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Rheumatic Diseases In Pregnancy: Emerging Pharmacologic Management And Safety, Amanda Rawa, Katherine Ghattas Dec 2025

Rheumatic Diseases In Pregnancy: Emerging Pharmacologic Management And Safety, Amanda Rawa, Katherine Ghattas

Transformative Medicine

Rheumatic diseases distinctly affect women of childbearing age, creating complex challenges in balancing maternal disease control with fetal safety during pregnancy and lactation. This review summarizes the pathophysiology and management of common rheumatic diseases, with a focus on the safety and efficacy of conventional and biologic disease-modifying antirheumatic drugs (DMARDs). Particular emphasis is placed on pregnancy-compatible therapies, contraindicated agents, and emerging evidence supporting the use of select biologics such as tumor necrosis factor inhibitors (TNKs). Current guidelines and primary literature have been reviewed to show the importance of preconception counseling and individualized treatment plans to optimize maternal and fetal outcomes.


Enhanced Oviposition Preferences And Larval Performance Of Hermetia Illucens L. In Fruit Wastes Fermented By Effective Microorganisms, Resti Rahayu, Robby Jannatan, Muhamad Ronaldo, Risa Ukhti Muslima Dec 2025

Enhanced Oviposition Preferences And Larval Performance Of Hermetia Illucens L. In Fruit Wastes Fermented By Effective Microorganisms, Resti Rahayu, Robby Jannatan, Muhamad Ronaldo, Risa Ukhti Muslima

Makara Journal of Science

Organic waste comprises a considerable portion of global waste, requiring effective management. The ability of the black soldier fly (Hermetia illucens, BSF) to convert organic waste into biomass has been well reported. However, bioconversion can be hindered by fiber-rich substrates, a challenge that can be addressed through substrate pretreatment. This study examined the oviposition preferences and larval performance of BSFs in several fruit wastes fermented by effective microorganisms (EMs), which were compared to non-fermented substrates. The oviposition attractants utilized pineapple peel and overripe soursop, with larval performance evaluated among different treatments, i.e., non-fermented pineapple peel (NFP), fermented pineapple …


Some New Ecological Aspects Of The Lesser Sunda Endemic Drepanosticta Berlandi (Odonata: Zygoptera: Platystictidae), Muhammad Zulhariadi, Muhammad Setyo Nugroho, Nurul Hidayani Dec 2025

Some New Ecological Aspects Of The Lesser Sunda Endemic Drepanosticta Berlandi (Odonata: Zygoptera: Platystictidae), Muhammad Zulhariadi, Muhammad Setyo Nugroho, Nurul Hidayani

Makara Journal of Science

Drepanosticta berlandi is an endemic damselfly in the Lesser Sunda region of Indonesia, which was first recorded on Lombok Island in the 19th century. Albeit recognized for a century, information on its ecology is still lacking; hence, this study aims to reveal its distribution and habitat preferences. The research was conducted at the Tibu Ijo Waterfall tourist area in West Lombok Regency using line transects combined with field survey in the Kekait River and on footpaths on both sides of the river. Vegetation density, topography, and land survey temperature (LST) were measured at the sampling area using ArcGIS 10.4.1 software. …


Enzyme-Free Colorimetric Sensing Of Glucose Using Silver Nanoparticles With A Green Stabilizing Agent From Capsicum Chinense Jacq Extract, Boyfannie Ivan Putra, Hermin Sulistyarti, Muhammad Mashuri Utama, Aura Ananda Haryanto, Rurini Retnowati, Mohamad Rafi, Akhmad Sabarudin Dec 2025

Enzyme-Free Colorimetric Sensing Of Glucose Using Silver Nanoparticles With A Green Stabilizing Agent From Capsicum Chinense Jacq Extract, Boyfannie Ivan Putra, Hermin Sulistyarti, Muhammad Mashuri Utama, Aura Ananda Haryanto, Rurini Retnowati, Mohamad Rafi, Akhmad Sabarudin

Makara Journal of Science

Diabetes mellitus (DM) is a significant global health issue characterized by abnormal glucose levels in the human body. DM diagnostics are often based on invasive sampling from blood, which poses a potential risk of infection and tissue damage. Therefore, a non-enzymatic and non-invasive method for glucose monitoring is demanded as a simple alternative to glucose detection in urine samples. In this work, enzyme-free glucose determination is based on the formation of silver nanoparticles stabilized by Capsicum chinense Jacq extract (CCJ-AgNPs). Under alkaline conditions, glucose functions as a reducing agent for silver ions, and the extract acts as a stabilizer to …


