Investigating The Effect Of Artificial Sweeteners On Fitness And Metastasis In Drosophila Melanogaster, Om R. Patel

Honors Undergraduate Theses

Artificial sweeteners are widely used sugar substitutes, yet their potential effects on health remain poorly understood. For example, more evidence suggests that frequent consumers of sugar substitutes may also be at increased risk of excessive weight gain, metabolic syndrome, and type 2 diabetes, which contradicts the original purpose of artificial sweeteners. This thesis investigates the impact of artificial sweeteners on health using Drosophila melanogaster as a model organism, focusing on three key areas: viability, excretion, and cancer metastasis. Viability assays revealed that flies exposed to artificial sweeteners exhibited a decrease in progeny, with some concentrations increasing progeny but most decreasing …

Post-Translational Modification Of The Low-Density Lipoprotein Receptor By Serine Proteases, Matthew E. Ruiz

Honors Undergraduate Theses

Hypercholesterolemia is a disease affecting many Americans and adults worldwide and can lead to further complications such as atherosclerosis, stroke, or pulmonary embolisms making it a major risk factor for heart disease. The disease states are caused by chronically elevated levels of VLDLs that get broken down into LDLs. Cells expressing the LDLR can endocytose LDLs from the blood for use intracellularly as cholesterol and prevent plasma cholesterol deposition in the endothelium. Current treatments include leading healthier lifestyles through dieting and exercise, or pharmacological treatments targeting cellular cholesterol production or dietary cholesterol uptake from the GI tract. The SREBPs are …

The Effects Of Probiotics As A Complementary Treatment In Recurrent Bacterial Vaginosis And Vulvovaginal Candidiasis In Women: A Systematic Review, Luisana Rodriguez

Honors Undergraduate Theses

Vaginal infections such as Bacterial Vaginosis (BV) and Vulvovaginal Candidiasis (VVC) affect women globally, causing not only significant uncomfortable physical symptoms, psychological distress, and economic burden but also health complications that can have important repercussions later. Despite the standard treatment of using antifungals or antibiotics, recurrency is a prominent issue, which brings using probiotics as a complementary therapy to restore the vaginal microbiome and prevent another episode. This systematic review evaluates the efficacy of probiotics as a complementary treatment to reduce the recurrence rates of BV and VVC, as primary adjuncts to conventional therapies, or as a standalone option.

A …

Threading The Needle: Chinese American Adoptees And The In-Between, Annalee Johnson

Honors Undergraduate Theses

Threading the Needle is a short documentary that investigates the relationships between Chinese American adoptees, their families, and their heritage. The film features two primary participants, Mia Nails and Annalee “AJ” Johnson as they reflect on their Asian American identity, experiences with racism, and their struggles with cultural estrangement. The similarities and differences in their perspectives shed light on both the wonderful and the heartbreaking circumstances of adoption. The contemporary value of the film lies in how it challenges popular representations of the Asian American experience: Though in recent years, Asian American media has become more present in popular culture, …

Mental Illness Identity And Social Media Use In Generation Z, Tobey Smith

Honors Undergraduate Theses

The present study investigated factors that predict a high degree of mental illness identity among Generation Z college students. Specifically, the author aimed to evaluate social media use and other psychosocial factors, including social isolation, self-esteem, well-being, discrimination, and attitude toward recovery. Two-hundred and seventeen participants were recruited using SONA and social media. Participants completed scales to measure the variables of interest: Illness Identity Questionnaire - Mental Health, Rosenberg Self-Esteem Scale, Warwick-Edinburgh Mental Well-being Scale, Hope and Coping in Recovery Scale, Cornwell Perceived Isolation Scale, Stigma Scale, Social Media Use Scale, and a set of demographic questions. Pearson bivariate correlations, …

Improving Safe And Effective Management Of Pain At Home, Alayna V. Olivarez

Honors Undergraduate Theses

Pain is the most common clinical symptom in individuals with a cancer diagnosis. Additionally, home is the preferred place for cancer care which introduces numerous challenges for cancer pain management. The primary purpose of this literature review is to identify support interventions to enhance pain control, prevent exacerbations in pain, and optimize quality of life in individuals with cancer transitioning from the acute care setting to home. The secondary purpose of this review is to analyze patient-specific barriers influencing self-efficacy of pain management and overall health outcomes in the target population. A systematic literature search was conducted using CINAHL, EBSCOhost, …

