikosi Jan 2025

Impact Of Dietary Functional Yeast Additives On Growth Performance And Health Of Selected Key Aquaculture Species, Sheu Odu-Onikosi

School of Biological and Marine Sciences Theses

The aquaculture industry has witnessed remarkable growth in recent decades underscoring its crucial role in global food security. However, this rapid expansion brings challenges, including the need to meet growing fish demand while minimising environmental impacts and managing disease prevalence. Functional feed additives (FFAs) have emerged as sustainable solutions to enhance fish health and performance. Among these, yeast-derived additives have garnered significant attention for their nutritional benefits and proven ability to promote growth and strengthen immune responses in fish.This study evaluates the effects of dietary brewer's yeast-derived additives on fish using a range of in-depth analyses, such as growth performance, …


Unravelling The Ecological Trade-Offs In Behavioural And Physiological Sexual Traits, Alicia Eveson Jan 2025

Unravelling The Ecological Trade-Offs In Behavioural And Physiological Sexual Traits, Alicia Eveson

School of Biological and Marine Sciences Theses

Animals experience temporally and spatially heterogeneous environments throughout their lives. Therefore, individuals that are able to plastically adjust their behaviour to the current environment, are able to maximise their fitness. These behavioural adjustments are particularly important where there are trade-offs between investment in different life-history traits. Trade-offs between reproduction and survival have been widely documented, in addition to a body of evidence for trade-offs between mating related traits. How an individual adjusts their mating behaviour in response to their social and biotic environments are important aspects of selection. Changes in the social environment, including sex ratio or population density changes, …


Factors Controlling Protein Metabolism And Growth In The Common Limpet Patella Vulgata, Ignacio Alvarez-Cienfuegos Jan 2025

Factors Controlling Protein Metabolism And Growth In The Common Limpet Patella Vulgata, Ignacio Alvarez-Cienfuegos

School of Biological and Marine Sciences Theses

The intertidal environment is a complex and highly dynamic ecosystem shaped by the interaction of strong abiotic and biotic factors. Organisms living in this habitat present marked physiological and behavioural adaptations to cope with extreme and fluctuating conditions, which make this ecosystem the perfect natural laboratory to analyse the effects of biological interactions and physical stressors in ectotherm protein metabolism and growth in the field. Patella vulgata’s ability to maintain aerobic metabolism out of the water, its homing behaviour, its high abundance, and wide geographical distribution facilitates the study of ectothermic physiological processes in the field. Despite the importance of …


Effects Of Host-Derived Probiotics On The Growth Performance And Health Of Tilapia And Carp, Sherilyn Abarra Jan 2025

Effects Of Host-Derived Probiotics On The Growth Performance And Health Of Tilapia And Carp, Sherilyn Abarra

School of Biological and Marine Sciences Theses

To address the need for well-characterised probiotic strains for tilapia and carp aquaculture, this study investigated the isolation, characterisation, and application of host-derived candidate probiotics from Nile tilapia (Oreochromis niloticus) and mirror carp (Cyprinus carpio), and their influence on growth, feed utilisation, intestinal integrity and microbiome, and mucosal health of the host.A total of 263 intestinal bacterial isolates were screened in vitro for antagonism against Aeromonas hydrophila and Streptococcus iniae. The top 31 isolates with inhibitory effects underwent screening against three further fish pathogens and were assessed for haemolytic activity and extracellular enzyme production in …


Metabolic And Kinetic Impacts Of The Auxiliary Energy Source In Model Chemolithoheterotrophic Bacteria, Caleb Yarnley Jan 2025

Metabolic And Kinetic Impacts Of The Auxiliary Energy Source In Model Chemolithoheterotrophic Bacteria, Caleb Yarnley

School of Biological and Marine Sciences Theses

Chemolithoheterotrophy describes a type of microbial metabolism by which organisms oxidise an inorganic electron donor to supplement the generation of an electrochemical gradient. This results in higher overall growth yields and maximum specific growth rates as the organism does not need to generate as many reducing equivalents to fuel the respiratory chain and can instead redirect that material into anabolic reactions to generate more biomass. Many aspects of this metabolism remain poorly understood due to the difficulty in observing genuine chemolithoheterotrophy, with significant increases in the maximum specific growth yield (YMAX) and maximum specific growth rate (µMAX) seen in continuous …


Evidence For Alcohol-Mediated Hemolysis And Erythrophagocytosis, Chaowen Zheng, Siyuan Li, Johannes Mueller, Cheng Chen, Huanran Lyu, Guandou Yuan, Ane Zamalloa, Lissette Adofina, Parthi Srinivasan, Krishna Menon, Nigel Heaton, Stephan Immenschuh, Ines Silva, Vanessa Rausch, Seddik Hammad, Steven Dooley, Shilpa Chokshi, Antonio Riva, Songqing He, Sebastian Mueller Jan 2025

