Digital Commons Network^™

Image-Based Meta- And Mega-Analysis (Ibmma): A Unified Framework For Large-Scale, Multi-Site, Neuroimaging Data Analysis, Jacklynn M. Fitzgerald

Psychology Faculty Research and Publications

The increasing scale and complexity of neuroimaging datasets aggregated from multiple study sites present substantial analytic challenges, as existing statistical analysis tools struggle to handle missing voxel-data, suffer from limited computational speed and inefficient memory allocation, and are restricted in the types of statistical designs they are able to model. We introduce Image-Based Meta- & Mega-Analysis (IBMMA), a novel software package implemented in R and Python that provides a unified framework for analyzing diverse neuroimaging features, efficiently handles large-scale datasets through parallel processing, offers flexible statistical modeling options, and properly manages missing voxel-data commonly encountered in multi-site studies. IBMMA successfully …

Imaging Features Of High-Grade Astrocytoma With Piloid Features: A Single Center Case Series, Heba Al Qudah, Jackson D Hamilton, Maria A Gubbiotti, Ahmed Msherghi, Hamza A Salim, Sahar Alizada, Ho-Ling Liu, Vinodh A Kumar, Max Wintermark, Rami W Eldaya

Faculty, Staff and Student Publications

High-grade astrocytoma with piloid features (HGAP) is a recently described IDH-wildtype tumor with limited literature describing its imaging features. We present our institution's experience and the largest imaging-focused cohort of HGAP reported to date, offering a comprehensive analysis of MRI features of seventeen intracranial and one spinal HGAP, while introducing novel imaging features that have not been previously described. These include focal areas of diffusion restriction, surrounding spiculated, finger-like enhancement and increased perfusion metrics. Additionally, we highlight imaging features of HGAP arising in patients with Neurofibromatosis Type 1, such as intraventricular tumor spread, unusual temporal lobe location and multifocal presentation.

Advancements In Understanding Spasticity: A Neuromusculoskeletal Modeling Perspective, Mohammad S Shourijeh, Argyrios Stampas, Shuo-Hsiu Chang, Radha Korupolu, Gerard E Francisco

Faculty, Staff and Student Publications

Spasticity, a complex consequence of upper motor neuron lesions, poses challenges for clinical assessment due to its neural and mechanical origins. Traditional scales like the Modified Ashworth and Tardieu Scales provide subjective, context-limited insights, often missing spasticity's dynamic nature. Neuromusculoskeletal (NMS) modeling offers objective, quantitative insights by integrating patient-specific muscle-tendon properties, reflex dynamics, and multi-joint biomechanics. This scoping review examines advancements in spasticity modeling, comparing mechanical, neurological, and integrated approaches, and their applications in conditions like cerebral palsy and stroke. We highlight barriers to clinical translation, including computational demands and regulatory challenges, and propose future directions, such as real-time simulation …

The Impact Of Arginase1, Malondialdehyde Levels And The Activity Of Glutathione S-Transferase On The Development And Progression Of Diabetic Retinopathy In Some Iraqi Patients, Maha Faris Yaseen, Fayhaa M. Khaleel

Baghdad Science Journal

Diabetic retinopathy (DR) is the major cause of blindness due to microvascular damage from high blood glucose and lipid levels. Arginase1 is an enzyme that regulates β-cell activities, insulin resistance, and vascular complications, inflammatory responses, and oxidative stress. This study aimesto investigate the role of Arginase1 in Iraqi individuals with obesity, T2DM and DR and investigating the relationship with GST and MDA in the development of inflammation and oxidative stress that causes diabetic complication. This research included 120 participants: 40 obese controls, 40 diabetes Type 2 patients, and 40 diabetic retinopathy patients, aged 30–65, from both sexes. All groups …

Synthesis, Characterization And Biological Activity Studies Of New Metal Ion Complexes With Schiff Base Derived From (Z)-3-Hydrazineylidene-1-Phenylpyrazolidine And Evaluating Them As Antioxidants, Zahra Mounir Ahmed, Naser Shaalan

