Digital Commons Network^™

Construction And Optimization Of An Efficient Tyrosol Biosynthesis System In Escherichia Coli, Yizhe Xiong, Shougang Wang, Zhiming Rao, Meijuan Xu

Journal of Food Science and Biotechnology

[Objective ] An efficient biosynthetic system was constructed in Escherichia coli to achieve high-yield production of tyramine and its key derivative tyrosol.[Method ] Through the analysis of protein expression,enzymatic properties,and whole-cell catalysis results,tyrosine decarboxylase (TDC ) derived from Enterococcus faecalis was selected as the key enzyme for tyramine synthesis.Subsequently,tyramine oxidase (TYO ) was introduced to construct the TDC-TYO pathway for tyrosol production.Meanwhile,the LAAD-PDC pathway for tyrosol synthesis was established.A dual-enzyme co-expression system was established,and the effects of tandem enzyme order,production pathways,and key enzyme sources on tyrosol yield were analyzed.The recombinant strain B 1,carrying the plasmid pET 28a-EfTDC-TYO,was obtained through whole-cell …

Promoting The Synthesis Of Salicylic Acid In Escherichia Coli Based On Metabolic Engineering And Multi-Enzyme Cascade Strategy, Kai Wang, Xuewei Pan, Taowei Yang, Zhiming Rao

Journal of Food Science and Biotechnology

[Objective ] The production of the aromatic compound salicylic acid (SA) is limited by its inhibitory effects on enzymes related to cellular energy metabolism.This study aims to develop a strategy for avoiding the impact of SA on enzymes related to cellular energy metabolism and increase the yield of SA.[Method ] A highly efficient Escherichia coli strain was designed to improve SA production by optimizing metabolic pathways and enzyme systems.[Result ] The genome-scale metabolic model GEMS 1515 was employed to predict the key bottle necks in the phosphoenolpyruvic acid (PEP) pathway and SA biosynthesis pathways.The SA yield was successfully increased from …

Fermentation Technology Of L-Lysine Production By Immobilized Corynebacterium Glutamicum, Qingguo Liu, Hanjie Ying, Wenjun Sun

Journal of Food Science and Biotechnology

[Objective ] This study aimed to investigate the feasibility of the fermentation process for L-lysine production by immobilized Corynebacterium glutamicum.[Method ] Firstly,the effects of different volume fractions of seed medium on the fermentation stability of immobilized Corynebacterium glutamicum were examined.Subsequently,the impacts of immobilization carriers with different specifications on the fermentation performance were analyzed.Finally,a comparative analysis was conducted on the differences between the fermentation processes with free and immobilized Corynebacterium glutamicum.[Result ] The addition of 5% volume fraction of seed medium adequately sustained the growth and metabolic activities of Corynebacterium glutamicum.Higher volume fractions diverted carbon sources towards bacterial growth,thereby limiting product …

Reduction Of Methanol Content By Protoplast Fusion In Fruit Wine Yeast, Huixiang Zhang, Nan Lin, Jiaru Wu, Xin Cheng, Weiwu Liang, Shijun Yang

Journal of Food Science and Biotechnology

[Objective ] This study aims to breed a fruit wine yeast strain with low methanol production by protoplast fusion.[Method ] With yeast strains LAB and XR as parents,protoplast fusion was employed to breed the yeast strains for fruit wine fermentation with a low mass concentration methanol and a high volume fraction ethanol.The process of yeast protoplast preparation was optimized by single factor and orthogonal experiments with the formation rate,regeneration rate,and preparation rate of protoplasts as indicators.The parental protoplasts were inactivated by ultraviolet radiation and heating,and 35 g/dL PEG- 6000 was used for chemical fusion after inactivation.[Result ] The optimum conditions …

Effects Of Metschnikowia Pulcherrima And 24-Epibrassinolide On Postharvest Preservation Of Grapes, Jiayan Qu, Huiping Niu, Bowen Li, Xiao Wang, Lujun Wang, Zhumei Xi, Xuefei Wang

Journal of Food Science and Biotechnology

[Objective ] This study aims to investigate the effects of different treatments on the postharvest preservation of grapes.[Method ] The impacts of 0.4 mg/L 24-epibrassinolide (EBR ),1×109 CFU/mL Metschnikowia pulcherrima,and their combination (YBR ) on postharvest storage of ‘Shine Muscat ’ grapes were evaluated.[Result ] Compared with the control (CK) group,EBR,Metschnikowia pulcherrima,and YBR treatments effectively reduced the water loss rate,maintained the firmness,and delayed the declines in protopectin and stem chlorophyll content of grape.In the later storage stage,YBR treatment delayed the decrease in flavonoid mass fraction,which was 12.95% higher than that of CK group.At the same time,YBR treatment reduced the mass …

