Open Access. Powered by Scholars. Published by Universities.®
- Discipline
-
- Life Sciences (8300)
- Medicine and Health Sciences (7491)
- Physical Sciences and Mathematics (4053)
- Social and Behavioral Sciences (3544)
- Medical Sciences (2995)
-
- Medical Specialties (2888)
- Plant Sciences (2036)
- Education (1866)
- Earth Sciences (1718)
- Biology (1648)
- Engineering (1616)
- Arts and Humanities (1605)
- Agronomy and Crop Sciences (1594)
- Agricultural Science (1566)
- Plant Biology (1552)
- Soil Science (1507)
- Plant Pathology (1488)
- Weed Science (1471)
- Psychology (1274)
- Oncology (1133)
- Medical Genetics (1123)
- Biomedical Informatics (1072)
- Bioinformatics (1052)
- Public Health (1044)
- Genetic Phenomena (1034)
- Law (944)
- Ecology and Evolutionary Biology (756)
- Diseases (716)
- Environmental Sciences (661)
- Chemistry (638)
- Institution
-
- The Texas Medical Center Library (2483)
- University of Kentucky (1834)
- University of Texas at Arlington (881)
- University of South Florida (516)
- Washington University School of Medicine (502)
-
- Liberty University (477)
- Thomas Jefferson University (476)
- Utah State University (443)
- University of Montana (426)
- University of Texas Rio Grande Valley (407)
- University of Plymouth (400)
- University of Nebraska - Lincoln (397)
- University of Arkansas, Fayetteville (396)
- TÜBİTAK (382)
- Walden University (361)
- Sultan Qaboos University (357)
- Nova Southeastern University (346)
- Old Dominion University (343)
- University of South Carolina (321)
- Brigham Young University (257)
- Edith Cowan University (255)
- Changsha University of Science and Technology (254)
- University of New Mexico (251)
- Arkansas State University (249)
- City University of New York (CUNY) (246)
- Portland State University (243)
- Universitas Indonesia (238)
- Chulalongkorn University (233)
- University of Baghdad (228)
- University of Central Florida (220)
- Keyword
-
- Humans (2196)
- Female (1270)
- Male (1188)
- Animals (1047)
- Mice (731)
-
- Middle Aged (601)
- Adult (574)
- Aged (504)
- ICTS (Institute of Clinical and Translational Sciences) (409)
- Tumor (257)
- Biomarkers (241)
- Mice, Inbred C57BL (233)
- Child (226)
- Adolescent (218)
- Biology (208)
- Machine learning (194)
- Mutation (192)
- Cell Line, Tumor (191)
- Disease Models, Animal (191)
- Inbred C57BL (187)
- Animal (182)
- Cell Line (177)
- Undergraduate (172)
- Neoplasms (170)
- Cancer (169)
- Young Adult (169)
- Mental health (168)
- Education (166)
- Artificial intelligence (161)
- COVID-19 (159)
- Publication
-
- IGC Proceedings (1977-2023) (1453)
- Faculty, Staff and Student Publications (1236)
- Faculty, Staff and Students Publications (954)
- Theses and Dissertations (898)
- 2020-Current year OA Pubs (494)
-
- Electronic Theses and Dissertations (453)
- Doctoral Dissertations and Projects (345)
- Walden Dissertations and Doctoral Studies (338)
- The Shorthorn Newspaper Collection: 1970s (310)
- Faculty Publications (258)
- Marine Ornithology (256)
- Food and Machinery (250)
- Research outputs 2022 to 2026 (243)
- Dissertations (228)
- Honors Theses (222)
- University of Montana Course Syllabi, 2021-2025 (220)
- Baghdad Science Journal (206)
- All Approved Curriculum (180)
- Master's Theses (178)
- Theses (166)
- Faculty Scholarship (147)
- Sultan Qaboos University Journal For Science (145)
- Graduate Theses and Dissertations (143)
- Journal of Agricultural and Marine Sciences (143)
- Graduate Theses, Dissertations, and Problem Reports (ETD) (137)
- All ETDs from UAB (135)
- Yale Graduate School of Arts and Sciences Dissertations (133)
- Undergraduate Student Symposium (126)
- Indian Journal of Health Sciences and Biomedical Research KLEU (120)
- Michigan Tech Publications (120)
- Publication Type