Baghdad Science Journal

The research includes the preparation of several complexes of the transition elements and zinc where M(II) = Co, Ni, Cu, and Zn, containing the 3d shell, with ligand (LH)was synthesized by treating the (Z)-3-hydrazineylidene-1-phenylpyrazolidine and Salicylaldehyde. Ligand (LH) was identified using FT-IR spectra,¹H-¹³C-NMR, UV-Vis spectroscopy, elemental microanalysis CHN and mass spectrometry. The complexes were studied and identified with elemental microanalysis CHN, FT-IR spectroscopy, UV-Vis spectroscopy, conductivity measurement, and magnetic sensitivity. The result showed that, these complexes were classified as homogeneous tridentate complexes with the formula [M(LH) (H₂O)₂Cl] or [M(LH)₂]. xH …

Studying The Corrosion Inhibition Ability Of Metoclopramide Drug On The Copper Surface In Seawater And Theoretical Studies, Nafeesa J. Kadhim, Ahlam M. Farhan, Rasha A. Jassim, Muna S. Sando, Hawraa M. Abdulkareem, Taghried A. Salman

Baghdad Science Journal

Protection study of the corrosion behavior of Copper surface was conducted with several concentrations of drug. Experimentally, voltammetric measurements were used to check the inhibition efficiency (% IE) in saline solution of 3.5% NaCl. The results showed an increase in the inhibition efficiency with increasing the concentration of the drug was 95.90%. Theoretical treatment of the drug in the gas phase was performed using the (hyperchem-8.07) program for molecular mechanics and semi-empirical computations. The (PM3) approach was used to determine the heat of formation (ΔH˚f), binding energy (ΔEb), and total energy (ET) for durq at 298 K. To explore the …

Determination Of Ni (Ii) By Forming A New Complex N-(4-(Dimethyl Amino) Benzylidene)-3, 5-Dinitrobenzohydrazide Nickel (Ii) Chloride, Elham N. Mezaal, Kawther Ahmed Sadiq, Maha A. Mohammed

Baghdad Science Journal

In this research, the theme for employing a simple and sensitive method is to employ a new Schiff base ligand (N'-(4-(dimethyl amino) benzylidene)-3, 5-dinitrobenzohydrazide) to estimate Ni (II) to form orange complex (N-(4-(dimethyl amino) benzylidene)-3, 5-dinitrobenzohydrazide nickel (II) chloride) in acid medium (hydrochloric acid), it gives an absorption peak at the wavelength 485 nm. The preferred conditions were studied to form the complex and obtain the highest absorbance including concentration of Schiff base ligand, the best medium for complex formation, effects of addition sequence on complex formation, the effect of temperature on the absorbance of the complex formed, and the …

Preparation, Diagnosis, Theoretical Study, Biological Evaluation And Antioxidant Assay Of Zro2 Oxide Nanoparticles Using Environmentally Friendly Method, Wafaa Fayyad Tharp, Lekaa K. Abdul Karem

Baghdad Science Journal

This research included using an environmentally friendly method to synthesize nano particles of zirconium oxide using chamomile plant extract as a reducing agent in basic medium at pH 12, and then preparing the metal oxide using various techniques such as FTIR spectroscopy, scanning and transmission electron microscopy (SEM and TEM), energy-dispersive X-ray spectroscopy (EDX) to calculate the percentages of elements. The infrared spectrum showed the appearance of spectral bands at 559 and 441 cm^–1 due to the formation of the bond between the oxygen and zirconium. Depending on AFM analysis, the average mean size of ZrO₂ Nano partials …

Spectrophotometric And Flow Injection System For Sensitive Determination Of Hesperidin And Naringenin Using Chromogenic Reagent, Ali M. Salman, Sadeem Subhi Abed