Effects Of Single And Mixed Fermentation On Flavor , Composition , And Antioxidant Activity Of Soybean Whey, Taotao Wei, Qian Chen, Xiangjie Tao, Bin Tang, Fusheng Ren, Ping Hu

Journal of Food Science and Biotechnology

[Objective ] This study aims to explore the impacts of single strain fermentation and mixed fermentation on the flavor,composition,and antioxidant activity of soybean whey.[Method ] Gas chromatography-ion mobility spectrometry (GC-IMS ) was coupled with E-nose and high-performance liquid chromatography (HPLC ) to a nalyze the flavor and function of soybean whey fermented by the single and mixed strains.[Result ] Compared with single-strain fermentation by Limosilactobacillus fermentum HJS- 1 or Kluyveromyces marxianus HJS- 2,mixed fermentation (Limosilactobacillus fermentum HJS- 1 + Kluyveromyces marxianus HJS- 2) effectively improved the levels of functional substances and antioxidant activity of soybean whey.Compared with non-fermented soybean whey,mixed …

Efficient Catalytic Synthesis Of 5-Methylpyrazine- 2-Carboxylic Acid By Recombinant Escherichia Coli, Luxi Gan, Heng Gong

Journal of Food Science and Biotechnology

[Objective ] This study aimed to improve the yield and conversion rate of 5-methylpyrazine- 2-carboxylic acid (MPCA ) through biocatalysis.[Method ] Escherichia coli (E.coli）was used as the model organism to construct an MPCA synthesis system,and the whole-cell catalytic reaction conditions of recombinant E.coli were optimized.In addition,the parental host strain was subjected to ultraviolet mutagenesis for the screening of host strains tolerant to high mass concentrations of 2,5-dimethylpyrazine (DMP ).[Result ] The recombinant mutagenized strain could completely convert 10 g/L DMP to MPCA within 12 h in a 10 mL reaction system,achieving a yield of 12.9 g/L and a corresponding molar …

Goat Milk Formula Powder Ameliorates Lipopolysaccharide-Induced Intestinal Inflammation, Yi Shan, Xiaoling Liu, Shumei Wang

Journal of Food Science and Biotechnology

[Objective ] This study aimed to investigate the effects of goat milk formula powder on lipopolysaccharide (LPS)-induced intestinal inflammation and barrier impairment in mice.[Method ] Histopathological observation,real-time quantitative PCR,and enzyme-linked immunosorbent assay were used to assess changes in intestinal inflammation levels and barrier function-related indicators in mice following intervention with goat milk formula powder.Additionally,the composition of the gut microbiota was analyzed to elucidate its potential mechanisms of action.[Result ] Goat milk formula powder alleviated intestinal histopathology and increased the number of goblet cells.Compared with the model group,the goat milk formula powder intervention reduced the mass fractions of pro-inflammatory cytokines TNF- …

Information Management / Bim Adoption And Implementation Roadmap, Robert Moore

Tools

This roadmap sets out a clear, practical approach for organisations to adopt and implement Information Management and Building Information Modelling (IM/BIM) in line with ISO 19650 and the Capital Works Management Framework (CWMF). It provides a phased pathway from early capacity to advanced capability, showing how organisations can progressively build skills, processes, and digital workflows while meeting the requirements of the Irish BIM mandate. The roadmap aligns organisational change with project-level delivery, emphasising the foundations of people, process, and technology, and the importance of collaboration, governance, and continuous improvement. Overall, it supports organisations in moving from basic information management to …

Information Management / Bim Technology Deployment Plan, Robert Moore

Tools

This technology deployment plan sets out the practical steps required to implement and operationalise selected Information Management and BIM (BIM) technologies. It defines activities, responsibilities, sequencing, and dependencies to ensure systems are configured, tested, and adopted in a controlled and coordinated manner. The plan supports effective change management, training, and transition to business-as-usual use, reducing risk and disruption. Overall, it provides a clear, actionable framework for moving from technology selection to consistent, reliable use that supports standards-aligned Information Management / BIM delivery.

