Digital Commons Network^™

Evaluating Curriculum Alignment In University-Level Organic Chemistry Programs Using N-Valued Neutrosophic Trapezoidal Numbers, Huaying Gao, Hongchang Liu

Neutrosophic Sets and Systems

No abstract provided.

Enhanced Multi-Criteria Dna Sequence Analysis Using Neutrosophic Logic And Deep Learning: An Integrated Approach For Comparison And Classification, Romany M. Farag, Mahmoud Y. Shams, Dalia A. Aldawody, Hazem M. El-Bakry, Huda E. Khalid, Ahmed K. Essa, A. A. Salama

Neutrosophic Sets and Systems

No abstract provided.

A Neutrosophic Superhyper Number Framework For Accurate Statistical Evaluation Of Financial Performance In High-Tech Enterprises, Yujuan Xie

Neutrosophic Sets and Systems

No abstract provided.

Upper Peninsula Regional Economic Development Strategy, Iryna V. Lendel, Chloe Wieber, Gerrit Anderson, Sevrin Williams

Upjohn Institute Technical Reports

This comprehensive report describes the economy of Michigan’s Upper Peninsula, outlining both persistent issues and emerging opportunities. The region faces several structural challenges, including a decline in prime-age workers and bachelor’s degree attainment that falls below state and national averages, while shortages in housing and healthcare further limit its ability to attract and retain residents. Despite those challenges, the U.P.’s universities, longstanding industries, abundant natural resources, and robust outdoor recreation economy provide strong foundations for future development. The report recommends strategies such as strengthening retention of the talent pipeline, expanding housing and healthcare capacity, fostering small and mid-sized firms in …

Ptsd Symptoms Moderate Predictors Of Psychophysiological Arousal During Fear Inhibition: Evidence From A Fear, Reward, And Neutral Discrimination Task, Jacklynn M. Fitzgerald, E. Kate Webb, Kaley Davis, Meghan Bennett, Tristan Benjamin, Boiana Pegau, Susan Sangha

Psychology Faculty Research and Publications

The ability to distinguish between threatening, rewarding, and neutral cues is adaptative and crucial for survival. However, individuals with posttraumatic stress disorder (PTSD) often show poor knowledge of cue contingencies and heightened fear responses even in the presence of cues that signify safety, potentially due to atypical perceptions of neutral cues. We investigated whether perceiving neutral cues as more rewarding or threatening influences conditioned inhibition of fear and whether PTSD symptoms moderate this relationship. Trauma-exposed adults (N = 84; 64 % female; 76 % non-Hispanic white) completed a Fear, Reward, and Neutral Discrimination (FRND) Task involving geometric shapes paired with …

Searching For Meaning In A Chaotic World: An Analysis Of Tina Howe’S Birth And After Birth, Ali Qasim Radhee, Sabah Atallah Khalifa Ali

Alustath Journal for Human and Social Sciences

This paper deals with Tina Howe’s play Birth and After Birth as an absurd work. The aim is to harbor on meaning out of the chaotic life of the characters in the play. Topics like motherhood, archetypes, domestic abuse and social bias are discussed in this paper. The implementations of these topics help in shedding light on the motives behind the characters’ actions and consequently reach out to a better understanding of their behaviors and those of the American people in general.

Howe’s work reflects the traditional life of a stereotypical American family during the 1970s, a life that is …

Symptoms Of Anxiety And Depression In Mothers Of Children With Autism Spectrum Disorder, Hawra Muhammad Khrebit, Iman Hasan Jadan

Alustath Journal for Human and Social Sciences

The current research aimed the anxiety and depression scale of (HADS, 1983). The scale consisted of (14) paragraphs, and the sample size of the research was (145) mothers of autistic children in Baghdad Governorate, both sides of Karkh and Rusafa

Reaching International Consensus On The Definition Of Refractory Migraine Using The Delphi Method, Jennifer Robblee, Fawad A. Khan, Michael J. Marmura, Hope L. O'Brien, Lawrence D. Robbins, Marielle K. Samaha, Morris Levin, Simona Sacco, Raffaele Ornello, Stephanie J. Nahas, Heike Hesse, Annika Ehrlich, Adam S. Sprouse-Blum, Christina Sun-Edelstein, Bronwyn Jenkins, Elizabeth K, Seng, Shivang Joshi, Meredith J. Barad, Mi Ji Lee, Sheena K. Aurora, Mario Fernando Prieto Peres

Department of Neurology Faculty Papers

Aim: Despite its frequency in tertiary headache centers, the International Classification of Headache Disorders, 3rd edition (ICHD-3) does not include refractory migraine. Multiple definitions have been proposed with a recent 2020 proposal for both refractory migraine and resistant migraine by the European Headache Federation (EHF). The aim is to reach an international consensus on the definition of refractory migraine.

