Digital Commons Network^™

Identification Of Critical Brain Regions For Autism Diagnosis From Fmri Data Using Explainable Ai: An Observational Analysis Of The Abide Dataset, Suryansh Vidya, Kush Gupta, Amir Aly, Andy Wills, Emmanuel Ifeachor, Rohit Shankar

School of Engineering, Computing and Mathematics

BACKGROUND: Diagnosis of autism spectrum disorder (ASD) significantly improves quality of life, yet current diagnostic practices rely on subjective behavioural assessments. While machine learning models using functional Magnetic Resonance Imaging (fMRI) show promise for objective diagnosis, existing approaches have critical limitations. High-accuracy models often neglect interpretability, increasing clinical distrust, while interpretable approaches frequently suffer from low accuracy and lack neuroscientific validation of identified biomarkers. Furthermore, no studies have systematically benchmarked which interpretability methods are most effective for fMRI data, hindering the translation of Artificial intelligence (AI) findings into clinical practice.

METHODS: In this observational study, we used the Autism Brain …

Synthesis And Optical Properties Of Unsymmetric Aromatically Π-Extended Bodipy, Metodej Dvoracek, Craig Newman, Mikhail Drobizhev, Brendan Twamley, Mathias O. Senge, Sergei A. Vinogradov, Mikhail A. Filatov

Research Outputs: 2025-Present

A series of unsymmetrically substituted BODIPY dyes featuring fused benzo- or naphtho-fragments on one pyrrolic unit were synthesized from the corresponding pyrrolic precursors. The synthetic route was optimized using a modular approach based on the condensation of formylpyrroles with alkylpyrroles, enabling the identification of precursor combinations that minimize byproduct formation and improve preparative yields. The resulting benzo- and naphtho-fused BODIPYs display intense fluorescence in the red region, with emission maxima spanning 590–680 nm and fluorescence quantum yields ranging from 0.27 to 0.84. Their two-photon absorption (2PA) properties were studied both experimentally and computationally. An increase in the two-photon absorption cross-section …

Injury To Soybean Seedlings From Alfalfa Weevil (Coleoptera: Curculionidae) Larvae, Robert L. Koch, M. Lourdes Chamorro

The Great Lakes Entomologist

Alfalfa weevil, Hypera postica (Gyllenhal) (Coleoptera: Curculionidae), is primarily a pest of alfalfa, but it has been reported feeding on other plants, including soybean. The relatively limited literature on H. postica in soybean indicates that adults and larvae can feed on soybean, but it is not suitable for larval development and survival. There have been instances of H. postica adults moving from alfalfa to nearby soybean fields where they have inflicted significant injury to the soybean plants. Here we report an instance of H. postica larvae causing severe feeding injury to soybean. This infestation of soybean was the result of …

Variability In Arthropod Community Surveys: Observations Of Ground-Dwelling Arthropods Are Dependent On Methodological Choices, Katherine Mcnamara Manning, Kayla I. Perry, Christie A. Bahlai

The Great Lakes Entomologist

Sampling approaches are commonly adapted to reflect the study objectives in biodiversity monitoring projects. This approach optimizes findings to be locally relevant but comes at the cost of generalizability of findings. Here, we detail a comparison study directly examining how researchers’ choice of arthropod trap and level of specimen identification affects observations made in small-scale arthropod biodiversity studies. Four arthropod traps (pitfall traps, yellow ramp traps, yellow sticky cards, and novel jar ramp traps) were compared with respect to an array of biodiversity metrics calculated at two levels of identification. The arthropod community captured varied by trap type. Pitfalls and …

Pollen Loads Of Insects Caught In Cultivated Fields Of Oilseed Pennycress, Frank Forcella, Ellinor Sheik, Michael Zavada, Mark Bernards

The Great Lakes Entomologist

Although many insects are known to be associated with the floral canopies of oilseed pennycress (Thlaspi arvense), those that carry the crop’s pollen are unknown. During early spring of 2024 insects associated with pennycress flowers in Illinois and Minnesota were captured in sweep nets, frozen, sorted by species, and sonicated to remove pollen. Pollen grains were counted, and pollen loads per individual insect were calculated. Members of the orders Diptera, Hemiptera, and Hymenoptera accounted for 66%, 16%, and 14% of the 850 insects examined, but these same orders were responsible, respectively, for 18%, 3%, and 78% of the …

Nest Pollen Provisions From An Urban Population Of Megachile Campanulae (Hymenoptera: Megachilidae) In Minnesota Are Consistent With Oligolectic Classification., Lam D. Le, Thea A. Evans, Colleen Satyshur

