Digital Commons Network^™

Bioinformatic Analysis Of Pogz Variants In Relation To White Sutton Syndrome, Hannah Rollins

Theses

White-Sutton syndrome (WHSUS) is a rare neurodevelopmental disorder caused by mutations in the Pogo Transposable Element with ZNF Domain (POGZ) gene, which encodes pogo-transposable element with ZNF domain, a chromatin regulator essential for proper mitotic progression and DNA repair. This study uses a bioinformatic framework to evaluate the structural and functional impact of missense mutations in the conserved amino acid region (positions 500–800) of the POGZ protein. Protein modeling, variant effect prediction, conservation analysis, and molecular dynamics simulations were employed to gain an understanding of the effects of POGZ missense mutations on protein structure and movement with specific emphasis on …

International Headache Society Evidence-Based Guidelines On The Use Of Non-Invasive Neuromodulation Devices For The Acute And Preventive Treatment Of Migraine, Hsiangkuo Yuan, Serena L. Orr, Mohammad A. M. Al-Karagholi, Messoud Ashina, Fred Cohen, Hans-Christoph Diener, David W. Dodick, Rigmor Højland Jensen, Michael J. Marmura, Daniele Martinelli, Manjit S. Matharu, Anja S. Petersen, Patricia Pozo-Rosich, Simona Sacco, Lucy Simmonds, Cristina Tassorelli, Stewart J. Tepper, Gisela M. Terwindt, Shuu-Jiun Wang, Jiunn-Tyng Yeh, Stephen D. Silberstein

Department of Jefferson Headache Center Papers and Presentations

ObjectiveTo develop evidence-based clinical practice guidelines for non-invasive neuromodulation devices in acute and preventive migraine treatment.MethodsA systematic review was conducted across six databases from 1946 to April 2025. Randomized controlled trials evaluating Food and Drug Administration-cleared or Conformité Européenne (CE)-marked non-invasive neuromodulation devices were included. The quality of evidence was assessed using the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) methodology, and recommendations were developed through consensus following GRADE Evidence-to-Decision frameworks. The working group comprised 15 senior members and six junior members.ResultsFrom 1536 initial records, 15 studies met the inclusion criteria and were finally used to develop evidence-based recommendations. …

Genetic Entropy: A Critical Examination, Sarah Hunter

Science, Faith, and Origins

Genetic entropy is a hypothesis proposing that genomes deteriorate over time due to the gradual accumulation of slightly harmful mutations that natural selection cannot effectively remove. This paper explores the scientific debate surrounding this claim by examining differing perspectives on the theory of genetic entropy. Proponents of genetic entropy, such as John Sanford, argue that most mutations are deleterious and fall within a “near-neutral” range, allowing them to accumulate since their effects are too small for natural selection to detect. Evidence to support this claim includes Robert Carter and John Sanford’s research on the deterioration of the H1N1 viral genome …

Science, Sand, And Faith: Exploring Competing Explanations Of Coconino Sandstone, Emily Schneider

Science, Faith, and Origins

The Coconino Sandstone, a Permian rock layer found in the western United States, is a topic of debate among standard geologists and flood geologists. The conventional geological interpretation claims the sandstone is an eolian deposit, meaning the sediments were deposited by wind (McKee, 1979; Selley, 1968). In their view, key elements of the sandstone, like the cross-stratified beds, high degree of frosting, and the animal trackways, confirm the Coconino’s similarity to modern eolian dunes (McKee, 1979). As this rock layer is sandwiched between layers typically interpreted by flood geologists as being deposited during the flood, the idea that the Coconino …

Nsu Library Link - Fall 2025 - Volume 2.2, Nova Southeastern University

NSU Florida Link Newsletter

No abstract provided.

A Guide To Cicada Wings Of The United States Of America, George Keller

Department of Entomology: Distance Master of Science Projects

This guide was created for people who find cicada wings after a predator has eaten the body. It is nice to know what species of cicada was eaten. This guide will show some of the common species around the United States of America.

The template for the guide will be: Species, range, time of year, wing color, front/hind, wing length, and wing width.

All photos in the guide were taken by the author. The left wings of the cicadas are shown for easy comparison. If the specimen is too damaged then both wings will be shown.

Colony Collapse Disorder And How To Mitigate Losses, Axl Taylor

Department of Entomology: Distance Master of Science Projects

What is Colony Collapse Disorder?

