Digital Commons Network^™

Burden Of Seasonal Human Coronavirus Infections In Hematopoietic Cell Transplant Recipients, Fareed Khawaja, Terri Lynn Shigle, Layale Yaghi, May Daher, Jeremy L Ramdial, Ella Ariza-Heredia, Ying Jiang, Roy F Chemaly

Faculty, Staff and Student Publications

Background: Community respiratory viruses, such as seasonal human coronavirus (HCoV), commonly infect hematopoietic cell transplant (HCT) recipients. Recognizing the risk factors and outcomes of HCoV infections in HCT recipients is essential for the future development of potentially lifesaving therapeutics.

Methods: We performed a retrospective review of all HCoV-infected HCT recipients from September 1, 2015 to August 31, 2017, at our institution. Patients were classified with upper respiratory tract infection (URI) or lower respiratory infection (LRI) based on predefined definitions for respiratory viral infections in HCT recipients. Patient data were collected to identify risk factors for HCoV LRI, and to calculate …

Partial Agonism In Heteromeric Gluk2/Gluk5 Kainate Receptor, Nabina Paudyal, Anindita Das, Elisa Carrillo, Vladimir Berka, Vasanthi Jayaraman

Faculty, Staff and Student Publications

Kainate receptors are a subtype of ionotropic glutamate receptors that form transmembrane channels upon binding glutamate. Here, we have investigated the mechanism of partial agonism in heteromeric GluK2/K5 receptors, where the GluK2 and GluK5 subunits have distinct agonist binding profiles. Using single-molecule Förster resonance energy transfer, we found that at the bi-lobed agonist-binding domain, the partial agonist AMPA-bound receptor occupied intermediate cleft closure conformational states at the GluK2 cleft, compared to the more open cleft conformations in apo form and more closed cleft conformations in the full agonist glutamate-bound form. In contrast, there is no significant difference in cleft closure …

Tnik-Driven Regulation Of Erk5 Transcriptional Activity In Endothelial Cells, Venkata Subrahmanya Kumar Samanthapudi, Sivareddy Kotla, Nhat-Tu Le

Faculty, Staff and Student Publications

Extracellular signal-regulated kinase 5 (ERK5) is essential for cardiovascular development and endothelial cell (EC) function. Activation of ERK5 through MEK5-mediated phosphorylation at threonine 218 and tyrosine 220 (T218/Y220) drives the transcriptional activation of myocyte enhancer factor-2 (MEF2), promoting the expression of KLF2 and KLF4—key transcription factors that maintain vascular homeostasis. We previously demonstrated that ponatinib suppresses ERK5 transcriptional activity without affecting laminar-flow (l-flow)-induced T218/Y220 phosphorylation, suggesting a non-canonical regulatory mechanism. Since ponatinib inhibits Traf2- and Nck-interacting kinase (TNIK), we hypothesized that TNIK modulates ERK5 transcriptional activity. Using a mammalian one-hybrid assay and quantitative RT-PCR (qRT-PCR), we show that TNIK …

Dissolved Organic Carbon In Coastal Waters: Global Patterns, Stocks And Environmental Physical Controls, Christian Lønborg, Isabel Fuentes-Santos, Cátia Carreira, Valentina Amaral, Javier Arístegui, Punyasloke Bhadury, Mariana Bernardi Bif, Maria Ll. Calleja, Qi Chen, Luiz C. Cotovicz, Stefano Cozzi, Bradley D. Eyre, E. Elena García-Martín, Michele Giani, Rafael Gonçalves-Araujo, Renee Gruber, Dennis A. Hansell, Johnna M. Holding, William Hunter, J. Severino Ibánhez, Valeria Ibello, Piotr Kowalczuk, Federica Maggioni, Paolo Magni, Patrick Martin, S. Leigh Mccallister, Xosé Anxelu Morán, Joanne M. Oakes, Helena Osterholz, Hyekyung Park, Digna Rueda-Roa, Jiang Shan, Eva Teira, Nicholas Ward, Youhei Yamashita, Liyang Yang, Qiang Zheng, Xosé Antón Álvarez-Salgado