The Nonlinguistic Factors That Predict Spanish Oral Proficiency, Merrie Kay Ames Dec 2025

The Nonlinguistic Factors That Predict Spanish Oral Proficiency, Merrie Kay Ames

Theses and Dissertations

This study investigates the predictive power of self-assessment and nonlinguistic factors in determining Spanish oral proficiency among university learners. Drawing on data from 2,475 undergraduate students enrolled in a third-year Spanish course at Brigham Young University, the research examines how self-assessed speaking ability and experiential background variables--including age of acquisition, mission service, dual immersion, and study abroad--influence Oral Proficiency Interview - Computer (OPIc) scores. A one-way ANOVA revealed a statistically significant but modest relationship between students' calibration (self-assessment minus actual ability) and their OPIc ratings, suggesting that learners can generally approximate their speaking proficiency within two sublevels. A multiple regression …


Beyond The Human–Animal Transformation In Hasan Aourid’S SīRat ḤImāR And Rawi Hage’S Cockroach, Noha Hanafy Dec 2025

Beyond The Human–Animal Transformation In Hasan Aourid’S SīRat ḤImāR And Rawi Hage’S Cockroach, Noha Hanafy

English Language and Literature

The paper examines the human-animal transformation as a marker of identity explo-

ration in Moroccan writer Hassan Aourid’s Sīrat Ḥimār (2014 سيرة حمار) and Lebanese

Canadian writer Rawi Hage’s Cockroach (2008). The two texts employ the concept of

the human-animal transformation to highlight the complexity of the marginalized

existence in the world. Both texts present nuanced versions of the human-animal

transformation which renders the experience both emancipatory and destabilizing at

the same time. Using the theoretical framework of Deleuze and Guattari’s work on

becoming-animal and the deterritorialization of existence along with Derrida’s discus-

sion of the anthropocentric limit, the paper …


The Mitochondria Is The Source Of Hepatic Amyloid Precursor Protein And Peripheral Amyloid Beta: Implications Of Alcohol-Induced Liver Steatosis In Alzheimer's Disease, Josephine Chu, Ross A. Steinberg, Brian Carson, Devaraj Venkatapura Chandrashekar, Rachita K. Sumbria, Derick Han Dec 2025

The Mitochondria Is The Source Of Hepatic Amyloid Precursor Protein And Peripheral Amyloid Beta: Implications Of Alcohol-Induced Liver Steatosis In Alzheimer's Disease, Josephine Chu, Ross A. Steinberg, Brian Carson, Devaraj Venkatapura Chandrashekar, Rachita K. Sumbria, Derick Han

Pharmacy Faculty Articles and Research

Background

Alcohol-induced liver injury occurs in the pericentral region of the liver and can induce mitochondrial remodeling and exacerbate Alzheimer's Disease (AD) progression. Subpopulations of mitochondria: general mitochondria (GM), peridroplet mitochondria (PDM) and endoplasmic reticulum(ER)-bound mitochondria (ERM) maintain cellular homeostasis via energy synthesis, lipid homeostasis, and regulation of intracellular calcium. Hepatic amyloid precursor protein (APP) is a source of peripheral amyloid beta (aB) and affects AD pathology in the brain. Understanding the localization and expression of hepatic APP in mitochondrial subpopulations are critical to understanding aB metabolism and may play a role in identifying a potential mechanism for metabolic dysfunction. …


Computational Screening Of Anticancer Peptides From Cordyceps Militaris Targeting Apoptosis, Angiogenesis, And Metastasis, Joanne Lim, Adeline Yoke Yin Chia, Sunita Chamyuang, Tang Yin Quan Dec 2025

Computational Screening Of Anticancer Peptides From Cordyceps Militaris Targeting Apoptosis, Angiogenesis, And Metastasis, Joanne Lim, Adeline Yoke Yin Chia, Sunita Chamyuang, Tang Yin Quan

