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Green Synthesis Of Silver Nanoparticles From Melanoleuca Grammopodia: Changes In Bioactive Components, Antidiabetic Properties And Bioaccessibility, İsmai̇l Acar, Emi̇ne Okumuş, Arzu Karataş

Turkish Journal of Agriculture and Forestry

Green synthesis of silver nanoparticles (AgNPs) using plant materials allows the production of low-cost and biocompatible nanoparticles without the use of toxic compounds or solvents. In this study, biogenic AgNP/Mg nanoparticles were synthesized using the Melanoleuca grammopodia mushroom. Vitamin C and E contents of the mushroom were 42.6 mg/g and 26.82 mg/g, respectively. FTIR analysis revealed the reducing and stabilizing effects of bioactive components present in M. grammopodia mushroom extract. SEM micrographs showed that the nanoparticles were spherical in form and the EDX spectrum confirmed the presence of the characteristic metallic silver peak at 3.0 keV. A significant reduction in …

Innovative Approaches To Estimating Sessile Oak Stem Volume: Comparing Additive Models And Ensemble Machine Learning, Maria J. Diamantopoulou, Abbas Şahi̇n, Ramazan Özçeli̇k

Turkish Journal of Agriculture and Forestry

Sessile oak is an important deciduous forest tree species across Türkiye and Europe. Estimating individual tree and stand volumes is essential for growth and yield models, as these predictions play a critical role in assessing forest management, economics, and fire risk. In pursuit of this goal, nonlinear seemingly unrelated regression (NSUR) was used for the simultaneous fitting of stem volume components, and compared to three ensemble machine learning techniques: gradient boosting regression (GBr), XGBoost regression (XGBr), and random forest regression (RFr). NSUR accounts for correlations between error terms across different equations, leading to more efficient parameter estimates than if each …

Welcome To Hotel Thai: Labor, Love, And The Space Between My Mothers, Tripty Tamang Pakhrin

Theses - ALL

This thesis explores maternal labor, silence, and family boundaries through my experience of growing up at Hotel Thai, a restaurant and home located on the open border between Nepal and India. The hotel is run by my three parents: my mother, my father, and his first wife. My two mothers live and work side by side every day but do not speak to each other. Their silence is not emptiness, but a way of surviving and holding the family together. This paper discusses my film, performance, installation, and printmaking works to explore how care, memory, and labor are expressed without …

Asian/Asian American College Students’ Help-Seeking Attitudes For Adhd, Nandini Jhawar

Dissertations - ALL

Background: Asian/Asian American (AA) college students are least likely to engage with ADHD treatment compared to other racially minoritized groups, which may increase their risk for negative outcomes from untreated ADHD symptoms. Public stigma of ADHD contributes to these negative help-seeking attitudes. This study used the minority stress theory to examine if the distal and proximal stress of internalization of the model minority myth, a racial stereotype, influences the relationship between public stigma and help-seeking attitudes. Methods: Participants were undergraduate students recruited from nine geographically diverse universities in the United States. Data was collected over two academic years and included …

Bridging Gaps In Stem: An Evaluation Of A Stem Intervention Program And Its Impact On Degree Attainment And Career Pathways For Low-Income Undergraduate Students, Amanda L. Surman

Dissertations - ALL

Persistent disparities in Science, Technology, Engineering, and Mathematics (STEM) degree completion and career attainment continue to disadvantage students from low-income, firstgeneration, and underrepresented racial and ethnic backgrounds, despite sustained national efforts to diversify the STEM workforce. STEM Intervention Programs (SIPs) have emerged as promising strategies to address these inequities, yet limitations in SIP evaluation literature including the lack of comparison groups, limited longitudinal data, and minimal attention to psychosocial outcomes impede our understanding of their long-term impact. This dissertation uses a mixed-methods, three-project design to evaluate the Strategic Undergraduate STEM Talent Acceleration INitiative (SUSTAIN), a comprehensive SIP at a private, …

Essays On The Health And Labor Market Effects Of Menopause And Menopause Hormone Therapy, Lucia Elvira Torres Frasele

Dissertations - ALL

This dissertation explores how menopause and its medical management affect women’s health and labor market outcomes. Despite the centrality of reproductive transitions in the life course of women, economic research has largely ignored menopause, a biologically and socially significant milestone marking the end of fertility. This omission is surprising, given well-established medical evidence that links menopause to increased risks of health conditions that may impair the ability to work. The dissertation addresses this gap through two chapters that examine the causal impact of menopause and Menopause Hormone Therapy (MHT) on health and labor supply using two distinct empirical strategies. The …

