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2025

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The Influence Of Project Managing Capability, It Integration, Supply Coordination, And Process Innovation To Improve Organizational Performance Of Educational Institutions, Ellysa Sri Hartati, Hotlan Siagian, Zeplin Jiwa Husada Tarigan, Ferry Jie Jan 2025

The Influence Of Project Managing Capability, It Integration, Supply Coordination, And Process Innovation To Improve Organizational Performance Of Educational Institutions, Ellysa Sri Hartati, Hotlan Siagian, Zeplin Jiwa Husada Tarigan, Ferry Jie

Research outputs 2022 to 2026

The organization strives to provide timely service according to customer needs. Organizations must communicate and make the right decisions quickly to improve performance. The research aims to assess the influence of project management capability, integration, and coordination in improving organizational performance. Data is collected using a questionnaire designed with a five-point Likert scale. The respondents are all suppliers or vendors of high school educational Institutions in East Java. The organization has a project manager responsible for all procurement and projects. The criteria of suppliers or vendors are those who have paid taxes, have a taxpayer number, and have an adequate …


Education For Sustainable Development: An Assessment Of Australian And Canadian Business Schools, Eduardo Ordonez-Ponce, Mehran Nejati, Rahatulaain Ahmad Jan 2025

Education For Sustainable Development: An Assessment Of Australian And Canadian Business Schools, Eduardo Ordonez-Ponce, Mehran Nejati, Rahatulaain Ahmad

Research outputs 2022 to 2026

Purpose: This study aims to investigate whether and how business schools in Australia and Canada advocate for education for sustainable development. Design/methodology/approach: This exploratory study used a sequential mixed methods design, using a combination of qualitative content analysis and thematic analysis. During phase 1, sustainability reports developed by Australian and Canadian business schools (SIP reports), which are signatories to the Principles for Responsible Management Education (PRME), were reviewed using qualitative content analysis methods. Following that, a thematic analysis of semi-structured interviews with nine representatives from selected business schools from Australia and Canada were conducted to triangulate and interpret the findings …


Empowerment Through Choice: The Interplay Of Choice And Control After Spinal Cord Or Brain Injury, Gisela Van Kessel, Shylie Mackintosh, Carolyn M. Murray, Michelle Guerin, Caroline Elizabeth Fryer, Mandy Stanley Jan 2025

Empowerment Through Choice: The Interplay Of Choice And Control After Spinal Cord Or Brain Injury, Gisela Van Kessel, Shylie Mackintosh, Carolyn M. Murray, Michelle Guerin, Caroline Elizabeth Fryer, Mandy Stanley

Research outputs 2022 to 2026

Purpose: To gain knowledge of the early phase post-injury experiences related to choice and control for individuals living with acquired brain injury or spinal cord injury, as well as their caregivers. Materials and Methods: A qualitative study was conducted to understand the experiences of individuals with acquired brain injury or spinal cord injury and their caregivers in the early phase post-injury, focusing on the aspects of choice and control. Nine individuals with acquired brain injury or spinal cord injury and four of their caregivers participated in semi-structured in-depth interviews, and the data was analysed using thematic analysis. Results: Four themes …


Flexible Furniture To Support Inclusive Education: Developing Learner Agency And Engagement In Primary School, Julia E. Morris, Wesley Imms Jan 2025

Flexible Furniture To Support Inclusive Education: Developing Learner Agency And Engagement In Primary School, Julia E. Morris, Wesley Imms

Research outputs 2022 to 2026

To ensure quality and equitable education requires an understanding of how all learners function within a learning environment, and the ways in which teachers’ pedagogy can support inclusive practice. Drawing on research from a rural school in Western Australia, this paper identifies how furniture can be used as a tool to support student agency and opportunity to meet individual learning needs. Across two years, the study employed a single-subject research design to explore the impact of differing furniture arrangements on students’ agency and engagement, as well as teacher pedagogies. It used both quantitative and qualitative repeated measures with 9 teachers …


Multifactorial Fall Interventions For People Over 65 Years In The Acute Hospital Setting: Pre–Post-Test Design, Allison Wallis, Christina Aggar, Deb Massey Jan 2025

