Polyphenols For The Mitigation Of Vascular Calcification; In Vitro And In Vivo Studies, Abdullah Altuhami

All Theses

Globally, cardiovascular diseases, in most cases associated with calcification, are the main cause of death. However, currently, the only effective cure is to undergo surgery to augment or receive a healthy donor heart, which could be very difficult due to the long waiting list and the associated risks. The possibility of body rejection of the foreign organs is attributed to immunoreaction or the risk of infection, since the donor must be on immunosuppressant drugs that lower the body's immunity and facilitate the body's acceptance of the new organ as one of its own. Taking that into consideration, using tissue-engineered vascular …

Effect Of Cigarette Smoke Extract And Nutrient Deficiency On Energy Metabolism And Biosynthesis: An In Vitro Intervertebral Disc Explant Culture Study, Avery E. Madden

All Theses

Low back pain consistently ranks among the leading causes of disability worldwide, with degenerative changes in spinal intervertebral discs (IVDs) recognized as a key contributor. Degeneration arises from the disruption of mechanical and biological cues within the disc’s cartilaginous tissue, often exacerbated by aging or injury. In recent decades, cigarette smoking has also been identified as a significant risk factor, as IVD degeneration is more prevalent among individuals with a history of smoking. Smoke inhalation is thought to promote degeneration both directly, by exposing cells to water-soluble toxic chemicals in smoke; and indirectly, through nutrient deficiency resulting from vasoconstriction and …

Assessing Grafted Triploid Watermelon And Yellow Nutsedge Growth In Saline Agroecosystems, Joseph F. Bazzle

All Theses

In an effort to better understand how saltwater intrusion events will impact watermelon growers a field trial was conducted to study how saline irrigation water will impact weed growth and seedless watermelon productivity at a joint Clemson University and USDA ARS facility. Weed management has always been a hurdle in vegetable crop production systems, requiring extensive labor even in a conventional setup. For organic growers, often the only economical approach is a combination of mechanical weed control techniques, including plastic mulches, tarps, and hand weeding. For watermelon growers, plastic mulch remains the most effective form of organic weed control available. …

Il-17a Immune Signature Across Stratified Stages Of Type 2 Diabetes​, Brittney C. White, Antonio Hernandes Chaves-Neto, Peter Elvin, Javier La Fontaine, Eric L. Brown, Walid Fakhouri, Craig Hanis, Claudia Biguetti

School of Podiatric Medicine - Student Research

Purpose: This study investigated whether IL-17A, a pro-inflammatory cytokine associated with Th17 cell activity, reflects distinct stages of type 2 diabetes progression.

Methods: Forty-two obese individuals (average age: 60.4 ± 10.3 years; 55% male; BMI: 31.3 ± 4.9) from Starr County, Texas, were matched for gender and BMI and stratified into five metabolic groups based on fasting blood glucose, 2-hour oral glucose tolerance test, and HbA1c levels. Groups included diabetes-free, isolated impaired glucose tolerance, combined glucose impairment, diabetes without complications, and diabetes with lower extremity complications. IL-17A protein levels were quantified from buffy coat samples using ELISA. After excluding …

Microplastics And Other Plastic-Like Microdebris In Sediments From The Dart River And Estuary, Southwest England, Maia Killian, Andrew Turner

School of Geography, Earth and Environmental Sciences

Surficial sediment samples (n = 10) collected from a transect of a river-estuary (Dart) in southwest England have been analysed for geochemical characteristics, anthropogenic metals (Cr, Cu, Sn, Pb, Zn), and microplastics (∼50 μm–5 mm) and other microplastic-like debris. Results indicated the finest grains towards the lower river and upper estuary, a seaward increase in sedimentary Ca, and loss on ignition ranging from about 0.7 to 4 %. Anthropogenic metals were heterogeneously distributed throughout the catchment with maximum concentrations in the river or lower estuary. Microplastics were dominated by fibres, with concentrations ranging from 110 to 1800 kg−1 and composition …

2025 Annual Report Of The Nominating Committee, University Of Northern Iowa. Faculty Senate.

Documents - Faculty Senate

University Nominating Committee report including committee memberships, produced by the Faculty Senate of the University of Northern Iowa.