Characterization Of The Molecular Mechanisms Of Noise Stress On Developmental Plasticity In Gryllus Bimaculatus & Co-Teaching And Peer-Led Team Learning In Undergraduate Introductory Biology Courses Toward Expanding Participation In Stem For All, Takunda Maisva

Dissertations - ALL

As part of my training as a Discipline Based Education Researcher (DBER), I gained human subjects educational research experience as well as traditional biology research experience in the laboratory setting. This dissertation explores both my biology education research and traditional developmental biological research. The first and second projects focus on biology education research, examining how Peer-Led Team Learning (PLTL) and modifying introductory biology course instructional design can influence student outcomes in undergraduate Biology education. The third project examines how anthropogenic noise affects the developmental biology of the two-spotted field cricket Gryllus bimaculatus using a genetic approach. Peer-Led Team Learning (PLTL) …

Insights From Multivariate Analysis Of Seed Vigor Traits In Rapeseed And Mustard (Brassica Spp.) Genotypes, Ayushi Yadav, Shiv Kumar Yadav, Ravish Choudhary, Sushma Mudlupura Kumar, Anbalagan Anumantharaj, Rakesh Bharadwaj, Rashmi Yadav, Yashpal Taak, Navinder Saini, Sneha Adhikari, Sangita Yadav

Turkish Journal of Agriculture and Forestry

Rapeseed and mustard (Brassica spp.) are critical oilseed crops contributing significantly to global edible oil production. In India, Indian mustard (Brassica juncea) dominates Brassica cultivation, yet the country remains heavily dependent on edible oil imports due to insufficient domestic production. Enhancing seed vigor, a key determinant of crop establishment and yield, offers a promising avenue for improving productivity. This study assessed the genetic diversity of 300 rapeseed and mustard genotypes for seed vigor traits using multivariate analysis, including principal component analysis (PCA) and cluster analysis. Eleven seed vigor-related traits were evaluated, and PCA revealed four principal components with eigenvalues greater …

Effects Of Polyethylene Films With Different Uv-A Transmittance On Quality Parameters And Physiology Of Greenhouse-Grown Tomato, Nefi̇se Yasemi̇n Tezcan, Mustafa Erkan, Ahmet Kurunç

Turkish Journal of Agriculture and Forestry

In this study, the effects of three different polyethylene (PE) greenhouse covering materials (CMs) with varying thicknesses and ultraviolet-A (UV-A) transmittance on greenhouse microclimate, plant growth, yield, fruit quality, and chlorophyll fluorescence parameters (Chl FPs) in tomatoes were investigated. The CMs used in the study were 180 μm thick ultraviolet (UV) + ethylene vinyl acetate (EVA) + long-wave infrared (IR) + light diffuser (LD) + antifog (AF) added PE (CM1), 160 μm thick PLUS UV + EVA + IR + LD + AF added PE (CM2), and 200 μm thick UV + EVA + IR + LD added PE (CM3). …

Engineering Protein Linkers For Optimized Telsam-Darpin Fusion And Crystallization With Electric Field-Based Polymer Orientation, Maria Jose Pedroza Romo

Theses and Dissertations

Fusing a variant of the sterile alpha motif domain of the human translocation ETS leukemia protein (TELSAM) to a protein of interest significantly enhances crystallization and diffraction quality. TELSAM is a pH-dependent, polymer-forming crystallization chaperone that, when covalently fused to a protein, forms a well-ordered crystal lattice. However, the success of this method depends on two factors: 1) the design of the linker connecting TELSAM to the target protein, which influences both crystal packing and target orientation, and 2) the prevention of TELSAM polymer flipping, a phenomenon that disrupts lattice periodicity and impairs structure determination. To address the first challenge, …

Cost-Effectiveness Model For Reservoir Sediment Management Economics, Connor Ronald Hale

Theses and Dissertations

Reservoir sediment deposition poses a challenge to sustainable water supplies around the world. Sediment management has proven to be an expensive endeavor. Two models have been developed to guide economic analysis for reservoir sediment management, namely the Reservoir Sediment Economics Model (RSEM) and the Reservoir Conservation Model 2 (RESCON 2). While these are helpful tools for benefit-cost prefeasibility studies, they rely heavily on sometimes elusive estimations of the benefits of water supply. In this study, a new method for economic analysis is proposed that foregoes benefit-cost analysis in favor of a cost-effectiveness approach. The Sediment Management Cost-Effectiveness Model ranks sediment …