Marine Science Faculty Publications

Dissolved organic carbon (DOC) in coastal waters is integral to biogeochemical cycling, but global and regional drivers of DOC are still uncertain. In this study we explored spatial and temporal differences in DOC concentrations and stocks across the global coastal ocean, and how these relate to temperature and salinity. We estimated a global median coastal DOC stock of 3.15 Pg C (interquartile range (IQR) = 0.85 Pg C), with median DOC concentrations being 2.2 times higher than in open ocean surface waters. Globally and seasonally, salinity was the main driver of DOC with concentrations correlated negatively with salinity, without a …

How Can Tailored Entrepreneurship Training Effectively Support The Emancipation Of People With Disabilities In Ireland?, Ahsan Habib

Doctoral

This thesis investigates the impact of tailored entrepreneurship training on the perceived emancipation of aspiring entrepreneurs with disabilities in Ireland. This community is significantly underrepresented in the labour market, yet it is hindered in accessing self-employment opportunities due to a lack of specific training and limited access to necessary resources. Furthermore, there is a dearth of knowledge in academic literature addressing the influence of tailored entrepreneurship programmes targeted at people with disabilities. To address this knowledge gap, this study gathered data from in-depth interviews with 21 key informants (including nine participants from TU Dublin’s entrepreneurship training programme, five representatives from …

Anti-Cd137 Agonist Antibody-Independent And Clinically Feasible Preparation Of Tumor-Infiltrating Lymphocytes From Soft Tissue Sarcoma And Osteosarcoma, Yining Jin, Zhiliang Jia, Xueqing Xia, Nancy B Gordon, Joseph A Ludwig, Neeta Somaiah, Shulin Li

Faculty, Staff and Student Publications

Background: Tumor infiltrating lymphocytes (TILs) therapy has been proved for treatment of metastatic melanoma and is under investigation for other types of solid tumors. However, these successes are threatened by discontinued supply of GMP-grade anti-CD137 agonist, a key TIL preparation reagent. Therefore, exploring a GMP-adherent method for expanding endogenous TILs without anti-CD137 agonist is urgent. Toward this end, we aimed to establish an anti-CD137-independent and clinically feasible TIL expansion protocol to prepare TILs from under investigated sarcoma tumors.

Methods: We collected resected tumors from patients and cut tissues into fragments. We used IL-2 and T-cell activator CD3/CD28 without anti-CD137 agonist …

Intrapartum Glycemic Control And Clinical Outcomes, Ghamar Bitar, Michal Fishel Bartal

Faculty, Staff and Student Publications

Current recommendations encourage strict intrapartum glycemic control for individuals with diabetes in pregnancy to optimize maternal and neonatal outcomes. However, established evidence is limited in providing a strong association between strict maternal blood glucose control and neonatal outcomes.

Using Content Validity Index Methodology For Cross-Cultural Translation Of A Patient-Reported Outcome Measure For Head And Neck Cancer, Janet H Van Cleave, Alizendie Guerra, Eva Liang, Carolina Gutiérrez, Ron J Karni, Marcely Tsikis, Geanise Pearl C Nguyen, Allison P Squires

Faculty, Staff and Student Publications

Introduction: Translations of patient-reported measures may not account for structural and cultural differences in shared languages spoken in multiple countries, such as English, Spanish, Arabic, or Russian. The objective of this research was to create a cross-cultural Spanish translation of the New York University (NYU) Electronic Patient Visit Assessment (ePVA)© for head and neck cancer (HNC), a patient-reported symptom measure available only in English.