Large Scale Deletion And Rebalancing Within The K1c Kafirin Family In Sorghum, Tyler W. Ferris

Department of Agronomy and Horticulture: Dissertations, Theses, and Student Research

Sorghum bicolor (L.) Monech (sorghum) is cultivated as food for humans and livestock and is valued for its low input requirements. However, sorghum grain protein is deficient in the essential amino acid lysine and has poor protein digestibility because of the abundance of proline-rich kafirins that constitute >70% of proteins that form low-digestibility protein bodies. To reduce kafirin expression in the endosperm, and elicit wholesale proteome rebalancing to increase non-kafirin proteins, a single-guide RNA (sgRNA) Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR/Cas9) construct was previously used to target members of the highly-repetitive alpha-kafirin family, k1C in RTx430 sorghum. The …

Plant Nutrient Interactions In High-Yielding Soybean Environments, Victoria Inklman

Department of Agronomy and Horticulture: Dissertations, Theses, and Student Research

Plant nutrient demands and limitations are usually studied individually by nutrient. Here, we investigated how nitrogen (N) limitation in high-yielding soybean environments affects the uptake, removal, and residual of other plant macro- and micronutrients. The objective of this study was to quantify the uptake, removal, and residual levels of soybean macro- and micronutrients under N-limited conditions and to identify nutrient priorities for high-yielding soybean systems. Aboveground plant samples at physiological maturity were collected in 19 high-yielding soybean fields with N limitation across the state of Nebraska. Reference plots with ample N supply were included within each field to compare macro- …

Crop, Soil Nutrient, And Soil Health Responses Within Integrated Crop And Livestock Systems, Alyssa K. Hall

Department of Agronomy and Horticulture: Dissertations, Theses, and Student Research

We evaluated the influences of grazing livestock on crop production, soil nutrients, and soil health indicators of integrated crop livestock systems using three experiments during a seven-yr. period. Objectives were to (1) determine livestock grazing and cropping system effects on crop yield and soil properties across six yr. in corn-soybean (C-S) and wheat-corn-soybean (W-C-S) systems with and without periodic composted manure application, (2) explore seasonal variation in soil nutrient patterns over two yr., and (3) measure residual responses for corn grain yield plus soil health indicators in yr. seven following a six-yr. study. In experiment 1, neither livestock grazing ( …

Developing Targets To Control Multiple Pest Fly Species: Violet Polyester Targets Effectively Attract Tsetse (Diptera: Glossinidae), Stable Flies (Diptera: Muscidae), And House Flies (Diptera: Muscidae), Michael N. Okal, Sheillah J. Akinyi, Roger D. Santer

All Peer-Reviewed Publications

Tsetse (Glossina spp.), stable (Stomoxys spp.), and house flies (Musca domestica L.) impact humans and animals through bites and/or disease transmission. Tsetse are controlled using insecticide-coated fabric targets that are traditionally blue and/or black, but a violet polyester has now been engineered for greater attractiveness. Here, we investigate whether violet targets are also effective against stable and house flies. We sampled flies by electrocution at 1.0 (H) × 0.5 m (W) targets in Kenya, comparing catches at violet targets, and blue and black targets made from polyesters used in commercial traps and targets. Catches of female but not male Glossina …

The Shape Of Absence: Diaspora And Echoes Of Mother In Lucy, Zahra Ebrahimi

All Theses

This thesis examines the impact of the motherland and maternal figure in shaping Lucy’s character in exile and her journey of self-discovery in Jamaica Kincaid’s Lucy. It explores the role of the past in shaping Lucy’s present by focusing on colonialism and the influence of both the Antiguan and white maternal figures on her path toward independence and self-discovery. Throughout the narrative, Kincaid invites readers to follow the deep and complicated relationship between Lucy’s white mother, Mariah, and her mother in Antigua. These interactions shape Lucy’s character and encourage readers to view the story not just as the tale …

Effect Of Amino Acid Derivatives And Polyphenol Supplementation On Skeletal Muscle Growth In-Vitro And In-Vivo, Gabriella C. Iheanacho

All Theses

Background

Satellite cells (SCs) are myogenic precursor cells that play a crucial role in muscle growth, and their activity can be influenced by nutrient supplementation. Muscle growth can also be stimulated using growth-promoting hormones; however, there are no approved growth hormones for use in sheep in the United States (Qaid & Abdoun, 2022). This limitation highlights a need to identify alternative compounds that would serve as nutrient supplements to enhance muscle growth and thereby improve meat production. Amino acid derivatives such as guanidinoacetic acid (GAA) and 5-hydroxytryptophan (5-HTP), along with the polyphenol quercetin, are naturally derived compounds that have shown …