Multifactorial Fall Interventions For People Over 65 Years In The Acute Hospital Setting: Pre–Post-Test Design, Allison Wallis, Christina Aggar, Deb Massey

Research outputs 2022 to 2026

Background: Falls are the most reported patient safety incident for patients >65 years in acute hospital settings worldwide. While multifactorial fall interventions reduce the number of falls in subacute and rehabilitation settings, fall interventions in acute hospital settings are unknown. Aim: To evaluate the effectiveness of multifactorial fall interventions on the number of falls using codesigned education targeting staff and the patient and review the environment in acute hospital settings in NSW, Australia for patients over 65 years of age. Method: A pre–post-test design with a non-equivalent group was conducted. All acute hospital inpatient falls occurring both pre- and post-intervention …


Senior Registered Nurses' Organisational Communication Satisfaction, Job Satisfaction, Burnout, And Intention To Stay: A Cross-Sectional Study Of Two Healthcare Groups, Gemma Doleman, Kaoru Nosaka, Annemarie De Leo Jan 2025

Senior Registered Nurses' Organisational Communication Satisfaction, Job Satisfaction, Burnout, And Intention To Stay: A Cross-Sectional Study Of Two Healthcare Groups, Gemma Doleman, Kaoru Nosaka, Annemarie De Leo

Research outputs 2022 to 2026

Aim: To explore organisational communication satisfaction and its impact on senior registered nurses' job satisfaction, burnout, and intention to stay. Design: A cross-sectional design using surveys. The study was conducted with senior registered nurses across two healthcare groups in Western Australia. Results: One hundred seventy-four usable surveys were returned. The results of this study indicated that those with higher communication satisfaction levels were more likely to have higher levels of job satisfaction. Senior registered nurses who intended to leave their jobs had a higher risk of emotional exhaustion and depersonalisation, which may result in higher rates of burnout compared to …


The Impact Of Practicum Job Demands And Resources On Pre-Service Teachers’ Occupational Commitment And Job Intent, Jeremy Pan, Tony Loughland, Rebecca J. Collie, Andrew A. Kingsford-Smith, Mary Ryan, Caroline Mansfield, Rachelle Davey, Chrissy Monteleone, Miriam Tanti Jan 2025

The Impact Of Practicum Job Demands And Resources On Pre-Service Teachers’ Occupational Commitment And Job Intent, Jeremy Pan, Tony Loughland, Rebecca J. Collie, Andrew A. Kingsford-Smith, Mary Ryan, Caroline Mansfield, Rachelle Davey, Chrissy Monteleone, Miriam Tanti

Research outputs 2022 to 2026

Around the world, there is a need to understand how to support pre-service teachers through their initial teacher education (ITE). The current study applied the Job Demands-Resources Theory to examine the associations among Australian pre-service teachers’ job demands and resources. The structural equation modelling found that perceived autonomy support, and relatedness with colleagues and students, were positively related to work outcomes of occupational commitment and job intent. Conversely, factors like disruptive student behaviour and time pressure were negatively associated with these outcomes. These findings suggest the relevance of providing support mechanisms for pre-service teachers to enhance their important ITE phase.


Transnational Grandparent Migration And Care-Giving: A Systematic Scoping Review, Hien Thi Nguyen, Catriona Stevens, Loretta Baldassar Jan 2025

Transnational Grandparent Migration And Care-Giving: A Systematic Scoping Review, Hien Thi Nguyen, Catriona Stevens, Loretta Baldassar

Research outputs 2022 to 2026

Grandparents are increasingly participating in international migration to resettle with or visit adult children and grandchildren living overseas. In doing so, they make important social, cultural, emotional and financial contributions to transnational families, in particular through providing unpaid childcare and domestic work. This scoping review aims to examine the extent, range and nature of studies on transnational grandparent migration and care-giving to provide an overview of existing research. The review was conducted in August 2022, following Arksey and O’Malley’s scoping review methodology. Of 2,099 sources identified using nine databases, supplemented with manual searching (including grey literature), 65 (qualitative, quantitative and …