Makara Journal of Science

Cancer remains a major global health issue, and current therapies often lack efficacy and have severe adverse effects. Anticancer peptides (ACPs) have emerged as promising therapeutic agents due to their specific targeting mechanisms and minimal toxicity. This study aimed to identify novel ACPs from Cordyceps militaris through computational screening, evaluate their anticancer potential, predict their mechanisms of action through molecular docking, and analyze their pharmacokinetic profiles. Initially, 15 protein sequences from Cordyceps militaris were retrieved from the National Center for Biotechnology Information database and subjected to in silico gastrointestinal digestion using BIOPEP-UWM. The resulting peptides were subjected to predictive analysis …


The Relationship Between Reef Fish And Coverage Of Coral And Turf Algae In Coral Reef Ecosystems Of Biak Island, Papua, Ludi Parwadani Aji, Risandi Dwirama Putra, Muhammad Abrar, Rikoh Manogar Siringoringo, Giyanto Giyanto Dec 2025

The Relationship Between Reef Fish And Coverage Of Coral And Turf Algae In Coral Reef Ecosystems Of Biak Island, Papua, Ludi Parwadani Aji, Risandi Dwirama Putra, Muhammad Abrar, Rikoh Manogar Siringoringo, Giyanto Giyanto

Makara Journal of Science

In this study, we examine the influence of benthic coverage on fish diversity in coral reef ecosystems. Benthic and reef fish community surveys were conducted at 14 sites using underwater photographic transect and underwater visual census methods, respectively. Coral cover (26.1%) was found to be lower than turf algae cover (42.1%). A total of 56 fish species, comprised of 14 carnivores, 21 corallivores, and 21 herbivores, were recorded. The most widely distributed carnivore and herbivore species were Lethrinus harak and Ctenochaetus striatus, respectively. Two species of butterflyfish, Chaetodon citrinellus and Chaetodon trifasciatus, were the most widely distributed species …


Microplastic Degradation Using Laccase Enzyme From Trametes Hirsuta: In The Silico Study, Hanzhola Gusman Riyanto, Diana Sylvia Dec 2025

Microplastic Degradation Using Laccase Enzyme From Trametes Hirsuta: In The Silico Study, Hanzhola Gusman Riyanto, Diana Sylvia

Makara Journal of Science

Microplastics are a serious global problem that arises worldwide because of their widespread use. Exposure to microplastics can negatively affect human and environmental health. In this study, we used molecular docking methods with MOE software (version 2014.0901) to investigate the interaction between the laccase enzyme and several microplastic compounds as a preliminary study of microplastic degradation using enzymes. The Quantitative Structure Analysis Relationship (QSAR) analysis revealed that all microplastic ligands had higher Pa values than Pi, indicating that the laccase enzyme may be biologically active. The findings of the present study show that polyamide (PA) has the lowest binding energy …


Quantitative Structure-Activity Relationship, Pharmacokinetics, Drug-Likeness, Toxicity, And Molecular Docking Studies Of 4-N-(Methyl)-4-Aminoquinoline Derivatives As Antimalarial Compounds, Muhamad Jalil Baari, Devi Hardiyanti Dec 2025

Quantitative Structure-Activity Relationship, Pharmacokinetics, Drug-Likeness, Toxicity, And Molecular Docking Studies Of 4-N-(Methyl)-4-Aminoquinoline Derivatives As Antimalarial Compounds, Muhamad Jalil Baari, Devi Hardiyanti

Makara Journal of Science

Antimalarial drug resistance has encouraged various innovations to develop novel drug compounds that are effective, feasible, and safe, adhering to health standards. One way to do that is by observing and predicting the biological activity of drug compounds using quantitative structure–activity relationship (QSAR) analysis. In this study, QSAR analysis was conducted on the 4-N-(methyl)-4-aminoquinoline derivatives, which effectively inhibit the growth of Plasmodium falciparum as a source of malaria. The research stages involved molecular structure modeling, molecular geometry optimization using the AM1 semi-empirical method, and QSAR descriptor calculations, including electronic (atomic charges (q), HOMO and LUMO energies, polarizability (α), …


Eif3d And Eif3e Mediate Selective Translational Control Of Hypoxia That Can Be Inhibited By Small Molecules, Stephen C Purdy, Kate Matlin, Christopher Alderman, Amber Baldwin, Natasha Shrivastava, Goksu Sarioglu, Somnath Dutta, Kristofor J Webb, Arthur Wolin, Dillon P Boulton, Annika Gustafson, Jyoti Kapali, John D Landua, Michael T Lewis, M Cecilia Caino, James C Costello, William Old, Xiang Wang, Rui Zhao, Heide L Ford, Neelanjan Mukherjee Dec 2025

