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Articles 6121 - 6150 of 31433
Full-Text Articles in Entire DC Network
When The Eyes Break The (Naturalistic) Scene: Investigation On The Eye-Gaze Following Mechanisms In Complex Scenarios, Bianca Monachesi, Anna Pecchinenda, Gustav Kuhn
When The Eyes Break The (Naturalistic) Scene: Investigation On The Eye-Gaze Following Mechanisms In Complex Scenarios, Bianca Monachesi, Anna Pecchinenda, Gustav Kuhn
School of Psychology
Processing eye-gaze and aligning one’s own attention with the gaze direction of others (gaze following) is a crucial ability and it underpins several cognitive and affective mechanisms. However, we know little about how this gaze following operates in realistic scenarios in adults. The present study addresses this gap by presenting naturalistic scenes, in which models were portrayed centrally or peripherally (7°), with their eye gaze directed straight ahead, averted towards an object (valid cue) or away from it (invalid cue), while maintaining a straight head position. Eye movements were recorded while participants (N = 60) performed two tasks: a free …
The Role And Influence Of Media Coverage And Social Media On Suicides: A Scoping Review, Kevin Miko Buac, Janine Trixia Austria, Claro Emmanuel Monsanto, Ma. Jamaica Monique Ponce, Arnold Christopher Soriano, Mystie Suzuki, Marc Eric S. Reyes
The Role And Influence Of Media Coverage And Social Media On Suicides: A Scoping Review, Kevin Miko Buac, Janine Trixia Austria, Claro Emmanuel Monsanto, Ma. Jamaica Monique Ponce, Arnold Christopher Soriano, Mystie Suzuki, Marc Eric S. Reyes
Makara Human Behavior Studies in Asia
Suicide is one of the leading causes of death worldwide. Numerous factors contribute to suicide ideation; recent studies highlight that the media’s presentation of suicide plays a significant role in influencing suicide ideation and attempts among their audience. This study aims to evaluate the extent of the literature on traditional media reporting and social media in the context of suicide ideation and attempts, considering social media as a distinct yet relevant domain with its widespread reach and user-driven nature. The PRISMA Extension for Scoping Reviews was employed to retrieve relevant studies and address the following questions: (1) What potential factors …
Understanding Sexual And Gender Minority Patients’ Experiences To Inform Provider Training, Marvin Allan Schilt-Solberg, Joseph Schwartz, Sarah Kiperman, Brayden Misiolek, Rick Zimmerman
Understanding Sexual And Gender Minority Patients’ Experiences To Inform Provider Training, Marvin Allan Schilt-Solberg, Joseph Schwartz, Sarah Kiperman, Brayden Misiolek, Rick Zimmerman
International Nursing Research Congress (INRC)
Background: Despite increasing visibility in the United States and worldwide, sexual and gender minority (SGM) individuals continue to face significant health disparities, including increased substance use (Schuler et al., 2018), poor mental health (SAMHSA, 2023), and risky HIV behaviors (Solberg et al., 2023). These disparities often stem from negative experiences within the healthcare system, resulting in delayed care or lack of care for health problems (Ayhan et al., 2019). This study seeks to understand the experiences of SGM individuals in healthcare settings and was guided by insights from Uncertainty Management Theory (Brashers, 2001).
Methods: Participants were recruited online and from …
Effects Of An App-Based Walking Program On Weight Management In Inflammatory Bowel Disease Patients, Youngjin Lee, Da-In Park, Saemi Kang, Da Bit Lee
Effects Of An App-Based Walking Program On Weight Management In Inflammatory Bowel Disease Patients, Youngjin Lee, Da-In Park, Saemi Kang, Da Bit Lee
International Nursing Research Congress (INRC)
Background: The global rise in obesity, driven by high-calorie diets and sedentary lifestyles, has become a significant public health issue. Simultaneously, the incidence of inflammatory bowel disease (IBD) is increasing. Obesity in IBD patients exacerbates symptoms, interferes with treatment and leads to additional complications. As a result, managing weight loss and preventing obesity are crucial for improving outcomes. This study aimed to evaluate the impact of a mobile app-based walking program for obese IBD patients at a clinical IBD center. The primary outcomes measured were body mass index (BMI), body fat percentage, and skeletal muscle mass.