Methods: This study is a Delphi consensus carried out by a group of international experts in headache medicine. Following a focus group, a panel of 20 experts and one facilitator reviewed the EHF proposed criteria to build upon their definitions. The …

Developmental Transformations Of Purkinje Cells Tracked By Dna Electrokinetic Mobility, Cheryl Brandenburg, Garrett W Crutcher, Andrea J Romanowski, Sarah G Donofrio, Lita R Duraine, Richard N A Owusu-Mensah, Benjamin H Cooper, Izumi Sugihara, Gene J Blatt, Roy V Sillitoe, Alexandros Poulopoulos

Duncan NRI Faculty and Staff Publications

Brain development begins with neurogenesis in progenitor zones and ends with expansive, intricately-patterned cellular diversity in the adult brain. We took advantage of bioelectric interactions between DNA and embryonic tissue to perform "stereo-tracking," a developmental targeting strategy that differentially labels cells at different depths within progenitor zones. This 3D labeling was achieved by delivery of plasmids with distinct electrokinetic mobilities in utero. We applied stereo-tracking with light sheet imaging in the cerebellum and identified that Purkinje cells follow embryonically committed developmental trajectories, linking distinct progenitor zone subfields to the mature topography of the cerebellar cortex. We additionally identified an unexpected …

Young People’S Experiences Of Living With Endocrine Conditions., Hannah Godfrey, Alyson Norman, Susan Jackson, Yasmin Steven

School of Psychology

Background: The management of endocrine conditions can beproblematic and have a detrimental impact on mental wellbeing. Despitethe large number of young people with a range of endocrine conditions,research is limited on the psychological and physical impact of theconditions on their daily lives.Aim: To explore the lived experiences of young people aged 10 to 25 withendocrine conditions regarding condition management and psychosocialsymptoms.Methods: Nine young people aged 11 to 25 years (all female) took part insemi-structured interviews about the impact of their condition. Data wereexplored using thematic analysis.Findings: Three themes were identified: impact on daily life (includingcondition management, organisation, impact on work …

Case Series: Atrx Variants In Four Patients With Metastatic Pheochromocytoma, Briana Noel Cortez, Mickey J. M. Kuo, Abhishek Jha, Mayank Patel, Jorge A. Carrasquillo, Tamara Prodanov, Kailah M. Charles, Sara Talvacchio, Alberta Derkyi, Frank I. Lin

School of Medicine Publications

Few reports have highlighted the rare presence of somatic ATRX variants in clinically aggressive, metastatic pheochromocytoma/paraganglioma (PCC/PGL); however, none have addressed detailed clinical presentation (including biochemistry and imaging) and management of these patients. Here, we address these clinical features and management based on four PCC patients with somatic ATRX variants from our National Institutes of Health PCC/PGL cohort. A total of 192 patients underwent exome sequencing (germline, somatic, or both), and four males were found to have somatic ATRX variants (with additional somatic VHL and FH oncogenic variants in patients 2 and 4, respectively). Per-lesion and per-patient comparisons were performed …

British Academic Psychiatry At A Crossroads: Lessons From The Past 20years And Priorities For The Next 20 Years, Rohit Shankar, Laura Bowater, Richard Laugharne, Derek K. Tracy, Hugo Critchley, Allan H. Young, John R. Terry, Dinesh Bhugra, Regi Alexander