Articles 4831 - 4860 of 31393
Full-Text Articles in Entire DC Network
Re-Survey Of Blastocystis Infection In Free-Living Birds From Urban Xinxiang City, Xuehan Liu, Yingying Cao, Di An, Chengshui Liao, Ruibiao Wang, Bo Wen, Chunling Zhu, Huarun Sun, Longfei Zhang, Baoliang Qin, Yanhui Wang, Jianhe Hu, Yueyu Bai, Ke Ding, Lei Wang
Re-Survey Of Blastocystis Infection In Free-Living Birds From Urban Xinxiang City, Xuehan Liu, Yingying Cao, Di An, Chengshui Liao, Ruibiao Wang, Bo Wen, Chunling Zhu, Huarun Sun, Longfei Zhang, Baoliang Qin, Yanhui Wang, Jianhe Hu, Yueyu Bai, Ke Ding, Lei Wang
The Thai Journal of Veterinary Medicine
Blastocystis is the most ubiquitous intestinal protozoan parasite found in humans and animals worldwide. Commonly, ST7 and ST6 are the major Blastocystis subtypes reported in birds, and their frequencies fluctuate greatly with various factors. However, little literature is available on the prevalence and subtype characteristics of this parasite in free-living wild birds in the same city. For this purpose, a total of 114 fresh fecal specimens were collected from wild free-living birds in urban districts of Xinxiang city and tested for Blastocystis using PCR of the barcoding region of the small subunit ribosomal RNA (SSU rRNA) gene. The positive isolates …
Eleanor Arnason’S Fantastic Mitochondrial Humor, Sandra J. Lindow
Eleanor Arnason’S Fantastic Mitochondrial Humor, Sandra J. Lindow
Mythlore: A Journal of J.R.R. Tolkien, C.S. Lewis, Charles Williams, and Mythopoeic Literature
Eleanor Arnason’s Fantastic Mitochondrial Humor
In this essay I explore Brian Attebery’s description of mitochondrial fantasy to explain how humor works in Eleanor Arnason’s short fantastic fiction. Mitochondria are the energy powerhouses in cells. They are symbiotic creatures that once were separate but became an evolutionary part of a female egg cell, providing a history that can be traced to a Mitochondrial Eve. In Fantasy: How It Works, Attebery uses mitochondria metaphorically to explain how fantastic ideas evolve. Attebery describes fantastic mitochondria as “a cellular dynamo that lives within the tissues” of a story (91). He demonstrates how stories lead …
Lothlórien: Gendered Spaces, Cartographic Nominalism, And Galadriel’S Queerness, Bo Kampmann Walther
Lothlórien: Gendered Spaces, Cartographic Nominalism, And Galadriel’S Queerness, Bo Kampmann Walther
Mythlore: A Journal of J.R.R. Tolkien, C.S. Lewis, Charles Williams, and Mythopoeic Literature
Tolkien’s portrayal of Lothlórien is layered with complexities that reflect broader tensions between the feminine landscape and the masculine impulse to understand, name, and rationalize the world. This article examines the ‘fight’ over Lothlórien and its entitlement to truth from both female and male perspectives. It combines a close reading of passages from The Fellowship of the Ring with theories of name-giving, power, and mapping. The article concludes by evaluating these insights through the lens of Kristeva’s concept of the “abject” and discussing what ‘queer’ might mean in the Tolkien oeuvre.
Elopement And Marriage Among The Shakers, Tom Sakmyster
Elopement And Marriage Among The Shakers, Tom Sakmyster
Communal Societies
No abstract provided.
2017 - Appalachian Student Research Forum Award Winners, Appalachian Student Research Forum, East Tennessee State University
2017 - Appalachian Student Research Forum Award Winners, Appalachian Student Research Forum, East Tennessee State University
Appalachian Student Research Forum
No abstract provided.
Review Of The Benedictine Option: A Strategy For Christians In A Post-Christian Nation, Etta Madden
Review Of The Benedictine Option: A Strategy For Christians In A Post-Christian Nation, Etta Madden
Communal Societies
No abstract provided.