The Great Lakes Entomologist

The conservation of bees is crucial for maintaining the essential ecological services they provide. Understanding bee species' risk of extinction is a key part of conservation efforts, and can include assessment of dietary specialization, which has been linked to higher extinction risk. Dietary specialization in bees, called oligolecty, occurs when females select pollen only from closely related plants to feed their larvae. While the solitary bee, Megachile (Chelostomoides) campanulae (Robertson 1903), has been associated with flowers in the genus Campanula L. (Campanulaceae: Asterales), evidence from pollen analysis is limited, and dietary classification is reported inconsistently. This study examined dietary specialization …

Nocturnal Flight Periodicity Of Caddisflies (Trichoptera) Along The Lake Huron Shoreline Of Drummond Island, Michigan (Usa), Robert A. Haack, David Houghton

The Great Lakes Entomologist

Over 7000 caddisfly specimens, representing 33 species in 10 families, were collected between sunset and sunrise on 12 nights: three nights each during early July and early August in both 2023 and 2024. Collections were made on the southwestern side of Drummond Island along the shoreline of Lake Huron. Sampling occurred for five minutes at 15-minute intervals from near sunset (21:00) to 01:00 and then once again at 03:00 and 05:00. Nocturnal flight periodicity was broadly similar between years and months, with mean caddisfly abundance and species richness peaking at about one hour after sunset. Mean species accumulation varied between …

Initial Changes In Ground Beetle (Carabidae: Coleoptera) Assemblages After Creating Gaps Of Varying Sizes In Mature Northern Hardwoods Forests In Wisconsin, Robert A. Haack, Robert E. Acciavatti, Toby R. Petrice, Robert L. Davidson, Terry F. Strong

The Great Lakes Entomologist

Managers of northern hardwood forests in the Great Lakes region create gaps in the forest canopy of various sizes during harvesting to achieve different silvicultural objectives. Single-tree harvesting favors recruitment of shade-tolerant tree species by creating small gaps in the canopy, whereas group selection creates larger gaps that can favor shade-intolerant tree species. We evaluated changes in carabid beetle abundance and diversity in harvest-created gaps of five sizes (gap diameters of 6, 10, 20, 30, and 46 m) and uncut forests in northern Wisconsin where sugar maple (Acer saccharum) was the dominant tree species. Gaps were cut during …

Cover Pages For Tgle Vol. 58 Nos 1 & 2

The Great Lakes Entomologist

Cover Pages for TGLE Vol. 58 Nos 1 & 2

A Day In The Life Of An Orbital And Oculoplastic Surgeon, Alexis Duffy, Ba

inSIGHT

Have you ever heard of an oculoplastic surgeon before? And if so, ever wonder what they do or how they differ from plastic surgeons? Treating the periocular region requires an in-depth understanding not only of the eye, but also its complex interplay with adjacent orbital, sinus, and craniofacial anatomy; there is much more than meets the eye! The most common pathway to become an oculoplastic surgeon includes completion of a four-year ophthalmology residency, followed by one to two years of subspecialized oculoplastic fellowship. Oculoplastic fellowships provide surgical and medical experience managing pathology of the eyelid and orbit, and different programs …

Miconazole Induces Cell Cycle Arrest And Apoptosis In Prostate Cancer Cells Via A P53-Mediated Pathway: A Drug Repurposing Strategy, Eswara Naga Hanuma Kumar Ghali, Lindsey Shim, Rahul Tiwari, Rajasekhar Baru, Anupam Dhasmana, Ryan Chang, Sung Yun Jung, Vivek K. Kashyap, Neeraj Chauhan, Subhash Chauhan, Murali Yallapu

Research Colloquium

Aim: Repurposing of FDA-approved antifungal drugs to combat prostate cancer.

Background: Prostate cancer is one of the leading causes of cancer death among men in the United States, second only to non-melanoma skin cancer. The American Cancer Society estimates about 313,780 new cases and 35,770 deaths from prostate cancer in 2025. Despite various treatments such as radiation therapy (both external beam and internal), chemotherapy, hormone therapy, cryotherapy, biological therapy, and high-intensity focused ultrasound, men are monitored for side effects over many years. Therefore, new drugs and treatment strategies are urgently needed to address this challenge.

