Digital Commons Network^™

Selective Inhibition Of Canonical Stat3 Signaling Suppresses K-Ras Mutant Lung Tumorigenesis And Reinvigorates Anti-Tumor Immunity, Michael J Clowers, Zahraa Rahal, Sung-Nam Cho, Avantika Krishna, Bo Yuan, Leticia G Hamana Zorrilla, T Kris Eckols, Moses M Kasembeli, Samuel Liu, Stephen Peng, Marco Ramos-Castaneda, Annamarie L Thompson, Carlos Ignacio Rodriguez Reyna, Katherine E Larsen, Maria T Grimaldo, Shanshan Deng, Nastaran Karimi, Cody Chou, Walter V Velasco, Melody Zarghooni, Sayan Alekseev, Luisa M Solis Soto, Edwin J Ostrin, Humam Kadara, Suhendan Ekmekcioglu, David J Tweardy, Seyed Javad Moghaddam

Faculty, Staff and Student Publications

Introduction: K-ras mutant lung adenocarcinoma (KM-LUAD) is a difficult-to-treat cancer subtype in which chronic inflammation pervades the tumor immune microenvironment (TIME). Pro-inflammatory pathways dampen the response to treatments, including immune checkpoint inhibitors, necessitating therapies that target this inflammatory signaling network in the TIME. One of the lynchpins of chronic inflammation in KM-LUAD is signal transducer and activator of transcription 3 (STAT3).

Methods: Here, we tested the anti-tumor and early immunotherapeutic efficacy of TTI-101, a selective small-molecule inhibitor of canonical STAT3 signaling, in a K-rasG12D mutant lung cancer mouse model (CC-LR).

Results: Treatment of CC-LR mice with TTI-101 resulted in reduced …

Dedifferentiated Liposarcomas Treated With Immune Checkpoint Blockade: The Md Anderson Experience, Madeline B Torres, Cheuk Hong Leung, Marianne Zoghbi, Rossana Lazcano, Davis Ingram, Khalida Wani, Emily Z Keung, M Alejandra Zarzour, Christopher P Scally, Kelly K Hunt, Anthony Conley, Andrew J Bishop, B Ashleigh Guadagnolo, Ahsan Farooqi, Devarati Mitra, Alison K Yoder, Michael S Nakazawa, Dejka Araujo, Andrew Livingston, Ravin Ratan, Shreyaskumar Patel, Vinod Ravi, Alexander J Lazar, Christina L Roland, Neeta Somaiah, Elise F Nassif Haddad

Faculty, Staff and Student Publications

Background: Dedifferentiated liposarcoma (DDLPS) is one of the most common types of soft tissue sarcoma (STS) characterized by liposarcomatous differentiation and a predilection for the retroperitoneum. Despite the growing number of histology-specific immune checkpoint blockade (ICB) trials in STS, it is still difficult to identify the radiographic objective response rate (ORR) for DDLPS in the real world setting. This study aimed to evaluate the ORR and survival of patients with DDLPS treated with ICB at a single center.

Methods: We conducted a retrospective study of 31 patients with pathologically confirmed DDLPS treated with ICB at MD Anderson Cancer Center between …

A Plain Language Summary Of The Final Analysis Of The Griffin Study Of Daratumumab Plus Lenalidomide, Bortezomib, And Dexamethasone For People With Newly Diagnosed Multiple Myeloma, Peter M Voorhees, Douglas W Sborov, Jacob Laubach, Jonathan L Kaufman, Brandi Reeves, Cesar Rodriguez, Rebecca Silbermann, Luciano J Costa, Larry D Anderson, Nitya Nathwani, Nina Shah, Naresh Bumma, Yvonne A Efebera, Sarah A Holstein, Caitlin Costello, Andrzej Jakubowiak, Tanya M Wildes, Robert Z Orlowski, Kenneth H Shain, Andrew J Cowan, Shira Dinner, Katharine S Gries, Huiling Pei, Annelore Cortoos, Sharmila Patel, Thomas S Lin, Saad Z Usmani, Paul G Richardson

Faculty, Staff and Student Publications

No abstract provided.