Primary Hyperaldosteronism, Joanna Lam
Primary Hyperaldosteronism, Joanna Lam
The Kabod
This paper will give an overview of primary hyperaldosteronism, which is a condition characterized by the excess production of aldosterone from the adrenal glands. Since its discovery in 1954 by James Conn, primary hyperaldosteronism has been discovered to have a variety of causes, with the more common ones being either benign tumors or inherited disorders such as congenital adrenal hyperplasia. Affected patients display conditions such as hypertension or hypokalemia, which may lead to symptoms including headaches, blurred vision, or dizziness. This paper will cover the anatomy of the adrenal glands, along with the normal physiology and synthesis of aldosterone. Aldosterone’s …
(((Qpie))) Prior Art 2 Of 9 Resonance Science, Teddy Burroughs
(((Qpie))) Prior Art 2 Of 9 Resonance Science, Teddy Burroughs
Defensive Publications Series
The Grand Unified Theory (QPIE)
Perspective Is Everything – What we are Believing, Expecting and Feeling in Life Matters
(((QPIE))) Prior Art Disclosure Part 2 of 9
(((QPIE))) Prior Art Disclosure - Frontiers & Strategic Coherence
(((QPIE)))33 Resonance Science Edition
(CREDIT: (((QPIE))) Created by Teddy Burroughs with Inspirational contributions by: Aleah Burroughs, Reya Burroughs April Saunders, Claudette Clare, Perry Mason, Shomari Chinnery
Technical Email:
Social Enterprise Email:
DIRECT Funding Email:
#Avision4Change #Vision2Funding #Charity2Roi #TedFunding #QPIE
#ResonanceOS #Voyager9.9 #RaaS #CaaS #Sla
(All funds to help us expand our Resonance Frameworks can be …
(((Qpie))) Prior Art 1 Of 9 Quantum Perspective Is Everything, Teddy Burroughs
(((Qpie))) Prior Art 1 Of 9 Quantum Perspective Is Everything, Teddy Burroughs
Defensive Publications Series
The Grand Unified Theory (QPIE)
Perspective Is Everything – What we are Believing, Expecting and Feeling in Life Matters
(((QPIE))) Prior Art Disclosure Part 1 of 9
(((QPIE))) Quantum Perspective Is Everything
Prior Art /IP Declaration
https://quteframework.wordpress.com/2025/09/22/qpie-qpie-prior-art-part-1-of-9/
https://www.linkedin.com/pulse/qpie-prior-art-disclosure-part-1-9-teddy-burroughs-kdr4c
(CREDIT: (((QPIE))) Created and discovered by Teddy Burroughs with significant contributions by: Kaiya Burroughs, Aleah Burroughs, April Saunders and Perry Mason ([email protected]) Avision4Change Vision2Funding #Charity2Roi
Paypal @TedFunding33 CA: $TedFunding33)
09/22/2025 Brooklyn NYC USA 🇺🇸
(Formatted as defensible prior art disclosure)
Abstract
This document discloses (((QPIE)))—Quantum Perspective Is Everything—a resonance-based grand unifying framework that harmonizes mental, physical, and emotional dimensions of human and …
2025 October 10 - State Of The University Address, Office Of The President, East Tennessee State University
2025 October 10 - State Of The University Address, Office Of The President, East Tennessee State University
Office of the President Speeches
No abstract provided.
Crayfishes Of Kansas: List Of Taxa, Synonyms, And References, Mark E. Eberle
Crayfishes Of Kansas: List Of Taxa, Synonyms, And References, Mark E. Eberle
Sternberg Museum of Natural History Faculty Publications
There are 14 species of crayfishes (Decapoda: Cambaridae) reported from Kansas, although there are questions about the systematics of some taxa. These species are listed by their current names and the synonyms under which they have been reported since 1885, along with their conservation status. Published references that include each species in Kansas are also noted. In addition, information about species with type localities in Kansas and unresolved taxonomic issues are summarized. The list of species has been updated in 2025 to include two species introduced to Kansas and other new information.
