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Evaluating Dosimetric Outcomes In A Prostate Rapid Plan Model: A Comparison Of Prostate Treatment Plans With And Without Standardized Planning Structures, Erica Wartman

Masters Projects

Abstract

Knowledge-based planning (KBP) using RapidPlan (RP) has demonstrated the ability to produce high quality radiation therapy treatment plans while reducing time. This study evaluated whether the inclusion of department specific standardized planning structures, including rings and other optimization tools, improves plan quality when using a prostate and lymph node RP model, or if the model alone is sufficient to provide a quality plan without the use of these additional planning structures.

Ten previously treated Prostate+LN patients were replanned using the departmental RP model in Varian Eclipse treatment planning system.1 For each patient, two plans were created, one with standardized …

Assessing The Costs Of Constructed Floating Wetlands For The Treatment Of Surface Waters And Wastewater, John Awad, Christopher Walker, Declan Page, Muhammad Arslan, Sarah A. White, Terry Lucke, Simon Beecham, Ryan J. Winston, William H.J. Stonsnider, Phil Nicodemus, Chris Streb, John Van Leeuwen

Faculty Publications

The development of constructed floating wetlands (CFWs) as a nature-based solution for water treatment has progressed over the last 25 years. However, full-scale CFW adoption remains relatively limited due in part to the uncertainty regarding the costs of CFWs in terms of capital and operational expenditure (CAPEX and OPEX) and treatment capacity. This study reports on the costs of 11 international CFW schemes including the factors affecting CAPEX and OPEX and levelized costs of nitrogen and phosphorus removal. The estimated levelized CAPEX and OPEX ranged from US$15/m² to $2537/m² and from $0.5/m² y⁻¹ to $181/m² y⁻¹, respectively, for CFW schemes …

Rice (Oryza Sativa L.) Production, Productivity, And Harvested Area In Karawang Regency Under Extreme Weather From 1991-2023, Adine Syabina Buswar, Ruminta, Fiky Yulianto Wicaksono

Jurnal Kultivasi

Climate change occurred in Karawang Regency due to extreme weather events, which are included in the El Nino climate anomaly phenomenon. The existence of extreme weather events in Karawang Regency has decreased rice production, which is a climate-dependent crop. Based on this problem, a study was conducted to analyze the identification of extreme weather changes and correlation analysis of rice crops in Karawang Regency to see the magnitude of extreme weather changes and the influence of extreme weather elements on rice crops. The method used is a quantitative descriptive method by analyzing extreme weather changes, correlation analysis of extreme weather …

Effect Of Preharvest Paclobutrazol And Nitrogen Fertilizers On The Sprouting Performance Of ‘Median’ Potato Seed G0 Tuber, Jajang Sauman Hamdani, Rahmat Budiarto, Anne Nuraini, Selika Fitrian Ramadani

Jurnal Kultivasi

Various intensifications of potato cultivation, such as the provision of paclobutrazol and nitrogen (N) fertilizer, are thought to impact the quality of the seeds produced. This study aims to evaluate the effects of different N fertilizer doses and paclobutrazol concentrations applied in the preharvest period on the sprouting performance of G0 potato tuber seeds after storage. Nine treatment combinations, each repeated three times, were tested, using 50%, 100%, and 150% of the recommended N dose and paclobutrazol concentrations of 50, 100, and 150 part per million (ppm), applied at 30 and 45 days after planting, respectively. The interaction effect between …

The Protective Role Of Resilience In Indirect Aggression Perpetration And Victimization, Amelia Klass

Electronic Theses and Dissertations

This study examines the relationship between resilience and indirect aggression, specifically relational and social aggression, utilizing a sample of 104 females aged 18–22. Indirect aggression, characterized by behaviors such as social exclusion, gossip, and manipulation, is associated with significant emotional and interpersonal difficulties. Using a theoretical basis that includes gender schema theory, social learning theory, and social information processing theory, this study investigates whether resilience has a significant relationship in both the perpetration of and victimization through the use of indirect aggression. Participants completed self-report measures, including the Adult Resilience Measure – Revised and the Young Adult Social Behavior Scales …

Collecting The Strands: A Psychoanalytic Study Of Hair-Pulling In Women, Jacklyn Corsitto