Grape-Pi: Graph-Based Neural Networks For Enhanced Protein Identification In Proteomics Pipelines, Chunhui Gu, Seyyed Mahmood Ghasemi, Yining Cai, Johannes F Fahrmann, James P Long, Hiroyuki Katayama, Chong Wu, Jody Vykoukal, Jennifer B Dennison, Samir Hanash, Kim-Anh Do, Ehsan Irajizad

Faculty, Staff and Student Publications

Motivation: Protein identification via mass spectrometry (MS) is the primary method for untargeted protein detection. However, the identification process is challenging due to data complexity and the need to control false discovery rates (FDR) of protein identification. To address these challenges, we developed a graph neural network (GNN)-based model, Graph Neural Network using Protein-Protein Interaction for Enhancing Protein Identification (Grape-Pi), which is applicable to all proteomics pipelines. This model leverages protein-protein interaction (PPI) data and employs two types of message-passing layers to integrate evidence from both the target protein and its interactors, thereby improving identification accuracy.

Results: Grape-Pi achieved significant …

Disentangling Effects Of The Dr And Dq Isomers Encoded By The Hla Class Ii Haplotype Drb1*15:01/Dqb1*06:02 To Help Establish The True Risk Allele For Fviii Inhibitor Development In Hemophilia A, Vincent P Diego, Bernadette W Luu, Marcio A Almeida, Raja Rajalingam, Marco Hofmann, Jacob A Galan, Eron G Manusov, Jerry S Powell, Long V Dinh, Henry Mead, Huy Huynh, Anne M Verhagen, Juan M Peralta, Paul V Lehmann, Satish Kumar, Eli J Fine, Joanne E Curran, Harald H Goring, Miguel A Escobar, Sarah Williams-Blangero, Eugene Maraskovsky, John Blangero, Tom E Howard

Faculty, Staff and Student Publications

Introduction: Hemophilia A (HA) patients (HAPs) with the human leukocyte antigen (HLA)-class-II (HLAII) haplotype DRB1*15:01/DQB1*06:02, and thus antigen presenting cells which express HLAII β-polypeptide chains that form heterodimers of DR15- and DQ6-serotypes, respectively, have an increased risk of developing factor (F)VIII inhibitors (FEIs)-neutralizing antibodies against the therapeutic-FVIII-proteins (tFVIIIs) infused to prevent/arrest bleeding. As DRB1*15:01 and DQB1*06:02 exist in strong linkage disequilibrium, association analysis cannot determine which is the actual risk allele.

Methods: To establish the true risk allele of this haplotype, we analyzed the tFVIII-derived peptides (tFVIII-dPs) bound to either the DR or DQ molecules that comprise the individual HLAII …

Inhibition Of Nitric Oxide Synthase Transforms Carotid Occlusion-Mediated Benign Oligemia Into De Novo Large Cerebral Infarction, Ha Kim, Jinyong Chung, Jeong Wook Kang, Dawid Schellingerhout, Soo Ji Lee, Hee Jeong Jang, Inyeong Park, Taesu Kim, Dong-Seok Gwak, Ji Sung Lee, Sung-Ha Hong, Kang-Hoon Je, Hee-Joon Bae, Joohon Sung, Eng H Lo, James Faber, Cenk Ayata, Dong-Eog Kim

Faculty, Staff and Student Publications

No abstract provided.

A Call For Integration Of Trauma-Informed Care Into Occupational Therapy: Improving Provider Competency Through A Case Study Of A Cooking Skills Program For Survivors Of Human Trafficking, Natalie Pravinkumar

OT Doctoral Capstones

Trauma, such as abuse, neglect, and violence, has evident lasting physical and mental health effects, such as chronic illness, behavioral changes, and depression. While trauma-informed care (TIC) helps providers recognize and respond to trauma, this training is often limited to mental health and social work fields. Many survivor populations never receive interventions designed with TIC in mind, restricting outcomes leading to reduced rehabilitation and reintegration.