Methods: Using the Content Validity Index (CVI) methodology, an expert panel of nurses (n = 6) proficient in Spanish and English independently reviewed and rated a forward translation of the ePVA, a measure consisting of …

Effect Of Family-Centered Care Interventions On Motor And Neurobehavior Development Of Very Preterm Infants: A Systematic Review And Meta-Analysis, Manasa Kolibylu Raghupathy, Shradha S. Parsekar, Shubha R. Nayak, Kalesh M. Karun, Sonia Khurana, Alicia J. Spittle, Leslie Edward S. Lewis, Bhamini Krishna Rao

Rehabilitation Sciences Faculty Publications

Aim

To assess the effectiveness of family-centered care (FCC) interventions on motor and neurobehavior development of very preterm infants.

Method

Randomized and quasi-randomized trials assessing the effect of FCC on motor and neurobehavioral outcomes in very preterm infants (28–32 wk gestation) were included. Five electronic databases and grey literature were searched from January 2010 to August 2022. Two reviewers independently screened the titles/abstracts and full texts, assessed the risk of bias, and extracted data. The Cochrane Risk of Bias 2.0 Tool and GRADE were used for risk and evidence certainty assessments. Meta-analysis or narrative synthesis was performed based on data …

Optimizing Ethephon Application Timing For ‘Meyer’ Zoysiagrass Seedhead Suppression, Brandon C. Mcnally

Horticulture Faculty Publications and Presentations

Zoysiagrass (Zoysia spp. Willd.) is a desirable, low-input turfgrass species used on golf courses. However, prolific zoysiagrass seedhead production in the spring can increase golf course maintenance costs and reduce aesthetics. Previous research demonstrates that a single autumn ethephon application can suppress zoysiagrass seedhead production the following spring, but the optimum application timing is not well-defined. The objective of this research was to determine the optimum window for an effective ethephon application for ‘Meyer’ zoysiagrass seedhead suppression. Small-plot field research was conducted in Indiana, Kansas, Arkansas, and Tennessee. Seedheads were suppressed up to 99% depending on application timing. In …

Correspondence To Editorial 2 On "Genomic Biomarkers To Predict Response To Atezolizumab Plus Bevacizumab Immunotherapy In Hepatocellular Carcinoma: Insights From The Imbrave150 Trial", Sun Young Yim, Sung Hwan Lee, Ji Hoon Kim, Sunyoung S Lee, Ahmed O Kaseb, Ju-Seog Lee

Faculty, Staff and Student Publications

No abstract provided.

Characterization Of Adaptive Quorum Sensing In Pseudomonas Aeruginosa, Kayla Simanek

Electronic Theses & Dissertations (2024 - present)

Pseudomonas aeruginosa is an opportunistic pathogen that is highly antibiotic resistant and causes tens of thousands of infections each year. It persists in hospitals by forming biofilms on medical equipment like ventilators and catheters, making it difficult to eradicate. Biofilm formation, among other virulence factors of P. aeruginosa, is regulated through quorum sensing, a mechanism of bacterial communication. Quorum sensing is primarily coordinated through LuxI-R type systems comprised of an autoinducer synthase and receptor, respectively. Canonically, the first system to be expressed is LasI-R, and LasR upregulates the second arm of the quorum sensing network, the RhlI-R system. Research …

A Phase Ib/Ii Trial Of Neoadjuvant Neratinib Added To Standard Therapy In Patients With Her2-Positive Or Hr-Positive/Her2-Negative Inflammatory Breast Cancer (Including Stage Iii And Iv Disease), Bora Lim, Angela Marx, Megumi Kai, Angela Alexander, Roland Bassett, Wencai Ma, Jie Willey, Huiming Sun, Azadeh Nasrazadani, Mohammad M Mohammad, Jianhua Zhang, Anthony Lucci, Susie X Sun, Michael C Stauder, Gary J Whitman, Huong Le-Petross, Vicente Valero, Wendy A Woodward, Rachel M Layman

Faculty, Staff and Student Publications

Background: Inflammatory breast cancer (IBC) is rare but aggressive, characterized by the rapid onset of diffuse skin erythema, edema, tenderness, induration, and fast metastasis. Both hormone receptor positive (HR+) and human epidermal receptor 2 positive (HER2+) are associated with inferior response after neoadjuvant systemic therapy (NAST) compared to non-IBC. Despite multimodal treatment approaches, the 3-year overall survival rate for stage III IBC remains low at approximately 74%, around 10% lower than the 83% for non-IBC.