Electronic Theses and Dissertations

This dissertation investigated compulsive hair-pulling (i.e., trichotillomania) in women from a psychoanalytic perspective. The assumption, from a psychoanalytic viewpoint, is that the symptom of hair-pulling serves meaningful, and multiple, psychical purposes that should be analyzed rather than immediately removed, as would be the case in the current gold standard of treatment—behavioral therapy with habit reversal training. This behavioral modality leaves little to no room for exploring the historical, relational, symbolic, and emotional dimensions of hair-pulling. This dissertation fleshed out these dimensions and investigated what hair-pulling was doing for the individual, what its function or purpose was, and, indeed, what ideational …

Identifying The Experiences And Perceptions Of School Psychologists On Racial Disparities In Autism Spectrum Disorderidentifying The Experiences And Perceptions Of School Psychologists On Racial Disparities In Autism Spectrum Disorder, Anna Marie Paolicelli

Electronic Theses and Dissertations

This paper investigates the experiences and perceptions of school psychologists who identify as experts in autism spectrum disorder (ASD) regarding racial and ethnic disparities in ASD identification. Utilizing a convergent embedded mixed-methods design grounded in Consensual Qualitative Research (CQR), the study explores how school psychology practices may have contributed to recent changes in ASD outreach and assessment, as well as persistent disparities, particularly for Black children with co-occurring intellectual disability (ID). Thirteen credentialed school psychologists with extensive experience in diverse educational and clinical settings participated in semi-structured interviews and binary survey items. Findings reveal perceived progress in ASD awareness and …

Understanding The Effects Of Genetic Variation On Maize And Pennycress Root System Architectures And Their Interaction With Nitrogen, Alexander Euway Liu

Arts & Sciences Graduate Student Theses and Dissertations

Roots are a critical yet hidden part of plants, providing physical support and access to resources such as nutrients and water. The development of a plant’s root system across time and space is referred to as root system architecture, which influences the effectiveness of resource capture. In modern agriculture, applications of nitrogen fertilizers are critical to maintain high yield. However, up to 70% of applied nitrogen is not utilized by the plant and escapes into waterways and the atmosphere, causing environmental harm. Efficient nitrogen uptake is limited by the ability of the plant to access and absorb nitrogen through its …

Investigating Food Web Dynamics Of Great Lakes Coastal Wetlands Using A Novel Stable Isotope Approach, Alyssa M. Smith

Masters Theses

Coastal wetlands of the Great Lakes support abundant populations of fish, invertebrates, and vegetation, though the trophic linkages connecting primary production and lower consumers is not well understood in these systems. We implemented a multiple-tracer approach, pairing traditional food web isotope tracers like carbon (δ13C) and nitrogen (δ15N) with total mercury concentrations (THg). We predicted that filamentous algae would be the dominant energy resource in the diet of lower trophic-level invertebrates in the Grand River Estuary, a network of riverine coastal wetlands adjacent to lake Michigan. In addition, we predicted that adding THg as a tracer would improve the resolution …

Should School Board Elections Be Partisan? Analyzing Elite Discourse In The Debate Over The Structure Of Local Elections, Bre'arra M. Long

McNair Summer Research Program

The goal of this research paper is to identify the most prevalent arguments for and against partisan school board elections while also examining what differences, if any, exist between Republicans and Democrats with respect to the way they talk about the issue. The interdisciplinary fields of political science and linguistics provide helpful context to the effectiveness of political communication in smaller scale, yet salient elections in communities where impacts are most directly felt. My interest lies in how the nationalization of politics influences local government and elections, and how language and the media act as conduits for that relationship. It …

The Effects Of Varying Temperatures And Food Availability On The Reproductive Output Of The Acorn Barnacle: Chthamalus Fissus, Karina L. Rog

McNair Summer Research Program

Climate change is predicted to intensify ocean warming and the reduction in phytoplankton abundance, potentially disrupting reproductive processes in filter-feeding intertidal invertebrates. This study investigated the combined effects of water temperature increases and food availability on the reproductive output on Chthamalus fissus, a dominant intertidal barnacle species found along the Southern California coastline. Using a controlled laboratory experiment, adult barnacles collected from the nearshore rocky intertidal habitat in La Jolla, California, were exposed to two temperature regimes (ambient water temperature ~ 18°C and elevated water temperature ~ 20-21°C) and two food concentration treatments (low and high phytoplankton and rotifer …