Methods: This study was …
Investigating Potential Alzheimer's Disease Therapies Through An Agent-Based Model Of Impaired Microglia Metabolismmodeling Impaired Microglia Metabolism, Cheyenne Ty, Abigail Penland, John Gerving, Martin Mendoza-Ceja, Megan Pratt, Kamila Larripa
Investigating Potential Alzheimer's Disease Therapies Through An Agent-Based Model Of Impaired Microglia Metabolismmodeling Impaired Microglia Metabolism, Cheyenne Ty, Abigail Penland, John Gerving, Martin Mendoza-Ceja, Megan Pratt, Kamila Larripa
Spora: A Journal of Biomathematics
Alzheimer’s disease is the leading cause of dementia globally and is marked by amyloid-β plaque accumulation, decreased brain pH, disrupted metabolism, and increased permeability of the blood-brain barrier. Microglia, the resident immune cells of the central nervous system, are essential for maintaining brain homeostasis and are critically involved in the progression of AD. While microglia can initiate protective immune responses to injury and disease, dysregulated microglial metabolism may contribute to the exacerbation of Alzheimer's pathology. To investigate potential therapeutic strategies, we developed an agent-based model simulating the effects of exercise and metabolic enhancement on dysfunctional microglia. Our findings suggest that …
Ybx1-Mediated Activation Of Srebp2 Drives Sorafenib Resistance Via Cholesterol Biosynthesis In Hepatocellular Carcinoma, Veerababu Nagati, Dennis Kwabiah, Yamile Abuchard, Ana Ayala Pazzi, Shaibir Hussain, Salique H. Shaham, Manish Tripathi
Ybx1-Mediated Activation Of Srebp2 Drives Sorafenib Resistance Via Cholesterol Biosynthesis In Hepatocellular Carcinoma, Veerababu Nagati, Dennis Kwabiah, Yamile Abuchard, Ana Ayala Pazzi, Shaibir Hussain, Salique H. Shaham, Manish Tripathi
Research Colloquium
Background: Hepatocellular carcinoma (HCC) is an aggressive, largely chemo-resistant cancer with a poor prognosis and is the leading cause of cancer-related deaths worldwide. Currently, there is no effective systemic chemotherapy for HCC. Sorafenib is a multikinase inhibitor commonly used as the first-line treatment for advanced HCC. However, acquired drug resistance significantly limits its clinical effectiveness. The Y-box binding protein (YBX1) is an oncogenic RNA-binding protein found to be upregulated in sorafenib-resistant HCC cells and tissues.
Methods: HCC model SK Hep1, YBX1 overexpression, and knockdown cells were prepared by transient transfection with puromycin selection, and stable cell lines were established through …
Segmenting The Flour Beetle: Rnai Probes Into Embryonic Gene Function In Tribolium Castaneum, Sydney Do, J. Garcia, Ezzat El-Sherif
Segmenting The Flour Beetle: Rnai Probes Into Embryonic Gene Function In Tribolium Castaneum, Sydney Do, J. Garcia, Ezzat El-Sherif
Research Colloquium
Background: RNA interference (RNAi) silences specific gene expression through the introduction of double-stranded RNA (dsRNA). In Tribolium castaneum, RNAi enables precise manipulation of gene activity, allowing researchers to study developmental processes and genetic interactions across all life stages. dsRNA is processed by ribonucleases into small interfering RNAs (siRNAs) or microRNAs (miRNAs), which are recruited by the RNA-induced silencing complex (RISC), which targets and degrades specific mRNA molecules, allowing the observation of loss-of-function phenotypes.