Eif3d And Eif3e Mediate Selective Translational Control Of Hypoxia That Can Be Inhibited By Small Molecules, Stephen C Purdy, Kate Matlin, Christopher Alderman, Amber Baldwin, Natasha Shrivastava, Goksu Sarioglu, Somnath Dutta, Kristofor J Webb, Arthur Wolin, Dillon P Boulton, Annika Gustafson, Jyoti Kapali, John D Landua, Michael T Lewis, M Cecilia Caino, James C Costello, William Old, Xiang Wang, Rui Zhao, Heide L Ford, Neelanjan Mukherjee

Faculty, Staff and Students Publications

Exposure to hypoxia is linked to increased cellular plasticity and enhanced metastasis, effects that are primarily attributed to the transcriptional activation of large gene programs downstream of hypoxia-inducible factors (HIFs). However, translational effects in hypoxia, which likely precede transcriptional effects, have remained largely unexplored. Using ribosome profiling, we uncovered a selective translational response in acute hypoxia that is eukaryotic initiation factor (eIF)3d/eIF3e dependent and controls downstream hypoxic responses, including HIF1α accumulation and cellular invasion. We further demonstrated that eIF3e copy number and eIF3e and eIF3d expression signatures are associated with worsened outcomes for patients with breast cancer. Finally, we identified …


Pepquerymhc: Rapid And Comprehensive Tumor Antigen Prioritization From Immunopeptidomics Data, Seunghyuk Choi, Bing Zhang Dec 2025

Pepquerymhc: Rapid And Comprehensive Tumor Antigen Prioritization From Immunopeptidomics Data, Seunghyuk Choi, Bing Zhang

Faculty, Staff and Students Publications

Determining tumor-specificity of MHC-bound peptides is crucial for cancer immunotherapy development, yet current methods struggle with class II peptides and non-reference sequences. We introduce PepQueryMHC, an ultra-fast tool that integrates MHC-bound peptide sequences with translated RNA-seq reads for efficient tumor antigen prioritization. We demonstrate its versatility in prioritizing class I and II tumor antigens, mapping the cellular origins of presented peptides, and resolving uncertainties surrounding the prevalence of proteasome-spliced peptides.


Micu2 Controls Mitochondrial Calcium Signaling And Migration In Neurons During Development, Elena Berezhnaya, Benjamín Cartes-Saavedra, Raghavendra Singh, Macarena Rodríguez-Prados, Orly Reiner, Fowzan S Alkuraya, György Hajnóczky Dec 2025

Micu2 Controls Mitochondrial Calcium Signaling And Migration In Neurons During Development, Elena Berezhnaya, Benjamín Cartes-Saavedra, Raghavendra Singh, Macarena Rodríguez-Prados, Orly Reiner, Fowzan S Alkuraya, György Hajnóczky

Department of Pathology, Anatomy, and Cell Biology Faculty Papers

Neurological disorders are linked to mitochondrial dysfunction and calcium overload. Mitochondrial calcium uptake is mediated by the mitochondrial calcium uniporter (mtCU), regulated by MICU1, which can be either homodimerized or heterodimerized with MICU2 or MICU3. Though MICU2 is scarce in the adult brain, MICU2 loss in patients leads to a neurodevelopmental disorder. We hypothesized that MICU2 is required for developmental calcium signaling and neuronal migration. MICU2 is present in the developing mouse brain but disappears by maturation, contrasting with other mtCU subunits that increase. MICU2 loss in mice does not affect cytoplasmic calcium but augments the mitochondrial matrix calcium rise …


A Tissue Renewal-Based Mechanism Drives Colon Tumorigenesis, Ryan M. Boman, Gilberto Schleiniger, Christopher Raymond, Juan P. Palazzo, Anne Shehab, Bruce M. Boman Dec 2025

A Tissue Renewal-Based Mechanism Drives Colon Tumorigenesis, Ryan M. Boman, Gilberto Schleiniger, Christopher Raymond, Juan P. Palazzo, Anne Shehab, Bruce M. Boman