Objectives: To evaluate whether the addition of neratinib, an irreversible pan-ErbB receptor small molecule tyrosine kinase inhibitor, improves the rate of pathological complete response in …

Combining Biology-Based And Mri Data-Driven Modeling To Predict Response To Neoadjuvant Chemotherapy In Patients With Triple-Negative Breast Cancer, Casey E Stowers, Chengyue Wu, Zhan Xu, Sidharth Kumar, Clinton Yam, Jong Bum Son, Jingfei Ma, Jonathan I Tamir, Gaiane M Rauch, Thomas E Yankeelov

Faculty, Staff and Student Publications

Triple-negative breast cancer (TNBC) is an aggressive breast cancer subtype associated with limited targeted treatment options, heterogeneous treatment response, and high risk of early recurrence. Artificial intelligence (AI) has rapidly emerged as a powerful tool to address key clinical challenges in TNBC across diagnosis, treatment response assessment, and prognosis. Diagnostic and staging challenges persist due to variable imaging features in TNBC and limitations in conventional modalities, increasing the risk of delayed detection. Predicting response to neoadjuvant systemic therapy remains difficult, as patient responses are heterogeneous, and existing clinical markers provide limited early predictive value. Prognostication in TNBC is similarly constrained …

How Do Young Adults With Drug Use Disorder (Dud) Utilize Treatment? Exploring And Examining Lived Experiences Towards Treatment Completion In Indonesia, Dewi Kartikawatiningsih

Electronic Theses & Dissertations (2024 - present)

In Indonesia which has the highest rate of drug addiction in Southeast Asia, there is currently little knowledge about how young adults perceive the barriers faced when completing treatment or how treatment providers' perspectives influence their treatment completion. Understanding and identifying barriers to treatment completion is essential to making drug treatment more effective. The purpose of this study is to explore the perspectives and live experiences of young adults with DUD and their addiction counselors to develop a deeper understanding of treatment needs. This study interviewed 33 clients and 15 counselors from the rehabilitation center of the Badan Nasional Narkotika …

Scope And Mechanism Of The Ruthenium-Catalyzed Sp3 C–H Coupling Reaction Of 2-Alkylindoles With Enones For The Synthesis Of Carbazole Derivatives, Krishna Prasad Gnyawali, Mina Son, Donghun Hwang, Nuwan Asanka Pannilawithana, Mu-Hyun Baik, Chase S. Yi

Chemistry Faculty Research and Publications

The catalytic system consisting of a cationic Ru–H complex 1 and 3,4,5,6-tetrachloro-1,2-benzoquinone (L1) was found to be highly effective for the dehydrative sp³ C–H coupling reaction of 2-alkyl substituted indoles with enones to form 2,4-disubstituted carbazole products. The analogous coupling reaction of 2-alkylindoles with linear enones bearing the cyclic olefinic group afforded tetracyclic carbazole products. A normal deuterium kinetic isotope effect was measured from the coupling reaction of 1,2-dimethylindole versus 1-methyl-2-(methyl-d₃)indole with (E)-3-penten-2-one (k_H/k_D = 2.5). The Hammett plot was constructed from the reaction of para-substituted …

Isotonic Phase I Cancer Clinical Trial Design Utilizing Patient-Reported Outcomes, Nolan A Wages, Ruitao Lin

Faculty, Staff and Student Publications

This article considers the concept of designing Phase I clinical trials using both clinician- and patient-reported outcomes to adaptively allocate study participants to tolerable doses and determine the maximum tolerated dose (MTD) at the study conclusion. We describe a new isotonic patient-reported outcome (PRO-ISO) Phase I design with the flexibility of allocating patients to lower, more tolerable regimens if a large number of PRO-DLT events are seen at higher doses. We conduct simulation studies of the operating characteristics of the design and compared them to the patient-reported outcomes continual reassessment method (PRO-CRM). We illustrate that the PRO-ISO makes appropriate dose …