The Impacts Of Chronic Infections On Shaping Cellular Senescence, Ashley Johnson, Troy Rought, Jacob Aronov, Princess Pokharel, Angelina Chiu, Azadeh Nasuhidehnavi
The Impacts Of Chronic Infections On Shaping Cellular Senescence, Ashley Johnson, Troy Rought, Jacob Aronov, Princess Pokharel, Angelina Chiu, Azadeh Nasuhidehnavi
Pharmacy Faculty Scholarship
Cellular senescence is a fundamental biological process characterized by stable cell cycle arrest, genomic instability, and the acquisition of a proinflammatory secretory phenotype. While senescence is traditionally associated with aging, growing evidence reveals that chronic infections such as viral, bacterial, and protozoan parasites can serve as powerful inducers of senescence, contributing to premature aging and long-term tissue damage. This review explores the diverse mechanisms by which persistent pathogens trigger or sustain senescence in host cells. We highlight how these chronic infections manipulate host DNA repair, mitochondrial dynamics, telomere maintenance, oxidative stress, and immune function to promote senescence and immunosenescence. Emerging …
Draft Genome Sequences Of Burkholderia And Paraburkholderia Strains Isolated From Panicum Virgatum Soil And Roots At The Lux Arbor Reserve In Michigan, Usa, H. Kehlet-Delgado, R. H. Petipas, A. A. Antoch, Jeffrey S. Norman, X. Li, R. A. White Iii, S. E. Evans, L. K. Tiemann, M. L. Friesen
Draft Genome Sequences Of Burkholderia And Paraburkholderia Strains Isolated From Panicum Virgatum Soil And Roots At The Lux Arbor Reserve In Michigan, Usa, H. Kehlet-Delgado, R. H. Petipas, A. A. Antoch, Jeffrey S. Norman, X. Li, R. A. White Iii, S. E. Evans, L. K. Tiemann, M. L. Friesen
Biology Faculty Works
We present draft genomes of two Paraburkholderia strains and two Burkholderia strains. Three strains were isolated from surrounding soils and one from roots of switchgrass (Panicum virgatum) in Michigan, USA.
The Potential Of National Parks And Protected Areas In The Anthropocene: Emerging Incubators Of Environmental Justice And Co-Stewardship Conservation, Yolonda Youngs
Geography and Environmental Studies Faculty Publications
National parks are often praised as natural labs for physical science researchers and scholars. They are also cultural labs where ideas about public lands management, use, and access are reformulated and revised. In the Anthropocene, these sites hold special relevance. Within this context, parks can serve as active and evolving incubators of social and climate resilience guided by just conservation initiatives. Yet few studies have explored the new models of collaboration and partnerships between the U.S. National Park Service and Tribal Nations that seek to create co-stewardship conservation. This article addresses that gap with a qualitative and historical case study …
Board Of Trustees Agenda, Oct. 10 2025, Indiana State University Board Of Trustees
Board Of Trustees Agenda, Oct. 10 2025, Indiana State University Board Of Trustees
Board of Trustees
No abstract provided.
Predictors Of Lower-Limb Arterial Occlusion Pressure Across Commonly Used Cuff Widths, Isaac J. Wedig, Isaac M. Lennox, Erich J. Petushek, John J. Durocher, John Mcdaniel, Steven J. Elmer
Predictors Of Lower-Limb Arterial Occlusion Pressure Across Commonly Used Cuff Widths, Isaac J. Wedig, Isaac M. Lennox, Erich J. Petushek, John J. Durocher, John Mcdaniel, Steven J. Elmer
Michigan Tech Publications
We compared predictors of lower-limb arterial occlusion pressure (AOP) across commonly used blood flow restriction (BFR) cuff widths (11, 13, 18 cm) and developed prediction equations to estimate AOP for each cuff. Participants (n = 116) underwent measurements of thigh circumference (TC), systolic (SBP) and diastolic (DBP) blood pressure, and AOP was assessed using Doppler ultrasound in a seated position. Multiple linear regression models with commonality analysis and mixed-effects models were used to identify and compare predictors of AOP between each cuff. LASSO regression with bootstrap resampling was used to develop and internally validate prediction equations. TC, SBP, DBP, age, …
Representation, Dynamics And Optimization Of Physical Structures, Fan Feng
Representation, Dynamics And Optimization Of Physical Structures, Fan Feng
Dartmouth College Ph.D Dissertations
Computational tools play a vital role in structural analysis and design, enabling engineers and researchers to optimize performance, reduce material usage, and explore novel configurations across solids and fluids. Capturing, analyzing, and optimizing these structures while balancing efficiency, stability, and adaptability remains a central challenge. This thesis proposes three complementary methods that advance representation, simulation, and optimization. We present an impulse (gauge) fluid formulation that utilizes the impulse gauge variable to reduce numerical diffusion and better preserve coherent flow features such as vorticity at practical resolutions. We introduce a differentiable Voronoi representation for cellular solids that provides smooth implicit boundaries …
Embung Desa Dan Adaptasi Perubahan Iklim: Analisis Empiris Perlindungan Lahan Pertanian Indonesia Dari Ancaman Kekeringan, Danan Perri Sandria, Asri Yuliani
Embung Desa Dan Adaptasi Perubahan Iklim: Analisis Empiris Perlindungan Lahan Pertanian Indonesia Dari Ancaman Kekeringan, Danan Perri Sandria, Asri Yuliani
Jurnal Kebijakan Ekonomi
This study analyzes the contribution of village ponds to mitigating agricultural land damage caused by drought in Indonesia. Using quantitative methods with linear regression models on data from 78.291 villages, the research tests the effectiveness of micro-water infrastructure as a disaster mitigation instrument. Findings indicate that village ponds significantly reduce the area of crop failure, although their effectiveness declines during extreme droughts due to limited storage capacity. Policy implications emphasize transforming physical pond construction into adaptive management through integrated closed distribution technology and strengthened local institutions to ensure farmers' economic resilience against global climate anomalies.