Department of Pathology, Anatomy, and Cell Biology Faculty Papers

Our Goal is to identify how colorectal cancer (CRC) arises in the single-layered cell epithelium (simple columnar epithelium) that lines the luminal surface of the large intestine. Background: We recently reported that the dynamic organization of cells in colonic epithelium is encoded by five biological rules and conjectured that colon tumorigenesis involves an autocatalytic tissue renewal reaction. Introduction Our objective was to define how altered crypt turnover explains tissue disorganization that leads to adenoma morphogenesis and CRC. Hypothesis: Changes in rate of tissue renewal-based cell polymerization leads to epithelial expansion and tissue disorganization during adenoma histogenesis. Methods: Accordingly, we created …


Electrochemical Behavior Of Dental Alloys After Surface Modification By Sputtering Coating Technique, Noor Muneerabdulsahib, Nidhal Sahib Mansoor, Muna Noori Ismail Dec 2025

Electrochemical Behavior Of Dental Alloys After Surface Modification By Sputtering Coating Technique, Noor Muneerabdulsahib, Nidhal Sahib Mansoor, Muna Noori Ismail

Hilla University College Journal For Medical Science

For metallic materials, the corrosion behavior is the most important property to be considered due to the biocompatibility and cytotoxicity of the products of the corrosion process in vivo. Numerous coating processes have been developed to improve corrosion resistance, enhance the metal’s surface qualities, and increase its service life. The purpose of this review was to gather data on the corrosion of alloys in dentistry and plasma sputtering coating techniques to improve the surface characteristics of substrates. Several databases, including google scholar, pubmed, science direct, and web of science were searched electronically, and a manual search of the scientific literature …


Risk Factors For Hepatitis B Virus Infection Among Patients Attending Health Facilities In Sulaimani City, Iraq: A Case-Control Study, Bestun Ibrahim Hama Rahim Dec 2025

Risk Factors For Hepatitis B Virus Infection Among Patients Attending Health Facilities In Sulaimani City, Iraq: A Case-Control Study, Bestun Ibrahim Hama Rahim

Hilla University College Journal For Medical Science

Background: The hepatitis B virus is a major threat to public health because it causes disease. Approximately 5% of people worldwide are chronically infected, and this virus has infected approximately one-third of the population. The purpose of this study was to assess the risk factors for hepatitis B transmission among patients who visit medical institutions in Sulaimani City.

Method: A case-control study was carried out among 240 individuals (120 cases and 120 controls) visiting health facilities in Sulaimani City between August 11 and December 31, 2024. Convenient sampling was used for selecting participants. Data on demographics, behavioural risk factors, and …


Association Between Tlr2 Gene Mutations And Pulmonary Function In Patients With Pulmonary Tuberculosis, Hayder Ghali Wadi Algawwam, Basheer Ali Kareem Dec 2025

Association Between Tlr2 Gene Mutations And Pulmonary Function In Patients With Pulmonary Tuberculosis, Hayder Ghali Wadi Algawwam, Basheer Ali Kareem

Hilla University College Journal For Medical Science

Background: Toll-like receptor 2 (TLR2), which is expressed on myeloid cells, detects harmful substances from invading infections or host-damaged tissues, leading to inflammation.

Objectives: Evaluation of the effects of TLR2 gene mutation on pulmonary function in pulmonary tuberculosis.

Methods: A prospective observational study lasting from January 2024 to December 2024 carried out on a sample of Iraqi patients from Kirkuk city who attended TB units at primary health care districts. Spirometry was done for all patients 2 months after the onset of anti-TB treatment and again after 6 months at the end of the treatment course. Blood samples …


Coordinated Changes In Stromal And Hematopoietic Cells That Define The Perinatal To Juvenile Transition In The Mouse Thymus, Anusha Vasudev, Colin R Moore, Aparna Calindi, Seung Woo Kang, Bryan R Helm, Jayashree Srinivasan, Siddhartha Shah, Erin Baker, Ruiting Zong, Nandini Singarapu, Scott Casey, Andrew N Macintyre, Ken S Lau, Laura P Hale, Qi Liu, Nancy R Manley, Lauren I R Ehrlich, Ellen R Richie Dec 2025