Regional Heterogeneity Of The Blood-Brain Barrier, Marie Blanchette, Kaja Bajc, Benjamin D Gastfriend, Caterina P Profaci, Nadine Ruderisch, Cayce E Dorrier, Guo Zhong, Raquel Cuevas-Diaz Duran, Sean S Harvey, Iris H Garcia-Pak, Lucija Pintarić, Manon Leclerc, Louise Reveret, Vincent Émond, Annette Wang, Deepti Pant, Linus T Tsai, Frédéric Calon, Nina Isoherranen, Sean P Palecek, Eric V Shusta, Jiaqian Wu, Richard Daneman

The Brown Foundation: Institute of Molecular Medicine

The blood-brain barrier (BBB), formed by specialized endothelial cells (ECs), regulates the extracellular composition of the central nervous system (CNS). Little is known about whether there are regional specializations of the BBB that may control the function of specific neural circuits. We use single cell RNA-seq to characterize ECs from nine CNS regions in male mice: cortex, hippocampus, cerebellum, spinal cord, striatum, thalamus, hypothalamus, midbrain, and medulla/pons. Although there is a core BBB transcriptional profile, there are significant regional specializations. Stra6, a retinoid transporter, is highly enriched in the BBB of the nucleus accumbens shell (ShNAc) and ventral cochlear nucleus, …

Kabasura Kudineer Choornam, A Medicinal Polyherbal Formulation, Modulates Human Macrophage Polarization And Phagocytic Function, Asli Korkmaz, Duygu Ünüvar, Si̇nem Günalp, Derya Göksu Helvaci, Duygu Sağ

Turkish Journal of Biology

Background/aim: Kabasura kudineer choornam (KKC) is a polyherbal formulation of 15 ingredients. It has antiinflammatory and antimicrobial properties and are effective in managing the symptoms of H1N1 swine flu and COVID-19. However, its mechanism of action is not fully understood. In this study, we examined the effect of KKC on the polarization and function of primary human macrophages.

Materials and methods: Human monocyte-derived macrophages (M0 macrophages) pretreated with KKC extract were polarized into M1, M2a, or M2c subtypes. The expression of the M1/M2 polarization markers was analyzed using qPCR, flow cytometry, and ELISA, and the phagocytosis capacity of …

Different Hypoxic Response Of Human Cavii And Caenorhabditis Elegans Homologous Genes Cah-3, Cah-4, Cah-5, Sümeyye Aydoğan Türkoğlu, Aysu Bozkurt, Fatma Poyrazli, Derya Okuyan

Turkish Journal of Biology

Background/aim: A number of carbonic anhydrase (CA) family proteins have been implicated in cancer. They contribute to the hypoxic microenvironment. CAVII is often downregulated in colorectal carcinoma and it has been associated with increased tumor size, node metastasis, and adverse clinical outcomes. In this study, we aimed to investigate the effect of hypoxia on CAVII protein in human colon cancer and prostate cancer cells. In addition, the regulation of CAH genes in Caenorhabditis elegans was examined. These are homologous to CAVII in humans.

Materials and methods: CAVII expression was analyzed in different cell lines such as human colon cancer (SW480 …

Mir-9-5p Alleviates The Development Of Abdominal Aortic Aneurysm By Regulating The Differentiation Of Cd4+Il-10+T Cells Via Targeting The Crosstalk Between Nrf2 And Nf-Κb Signaling Pathways, Hongfu Liu, Jinyi Zhang, Lubin Li, Benxiang Yu, Chunlei Zhang, Wenqiang Niu, Yawen Cheng, Hengyang Dong, Yukun Zhang, Xinlin Luo, Yanlian Xiong, Yueming Wang

Turkish Journal of Biology

Background: Abdominal aortic aneurysm (AAA), a gradual segmental dilatation of the abdominal aorta, is associated with a high mortality rate. The pathophysiological molecular mechanisms underlying AAA remain unclear. In recent years, changes in miRNA levels have been reported to be involved in the development and treatment of AAA. This study aimed to investigate the potential targets and underlying mechanisms of miR-9-5p in attenuating AAA progression by modulating the inflammatory response.