Navigating Online Dating: Exploring The Intersection Of Attachment Styles, Parental Attachments, And Sociosexuality In Online Dating Among College Students, Jensley Velez-Lozada

Honors Undergraduate Theses

The aim of this thesis is to explore the connection between attachment styles, parental attachment, and sociosexuality as predictors of online dating attitudes among college students. As society navigates this new digital era of online dating, how does it continue to transform young adults as they form romantic and sexual connections? It becomes increasingly important to understand the psychological mechanisms that influence these behaviors. This study examined how anxious and avoidant attachment styles, parental attachment, and sociosexuality may have contributed to online hookup attempts and outcomes behaviors. It also examined how these variables interacted and influenced both the likelihood of …

The Effects Of Demographic Variables On Covid-19 Attitudes Surrounding The 2020 Election, Shelby K. Dalbec

Honors Undergraduate Theses

The COVID-19 pandemic was a worldwide phenomenon, with far-reaching consequences in all sectors of society, including the 2020 election. To better understand the implications of this global occurrence, this research examines the extent to which demographic variables influenced public opinions surrounding the COVID-19 pandemic. This study takes a quantitative approach, analyzing datasets from the 2020 American National Elections Studies (ANES). It examines demographic, socioeconomic, and political factors as independent variables, with dependent variables that capture attitudes related to the COVID-19 pandemic. I hypothesized that there would be a strong relationship between party identification and COVID-19 attitudes. This study found that …

How Does The Modern Supreme Court Treat The Idea Of Retribution In The Context Of Capital Punishment?, Paige Forsberg

Honors Undergraduate Theses

This thesis explores the modern U.S. Supreme Court's treatment of retribution in the context of capital punishment, analyzing how justices have framed and justified the death penalty as a form of justice. Through the examination of key Supreme Court rulings and legal arguments, this study evaluates the evolving role of retribution in the Court’s decisions on death penalty cases, highlighting how judicial reasoning has shifted over time in response to legal, philosophical, and societal developments.

Retribution, long considered one of the primary justifications for capital punishment, is examined through a nuanced lens in this study. While historically viewed as a …

Elucidation Of The Post-Transcriptional Regulation And Role In Iron Homeostasis Of The Outer Membrane Vesicle Protein Ynce In Salmonella, Mira J. Schmidt

Honors Undergraduate Theses

Iron is an essential element for most bacteria as it is a crucial cofactor for enzymes involved in fundamental reactions such as DNA synthesis. Despite being the fourth most abundant element on Earth, bacteria face challenges acquiring iron under aerobic conditions due to the poor solubility of its oxidized form (Fe³⁺). To overcome this, bacteria have developed various strategies of iron acquisition, such as the production of siderophores. Siderophores are small molecules that scavenge free Fe³⁺ in iron-deprived environments. Iron acquisition is tightly regulated due to its capability of promoting hydrogen peroxide formation via the Fenton reaction. In Salmonella Typhimurium, …

The Effects Of School-Based Menstruation Education Programs On Anxiety And Self-Efficacy In Adolescent Girls: A Systematic Review, Hannah C. Hart

Honors Undergraduate Theses

A significant global knowledge gap exists for adolescent girls regarding what constitutes a healthy menstrual cycle, proper menstrual hygiene practices, and the implications of reproductive maturity that is ushered in by menarche. This limited understanding can lead to poor health outcomes and the development of negative sentiments and beliefs surrounding the normal experience of menstruation.

This systematic review aims to comprehensively investigate the current state of research regarding the effects of school-based, formal menstruation education programs on adolescent girls, particularly the effects on anxiety and self-efficacy related to the management of menstruation. Furthermore, this work aims to take a stance …

Role Of C4 Resources In Isotopic Variability In Diet Among Children From Kellis 2 Cemetery, Dakhleh Oasis, Egypt, Faith R. Hendrix

Honors Undergraduate Theses

Using stable carbon isotope analysis, this study investigates dietary diversity in children buried at the Kellis 2 Cemetery (c. AD 50–450) in Egypt's Dakhleh Oasis. From the analysis of δ¹³C isotope values in hair keratin and bone collagen, the study reconstructs short-term and long-term dietary signals in juvenile and adult subjects. The aim is to clarify the role of C₄ plants—particularly millet—in weaning and childhood diets in a Romano-Christian Egyptian village context. A total of 631 segmented hair and 54 bone collagen samples were analyzed from 127 juveniles and 97 adults. Juvenile individuals (i.e., under 15 years biological age) showed …

