Digital Commons Network^™

Molecular Alterations In Idh-Mutant Astrocytoma: A Multi-Institutional Retrospective Study, Keng Lam, Hanim I Ozkizilkaya, Denái R Milton, Antonio Dono, Yajie Liu, Suprateek Kundu, Vinodh A Kumar, Jason M Johnson, Yoshua Esquenazi, Chirag B Patel, Leomar Y Ballester

Faculty, Staff and Student Publications

Background: Several molecular alterations have been identified to provide prognosis for patients with isocitrate dehydrogenase (IDH)-mutant astrocytoma. However, contemporary baseline survival data with respect to their molecular alterations are lacking. The prognostic value of histologic grading remains controversial.

Methods: This was a retrospective multi-site study of adult IDH-mutant diffuse astrocytoma patients. Overall survival (OS) was estimated using the Kaplan-Meier method. Associations between OS and measures of interest were evaluated using Cox proportional hazards regression models.

Results: We identified 241 eligible patients. The most frequent mutations were IDH1 (98%), TP53 (91%), ATRX (70%), ARID1A (8%), BRCA2 (6%), TSC2 (6%), CDKN2A (6%), …

The Impact Of Post-Remission Granulocyte Colony-Stimulating Factor Use In The Phase 3 Studies Of Venetoclax Combination Treatments In Patients With Newly Diagnosed Acute Myeloid Leukemia, Courtney D Dinardo, Keith W Pratz, Panayiotis Panayiotidis, Xudong Wei, Vladimir Vorobyev, Árpád Illés, Inho Kim, Vladimir Ivanov, Grace Ku, Catherine L Miller, Meng Zhang, Fernando Tatsch, Jalaja Potluri, Xenia Schmidt, Christian Récher

Faculty, Staff and Student Publications

No abstract provided.

Electrical Characterization Of The Alleged Bio-Memristor Physarum Polycephalum, Markus Schmidt, Günter Seyfried, Uliana Reutina, Zeki Seskir, Eduardo R. Miranda

School of Art, Design and Architecture

This study investigates the potential of the slime mold Physarum polycephalum to function as a bio-memristor. In contrast to earlier reports, our experimental results did not show a significant memristive behavior. Instead, all tested slime molds exhibited elliptical I-V characteristics, attributed to their inherent capacitance. To model this behavior, we developed replacement circuits consisting solely of resistors and capacitors, which accurately reproduced the observed results. While these circuits lack memristive properties, they demonstrate potential utility as sub-circuits in analog applications, such as filters, timing circuits, and phase shift networks. Despite it not being a memristor, P. polycephalum may hold promise …

Balancing Nature And Tradition: Ocean Governance In The Noosa World Surfing Reserve, Kizzy Beaumont, Kirra Molnar, Michael Court

School of Art, Design and Architecture

Executive summary This report captures insights from focus groups and interviews held in Noosa in September 2024 as part of ongoing research into Transformative Ocean Governance. Participants shared reflections on the successes and struggles of the Noosa World Surfing Reserve (WSR) and outlined visions for its future.The WSR was praised for its cultural importance, environmental values, and grassroots leadership, but concerns were raised about crowding, tourism pressure, outdated policies, and fragmented governance. Participants highlighted gaps in environmental and surf-amenity data, funding shortages, and limited capacity to engage diverse community voices. Governance overlaps between the WSR, Council, and Biosphere Reserve have …

Mental Silence For Emotional Intelligence Development, Mina N. Nandwani

Theses and Dissertations

While emotional intelligence is considered key for effective leadership, and perhaps the most vital competency for current and emerging leaders to cultivate, there appears to be uncertainty on how to develop it. This study examined how the practice of Sahaja Yoga Meditation (SYM) influences the development of emotional intelligence and contributes to the advancement of global leadership capacities, addressing a gap in the current literature. The conceptual frameworks of SYM, Daniel Goleman’s Emotional Intelligence Model, and the literature on global leadership, particularly Jeffrey Sachs’ Ages of Globalization, guided the research question. By implementing a qualitative phenomenological research approach, ten long-time …