Materials and methods: Biochemical kits were used to measure the levels of inflammatory factors, antioxidant enzyme activity, and serum oxidative stress in normal and AAA model mice. miR-9-5p overexpression was …

Lactic Acid Bacteria Alleviate Neuronal Excitotoxicity And Extend Caenorhabditis Elegans Lifespan, Bao Le, Thi Nhat Hong Nguyen, Seung-Hwan Yang

Turkish Journal of Biology

Aim: Neuronal cell death plays a critical role in the development of neurological disorders associated with aging. This study aimed to evaluate the beneficial effects of heat-killed lactic acid bacteria (hkLAB) on neuroblastoma cells and Caenorhabditis elegans.

Materials and methods: We pretreated heat-killed Lactobacillus fermentum CNU384 (hkCNU384), L. brevis CNU386 (hkCNU386), L. helveticus CNU395 (hkCNU395), and L. paracasei CNU396 (hkCNU396) at a concentration of 10⁹ CFU/mL to investigate their neuroprotective effects on glutamate-induced SH-SY5Y cells and their impact on the lifespan of 6-hydroxydopamine (6-OHDA)-induced C. elegans.

Results: Our findings indicate that hkCNU395 and hkCNU396 protected against glutamate-induced cell death …

Refugee Families: Parental Traumatic Stress And Child Outcomes A Scoping Review, Britta Sedig

Theses and Dissertations

This scoping review synthesizes recent literature (2019-2024) to explore mechanisms linking parental trauma to child mental health outcomes within refugee families. Guided by a systemic and relational focus, 20 studies were identified and analyzed, revealing five central themes: intergenerational transmission of trauma, parenting practices as mediators, parent-child dyadic attachment, family functioning and conflict, and post-migration and acculturative stress. Findings highlighted associations between parental trauma-related symptoms and refugee children's emotional and behavioral concerns. Parenting practices were frequently linked to child wellbeing, with some studies identifying risk factors like harsh discipline and emotional unavailability, and others noting protective roles of intentional caregiving. …

Under What Conditions? A University Pathway Program Evaluation, Michael Burke

Electronic Theses and Dissertations

As U.S. universities face a declining domestic applicant pool, commonly referred to as the “enrollment cliff,” international student recruitment provides a practical strategy for offsetting domestic enrollment shortfalls. One such strategy for increasing international student enrollment is through the establishment of university pathway programs that grant conditional admission to international applicants who fail to meet English language proficiency requirements but are otherwise academically admissible. As a baseline program evaluation, this study utilized a quantitative methods approach employing logistical regression analysis to determine if incoming standardized English language proficiency test scores, English as a Second Language (ESL) course GPA, and student …

Narrative As Story And Ground: Toward A Dialogic Communication Theory Of Narrative Care, Preston Carmack

Electronic Theses and Dissertations

We live in a historical moment when a nuanced understanding of narrative as both ground and story is essential. In examining the work of two primary scholarly voices working with narrative and operating from a communicative lens, Walter R. Fisher and Ronald C. Arnett, this project lays a theoretical foundation for understanding the dialogic interplay of narrative as story and narrative as ground. Through tracing Fisher's and Arnett's contrasting interpretations of the work of Alasdair MacIntyre, a preeminent neo-Thomistic philosopher whose work has significantly contributed to the study of ethics and narrative construction of human rationality, coordinates related to telling …

Sociodemographic, Neighborhood-Level, And Health-Related Factors Associated With Progression To Bariatric Surgery: A Retrospective Chart Review., Angela Godwin

Electronic Theses and Dissertations

Background: Bariatric surgery is the most effective treatment for patients with Class 3 obesity. However, of individuals who start the bariatric surgical process, only about half undergo surgery. Factors associated with completion, including race, have been described; however, consistent evidence on obstacles remains to be identified.

Objectives: To explore variables based on the Social Ecological Model (SEM) that may be related to bariatric surgery completion.

Setting: A large, private hospital with a Bariatric Center of Excellence in New York City

Methods: This retrospective chart review utilized data from adults who established an initial bariatric surgery visit from April 1, 2012, …

Exploration Of The Cultural Beliefs, Values, And Practices Of African American/Black Women Or Birthing Persons Regarding Postpartum Depression: A Focused Ethnography, Stephanie Jacobs

Electronic Theses and Dissertations

Introduction: Postpartum depression (PPD) is the most prevalent perinatal mental health illness in women, affecting approximately 10% to 20% of all women in the United States, and a disproportionately higher number of African American women. The aim of this study was to explore the cultural beliefs, values, and practices of African American/Black women or birthing persons regarding postpartum depression.