T. castaneum offers advantages as a model for RNAi studies, including a fully annotated genome, a strong RNAi response, ease of application, and gene expression dynamics …
Implementing A Specific And Standardized Grading Scale For Therapeutic Injection Site Reactions To Improve Adverse Event Reporting, Priya Kale, Kavita Sarin
Implementing A Specific And Standardized Grading Scale For Therapeutic Injection Site Reactions To Improve Adverse Event Reporting, Priya Kale, Kavita Sarin
Research Colloquium
Up to 15.5% of patients taking biologic medication experience injection site reactions (ISRs) leading to morbidity, early discontinuation, and reduced treatment compliance. As biologic medications are increasingly used to treat chronic inflammatory conditions, including psoriasis and atopic dermatitis, there needs to be an improved understanding of ISRs. However, current methods of grading ISRs are nonspecific and unstandardized leading to a lack of understanding of medication-specific ISRs and ambiguity in perceptions of treatment tolerability. Here we aim to develop a standardized ISR grading scale for use in clinical trials. A scoping review was performed to evaluate current ISR grading scales and …
Alleviating Social And Psychological Ill-Being Research & Evaluation (Aspire) Study: Implementing An Act-Based Pathway For Patients In Primary Care, Monica C. Perez, Deepu George, Maria Hernandez, J. Garza, S. Solis
Alleviating Social And Psychological Ill-Being Research & Evaluation (Aspire) Study: Implementing An Act-Based Pathway For Patients In Primary Care, Monica C. Perez, Deepu George, Maria Hernandez, J. Garza, S. Solis
Research Colloquium
The Alleviating Social and Psychological Ill-being Research and Evaluation (ASPIRE) Study addresses a critical care gap for patients in the Rio Grande Valley by increasing access to behavioral health services within primary care. Psychosocial distress - including anxiety, depression, and lack of social support - negatively affects health outcomes and contributes to health disparities. The ASPIRE Study evaluates the impact of an Acceptance and Commitment Therapy (ACT)-based Psychological Flexibility (PF) Pathway on emotional well-being, systemic inflammation, and care engagement among patients in primary care settings.
Tc-Ptp Enhances Cordycepin-Induced Apoptosis In Human Pancreatic Cancer Cells, Olivia Samaie, Rodrigo Vidales, Lindsey Shim, Murali M. Yallapu, Subhash C. Chauhan, Mushfiq Hassan Shaikh, Dae Joon Kim
Tc-Ptp Enhances Cordycepin-Induced Apoptosis In Human Pancreatic Cancer Cells, Olivia Samaie, Rodrigo Vidales, Lindsey Shim, Murali M. Yallapu, Subhash C. Chauhan, Mushfiq Hassan Shaikh, Dae Joon Kim
Research Colloquium
Background: Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive malignancy marked by early metastasis, dense desmoplastic stroma, and profound resistance to conventional therapies. Despite the development of combination regimens such as gemcitabine and FOLFIRINOX, outcomes remain dismal, with median survival under one year for metastatic cases. This underscores the urgent need for novel therapeutic approaches that target multiple pathways simultaneously. T-cell protein tyrosine phosphatase (TC-PTP) is one of nonreceptor PTPs that negatively regulates oncogenic signaling pathways, particularly STAT3 and AKT, both of which are constitutively active in many solid tumors. Cordycepin, a nucleoside analogue derived from Cordyceps militaris, has …
Mthfr’S Role In Neuropsychiatric Disorders: Insights Into Precision Psychiatric Treatment, Anjana Ganesh, Nina Mourão, Elena Dike, Bharathi Gadad
Mthfr’S Role In Neuropsychiatric Disorders: Insights Into Precision Psychiatric Treatment, Anjana Ganesh, Nina Mourão, Elena Dike, Bharathi Gadad
Research Colloquium
Background: More than one in five U.S. adults live with a mental illness (1). Symptoms can range from mild to severe, with neuropsychiatric patients experiencing major difficulty in their daily activities. In 2021, an estimated 14.5 million adults in the United States had at least one major depressive episode with severe impairment in the past year (2). Treatment options currently include therapeutic and pharmacologic interventions based on large group data, but medications often take months to years to tailor to each patient. Genetic analysis provides an opportunity for personalized medicine for this vulnerable patient population through insight into the basis …
Genetic Analysis Of Strabismus, Nystagmus, And Associated Disorders, Nafiza Meher, Mayra Martinez Sanchez, Pablo Altschwager Kreft, Anne Fulton, Mary C. Whitman
Genetic Analysis Of Strabismus, Nystagmus, And Associated Disorders, Nafiza Meher, Mayra Martinez Sanchez, Pablo Altschwager Kreft, Anne Fulton, Mary C. Whitman
Research Colloquium