Prediction Of Drug-Induced Cardiotoxicity Using Machine Learning Analysis Of Hipsc-Cm Contractile Profiles, Anthony Allan Watt

Theses - ALL

Drug-induced cardiotoxicity remains a critical concern in pharmaceutical development as failed drug candidates result in lost time and resources that could be better spent on viable candidates. We believe that a robust in vitro model that accurately captures human cardiac physiology is an applicable model for examining drug candidates. In addition to those models, there is a need for quick and effective predictive models to analyze data obtained from the model to classify drugs based on their potential for cardiotoxicity. In this study, we conduct a functional analysis of human-induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) and pass the data collected …

Decreasing Foraminiferal Flux In Response To Ongoing Climate Change In The Santa Barbara Basin, California, Emily Harvard, Katherine Cherry, Claudia R. Benitez-Nelson, Eric Tappa, Catherine V. Davis

Faculty Publications

The rapid response of foraminiferal assemblages to changing climate makes their shells an invaluable geological record of the past. However, the time frame over which foraminifera respond to climatic signals and the specific drivers influencing assemblage composition and abundance remain obscure. We focus on the impact of ongoing, anthropogenic climate change on planktic foraminifera in the California Current ecosystem, which would appear as a nearly instantaneous event in the sediment record. The Santa Barbara Basin sediment trap, located off the coast of California, USA since 1993, provides a record of more than 30 years of particulate and foraminiferal flux in …

In Defense Of Metaphysics: A Defense Of The Value And Methodological Soundness Of Metaphysics Understood As Structural Modeling, Sean Nalty

Dissertations - ALL

The aim of this dissertation is to provide a defense of the value and methodological soundness of contemporary analytic metaphysics against a variety of recent anti-metaphysical and scientistic critiques. In Chapter 1, I attempt to answer (at least provisionally) a surprisingly difficult question: what is metaphysics, anyway? I suggest seven adequacy constraints on an answer to this question, and then test five historically and contemporarily influential candidate characterizations of metaphysics against these constraints. Finding each candidate lacking, I close by proposing an ecumenical conception of metaphysics — what I call the structural modeling conception — according to which metaphysics aims …

Assessment Of Bat Species (Mammalia: Chiroptera) In Canubas Cave, Kibawe, Bukidnon, Philippines, Jurriel Mari D. Alce, Jasmine Rouida M. Abenes, Leo Gabriel Cervantes, Matthew Eli K. Llacer, Von Zhyrus P. Oche, Ian Jay P. Saldo, Jhovel Roy D. Calo

Sinaya: A Philippine Journal for Senior High School Teachers and Students

Bats, flying mammals, are essential to ecosystems, playing vital roles in pollination, seed dispersal, and insect control. Despite their ecological importance, no prior bat research exists for Canubas Cave, Kibawe, Bukidnon. This study aimed to assess the bat species at the site, documenting their morphometric data, diversity and richness indices, and conservation statuses. A purposive sampling design was implemented by setting up mist nets inside and outside the cave. A total of 13 individuals were identified, comprising three species from two families: Rousettus amplexicaudatus and Eonycteris spelaea (family Pteropodidae, fruit bats), and Miniopterus schreibersii (family Miniopteridae, bent-winged bats). Based on …

Milkfish (Chanos Chanos) Bones As A Biosorbent For Mercury (Ii) Contamination In Water, Seth Uriel K. Neri, Ethan Kyle Mangao, Christian Kevin F. Redoblado, Anthony Cesar Y. Ponce, Roby Boy P. Riego, Jupiter O. Yap

Sinaya: A Philippine Journal for Senior High School Teachers and Students

Heavy metals, such as mercury contamination in water sources are a major environmental and public health issue in many countries. Traditional methods for removing heavy metals from water are effective but often costly and unsustainable and may produce secondary waste. Recent trends favor more sustainable alternatives, such as biosorbents in treating water with heavy metals. Milkfish (Chanos chanos), a common fish in the Philippines, contains hydroxyapatite in the bones that can bind with heavy metals through physical and chemical adsorption mechanisms. This study aims to evaluate the mercury (II) reduction capacity of biosorbent derived from milkfish bones in water, specifically …