Young Children Moving Through Ecological Anxiety And Grief: Dancing With Demolition, Jane Merewether, Jo Pollitt, Mindy Blaise Jan 2025

Young Children Moving Through Ecological Anxiety And Grief: Dancing With Demolition, Jane Merewether, Jo Pollitt, Mindy Blaise

Research outputs 2022 to 2026

As the extent of planetary unraveling becomes increasingly apparent, scholars are beginning to document responses to the loss of ecological systems, mass extinctions, and climate change. However, there are few studies documenting children’s eco-anxiety responses. In this study, children’s eco-anxiety and grief became apparent when they expressed dismay at the imminent demolition of a derelict building. Children were concerned for the fate of the building, the land on which it stood, and the myriad others it sheltered. Using participatory and creative methodologies including dance, this project worked with children to tell a more-than-human story of becoming-with children-building-weeds-graffiti-dust-researchers-unhoused-bacteria-rats-and unloved others, which …


Sources Of Sexual Knowledge And Information, And Sexual Attitudes Of Men: A Narrative Synthesis Of The Literature, Darlene Mwende Ndasi, Victor Fannam Nunfam, Kwadwo Adusei-Asante, Madalena Grobbelaar, Anh Vo Van Ha Jan 2025

Sources Of Sexual Knowledge And Information, And Sexual Attitudes Of Men: A Narrative Synthesis Of The Literature, Darlene Mwende Ndasi, Victor Fannam Nunfam, Kwadwo Adusei-Asante, Madalena Grobbelaar, Anh Vo Van Ha

Research outputs 2022 to 2026

This study sought to synthesise evidence on the sources of sexual knowledge and information and relationship with sexual attitudes of cis men. From a review of existing literature, five categories were obtained from 11 studies and grouped into three syntheses: (1) sources of sexual knowledge and information, (2) sexual attitudes and (3) the relationship between sources of sexual knowledge and information and sexual attitudes. Sex research relation to sexual knowledge and attitudes of cis men is scant across the globe. Men desire reliable sexual information despite peers and online media being more readily available with consequences for sexual attitudes that …


The Development Of A Family-Led Novel Intervention For Delirium Prevention And Management In The Adult Intensive Care Unit: A Co-Design Qualitative Study, Gideon U. Johnson, Amanda Towell-Barnard, Christopher Mclean, Beverley Ewens Jan 2025

The Development Of A Family-Led Novel Intervention For Delirium Prevention And Management In The Adult Intensive Care Unit: A Co-Design Qualitative Study, Gideon U. Johnson, Amanda Towell-Barnard, Christopher Mclean, Beverley Ewens

Research outputs 2022 to 2026

Aim: The aim of this study was to codesign a Family Members’ Voice Reorientation Intervention (FAMVR) for delirium prevention and management in critically ill adult patients through collaborative process with previous patients, families, and clinical staff. Background: Delirium is a common consequence of intensive care admission, and there is limited evidence to support family-led interventions to prevent or minimise delirium in intensive care. People with lived experience of intensive care are seldom involved in codesigning delirium prevention and management interventions despite the identified benefits of their involvement in delirium care. Design: Codesign qualitative study. Methods: The process of co-designing was …


Methylene Blue Adsorption On Y-Zeolite As A Nano-Porous Adsorbent: Equilibrium And Kinetic Studies, Mehdi Narimani, Maryam Gonbadi, Mohammad Mahdi Zerafat Jan 2025

Methylene Blue Adsorption On Y-Zeolite As A Nano-Porous Adsorbent: Equilibrium And Kinetic Studies, Mehdi Narimani, Maryam Gonbadi, Mohammad Mahdi Zerafat

Research outputs 2022 to 2026

The elimination of dye pollutants from industrial wastewaters, notably from sectors such as textiles and dyeing, remains a pivotal aspect of pollution mitigation endeavours. This research introduces an innovative strategy employing Y zeolite as a nano-porous adsorbent for eliminating methylene blue (MB), a prevalent cationic dye. Y zeolite was synthesised via hydrothermal technique. Through methodical experimentation, the impact of temperature, contact time, concentration, pH and adsorbent quantity on removal efficiency were examined with optimal conditions achieving 93.83% MB removal. The synthesised Y zeolite underwent characterisation utilising diverse techniques, including SEM, TEM, XRD, BET, and FTIR, which elucidated the structural and …