Baghdad Science Journal

Methods with high precision and sensitivity have been developed to estimate Hesperiden (HSP) and Naringenin (NAR) levels in various samples, including capsules for medicines and urine. These techniques utilize a flow injection device and an alkaline medium to perform a coupling reaction using diazotized metoclopramide (DMP) as chromogenic reagent. The utilization of the diazotized reagent of metoclopramide is regarded as an environmentally friendly chromogenic reagent. The peak absorption wavelengths for HSP and NAR are 442 nm and 416 nm, respectively, indicating that yellow dyes exhibit the most outstanding absorption at these specific wavelengths. Calibration curves were generated using a range …

Preparation, Characterization, And Evaluation Of The Antioxidant Activity Of Chitosan Nano-Particles, Sura M. Abbood, Zahraa Raheem Murshidy, Aziz Y. H. Al-Ethari

Baghdad Science Journal

Nanotechnology is considered as a modern technique which provides useful characteristics to the nanomaterial including small size with high biological activity and the possibility to obtain novel nano-biohybrids through combining efficient and safe transport carriers with biological molecules. The nanohybrid chitosan has important applications in the food industry, due to its biochemical properties, such as biocompatibility, biodegradability, non-toxicity. The goal of this research is to develop environmentally friendly, economically feasible and a simple prepared natural nanohybrid antioxidant instead of artificial one, which is a main characteristic on a food industrial scale. The sol-gel ion exchange method was used to prepare …

Mechanism Of Immunotherapeutic And Anticancer Effects Of Moringa Peregrina Seed Extract On Non-Small-Lung Cancer, Nci-H460, Cell Line, Shaymaa Fadhel Abbas Albaayit, Maryam Kamel Mohammed, Ali Muhsin Ali, Rukesh Maharjan, Lubna M. Rasoul, Rasedee Abdullah, Mohd Hezmee Mohd Noor

Baghdad Science Journal

The Moringa peregrina plant possesses various therapeutic properties. This study determined the immunomodulatory and cytotoxic activities of M. peregrina seed ethanol extract (MPSE). Based on using gas chromatography-mass spectrometry analysis MPSE is rich in flavonoids, isothiocyanate, tocopherols, triterpenoids, and phenolics compounds. The immunomodulatory effect of MPSE was determined on whole blood and polymorphonuclear (PMNs) cells and macrophages. The in vitro antiproliferative effect was determined on the non-small-cell lung cancer, NCI-H460, cell line. Real-time quantitative PCR and flow cytometry were used to determine the expression of apoptotic genes in the MPSE-treated NCI-H460 cells. MPSE significantly (p < 0.001) suppressed whole blood, PMN cells and macrophage ROS production with IC50 values of 40.3 ± 0.3, 33.0 ± 0.6, and 26.1 ± 0.43 μg/mL, respectively. MPSE …

Study The Effect Of Pseudomonas Trivialis, Isolated From Soils Subjected To High Anthropogenic Pressure, On Plant Resistance To Salt Stress, Lyudmila I. Zaynitdinova, Nikolay A. Lazutin, Rokhila N. Juraeva, Rustam B. Ergashev, Javlon J. Tashpulatov, Natal’Ya G. Akinshina, Shokhsanam A. Safarova

Baghdad Science Journal

From soils exposed to anthropogenic load, a bacterial strain resistant to pollutants was isolated and characterized. The strain was identified as Pseudomonas trivialis 381 based on morphological, cultural, physiological and biochemical characteristics, as well as MALDI-TOF and 16S rRNA analysis. Its sequence was submitted to the NCBI GenBank (OR234684.1). Studies were conducted to evaluate the influence of the strain on seed germination and plant growth qualities. Laboratory studies have shown the stimulating effect of P. trvialis 381 on tomato seeds; seeds treated with the bacterial cultural liquid increased the energy of germination and seed germination to 100% (with the control …

Isolation And Purification Of Phytosterols From Euphorbia Milii Plant Cultivated In Iraq By Phplc And Evaluation Of Anticancer Activity, Z. O. Salman, Bushra M.J. Alwash, E. J. Kadhim