Strabismus and nystagmus are prevalent eye movement disorders that impair visual function and overall quality of life. Strabismus refers to the misalignment of the eyes, while nystagmus is involuntary oscillatory eye movements. Both may be isolated conditions or indicators of underlying ocular, neurological, or genetic causes. Although numerous genes have been associated with nystagmus related disorders, there is still much to be known regarding causes of idiopathic nystagmus. Strabismus, especially when occurring isolated, has no known genetic causes, hindering progress in early diagnosis and targeted management. This study utilizes next-generation whole-genome sequencing (WGS) to improve diagnostic outcomes, explore potential candidate …
Hnrnpk, A Potential Patient Biomarker Correlated With Lncrna Malat1 In Hepatocellular Carcinom, Mohammad Shabir Hussain, Salique H. Shaham, Veerababu Nagati, Yamile A. Anaya, Subhash C. Chauhan, Manish Kumar Tripathi
Hnrnpk, A Potential Patient Biomarker Correlated With Lncrna Malat1 In Hepatocellular Carcinom, Mohammad Shabir Hussain, Salique H. Shaham, Veerababu Nagati, Yamile A. Anaya, Subhash C. Chauhan, Manish Kumar Tripathi
Research Colloquium
Background and Aims: The liver is a vital organ involved in metabolism, and liver cancer represents a significant global health challenge, with an expected annual incidence to surpass one million cases worldwide by 2025. Hepatocellular carcinoma (HCC) is the most common type of primary liver cancer, making up about 90% of cases, and remains the fourth leading cause of cancer-related deaths worldwide. According to the American Cancer Society’s Cancer Facts & Figures 2025, an estimated 42,240 new cases of liver and intrahepatic bile duct cancer and 30,090 deaths are anticipated in the United States in 2025. In Texas, projections …
Analyses Of Nafld And Nash Transcriptome Reveal Unique Differentially Regulated Rnas And Cellular Pathways, Karla Perez, Frida Delgadillo, Subramanian Dhandayuthapani, Murali Yallapu, Subhash Chauhan, Enrique Ramos, Shrikanth Gadad
Analyses Of Nafld And Nash Transcriptome Reveal Unique Differentially Regulated Rnas And Cellular Pathways, Karla Perez, Frida Delgadillo, Subramanian Dhandayuthapani, Murali Yallapu, Subhash Chauhan, Enrique Ramos, Shrikanth Gadad
Research Colloquium
Background: Non-alcoholic fatty liver disease (NAFLD) is a progressive metabolic disorder affecting the liver, which can lead to non-alcoholic steatohepatitis (NASH), fibrosis, cirrhosis, and eventually hepatocellular carcinoma (HCC). Recent transcriptomic analyses have identified pathways that may be critical in disease progression and could serve as biomarkers or therapeutic targets. However, those studies were limited to transcripts encoding proteins, neglecting over 70% of the genome, which is composed of non-coding transcripts. Therefore, it is essential to reanalyze the transcriptomic data in an unbiased manner from normal, NAFLD, and NASH patient liver samples to identify transcripts with limited coding potential. These …
Comprehensive Review Of In Vitro Gut-Brain Axis Models In Parkinson’S Disease Research, John Nicholas Cauba, Jihoo Woo, Russell Wiggins, Shizue Mito
Comprehensive Review Of In Vitro Gut-Brain Axis Models In Parkinson’S Disease Research, John Nicholas Cauba, Jihoo Woo, Russell Wiggins, Shizue Mito
Research Colloquium
Background: The pathophysiology of Parkinson's Disease (PD) can be attributed to a gradually progressive dopaminergic neuron (DN) degeneration and aggregation of abnormal α-synuclein in the basal ganglia. While the classic paradigm of PD focuses on the role of neurotransmitter imbalance and motor impairments, there has been increasing scientific interest in the link between the intricate connection between gut dysbiosis with synucleinopathies and PD. This review explores the relevance of the Braak hypothesis, short-chain fatty acids (SCFAs) in neuronal viability, and gastrointestinal barrier dysfunction through the lens of in vitro modeling.
Methods: A collection of prospective literature was conducted …
Corticobasal Syndrome With Mixed Pathology In The Absence Of Grn Mutation: A Clinico-Pathological Case Of Ftld-Tdp With Coexisting Alzheimer’S And Lewy Body Pathology, Hugo Zamarron, David Irwin, Jeffery Phillips, Edward Lee, Matthew Tisdall, Corey Mcmillan
Corticobasal Syndrome With Mixed Pathology In The Absence Of Grn Mutation: A Clinico-Pathological Case Of Ftld-Tdp With Coexisting Alzheimer’S And Lewy Body Pathology, Hugo Zamarron, David Irwin, Jeffery Phillips, Edward Lee, Matthew Tisdall, Corey Mcmillan
Research Colloquium
Background: Corticobasal syndrome (CBS) is a neurodegenerative disorder characterized by often asymmetric fronto-pariteal and extra-pyramidal features that is traditionally associated with tauopathy, but pathological findings are heterogenous, including other forms of frontotemporal lobar degeneration (FTLD) and mixed pathologies of aging. We present clinical, radiographic, and histopathologic features of asymmetry in a unique patient with CBS and underlying FTLD with TDP-43 pathology (FTLD-TDP), co-occurring with other age-related pathologies.