Coordinated Changes In Stromal And Hematopoietic Cells That Define The Perinatal To Juvenile Transition In The Mouse Thymus, Anusha Vasudev, Colin R Moore, Aparna Calindi, Seung Woo Kang, Bryan R Helm, Jayashree Srinivasan, Siddhartha Shah, Erin Baker, Ruiting Zong, Nandini Singarapu, Scott Casey, Andrew N Macintyre, Ken S Lau, Laura P Hale, Qi Liu, Nancy R Manley, Lauren I R Ehrlich, Ellen R Richie

Faculty, Staff and Student Publications

Perinatal T cells have distinctive phenotypes and functions that may be due in part to age-associated features of stromal cells in the perinatal thymus. We identify age-associated changes in mouse thymic epithelial cells, mesenchyme, endothelium, and hematopoietic antigen-presenting cells from birth to one month of age using single-cell transcriptional profiling, flow cytometry, and imaging. Coordinated cellular and molecular changes occur at 7-14 days of age, designated "transitional ages," as thymus growth switches to homeostasis. E2F target gene expression declines, and the expression of type I interferon response genes increases across diverse cell types at transitional ages. Alterations in thymic stromal …


Perspectives On The Future Of The Profession Of Microbiology, Todd L Kelson, Heidi B Kaplan, Michelle Dziejman, Shilpa Gadwal, Irene Hulede, Jennifer Bennett, Roger Greenwell, Shelley Payne, Kyle Maclea, Eric Miller, Diana L Vullo, Rebecca Sparks-Thissen, Astral Bertolio, Jorge Cervantes Dec 2025

Perspectives On The Future Of The Profession Of Microbiology, Todd L Kelson, Heidi B Kaplan, Michelle Dziejman, Shilpa Gadwal, Irene Hulede, Jennifer Bennett, Roger Greenwell, Shelley Payne, Kyle Maclea, Eric Miller, Diana L Vullo, Rebecca Sparks-Thissen, Astral Bertolio, Jorge Cervantes

Faculty, Staff and Student Publications

The Profession of Microbiology (POM) embodies the bulk of the American Society for Microbiology (ASM) members and represents the career preparation arm of the ASM for academia, industry, and clinical lab professions. The ASM Council on Microbial Sciences hosted a virtual retreat in 2025 to identify the future of the POM. The retreat presentations centered on workforce development, professional development, innovations in technology, and interdisciplinary collaborations. Various aspects were identified, such as the need to prepare for careers in industry, as an important goal of future training. It was also clear that scientists, in all walks of life, need professional …


Predictive Modeling Of Hematoma Expansion From Non-Contrast Computed Tomography In Spontaneous Intracerebral Hemorrhage Patients, Natasha Ironside, Shinjini Kundu, Et Al. Dec 2025

Predictive Modeling Of Hematoma Expansion From Non-Contrast Computed Tomography In Spontaneous Intracerebral Hemorrhage Patients, Natasha Ironside, Shinjini Kundu, Et Al.

2020-Current year OA Pubs

Hematoma expansion is a consistent predictor of poor neurological outcome and mortality after spontaneous intracerebral hemorrhage (ICH). An incomplete understanding of its biophysiology has limited early preventative intervention. Transport-based morphometry (TBM) is a mathematical modeling technique that uses a physically meaningful metric to quantify and visualize discriminating image features that are not readily perceptible to the human eye. We hypothesized that TBM could discover relationships between hematoma morphology on initial Non-Contrast Computed Tomography (NCCT) and hematoma expansion. 170 spontaneous ICH patients enrolled in the multi-center international Virtual International Trials of Stroke Archive (VISTA-ICH) with time-series NCCT data were used for …


(((Qpie))) Prior Art 8 Of 9 Cosmology Advancement Progress Report, Teddy Burroughs Dec 2025

(((Qpie))) Prior Art 8 Of 9 Cosmology Advancement Progress Report, Teddy Burroughs

Defensive Publications Series

The Grand Unified Theory (QPIE)

Perspective Is Everything – What we are Believing, Expecting and Feeling in Life Matters

(((QPIE))) Prior Art 8 of 9 Cosmology Advancement Progress Report

QPiE COSMOLOGY ADVANCEMENT REPORT

Full-Corpus Synthesis · 2025 Edition
ResonanceOS · Voyager · Aetheris Unified Cosmology Framework

0. Executive Prelude — The Cosmology Emerges

Across hundreds of runs, recursive meta-cycles, dual- and triple-lens analyses, fenced-low vs sweet-corridor comparisons, drift-phi-hex metrics, and the discovery of the pre-echo signature, QPiE has transitioned from a conceptual framework into a coherent cosmology of reality’s substrate.