Information Management / Bim Adoption Plan, Robert Moore

Tools

This adoption plan translates the Information Management and BIM adoption strategy into a clear, actionable programme of work. It sets out the specific activities, responsibilities, and sequencing required to build capability across people, processes, and technology, supporting consistent implementation in line with ISO 19650 and organisational objectives. The plan enables progress to be managed, monitored, and reviewed over time, ensuring adoption is proportionate, achievable, and aligned with project and business needs. Overall, it provides a practical mechanism for moving from intent to delivery, embedding Information Management and BIM as standard practice within the organisation.

Uniclass Irish Bim Mandate Guide, Robert Moore

Tools

This guidance document provides practical direction on implementing Uniclass within Irish public sector projects to support the Capital Works Management Framework (CWMF) BIM mandate. It explains how Uniclass, used alongside ISO 19650, IFC, and ICMS, enables consistent classification of information across the asset lifecycle, supporting the creation of a reliable golden thread of data from design through to operation. The document sets out how Uniclass works in practice, clarifying roles and responsibilities, common challenges, and mitigation measures, and includes a worked examples to support consistent application. Overall, the guide positions Uniclass as a key enabler of structured information management, improved …

Information Management / Bim Public Sector Adoption Business Case, Robert Moore

Tools

This business case sets out the value of adopting Information Management and BIM in line with ISO 19650 and the Irish CWMF. It shows how a structured approach to managing information across the asset lifecycle can improve collaboration, reduce risk and rework, and deliver measurable returns on investment. Evidence indicates that early adoption delivers the greatest benefit, supporting better cost control, compliance, and long-term asset performance. Overall, Information Management and BIM are positioned as essential enablers for efficient, sustainable, and future-ready delivery of public works

A Cross-Sectional Study On Patient Safety Attitudes And Their Determinants Among Medical Staff In Malaysian Public Specialist Hospitals, Sharifah Balqis Sayed Abdul Hamid, Aniza Ismail, Saperi Sulong

Makara Journal of Health Research

Introduction: This study aimed to assess the baseline level and mean scores of patient safety attitude domains among doctors and nurses in Malaysian public hospitals and to identify determinants associated with these attitudes across six domains: teamwork, safety climate, working conditions, job satisfaction, stress recognition, and perception of management.

Methods: A cross-sectional study was conducted using the Safety Attitudes Questionnaire (SAQ) among 142 doctors and 231 nurses from three public tertiary hospitals. Participants were selected through proportionate stratified random sampling. Data were analyzed using descriptive, bivariate, and multivariate methods.

Results: The study achieved an 81% response rate. …

Moving Toward Healthy Ageing: The Role Of Physical Activity In Cognitive Function And Self-Esteem Among Older Adults In Türkiye, Canan Birimoglu Okuyan, Müjde Kerkez

Makara Journal of Health Research

Background: This study aimed to evaluate the relationship between religious attitudes and breastfeeding attitudes and the effect of this relationship on breastfeeding practices.

Methods: A cross-sectional study was conducted with 251 older adults. Data were collected using the International Physical Activity Questionnaire, the Standardized Mini-Mental State Examination, and the Rosenberg Self-Esteem Scale. Spearman’s correlation and chi-square tests were employed for statistical analysis.

Results: Physical activity levels were positively correlated with both cognitive function (r = 0.546, p < 0.001) and self-esteem (r = 0.168, p < 0.05). No significant association was observed between cognitive function and self-esteem. Physical inactivity, cognitive decline, and low self-esteem were more prevalent among women, participants with lower educational attainment, those with chronic diseases, and individuals engaged in polypharmacy.

Conclusions: The findings emphasize the importance of integrating physical activity promotion into national healthy ageing policies, particularly in Mediterranean contexts such …

Analyzing Intellectual Alternatives To Student Academic Output ``A Specialized Study Of Academic Design Ideas And Alternatives'', Riyam Rajab Fanjan, Armin Sarkis Khosrof

Journal of King Abdulaziz University: Engineering Sciences

The design idea is the foundation on which the architectural design process. It is the basis for creating a distinguished architectural product that reflects the designer's thoughts, orientations, and way of thinking, whether within the black box or the glass box. Generating and selecting alternatives is one of the most important stages, followed by translating the alternative formally and functionally according to the design methodology followed by the designer and according to the design specifications represented by the type of project and its contextual constraints. In the context of architectural work, the research focuses on defining the design idea, the …

Schools Face High Cost Of Losing International Students, Eric F. Spina

President's Blog: From the Heart

UD President Eric F. Spina discusses how our campus, community and country benefit from welcoming international students — and by not welcoming them, we stand to lose a lot.