Case Presentation: A 76-year-old man presented with progressive cognitive and motor dysfunction including asymmetric parkinsonism, left-sided dystonia and rigidity, apraxia, visuospatial impairment, and a subtle social disorder including apathy and social withdrawal. The …
Total Synthesis Of The Marine Cytotoxic Mansouramycin And Derivatives, Aditya Dantu, Gabriella L. Madrigal, Neel Gondi, David Osazee, Ahmad Amro, Whard Alsabbagh, Shizue Mito
Total Synthesis Of The Marine Cytotoxic Mansouramycin And Derivatives, Aditya Dantu, Gabriella L. Madrigal, Neel Gondi, David Osazee, Ahmad Amro, Whard Alsabbagh, Shizue Mito
Research Colloquium
Purpose: Isoquinolinequinones are a group of organic compounds which are composed of an isoquinoline fused to a quinone ring. This class of molecules is known to exhibit a wide variety of biological activities, including cytotoxic and antitumor properties. Among the many families of isoquinolinequinones are the Caulibugulones and Mansouramycins, which exhibit anticancer properties and are thus desirable subjects for cancer-related research. They are obtained by isolation from marine bryozoan Caulibugula intermis and marine Streptomyces sp respectively, however these compounds are difficult to extract. Thus, organic synthesis is being explored as a method of obtaining them; this project focuses on the …
Characterization And Purification Of Muc13 Monoclonal Antibodies: Techniques And Applications, Shabnam Malik, Daniel Zubieta, Mohammed Sikander, Sheema Khan, Murali Yallapu, Meena Jaggi, Subhash Chauhan
Characterization And Purification Of Muc13 Monoclonal Antibodies: Techniques And Applications, Shabnam Malik, Daniel Zubieta, Mohammed Sikander, Sheema Khan, Murali Yallapu, Meena Jaggi, Subhash Chauhan
Research Colloquium
Background: MUC13 is a transmembrane glycoprotein that is critically involved in the progression of various cancers, including liver, pancreatic, colon, and ovarian cancers. Despite the recognition of its presence and significance in these malignancies, the development of specific antibodies targeting MUC13 remains limited. This study aims to produce a monoclonal antibody against MUC13 and evaluate its effectiveness in assessing differential expression related to cancer progression.
Methodology: We utilized hybridoma technology to generate specific monoclonal antibodies targeting MUC13. Mouse splenocytes were immunized with recombinant MUC13 protein and subsequently fused with myeloma cells to create hybridomas. Positive clones were selected through ELISA …
Investigating Cucurbitacin D'S Efficacy In Ameliorating Benzo[A]Pyrene-Induced Hepatic Injury, Mohammed Sikander, Shabnam Malik, Daniel Zubieta, Anyssa Rodriguez, Fathi T. Halaweish, Murali Yallapu, Meena Jaggi, Subhash Chauhan
Investigating Cucurbitacin D'S Efficacy In Ameliorating Benzo[A]Pyrene-Induced Hepatic Injury, Mohammed Sikander, Shabnam Malik, Daniel Zubieta, Anyssa Rodriguez, Fathi T. Halaweish, Murali Yallapu, Meena Jaggi, Subhash Chauhan
Research Colloquium
Hepatocellular carcinoma (HCC) is increasingly linked to various co-morbidity factors, notably smoking, which introduces benzo[a]pyrene—a potent carcinogen known for its role in liver damage. Cucurbitacin, a triterpene with diverse biological activities, exhibits antioxidant, antiinflammatory, and anti-cancer properties, yet its hepatoprotective effects remain inadequately explored. In this study, we investigated the hepatoprotective activity of cucurbitacin D, a novel analog, against benzo[a]pyrene-induced liver injury in human HepG2 cells. To evaluate its protective effects, we conducted proliferation, clonogenicity, migration, invasion assays, alongside Western blotting and qPCR analyses. The DCFDA assay was employed to measure intracellular reactive oxygen species (ROS) levels in liver cells. …
Investigating Soil Co2 Flux Among Varying Soil Types During Inundation Conditions, Jennifer Volk, Arya Patel
Investigating Soil Co2 Flux Among Varying Soil Types During Inundation Conditions, Jennifer Volk, Arya Patel
The Pegasus Review: UCF Undergraduate Research Journal