Methods: In this study, we …

Hfd Feeding For Seven Months Abolishes Sting Disruption-Driven But Not Female Sex-Based Protection Against Hepatic Steatosis And Inflammation In Mice, Xinlei Guo, Honggui Li, Bilian Zhu, Xiaoxiao Wang, Qian Xu, Eduardo A. Aquino, Minji Koo, Qingsheng Li, James Cai, Shannon Glaser, Chaodong Wu

Research Colloquium

Stimulator of interferon genes (STING) is positively correlated with the degrees of liver inflammation in human metabolic dysfunction-associated steatotic liver disease (MASLD). In addition, STING disruption alleviates MASLD in mice fed a high-fat diet (HFD) for 3 months (3- m-HFD). Here we investigated the role of the duration of dietary feeding in regulating MASLD in mice and explored the involvement of STING in sex differences in MASLD. Both male and female STING-disrupted (STINGgt) and wild-type C57BL/6J mice were fed an HFD for 3 or 7 months (7-m-HFD). Additionally, female STINGgt mice upon ovariectomy (OVX) and 3-m-HFD were analyzed for MASLD. …

Generation Of Functional Hepatocytes From Human Induced Pluripotent Stem Cells, Daniela Gonzalez, Miriam Aceves, Lorena Guerra, Jose C. Granados, Felicia Juarez, Earl Novilla, Ana C. Leandro, Marcelo Leandro, Joanne E. Curran, John Blangero, Sarah Williams-Blangero, Satish Kumar

Research Colloquium

Background: One of the most common forms of chronic liver disease is nonalcoholic fatty liver disease (NAFLD). NAFLD is a condition of hepatic steatosis, excess fat accumulation in hepatocytes. It affects about 38% adults worldwide and about 50% adults in the Rio Grande Valley, and is a major risk factor for more serious nonalcoholic steatohepatitis (NASH), liver cirrhosis, and hepatocellular carcinoma (HCC). The risk for NAFLD is likely due to a complex interplay of genetic and environmental factors. Other metabolic diseases, such as obesity and type 2 diabetes, that have a high prevalence in the Valley, likely contribute to …

From Venom To Medicine: Harnessing Animal Toxins For Drug Discovery, Christine Vega, Ying Jia

Research Colloquium

Background: Drug development research has long focused on synthesizing novel therapeutics while overlooking isolation from naturally available sources such as animal venoms. Recently, the discovery of the therapeutic effects of highly bioavailable animal venom caused the field of venom research to soar in popularity. Animal venom serves as a natural, sophisticated tool optimized over millions of years by evolution with the ability to bind to ion channels such as nAChRs, non-specific ligand-gated ion channels distributed throughout the human nervous system. However, purifying individual venom toxins from crude venom is challenging due to its availability. Therefore, synthesizing large quantities of venom …

The South Texas Center Of Excellence In Cancer Research Core Facilities, Bianca Jimenez, Joel De Los Santos, Lindsey Shim, Iris Enriquez, Subhash Chauhan, Murali Yallapu

Research Colloquium

Background: The University of Texas Rio Grande Valley-School of Medicine (UTRGV-SOM) has founded the South Texas Centre of Excellence in Cancer Research to address disproportionate cancer related health issues in the Valley. UTRGV-SOM established an Integrated Cancer Research Core (ICRC, CPRIT/UT System), Drug Delivery and Nanomedicine Core (DDNC, CPRIT), and Research Capacity (RCMI) Facilities at the UTRGV campus to provide cutting-edge technologies to support cancer research investigators of the Rio Grande Valley. The ICRC will house technologies like Flow Cytometry, CyTOF, Image Stream Flow, Droplet Digital PCR, molecular and microPET/CT imaging. Our expertise and focus on this presentation will be …

The Intersection Of Obesity And Breast Cancer In South Texas: Clinical Implications And Regional Disparities, Aura M. C. Calderon, Ivan Mogollon, Luis Salcedo, Jose Loayza, Diane Nguyen

Research Colloquium

Introduction: Breast cancer continues to be the most frequently identified malignancy among females in both Texas and the broader United States. Although South Texas presents a marginally diminished incidence rate overall, the area persists in confronting significant disparities in terms of disease burden and health outcomes. These discrepancies are particularly pronounced among Hispanic women residing in the Rio Grande Valley (RGV), who encounter heightened probabilities of receiving diagnoses at advanced stages despite a lower general incidence rate. Structural inequities, such as restricted access to healthcare services, socioeconomic deprivation, and inadequate health literacy, interact with obesity-associated biological risk factors, thereby engendering …

Evolutionary Conservation And The Role Of Foxp2 In Human Speech And Language Development, Keira N. Ballard

OneUSF Undergraduate Research Conference

The study of genes offers a crucial understanding in the evolution of species and the many abilities an organism may have, including language. The FOXP2 gene encodes for the protein forkhead box P2, a transcription factor that is active in the development of speech and language during embryogenesis. Several single-nucleotide polymorphisms of this gene in humans have been linked to the speech and language disorder, childhood apraxia of speech, further supporting the gene’s role in human speech and language. The FOXP2 gene is highly conserved across vertebrates, even in species with limited vocalizations. This is particularly true among humans, chimpanzees, …