Baghdad Science Journal

Combined, plant sterols and stanols, substances structurally similar to cholesterol, are referred to as phytosterols. In plants, phytosterols serve the same purposes as cholesterol does in animals and people. This study’s primary goal was to compare two different cell line types to the extracted steroid and nano-steroid. PHPLC was used to isolate the novel steroid molecule from the Euphorbia milii plant in its pure form, and FT.IR was used to confirm its identity. The chemical had a retention time of 13.87. By using the chitosan-maleic complex process, nano-steroids were created. To evaluate produced nanoparticles, the Philips PW1730 XRD instrument was …

In Vitro And In Vivo Evaluation Of Autochthonous Probiotics And Their Effects On The Mucosal Health Of Nile Tilapia (Oreochromis Niloticus), Sherilyn T. Abarra, Sahya Maulu, Sheu G. Odu-Onikosi, Taofik A. Momoh, Benjamin Eynon, Matthew Emery, Mark Rawling, Daniel L. Merrifield

School of Biological and Marine Sciences

The host microbiome is a promising source of probiotics for aquaculture species including Nile tilapia. In this study, the probiotic potential of autochthonous bacterial isolates from Nile tilapia and carp mid-intestines were screened in vitro. Two isolates (C61 and T70), closely related to Bacillus subtilis, exhibited antagonistic activity against multiple pathogen species and demonstrated multiple digestive enzyme activities. Their antagonistic activity in Aeromonas hydrophila assays remained even under simulated intestinal juice (SIJ) exposure. Subsequently, C61 (PT1) and T70 (PT2) were added to experimental diets at log 7 CFU/g of diet, and fed to Nile tilapia (5.32 ± 0.12 g) for …

Applied Research In Field Crop Pathology For Indiana, 2024, Darcy E. P. Telenko, Sujoung Shim

Purdue University Press Books

Applied Research in Field Crop Pathology for Indiana, 2024 serves as a summary of the applied field crop pathology research trials conducted in 2024 under the direction of the Purdue Field Crop Pathology program in the Department of Botany and Plant Pathology at Purdue University. In Indiana, there are more than 57,600 farms, 16,000 crop producers, and 900 certified crop advisers, Extension educators, and crop-protection industry representatives who manage more than 11.4 million crop-production acres with a total value of $6.3 billion annually. There are more than twenty diseases affecting corn, soybeans, and wheat that may decrease crop production and …

Artificial Light At Night Alters Seaweed Reproductive Phenology, Emma Moyse, Louise Firth, Tim Smyth, Thomas Davies

School of Biological and Marine Sciences

Artificial light at night (ALAN) is a growing, globally prevalent environmental stressor. It is known to disrupt biological processes across taxa and biomes, including reproductive phenology in terrestrial plants, but its potential to alter reproductive timings in marine macroalgae remains unexplored. We used reflectance spectrometry to quantitatively assess changes in receptacle ripeness of three fucoid macroalgae species at four field sites along an ALAN gradient in Plymouth Sound, UK over a six-month period. At sites with elevated ALAN (measured using Sky Quality Meters, range 16.15–18.76 mag arcsec ⁻², equivalent to 3.75 × 10 ⁻²–3.38 × 10 ⁻³ cd/m …

Unveiling Novel Bladder Cancer Associations From Multicentred Primary And Secondary Care Electronic Health Records By Machine Learning: A Case-Control Study, Xu Wang, Andrea Preston, Jonathan Aning, Shang-Ming Zhou

School of Nursing and Midwifery

ObjectiveThe rising incidence and mortality in bladder cancer (BC) underscore the importance of identifying asscociated features. Current reliance on haematuria as a primary indicator for BC proves inadequate. While mining electronic health records (EHRs) offer potential of identifying BC-related signals, traditional data-driven methods struggle with high-dimensional datasets. This study aims to uncover novel BC-associated clinical signals by developing Parsimony-driven cAtegory-balaNced binary Signal extractor for Primary Care EHRs (PanSPICE) tailored to extremely high-dimensional data linked from multi-centres.MethodsWe collected BC cases and control patients (n = 64,884) linked at patient-level from Welsh nationwide databases, yielding 48,261 features in primary care settings. The …

