Digital Commons Network^™

Alberta Hutterite Colonies: An Exploration Of Past, Present And Future Settlement Patterns, Simon M. Evans

Communal Societies

No abstract provided.

Becoming "Two-In-One:" Imaginary Space And Androgyny In Koreshan Universology, Kathryn Turner

Communal Societies

No abstract provided.

Using Electronic Medical Records To Estimate The Prevalence Of Pediatric Obesity In Mississippi, Brian D. Christman, Abigail Gamble, Sonia Jain, Kalon Kl Ho, Lei Zhang, William B. Hillegass

Journal of Public Health in the Deep South

Background: Pediatric obesity is a major public health concern in Mississippi. However, existing surveillance systems, including the Youth Risk Behavioral Surveillance System, National Survey of Children's Health, and Child and Youth Prevalence of Obesity Survey, are limited by self-reported data, restricted age ranges, and incomplete subgroup coverage.

Purpose: This study evaluates the plausibility of using electronic medical records to improve population-level surveillance of pediatric obesity in Mississippi while addressing issues of data completeness, bias, and representativeness.

Methods: Electronic medical records from 40,215 patients aged 2–19 years who received care at the University of Mississippi Medical Center (2013–2022) were analyzed via …

Enhancing Public Health Strategies: Addressing The Rsv Burden In Alabama Through Clinical Treatment, Community Prevention, And Surveillance Approaches, Martha K. Findley Roper, Jennifer S. Dawson

Journal of Public Health in the Deep South

Introduction: Respiratory Syncytial Virus (RSV) is a highly contagious pathogen driving morbidity, hospitalizations, and economic burden. This review uses the epidemiological triad and National Wastewater Surveillance System data to assess transmission, viral load spikes in Alabama, and strategies for treatment and prevention.

Methods: A review of literature on supportive care, vaccination, monoclonal antibodies, and emerging nanomedicine was reviewed to evaluate strategies for reducing viral burden and complications.

Results: Trends from December 2024–January 2025 were assessed with National Wastewater Surveillance System data. Primary prevention includes immunization, hygiene, air quality maintenance, and early diagnostics. Tertiary care addresses complications such as secondary …

Trends In Drug Overdose Deaths In Alabama, 2010-2020, Michael Rutalira Koko, Raphu Wakumeki

Journal of Public Health in the Deep South

Background: Drug overdose deaths are the leading cause of injury-related death in the United States. Over the past two decades, drug overdose deaths have dramatically increased in the United States, and the rise in the number of drug overdose deaths is mostly due to opioids. This descriptive study aimed to examine trends in drug overdose deaths according to age, sex, and race/ethnicity from 2010 to 2020 in Alabama.

Methods: We used data from the National Vital Statistics System (NVSS) and the U.S. Census Bureau to calculate age-adjusted mortality rates for specific age groups, gender, and race/ethnicity. We used SAS Version …

3d Modeling Of Brain Removal With Cranial Nerve Preservation, Lauren Blank, Sophia Cox, Avery Preston

Student Scholar Symposium

3D Modeling of Brain Removal with Cranial Nerve Preservation Abstract: Visual- spatial skills are essential in learning anatomy as they allow students to mentally visualize and manipulate the three-dimensional structure of the human body. Traditional dissectors like Grant’s Dissector typically provide only 2D images to guide brain removal. These manuals often do not include the occipital wedge approach, which favors cranial nerve preservation during brain dissection. A 3D model that assists students in learning a non-traditional dissection approach through manipulating a brain model will help improve mental rotation skills, especially benefiting those with weaker spatial abilities. In collaboration with Lipscomb …

Analysis Of Solutions To Research Methods: Navigating The Infinite Content Of Mathematics, Jesus Navarro