Peninsula Medical School

The past twenty years, British academic psychiatry has made significant scientific advances in neurosciences, psychopharmacology, imaging and genetics with patients increasingly being involved as research partners. However, this progress has coincided with marked structural deterioration. Despite a 50% expansion in medical school places and rising mental health needs, full-time academic psychiatrists numbers fell from 330 in 2004 to 206 in 2023. This reduction has constrained research capacity, limited educational opportunities, and exacerbated regional disparities. The current academic landscape is precarious. While research-active services deliver demonstrably better patient outcomes and service outcomes (productivity/efficiency), the research workforce remains small and unevenly distributed. …

A Retrospective Cohort Study Of Valproate And Infertility In Men With Epilepsy Or Bipolar Disorder Using International Health Data, Lance Watkins

Peninsula Medical School

Valproate is highly effective at treating epilepsy and bipolar disorder. It faces prescribing restrictions in men due to concerns it causes testicular dysfunction and infertility. These mostly stem from animal models – the human evidence is limited and conflicting. We report the largest ever retrospective cohort study of infertility in men with epilepsy or bipolar disorder, using real-world healthcare data from TriNetX. 91,917 of the men are exposed to valproate, and 535,803 unexposed. Cohorts are propensity score matched for a comprehensive set of baseline covariates, and survival analysis is undertaken using Cox-proportional hazards models. No significant difference is seen between …

Alpiscorpius Huyukensis Sp. N., An Unexpected New Species From Sultan Mountains, Konya Province, Turkey (Scorpiones: Euscorpiidae), Ersen A. Yağmur, Halil İ. Yaylı

Euscorpius

A new scorpion species, Alpiscorpius huyukensis sp. n., is described from the western foothills of the Sultan Mountains, Konya Province, in the Aegean Region of western Turkey, based on morphological characters. The species is assigned to the genus Alpiscorpius Gantenbein et al., 1999, due to the presence of three trichobothria in the em series on the external surface of the pedipalp patella. A. huyukensis sp. n. can be readily distinguished from its all congeners by its yellowish-orange or greyish-orange body and yellow metasomal coloration, the fifth metasomal segment bearing distinct ventrolateral carinae, the presence of six trichobothria in the …

Hematologic And Serum Biochemical Reference Intervals For Formosan Sika Deer (Cervus Nippon Taiouanus) From A Semi-Free-Ranging Population In Taiwan, Chen-Wei Wang, Ke-Lun Chen, Hung-Yi Wu, Chia-Ying Lin

The Thai Journal of Veterinary Medicine

The Formosan sika deer (Cervus nippon taiouanus), an endemic Taiwanese subspecies, holds a pivotal role in local conservation. This study addresses a significant knowledge gap by establishing population-specific reference intervals (RIs) for this species, as existing RIs are based on limited captive populations and may not accurately reflect the health of semi-free-ranging cohorts. We analyzed 632 sampling events from 232 healthy adult deer within Kenting National Park over 12 years (2013–2024). This study adhered to ASVCP guidelines, establishing instrument-specific RIs and employing linear mixed-effects models (LMMs) to evaluate the complex interactions among analytical instruments, sex, and body weight. …

A Comparative Study Of Cities To Develop An Assessment Framework For Climate-Resilient Cities, Aya Mohamed Elsawaf, Ayman G. Abdeltawab, Engi Ibrahem El-Darwish, Walaa Abou El-Haggag Mehanna

Journal of Engineering Research

As climate change intensifies, urban areas face increasing hazards from extreme weather events such as rising sea levels, heat waves, and heavy rainfall. Resilient cities—those developed to absorb, recover, and adapt to these shocks—are crucial in protecting residents and infrastructure. This paper explores the concept of urban resilience, highlighting its multifaceted aspect, including recovery, adaptability, and transformation. It focuses on how to solve these climate change challenges by implementing resilience strategies and practices that achieve a number of criteria and indicators to be a climate-resilient city. A collection of global frameworks for measuring resilience in general is discussed in addition …

Designing Childhood Spaces: Towards An Architecture That Responds To The Child’S Innate Needs And Enhances Interaction, Abdelrahman Mohamed Mousa

Journal of Engineering Research

: The creation of a building for children is no longer just a shelter, but rather a spatial unit for 2020, a diverse and generally direct difference in building the child's personality, which limits the strengthening of control over the child on the one hand, and the direction in which he lives. It is a loud cry, one that is diverse: children have realized us, and the reference to the cry is that we find ourselves participating in dealing properly with children and also in society years later. It is believed that attention to children during the preschool stage significantly …