Evidence For Alcohol-Mediated Hemolysis And Erythrophagocytosis, Chaowen Zheng, Siyuan Li, Johannes Mueller, Cheng Chen, Huanran Lyu, Guandou Yuan, Ane Zamalloa, Lissette Adofina, Parthi Srinivasan, Krishna Menon, Nigel Heaton, Stephan Immenschuh, Ines Silva, Vanessa Rausch, Seddik Hammad, Steven Dooley, Shilpa Chokshi, Antonio Riva, Songqing He, Sebastian Mueller

Peninsula Medical School

Alcohol-related liver disease (ALD) is the most common liver disease worldwide; however, its underlying molecular mechanisms remain poorly understood. Here, we identify ethanol-mediated hemolysis and erythrophagocytosis as major contributors to ALD pathogenesis using both in vitro and in vivo models, as well as surrogate markers such as heme oxygenase-1 (HO-1) and CD163, a scavenger receptor for hemoglobin-haptoglobin complexes. A key initial observation was the direct optical evidence of serum hemolysis in heavy drinkers, which diminished after one week of alcohol withdrawal. In parallel, soluble CD163 (sCD163) levels declined during alcohol detoxification correlating with liver damage and fibrosis stages. Moreover, red …


How Epilepsy Risks Might Be Introduced And Discussed In Clinical Consultations, Rohit Shankar Jan 2025

How Epilepsy Risks Might Be Introduced And Discussed In Clinical Consultations, Rohit Shankar

Peninsula Medical School

AbstractAdverse impacts of epilepsy (e.g., injury, depression, and Sudden Unexpected Death from Epilepsy (SUDEP) can be mitigated by factors that patients may control, such as medication adherence, improved sleep and diet, reduced alcohol and taking care around pregnancy. New guidelines state that risk should be discussed at the time of diagnosis but some clinicians express concern about not wanting to raise anxiety.ObjectiveTo explicate practices by which epilepsy expert clinicians broach discussions of risk in specialist epilepsy clinics.Methods24 recordings of initial telephone appointments at specialist clinics where epilepsy is diagnosed from two specialist outpatient epilepsy services in England were subjected to …


Epidemiology Of Thrombotic Thrombocytopenia Syndrome 2011 To 2022: English Sentinel Network Cohort Studies, José M. Ordóñez-Mena, Debasish Kar, Xuejuan Fan, Filipa Ferreira, Sneha N. Anand, Deborah Layton, David Clifton, Mark Joy, Anshul Thakur, Anu Alessi, Andrew Lee, Lisa Mather, Simon De Lusignan Jan 2025

Epidemiology Of Thrombotic Thrombocytopenia Syndrome 2011 To 2022: English Sentinel Network Cohort Studies, José M. Ordóñez-Mena, Debasish Kar, Xuejuan Fan, Filipa Ferreira, Sneha N. Anand, Deborah Layton, David Clifton, Mark Joy, Anshul Thakur, Anu Alessi, Andrew Lee, Lisa Mather, Simon De Lusignan

Peninsula Medical School

Background and Objective: Thrombotic thrombocytopenia syndrome (TTS) is a rare condition following vaccination with adenovirus-vectored coronavirus disease 2019 (COVID-19) vaccines. This retrospective analysis of England primary care data aimed to estimate TTS event rates before, during, and after the COVID-19 pandemic, and following AZD1222 (ChAdOx1-nCoV-19) vaccination. Methods: Primary care data on TTS events were collected using the Oxford-Royal College of General Practitioners Research and Surveillance Centre sentinel network. TTS events were defined as thromboembolism with coincident (± 7 days) thrombocytopenia events using Systematized Nomenclature of Medicine clinical terms (the current Brighton Collaboration definition could not be used in the study …


Consensus-Based Research Priorities For Post-Collision Care In The Western Cape Province Of South Africa, Naseef Abdullah, Tim Nutbeam, Colleen J. Saunders, Craig Wylie, Nigel Lang, Willem Stassen Jan 2025

Consensus-Based Research Priorities For Post-Collision Care In The Western Cape Province Of South Africa, Naseef Abdullah, Tim Nutbeam, Colleen J. Saunders, Craig Wylie, Nigel Lang, Willem Stassen

Peninsula Medical School

Introduction: Road traffic injuries constitute a significant global health burden, causing 1.3 million deaths and 50million injuries annually, with 92 % of fatalities occurring in low-and middle-income countries (LMICs). Despitethis disproportionate impact, research priorities in post-collision care often reflect high-income country contexts,creating a critical misalignment between evidence generation and contextual realities in LMICs.Methods: This mixed-methods study employed a three-phase approach to identify research priorities for postcollision care in the Western Cape, South Africa. Phase 1 consisted of a comprehensive literature review toidentify preliminary thematic areas and research questions. Phase 2 involved a stakeholder engagement workshop using modified nominal group techniques …