Land use change has contributed to the increase of carbon dioxide (CO2) release, exacerbating global greenhouse gas (GHG) emissions. CO2 is also naturally produced in the soil via microbial respiration which breaks down soil organic matter (SOM). Several studies have investigated factors affecting CO2 flux from soils, but few have compared CO2 flux from a range of soil types under controlled conditions with varying water levels. This study subjected intact soil cores from six different soil types to varied periods of inundation and dry events using the same water and timing. During each event, CO …
From Imaging To Impact: A Multi-Disciplinary T32 Program Framework And Initial Insights For Training In Image-Guided Cancer Therapy, Kari J. Brewer Savannah, Stephen Y. Lai, Clifton D. Fuller, Kristy K. Brock
From Imaging To Impact: A Multi-Disciplinary T32 Program Framework And Initial Insights For Training In Image-Guided Cancer Therapy, Kari J. Brewer Savannah, Stephen Y. Lai, Clifton D. Fuller, Kristy K. Brock
Advances in Cancer Education and Quality Improvement
As multi-disciplinary image-guided assessment and therapies become increasingly important for precision oncology, the need for comprehensive training opportunities that effectively prepare the next generation of clinician-scientists and scientists is evident. We present an innovative, evidence-based research training framework that integrates the following critical features: 1) intentional and personalized mentoring and career development, 2) immersive research in image-guided cancer therapy, 3) strategic mentored clinical exposure, 4) structured didactic learning and professional development opportunities, and 5) mentored grant writing. Designed to foster scientific rigor, translational thinking, and multi-disciplinary collaboration, the Image-Guided Cancer Therapy T32 Training Program (IGCT-T32) aims to prepare postdoctoral fellows …
Antiplatelet Effects Of Angelica Dahurica Root Extract Without Gastric Lesion Formation In Rats, Pitiphat Srisom, Kasem Rattanapinyopituk, Uthai Sotanaphun, Rataya Luechapudiporn
Antiplatelet Effects Of Angelica Dahurica Root Extract Without Gastric Lesion Formation In Rats, Pitiphat Srisom, Kasem Rattanapinyopituk, Uthai Sotanaphun, Rataya Luechapudiporn
The Thai Journal of Pharmaceutical Sciences
Background: Platelet aggregation plays a crucial role in hemostasis; however, excessive platelet activation can lead to thrombus formation, contributing to cardiovascular diseases. While aspirin (acetylsalicylic acid [ASA]) is commonly used as an antiplatelet agent, its longterm use is associated with gastrointestinal side effects. Angelica dahurica (AD), a traditional herbal remedy, has shown in vitro antiplatelet activity and cyclooxygenase enzyme inhibition. However, its in vivo effects on platelet aggregation and gastric safety remain unclear.
Objectives: This study aimed to investigate whether Angelica dahurica root extract (ADE) could inhibit platelet aggregation and prevent aspirin-induced gastric lesions.
Materials and Methods: AD was extracted …
Bone-Sparing Effects Of Pueraria Mirifica Extract On Bone Loss In Androgen-Deficient Cynomolgus Macaques (Macaca Fascicularis), Thaweechai Saetae, Taratorn Kemthong, Sukanya Jaroenporn, Suchinda Malaivijitnond
Bone-Sparing Effects Of Pueraria Mirifica Extract On Bone Loss In Androgen-Deficient Cynomolgus Macaques (Macaca Fascicularis), Thaweechai Saetae, Taratorn Kemthong, Sukanya Jaroenporn, Suchinda Malaivijitnond
The Thai Journal of Pharmaceutical Sciences
Background: Synthetic estrogens provide remarkable benefits for bone health in men; however, they also present several drawbacks after long-term use. Pueraria mirifica, a phytoestrogen-rich herb, has garnered attention due to its positive effects and minimal adverse side effects on bone in females. Most research on bone health has been conducted on rodents; however, bone architecture and remodeling in rodents differ from those in humans, making it challenging to apply the results to clinical trials.
Objectives: Thus, this study assessed the bonesparing effects of P. mirifica extract (PME) in androgen-deficient male cynomolgus macaques.