Post-Harvest Storage Of Fuzzy Cottonseed: Quality, Airflow Modeling, And Energy Use, Elijah T. Porter

All Theses

Fuzzy cottonseed is a valuable byproduct of the cotton ginning process. When cottonseed exits the cotton gin, it often retains high temperatures and moisture contents. Once in a storage facility, the cottonseed needs to be conditioned for safe storage. The overall objectives of this study were to analyze quality changes in cottonseed according to storage conditions, determine the airflow resistance properties of fuzzy cottonseed, develop a computational fluid dynamics (CFD) model of a representative cottonseed storage facility, and analyze cottonseed aeration fan strategies, runtimes, and costs. Changes in quality dictate the allowable storage time for cottonseed and are impacted by …

Computational Study Of Nonlinear Electrokinetic Phenomena In Shear-Thinning Fluids, Wai Yuen Leung

All Theses

Electrokinetic phenomena have been widely used for fluid pumping and particle manipulation in micro/nanofluidic systems. They refer to the motion of fluids or particles in response to an electric field because of the spontaneous formation of an electric double layer at the fluid-solid interface. Understanding electrokinetic phenomena in micro/nanochannels is critical for a wide range of applications across various engineering fields, such as disease diagnostics, contaminant treatment and cell analysis. To date, numerous studies have been reported on electrokinetic phenomena in Newtonian fluids, where the classical Helmholtz-Smoluchowski theory indicates a linear relationship between fluid electroosmosis/particle electrophoresis and electric field. However, …

Effectiveness Of Electrosynthesized Hydrogen Peroxide In Urease Inactivation For Stabilization Of Source-Separated Urine To Recover Urea, Brooke E. Covert

All Theses

The practice of separating urine at a building scale, rather than mixing with domestic wastewater to be treated at water resource recovery facilities, allows for concentrated urine to be directly treated with the aim of resource recovery. However, source separation and treatment present challenges during separation, storage, and transport. This study evaluated the use of hydrogen peroxide-producing electrochemical cells, which represent a technology that uses electricity as an input, to stabilize urine through cathodically produced peroxide to enable downstream water and nutrient recovery. The electrochemical cells have been previously shown to stabilize urine with electrochemically produced peroxide as an effective …

Association Between Gene Family Expansion And The Rapid Diversification Of Pleurocarpous Mosses, Meredith A. Cobb

All Theses

Mosses are the second most species-rich group of land plants. They represent a critical group for understanding the evolution and diversity of land plants. Mosses comprise two major groups, acrocarps and pleurocarps. Despite having a more recent evolutionary origin than acrocarps, pleurocarps are exceptionally diverse. The difference in species richness reflects a rapid species diversification, roughly coincident with the origin and diversification of flowering plants. The speciation events giving rise to pleurocarp diversity happened so rapidly, making it historically difficult to produce strongly supported phylogenies with which to test evolutionary hypotheses. One such hypothesis is whether large-scale changes at the …

Determining The Impact Of Surface Roughness On Disinfection Efficacy Of Commercial Products Against Pseudomonas Aeruginosa And Staphylococcus Aureus Wet Surface Biofilms, Kayley Stallings

All Theses

Biofilms are resistant to many stressors including disinfectant treatments. Disinfection may be further complicated by biofilms formed on damaged surfaces, as the damaged parts provide bacteria a better place to attach and grow. To better understand the risks, a new method to standardize surface scratching, to emulate worn surfaces via surface roughness changes was developed. These surfaces were used to grow biofilms with an adapted standardized EPA method to determine disinfection efficacy differences on scratched and non-scratched high-density polyethylene (HDPE) and stainless steel (SS) coupons treated with commercial disinfectants [hypochlorite (CL)-based, hydrogen peroxide (HP)-based, and quaternary ammonium (QA)-based]. Post-80 grit …

Mammal Use Of Crossing Structures On Highways In The Southern Blue Ridge Mountains, Chloe E. Horton

All Theses

Road networks are a major driver of habitat fragmentation and wildlife mortality. Wildlife crossing structures (WCS) are a common mitigation strategy with the goal of maintaining landscape connectivity, reducing wildlife-vehicle collisions, and facilitating safe passage across highways. Most research on WCS prioritize large ungulates or carnivores, leaving potential gaps in our understanding of how diverse mammalian communities interact with these features. We investigated spatial, temporal, and behavioral patterns of small-, medium-, and large-bodied mammals using WCS in the southern Blue Ridge Mountains of North Carolina and Tennessee. Using remote camera data from structures on I-40 and I-26 collected from 2018 …