Bismuth-Infused Perivascular Wrap Facilitates Delivery Of Mesenchymal Stem Cells And Attenuation Of Neointimal Hyperplasia In Rat Arteriovenous Fistulas, Allan John R Barcena, Joy Vanessa D Perez, Marvin R Bernardino, Jossana A Damasco, Erin Marie D San Valentin, Carleigh Klusman, Benjamin Martin, Gino Martin Canlas, Francisco M Heralde, Natalie Fowlkes, Richard R Bouchard, Jizhong Cheng, Steven Y Huang, Marites P Melancon

Faculty, Staff and Student Publications

BACKGROUND: Mesenchymal stem cells (MSCs) have emerged as novel therapies for supporting arteriovenous fistula (AVF) maturation, and bioresorbable polymeric scaffolds have enabled sustained MSC delivery into maturing AVFs. However, the radiolucency of biopolymeric wraps prevents in vivo monitoring of their integrity and location, hindering long-term preclinical investigations.

METHODS: We infused bismuth nanoparticles (BiNPs) into polycaprolactone (PCL) to fabricate an electrospun perivascular wrap capable of MSC delivery and conducive to longitudinal monitoring using conventional imaging. We tested the wraps' effects on the attenuation of markers of neointimal hyperplasia (i.e., endothelial dysfunction, hypoxia, and inflammation), the leading cause of AVF failure, in …

Editorial: Women In Antimicrobials, Resistance And Chemotherapy: 2023, Cindy Shuan Ju Teh, Krassimira R. Hristova, Ana R. Freitas

Biological Sciences Faculty Research and Publications

No abstract provided.

Organ Of Corti Macrophages: A Distinct Group Of Cochlear Macrophages With Potential Roles In Supporting Cell Degeneration And Survival, Mengxiao Ye, Celia Zhang, Dalian Ding, Guang-Di Chen, Henry J Adler, Rania Sharaf, Bo Hua Hu

Faculty, Staff and Student Publications

Macrophages are the primary immune cells in the cochlea, essential for maintaining cochlear homeostasis and orchestrating inflammatory responses to pathological events. Although these cells have been found in various parts of the cochlea, their presence in the organ of Corti, a critical structure for acoustic sensing, remains poorly understood. The present study was designed to examine macrophage responses to ototoxic drug-induced cochlear damage and age-related cochlear degeneration, with a particular focus on the pathological conditions that trigger macrophage recruitment into the organ of Corti. We used a model of ototoxicity induced by cyclodextrin, a cyclic oligosaccharide known for its ability …

Integrating Multi-Omics Data To Uncover Prostate Tissue Dna Methylation Biomarkers And Target Genes For Prostate Cancer Risk, Shuai Liu, Jingjing Zhu, Dylan Green, Hua Zhong, Quan Long, Chong Wu, Liang Wang, Youping Deng, Lang Wu

Faculty, Staff and Student Publications

Previous studies have indicated that specific CpG sites may be linked to the risk of prostate cancer (PCa) by regulating the expression of PCa target genes. However, most existing studies aim to identify DNA methylation (DNAm) biomarkers through blood tissue genetic instruments, which impedes the identification of relevant biomarkers in prostate tissue. To identify PCa risk-associated CpG sites in prostate tissue, we established genetic prediction models of DNAm levels using data from normal prostate samples in the GTEx (N = 108) and assessed associations between genetically predicted DNAm in prostate and PCa risk by studying 122,188 cases and 604,640 controls. …

Three-Dimensional Deep Learning Normal Tissue Complication Probability Model To Predict Late Xerostomia In Patients With Head And Neck Cancer, Hung Chu, Suzanne P M De Vette, Hendrike Neh, Nanna M Sijtsema, Roel J H M Steenbakkers, Amy Moreno, Johannes A Langendijk, Peter M A Van Ooijen, Clifton D Fuller, Lisanne V Van Dijk

Faculty, Staff and Student Publications

Purpose: Conventional normal tissue complication probability (NTCP) models for patients with head and neck cancer are typically based on single-value variables, which, for radiation-induced xerostomia, are baseline xerostomia and mean salivary gland doses. This study aimed to improve the prediction of late xerostomia by using 3-dimensional information from radiation dose distributions, computed tomography imaging, organ-at-risk segmentations, and clinical variables with deep learning (DL).