Insights On Aapeptides As They Relate To Inhibiting The P300 Ch1 Domain, Tyler Lambert

OneUSF Undergraduate Research Conference

The HIF-1 pathway helps sustain cancerous tumors by preventing tumor cells from becoming necrotic. The histone acetyltransferase p300 protein is a vital coactivator used in the HIF-1 (hypoxia inducible factor) pathway by binding to subunit HIF-1a. Within our lab we aim to use novel AApeptides as a means of competitively inhibiting the p300 coactivator from binding to the HIF-1a subunit. In order to do this we are specifically studying the protein protein interactions of the CH1 (cysteine/histidine rich-1) domain of the p300 protein as it binds to the C-terminal transactivation domain of the HIF-1a subunit. The p300 CH1 domain is …

Exploring Marine Microbial Products: Targeting Medical Bacteria In Little Bayou Bay, Shivam Anil Patel

OneUSF Undergraduate Research Conference

This study focuses on the identification and curation of microbial natural products, with a specific interest in their potential to target medical-related bacteria. The environment of the Little Bayou Bay was sandy with dirt near alley water that goes out to the Little Bayou Bay. The depth of sample was collected can have different pH level, and bacteria that live in the area. Understanding these reasons why microbial natural target medical-related bacteria can open numerous treatment options. The goal of the research lab is to isolate a bacterium from a sample from Little Bayou Bay. During the lab conduct multiple …

Comparison Between Aunp And Tio2np Nanocarriers For The Treatment Of Chronic Obstructive Pulmonary Disease, Andrew Thomas, Vedant Patel, Rohit Borra, Joy Yang

OneUSF Undergraduate Research Conference

Chronic Obstructive Pulmonary Disease (COPD) is one of the most fatal diseases in the world, leading to lung tissue damage and persistent inflammation. Patients with COPD are typically treated with a bronchodilator and steroids to alleviate bronchoconstriction and inflammation; however, the steroids have limited effects. Inhaled nanomedicine utilizes small agents that facilitate pulmonary-targeted delivery, which improves the absorption and potency of the medication. Over a century ago, Paul Ehrlich proposed the 'magic bullet' theory—targeting diseases precisely while minimizing side effects. Recently, nanomedicine has emerged to support Ehrlich’s theory by fostering nanoparticle drug delivery systems, such as gold (AuNPs) and titanium …

Srgap2c And The Human Mind: A Genetic Key To Cognitive Evolution, Alexis J. Zayas

OneUSF Undergraduate Research Conference

The SLIT-ROBO Rho GTPase Activating Protein 2C (SRGAP2C) gene is a human-specific ortholog of murine SRGAP2 and paralog of SRGAP2A, playing a pivotal role in cortical development and neural plasticity. Unlike SRGAP2A, SRGAP2C arose through segmental duplications unique to the Homo lineage approximately 3.4, 2.1, and 1 million years ago. These duplication events coincide with the divergence of early Homo species from Australopithecus and the emergence of increased cognitive abilities and tool use. SRGAP2C functions as a dominant-negative regulator of SRGAP2A by inhibiting its activity. This results in delayed synaptic maturation and increased density of dendritic spines, key factors thought …

Evolutionary Optimization Of Biologically-Inspired Mechanistic Input-Output Neural Circuit Models In The Auditory Pathway, Abdul-Malik Zekri

OneUSF Undergraduate Research Conference

Understanding how to compute specific functions from neural architecture is a fundamental challenge in neuroscience, with profound implications for artificial intelligence, neuromorphic computing, and neurological health. This study employs evolutionary meta-heuristic algorithms to optimize a mechanistic input-output spiking neural network (SNN) model of the cochlear nucleus, a key circuit in the auditory pathway. The research integrates biologically inspired initialization, iterative optimization, and data-driven validation to explore how connectivity and topology influence input-output relationships in neural circuits. Synthetic input-output spike train pairs for spiral ganglion and bushy cells are generated using a computational model of the cochlear nucleus. SNNs are initialized …

Reverberations Of The 1950s Puerto Rico Nationalist Independence Movement, Gustavo Alonso Chamu

History in the Making

In the first half of the twentieth century, the nationalist movement in Puerto Rico, led by Harvard Law School graduate Pedro Albizu Campos (1893–1965), firmly called for the independence of the island. Its supporters made vociferous calls against the exploitation of the island by the United States government, its military and multinational corporations. Their campaign for independence culminated on October 30, 1950, with small-scale armed insurgencies across Puerto Rico, the Governor’s residence in San Juan, and the attacks against then President Harry S. Truman (1884–1972) at Blair House, Washington D.C. While a combination of domestic and foreign actors played significant …