Exploring The Role Of Localized Indigenous Knowledge In Developing Urban Water Resilience And Sustainability Strategies In Egypt, Nevine Ismail Mahmoud, Amira Fawzy Helmy Almaz, Amany Ragheb

Journal of Engineering Research

Urban areas worldwide face water challenges due to population growth, climate change, and inadequate construction. To tackle these issues, cities are experimenting with green infrastructure, rainwater harvesting, and wastewater recycling, integrating local data and sustainable construction methods to mitigate water scarcity and increase resilience.

This paper discusses using natural data in urban water management to tackle water scarcity, flooding, and quality issues. It suggests that this data can improve urban practicality and human well-being by addressing shared urban areas and the physical environment. Implementing natural enhancements like water harvesting, floodplain management, and shared filtration systems can enhance water quality and …

Flexural Behavior Of Sustainable Concrete Beams Containing Waste Tire Fibers And Recycled Aggregates, Wael M. Montaser Ass.Prof

Journal of Engineering Research

The increasing accumulation of diverse waste materials poses a significant societal challenge, highlighting the importance of developing methods to reuse such waste effectively. One promising solution involves incorporating recycled coarse aggregate (RCA) obtained from demolished concrete into new concrete mixtures. Additionally, tire-derived fibers (TDF), sourced from recycled tires, present an environmentally friendly substitute for conventional reinforcement materials. The integration of RCA with TDF in reinforced concrete beams offers a sustainable approach to enhancing structural performance. This experimental study investigates the flexural performance of reinforced concrete beams containing recycled coarse aggregate (RCA) and tire-derived fibers (TDF). Four mixes with varying RCA …

Assessment Of Radiological Risk Hazard Indices For Diverse Environmental And Biological Samples: A Comprehensive Review, Israa K. Ahmed, Sabah S. Farhan, Jamal M. Rzaij

Al-Bahir

Radiological risk assessment is pivotal for safeguarding human health and ecosystems amid expanding radiation applications in technology and medicine. This review systematically evaluates the efficacy of hazard indices like the Annual Effective Dose Equivalent (AEDE) and Excess Lifetime Cancer Risk (ELCR) across environmental (soil, water) and biological (tissues, crops) samples, addressing critical gaps in comparative methodologies, a PRISMA-guided systematic. Literature review was conducted across Scopus, PubMed, and Web of Science, analyzing more than 100 peer-reviewed studies (2010–2024) that met the inclusion criteria: English-language publications, multi-index comparisons, and empirical validations. Exclusion criteria removed non-peer-reviewed works and studies focusing on a single …

Mineralocorticoid Receptor Antagonism Of Vamorolone: Evidence From Lionheart And Vision-Dmd Clinical Trials, Ana De Vera, Paula R. Clemens, Utkarsh J. Dang, Catherine Dutreix, Ekaterina Gresko, Michela Guglieri, Laura Hagerty, Shabir Hasham, Jesse Damsker, Yetrib Hathout, Aki Linden, Anders Berglund, Rebecca Tobin, Karim Wahbi, Eric P. Hoffman

Pharmacy Faculty Scholarship

The effect of vamorolone, the first dissociative corticosteroid for Duchenne muscular dystrophy (DMD), at the mineralocorticoid receptor (MR) was investigated in the Phase 1 mechanistic LIONHEART study and using serum samples from boys with DMD in the pivotal VISION-DMD trial. In LIONHEART, 30 healthy adult males were randomized 1:1:1 to vamorolone 20 mg/kg, eplerenone 200 mg, or no treatment arms. A fludrocortisone challenge was administered between –9 h and 24 h after treatment. The LIONHEART primary outcome was urinary Na+/K+ ratio; additional outcomes were pharmacokinetics, urine Na+ and K+ concentrations, and safety. In VISION-DMD, boys with DMD aged 4–7 years …

Reforming Environmental Governance In Response To Indonesia’S Nickel Industrial Policy: A Critical Assessment Of Sustainability Challenges, Farah Rosada