Occupational therapy (OT) is fundamentally client-centered and functional, making it well suited for TIC. However, while they cover many similar topics, most OT programs do not include specific curriculum on TIC.

TIC education in OT …

Testosterone Plus Lifestyle Therapy Improves Skeletal Muscle Glycolysis In Older Men With Obesity And Hypogonadism, Viola Viola, Marlene Aguilar, Maria Liza Duremdes Nava, Alessandra Celli, Reina Armamento-Villareal, Yoann Barnouin, Nicola Napoli, Nagireeddy Putluri, Clifford Qualls, Dennis T Villareal

Faculty, Staff and Students Publications

Objective: Weight loss in older men with obesity and hypogonadism accelerates musculoskeletal decline, yet the underlying metabolic mechanisms remain unclear. Testosterone replacement therapy (TRT), when added to lifestyle therapy (LT), mitigates this decline, but its metabolic basis has not been defined. We examined skeletal muscle metabolomic adaptations to LT with or without TRT, focusing on glycolysis, the pentose phosphate pathway (PPP), the tricarboxylic acid (TCA) cycle, and carnitine metabolism to identify dominant pathways of metabolic adaptation.

Design: Randomized, double-blind, placebo-controlled trial (LITROS).

Methods: Eighty-three men aged 65 years or older with obesity (BMI ≥30 kg/m2), hypogonadism (testosterone < 10.4 nmol/L), and frailty (Physical Performance Test score ≤31) were randomized to 26 weeks of LT plus TRT (LT+TRT) or LT plus placebo (LT+Pbo). A metabolomic substudy was performed in 44 participants, who underwent serial biopsies of the vastus lateralis for targeted LC-MS/MS analysis of intermediates in glycolysis, PPP, TCA cycle, and carnitine metabolism.

Results: Among the …

Folate Receptor Β Performs An Immune Checkpoint Function In Activated Macrophages, Fenghua Zhang, Md Yusuf Al-Amin, Sagar Utturkar, Rina Jiang, Gregory Cresswell, Rami Alfar, Ian Ophaug-Johansen, Gabriel Bachman, Madduri Srinivasarao, Richard Finnell, Amaya Puig-Kröger, Timothy Ratliff, Philip S Low

Faculty, Staff and Students Publications

Monocytes and macrophages are sentinels of the immune system that distinguish themselves from other cells by expressing the beta isoform of the folate receptor (FRβ). Because FRβ does not bind folate until the monocyte/macrophage is exposed to immunosuppressive cytokines, the question naturally arose whether FRβ might also perform an immune-related function. To examine this matter, we compared the properties of wild type (WT) and FRβ knockout mice. We observe that FRβ knockout (KO) mice display autoimmune symptoms that can include alopecia, enlarged spleens, and dermatitis, despite having normal cellular folate levels. We further demonstrate that syngeneic tumors (TRAMP C2, MC38) …

Small Molecule Screening Identifies Hsp90 As A Modifier Of Rna Foci In Myotonic Dystrophy Type 1, Sara J Johnson, Hannah L Johnson, Reid T Powell, Clifford Stephan, Fabio Stossi, Thomas A Cooper

Faculty, Staff and Students Publications

Myotonic dystrophy type 1 (DM1) is a multisystemic disorder caused by a CTG triplet repeat expansion within the 3' untranslated region of the DMPK gene. Expression of the expanded allele generates RNA containing long tracts of CUG repeats (CUGexp RNA) that form hairpin structures and accumulate in nuclear RNA foci; however, the factors that control DMPK expression and the formation of CUGexp RNA foci remain largely unknown. We performed an unbiased small molecule screen in an immortalized human DM1 skeletal muscle myoblast cell line and identified HSP90 as a modifier of endogenous RNA foci. Small molecule inhibition of HSP90 leads …