Il-7: A Potential Next-Generation Adjuvant For Immune Cell Therapies, Richard S Hotchkiss, John F Dipersio, Cassian Yee, Russell K Pachynski, Marcel R M Van Den Brink

Faculty, Staff and Student Publications

Cell-based immune therapies ranging from CAR-T cells to tumor infiltrating lymphocytes (TILs) and endogenous T-cell products, have produced unprecedented clinical responses in hematologic malignancies and are currently under active investigation for solid tumors. Nevertheless, several key challenges continue to limit the durability and breadth of clinical benefit. IL-7 is a pleiotropic cytokine that increases both the number and function of lymphocytes. Although not yet clinically approved, IL-7 has been used in over 620 adult and pediatric patients for a variety of reasons including, for example, to hasten bone marrow recovery after allogenic stem cell transplantation, to reverse lymphopenia due to …

Understanding The Evolution Of The Apical Organ In The Early Branching Metazoan, Nematostella Vectensis, Eleanor Gilbert

School of Biological and Marine Sciences Theses

The apical organ is a key sensory structure in marine invertebrate larvae that is involved in sensory processing and neural coordination, thereby influencing larval locomotion, settlement, and metamorphosis. This thesis explores the evolution, development, and function of the apical organ and wider apical domain in cnidarian larvae, with a particular focus on Nematostella vectensis. As an early-branching metazoan, N. vectensis is a unique model for studying evolution of the apical organ, and subsequently the origins of the nervous system. Through generating tissue-specific transcriptomes and integrating this data with an existing single-cell RNA sequencing dataset, this research identified a distinct neuronal …

Benefits And Challenges With The Modular Model Of Teacher Certification In Australia: Listening To Teachers’ Voices, Bernard Brown, Rohan Nethsinghe

Australian Journal of Teacher Education

This paper examines teachers’ views about the Highly Accomplished and Lead Teacher (HALT) Certification 2.0 Modular Model (CMM 2.0). The research reveals teachers’ voices and agency in relation to HALT certification. Participants in this study included HALT certified teachers, current HALT participants, and prospective participants. The semi-structured interviews conducted provide insights into the benefits and challenges associated with the CMM 2.0. Thematic coding and systematic analysis were applied to the data to arrive at the key findings. The research revealed that teachers believed that the modular approach was advantageous as it was flexible and provided professional recognition and development. Issues …

Challenging Assumptions: Ai And Teacher Assessment Identity Formation, Nadia Ollington

Australian Journal of Teacher Education

This article explores the ways in which teacher educators can strengthen the developing teacher assessment identity of preservice teachers who are at the precipice of Industry 4.0, where work with Artificial Intelligence (AI) and assessment will require flexible thinking. This reflective case study narrative outlines a teacher educator’s experiences in a novel assessment task using Generative AI for technology enhanced learning in an Australian postgraduate teaching program. In the task, those who held positive beliefs and emotions about AI were more likely to engage in flexible thinking skills than those who were more critical of the AI. To ensure that …

Changes In Mentor Teacher Participation In Postgraduate Secondary Initial Teacher Education: Climatic Conditions Preceding Workforce Reform., Alison L. Hilton, Chad Morrison, Felicity I. Mclure, Kathryn G. Dehle, Sandi Fielder

Australian Journal of Teacher Education

Professional Experience placements provide invaluable opportunities for pre-service teachers to connect their expanding knowledge to teaching practice. When done well, these experiences are underpinned by purposeful and continuous guidance from experienced mentor teachers. Significantly, the participation and engagement of Australian mentor teachers in this process is voluntary in nature, meaning the system relies on teachers ‘opting-in’ to mentoring. This research examines mentor teacher participation within Secondary-level initial teacher education courses and highlights issues relating to overall mentor teacher (and host school) engagement. Analysis of placement data over a five-year period to 2021 illustrates a significant change in participation with a …

From Guesswork To Growth: Understanding How Preservice Teachers Interpret And Enact Appraisal Within A Teacher Performance Assessment, Allison Byth, Thembi Mason, Laurie Werrett