Global: Jurnal Politik Internasional

This study evaluates the effectiveness of Indonesia’s environmental policy reforms in the nickel sector as a response to global criticism regarding ecocidal practices. Indonesia's nickel industry plays a crucial role in the global supply chain, especially in meeting the demand for electric vehicles. However, the ecological impacts of this industry have drawn international scrutiny, particularly from environmental organisations highlighting extensive ecosystem damage. Using environmental security theory, this study focuses on evaluating policy reforms, such as the revision of Environmental Impact Assessments (AMDAL) and the regulation of hazardous and toxic waste (B3), as well as their impacts on ecosystem sustainability and …

Aphasia In South Asian Languages (Asal) Project: A Protocol Of Connected Speech Tasks For Investigating Cross-Linguistic Grammatical Profiles In Aphasia For South Asian Languages, Arpita Bose, Sakshi Bhatia, Lakshmi Venkatesh, Sayantani Banerjee, Gurujegan Murugesan, Sunila John, Sakshi Upadhyay, Manaswita Dutta, Mythili Menon, Danielle Fahey, Multiple Additional Authors

Speech and Hearing Sciences Faculty Publications and Presentations

Background

Languages vary in their syntactic (e.g. word order in sentences), lexical (e.g. presence of specific word classes), and morphological (e.g. inflectional or derivational forms of words) properties. This cross-linguistic variation in language typology influences the manifestation of agrammatic symptoms. However, most theoretical models of agrammatism are based on English and a few European languages, limiting their generalizability. This narrow focus neglects the rich syntactic, lexical and morphological variations available in languages globally. Clinically, the lack of language-specific characteristics of agrammatic impairments limits translational potential for precise and improved diagnosis. The Aphasia in South Asian Languages (ASAL) project addresses this …

Trajectories Of Recovery After Intravenous Propofol Versus Inhaled Volatile Anaesthesia (Thrive) Randomised Controlled Trial In The Usa: A Protocol, Bethany R Tellor Pennington, Laura Swisher, Mara L Bollini, Michael S Avidan, Et Al.

2020-Current year OA Pubs

INTRODUCTION: Millions of patients receive general anaesthesia every year with either propofol total intravenous anaesthesia (TIVA) or inhaled volatile anaesthesia (INVA). It is currently unknown which of these techniques is superior in relation to patient experience, safety and clinical outcomes. The primary aims of this trial are to determine (1) whether patients undergoing (a) major inpatient surgery, (b) minor inpatient surgery or (c) outpatient surgery have a superior quality of recovery after INVA or TIVA and (2) whether TIVA confers no more than a small (0.2%) increased risk of definite intraoperative awareness than INVA.

METHODS AND ANALYSIS: This protocol was …

Coumarin/Nitrogen-Bearing Heterocyclic Hybridloaded Electrospun Pmma/Pvp Nanofibrous Scaffolds For Accelerating Topical Wound Healing Rates: Synthesis And In Vitro Bio-Evaluation, Samar A. Salim, Mohamed Ali, Tasneem Abed, El Badawy Kamoun

Nanotechnology Research Centre

Coumarin-nitrogen heterocyclic compounds (e.g. quinoline, acridine, and phthalazine) were synthesized by facile reactions and elucidated by FTIR, 1H, and 13C-NMR analyses, which showed consistency with the expected structures. Coumarin-quinoline (drug A)- and coumarin-acridine (drug B)-loaded electrospun PMMA/PVP nanofibrous scaffolds were fabricated using electrospinning techniques. Results showed a successful PMMA/PVP blend, which formed the matrix that was used as the main scaffold for drug loading/release. The drugs (A and B) were encapsulated within the matrix as verified by IR and SEM results. Bio-evaluation through cytotoxicity and anticancer screening was conducted using the MTT assay against lung fibroblast (Wi-38), colon carcinoma (Caco-2), …

Development Of A Water Temperature Modeling Platform To Support Short- And Long-Term Water Temperature Management In Reservoir-River Systems, Michael Deas, Yung-Hsin Sun, John Degeorge, Benjamin T. Saenz, Thomas A. Evans, Scott Burdick-Yahya, Stephen Andrews, Jeff Schuyler, William Candy, Lin Zheng, Scott Wells, Multiple Additional Authors