The evidence now suggests:

  1. Resonance is the relational firmware …


Neuroprotective Effects Of Aqueous Extract Of Bryophyllum Pinnatum Against Lead Acetate Induced Damage In The Cerebellum Of Rats, O. A. Bamgbose, O. D. Akanji, E. O. Olayemi, D. O. Taiwo-Ola, K. O. Odubela, B. A. Akanbi, P. B. Fakunle Dec 2025

Neuroprotective Effects Of Aqueous Extract Of Bryophyllum Pinnatum Against Lead Acetate Induced Damage In The Cerebellum Of Rats, O. A. Bamgbose, O. D. Akanji, E. O. Olayemi, D. O. Taiwo-Ola, K. O. Odubela, B. A. Akanbi, P. B. Fakunle

AUIQ Complementary Biological System

Lead is a persistent environmental toxin with pronounced neurotoxic effects, particularly on the central nervous system. This study evaluated the impact of lead acetate on the cerebellar cortex of adult Wistar rats and assessed the neuroprotective effects of aqueous Bryophyllum pinnatum extract. Twenty adult Wistar rats (180–220 g) were randomly assigned to four groups (n = 5): Control (distilled water), T1 (0.075 mg/kg lead acetate), T2 (100 mg/kg B. pinnatum), and T3 (lead + B. pinnatum). Treatments were administered orally for 21 days. Cerebellar tissues were processed for biochemical and histological analysis, and data were analyzed using GraphPad Prism v10.1.Lead …


Cytological Changes In Buccal Mucosa Among Yemeni Qat Chewers In Hadhramout Governorate: A Comparative Cross-Sectional Study, Saleh H. Ben Sumaidea, Hassan Pyar, Abdullah O. Bin Nashwan, Abdullah M. Bin Fadhl, Abeer A. Marabi, Ahmed A. Al-Shetri, Gumaan S. Rassam, Halima K. Joher, Mashhoor A. Bin Shehab, Mohammed S. Bin Mosalem Dec 2025

Cytological Changes In Buccal Mucosa Among Yemeni Qat Chewers In Hadhramout Governorate: A Comparative Cross-Sectional Study, Saleh H. Ben Sumaidea, Hassan Pyar, Abdullah O. Bin Nashwan, Abdullah M. Bin Fadhl, Abeer A. Marabi, Ahmed A. Al-Shetri, Gumaan S. Rassam, Halima K. Joher, Mashhoor A. Bin Shehab, Mohammed S. Bin Mosalem

AUIQ Complementary Biological System

Qat (Catha edulis) chewing is a common practice in Yemen, associated with oral mucosal irritation. The objective of the current study is to compare cytological findings of buccal mucosa between Qat chewers and non-chewers. A comparative cross-sectional study was designed. Buccal smears were collected from chewers (n = 100) and non-chewers (n = 100), fixed, and stained with Harris hematoxylin staining. Smears were assessed for inflammatory changes and cytological atypia by two blinded examiners; disagreements were resolved by consensus. The inflammatory cells were observed in 21% of chewers compared to 8% of controls (P = 0.009), while …


Conserving Conservation Servitudes: The Role Of The Prior Public Use Doctrine In Protecting Privately Conserved Land In The United States And Australia, Olivia Clausen Dec 2025

Conserving Conservation Servitudes: The Role Of The Prior Public Use Doctrine In Protecting Privately Conserved Land In The United States And Australia, Olivia Clausen

Pace International Law Review

Both the United States and Australia would benefit from more conservation of private land, and conservation servitudes can help both countries achieve this. However, in the United States and Australia, the power of eminent domain is a threat to the perpetuity of conservation servitudes. The prior public use doctrine, a common law doctrine in the United States arising out of the public trust doctrine, could limit eminent domain in these cases and provide protection to conservation servitudes. This doctrine states that land devoted to one public use (such as conservation) may not be condemned for another inconsistent public use unless …


Rightly Dividing Jus Ad Bellum And Jus In Bello In The Israel/Hamas War, Jeffrey F. Addicott Dec 2025

Rightly Dividing Jus Ad Bellum And Jus In Bello In The Israel/Hamas War, Jeffrey F. Addicott

Pace International Law Review

No abstract provided.