Building Family Partnerships Toward Equitable Community Engagement And Integration In Stem Education, Juan Salinas, Sheila Cardenas-Vazquez, Sherlyn De Alva, Elizabeth Salinas, Griselda Salinas, Virginia Santanas

Organization and School Leadership Faculty Publications

In their quest to further their understanding of the power of plática (authentic dialogue) in community engagement efforts, the researchers/practitioners embedded themselves in deep, critical conversations with family leaders from a community-based organization on issues of equity and excellence in education. A family-centered theory of change developed by trusting relationships and partnerships with students, their families, and educators, was incorporated in the professional development of STEM faculty, revision of STEM curricula, and the transformation of teaching practices. This study advances the body of knowledge on the operationalization of servingness and provides insight on the utilization of sense of belonging metrics …

Premenopausal And Postmenopausal Malignant Cervical Cancer Diagnosis Among Disaggregated Subethnic Groups Of Asian American Women In The United States, Nilofar Haider Mirza

Walden Dissertations and Doctoral Studies

Despite being the United States' fastest-growing and diverse population, Asian Americans are often aggregated with Native Hawaiian and Pacific Islanders in prior research, resulting in masking disparities in cervical cancer screening/diagnosis among Asian American subethnic groups. Guided by Bronfenbrenner's ecological model, the association between disaggregated subethnic groups and cervical cancer diagnosis among Asian American women aged 20+ in the United States was examined using binary logistic regression. How histology type/behavior and age at diagnosis moderate the relationship between disaggregated subethnic groups and cervical cancer diagnosis was also explored. A quantitative cross-sectional design was employed using cases (N=1014) from the U.S. …

Characteristics And Effectiveness Of Premarital Thalassaemia Educational Interventions Worldwide: A Scoping Review, Maisarah N. Anwar, Nik Nairan Abdullah, Dalila Roslan, Aimi N.M. Ruzlin

Sultan Qaboos University Medical Journal

Thalassaemia, a hereditary blood disorder, remains under-recognised due to limited awareness, particularly among young people. This scoping review aimed to evaluate the characteristics and effectiveness of premarital thalassaemia educational interventions globally. Following PRISMA-ScR guidelines, six databases were searched for English-language studies targeting adolescents and young adults. Eight studies met the inclusion criteria, and data were extracted using a standardised form adapted from the Joanna Briggs Institute, focusing on intervention characteristics, outcomes and key findings. Most studies involved school students and young adults from culturally diverse, resource-limited settings. The interventions—traditional, technology-based or culturally adapted—consistently improved knowledge (P < 0.001). However, behavioural outcomes, such as increased uptake of screening, were inconsistent. While educational strategies enhanced knowledge effectively, socio-cultural barriers limited the translation into behavioural changes. These findings support the need for future interventions to integrate behavioural change theories, leverage digital tools and address cultural sensitivities to improve their overall impact.

Satellite-Based Identification Of Mesoscale And Submesoscale Eddies And Fronts In The Gulf Of Mexico, Ethan Cruz

Theses and Dissertations

Mesoscale and submesoscale processes in the Gulf of Mexico (GoM) are fundamental in shaping the region’s physical and biogeochemical ocean dynamics. Advances in high-resolution satellite observations now allow detailed detection of submesoscale (< 25 km radius) and mesoscale eddies and ocean fronts, which drive heat, nutrient, and carbon fluxes. This dissertation integrates two complementary investigations: (1) a comparison of eddy-tracking algorithms: Contour Tracing (CT) and Temperature Thresholding (TT), applied to Optimum Interpolation Sea Surface Temperature (OISST, 1/4°) and Operational Sea Surface Temperature and Ice Analysis (OSTIA, 1/20°) products; and (2) a comparative evaluation of three ocean front detection algorithms: Canny Edge Detection (Canny), the Cayula–Cornillon Algorithm (CCA), and the Belkin–O’Reilly Algorithm (BOA), across multiple satellite-derived parameters, including sea surface temperature (SST), sea surface salinity (SSS), chlorophyll-a (Chl-a), and altimetry-derived absolute dynamic topography (ADT). The eddy-tracking analysis shows that the higher-resolution OSTIA consistently detected more eddies than OISST, with TT performing best during winter when SST gradients were strongest. The front detection analysis, incorporating datasets from the Surface Water and Ocean Topography (SWOT) and Plankton, Aerosol, Cloud, Ocean Ecosystem (PACE) missions, was evaluated under diverse conditions, including flood and drought periods, Loop Current phase changes, and extreme weather events. A machine learning–based Gaussian Mixture Modeling (GMM) approach was also developed, providing a novel framework for dynamic front detection. By benchmarking traditional and machine learning methods, this integrated study identifies optimal algorithm–dataset combinations for resolving submesoscale and mesoscale features in the GoM, with applicability to other regions.