Post-Stroke Lateropulsion In Australia And New Zealand: A Survey Investigating Current Knowledge, Priorities And Practice, Jessica Nolan, Angela Jacques, Barbara Singer Jan 2025

Post-Stroke Lateropulsion In Australia And New Zealand: A Survey Investigating Current Knowledge, Priorities And Practice, Jessica Nolan, Angela Jacques, Barbara Singer

Research outputs 2022 to 2026

Background: Post-stroke lateropulsion is prevalent and associated with poor rehabilitation outcomes, but evidence to guide rehabilitation of affected stroke survivors is limited. Current post-stroke lateropulsion rehabilitation practice across Australia and New Zealand has not been previously described. Objectives: This study aimed to describe lateropulsion rehabilitation practice in Australia and New Zealand, determine clinicians,’ educators’ and researchers’ opinions about the need for educational resources to guide best-practice, and to identify current barriers to, and enablers of, optimal rehabilitation delivery. Methods: This cross-sectional survey was distributed to stroke rehabilitation clinicians, educators and researchers across Australia and New Zealand using Qualtrics. Data were …


Adaptive Crisis Management At The Operational Level: Responses To Covid-19 In The Australian Resources Sector, Michael M. Ajith, Andrei A. Lux, Tim Bentley, Michelle Striepe Jan 2025

Adaptive Crisis Management At The Operational Level: Responses To Covid-19 In The Australian Resources Sector, Michael M. Ajith, Andrei A. Lux, Tim Bentley, Michelle Striepe

Research outputs 2022 to 2026

The COVID-19 pandemic in 2020 significantly impacted Australia’s resources sector, particularly mining, oil, and gas industries, posing challenges for operational leaders. This study applied Adaptive Crisis Management Theory (ACMT) to understand how these leaders adapted during the crisis. Through interviews with 32 operational leaders, it was found that their roles evolved as crisis demands changed. Initially, they addressed immediate needs, then shifted focus to remote work facilitation and digital transformation, and finally emphasised recovery, trust, and resilience. These adaptations influenced leaders’ behaviours, highlighting the importance of flexibility in supporting employee wellbeing and organisational continuity during crises.


Analysing The Behaviour Change Techniques In An Effective Food Literacy Program To Inform Future Program Design, Lucy M. Butcher, Caylah Batt, Sophie Royce, Eamon Barron, Roslyn Giglia, Andrea Begley Jan 2025

Analysing The Behaviour Change Techniques In An Effective Food Literacy Program To Inform Future Program Design, Lucy M. Butcher, Caylah Batt, Sophie Royce, Eamon Barron, Roslyn Giglia, Andrea Begley

Research outputs 2022 to 2026

Aim: Food literacy programs aim to improve food related skills and knowledge and are selected Governments as a strategy to address dietary intakes at a community level. The purpose of this research is to identify behaviour change techniques in a food literacy program, which were assessed by the achievement of participant goals related to food literacy and dietary behaviour changes. Methods: Consensus methods were applied to map behaviour change techniques to an adult food literacy program. A second phase investigation applied content analysis of participant process evaluation data (collected between 2016 and June 2021) to align target behaviours and behaviour …


Clinical Is The Pinnacle: Nurse Academics' Perspectives And Opinions Of Their Students Undertaking Mental Health Clinical Placements, Lorna Moxham, Kim Foster, Brenda Happell, Richard Lakeman, Michael Hazelton, John Hurley Jan 2025

Clinical Is The Pinnacle: Nurse Academics' Perspectives And Opinions Of Their Students Undertaking Mental Health Clinical Placements, Lorna Moxham, Kim Foster, Brenda Happell, Richard Lakeman, Michael Hazelton, John Hurley