The Black Curse: The Curse Of Ham And The Mark Of Cain As Justification For Black Subjugation, Margaret Phillips

History in the Making

The concept of race, particularly the construction of blackness and anti-blackness, emerged during the Medieval and Early Modern periods around the Mediterranean and its surrounding cultures. It is a concept of religious origin, in that it first depended on the worldview of the Abrahamic faiths—Judaism, Christianity, and Islam— and their interpretations of the narratives surrounding the Biblical figures Cain and Ham. This established the “mark” of black skin as a curse placed by the Abrahamic God that made up the foundational justifications for racial hierarchies and the subjugation of black Africans. The convenient narrative framed blackness as inherently inferior and …

Ethical Issues Involved In Solid Organ Xenotransplantation., Daniel J Hurst, Chris Bobier, Luz A Padilla

Rowan-Virtua School of Osteopathic Medicine Departmental Research

Xenotransplantation (specifically, genetically modified pig-to-human transplant of organs, tissues, or cells) clinical trials are set to begin in the United States after decades of pre-clinical studies and recent decedent and compassionate use investigations. This article provides a primer on the key ethical issues attendant with this emerging therapy. We explore four central areas of concern: (i) the use of animals to meet human transplant needs, as well as their welfare since they are housed in non-natural conditions, (ii) the risk of infectious disease transfer from the porcine graft to the human recipient, known as xenozoonosis, (iii) patient selection criteria for …

The Indiana Statesman, September 18, 2025, Indiana State University

Student Newspaper

Indiana State sued by American Civil Liberties Union; Campus mourns passing of Kaylynn Lucas

Α-Amylase-Mediated Antibiotic Degradation And Sequestration In Pseudomonas Aeruginosa Biofilm Therapy, Robert K. Murray, Allison E. Martin, Sarah Zipkowitz, Nusrat Jahan, Tony D. Davis, Whitni K. Redman

Pharmacy Faculty Scholarship

Background: As of 2022, 80% of all documented microbial infections are biofilm-associated: communities of microorganisms adhered to a surface and enclosed in a complex extracellular polymeric substance (EPS). The EPS acts as a physical barrier protecting the bacteria from antimicrobial agents and host immune responses. To combat this hurdle, the application of glycoside hydrolases (GH) has been investigated due to their ability to cleave particular structural polysaccharides within the EPS, thus breaking down the protective barrier and improving antibiotic clearance. While various studies demonstrate the capacity of GHs to improve antibiotic efficacy against biofilms in combination, there is clear differential …

Minutes, College Of Liberal Arts Faculty Meeting, Thursday, September 18, 2025, College Of Liberal Arts Faculty, Rollins College

The College of Liberal Arts Faculty Minutes

No abstract provided.

Molecular Analysis And Biochemical Profiling Of Bacteria From Domestics Dogs Saliva: A Pilot Study, Hadba Al-Amrah, Asseel Alotiby, Badriyah Aljuhani, Hadeel Huri, Noha Al Garni, Reem Aljedani, Zeina W. Sharawi

The Journal of King Abdulaziz University: Science

Microbiota is the collection of microorganisms living in a particular environment, such as the dog’s saliva. The aim of the present work was the detection of bacteriome that plays a crucial role in various ecological processes and has a significant impact on the health and functioning of their host organisms. We collected saliva samples from five dogs. After that, identify the unknown bacterial species by inoculating samples into the Swapped Mannitol Salt Agar (MSA) and MacConkey (MAC). In addition, These bacterial isolates were identified by using morphological characteristics, biochemical tests, and partial sequencing of their 16S rRNA gene.Results] appeared in …

A Case Study Of Long-Term Disease Burden In A Rural Community Near An Open Burn Facility, Arundhati Bakshi, Liana Baconguis, Md Abdullah Al-Mamun, Qingzhao Yu, Jennifer Richmond-Bryant, Stephania A. Cormier

School of Public Health Faculty Publications

Open burning and open detonation (OB/OD) of explosive and hazardous wastes creates various toxic waste products, including particulate matter, that is released into the atmosphere and capable of generating significant health impacts upon exposure. The last commercially run OB/OD thermal treatment facility in operation in the United States is located near the rural community of Colfax in central Louisiana. To evaluate the community’s concerns about the potential health impacts from air pollution due to the facility’s regular open burning of explosive and hazardous wastes, we examined the disease burden in Colfax compared to the surrounding parish and state. In a …