Information Management / Bim Adoption Strategy, Robert Moore

Tools

This adoption strategy sets out a structured approach for organisations to plan, govern, and deliver the adoption of Information Management and Building Information Modelling (IM/BIM). It focuses on aligning leadership intent with clear objectives, defined actions, and measurable outcomes, ensuring that people, processes, and technology are developed in a coordinated way. The strategy supports a phased and proportionate approach to adoption, enabling organisations to build capability over time, respond to client and market requirements, and embed continuous improvement. Overall, it provides a clear framework for translating strategic intent into practical, repeatable actions that support consistent, standards-aligned delivery and long-term organisational …

Multi-Criteria Decision-Making For Bid Evaluation And Selection In Water Resource Management Projects, Abdulaziz Alkabaa, Salah Omar Ammari, Abdul Z. Hameed

Journal of King Abdulaziz University: Engineering Sciences

We propose an enhanced multi-criteria decision-making (MCDM) framework using the Analytic Hierarchy Process (AHP) tailored for bid evaluation in water resource management projects. This approach addresses the persistent challenges of transparency, inconsistency, and technical-financial weighting observed in competitive bidding systems. By incorporating structured criteria across qualitative and quantitative dimensions, our model offers a more systematic, equitable, and operationally robust alternative to traditional evaluation practices. Case study applications demonstrate the framework's ability to yield clear differentiation among bids, improve decision traceability, and support procurement efficiency. These findings offer practical implications for policymakers and project stakeholders seeking to modernize bidding practices within …

Leveraging Deep Learning Models To Predict The Impact Of Project Changes On Timelines, Costs, And Quality For Enhanced Project Management, Ahmed Alkhard

Journal of King Abdulaziz University: Engineering Sciences

Managing projects in the modern world seems to be growing in dimness as it incorporates risks from multiple advancements which cut across technology, interrelationships between regions and developing societal expectations. Typical project management systems do not have the necessary accuracy or flexibility to include the possible impact of change in key components, such as scope change, resource changes, and external factors changes on the end values of performance metrics such as time, cost and quality. Such constraints are overcome in this work by implementing Deep Learning models such as FNN, LSTM networks, Attention Mechanisms or Ensemble models as the predictive …

Technical And Economic Study For Applying Solar Energy Systems To Government Buildings, Saeed Alghamdi

Journal of King Abdulaziz University: Engineering Sciences

Abstract: This paper presents a comprehensive feasibility study for integrating solar energy systems into three government buildings in the Kingdom of Saudi Arabia and connecting them to the public electricity grid. The study evaluates the project's economic viability by analyzing three years of electricity consumption data from these buildings. This analysis highlights the potential cost savings and environmental benefits of adopting solar power. Key factors such as average solar energy production, site-specific geographical conditions, and seasonal variations in sunlight were considered. The study utilized PVsyst software to simulate and optimize the solar photovoltaic (PV) systems, determining the number of solar …

Design And Optimization Of A Geothermal Thermoelectric Generator System (Gteg) In Saudi Arabia, Hassan Fagehi

Journal of King Abdulaziz University: Engineering Sciences

The demand for renewable energy is growing rapidly, driven by climate change and the need for sustainable solutions. This study focuses on designing and optimizing a geothermal thermoelectric generator (GTEG) system in Saudi Arabia, leveraging the country's geothermal potential. The optimization process investigated key parameters such as substrate materials, thermoelectric leg length, and dimensionless thermal and electrical conductance. The results reveal that using AlN as a substrate material, combined with a reduced leg length of 0.1 mm, significantly enhances power output, achieving 8.5 W per module. Dimensionless analysis further identified optimal dimensionless thermal conductance (N_k = 0.291) and dimensionless …

Techno-Economic Feasibility Study Of Rooftop Photovoltaic System For Soba Industrial Area, Khartoum State, Sudan, Ibrahim Ahmed Ibrahim Ali

Journal of King Abdulaziz University: Engineering Sciences

This study presents a detailed techno-economic assessment of a rooftop grid-connected photovoltaic system for Soba Industrial Area in Khartoum State, Sudan. Utilizing advanced modeling tools, namely the System Advisor Model and RETScreen Expert, critical technical parameters such as capacity factor, yield factor, and performance ratio, alongside key economic indicators including levelized cost of energy, payback period, and net present value are evaluated. The investigation also explores optimal panel orientation and conducts a sensitivity analysis of a two-axis tracking system, revealing its' potential for enhanced energy production. Findings indicate that the optimal tilt angle for the photovoltaic systems is 19 degrees, …