Australian Journal of Teacher Education

In Australia, the Graduate Teacher Performance Assessment (GTPA) is a capstone summative assessment evaluating preservice teachers ‘classroom readiness’ across five practices: planning, teaching, assessing, reflecting and appraising. In our work with preservice teachers, appraising the impact of teaching emerged as the most conceptually and practically challenging practice. To understand how preservice teachers interpreted and enacted appraisal, this exploratory case study analysed 15 GTPA submissions that met standards in the first four practices but not in appraisal. The findings highlight common issues, including conflating appraisal with general reflection, difficulty interpreting and applying data meaningfully, and presenting narrative accounts rather than evaluative …

Fostering Learner Autonomy In Efl Setting Through Multiliteracy Pedagogy: A Case In Tertiary Education, Desi Surlitasari Dewi, Rudi Hartono, Sri Wahyuni, Sri Lestari

Australian Journal of Teacher Education

The intersection of learner autonomy and multiliteracy pedagogy in EFL settings remains underexplored. To address this gap, this study investigates how multiliteracy pedagogy fosters learner autonomy in the EFL context. The study involved 24 university students majoring in English, for whom English was primarily a third language. The participants attended an intermediate speaking course, a compulsory class in their curriculum. A learner autonomy questionnaire was administered to measure autonomy in the EFL speaking context before and after the implementation. Additionally, semi-structured interviews and classroom observations enriched the data. The findings indicate a significant improvement in learner autonomy following the implementation …

Raising Information Literacy Of Biology Pre-Service Teachers: Study On Three Problem Solving Methods, Muhammad Saefi, Hadi Suwono, Rifka Fachrunnisa, Widi Cahya Adi, Herawati Susilo, Ahmad Kamal Sudrajat

Australian Journal of Teacher Education

Integrating information literacy teaching methods with subject-content curricula to develop prospective biology teacher students' abilities is still problematic. This quasi-experimental research, with a nonrandomized pretest-posttest control group design, intends to compare the influences of challenge-based learning (CBL), problem-based learning (PBL), and problem-solving through classroom discussion (PCD) – as the control- in improving information literacy. This study involved 183 students from three classes of freshmen and three sophomores in the biology education program. The results showed that CBL significantly improved students' information literacy compared to PBL and PCD across five indicators: 1) identifying the required information, 2) attaining the required information …

Teacher Resilience In South Africa: The Self-Efficacy And Teacher Efficacy Of Pre-Service Teachers Preparing To Teach In A Challenged Context, Carine Jonker, Marien Alet Graham, Liesel Ebersöhn

Australian Journal of Teacher Education

This publication addresses a gap in high-quality, quantitative studies on teacher resilience within the less-researched context of the Global South. Specifically, it examines the self-efficacy and teacher efficacy of three cohorts of final-year pre-service teachers in South Africa (N = 1,193). This article aimed to contribute evidence on teacher resilience from an under-researched African context and population. Despite contextual challenges, the pre-service teachers indicated high intrapersonal resilience-enabling pathways, with a statistically significant relationship between their self-efficacy and teacher efficacy. The authors propose an evidence-based framework of how high levels of self-efficacy and teacher efficacy may enable prospective teachers to teach …

A Qualitative Exploration Of Changes In English Language Teachers’ Perceptions Of Their Agency Through Engaging In Action Research, Khadije Aqajani Delavar, Mohammad R. Hashemi, Mohammad Nabi Karimi

Australian Journal of Teacher Education

While research on language teachers’ engagement in action research (AR) has received a surge of attention, the influence of AR programs on English language teacher agency remains under-examined. This qualitative study explored how ten English language teachers’ perceptions of their agency changed as they participated in an action research engagement program (AREP). Data were collected using semi-structured interviews and reflective journals. The findings revealed that participation in the AR program changed the teachers’ perceptions of their agency and empowered them to enact higher levels of agency in their classroom practice. The study also highlights the important role of institutional support …

Deep Learning For Precise Mri Segmentation Of Lower-Grade Gliomas, Wusat Ullah, Hamza Naveed, Saalam Ali

Sustainable Machine Intelligence Journal

Brain tumors represent a significant public health issue worldwide, affecting individuals across all age groups and leading to severe neurological and cognitive deficits. Lower-grade gliomas (LGGs), classified by the World Health Organization (WHO) as grade II or III, are characterized by more diffuse infiltration into brain tissue compared to high-grade gliomas but exhibit a slower growth rate. Precise evaluation of tumor resection and detection of residual tumor cells are critical, as incomplete resection is associated with an increased risk of disease recurrence. This study reviews an automated, deep learning-based approach for brain tumor segmentation in Magnetic Resonance Imaging (MRI) using …