Research outputs 2022 to 2026

Clinical placements form an integral and important part of preregistration nursing student learning. The theory–practice gap has been identified as problematic, with clinical experience being a key strategy to address this. Despite this, the perceptions of nurse academics teaching preregistration mental health nursing regarding clinical placements have not been widely explored. To garner perspectives and experiences of mental health clinical placements from nurse academics teaching mental health nursing to preregistration nursing students. A descriptive qualitative study involving 19 nurse academics from 13 metropolitan and regional Australian universities, who were involved in the design and delivery of preregistration mental health nursing …


Impact Of Rurality On Health Care Utilization Among Australian Residents From 2009 To 2021, Engida Yisma, Martin Jones, Lee San Pauh, Sandra Walsh, Sara Jones, Esther May, Marianne Gillam Jan 2025

Impact Of Rurality On Health Care Utilization Among Australian Residents From 2009 To 2021, Engida Yisma, Martin Jones, Lee San Pauh, Sandra Walsh, Sara Jones, Esther May, Marianne Gillam

Research outputs 2022 to 2026

Purpose: In Australia, there is limited research regarding the effect of rurality on health care utilization using longitudinal data.

Methods: We analyzed data from four annual waves (2009, 2013, 2017, and 2021) of the longitudinal Household, Income and Labour Dynamics in Australia (HILDA) Survey to examine changes in the health care utilization over time among urban and rural residents. Poisson regression models estimated adjusted incidence rate ratios (aIRR) and 95% confidence intervals (CIs) for rural versus urban residents, accounting for a range of health-related and sociodemographic characteristics. Health care utilization was measured using four key indicators: visits to family doctor …


Managing The Impact Of Workplace Trauma For Australian First Responders: Harmonizing Policy And Practice, Aglae Hernandez Grande, Fleur Sharafizad, Ben Farr-Wharton, Yvonne Brunetto, Matthew Richman Jan 2025

Managing The Impact Of Workplace Trauma For Australian First Responders: Harmonizing Policy And Practice, Aglae Hernandez Grande, Fleur Sharafizad, Ben Farr-Wharton, Yvonne Brunetto, Matthew Richman

Research outputs 2022 to 2026

Police, fire, ambulance, and emergency services workers face an increased exposure to traumatic events while at work, negatively affecting their mental health, and with broader financial, legal, and moral implications for the public sector organizations that employ them. To better support these workers, and to mitigate the potential financial burden resulting from workers’ compensation claims, many first responder organizations are implementing wellbeing initiatives. This article examines the efficacy of an initiative for a sample of 530 frontline and administrative first responders, working in one state jurisdiction in Australia. The results indicate that wellbeing programmes moderate the impact of trauma on …


Neurodivergent (Autism And Adhd) Student Experiences Of Access And Inclusion In Higher Education: An Ecological Systems Theory Perspective, Luke Butcher, Stevie Lane Jan 2025

Neurodivergent (Autism And Adhd) Student Experiences Of Access And Inclusion In Higher Education: An Ecological Systems Theory Perspective, Luke Butcher, Stevie Lane

Research outputs 2022 to 2026

Higher Education (HE) can be a complicated and isolating experience for neurodivergent students. Many systemic barriers and injustices create challenges for the accessibility and inclusivity of learning environments and curriculums. However, with the appropriate accommodations, staff guided by neurodiversity-affirming practices, accessible curricula, and opportunities to connect with neurodivergent peers, it can be highly rewarding. Through 15 in-depth, lived-experience-informed interviews with neurodivergent HE students who are Autistic and/or ADHDers in Australia, we analyse experiences at different system levels. By validating the robust framework of ecological systems theory in this context, we extend the academic understanding and add to the limited research …


Neuromuscular Characteristics Of Eccentric, Concentric And Isometric Contractions Of The Knee Extensors, Cassio V. Ruas, Janet L. Taylor, Christopher Latella, G. Gregory Haff, Kazunori Nosaka Jan 2025

Neuromuscular Characteristics Of Eccentric, Concentric And Isometric Contractions Of The Knee Extensors, Cassio V. Ruas, Janet L. Taylor, Christopher Latella, G. Gregory Haff, Kazunori Nosaka

Research outputs 2022 to 2026

Purpose: We compared voluntary drive and corticospinal responses during eccentric (ECC), isometric (ISOM) and concentric (CON) muscle contractions to shed light on neurophysiological mechanisms underpinning the lower voluntary drive in a greater force production in ECC than other contractions.