Evaluation Of An In Situ Forming Composite Hydrogel Based On Gelatin–Sodium Alginate– Polyethylene Oxide For Biomedical Applications: Effect Of Incorporated Sophora Japonica On Hydrogel Performance, Samar A. Salim
Nanotechnology Research Centre
Hydrogels are ideal candidates for biomedical applications such as wound healing, tissue engineering, and bone regeneration due to their porosity and similarity to the extracellular matrix of humans. A gelatin/ sodium alginate (SA) hydrogel with the inclusion of polyethylene oxide (PEO) was utilized to achieve enhanced mechanical strength. Hydrogels were prepared at different ratios of polymer solutions to select the hydrogel that exhibited an optimal gelation time. Sophora japonica, a plant leaf extract (SJLE) rich in flavonoids and isoflavonoids, was added to the hydrogel to enhance tissue repair. The developed hydrogels were extensively characterized for their morphology, porosity, and swelling …
Ligand-Receptor Interactions Induce And Mediate Regulatory Functions Of Batf3+ B Cells, Hui Yan, Rui Wang, Suryavathi Viswanadhapalli, Christian Cervantes, Funan He, Shuai Wu, Azad Khosh, Weiwei Luo, Jingwei Wang, Maria J Fernandez, Uday P Pratap, Mustafa Khan, Karli Hinton, Sai Eashan Vankamamidi, Dariela Perez, Carlos E Rivera, Harshita B Gupta, Fushun Zhang, Zhenqing Ye, Yidong Chen, Xiao-Dong Li, Gangadhara R Sareddy, Hong Zan, Yue Li, Exing Wang, Evelien M Bunnik, Guangming Zhong, Christopher A Hunter, Ross M Kedl, Zhinan Yin, Booki Min, Diako Ebrahimi, Siyuan Zheng, Tyler J Curiel, Yan Xiang, Ratna K Vadlamudi, Paolo Casali, Zhenming Xu
Ligand-Receptor Interactions Induce And Mediate Regulatory Functions Of Batf3+ B Cells, Hui Yan, Rui Wang, Suryavathi Viswanadhapalli, Christian Cervantes, Funan He, Shuai Wu, Azad Khosh, Weiwei Luo, Jingwei Wang, Maria J Fernandez, Uday P Pratap, Mustafa Khan, Karli Hinton, Sai Eashan Vankamamidi, Dariela Perez, Carlos E Rivera, Harshita B Gupta, Fushun Zhang, Zhenqing Ye, Yidong Chen, Xiao-Dong Li, Gangadhara R Sareddy, Hong Zan, Yue Li, Exing Wang, Evelien M Bunnik, Guangming Zhong, Christopher A Hunter, Ross M Kedl, Zhinan Yin, Booki Min, Diako Ebrahimi, Siyuan Zheng, Tyler J Curiel, Yan Xiang, Ratna K Vadlamudi, Paolo Casali, Zhenming Xu
Faculty, Staff and Student Publications
B cells express many protein ligands, yet their regulatory functions are incompletely understood. We profiled ligand expression across murine B sublineage cells, including those activated by defined receptor signals, and assessed their regulatory capacities and specificities through in silico analysis of ligand-receptor interactions. Consequently, we identified a B cell subset that expressed cytokine interleukin-27 (IL-27) and chemokine CXCL10. Through the IL-27–IL-27 receptor interaction, these IL-27/CXCL10-producing B cells targeted CD40-activated B cells in vitro and, upon induction by immunization and viral infection, optimized antibody responses and antiviral immunity in vivo. Also present in breast cancer tumors and retained there through CXCL10-CXCR3 …
Factors Influencing Plant Community Structure And Composition Of Restored Tamaulipan Thornscrub Forests, Jerald T. Garrett, Audrey J. Hicks, Christopher A. Gabler
Factors Influencing Plant Community Structure And Composition Of Restored Tamaulipan Thornscrub Forests, Jerald T. Garrett, Audrey J. Hicks, Christopher A. Gabler