The Role of Varroa destructor in CCD

Viruses and Their Role in CCD

Effects of Nosema in CCD

Habitat Destruction/Nutrition and Its Effect on CCD

Pesticides and their effect on CCD

Mitigating Causes of CCD

Colony Behavior, Social Resilience, and Monitoring

Integrated Management Approaches

Conclusion

Hyalophora Cecropia: An Educational Guide For Learning About And Raising Hyalophora Cecropia, Deserae Emmett

Department of Entomology: Distance Master of Science Projects

Ths is an educational guide for learning about and raising Hyalophora cecropia, also known as the cecropia moth, cecropia silkmoth, or robin moth, classified in the family Saturniidae.

Website: https://deseraeemmett.wixsite.com/ chasing-cecropia

Insect Evoluation Lesson, Melissa Adriano

Department of Entomology: Distance Master of Science Projects

The insect evolution Lesson Plan is a four-day course, to be taught sequentially through a week. All the materials presented are meant to be for ninth to tenth grades. The first day begins with a pre-test and an introduction to insect evolution. The following days will cover divergent evolution, convergent evolution, and co-evolution. Instructions are step-by-step in order to make possible the inquiry process. On the last day a review and a post-test for an overview of the knowledge acquired by the students. All activities and materials are available in the Appendix Section. The insect evolution lesson caters to the …

Closing The Loop On Textile Waste: Policy, Technology, And Consumer Behavior In Sustainable Fashion, Anthony Amotoe-Bondzie

Collected Student Papers

Textile waste has become one of the most visible consequences of the fashion industry’s linear production and consumption model, where materials are rapidly extracted, transformed, consumed, and discarded. This paper critically examines how sustainable fashion can move beyond isolated recycling efforts toward a more integrated circular economy framework. Rather than treating textile waste as only an end-of-life problem, the study analyzes it as a systems issue shaped by overproduction, weak product design, limited recovery infrastructure, fragmented regulation, and consumer habits that normalize short garment lifespans. The paper argues that closing the loop on textile waste requires coordinated interventions across policy, …

Exploring The Transformative Effects Of Calorie Restriction On The Lacrimal Gland In Adult Mice., Olivier Mauduit, Prashant Kumar, Kaitlin K Scholand, Emre Aksan, Laura Schaefer, Anmar Abu-Romman, Vanessa Delcroix, Zhiyuan Yu, Aude I Sindikubwabo, Ron Korstanje, Helen P Makarenkova, Cintia S De Paiva

Faculty Research 2025

Advanced age is one of the most recognizable risk factors for dry eye. Dry eye disease affects millions worldwide and can result from age-related lacrimal gland dysfunction, which correlates with a decline in lacrimal gland secretory cell function and chronic inflammation. This study investigated the potential of calorie restriction to maintain lacrimal gland and ocular surface health. Adult female C57BL/6 J mice were subjected to a 40% calorie restriction for 4 months, starting at 6-7 months and continuing until 10-11 months. These mice were compared to controls fed ad libitum. Bulk RNA sequencing of lacrimal glands, conjunctiva, and cornea subjected …

Humanized Mouse Models For Type 1 Diabetes., David V. Serreze, Marissa Tousey-Pfarrer, Jeremy Racine

Faculty Research 2025

T cell-mediated autoimmune type 1 diabetes (T1D) is under complex polygenic control in both humans and the NOD mouse model. However, in both species, particular major histocompatibility complex (MHC; designated HLA in humans) haplotypes provide the primary T1D risk factor. Both MHC/HLA class I and II variants interactively contribute to T1D by respectively driving autoreactive CD8 and CD4 T cell responses that cooperatively destroy insulin-producing pancreatic β cells. While NOD mice have provided important insights to the pathogenic basis of T1D, the model has so far provided only a limited means to identify possible clinically translatable disease intervention approaches. This …

Evaluation Of Hippocampal Dlgap2 Overexpression On Cognition, Synaptic Function, And Dendritic Spine Structure In A Translationally Relevant Ad Mouse Model., Andrew R Ouellette, Kristen M S O'Connell, Catherine Kaczorowski

Faculty Research 2025

INTRODUCTION: Developing effective therapeutics for Alzheimer's disease (AD) requires a better understanding of the molecular drivers of the disease. Our previous work nominated DLGAP2 as a modifier of age-related cognitive decline and risk for AD. We tested the hypothesis that overexpression of DLGAP2 in the hippocampus would protect against cognitive and synaptic deficits in a susceptible F1 5XFAD model.

METHODS: DLGAP2 was overexpressed in the hippocampus of F1 hybrid 5XFAD and non-transgenic littermates using a viral approach. Cognitive function, electrophysiological properties, and dendritic spine morphology were assessed at 6 and 14 months of age.