2d-Nanosilicate Carriers For Sustained Delivery Of Vaccine Components, Chih Yun Liu

McKelvey School of Engineering Graduate Student Theses & Dissertations

Laponite® 2D Nanosilicates (NS) are disc-shaped platelets (~30 nm diameter, ~1 nm thick) with positively charged edges and negatively charged faces, capable of loading proteins, drugs, and nucleic acids via electrostatic interactions to form a house-of-cards gel that sequesters cargo. Here, we evaluated NS for sustained delivery of antigens and Toll-like receptor (TLR) agonists to extend germinal center duration and enhance antibody quality. The model antigen ovalbumin (OVA) was adsorbed onto NS at acidic pH in a ~1:1 ratio, with partial unfolding that remained stable at physiological pH. NS-OVA complexes were efficiently internalized by dendritic cells, with uptake driven primarily …

A Shareholder Primacy Mindset In The Benefit Corporation’S Top Management Team And Greenwashing Actions, Jonathan Wimberly

Walden Dissertations and Doctoral Studies

Benefit corporations exist to benefit society and generate profit for shareholders and stakeholders, but there is evidence that greenwashing is prevalent among these entities. Business leaders need to understand the extent to which a shareholder primacy mindset influences the collective top management team and drives greenwashing in benefit corporations. The purpose of this quantitative correlational study was to determine the relationship between the collective demographic characteristics of top management teams and a shareholder primacy mindset, and to assess the relationship between a shareholder primacy mindset in the top management team of a benefit corporation and greenwashing behavior. Upper echelons theory …

Windkessel Parameter Estimation For Cardiovascular Feature Identification In Photoplethysmography Data, Calvin Boyce

Undergraduate Honors Theses

Features of cardiovascular health such as blood pressure, cardiac output, arterial compliance, and blood viscosity are important in evaluating heart health and disease risk, but are currently largely measured invasively and therefore only in critical settings. Here we explore the potential for Windkessel models to extract cardiovascular features from photoplethysmography (PPG) data in an attempt to evaluate heart health non-invasively. We show the capacity of a constrained Newton's method optimization scheme to estimate parameters and explore the tractability of the resulting parameters. While Newton's method is able to produce parameters that closely approximate PPG data, we found that using a …

Editorial Staff - The Crown, Vol. 2, The Crown

The Crown: Syracuse Honors Research Journal

No abstract provided.

Platforms, Privacy, And Power: Examining Predictors Of Online Intimate Information Disclosure And Expression, Alexis Shore Ingber, Danielle Keats Citron, Jonathon W. Penney

Articles & Book Chapters

When intimate privacy is violated, self- and relational development is impaired to the detriment of individuals and society. Despite these costs, there is a lack of systematic empirical and theoretical study of intimate privacy and efforts to protect it. This research helps fill this void through two complementary studies. Through a longitudinal experimental design, results from Study 1 highlight that partner trust and response-efficacy were not only positively predictive of online intimate disclosure, but also strengthened following knowledge of intimate privacy protections. In Study 2, we find individuals are more likely to engage in public-facing online sexual expression if the …

Faculty Senate Executive Committee Minutes December 15, 2025, Utah State University

Faculty Senate & Faculty Senate Executive Committee

• Call to Order
• University Business
• Faculty Senate Business
• Information
• Reports
• Council on Teacher Education
• Scholarship Annual Report
• University Studies Report
• Old Business
• New Business
• Adjourn 4:33

Rab32c Mediates Osmoregulation And Calcium Homeoastasis In Dictyostelium Discoideum, Ashley Esparza

Theses and Dissertations

Vesicular trafficking is a fundamental process essential to cell viability and dictates roles in both cellular and tissue function in multicellular organisms. To further understand various vesicular trafficking processes, our lab focuses on the moderators of these processes, Rab GTPases, using the model organism Dictyostelium discoideum. This dissertation focuses explicitly on the uncharacterized protein Rab32C, a homolog of human Rab32. While several Rab family members have been well defined, the functionality of Rab32C remains poorly understood. This project investigated both the subcellular localization and functional role of Rab32C with biochemical, imaging, and molecular assays. Results from this study provide evidence …