Skewed Adaptive Immune Responses Are Involved In Alpha-1 Antitrypsin Deficiency Emphysema, Joselyn Rojas-Quintero, Scott A Ochsner, Hyun-Sung Lee, Christine Cong, Alan Waich Cohen, Adrianne S Colborg, Konstantin Tsoyi, Maria C Basil, Edward Cantu, Ivan O Rosas, Neil J Mckenna, Raúl San-José Estépar, Igor Barjaktarevic, Andrew A Wilson, Francesca Polverino

Faculty, Staff and Students Publications

No abstract provided.

Mice With Lymphatic Dysfunction Develop Pathogenic Lung Tertiary Lymphoid Organs That Model An Autoimmune Emphysema Phenotype Of Copd, Barbara Summers, Kihwan Kim, Anjali Trivedi, Tyler M Lu, Sean Houghton, Jade Palmer-Johnson, Joselyn Rojas-Quintero, Juan Cala-Garcia, Tania Pannellini, Francesca Polverino, Raphaël Lis, Hasina Outtz Reed

Faculty, Staff and Students Publications

We have previously shown that mice with a loss of C-type lectin-like type II (CLEC2), which have lymphatic dysfunction due to the role of CLEC2 in platelets for maintaining separation between the venous and lymphatic system, develop lung tertiary lymphoid organ (TLO) formation and lung injury that resembles an emphysema phenotype of chronic obstructive pulmonary disease (COPD). We now sought to investigate whether and how TLOs in these mice may play a pathogenic role in lung injury that is relevant to human disease. We found that inhibiting TLO formation using an anti-CD20 antibody in CLEC2-deficient mice partially blocked the development …

Advancing Narcolepsy Advocacy: Bridging Patient Narratives And Systemic Change, Ahmed Salem Bahammam, Lindsay Jesteadt, Hamza Dhafar, Amir Sharafkhaneh

Faculty, Staff and Students Publications

We introduce the Stigma-to-Structure Advocacy Framework, a novel, evidence-based model designed to transform narcolepsy advocacy by systematically bridging patient narratives with structural change. Narcolepsy remains a profoundly underdiagnosed and misunderstood neurological disorder, with persistent diagnostic delays and pervasive cultural stigma undermining patient well-being and access to care. Despite recent progress in awareness and support, advocacy efforts remain fragmented and insufficiently integrated with health policy, particularly in low- and middle-income countries. This perspective advances a strategic evolution of narcolepsy advocacy through the Stigma-to-Structure Advocacy Framework, which is anchored in three pillars: narrative-driven awareness, clinical system integration, and policy activation. Drawing on …

Bibliometric And Visualisation Analysis Of Biomass Burning Research In Thailand (1997-2024), Weerachon Sawangproh, Arika Bridhikitti

Applied Environmental Research

Biomass burning is a major driver of air pollution and climate-related impacts in Thailand, but a national-level synthesis of research efforts is lacking. This study conducts a comprehensive bibliometric and qualitative review of 256 peer-reviewed publications from 1997–2024, using Scopus-indexeddata to explore research trends, thematic patterns, and existing gaps. The analysis reveals a strong emphasis on atmospheric chemistry, air quality modeling, and remote sensing, which collectively account for more than 60% of the research landscape.Studies frequently focus on pollutants such as PM2.5,PAHs, carbon monoxide, and heavy metals, with biomass burning identified as a dominant source, especiallyduring the dry season in …

Quantifying Biodiversity In The Absence Of Taxonomic Data: A Study Of Thailand’S Economic Development Zones, Nikorn Mahawan, Wanpen Charoentrakulpeeti