School of Earth, Environmental, & Marine Sciences Faculty Publications
The Lower Rio Grande Valley (LRGV) of Texas is a biodiversity hotspot due to its high alpha, beta, and gamma diversity and high regional endemism, which are at high risk of degradation. The region has lost 95% of its native thornforest habitat primarily due to agricultural and urban expansion. This study aims to evaluate the current vegetative structure and composition of restored thornforest sites located in the LRGV to identify restoration methods and site characteristics that affect forest restoration outcomes. Twelve restored thornforest sites were selected for this study that varied in time since restoration, patch size, degree of isolation, …
Navigating Night Shift: The Role Of A Clinical Resource Nurse, Jodie Gord, Ashley Burbey
Navigating Night Shift: The Role Of A Clinical Resource Nurse, Jodie Gord, Ashley Burbey
Nursing
No abstract provided.
Young Carers In Early Childhood - Exploring Experience With The Power Threat Meaning Framework, Carly Ellicott, Alyson Norman, Helen Lloyd, Felicity Dewsbery, Sarah Jones, Shoshana Jones
Young Carers In Early Childhood - Exploring Experience With The Power Threat Meaning Framework, Carly Ellicott, Alyson Norman, Helen Lloyd, Felicity Dewsbery, Sarah Jones, Shoshana Jones
School of Psychology
This paper presents the first exploration of young carers in early childhood (YCEC), in the context of whole family support, through the application of the Power Threat Meaning Framework (PTMF). Existing contributions to young carer research have shaped social policy, legislation, and practice concerned with whole family approaches to the identification, assessment, and support for young carers globally. To date, the literature has predominantly focused on young carers in middle childhood to young adulthood, contributing to socially constructed Eurocentric ideologies of who young carers are likely to be. As such, YCEC remain disempowered in broader young carer and family science …
Just-In-Time Adaptive Intervention To Improve Hiv Prevention And Substance Use In Youth Experiencing Homelessness (My-Ride): Protocol For A Randomized Controlled Trial, Diane Santa Maria, Nikhil Padhye, Michael Businelle, Natasha Slesnick, Stefani Ricondo, Marguerita Lightfoot
Just-In-Time Adaptive Intervention To Improve Hiv Prevention And Substance Use In Youth Experiencing Homelessness (My-Ride): Protocol For A Randomized Controlled Trial, Diane Santa Maria, Nikhil Padhye, Michael Businelle, Natasha Slesnick, Stefani Ricondo, Marguerita Lightfoot
Faculty, Staff and Students Publications
Background: Youth who are experiencing homelessness face a higher risk of HIV infection compared to their housed peers, and suicide and overdose remain the leading causes of death among homeless youth. Just-in-Time Adaptive Interventions (JITAIs) are gaining momentum for HIV prevention and substance use research. Yet, most interventions for homeless youth have not addressed modifiable real-time factors.
Objective: This paper describes the development and implementation of a randomized attention-controlled trial to assess the efficacy of motivating youth to reduce infections, disconnections, and emotional dysregulation (MY-RIDE), a JITAI to improve HIV prevention and substance use in homeless youth.