Restoring A Longleaf Pine Savanna In The Wiregrass Gap: Community Responses To Post-Harvest Slash Manipulation, Eva Purcell

All Theses

Now reduced to just a fraction of their historical range, Longleaf pine savannas in the southeastern United States are home to a wide array of species, some of which are threatened or endemic. These characteristics have inspired widespread restoration initiatives in recent decades, accompanied by an expanding literature on how management techniques affect restoration outcomes. However, research is lacking in a unique region of longleaf pine’s range, where the dominant fire-carrying grasses are different: the Wiregrass Gap. This study investigated the effects of three different slash manipulation treatments on restoration outcomes of a Wiregrass Gap longleaf pine savanna. Specifically, we …

Expandable Tissue Engineered Living Pulmonary Heart Valve For Pediatric Patients, David Podolsky

All Theses

Cardiovascular disease is an extremely deadly disease that affects people throughout the world. It is the leading cause of death worldwide, affecting over a quarter of the population.1 Some forms of cardiovascular disease directly affect the heart valves and their function. Surgery or a replacement device are the most common current treatment options. These treatments are effective in addressing heart valve diseases in adults, but they are less effective when used for children patients. This creates a need to develop a solution for the child population.

Congenital heart defects are structural abnormalities that often lead to infant mortality.2,3 Pulmonary valves, …

Integrating Art Therapy And Emerging Technologies For Enhanced Neuroplasticity And Ptsd Intervention, Piper Hutson, James Hutson

Faculty Scholarship

Post-traumatic stress disorder (PTSD) remains resistant to many conventional treatments, underscoring the need for integrative approaches that harness neuroplasticity. Art therapy, with its capacity to facilitate nonverbal trauma processing and multisensory engagement, has shown distinctive advantages over verbal and pharmacological interventions. Recent innovations, including virtual reality (VR), artificial intelligence (AI), and biofeedback have amplified the therapeutic efficacy of art-based interventions by enabling adaptive, real-time modulation of emotional and physiological states. This review synthesizes current research on technologically enhanced art therapy, comparing it to established treatments such as cognitive behavioral therapy (CBT) and eye movement desensitization and reprocessing (EMDR). Findings indicate …

Evaluating The Impact Of Activated Carbon On The Biodegradation Of Btex Compounds, Megan Barkley

All Theses

BTEX compounds—benzene, toluene, ethylbenzene and xylenes—are toxic, volatile, aromatic hydrocarbons. They are primarily found in petroleum products and can easily enter the environment. Typical remediation techniques include sorption to activated carbon, pump and treat, and bioremediation. Research suggests that combining sorption to activated carbon and bioremediation may enhance BTEX removal. This study evaluates the impact of granular activated carbon (GAC) on the biodegradation of ethylbenzene and toluene, using an enrichment culture of aerobic bacteria.

The main objectives of this study are to grow and maintain a culture that degrades BTEX compounds, evaluate the effect of activated carbon on the biodegradation …

The Future Research Direction Of Cgiar: Lessons Learned From One Cgiar, Katie Loethen

Graduate Theses and Dissertations

Since its founding in 1971, CGIAR (formerly the Consultative Group on International Agricultural Research) has been at the forefront of agricultural innovation, credited with launching the Green Revolution and delivering 1.78 trillion USD in net present value (NPV) benefits globally, particularly in low- and middle-income countries. Despite these accomplishments, CGIAR now faces internal and external pressures that threaten its future impact. The 2019 reorganization into “One CGIAR” aimed to enhance coordination but has been criticized for adding bureaucracy and reducing scientific autonomy. Simultaneously, public funding for agricultural research is shrinking, while private sector investment often overlooks low-margin, high-need areas central …

Factors Influencing Cognitive Load: Exploring Affective Elements, Motivational Constructs, And Regulatory Strategies In Learning, Rebecca B. Brockbank

All Graduate Theses and Dissertations, Fall 2023 to Present

There are three separate research papers within this dissertation, each looking at specific elements of learning. The process of learning is a complex phenomenon that includes not just cognitive aspects, but also emotional and motivational aspects. During learning there is an input of information into our cognitive system (i.e., minds). When too much information is given or the information is not presented effectively, this can overload our cognitive system and negatively impact our learning. Understanding how to learn within the parameters of our cognitive system is important. However, learning is more complex than just the simple input and output of …