Applied Environmental Research

The biodiversity status measures the ecological capacity of a given area. However, biodiversity assessments in developing countries are limited by the absence of taxonomic data on plants and animals. By developing methods to evaluate biodiversity via alternative data, it is now possible to quantify the ecological carrying capacity in areas where taxonomic data are lacking. The relationship between forest ecosystem health and biodiversity values can be used to estimate biodiversity values by considering the proportions of different land use types that are associated with forest ecosystem abundance. The biodiversity value of the area can be assessed by adding the abundance …

Spatial And Temporal Dynamics Of Water Use Efficiency And Climate Influence In The Central Highlands Of Vietnam Via Satellite Time Series, Thi Nguyen Quang, Hoang Van Hung

Applied Environmental Research

This study investigates the spatial and temporal patterns of water use efficiency (WUE) anomalies across the Central Highlands of Vietnam from 2001–2024 via MODIS time series data, with a focus on seasonal differences and climatic drivers. The results revealed pronounced interannual and spatial variability in the WUE, with significant improvements observed during 2004, 2015, and 2021–2024 and substantial declines during 2005–2008, 2010–2013, and 2016–2017, which coincided with major drought events in the region. Seasonal analysis indicated that WUE was lower during the early dry season and peaked during the postmonsoon months (October–November), reflecting the interplay between water availability and vegetation …

Using A Water Quality Index To Assess The Impacts Of Heavy Metals Contamination For Sustainable Water Management: A Case Study Of The Bang Pakong River, Thailand, Khin Yadana Soe, Pokchat Chutivisut, Wilailuk Niyommaneerat

Applied Environmental Research

Anthropogenic activities such as improper waste disposal, excessive fertilizer use, and industrial effluents cause heavy metal contamination in water, soil, and the atmosphere. Herein, the water quality index (WQI) was used to characterize heavy metal (i.e., cadmium (Cd), arsenic (As), and mercury (Hg)) contamination in the Bang Pakong River, Thailand. Specifically, water samples were collected during the dry season from four stations along the river from 2012–2022. The heavy metal concentrations in the samples were analyzed via atomic absorption spectrophotometry, and WQI values were calculated on the basis of standard water quality parameters. At the four sampling stations, high As …

Halotolerant Biodegradation And Detoxification Of Synthetic Dyes By Marine-Derived Penicillium Oxalicum M6a: Metabolite Profiling And Ecotoxicity Assessment, Ugochukwu Okechukwu Ozojiofor, Mohammed Sani Abdulsalami, Nkechi Eucharia Egbe, Ahmed Ali Haroun, Yakubu Magaji

Applied Environmental Research

The complex aromatic structures of synthetic dyes in contaminated water bodies make them difficult to degrade, posing a serious environmental challenge and representing a significant emerging pollutant that warrants urgent intervention. This study evaluated the biodegradation and detoxification potential of a halotolerant, marine-derived fungal strain, Penicillium oxalicum M6A, isolated from the Nigerian coastline, against Indigo carmine (IC) and Remazol Brilliant Blue R (RBBR). The effects of pH, temperature, salinity, and dye concentration on degradation efficiency, alongside enzymatic activity, were assessed. FTIR and GC‒MS analyses were employed to identify degradation products and predict metabolic pathways, whereas toxicity was evaluated in three …

Blue Carbon Stock Assessment Of The Mangrove Swamp Forest Reserve In Baganga, Davao Oriental, Philippines, Renz Morales Lanaban, Yves Paul M. Montero, Hilario L. Wong, Jr., Marnie Grace I. Sonico

Applied Environmental Research

Mangrove ecosystems are vital carbon sinks, yet they are threatened by anthropogenic pressures and natural disturbances, causing significant carbon stock losses. Given the limited data for Baganga, Davao Oriental, this study quantified the aboveground biomass (AGB) and blue carbon stock in the Lucod mangrove swamp forest reserve. We identified mangrove species, measured AGB and carbon content via allometric equations, and compared storage among species. The results indicated that the mangrove forest AGB was within typical ranges for tropical wet regions and the Asia-Pacific region, but its overall carbon content did not reach highly productive ecosystem levels. Nonparametric analysis revealed significant …