Student Scholar Symposium

In the infinite realm of mathematical research, understanding and communicating complex concepts require structured and logical approaches. However, a variety of research methods are employed in mathematical studies; these may differ in approach, historical context, and other important considerations which can contribute to confusion and a lack of effective communication. The genesis of this research began with personal confusion during my research on "Counting the Uncountable: Life in a World Without Numbers", setting the stage for the central challenge: How do mathematicians explain their research? To answer this issue, we analyzed a variety of mathematical research articles to highlight their …

Bcl-2 Regulation As Seen In Alzheimer's Disease, Whitley Whitehead, Joseph Marek, Jack Lowry, Parker Shirley

Student Scholar Symposium

Alzheimer’s Disease (AD) is a degenerative and destructive disorder causing progressive impairment and loss of the nerve cells, eventually leading to further impairments of cognitive functions. Calcium ions (Ca2+) are vital for cell signaling and muscle contraction. The Bcl-2 protein family helps regulate cell death by controlling the release of Ca2+ from the ER. Bcl-2 can also block pro-apoptotic proteins from puncturing the mitochondria and causing intrinsic apoptosis. In AD, the presence of amyloid-beta plaques and neurofibrillary tangles downregulates Bcl-2 production. The loss of Bcl-2 leads to mitochondrial damage, heightened calcium levels, and oxidative stress. Although there is no cure …

Elucidating The Role Of Hd5 In Colonic Wound Healing, Lavin Radiro

Student Scholar Symposium

Crohn’s colitis (CC), a subtype of inflammatory bowel disease (IBD), causes chronic inflammation in the large intestine, leading to malnutrition, diarrhea, and severe pain. Early and accurate diagnosis of CC is crucial, as misdiagnosis with ulcerative colitis (UC) can result in inappropriate treatment and worsened outcomes. The innate immune peptide human alpha-defensin 5 (HD5) is upregulated in CC but not in UC, suggesting a potential role in disease pathogenesis. Preliminary data from our lab indicates that HD5 impairs wound healing in colonic epithelial cells, but the molecular mechanisms remain unclear.

Hypothesis We hypothesize that HD5 increases RNA and protein levels …

Investigating The Potential Ability Of The Tlr4-Nf-Κb Axis To Reduce Aryl Hydrocarbon Receptor Expression In Intestinal Epithelial Cells, Gabriella Longoria

Student Scholar Symposium

Necrotizing enterocolitis (NEC) primarily affects premature infants and is characterized by intestinal necrosis, inflammation, and high mortality. Toll-like receptor 4 (TLR4)-induced apoptosis of intestinal epithelial cells is thought to drive NEC development. Upon binding bacterial lipopolysaccharide (LPS), TLR4 signaling activates NF-κB, leading to inflammatory gene expression. Indole-3-carbinol (I3C), a pro-ligand of the aryl hydrocarbon receptor (AhR), prevents NEC in a mouse model by downregulating TLR4, despite reduced AhR expression in NEC-affected intestines. However, the molecular mechanism behind the reduced expression of AhR in NEC is unclear. To model NEC in vitro, we treated IEC-6 enterocytes with LPS, which reduces AhR …

Investigating The Role And Mechanism Of Faecalibacterium Prausnitzii In Fatty Acid Metabolism And Obesity Using The Drosophila Melanogaster Model, Jackson Head, Whitley Whitehead

Student Scholar Symposium

The obesity epidemic has increased to enormous numbers with 890 million adults being classified as obese (BMI≥30). Obesity is of extreme concern as it is a comorbidity to coronary heart disease, type-2 diabetes, and cancer. Although obesity has classically been attributed to genetics and lifestyle, there is a growing interest in other factors, including the gut microbiome. Germ-free mice are resistant to weight gain even when placed on a high-calorie diet, establishing that metabolites produced by gut microbiota can dramatically inhibit metabolism. Here, we use Faecalibacterium prausnitzii, which has been previously shown to be reduced in obese individuals; however, …

Indole Improves Outcomes Of Cronobacter Sakazakii Infection In C. Elegans Through Ahr-1, Cayden Durrough