Research Question: What are the cultural beliefs, values, and practices of African American/Black women or birthing persons regarding postpartum depression?

Methodology: A focused ethnography was chosen for this study and consisted of semi-structured interviews. Data was transcribed and analyzed …

The Application Of Macrophage-Targeted, Anti-Inflammatory Celecoxib Nanoemulgel For Nerve Regeneration In Peripheral Nerve Injury, Lu Liu

Electronic Theses and Dissertations

Peripheral nerve injury (PNI) refers to damage to the nerve located outside the brain and spinal cord. PNI is commonly caused by a physical accident (trauma) or medical operation^{1, 2}. The impact on the quality of life of PNI patients is directly correlated to neuropathic pain, resultant depression, and increased stress². Even after recovering from the PNI, patients still experience phantom pain and lose the ability to work due to the loss of tactile sensory or motor function^2-4. However, unlike damage to the central nervous system (CNS), peripheral nerves can regenerate because macrophages clean …

Dietary Protein’S Effect On The Gut Microbiome And Its Metabolites: Protocol Description And Virtual Recruitment Efforts For A Remote Randomized Controlled Trial, Karyn M. Gallivan, Kristin S. Ondrak, Denise M. Danos, Meng Luo, Christopher M. Taylor, Lauren E. Meyer, Ann M. Byerley, Alexander W. Nguyen, Sabyasachi Chatterjee, Jiri Adamec, Lauri O. Byerley

School of Medicine Faculty Publications

Fiber’s effect on our gut microbes has been studied extensively, while knowledge of the effect of protein is sparse. Colonic putrefaction of dietary protein is known to produce several potentially detrimental compounds. This randomized controlled trial (RCT) uses a pre- and post-study design to investigate the effect of consuming higher levels of dietary protein on the gut microbiota and the metabolites it produces. Here, we describe our virtual recruitment efforts and RCT protocol. Potential participants lived throughout the contiguous US. Several recruitment methods were employed, of which email reached the largest group of people (approximately 9,100) and generated a 0.3% …

Assessing Greenhouse Gas Emissions From Michigan’S Drowned River Mouths Using In Situ And Remote Sensing Methods, Jillian A. Greene

Masters Theses

Freshwater estuaries are natural contributors to the carbon cycle including production and emission of methane (CH4) and carbon dioxide (CO2), potent greenhouse gases (GHGs); however, estimates of their contribution to regional and global GHG emissions is largely unconstrained. Few studies have examined the quantification and drivers of lake CH4 and CO2 production in the Great Lakes region and how it may differ in response to anthropogenic development. In this study, CH4 and CO2 emissions were measured from three drowned river mouth estuaries (DRMs) along the eastern shore of Lake Michigan in 2024. The DRMs exist along a latitudinal gradient ranging …

Homologous And Heterologous Vaccination Regimens With Mrna And Rvsv Platforms Induce Potent Immune Responses Against Sftsv Glycoprotein, Tomaz B. Manzoni, Jonna B. Westover, Kendall A. Lundgreen, Philip D. Hicks, Raegan J. Petch, Jordan T. Ort, Drew Weissman, Steven H. Y. Fan, Scott E. Hensley, Norbert Pardi, Brian B. Gowen, Paul Bates

Animal, Dairy, and Veterinary Science Faculty Publications

Background: Severe fever with thrombocytopenia syndrome virus (SFTSV) is a highly pathogenic bunyavirus with a high case-fatality ratio for which there is no approved vaccine. Studies have assessed different vaccine technologies. However, few studies have yet assessed the immunogenicity of heterologous prime-boost regimens. Methods: Here, we compare a lipid nanoparticle (LNP)-encapsulated nucleoside-modified mRNA-based vaccine encoding the SFTSV glycoproteins, Gn and Gc, to our recently described recombinant VSV SFTSV (rVSV-SFTSV) vaccine in single dose, homologous, and heterologous prime-boost regimens in mice. Results: We show that all regimens protect from pathogenic SFTSV challenge and elicit strong long-lasting antibody responses. Furthermore, strong cellular …