Spatial Distribution And Potential Ecological Risk Of Microplastics In Surface Sediments Of The Inner Gulf Of Thailand, Sarayut Suanluang, Pathompong Vibhatabandhu, Sarawut Srithongouthai

Applied Environmental Research

The global surge in plastic usage during the COVID–19 pandemic raised concerns about increased microplastic (MP) contamination in aquatic environments. This study assessed the abundance, characteristics, and ecological risk of MPs in surface sediments of the inner Gulf of Thailand during the post–COVID–19 period (April 2021). The sediment samples were analyzed via density separation, stereomicroscopic examination, and polymer identification via micro–FTIR. The mean MP abundance was 196.07 ± 85.60 pieces kg-1, with concentrations ranging from 73.08 to 351.19 pieces kg-1. PTFE and PP were the dominant polymer types, comprising 50% and 32% of all the MPs, respectively. Fibers (34%) and …

Health Risk Assessment Of Copper Exposure Through Hand-To-Mouth Activities In The Lithium-Ion Battery Manufacturing Industry, Adisorn Phungkum, Worawat Meevasana, Khanidtha Marungrueang

Applied Environmental Research

This study aims to evaluate the occupational exposure levels of copper (Cu) among workers in a battery manufacturing facility by analyzing the Cu concentrations on hand surfaces at three distinct time periods: before work (BW), before lunch (BL), and after work (AW). A total of 30 workers involved in 13 different workstations or tasks—such as battery cell preparation, spot welding, soldering, and labeling—were included in the study to reflect diverse exposure scenarios. Surface wipe sampling was conducted according to NIOSH Method 9102, and the Cu concentrations were quantified via inductively coupled plasma‒mass spectrometry (ICP‒MS). Additionally, the hazard quotient (HQ) was …

Spatial Estimation Of Trophic State For Reservoir Using Ground Monitoring And Remote Sensing Data, Thong Nguyen Hoang, Van Tran Thi

Applied Environmental Research

Nutrient pollution, also known as eutrophication, is a severe environmental problem that leads to harmful algal blooms in water bodies and affects water supplies for human use. This study aims to determine the trophic state of the reservoir based on the trophic state index (TSI) calculated from ground monitoring data of Secchi depth (SD), total phosphorus (TP), and chlorophyll-a (Chl-a) obtained from 35 points in 2 survey periods during the late rainy season to early dry season 2012–2013 and May 2023. In addition, we combined remote sensing data to spatially estimate the eutrophication situation across the reservoir through correlation analysis …

Efficient Oxidation Of Methylene Blue Via Catalytic Activation Of Peroxymonosulfate Via An Engineered Δ-Feooh/Pili Nutshell Biochar Composite, Lorenz Borromeo

Applied Environmental Research

This study introduces a novel composite catalyst formed by anchoring delta iron oxyhydroxide (δ-FeOOH) onto pyrolyzed Pili nutshell biochar via a room-temperature coprecipitation technique, marking the first application of Pili nutshell waste in advanced oxidation processes for wastewater treatment. This innovative methodology enhances catalyst dispersion and stability, facilitating the activation of peroxymonosulfate (PMS) to generate reactive sulfate radicals (SO4•–) for the degradation of methylene blue (MB), a thiazine dye commonly used in the medical field and the dye industry. Different techniques have been used to characterize synthesized composites in terms of their morphology, elemental composition, surface functional groups, and crystalline …

Assessment Of The Carbon Stock Of Trees In Selected Urban Green Spaces Of Davao City, Philippines, Daiseree Cuabo, Yves P.M. Montero, Daryl S. Salas, John P.M. Viernes