Civil and Environmental Engineering Faculty Publications and Presentations

The U.S. Department of the Interior, Bureau of Reclamation (Reclamation) supports water temperature management for fishery species protection in downstream river reaches below Central Valley Project (CVP) reservoirs in the Sacramento, American, and Stanislaus River systems. The Water Temperature Modeling Platform (WTMP) Project was initiated to modernize and enhance modeling capabilities to predict summer–fall water temperature through reservoir cold water pool management using temperature control facilities designed for temperature management. The WTMP supports forecasts, historical analyses, and long-term planning efforts and advances previous modeling approaches by using an integrated modeling platform. This platform includes a data management system that acquires …

Bees (Hymenoptera: Anthophila) Of Seasonal Herbaceous Wetlands In Mississippi, Haley Hughes, Katherine A. Parys, Kim T. Huntzinger, Caleb Lankford, Christine Fortuin, J. Brian Davis

Publications

Seasonal wetlands help meet the biological needs of various autumn migrating and wintering waterfowl species in North America (Reinecke et al. 1989). Management of seasonally flooded impoundments often uses soil and vegetation disturbances and water management to promote early succession plants that produce abundant seeds for foraging birds (Low and Bellrose 1944, Kross et al. 2008). Native bees (Hymenoptera: Anthophila) also occupy these wetland habitats, as they are attracted to a diversity of flowering plants (Stephenson et al. 2018).

The Mississippi Alluvial Valley (MAV) is an alluvial plain and once represented by nearly 10 million ha of bottomland hardwood forests, …

Pediatric Epilepsy Surgery: The Noninvasive Presurgical Evaluation, Deepankar Mohanty, Michael Quach

Faculty, Staff and Students Publications

Background: Drug-resistant epilepsy is a debilitating condition that afflicts individuals across all demographics, including children. The only recourse for many of these individuals is neurosurgery to reduce seizure burden, by either resecting or ablating the cerebral source or modulating it with a stimulator device. In either case, a thorough presurgical evaluation is required to identify brain regions of interest and construct an appropriate surgical plan. The scope of this evaluation has grown rapidly over the years as new and refined techniques have emerged. The aim of this article was to condense the most salient points regarding investigational tools used commonly …

Efficiency Of Removing A Novel Radiopaque Smear Layer Using Different Activation Instruments, Tyce A. Hebert, Thomas E. Lallier, Dylan C. Mcmahan, Annamari E. Farrar, Albert F. Mcmullen Iii

School of Dentistry Faculty Publications

Introduction: This study quantitively compared the efficiency of removing a novel radiopaque smear layer using different activation instruments. Methods: 60 extracted human mandibular premolars with single canals were decoronated, accessed, instrumented with rotary files to the working length, and radiographed. The root canal was filled with a solution containing insoluble lead salts, in order to impregnate the smear layer, making it radiopaque. All teeth were radiographed to confirm the presence of a radiopaque smear layer. Activation of 6% NaOCl was completed using one of four techniques on 15 teeth each; (1) manual agitation, (2) EndoActivator (EA), (3) SmartLite Pro EndoActivator …

Somatostatin Receptor 2 Overexpression In Hepatocellular Carcinoma: Implications For Cancer Biology And Therapeutic Applications, Servando Hernandez Vargas, Solmaz Aghaamiri, Jack T Adams, Tyler M Bateman, Belkacem Acidi, Sukhen C Ghosh, Vahid Khalaj, Ahmed O Kaseb, Hop S Tran Cao, Majid Momeny, Ali Azhdarinia

The Brown Foundation: Institute of Molecular Medicine

Background: Somatostatin receptor 2 (SSTR2), a G protein-coupled receptor, is overexpressed in multiple malignancies, including hepatocellular carcinoma (HCC). While SSTR2 has traditionally been viewed as an inhibitory receptor involved in suppressing hormone secretion and cell proliferation, emerging evidence suggests a more complex role in cancer biology. However, the functional implications of SSTR2 expression in HCC remain poorly understood. This study aimed to systematically investigate the molecular landscape associated with SSTR2 expression in HCC and evaluate its potential as a therapeutic target.

Methods: SSTR2 expression patterns across 22 tumor types were assessed using TNMplot, and its expression in HCC was further …