Methods: This study …
The Effect Of Type 2 Diabetes Genetic Predisposition On Non-Cardiovascular Comorbidities, Ana Luiza Arruda, Ozvan Bocher, Henry J Taylor, Davis Cammann, Satoshi Yoshiji, Xianyong Yin, Chi Zhao, Jingchun Chen, Alexis C Wood, Ken Suzuki, Josep M Mercader, Cassandra N Spracklen, James B Meigs, Marijana Vujkovic, George Davey Smith, Jerome I Rotter, Benjamin F Voight, Andrew P Morris, Eleftheria Zeggini
The Effect Of Type 2 Diabetes Genetic Predisposition On Non-Cardiovascular Comorbidities, Ana Luiza Arruda, Ozvan Bocher, Henry J Taylor, Davis Cammann, Satoshi Yoshiji, Xianyong Yin, Chi Zhao, Jingchun Chen, Alexis C Wood, Ken Suzuki, Josep M Mercader, Cassandra N Spracklen, James B Meigs, Marijana Vujkovic, George Davey Smith, Jerome I Rotter, Benjamin F Voight, Andrew P Morris, Eleftheria Zeggini
Faculty, Staff and Students Publications
Type 2 diabetes is associated with a range of non-cardiovascular non-oncologic comorbidities. To move beyond associations and evaluate causal effects between type 2 diabetes genetic predisposition and 21 comorbidities, we apply Mendelian randomization analysis using genome-wide association studies across multiple genetic ancestries. Additionally, leveraging eight mechanistic clusters of type 2 diabetes genetic profiles, each representing distinct biological pathways, we investigate causal links between cluster-stratified type 2 diabetes genetic predisposition and comorbidity risk. We identify causal effects of type 2 diabetes genetic predisposition driven by distinct genetic clusters. For example, the risk-increasing effects of type 2 diabetes genetic predisposition on cataracts …
Vaccine And Treatment Evaluation Units: A Historical Perspective, Robert B Belshe, David I Bernstein, Kathryn M Edwards, Sharon E Frey, Wendy A Keitel, Myron M Levine, John J Treanor, Peter F Wright
Vaccine And Treatment Evaluation Units: A Historical Perspective, Robert B Belshe, David I Bernstein, Kathryn M Edwards, Sharon E Frey, Wendy A Keitel, Myron M Levine, John J Treanor, Peter F Wright
Faculty, Staff and Students Publications
On 27 February 1962, Surgeon General Luther Terry announced a new vaccine development program within the National Institute of Allergy and Infectious Diseases (NIAID). Initially, the plan had three components: (1) special laboratories and facilities for development of prototype vaccines; (2) pilot lot production facilities and preliminary vaccine trial sites; and (3) larger lot production capacity and expanded human testing. Respiratory viruses were targeted as the top priority for vaccine development. Over 5 decades, this program has evolved and expanded to include multiple academic vaccine evaluation sites within the network, now labeled as the Vaccine and Treatment Evaluation Units (VTEUs). …
Dna Methylation And Machine Learning: Challenges And Perspective Toward Enhanced Clinical Diagnostics, Erfan Aref-Eshghi, Arash B Abadi, Mohammad-Erfan Farhadieh, Amirreza Hooshmand, Fatemeh Ghasemi, Leila Youssefian, Hassan Vahidnezhad, Taylor Martin Kerrins, Xiaonan Zhao, Mahdi Akbarzadeh, Hakon Hakonarson, Amir Hossein Saeidian
Dna Methylation And Machine Learning: Challenges And Perspective Toward Enhanced Clinical Diagnostics, Erfan Aref-Eshghi, Arash B Abadi, Mohammad-Erfan Farhadieh, Amirreza Hooshmand, Fatemeh Ghasemi, Leila Youssefian, Hassan Vahidnezhad, Taylor Martin Kerrins, Xiaonan Zhao, Mahdi Akbarzadeh, Hakon Hakonarson, Amir Hossein Saeidian
Faculty, Staff and Students Publications
DNA methylation is an epigenetic modification that regulates gene expression by adding methyl groups to DNA, affecting cellular function and disease development. Machine learning, a subset of artificial intelligence, analyzes large datasets to identify patterns and make predictions. Over the past two decades, advances in bioinformatics technologies for arrays and sequencing have generated vast amounts of data, leading to the widespread adoption of machine learning methods for analyzing complex biological information for medical problems. This review explores recent advancements in DNA methylation studies that leverage emerging machine learning techniques for more precise, comprehensive, and rapid patient diagnostics based on DNA …
Discriminative Accuracy Of Cha2ds2-Vasc Score, And Development Of Predictive Accuracy Model Using Machine Learning For Ischemic Stroke Risk In Cardiac Amyloidosis And Atrial Fibrillation, Waqas Ullah, Abhinav Nair, Eric Warner, Salman Zahid, Mansoor Rahman, Palwasha Khan, Indranee Rajapreyar, Sridhara S. Yaddanapudi, M. Chadi Alraies, Said Ashraf, Jeffery Van Hook, Yegeny Brailovsky
Discriminative Accuracy Of Cha2ds2-Vasc Score, And Development Of Predictive Accuracy Model Using Machine Learning For Ischemic Stroke Risk In Cardiac Amyloidosis And Atrial Fibrillation, Waqas Ullah, Abhinav Nair, Eric Warner, Salman Zahid, Mansoor Rahman, Palwasha Khan, Indranee Rajapreyar, Sridhara S. Yaddanapudi, M. Chadi Alraies, Said Ashraf, Jeffery Van Hook, Yegeny Brailovsky
Department of Medicine Faculty Papers
BACKGROUND: CHA2DS2-VASc score in cardiac amyloidosis (CA) with atrial fibrillation (AF) is believed to underestimate ischemic stroke risk, necessitating a better predictive model.