Applied Environmental Research

The combined impacts of deforestation, tree cover loss, and urbanization in urban and suburban areas significantly reduce the capacity of natural carbon sinks to sequester and store carbon. Hence, this study assessed the aboveground biomass (AGB) and carbon stock of trees in the selected green spaces of Davao City. A purposive sampling technique was employed in placing quadrats, with data collected from 27 plots categorized by size. AGB was estimated via an allometric equation, and aboveground carbon (AGC) was derived from the AGB values. A total of 358 individual trees from 25 species, 24 genera, and 13 families were documented. …

Spatial And Temporal Trends In Surface Water Quality And Pollution Sources In Ben Tre, Vietnam: A Principal Component Analysis/Factor Analysis-Based Approach, Nguyen Xuan Tong, Luu Tang Phuc Khang

Applied Environmental Research

Surface water quality is vital for maintaining ecological health and supporting sustainable development, particularly in the Mekong Delta, Vietnam, where water is heavily utilized. However, rapid urbanization and economic activities have led to water pollution. This study assessed the spatial and temporal variations in surface water quality in Ben Tre Province from January 2022 to December 2023 using 384 samples collected across dry and rainy seasons and two zones (headwater streams and cities). The water quality index (WQI) was calculated on the basis of 15 parameters, and principal component analysis/factor analysis was applied to identify pollution sources. Five key factors …

Leveraging Epigenomics And Transcriptomics To Develop High-Dimensional Biomarkers Of Neuroinflammation, Steven C. Pike

Dartmouth College Ph.D Dissertations

Neuroinflammation is a critical physiological phenomenon implicated in most neurological disorders, either as a cause or a consequence of pathology. Our understanding of neuroinflammation is limited by the inability to directly profile the cells of interest. Thus, developing biomarkers of neuroinflammation is clinically urgent as we know neuroinflammation correlates with patient outcomes and treatment success. The recent advances in “omics” technologies, particularly epigenomics and transcriptomics, provides the opportunity for high-dimensional profiling of biospecimens for potential biomarkers. Within this dissertation, I demonstrate that biomarkers obtained from “omics” platforms can detect neuroimmunological phenomena in clinical and preclinical settings. In chapter one, DNA …

It’S Time To Stop Calling People "Stakeholders", Bethann Garramon Merkle, Evelyn Valdez-Ward, Priya Shukla, Skylar R. Bayer

Human–Wildlife Interactions

Although the term “stakeholder” has been widely used in science communication, recent expansion in the discourse around the negative connotations of the term necessitate that scientists and practitioners cease using the term. We discuss why this shift is necessary, how it affects our own praxis, and suggest resources for working through more respectful and just language. Looking to the science communication literature can help recalibrate terminology in positive ways.

Evaluating Lethal Coyote Management In The Chicago Metropolitan Area Using A Conflict Recurrence Metric, Jeffrey T. Schultz, Scott Beckerman, Robert Erickson, Danielle Montgomery, Stewart W. Breck

Human–Wildlife Interactions

Human–coyote (Canis latrans) conflict in urban environments is prevalent in cities throughout the United States. Urban areas commonly use nonlethal techniques to mitigate coyote-caused conflicts but will also incorporate selective removal of individual coyotes when conflicts persist. However, little research has evaluated these management strategies. This study analyzed coyote removal efforts conducted in the Chicago Metropolitan Area from 2010 to 2020. To evaluate the management actions, we used “time without incidence”—the time elapsing from an initial conflict until either a subsequent conflict occurred in the same area, or when the data collection period ended—as an index of effectiveness. …

Monograph Available: Urban Coyotes As A Source Of Conflict With Humans: An Evaluation Of Common Management Practices

Human–Wildlife Interactions

This is an announcement about the published monograph titled "Urban Coyotes as a Source of Conflict with Humans: An Evaluation of Common Management Practices." This publication, part of the HWI Monograph Series, is online and open access.

Relative Seat Height Effects On Knee Joint Kinematics In Older Adults, Sadie N. Zimmerman

Research Papers

No abstract provided.