RESULTS: DLGAP2 overexpression impaired synaptic plasticity …

Genetic And Epigenetic Screens In Primary Human T Cells Link Candidate Causal Autoimmune Variants To T Cell Networks., Ching-Huang Ho, Maxwell A Dippel, Meghan S Mcquade, Leann P Nguyen, Arpit Mishra, Stephan Pribitzer, Samantha Hardy, Harshpreet Chandok, Florence M Chardon, Troy A Mcdiarmid, Hannah A Deberg, Jane H Buckner, Jay Shendure, Carl G De Boer, Michael H Guo, Ryan Tewhey, John P Ray

Faculty Research 2025

Genetic variants associated with autoimmune diseases are highly enriched within putative cis-regulatory regions of CD4⁺ T cells, suggesting that they could alter disease risk through changes in gene regulation. However, very few genetic variants have been shown to affect T cell gene expression or function. Here we tested >18,000 autoimmune disease-associated variants for allele-specific effects on expression using massively parallel reporter assays in primary human CD4⁺ T cells. We find 545 variants that modulate expression in an allele-specific manner (emVars). Primary T cell emVars greatly enrich for likely causal variants, are mediated by common upstream pathways and …

Expanding And Refining The Mammalian Phenotype Ontology To Enhance Disease Model Discovery., Susan M. Bello, Anna V Anagnostopoulos, Leigh Carmody, Nicolas Matentzoglu, Cynthia Smith

Faculty Research 2025

The mouse is a premier model system for investigating gene function and modeling human disease. For almost 40 years, Mouse Genome Informatics has worked to capture and integrate the data generated from mouse studies. A critical component of this integration is the development and use of the Mammalian Phenotype (MP) Ontology to capture the morphological and physiological effects of alterations to gene function in the mouse. As the wealth of phenotype data captured using the MP has expanded, its utility in the diagnosis of human disease has increased. Tools have been developed to use mouse and human phenotypes in variant …

Sociocultural And Environmental Changes And Their Biological Impact On Nonelite Polish Individuals, Paige A. Lynch

Anthropology ETDs

This dissertation integrates isotopic, biodistance, and skeletal stress data from cemeteries, Gać and Pień to study health and survival in the Polish–Lithuanian Commonwealth (PLC). The PLC (16th–18th centuries) in Poland was marked by religious migration, social inequality, and environmental change. Chapter 2 used a multiproxy approach to identify migrant status: most at Pień were local, about half at Gać were migrants, often biologically related to locals. Chapter 3 used stable isotope analyses to find minimal sex-based dietary differences, except for Pień females’ higher millet intake, and showed that market access and feudal systems influenced subsistence strategies. Chapter 4’s survival analyses …

Neuronal Activity-Dependent Gene Dysregulation In C9orf72 I3neuronal Models Of Als/Ftd Pathogenesis, Layla T. Ghaffari, Emily A. Welebob, Sarah E. Bond Newton, Ashley V. Boehringer, Kelly L. Cyliax, Piera Pasinelli, Davide Trotti, Aaron R. Haeusler

Farber Institute for Neuroscience Faculty Papers

The GGGGCC nucleotide repeat expansion (NRE) mutation in the C9ORF72 (C9) gene is the most common cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Neuronal activity plays an essential role in shaping biological processes within both healthy and neurodegenerative disease scenarios. Here, we show that at baseline conditions, C9-NRE-induced pluripotent stem cell-cortical neurons display aberrations in several pathways, including synaptic signaling and transcriptional machinery, potentially priming diseased neurons for an altered response to neuronal stimulation. Indeed, exposure to two pathophysiologically relevant stimulation modes, prolonged membrane depolarization or a blockade of K⁺ channels, followed by RNA sequencing, induces …

Issue 15: Pulmonary & Critical Care Insider, Bharat Bajantri Md, Sarah Ellsworth-Hoffman Mls, Kristin Lytal Pharmd, Mspgx, Stephanie Subart Pharmd

Critical Care & Pulmonary

Pulmonary & Critical Care Insider Issue 15

Compiled by Bharat Bajantri, MD, and librarian Sarah Ellsworth, MLS for the clinicians of the Pulmonary and Critical Care team of Parkview.

The Pulmonary & Critical Care Insider newsletter was created by Dr. Bharat Bajantri, MD and Sarah Ellsworth, MLS in 2023 as a form of current awareness for current practice at our hospital, Parkview Health.

Topics:

2025 Guidelines for ANCA Vasculitis

Airway Scaffolds for Emphysema: Six-Month BREATHE TRIAL Results

Tackling Emphysema-Related Hyperinflation: Scaffolds, Valves, or Vapor? How They Work?

Bactericidal vs. Bacteriostatic Antibiotics in Critically Ill Patients

Modified Cuff Leak Test (CLT) …

Icipe Monthly Digest – Volume 1, Issue 10, October 2025, International Centre Of Insect Physiology And Ecology (Icipe)

icipe Newsletters

No abstract provided.