Student Scholar Symposium

Necrotizing enterocolitis (NEC) is a severe gastrointestinal disease primarily affecting premature infants. Toll-like receptor 4 (TLR4)-mediated epithelial damage allows microbial translocation, triggering inflammation that can lead to sepsis and death. The aryl hydrocarbon receptor (AhR) is a ligand-dependent transcription factor, and AhR ligands have been shown to prevent NEC in a mouse model. Indole, an AhR ligand, has been reported to extend the healthspan of C. elegans, and we have shown previously it mitigates poor outcomes in wild-type worms infected with Cronobacter sakazakii (Cs), a bacterial pathogen linked to NEC. We hypothesized that C. elegans must express ahr-1, the ortholog …

Indole Treatment Of C. Elegans Rescues Cronobacter Sakazakii Induced Illness, Joshua Asselin

Student Scholar Symposium

Necrotizing enterocolitis (NEC) is a severe and often life-threatening inflammatory condition of the intestine primarily affecting premature infants. The opportunistic pathogen Cronobacter sakazakii (Cs) has been implicated in NEC. While activation of the ligand-dependent transcription factor aryl hydrocarbon receptor (AhR) has been shown to prevent NEC in a mouse model, its potential as a therapeutic target for established NEC remains unclear. We hypothesize here that the AhR ligand indole can reverse Cs-mediated illness in the model organism Caenorhabditis elegans. Our results demonstrate that exposure to live Cs, but not heat-killed Cs, significantly impaired worm motility, demonstrating Cs is an effective …

Exploring The Functional Role Of Neprilysin In Pi3k/Akt1 Signaling In Triple-Negative Breast Cancer, Ariadna Daniela Menjivar

Student Scholar Symposium

Our lab is investigating the protein Neprilysin (NEP) and its role in Triple-Negative Breast Cancer (TNBC). Previous bioinformatics data from Dr. Conway’s research indicated that in TNBC cells high in Neprilysin expression (HCC38), the PI3K pathway was the most active signaling pathway. This information suggests that Neprilysin is positively upregulating the PI3K pathway in this cell line. This is interesting given the fact that in the context of TNBC, Neprilysin has been shown to negatively regulate the PI3K/AKT signaling pathway. The PI3K/AKT pathway is the most commonly mutated pathway in breast cancer. AKT is the central mediator protein in this …

Levels Of Beta Catenin With Treatment Of Hd5 In Iec-6 Rat Cells, Audrey Birdwell, Josiah Stafford, Obaid Ashari, Emily Powell, Maryam Gerges, Maryam Mina

Student Scholar Symposium

Human Defensin 5 (HD5) is an antimicrobial peptide present in the small intestine that plays a role in gut homeostasis. We have been investigating the role of HD5 in colon cells, but research shows that HD5 levels in the small and large intestine vary significantly in Crohn's. Previous data from our lab suggests that HD5 leads to a decrease in wound healing and an increase in apoptosis in colon cells, we want to see if the same is true in the small intestine. So, we are investigating the effect of HD5 on expression of β-catenin, a key protein in the …

6ppd-Quinone In Middle Tennessee Waters: Assessing Ecological Impact, Andrew Davis Todd, Raphael Marquise Chandler, Kerolos Gerges Basalos, Denise Lori Loewinger

Student Scholar Symposium

This poster presents the dangers of a toxic chemical used on car tires that is entering aquatic ecosystems and harming fish populations.

Will This Too Pass? How The Criminalization And Derogation Of Unhoused People Is One Mark Of Our Descent Into Fascism, Michaela R. Martin Strout

Vanderbilt Social Justice Reporter

No abstract provided.