Multisite Assembly Of Gateway Induced Clones (Magic): A Flexible Cloning Toolbox For Use In Vertebrate Model Systems, William B Gillespie, Yuwen Zhang, Oscar E Ruiz, Juan Cerda, Joshua Ortiz-Guzman, Michelle Sherman, Williamson D Turner, Gabrielle Largoza, Lili E Mosser, Esther Fujimoto, Chi-Bin Chien, Kristen M Kwan, Benjamin R Arenkiel, W Patrick Devine, Joshua D Wythe

Duncan NRI Faculty and Staff Publications

Here, we present MultiSite Assembly of Gateway Induced Clones (MAGIC), which leverages Gateway-based recombinatorial cloning technology for rapid, modular assembly of plasmids to facilitate transgenesis in cells and vertebrate animal models. The MAGIC collection of plasmids spans a range of in vitro and in vivo uses, from tools for optically and chemically tunable gene expression, to simultaneous expression of microRNAs and fluorescent reporters, to a suite of distinct subcellular compartmental fluorescent reporters, to Cre and Dre recombinase-dependent gene expression. MAGIC system components are compatible with existing MultiSite Gateway Tol2 systems currently used in zebrafish and mammalian lentiviral and adenoviral Destination …

Characterizing The Metabolites Of The Tyrosine-Kinase Inhibitor Pexidartinib In Mouse Feces, Urine, Plasma, And Liver, Xuan Qin, Si Chen, John M Hakenjos, Jian Wang, Lei Guo, Ashish Dogra, Zhaoyong Hu, Kevin R Mackenzie, Feng Li

Faculty, Staff and Students Publications

Pexidartinib (PEX, TURALIO®), a tyrosine kinase inhibitor, is approved for treating tenosynovial giant cell tumor in adults. However, its potential to cause fatal liver injury has prompted the U.S. FDA to issue a black box warning, and the mechanisms underlying its hepatotoxicity remain largely unknown. As biotransformation may contribute to PEX-induced hepatotoxicity, understanding its metabolism is essential. Our previous research indicated that PEX forms reactive metabolites in human and mouse liver microsomes and in human hepatocytes. We investigated PEX metabolism and liver distribution in mice with a focus on metabolite characterization. Our data shows that PEX is mainly excreted into …

Generation And Characterization Of A Knockout Mouse Of An Enhancer Of Ebf3, Emily Cordova Hurtado, Janine M Wotton, Alexander Gulka, Crystal Burke, Jeffrey K Ng, Ibrahim Bah, Juana Manuel, Hillary Heins, Stephen A Murray, David U Gorkin, Jacqueline K White, Kevin A Peterson, Tychele N Turner

2020-Current year OA Pubs

Genomic studies of neurodevelopmental disorders (NDDs) have identified several relevant genomic variants. EBF3 is a gene with an excess of protein-coding de novo variants and underlies Hypotonia, Ataxia, and Delayed Development Syndrome. We previously identified noncoding de novo variants in an enhancer of EBF3 and further found enrichment of deletions of this enhancer in NDDs. In this study, we generated a novel mouse line that deletes the highly conserved, orthologous mouse region within the Rr169617 regulatory region, and characterized the molecular and phenotypic aspects of this mouse model. We found a deviation from Mendelian expectation (P=0.02) with significant depletion of …

Evaluation Of The Impact Of Coriander Sativum Extract On The Modulation Of Inflammatory And Oxidative Enzymes In Ptz Induced Epilepsy In A Rat Model, Rusul Ali Kadhim, Zahraa Saleem Manji

Maaen Journal for Medical Sciences

Background

Recurrent and spontaneous seizures are a symptom of the epilepsy. It affects up to 65 million individuals globally, with lower-income nations accounting for 80% of cases. Since medicinal plants have special therapeutic qualities, they are frequently used to manage and cure epilepsy and convulsions. Because they have fewer side effects and stronger therapeutic results, medicinal plants are becoming more and more popular worldwide as a result of increased research and clinical use. The pharmaceutical industry is now concentrating heavily on the creation of novel plant-based antiepileptic/anticonvulsant drugs