Effect Of Histidine Tag On The Enzymatic Activity Of Pseudolysin And Its Interaction With The Streptomyces Metalloprotease Inhibitor (Smpi) Protein, Adewale Adeboye Adewole

Electronic Theses and Dissertations

Pseudolysin (PLN) protein is a major virulent factor in Pseudomonas aeruginosa infection. PLN belongs to the family of zinc-dependent metalloproteases. It is naturally inhibited by a smaller protein called streptomyces metalloprotease inhibitor (SMPI), secreted by Streptomyces nigrescens. Previous and current studies demonstrate that the interaction between PLN and SMPI offers unique mechanistic insights for drug development against infections caused by P. aeruginosa. This study investigated the effect of N-terminal Histidine (His) tag on the enzymatic activity of PLN and its interaction with SMPI. His-tagged PLN and SMPI proteins were expressed in bacteria and purified by affinity chromatography …

Post-Drought Growth Recovery Of Tea (Camellia Sinensis) Under Different Techniques And Doses Of Biofertilizer Applications, Nabila Ragil Wiharti, Intan Ratna Dewi Anjarsari, Yudithia Maxiselly

Jurnal Kultivasi

Drought stress is a major limiting factor affecting the growth, yield, and quality of tea (Camellia sinensis). The present study aimed to analyze the success of post-drought growth recovery of tea in response to different techniques and doses of biofertilizer applications. Field experiments were conducted from January to August 2024 in the experimental garden of the Research Institute for Tea and Cinchona, Gambung Blok A8, Bandung. This work was arranged in a split-plot design, consisting of a main plot with two biofertilizer application techniques (foliar feeding and soil drenching) and subplots with four levels of biofertilizer dosage (control (B1), 15 …

Efficacy Of Lactobacillus Rhamnosus And Its Metabolites To Mitigate The Risk Of Foodborne Pathogens In Hydroponic Nutrient Solution, Esther Oginni, Robin A. Choudhury, Veerachandra Yemmireddy

School of Earth, Environmental, & Marine Sciences Faculty Publications

Hydroponic nutrient solution (HNS) has been established as an ideal conduit for pathogen contamination and proliferation. This study evaluated the efficacy of lactic acid bacteria and their metabolites in mitigating the risk of foodborne pathogens in HNS when compared to conventional chemical treatments. Hoagland’s HNS were prepared according to the manufacturer’s instructions and inoculated with Salmonella Typhimurium, Escherichia coli 0157:H7, and Listeria innocua at 105 CFU/mL cell concentration. These nutrient solutions were subjected to treatment with various concentrations of Lactobacillus rhamnosus live cells, a cell-free extract (CFE) of L. rhamnosus metabolites, sodium hypochlorite and peroxyacetic acid at 22 ± 1 …

Where Pipes Meet The Water: Urban Infrastructure In Tijuana, Joab Barrientos

McNair Summer Research Program

Tijuana's rapid urban growth and industrial development have placed significant pressure on its water infrastructure, resulting in ongoing pollution concerns in the Tijuana River Watershed and elsewhere in and beyond the city. In many areas of the city, rapid urban growth has outpaced the building of critical infrastructure like sewage and stormwater systems. These factors have left neighborhoods at risk for a long time. At the same time, industrial growth has often relied on old infrastructure or happened without the right systems in place. Although poor water quality has been a problem for years, few studies have used spatial analysis …

Growth And Yield Of Curly Red Chili (Capsicum Annum L.) In Response To Mulching And Chicken Manure Application In The Erosion-Prone Area Of Loto, Ternate Island, Tri Mulya Hartati, Lily Ishak, Krishna Aji, Chumidach Roini

Jurnal Kultivasi

Information on soil resources in volcanic landscapes presents a high potential for agricultural land development, but its development is always faced with the potential for continuous land degradation. This study aims to reduce the rate of land degradation through the application of vegetative conservation in erosion-prone Loto agrotourism area, Ternate Island. The research location is focused on erosion-prone areas. The research consisted of a soil resource inventory and a vegetative conservation application. The vegetative conservation application method used a Randomized Block Design (RBD) pattern, composed of 2 factors. The first factor is mulching, namely: no mulching (M0) and mulching (M1), …