Function Of Drosophila Melanogaster Domesticated Transposable Element Protein Dplg3 In Oogenesis And Total Fitness, Aron Herrera

2025 Fall Honors Capstones Projects - Archive

Transposable elements (TEs) are selfish DNA segments capable of self-replication and reinsertion within genomes, often harming hosts. Rarely, host genomes can adopt TEs and use their proteins for new cellular functions through molecular domestication. One example primarily expressed in Drosophila melanogaster ovaries is DPLG3. Previous Betrán Lab students generated DPLG3 loss-of-function flies and found that their ovaries misregulated one primordial and 14 testis-specific genes, leading to variable ovarian malformations. However, it is unclear when during oogenesis these misexpressions occur. We will extract RNA from non-rudimentary ovaries at early and late stages to generate cDNA for qRT-PCR analysis of three …

Understanding Florida's Hb 1105: What Parents Need To Know About The End Of Special Education Certificates Of Completion, Noelle Mercer, Valerie Sheehe, Joshua Wilkenson

Gator Team Child Juvenile Law Clinic

The goal of this white paper is to explain the implications of HB 1105 for students with disabilities and their families. It outlines the background of Florida’s previous graduation framework, describes the new diploma options now available, and explores both the potential benefits and challenges of this transition. Finally, it provides practical guidance for parents, including steps to take within Individualized Education Plan (IEP) meetings, questions to ask school administrators, and community resources that can assist families navigating this change.

Impact Of Gas Supersaturation On The Development Of Gas Bubble Trauma In Paedomorphic Eurycea Salamanders, Trent Furr

Biology Theses

There are eleven species of paedomorphic lungless salamanders endemic to Texas. Of these, eight are considered threatened by the International Union for Conservation of Nature (IUCN). One of these, the Barton Springs Salamander (Eurycea sosorum), is found only in springs and aquifers in and around Austin, Texas. A large population of this species is found in Barton Springs, located in Austin, TX–where dissolved gas saturation has been measured as high as 134%. Morbidity and mortality events in Barton Springs Salamanders have been documented coinciding with periods of dissolved gas supersaturation. This study seeks to understand what environmental conditions lead to …

Quantifying Dna Groove Binding Dynamics Of Netropsin Using Optical Tweezers, Jacob Mcnally

Honors Program Theses and Projects

Netropsin is a small molecule that binds to the minor groove of DNA and serves as a model scaffold for DNA-minor groove binding anticancer drugs. Understanding how Netropsin interacts with DNA under mechanical stress is important for characterizing how similar molecules function in biological environments. In this work, we used dual-beam optical tweezers to study how Netropsin binding affects the mechanical behavior of single DNA molecules under applied force. Individual DNA molecules were held under controlled forces while Netropsin was introduced at varying concentrations. Constant-force measurements were used to probe binding dynamics; however, we found binding occurred too rapidly to …

Viral Warriors: Unlocking The Immune System’S Potential With Oncolytic Viruses In Cancer Immunotherapy, Reza Ghavimi, Leila Rahimian, Mohsen Mohammadi, Ojasvi Dutta, Harikrishnan Mohan, Vladimir Chouljenko, Tolulope O. Omolekan, Jean Christopher Chamcheu, Konstantin G. Kousoulas

Faculty Publications

Oncolytic viruses (OVs) represent an exciting avenue in tumor immunotherapy, harnessing the power of viruses to overcome resistance and enhance immune responses. OVs achieve this by selectively targeting and destroying tumor cells. This cell lysis releases tumor-specific antigens (TAAs), effectively creating an in situ vaccine that educates the immune system. Moreover, OVs directly trigger both innate and adaptive immunity and can be genetically engineered to secrete immune-boosting factors. Early studies have shown promising synergistic antitumor effects when OVs are combined with other cancer therapies or immunotherapies. A key advantage of OVs is their capacity to reprogram the tumor microenvironment (TME), …

Preparing Students For College And Careers: Recommendations For Scaling College And Career Pathways In Southwestern Illinois, Laura Monteagudo

Reports, Analyses, and other Publications

Education Systems Center (EdSystems) at Northern Illinois University provided strategic counsel and support to Southwestern Illinois College (SWIC) for a 12-month period to develop comprehensive college and career pathways. Our support included the development of a unified, regionwide college and career pathway system aligned with Illinois’ College and Career Pathway Endorsement framework, Perkins V, and the State of Illinois Model Programs of Study Guides.