Tree Rings And The Broader Ocean-Atmospheric Circulation In The Highland Himalayas, Sanjaya Bhandari

All-Inclusive List of Electronic Theses and Dissertations

Climate change has altered tree-growth patterns and resulted in higher sea-surface temperatures across the planet. The Himalayan biome is one of the most vulnerable areas in the world to climate change because it has caused changes in forests’ growth and glaciers’ retreat. Dendrochronology has been used to understand the impact of climate change on tree growth and for climate reconstruction. In this dissertation, I discuss the growth of trees in the highlands of the eastern, central, and western Himalayas for the last 500 years and relate these patterns to the present global warming scenario and broad-scale climate modes. I reconstructed …

In Vitro Assessment Of The Antihistomonal Activity Of Methyl Jasmonate And Jasmonic Acid, Mckayla B. Williams

Poultry Science Undergraduate Honors Theses

Histomonas meleagridis is a protozoan parasite and the causative agent of histomonosis in gallinaceous birds. There are currently no approved prevention or treatment options available for histomonosis control in the United States. Mortality in affected turkey flocks can exceed 80% which highlights the urgent need for research investigating novel strategies to mitigate histomonosis in the field. The objective of this study was to evaluate the in vitro antihistomonal and antibacterial effects of of methyl jasmonate (MeJA) and jasmonic acid (JA), two plant-derived compounds, in a xenic culture of H. meleagridis. Assays were conducted using cultured H. meleagridis (PHL strain) treated …

Female Preference And Prezygotic Isolation In The Fundulus Notatus Species Complex, Emilee K. Holderness

Master's Theses

Understanding how reproductive isolation arises between closely related species is central to evolutionary research. Hybridization is widespread across taxa and shaped by interactions among environmental factors, evolutionary history, genetic compatibility, and behavior. These forces often operate nonlinearly across space and time, yet mate choice is frequently assessed under artificial conditions that may not reflect natural behavior. To address this limitation, female mate preference was investigated within the Fundulus notatus species complex, where F. notatus and F. olivaceus hybridize at varying rates across replicate contact zones. Using a free-choice design, behavioral trials were conducted with individuals from populations characterized by high …

Synthesis And Characterization Of Polymer-Coated Metal Nanostructures And Gelatin-Incorporated Hydrogels For Biomedical Use, Deborah Takyibea Okyere

Graduate Theses and Dissertations

The development of advanced materials for disease management and treatment presents a pressing challenge in the health sector. The overall objective of this research is to contribute to the development of advanced materials with tailored properties for biomedical applications, with a focus on cost-effective and robust nanoparticles and biomaterials. The first part of this work focuses on designing and synthesizing earth-abundant copper nanoparticles with desired optical properties. Copper nanoparticles, which provide a more affordable alternative to gold and silver, are being investigated due to their unique plasmonic properties. However, their susceptibility to oxidation limits their application. To address this challenge, …

The Upcoming Moral Crisis In Primitive Artificial Intelligence, Justin E. Edens

Graduate Theses and Dissertations

As we continue to develop artificially intelligent systems, there is an increasingly high chance that we will develop a system that is both conscious and capable of suffering. Furthermore, it is likely that the development of this conscious machine will be entirely unintentional. While this machine will have moral status, identifying it will be extremely difficult, leading to it being treated the same as its inert predecessors. For these reasons I believe that a crisis in ethics is looming. This paper aims to argue that it is possible for a machine to have moral status, that the first such machine …

Utilizing The Horseshoe Prior In Exploratory Factor Analysis And Gaussian Graphical Networks, James Thomas Roddy

Graduate Theses and Dissertations

High-dimensional data analysis frequently involves extracting meaningful structure from noisy, sparse signals. In recent years, Bayesian shrinkage priors—particularly global-local shrinkage priors—have emerged as powerful tools for inducing sparsity while preserving signal fidelity. Among these, the Horseshoe prior has gained notable attention for its capacity to simultaneously shrink irrelevant parameters and retain substantial signals. This dissertation explores the Horseshoe prior as a unified framework for sparse Bayesian inference across theory, simulation, and real-world application. The first component develops new theoretical results establishing the asymptotic Bayes optimality of the Horseshoe prior in Gaussian graphical models (GGMs). We consider sparse precision matrix estimation …