Advanced Fruit Quality Assessment Using Deep Learning And Transfer Learning Technique, Walid Abdullah

Sustainable Machine Intelligence Journal

Ensuring the quality of fruits is essential for consumer satisfaction and food industry standards. Accurately identifying and classifying high-quality fruits is essential for maintaining good health and nutrition. The subjective and labor-intensive nature of traditional techniques of evaluating quality highlights the need for automated solutions. This study utilized transfer learning with Four pre-trained convolutional neural network (CNN) models—MobileNetV2, ResNet50, VGG16, and EfficientNetB0 —to detect the quality of five fruits: apple, banana, strawberry, orange, and mango. All models were trained and tested with a public labeled fruit images dataset, and their performance was evaluated in terms of accuracy, precision, recall, and …

A Hybridized Cnn-Lstm-Mlp-Knn Model For Short-Term Solar Irradiance Forecasting, Doaa El-Shahat, Ahmed Tolba

Sustainable Machine Intelligence Journal

The accurate prediction of solar irradiance is essential for maximizing renewable energy production. Despite some researchers struggling to achieve sufficient prediction accuracy and model quality, we are working on developing a forecasting model for solar radiation using advanced artificial intelligence techniques. Solar energy offers a sustainable alternative to fossil fuels and has a wide range of applications, making the development of an effective forecasting model crucial. This paper proposes a hybrid model that combines deep learning and machine learning methods, denoted as CNN-LSTM-MLP-KNN. By combining Convolutional Neural Network (CNN), Long Short-Term Memory (LSTM), Multilayer Perceptron (MLP) and K-Nearest Neighbors (KNN), …

Enhancing Software Effort Estimation In Healthcare Informatics: A Comparative Analysis Of Machine Learning Models With Correlation-Based Feature Selection, Muhammad Abid, Sama Bukhari, Muhammad Saqlain

Sustainable Machine Intelligence Journal

Software effort estimation is one of the most crucial processes in the management of software projects predominantly related to the healthcare industry. It involves the prediction of efforts needed to develop and endorse different software applications. To render clinical projects on time within the budget range, flawless projection with efficient planning is incumbent. This paper discloses the techniques that utilize machine learning models for ameliorating software effort estimation by using biomedical datasets, including Breast Cancer Wisconsin, COVID-19, Sleepy Drivers EEG Brainwave, Heart Disease Prediction and Food Nutrition. All of these datasets are cleaned and prepared by handling missing values, converting …

A Decolonial And Liberation Lens To Social Justice Research: Upholding Promises For Diverse, Inclusive, And Equitable Psychological Science, Luz M. Garcini, Aldo Barrita, German Cadenas, Melanie M. Domenech Rodriguez, Thania Galvan, Alfonso Mercado, Oswaldo Moreno, Manuel Paris, Oscar F. Rojas Perez, Michelle Silva, Amanda Venta

Psychological Science Faculty Publications

In the face of harmful disparities and inequities, it is crucial for researchers to critically reflect on methodologies and research practices that can dismantle systems of oppression, accommodate pluralistic realities, and facilitate opportunities for all communities to thrive. Historically, knowledge production for the sciences has followed a colonial and colonizing approach that continues to silence and decontextualize the lived experiences of people of color. This article acknowledges the harm to people of color communities in the name of research and draws from decolonial and liberation frameworks to advance research practices and psychological science toward equity and social justice. In this …

The Role Of Complex Posttraumatic Stress Disorder In The Associations Between Minority Stressors And Self-Reported Suicide Likelihood In Lgbtq+ Adults., Ines Cano-Gonzalez, Ruby Charak, Roman Ronzon-Tirado, Jorge I. Cantu