Materials and Methods: Adult male macaques were divided …
Cytotoxic And Anti-Inflammatory Activities Of Extracts Of Pra-Sa-Ka-Phrao Remedy And Its Plant Components, Theeraphong Ninlaor, Arunporn Itharat, Srisopa Ruangnoo, Pakakrong Thongdeeying, Sunita Makchuchit, Pranporn Kuropakornpong, Settakul Boonyasakseree, Chadchom Choockong, Ninnart Intharit, Neal M. Davies
Cytotoxic And Anti-Inflammatory Activities Of Extracts Of Pra-Sa-Ka-Phrao Remedy And Its Plant Components, Theeraphong Ninlaor, Arunporn Itharat, Srisopa Ruangnoo, Pakakrong Thongdeeying, Sunita Makchuchit, Pranporn Kuropakornpong, Settakul Boonyasakseree, Chadchom Choockong, Ninnart Intharit, Neal M. Davies
The Thai Journal of Pharmaceutical Sciences
Background: Pra-Sa-Ka-Phrao (PSKP) is a traditional Thai remedy recognized in the National List of Essential Herbal Medicines of Thailand. It is traditionally used for treating flatulence and colic pain. It consists of eight components derived from plants with Ocimum tenuiflorum leaves as a main ingredient. However, there are no reports regarding the biological activities and chemical composition of PSKP.
Objectives: This study aimed to investigate cytotoxic activities, using cell lines related to the gastrointestinal (GI) system, and anti-inflammatory activities, along with chemical composition, of the PSKP complete formula (PSKPC) and a modified incomplete formula (PSKPIC).
Materials and Methods: Two extraction …
Isocratic Reversed-Phase High-Performance Liquid Chromatography Approach To Quantify Flutamide In Pharmaceuticals, Siddaraju Chikkalingaiah, Prathima Chikkegowda, Rajendraprasad Nagaraju
Isocratic Reversed-Phase High-Performance Liquid Chromatography Approach To Quantify Flutamide In Pharmaceuticals, Siddaraju Chikkalingaiah, Prathima Chikkegowda, Rajendraprasad Nagaraju
The Thai Journal of Pharmaceutical Sciences
Background: A non-steroidal antiandrogen, flutamide (FA), has been used often to treat advanced prostate cancer. It blocks testosterone’s tendency to bind to androgen receptors inside cells in some of the target organs, such as hair follicles, the prostate gland, skin, and testicles.
Objective: The main focus of the work is to produce an economical and reliable reversed-phase high-performance liquid chromatography technique for the quantitative study of FA in bulk materials and pharmaceuticals.
Materials and Methods: The elution of FA was done by running a mobile phase prepared by mixing 10 mM ammonium formate-formic acid buffer (pH-4) with methanol in the …
Screening And Evaluation Of Thai Herbal Plants As Multifunctional Agents For Targeting Amyloid Β Pathogenesis In Alzheimer's Disease, Ruedeemars Yubolphan, Suchinda Malaivijitnond, Sukanya Jaroenporn
Screening And Evaluation Of Thai Herbal Plants As Multifunctional Agents For Targeting Amyloid Β Pathogenesis In Alzheimer's Disease, Ruedeemars Yubolphan, Suchinda Malaivijitnond, Sukanya Jaroenporn
The Thai Journal of Pharmaceutical Sciences
Background: Alzheimer's disease (AD) is a neurodegenerative disorder driven by complex pathophysiological processes. Current therapeutic strategies emphasize the development of multifunctional agents, particularly those derived from natural sources, to target multiple stages of the amyloid β (Aβ) cascade, a central contributor to AD pathology.
Objectives: This study aimed to investigate the anti-Aβ activity of nine Thai herbs and evaluate their potential as multifunctional agents for AD treatment.