Methods: Sixteen participants (20–33 years) performed ISOM and isokinetic (30°/s) CON and ECC knee extensor contractions (110°–40° knee flexion) in which electromyographic activity (EMG) was recorded from vastus lateralis. Voluntary activation (VA) was measured during ISOM, CON and ECC maximal voluntary contractions (MVCs). Transcranial magnetic stimulation elicited motor-evoked potentials (MEPs) and corticospinal silent periods (CSP) during MVCs and submaximal (30%) contractions, …


People With Hip Osteoarthritis Have Reduced Quadriceps Voluntary Activation And Altered Motor Cortex Function, Myles C. Murphy, Molly Coventry, Janet L. Taylor, Ebonie K. Rio, Andrea B. Mosler, Jackie L. Whittaker, Christopher Latella Jan 2025

People With Hip Osteoarthritis Have Reduced Quadriceps Voluntary Activation And Altered Motor Cortex Function, Myles C. Murphy, Molly Coventry, Janet L. Taylor, Ebonie K. Rio, Andrea B. Mosler, Jackie L. Whittaker, Christopher Latella

Research outputs 2022 to 2026

Aims: Compare quadriceps voluntary activation, corticospinal and intracortical excitability between people with and without hip osteoarthritis (OA). Exploratory objectives include quantifying the association of corticospinal/intracortical excitability with voluntary activation, corticospinal/intracortical excitability with hip related pain, and motor threshold with motor cortex inhibition and facilitation. Methods: Case-control study including participants with clinically and radiologically confirmed hip OA and non-OA controls. Quadriceps voluntary activation was assessed using twitch interpolation via femoral nerve stimulation. Single- and paired-pulse transcranial magnetic stimulation over the motor cortex assessed resting motor threshold (RMT), active motor threshold (AMT), short-interval intracortical inhibition (SICI), intracortical facilitation (ICF) and silent period. …


Tourette Syndrome Research Highlights From 2024 [Version 3; Peer Review: 2 Approved, 1 Approved With Reservations], Andreas Hartmann, Per Andrén, Cyril Atkinson-Clement, Virginie Czernecki, Cécile Delorme, Simon Morand-Beaulieu, Nanette Mol Debes, Kirsten Müller-Vahl, Peristera Paschou, Natalia Szejko, Apostolia Topaloudi, Kevin J Black Jan 2025

Tourette Syndrome Research Highlights From 2024 [Version 3; Peer Review: 2 Approved, 1 Approved With Reservations], Andreas Hartmann, Per Andrén, Cyril Atkinson-Clement, Virginie Czernecki, Cécile Delorme, Simon Morand-Beaulieu, Nanette Mol Debes, Kirsten Müller-Vahl, Peristera Paschou, Natalia Szejko, Apostolia Topaloudi, Kevin J Black

2020-Current year OA Pubs

We summarize research reports from 2024 relevant to Tourette syndrome, which the authors consider the most important or interesting. This working draft aims to submit this content for publication around the beginning of 2025 in the yearly Tourette Syndrome Research Highlights series on F1000Research. The authors welcome article suggestions and thoughtful feedback from readers, who can add a comment by clicking on the rectangular comment box icon to the left of the LOG IN link at the top of this page. For private comments, you can reach us by email ( [email protected] or [email protected]).


Ephemeral Seagrass Meadow Assessment To Improve Understanding Of Resilience Of Ephemeral Seagrasses On Kwinana Shelf For Environmental Impact Assessment And Management, Kathryn Mcmahon, Nicole Said, Chanelle Webster, H. Williams, Simone Strydom Jan 2025

Ephemeral Seagrass Meadow Assessment To Improve Understanding Of Resilience Of Ephemeral Seagrasses On Kwinana Shelf For Environmental Impact Assessment And Management, Kathryn Mcmahon, Nicole Said, Chanelle Webster, H. Williams, Simone Strydom

Research outputs 2022 to 2026

Executive Summary:

• This study was conducted to generate knowledge to inform the environmental impact and prediction process for seagrass species that form ephemeral meadows in Cockburn Sound and Owen Anchorage.