Psychological Science Faculty Publications

Lesbian, gay, bisexual, trans, and queer individuals (LGBTQ+) report higher rates of suicide-related behaviors when compared to heterosexual cisgender individuals. The minority stress theory proposes that the suicide risk disparities among LGBTQ+ individuals may be explained by the additional exposure to stressors unique to their minority sexual orientation and gender identity. However, less is known about the mechanism of minority stressors and suicide risk among trauma-exposed LGBTQ+ individuals. The present study aimed to explore the role of the International Classification of Diseases, version-11 posttraumatic stress disorder (PTSD) and complex PTSD (disturbances in self-organization [DSO] + PTSD) in the associations between …

An Hplc-Ms/Ms Method For The Quantification Of Heat Stress-Related Milk Metabolites In Milk From Holstein-Friesian Cross-Bred Cows In Tanzania, Vincent Habimana, A.S Nguluma, Z.C Nziku, C.C Ekine-Dzivenu, G Morota, R Mrode, S.W Chenyambuga

All Rsif Scholars' Publications

The main objective of this study was to develop and validate a high-performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS) method for the determination and quantification of three metabolites in raw milk samples: creatinine, citrate, and β-hydroxybutyrate (3-BHB). The effect of the temperature-humidity index (THI) on the concentrations of these metabolites was also investigated. The study used 29 Holstein-Friesian × Tanzanian Shorthorn Zebu cross-bred cows of two genotypes from the Tanzania Livestock Research Institute in Tanga, Tanzania. The cows were in their second or third parity and their second or third month of lactation. Chromatographic separation of the three metabolites was performed …

Climate-Driven Shifts In The Geographic Distribution Of Fodder Trees In West AfricaʼS Grazing Landscapes, Idrissa Sawadogo, Philippe Bayen, Larba Hubert Balima, Charles Lamoussa Sanou, Faustine Akossoua Kouassi, Omonlola Nadine Worou

All Rsif Scholars' Publications

West African pastures host several valuable fodder tree species which are essential for livestock rearing. Among these, Cordyla pinnata and Boscia senegalensis play a particularly significant role in the region’s landscape, providing both food products and high-quality fodder for livestock. However, these species face an increase anthropogenic threat, which compromises their long-term availability. Despite their importance, little is known about their spatial distribution under changing climatic conditions in West Africa. This study, we assessed the impact of climate change on the geographic distribution of Cordyla pinnata and Boscia senegalensis in Burkina Faso. Presence data comprising 306 records of C. pinnata …

Petrophysical And Petrographic Characterisation Of The Reservoirs In Niger Delta For Carbon Capture And Storage, Itai Mutadza, Sunday Ikiensikimama, Ogbonna F. Joel

All Rsif Scholars' Publications

The unprecedented levels of carbon dioxide in the atmosphere are linked to the rising average temperatures that the world is experiencing. Carbon sequestration in geological formations is one of the key strategies to combat climate change. However, it is essential to characterise these geological formations to assess the potential success of environmentally friendly carbon sequestration. Controlling carbon sequestration and its migration within porous sandstones is largely dependent on the textural and geometrical characteristics of the pore networks, including tortuosity, connectivity, pore size distribution, and pore shape. Microstructural analysis of the reservoirs helps reduce risks and uncertainties associated with carbon …

Estimation Of Genetic Parameters For Physiological And Milk Production Traits Of Holstein Friesian Crossbreds Reared In Tanzania, Vincent Habimana, Chinyere Charlotte Ekine-Dzivenu, Athumani Shabani Nguluma, Zabron Cuthibert Nziku, Gota Morota, Sebastian Wilson Chenyambuga, Raphael Mrode

All Rsif Scholars' Publications

The main objective of this study was to estimate the genetic parameters for physiological traits, milk yield, and milk composition in Holstein Friesian crossbred cattle raised at the Tanzania Livestock Research Institute’s (TALIRI) Tanga dairy farm. A total of 29 lactating Holstein Friesian × Zebu crossbred cows with 50% (HF50) and 75% (HF75) Holstein Friesian gene levels in their second and third months of lactation were included. Breed composition was determined based on the animal recording system at TALIRI, Tanga. A series of univariate and bivariate repeatability (r) test-day models was used to estimate genetic parameters, genetic (rg) and phenotypic …