METHODS: Data were obtained from the National Readmission Database (NRD). Outcomes between CA-AF and no-CA-AF were compared using multivariate regression analysis to calculate adjusted odds ratios (aORs). AutoScore, an interpretable machine learning framework, was used to develop a stroke risk prediction model, and its predictive accuracy was evaluated with an area under the curve (AUC) using the receiver operating characteristic analysis.
RESULTS: A total of 11,860,804 (CA-AF 22,687 (0.19%) and no-CA-AF 11,838,117) patients were identified from 2015 …
Targeting The Bcl2 Family: Advances And Challenges In Bh3 Mimetic-Based Therapies, Nabanita Mukherjee, James Sheetz, Yiqun Shellman
Targeting The Bcl2 Family: Advances And Challenges In Bh3 Mimetic-Based Therapies, Nabanita Mukherjee, James Sheetz, Yiqun Shellman
Student Papers, Posters & Projects
The BCL2 family of proteins plays a pivotal role in regulating apoptosis and cellular homeostasis, making them critical therapeutic targets in cancer and other diseases characterized by pathological cell survival. BH3 mimetics, small molecules that selectively inhibit anti-apoptotic BCL2 family members, have achieved significant clinical success, particularly in hematologic malignancies. However, several challenges remain, including resistance mechanisms, toxicity (such as MCL1 inhibitor-associated cardiotoxicity), and the intricate balance between apoptotic and non-apoptotic functions. This review provides a comprehensive overview of BCL2 family biology, the development and clinical application and outcomes of BH3 mimetics, and the emerging resistance mechanism known as double-bolt …
Glucagon-Like Peptide 1 Receptor Agonists And The Clinical Outcomes Of Inflammatory Bowel Disease: A Systematic Review And Meta-Analysis, Ahmed B. Bayoumy, Lindsay M. Clarke, Parakkal Deepak, Aakash Desai, Priya Sehgal, Uri Gorelik, Haggai Bar-Yoseph, Marie Villumsen, Chris J. J. Mulder, Dirk J. Stenvers, Maarten E. Tushuizen, Nanne K. H. De Boer
Glucagon-Like Peptide 1 Receptor Agonists And The Clinical Outcomes Of Inflammatory Bowel Disease: A Systematic Review And Meta-Analysis, Ahmed B. Bayoumy, Lindsay M. Clarke, Parakkal Deepak, Aakash Desai, Priya Sehgal, Uri Gorelik, Haggai Bar-Yoseph, Marie Villumsen, Chris J. J. Mulder, Dirk J. Stenvers, Maarten E. Tushuizen, Nanne K. H. De Boer
Division of Gastroenterology and Hepatology Faculty Papers
BACKGROUND: Prior studies showed worse outcomes in obese inflammatory bowel disease (IBD) patients, especially those related to hospitalizations, surgery, and steroid-free remission. Glucagon-like peptide-1 receptor agonists (GLP1-RAs) have demonstrated significant metabolic benefits for patients with type 2 diabetes mellitus (T2DM) and obesity. Hence, GLP1-RAs may improve clinical outcomes in patients with IBD, especially those with obesity. The objective was to systematically evaluate the impact of GLP1-RAs on clinical outcomes in patients with IBD.
METHODS: A comprehensive literature search was performed using the databases PubMed, Embase, Web of Science, and Cochrane Library from inception to March 15, 2025. Studies reporting outcomes …