Black Mothers' Adhd Experiences, Attitudes, And Support-Seeking Decisions, Catherine L. Montgomery

Dissertations - ALL

Background: ADHD, particularly when left untreated, is associated with significant impairment in several domains. Black youth may still be under-diagnosed with ADHD, resulting in symptoms going untreated. Black mothers may determine non-professional delivered supports to be more appropriate and acceptable than medication for their children with ADHD. As they tend to be the primary healthcare decision makers, it is important to develop a greater understanding of Black mothers’ ADHD support-seeking decision making for their youth. Method: The present study used semi-structured interviews guided by Kleinman’s Explanatory Models of Illness to discuss Black mothers’ decision making for their youth with ADHD. …

The Impact Of Adhd On Entrepreneurship Through A Gender Lens Three Essays, Mi Hoang Tran

Dissertations - ALL

This dissertation investigates how neurodiversity, specifically attention-deficit/hyperactivity disorder (ADHD), relates to entrepreneurial behaviors and outcomes, with a specific attention to gender as a moderating factor. The first essay provides a comprehensive meta-analytic review of 44 empirical studies, synthesizing 261 effect sizes to assess the relationship between ADHD and different stages of the entrepreneurial process: attitudes, behaviors, and post-launch outcomes. Results reveal that hyperactivity/impulsivity symptoms are positively associated with entrepreneurial attitudes and behaviors but unrelated to post-launch outcomes, while inattention symptoms are negatively associated with outcomes. These findings offer evidence that ADHD’s impact is phase-specific and contingent. The second essay draws …

Technological Revolutions And Advertising: Historical Innovation Cycles, Ai, And The Future Of Platform Power, Christopher J. Lorusso

Dissertations - ALL

This study explores the future of advertising amidst a digital landscape increasingly shaped by artificial intelligence (AI). Leveraging Carlota Perez’s Technological Revolutions and Financial Capital framework, it examines how AI is poised to further disrupt the advertising ecosystem through the key elements of automation, user data, and inventory. Collectively, these dynamics have become key drivers of platform power, with implications for user behavior, competitive strategy, and the societal diffusion of AI technology more broadly. Employing a thematic analysis across historical and contemporary cases of advertising technology, the research identifies five themes worthy of strategic and scholarly consideration. Two primary themes—Dependency …

Caf-Macrophage Crosstalk Fuels Immunotherapy Resistance, Yang Liu, Linghua Wang

Faculty, Staff and Student Publications

No abstract provided.

Ectopic Adipose Tissue In Subsistence Populations With Minimal Coronary Disease, Large Left Atria, And Very Low Rates Of Atrial Fibrillation, Randall C. Thompson, Benjamin C. Trumble, Daniel K. Cummings, Angela D. Neunuebel, Paul L. Hooper, Samuel Wann, Adel H. Allam, Frances Neunuebel, Benjamin D. Gans, Samantha I. King, Edmond Seabright, Caleb E. Finch, Margaret Gatz, Kenneth Buetow, Michael I. Miyamoto, Guido P. Lombardi, M. Linda Sutherland, James D. Sutherland, Christopher J. Ward, Madeleine J. Lee, Ashna Mahadev, Daniel Eid Rodriguez, David E. Michalik, Chris J. Rowan, Tianyu Cao, Jonathan Stieglitz, Cameron M. Quick, Gregory S. Thomas, Jagat Narula, Damini Dey, Michael Gurven, Hillard Kaplan

ESI Publications

Background

Methods

Challenging Life Events Of Undergraduate Students, Kristi Lewis, Gayle Roux, Catherine Dingley

The Qualitative Report

College students often face many difficult or stressful personal life events such as academic pressure, financial worries, family stress, or a relationship breakup. These events can impact their mental health and academic performance. Amid the growing mental health crisis on college campuses, it is important to explore the strategies that college students employ to tackle challenging life events. The purpose of this study was to (1) explore the experience of college undergraduates as they navigate challenging life events; and (2) examine strategies and resources utilized by the students. We conducted a qualitative descriptive study informed by phenomenology (Giorgi, 2009) using …