• Local light thresholds for the opportunistic species, Syringodium isoetifolium were generated at summer and winter temperatures, with higher light requirements in summer compared to winter, and compared to larger, more slow-growing persistent species such as Posidonia sinuosa. The half-saturating irradiance (Ik) was 115 μmol m-2 s-1 at 23 °C.

• Based on the dynamics at three sites from December 2023 to April 2024, Halophila ovalis forms ephemeral meadows …


Effects Of Obesity On Plasma Biomarker And Amyloid Pet Trajectories In Alzheimer's Disease, Soheil Mohammadi, Farzaneh Rahmani, Mahsa Dolatshahi, Suzanne E Schindler, Cyrus A Raji, Adni Collaborators Jan 2025

Effects Of Obesity On Plasma Biomarker And Amyloid Pet Trajectories In Alzheimer's Disease, Soheil Mohammadi, Farzaneh Rahmani, Mahsa Dolatshahi, Suzanne E Schindler, Cyrus A Raji, Adni Collaborators

2020-Current year OA Pubs

INTRODUCTION: Obesity is a risk factor for Alzheimer's disease (AD), but its impact on AD blood biomarker (BBM) and amyloid positron emission tomography (PET) trajectories is unknown.

METHODS: One thousand two hundred twenty-eight plasma samples from the Alzheimer's Disease Neuroimaging Initiative (ADNI) were assessed using six leading commercial tests (C2N, Fujirebio, Janssen, ALZpath, Roche, and Quanterix). Amyloid PET scans were used to assess amyloid burden in Centiloids (CLs). Spearman partial correlations assessed cross-sectional associations, while linear mixed-effects models examined the longitudinal impact of obesity status on BBMs and CLs.

RESULTS: Higher body mass index at baseline was correlated with lower …


Assessing The Clinical Meaningfulness Of Slowing Cdr-Sb Progression With Disease-Modifying Therapies For Alzheimer's Disease, Sarah M Hartz, Suzanne E Schindler, Marissa L Streitz, Krista L Moulder, Jessica Mozersky, Guoqiao Wang, Chengjie Xiong, John C Morris Jan 2025

Assessing The Clinical Meaningfulness Of Slowing Cdr-Sb Progression With Disease-Modifying Therapies For Alzheimer's Disease, Sarah M Hartz, Suzanne E Schindler, Marissa L Streitz, Krista L Moulder, Jessica Mozersky, Guoqiao Wang, Chengjie Xiong, John C Morris

2020-Current year OA Pubs

INTRODUCTION: For many patients and caregivers, a major goal of disease-modifying treatments (DMTs) for Alzheimer's disease (AD) dementia is to extend independence in instrumental and basic activities of daily living (IADLs and BADLs). The goal of this study was to estimate the effect of treatments on the time remaining independent in IADLs and BADLs.

METHODS: Participants at the Knight Alzheimer Disease Research Center (Knight ADRC) who met eligibility criteria for recent DMT trials were studied: age ≥60 years at baseline, clinical diagnosis of very mild or mild AD dementia (global Clinical Dementia Rating [CDR] score 0.5 or 1), biomarker confirmation …


Acute Metabolic Decompensation After Liver Transplant In A Patient With Maple Syrup Urine Disease, Shao Ching Tu, Marium Khan, Katie Wolfe, Sakil S Kulkarni, Elizabeth Toolan, Dorothy K Grange Jan 2025

Acute Metabolic Decompensation After Liver Transplant In A Patient With Maple Syrup Urine Disease, Shao Ching Tu, Marium Khan, Katie Wolfe, Sakil S Kulkarni, Elizabeth Toolan, Dorothy K Grange

2020-Current year OA Pubs

Maple syrup urine disease (MSUD) is an inborn error of metabolism characterized by the accumulation of branched-chain amino acids (leucine, isoleucine, and valine) caused by a defect in the branched-chain alpha-keto acid dehydrogenase complex. Liver transplant is an effective therapy for MSUD, and patients can usually tolerate a regular diet after transplant without symptomatic metabolic decompensation. Most post-transplant patients do not follow a sick-day diet. We report a case of a 7-year-old male with MSUD Type IA, status post-liver transplant at 2 years of age, who presented with profound encephalopathy following poor oral intake and vomiting for 3 days. Broad …