Aims of the study:

Study the role of coriander sativum extraction in …

Mental Health Concerns Counselors Should Be Aware Of When Working With Women Experiencing Infertility, Corrina Harris, Kellie Forziat-Pytel

Journal of Counselor Preparation and Supervision

Women experiencing infertility (WEI) are a unique group that rarely receives acknowledgment in the literature as such. These women encounter physical, emotional, and financial burdens throughout their infertility journey. Counseling research is limited on information addressing the experiences of WEI. This article highlights this unique group by providing an overview of the infertility journey for women. Counselors will learn the common mental health concerns to be aware of when working with WEI and examine a case example of infertility with a counselor’s approach. In addition, the article will identify the research gaps related to this population. Implications are made for …

Life Balance For Counselors-In-Training: An Interpretative Phenomenological Investigation, Corey Olver

Journal of Counselor Preparation and Supervision

Life balance is an important yet understudied construct for counselors-in-training (CITs). Pursuing a graduate degree in counseling involves an investment of time and resources that may increase stress and adversely affect CIT wellbeing. This study explores the experience of ten CITs as they navigated life balance during their education. Analysis revealed that life balance was challenging as CITs managed their educational, personal, and work demands. Key findings reveal that satisfaction with life balance is related to alignment between real and ideal activity engagement, that students made important sacrifices to maintain balance, and their educational experience contributed to life balance perception. …

In Vivo Pharmacokinetic Evaluation Of A Gastro-Retentive Triple Drug Delivery System Utilizing Natural Polymers For Enhanced Helicobacter Pylori Eradication, Edukulla Satheesh Kumar, Hindustan Abdul Ahad, Thirumalesh Naik Sugali Banoth

Bulletin of Faculty of Pharmacy Cairo University

This study evaluates the in vivo pharmacokinetics of triple-drug gastro-retentive formulation (metronidazole- Plantago ovata seed mucilage/ clarithromycin- Abelmoschus esculentus fruit mucilage/enteric-coated pantoprazole) for Helicobacter pylori eradication, with a focus on pharmacokinetic parameters (e.g., relative bioavailability vs. conventional doses) as the true contribution. In a cross over study using six rabbits, plasma concentrations of metronidazole, clarithromycin, and pantoprazole sodium were measured via High Performance Liquid Chromatography technique, and pharmacokinetic parameters were determined. A single dose of the optimized formulation (C-8) produced optimal drug levels, with a mean Cmax of 24.36 ± 0.84 μg/mL and tmax at 6 hours. The other pharmacokinetic …

Does The National Benchmark Quantitative Literacy Test Predict Performance In Stem Programmes In Commerce, Engineering And Science?, Robert N. Prince

Numeracy

In South Africa, university completion rates remain low, with only 23% of students finishing within the regulation time (three or four years). These completion rates continue to reflect racial inequalities, with ‘White’ students significantly more likely to complete degrees in professional fields such as engineering and commerce compared to their ‘African’ counterparts. To address these challenges, the South African higher education institutions, through their umbrella body, introduced the National Benchmark (NB) tests to assess students’ academic literacy skills—including quantitative literacy, academic literacy, and mathematics—to identify those most at risk of struggling with the curriculum. The NB tests aim to evaluate …

The Next Generation, Jeremiah Chin

Kentucky Law Journal

No abstract provided.

Review Of Shaker Cut-And-Fold Booklets: Unfolding The Gift Drawings Of Emily Babcock, Elizabeth De Wolfe

Communal Societies

No abstract provided.

The Emancipation Of Shakerism, Philippe Chavance

Communal Societies

No abstract provided.

Fall 2025 - Volume 35, Number 2

CompassPoint

No abstract provided.

Apocalyptic Anticipations: Mormon Millenarianism In The Early Years, Grant Underwood

Communal Societies

No abstract provided.