Instead of each district building pathways independently, this regional approach brings together high schools, community college faculty, and local employers to create shared structures that reflect real workforce needs and rural access challenges.

In this report, …

Assessing River Herring Habitat After Aquatic Herbicide (Fluridone) Application, Caroline Reusch

Master’s Theses and Projects

No abstract provided.

Cotton Town Blues: An Investigation Of Social Inequality, Diet, And Health In A 19th Century Industrializing Population—St Peter’S Churchyard, Blackburn, Lancashire, Andy Barlow, Catriona Pickard, Linda Fibiger, Kerry L. Sayle, Sarah Schaeffer, Emma Smith, Julie Franklin, Brooke Carter, Lea Perrino, Clive Bonsall

Human Biology Open Access Pre-Prints

Historical accounts document that the shift from rural settlement to urban settings and from employment in cottage industries to factory working at the turn of the 19th century had a negative impact on the lower classes.

In 2015, the relocation of the cemetery of St Peter’s Churchyard in Blackburn, Lancashire, provided an opportunity to study the effects of industrialization on the diets and health of an early to mid-19th-century population through osteological and biomolecular analyses. Those interred at St Peter’s represent a socioeconomic cross-section of the church’s parishioners. In this paper, we present an evaluation of the lifetime dietary biographies …

Taking Back The Trades: Southwestern Illinois Work-Based Learning Inventory Report, Alexia Santiago

Reports, Analyses, and other Publications

In 2025, Education Systems Center at Northern Illinois University (EdSystems) partnered with Southwestern Illinois College (SWIC), regional school districts, and industry partners to build a strong and comprehensive system of work-based learning opportunities for K-12 students that is aligned with Illinois statutes and frameworks. In this report, EdSystems identifies the existing regional events and activities that promote high-quality work-based learning for college and career pathways in the health sciences and manufacturing sectors.

Clemson Commencement Program, December 2025, Clemson University

Clemson Commencement Programs

No abstract provided.

The Other Side Of The Wall: A Study On The Impact Of Paternal Incarceration On African American Children, Chance M. Wideman

Electronic Theses and Dissertations

This qualitative dissertation explores the long-term psychological, relational, and systemic impacts of paternal incarceration on adult children. Guided by Adverse Childhood Experiences (ACE) Theory, Attachment Theory, and Family Process Theory, this study examines two research questions:

(1) What types of childhood trauma are associated with paternal incarceration?

(2) How does the childhood trauma associated with paternal incarceration impact one in adulthood?

The study draws on three in-depth narrative interviews with adults who experienced paternal incarceration in childhood. These interviews, framed as dialogic and reflexive spaces, illuminate the deep and layered consequences of incarceration across the lifespan.

Five central findings emerged: …

Ole Miss Student Joins Elite Cohort Of Newman Civic Fellows, Marisa C. Atkinson

University of Mississippi News

OXFORD, Miss. – University of Mississippi junior Emerson Morris takes pride in her community and home state, and she hopes to channel her passion to one day advocate for underserved regions of the South.

Exploring The Individual Relationships Of Mothers' And Fathers' Parenting Styles With Emerging Adults' First-Term Gpa, Tiffany Fox Okeke

Theses and Dissertations

Parenting styles have most often been studied through the lens of adolescent academic outcomes but less is known about how mothers' and fathers' parenting styles influence academic performance separately, especially during the critical transitionary period to post-secondary education. This study examines how mothers' and fathers' parenting styles distinctly shape emerging adults' first-term academic outcomes during their postsecondary education, with a focus on the dimensions of parental warmth and control. The study uses the National Longitudinal Survey of Youth 1997 dataset and the NLSY97 Post-Secondary Transcript Data focusing on the 1997-2005 cohorts (N=3,478) along with OLS regression analyses to predict emerging …