Schistosomiasis Interventions In Africa: Assessment And Systematic Review, Christopher Yaw Dumevi, George Boateng Kyei, Patience B Tetteh-Quarcoo, James-Paul Kretchy, Irene Ayi, Patrick F Ayeh-Kumi Jan 2025

Schistosomiasis Interventions In Africa: Assessment And Systematic Review, Christopher Yaw Dumevi, George Boateng Kyei, Patience B Tetteh-Quarcoo, James-Paul Kretchy, Irene Ayi, Patrick F Ayeh-Kumi

2020-Current year OA Pubs

No abstract provided.


Clinical And Neuropathological Associations Of Plasma Aβ42/Aβ40, P-Tau217 And Neurofilament Light In Sporadic Frontotemporal Dementia Spectrum Disorders, Binita Rajbanshi, Randall J Bateman, Et Al. Jan 2025

Clinical And Neuropathological Associations Of Plasma Aβ42/Aβ40, P-Tau217 And Neurofilament Light In Sporadic Frontotemporal Dementia Spectrum Disorders, Binita Rajbanshi, Randall J Bateman, Et Al.

2020-Current year OA Pubs

INTRODUCTION: Plasma amyloid beta

METHODS: We compared the clinical, neuroimaging, and neuropathological associations of plasma Aβ

RESULTS: Aβ

DISCUSSION: Plasma p-tau217 has clinical, neuroimaging, and neuropathological correlates in sporadic FTD and may identify FTD cases with AD co-pathology.

HIGHLIGHTS: Alzheimer's disease (AD) features could be identified with plasma phosphorylated tau217 (p-tau217) in frontotemporal lobar degeneration (FTLD).Plasma p-tau217 is a better discriminator of AD co-pathology and AD-associated features in FTLD than plasma amyloid beta


Qualitative And Quantitative Analysis Of A Novel Dental Health Education Program To Improve Dental Care Utilization By Bhutanese-, Burmese-, And Swahili-Speaking Refugees In A Midwestern United States City, Chandra Swanson, Katherine Gordon, Kelly Kreisler, Elizabeth Montgomery Collins Jan 2025

Qualitative And Quantitative Analysis Of A Novel Dental Health Education Program To Improve Dental Care Utilization By Bhutanese-, Burmese-, And Swahili-Speaking Refugees In A Midwestern United States City, Chandra Swanson, Katherine Gordon, Kelly Kreisler, Elizabeth Montgomery Collins

2020-Current year OA Pubs

No abstract provided.


Plasma Nfl And Cognitive Functioning In Older Adults: The Moderating Role Of Hdl Cholesterol, Ramkrishna K Singh, Semere Bekena, Yiqi Zhu, Carlos Cruchaga, Steven E Arnold, Beau M Ances, Ganesh M Babulal Jan 2025

Plasma Nfl And Cognitive Functioning In Older Adults: The Moderating Role Of Hdl Cholesterol, Ramkrishna K Singh, Semere Bekena, Yiqi Zhu, Carlos Cruchaga, Steven E Arnold, Beau M Ances, Ganesh M Babulal

2020-Current year OA Pubs

BACKGROUND AND OBJECTIVES: Plasma neurofilament light chain (NfL) is a marker of neuroaxonal injury associated with cognitive decline. High-density lipoprotein (HDL) cholesterol has neuroprotective properties, but its interaction with neurodegeneration remains unclear. This study examined whether HDL moderates the association between NfL and cognitive performance.

METHODS: Baseline data from 417 participants in the Aging Adult Brain Connectome study were analyzed. Plasma NfL and HDL were measured via Simoa and enzymatic assays; cognition was assessed using Montreal Cognitive Assessment (MoCA) and Preclinical Alzheimer Cognitive Composite (PACC). Generalized linear models were used to evaluate NfL and HDL interactions, adjusting for demographics. Sensitivity …