Methods and materials: An international cohort of 1208 patients with head and neck cancer from 2 institutes was used to train and twice validate DL models (deep convolutional neural network, EfficientNet-v2, and ResNet) with 3-dimensional dose distribution, …

Deep Dive Into Targeted Therapies: Understanding Idh1-Mutant Aml Treatments [Podcast], Amer M Zeidan, Courtney Dinardo

Faculty, Staff and Student Publications

This podcast episode reviews recent advances in the treatment of IDH1-mutant acute myeloid leukemia (AML), focusing on the mechanisms, efficacy, and safety profiles of approved IDH1 inhibitors. The purpose is to present expert insights and clinical data from key trials that underscore the clinical benefits of these targeted therapies. Through discussion of key findings from pivotal clinical trial studies, including data supporting the use of these agents in both newly diagnosed and relapsed or refractory (R/R) settings, the episode highlights significant outcomes such as increased overall response and prolonged duration of remission in patients treated with IDH1 inhibitors. The analysis …

In-Person Versus Peer-Coordinated Virtual Health Coaching For Metabolic And Behavioral Outcomes In Women In Sober Living Facilities, Craig R. Witt

Dissertations

Background: Women in early recovery from substance use disorder often face metabolic health vulnerabilities, yet physical health behaviors are frequently under-emphasized in sober living settings. Feasible and accessible wellness strategies are needed to support both behavioral and metabolic health in this population.

Purpose: To compare the effects of professionally delivered in-person health coaching versus peer-coordinated virtual health coaching on metabolic outcomes and health-promoting behaviors among women in sober living facilities.

Methods: In this quasi-experimental study, 32 women enrolled in a 12-week group-based health coaching program focused on nutrition, physical activity, and stress management; 18 completed post-intervention assessments (in-person: n = …

Editorial: To Know Or Not To Know: Causes And Evolution Of Lack Of Awareness Of Cognitive Decline In Neurodegenerative Diseases, Volume Ii, Federica Cacciamani, Kristy A. Nielson, Bernard J. Hanseeuw, Geoffroy P. Gagliardi, Patrizia Vannini

Psychology Faculty Research and Publications

Anosognosia, or the lack of awareness of cognitive, behavioral, or functional deficits, represents a critical challenge in the clinical management of neurodegenerative diseases such as Alzheimer's disease (AD) and frontotemporal dementia. This condition not only impacts patients, caregivers, and healthcare systems (D'Souza et al., 2011; Turró-Garriga et al., 2013) but also raises important questions about its underlying mechanisms and evolution (Hanseeuw et al., 2020; Starkstein, 2014; Vannini et al., 2017). Despite its critical importance, significant gaps remain in our understanding of cognitive self-awareness in neurodegenerative diseases. Building on the momentum of the first edition of To Know or Not to …

Latent Subtypes Of Comorbidities In Multiple Sclerosis Patients: Insights From Social Media, Laxmi Manasa Gorugantu, Nevine Nawar, Omar F. El-Gayar

Research & Publications

Multiple Sclerosis is a chronic neurological disease associated with various physical and cognitive impairments. Individuals with MS might also experience medical and psychiatric comorbidities that can exacerbate the severity of the disease and lower their overall well-being. Therefore, it becomes essential to identify these co-occurring health conditions at the early stages to optimize treatment and improve patient outcomes. Consequently, the objective of this study is to explore the commonly occurring comorbidities among MS patients around the globe from social media discourse. Furthermore, it aims to unveil public perceptions, providing insights that might not be captured via clinical research methods. The …