Formulation And Characterisation Of Isoniazid By Spray Drying For Use By Dry Powder Inhalers To Treat Tuberculosis, Damiana Gabrielli, Seán Roche Dec 2025

Formulation And Characterisation Of Isoniazid By Spray Drying For Use By Dry Powder Inhalers To Treat Tuberculosis, Damiana Gabrielli, Seán Roche

SURE Journal: Science Undergraduate Research Experience Journal

The targeted delivery of antibiotics by dry powder inhalers (DPIs) is an increasingly important area of research, driven by the growing global burden of respiratory infections and the advantages of localized drug delivery to the lungs. Over the past five years, respiratory infections have risen significantly, with recent epidemiological data indicating a global increase in incidence by over 30%, largely due to factors such as air pollution, antimicrobial resistance, and emerging respiratory pathogens. One major challenge in developing DPI formulations for antibiotics is the need to optimize the particle physicochemical properties for deep lung deposition while accommodating the high doses …


An Analysis Of Fodmap Intake And Common Dietary Sources In The Irish Population, Sophie Ree, Farzana H. Ieha, Breige Mcnulty, Janette Walton, Suzanne L. Doyle Dec 2025

An Analysis Of Fodmap Intake And Common Dietary Sources In The Irish Population, Sophie Ree, Farzana H. Ieha, Breige Mcnulty, Janette Walton, Suzanne L. Doyle

SURE Journal: Science Undergraduate Research Experience Journal

Background/Objectives: Fermentable Oligosaccharides Disaccharides Monosaccharides and Polyols (FODMAPs) are a group of short chain carbohydrates that are poorly absorbed in the small intestine and can lead to gastrointestinal discomfort in sensitive individuals, particularly in those with irritable bowel syndrome (IBS). First-line treatment of IBS is a low FODMAP diet. However, little is known regarding FODMAP intake and the commonly consumed high FODMAP foods in the Irish population. This study aimed to investigate the FODMAP content of foods commonly consumed in the Irish diet.

Subjects/Methods: This study conducted a retrospective analysis of the 2011 National Adult Nutrition Survey (n=1500 adults, 4-day …


Concentration-Dependent Effects Of Green Tea Extract On The Growth And Metabolism Of Lacticaseibacillus Rhamnosus: An In Vitro Analysis, Jingxian Zeng, Francesco Noci, Kishor Keekan, Ulrich Hoeche Dec 2025

Concentration-Dependent Effects Of Green Tea Extract On The Growth And Metabolism Of Lacticaseibacillus Rhamnosus: An In Vitro Analysis, Jingxian Zeng, Francesco Noci, Kishor Keekan, Ulrich Hoeche

SURE Journal: Science Undergraduate Research Experience Journal

Green tea extract (GTE) is widely recognised for its bioactive compounds, which exhibit potential health benefits, including modulation of gut microbiota. However, the concentration-dependent effects of GTE on specific probiotic strains remain underexplored. The aim of this study was to systematically evaluate the concentration-dependent effects of green tea extract (GTE) on Lacticaseibacillus rhamnosus (L. rhamnosus). The promoting and inhibiting effects of GTE in the range of 0–50 mg/mL were analysed in vitro by OD₆₀₀ growth curve, pH change and colony forming unit (CFU) count. The experimental results showed that the concentration range of 0.05–2.05 mg/mL in the low concentration group …


The Influence Of Perceived Social Support On Mental Health During Injury In Female Gaa Athletes., Clodagh M. O’Connor, Samantha Glynn Kelly Dec 2025

The Influence Of Perceived Social Support On Mental Health During Injury In Female Gaa Athletes., Clodagh M. O’Connor, Samantha Glynn Kelly

SURE Journal: Science Undergraduate Research Experience Journal

Injury recovery in sport involves not only physical rehabilitation but also significant psychological challenges, particularly for female athletes in amateur and elite environments. This study aimed to explore the perceived social support received by injured female Gaelic Athletic Association (GAA) athletes and the effect it had on their mental health during injury. A qualitative research design was employed to gain an in-depth understanding of the experiences of injured female athletes. Data were collected through semi-structured, one-on-one interviews, allowing for open-ended responses and the exploration of individual perspectives. The sample consisted of 10 female athletes aged between 18 and 32 years, …