Development Of High-Performance Basalt Fiber-Reinforced Polymer Composite Using A Nanocellulose-Based Surface Modification Strateg, Abdulrahman Adeiza Musa, Junha Park, Gonui Hong, Soon Ho Yoon, Azikiwe Peter Onwualu, Minkook Kim

All Rsif Scholars' Publications

Basalt fibers (BFs) have emerged as a promising alternative reinforcement material for developing fiberreinforced polymer (FRP) composites, due to their lower environmental impact compared with traditional fibers such as carbon and glass. However, the weak interfacial bonding between BFs and the polymer matrix limits the mechanical performance of basalt fiber-reinforced polymers (BFRPs). In this work, nanocelluloses (NCs), including cellulose nanofiber (CNF) and cellulose nanocrystal (CNC), were investigated as bio-based interfacial modifiers to enhance fiber–matrix adhesion and improve the mechanical performance of BFRP. While direct incorporation of NC into epoxy resin is challenging due to its poor dispersibility in hydrophobic media, …

Effect Of Malt Barley Cluster Farming On Food Security In Amhara Region, Ethiopia, Betelhem Tsedalu Adane, Irene Susan Egyir, Edward Ebo Onumah, Ama Asantewah Ahene-Codjoe, Taeyoon Kim

All Rsif Scholars' Publications

Cluster farming is the practice of merging neighbouring farms into a unified production unit to grow specific crops collaboratively. This is a promising method to enhance food security by improving agricultural productivity through coordinated resource use and enabling access to inputs, technologies, and markets. Despite this benefit, no empirical studies have examined how malt barley cluster farming affects smallholder farmers’ food security. This study adopts descriptive and econometric analysis, including the endogenous switching regression model (ESRM) and control function approach to account for selection bias and endogeneity in estimating the causal effect of malt barley cluster farming. Cross-sectional data were …

Preliminary Investigation On Nigerian Lithium Ores For Efficient Lithium Oxide Extraction, Olajuyi Seun Isaiah, Afolayan David Oluwasegun, Ogunmodimu Samuel Olumide

All Rsif Scholars' Publications

This paper assesses the compositions of the lithium-rich minerals and the quantity of extractable lithium oxide in the minerals. The x-ray diffraction (XRD) shows 17% - 34% of spodumene and 9% to 30% of lepidiolite. Similarly, atomic absorption microscopy (AAS) indicates that the lithium-rich minerals contain 0.820% - 3.051% and 0.040 - 2.395% of lithium oxide (Li2O). Further results confirm the presence of lithium-rich minerals in Nigeria, and a high quantity of lithium-rich minerals suggests that high lithium oxide can be extracted. This information is useful for miners, mining and mineral processing industries, and investors in lithium for different industrial …

Mechanistic Insights Into Nigerian Lithium Ores: Implications For Energy And Industrial Applications, Seun Isaiah Olajuyi, Hassan Adamu Abubakar, O. S Ogunmodimu, D. O . Afolayan

All Rsif Scholars' Publications

Lithium is a critical element in battery technology for renewable energy storage applications. The mineral offers potential solutions to the current surge in global energy demand and can position Nigeria as a potential key player in the lithium supply chain. However, little to nothing is known of the lithium deposits in Nigeria. This review explores the formation, geology, and ongoing exploration activities of lithium in Nigeria. The study provides an overview of the geological settings and mineralogical characteristics of the Nigerian lithium-bearing pegmatites and ores, comparing them with global deposits. It also examines current lithium mining and processing techniques, identifies …

The End(S) Of Bankruptcy Exceptionalism: Purdue Pharma And The Problem Of Social Debt, Pamela Foohey, Jonathan C. Lipson

Scholarly Works

The Supreme Court’s recent 5-4 decision in the controversial chapter 11 bankruptcy reorganization of opioid-maker Purdue Pharma ends the use of nonconsensual third-party “releases,” which discharge (eliminate) liabilities of non-debtors who may share liability with a corporate debtor. Although the majority opinion is correct that the Bankruptcy Code does not permit this, it failed to recognize the problematic exceptionalism of the lower courts which approved those releases or the “social” qualities of Purdue Pharma’s mass tort liability.

Bankruptcy exceptionalism has been a contested concept since it emerged over fifteen years ago, and reflects a willingness to bend the rule of …