Germination Capacity Of Artemisia Umbelliformis Lam. Wild Populations And Agro-Techniques To Enhance Seedling Production, Matteo Case, Eric Mozzanini, Andrea Mainett, Íris Marisa Maxaieie Victorino, Erica Lumini, Sonia Demasi, Valeria Bianciotto, Laura Poggio, Valentina Scariot

All Grantees Publications

Artemisia umbelliformis Lam. is an alpine herbaceous species that grows in the wild and is mainly used for producing génépi liqueur. It has applications as an ingredient in several food products. Its propagation and cultivation have become the only way to ensure a sustainable supply, thus conserving its occurrence in natural habitats. However, low success rates in seed germination usually limit its propagation. Selected seeds and fine-tuned agro-techniques are priorities in nursery production systems. The current research explored seed germination in three wild A. umbelliformis populations from Valnontey, Soana, and Urtier in the Italian Alps. We evaluated seed germination ability …

Biobased Emulsion Breakers: Investigating Red Onion Skin And Orange Mesocarp Extracts For Oilfield Application, Victor-Oji Cynthia Onyekachi, Emechebe, Stanley Chijioke, Ikwani Chizurumoke God’Sdelight, Opusunju Allwell, Akaranta Onyewuchi

All Grantees Publications

Oilfield emulsions pose significant operational challenges, affecting crude oil recovery efficiency and refining processes. Conventional chemical demulsifiers, often derived from petroleum-based compounds, pose environmental and economic concerns due to their toxicity and high production costs. This study investigates the potential of plant-based alternatives—Red Onion Skin Extract (ROSE) and Orange Mesocarp Extract (OME) - as environmentally friendly, cost-effective demulsifiers. This novel approach leverages the bioactive compounds in these extracts to destabilize oil-water emulsions efficiently. Four demulsifier formulations were developed: ROSE, OME, ROSE-NaBenzoate (ROSE-NaB), and OME-NaBenzoate (OME-NaB). Fourier Transform Infrared (FTIR) spectroscopy confirmed the presence of active functional groups responsible for interfacial …

Geagrow: A Mobile Tool For Soil Nutrient Prediction And Fertilizer Optimization Using Artificial Neural Networks, Olusegun Folorunso, Oluwafolake Ojo, Mutiu Busari, Muftau Adebayo, Joshua Adejumobi, Daniel Folorunso, Femi Ayo, Orobosade Alabi, Olusola Olabanjo

All Grantees Publications

Introduction: Most farmers in Nigeria lack knowledge of their farmland’s nutrient content, often relying on intuition for crop cultivation. Even when aware, they struggle to interpret soil information, leading to improper fertilizer application, which can degrade soil and ground water quality. Traditional soil nutrient analysis requires field sample collection and laboratory analysis; a tedious and timeconsuming process. Digital Soil Mapping (DSM) leverages Machine Learning (ML) to create detailed soil maps, helping mitigate nutrient depletion. Despite its growing use, existing DSM-based ML methods face challenges in prediction accuracy and data representation. Aim: This study presents GeaGrow, an innovative mobile app that …

Therapeutic Potential Of Brassica Carinata Microgreens Extract In Alleviating Symptoms Of Type 2 Diabetes In Wistar Rats, Lilian Nakakaawa, Ifeoluwa D. Gbala, Joel L. Bargul, Xavier Cheseto, John M. Wesonga

All Peer-Reviewed Publications

Microgreens of Brassica plants have attracted increasing research interest in the management of the prevailing epidemic of Type 2 diabetes mellitus (T2DM) because of their high nutritional value. This study evaluated the antidiabetic effects of Brassica carinata Microgreens Ethanolic Extract (BMEE) in type-2 diabetic rats. For the normoglycemic assay, rats were divided into five groups and received a single oral dose of 100, 250, and 500 mg/kg of BMEE while the control groups received distilled water and Glibenclamide. Fasting blood glucose (FBG) levels were determined on a weekly basis for 28 days in diabetic rats after treatment with BMEE at …