Methods: Nine Thai herbs—Caesalpinia sappan (CS), Thunbergia laurifolia (TL), Rhinacanthus nasutus (RN), Tabernaemontana divaricata (TD), Cyperus rotundus (CR), Terminalia chebula (TC), Azadirachta indica (AI), Piper retrofractum (PR), and Asparagus racemosus (AR)—were screened …
Nonlinear Dynamics Of Dust Acoustic Waves In A Dusty Plasma In Presence Of Two Opposite Polarity Dust Species, Omer A. Magzuob, Nauman Raza, Muntaha Khalid, Evren Hincal, Kottakkaran Sooppy Nisar
Nonlinear Dynamics Of Dust Acoustic Waves In A Dusty Plasma In Presence Of Two Opposite Polarity Dust Species, Omer A. Magzuob, Nauman Raza, Muntaha Khalid, Evren Hincal, Kottakkaran Sooppy Nisar
University of Bisha Journal for Basic and Applied Sciences
In a non-linear dynamical structure, this research presents a new analytical framework for examining the Zakharov-Kuznetsov equation in the realm of dusty ion-acoustic waves. Our objective is to produce a wide range of optical solitons at a reduced cost and time scale for evaluation by employing specific integration techniques. To achieve this, we are using two analytical approaches: the unified Ricatti equation procedure and the new extended auxiliary equation strategy. These methods help us to discover a variety of exact solutions for the governing model, including solitary, rational, elliptic functions, and periodic waves. Using numerical simulations and graphical representations, we …
Is Italy On Track? A Data-Driven Forecast For Road Transport Decarbonisation By 2030, Monica Bonacina, Romolo Consigna Tokong
Is Italy On Track? A Data-Driven Forecast For Road Transport Decarbonisation By 2030, Monica Bonacina, Romolo Consigna Tokong
Fondazione Eni Enrico Mattei Working Papers
The European Union’s decarbonisation strategy necessitates profound shifts across all sectors, with road transport presenting a particularly formidable challenge due to its sustained emissions growth since 1990. Given that Italy’s road transport sector is the third-largest consumer of fossil fuels in Europe, its role is pivotal in achieving these collective climate objectives. This study employs grey forecasting models to assess the projected contribution of alternative fuels – specifically biodiesel, bio-gasoline, biomethane, and electricity – to Italy’s 2030 decarbonisation pathway. The results suggest that consumption of these energy carriers will reach around 5 Mtoe (million tons of oil equivalent), representing a …
The Student Movement Volume 110 Issue 1: Andrews Assembles For A New School Year, Megan Constantine, Kyle Simpson, Melanie Webb, Audrey Lim, Lia Glass, Corinna Bevier, Isa Demoraes, Nicholas Gunn, Reagan Westerman, Aiko J. Ayala Rios, Samantha Woolford-Hunt, Anna Rybachek, Maya Thomas, Andrew Francis
The Student Movement Volume 110 Issue 1: Andrews Assembles For A New School Year, Megan Constantine, Kyle Simpson, Melanie Webb, Audrey Lim, Lia Glass, Corinna Bevier, Isa Demoraes, Nicholas Gunn, Reagan Westerman, Aiko J. Ayala Rios, Samantha Woolford-Hunt, Anna Rybachek, Maya Thomas, Andrew Francis
The Student Movement V. 110 (2025-2026)
HUMANS
Human Writer Introductions, Humans Writers
Becoming Disciple Makers: A Look Into Chaplain Fetrick's Vision for Andrews Unviersity, Megan Constantine
New at AU: Professor Carrie Hess, Kyle Simpson
ARTS & ENTERTAINMENT
Arts & Entertainment Writer Introductions, Arts & Entertainment Writers
Cut for Time: Recapping the 77th Emmy Awards, Melanie Webb
Team Conrad v. Team Jeremiah: The History and Appeal of Love Triangles in Media, Audrey Lim
The Summer of Superheroes, Lia Glass
Why I Hate the Trailer for the New 'Wutherinng Heights', Corinna Bevier
NEWS
News Writer Introduction, News Writers
Almost Anything Goes: A Night Lit in Neon, Isa DeMoraes …
Validation Of The Jefferson Health-Related Social Needs Screener, Sara Beachy, Kristin L. Rising, Richard W. Hass, Terry Hyslop, Isabella Muti, Mackenzie Kemp, Rhea E. Powell, Cara Martino, Baligh R. Yehia, Joseph G. Cacchione, Patricia C. Henwood
Validation Of The Jefferson Health-Related Social Needs Screener, Sara Beachy, Kristin L. Rising, Richard W. Hass, Terry Hyslop, Isabella Muti, Mackenzie Kemp, Rhea E. Powell, Cara Martino, Baligh R. Yehia, Joseph G. Cacchione, Patricia C. Henwood
Jefferson Hospital Staff Papers and Presentations
INTRODUCTION: Screening for health-related social needs (HRSN) is a growing national health priority. While multiple HRSN screening tools currently exist, none to our knowledge have been evaluated using robust statistical analyses. The goal of this work is to provide results from a validation study of the Jefferson HRSN screener conducted across inpatient and outpatient settings.
METHODS: This retrospective cross-sectional psychometric study included HRSN assessments conducted across inpatient and outpatient settings with adult patients from March 2023 to May 2024. The study was conducted across a 17-hospital academic health system serving a diverse community in a 9-county area crossing two states …