Gonzaga Digital Scholarship & Publishing Newsletter, Fall 2025, Foley Center Library

Foley Library Publications

Volume 2 of the Digital Scholarship & Publishing Newsletter (formerly Gonzaga Institutional Repository Newsletter).

In this issue: 

• Learn about Pure Faculty Profiles
• Find out about the Digital Scholarship Lab @ Foley Library 
• Read about options for publishing OERs
• Explore how your department’s research and scholarship is represented in the IR
• Find out where to go for Copyright and Intellectual Property questions
• Data Management Plan consultations and options for support

Lawrence, Fall/Winter 2025, Lawrence University

Alumni Magazines

No abstract provided.

Campus Chronicle, Jayden Park

Campus Chronicle

Special Ankeny, Urban, Boone Issue

Ua 64/2 The Challenge: Magazine For The Center For Gifted Studies (No. 59 Fall 2025), Elizabeth Joyce Editor

Gifted Studies Publications

Magazine created by and about the WKU Center for Gifted Studies.

From Summer Institute To Action: Advancing Equity And Inclusion In Stem Classrooms, Sandie Han, Nadia Kennedy, Malgorzata Marciniak, Diana Samaroo

Publications and Research

This Editor’s Note provides background on the CUNY Innovative Teaching Academy Summer Institute for Equitable and Inclusive STEM Teaching and Learning and introduces the articles featured in this special issue.

Otterbein Towers Fall 2025, Otterbein University

Towers Magazine

Around the 'Bein; Innovative Funds; Committed to Career and Community; Faculty Excellence and Innovation; Two Years of Education for the Common Good; Homecoming and Family Weekend; Philanthropy; Alumni Matters; Class Notes.

Grand Valley Magazine, Vol. 25, No. 1, Fall 2025, Grand Valley State University

Grand Valley Magazine

Grand Valley Magazine is a quarterly publication about Grand Valley State University produced by University Communications since 2001.

Level Up: How Video Games Can Be Beneficial And Spark Creative Imagination In Players, Makendra M. Phipps

Honors Theses

Since the 2010’s, a technological trend has been flourishing: the development and enhancement of video games across different platforms. The early 1970s began the evolution of video game systems, from Atari and Magnavox Odyssey (1972) to Game Boy (1989) to Nintendo Switch 2 (2025) today. Video games themselves have also evolved, from the first basic computer games of the 1950s (such as OXO and Tennis for Two), to the introduction of arcade games in the 1970s (Pong, Space Invaders, PAC-Man), to the popular video games of today (Grand Theft Auto, Minecraft, Fortnite, R.E.P.O., to name …

From Chaos To Calm: How Ferappease Shapes Calf Behavior And Eases Weaning Woes, Rinna Tarter

Honors Theses

Weaning is widely recognized as one of the most stressful practices within the beef industry, as calves are separated from their dams and must manage changes in environment, social structure, and nutrition. This process provides indicators of stress, including increased vocalizations, reduced feed intake, pacing, and a stop in weight gain. Traditional management strategies include fenceline separation, nose flaps, and abrupt separation. Some research has begun to investigate approaches that target the biological mechanisms underlying the physiological stress response. One approach involves the use of a maternal bovine appeasing substance (mBAS), a synthetic analog of pheromones produced naturally by lactating …

Double Lenses: Understanding Adhd–Autism Comorbidity Across Gender And Pathways To Intervention, Grace A. Peak

Honors Theses

Each year, the number of people diagnosed with attention deficit hyperactivity disorder (ADHD) and Autism Spectrum Disorder (ASD) rises. This rising number is due to the abundance of research done on each disorder. Because of this increase in information, many adults and children are getting a comorbid diagnosis, meaning that they are being diagnosed with both disorders at the same time. There is one catch, however; research has shown that ADHD and ASD are spectrums, meaning that they have symptoms that can range in frequency and severity while also affecting each person differently. A large portion of the research conducted …

Maternal Nutritional Status And Immune Regulation In Early Offspring Development, Caroline C. Pagan

Honors Theses

Maternal nutrition, immune function, and microbiome health work together to shape fetal development in ways that influence health across the lifespan and even into future generations. This paper synthesizes evidence from molecular biology, nutrition science, immunology, and public health to show that essential nutrients-such as omega-3 fatty acids, folate, iron, zinc, and vitamin D-directly affect fetal immune programming, neurodevelopment, placental function, and metabolic regulation. Research on the maternal microbiome further demonstrates that microbial diversity and metabolite production modify nutrient absorption, inflammatory balance, and fetal gene expression, underscoring the microbiome’s role as both a mediator and amplifier of nutritional effects. At …