A 6-Month, Prospective Randomized Controlled Trial Of The Targeted Management (Team) Intervention Vs. Enhanced Treatment As Usual Among Ugandans At Risk For Stroke, Carla Conroy, Joy Yala, Christopher J. Burant, Shirley Moore, Martha Sajatovic

Faculty Scholarship

Background Among low and middle-income countries, especially in Sub-Saharan Africa, the stroke burden is severe, with increasing trends in stroke incidence, prevalence, and mortality. Aims This 6-month, prospective randomized controlled trial (RCT) compared a novel stroke risk reduction approach (TargetEd manAgeMent Intervention (TEAM)) vs. Enhanced Treatment as Usual (ETAU) in 247 Ugandans at risk for stroke. Methods Participants, enrolled across 3 Ugandan sites, were adults with high stroke risk. The primary outcome was a change in systolic blood pressure (SBP) from baseline to 6-month follow-up. Secondary outcomes included changes from baseline to 6 months on diastolic BP (DBP), serum lipids, …

Targeting Fear Of Cancer Recurrence With Internet-Based Emotional Freedom Techniques (Ieft) And Mindfulness Meditation Intervention (Immi) (Bgog-Gyn1b/Remote), Laura Tack, Lore Mertens, Marte Vandeweyer, Fien Florin, Emma Pauwels, Thaïs Baert, Tom Boterberg, Christel Fontaine, Kurt Geldhof, Caroline Lamot, Christine Langenaeken, Jeroen Mebis, Laure-Anne Teuwen, Katherine Vandenborre, Heidi Van Den Bulck, Florence Van Ryckeghem, Mohammad Najlah, Patricia Schofield, Philip R. Debruyne

School of Nursing and Midwifery

Approximately one-third of cancer survivors report a need for professional help to cope with Fear of Cancer Recurrence (FCR). In the REMOTE trial, we aim to investigate the efficacy of two internet-based mind-body techniques to address this currently unmet medical need. Cancer survivors, screened using the Cancer Worry Scale (CWS), are randomly assigned to one of the three study groups: (1) internet-based emotional freedom techniques (iEFT) (n = 113), (2) an active control condition internet-based mindfulness meditation intervention (iMMI) (n = 113), or (3) a wait-list control group (WLC) (n = 113). The interventions iEFT and iMMI are conducted remotely …

Multivariate Protein Landscape Of Host Response In Hospitalised Patients With Suspected Infection In The Emergency Department, Pratik Sinha, Et Al.

2020-Current year OA Pubs

Suspected infection requiring hospitalisation has highly heterogenous presentation. Yet, variances in host response and its implications are largely unknown. In this multicentre cohort of 3802 individual patients presenting to the Emergency Department (ED) with suspected infection requiring hospitalisation, we apply uniform manifold approximation and projections and K-means clustering to 29 plasma proteins to identify biologically discrete host response clusters. In this work, we first describe two large clusters, called "Dysregulated" and "Undifferentiated", with abnormal protein concentrations and adverse outcomes in the former. Through further clustering, we identify 4 sub-clusters in the Dysregulated cluster, each with discrete biological signatures, clinical correlates, …

Dynamics And Lipid Membrane Coupling Of The Ras-Raf Complex Revealed Via Multiscale Simulations, Timothy S. Carpenter, Fikret Aydin, Chris Neale, Que N. Van, Xiaohua Zhang, Harsh Bhatia, Jason W. Sidabras, Peter H. Frank, Konstantia Georgouli, Jeremy O.B. Tempkin, Violeta Burns Casamayor, Gulcin Gulten, Rebika Shrestha, Debanjan Goswami, Francesco Di Natale, Joseph R. Chavez, Liam G. Stanton, For Full Author List, See Comments Below

Faculty Research, Scholarly, and Creative Activity

To gain molecular and mechanistic insights into initiation of the RAS-RAF signaling cascade, we developed and used a combination of multiscale simulation and experimental approaches. The influence and impact of the membrane on RAS and RAF proteins is a factor we are just beginning to understand and appreciate in more detail. Molecular simulation is an ideal methodology to further study this complicated relationship between the membrane and associated proteins. Our previous work using Multiscale Machine-learned Modeling Infrastructure investigated different lipid compositions solely around the KRAS4b protein and the interplay between protein behavior and these membrane environments. Multiscale Machine-learned Modeling Infrastructure …