Examining Perception Of Psychedelic Substances And The Role Of Hallucinations Among College Students, Ryann F. Hilts

Honors Undergraduate Theses

Inquiry into psychedelics is undergoing a cultural and scientific revival, driven by their potential application as novel treatments for mood disorders, substance misuse, and end-of life-distress, but continued implementation in clinical and medical contexts necessitates extensive research. The present study utilizes self-reported data to examine psychedelics across three areas: student attitudes, patterns of use, and motives for use. It additionally explores the perceived importance of hallucinations in therapeutic contexts and focuses on psychological experiences of those with lifetime psychedelic use. The study aimed to deepen understanding of current literature surrounding psychedelics, specifically among university students. Participants were asked to complete …

Cultural Competence In Pre-Medical Education: Examining Preparedness For Cross-Cultural Care, Fiza N. Khan

Honors Undergraduate Theses

As the U.S. population continues to grow more diverse, there is an urgent need for future healthcare providers to develop strong cultural competence. This study investigates undergraduate pre-medical students’ knowledge, attitudes, and comfort levels toward caring for diverse patient populations, including immigrants, refugees, and individuals from varied cultural backgrounds. The goal was to assess how well students are prepared to provide culturally responsive care before entering medical school. Recognizing that the foundation for medical training begins at the undergraduate level, this study aims to identify specific gaps in readiness that may hinder equitable patient care in the future.

A modified …

Partisan Divides In Environmental Spending Attitudes: A Two-Level Hierarchical Analysis, 1973-2022, Jordan Lipner

Honors Undergraduate Theses

Public attitudes toward environmental spending have become increasingly divided along party lines, with sharp shifts over the past five decades. This thesis updates and expands on Johnson and Schwadel’s 2019 study by applying a two-level hierarchical linear model to General Social Survey data updated to include data from 2015-2022, capturing how political affiliation, education, race, and economic context interact with broader political and economic contexts to shape environmental attitudes over time.
The results show that political affiliation remains the strongest and most reactive predictor of environmental spending attitudes. Republican respondents are significantly more likely to oppose environmental spending, especially under …

A Tail Of Two Fishes: Exploring Population Structure In Two Species Of Fishes Across The Galápagos Islands, Hillary Quach

Honors Undergraduate Theses

The Galápagos Islands, a UNESCO World Heritage Site and a biodiversity hotspot with high levels of endemism, is home to over 440 species of fishes. Marine conditions across the Archipelago are greatly influenced by ocean currents in the region. The Pacific Equatorial Undercurrent, South Equatorial Current, and the Humboldt Current deliver waters rich in nutrients across the three major regions within the Galápagos (central, north, and west). These conditions create a dynamic environment close to the equator, enabling diverse species to thrive in distinct parts of the Galápagos. Despite the rich biodiversity in the region and diverse oceanographic conditions, there …

“Some Small Kiss From Your Sweet Lips”: Navigating Hierarchy In Eastern Roman Letters, Nicholas Elijah Raffington

Honors Undergraduate Theses

The presence of homoeroticism in the letters of elite Byzantine men was both the product of long-term literary developments and was employed for many purposes. As a medieval society which saw a unique level of social mobility, an individual’s connections and how they managed and negotiated them within the competitive elite milieu was of utmost importance to their relevance. Letters naturally emerge as a suitable literary genre to affirm and recognize relationships, to ask for favors, or introduce a new member to the group. As the evidence suggests, homoeroticism was employed within the male-centered world of business and politics as …

Genomic Epidemiology Of Staphylococcus Aureus Sequence-Type 72, Sachitaa Senthilkumar

Honors Undergraduate Theses

Staphylococcus aureus (S. aureus, SA) is a gram-positive bacterial colonizer and pathogen commonly carried on the skin and in the anterior nares of humans. SA colonization may lead to a variety of non-invasive (e.g., skin and soft tissue infections, SSTIs) and invasive (e.g., bacteremia and osteomyelitis) infections. The SA population is comprised of multiple lineages that can be delineated through multi-locus sequence typing (MLST), which compares nucleotide sequences within seven housekeeping genes. Strains belonging to an MLST share a common evolutionary history and phenotypic characteristics like antibiotic resistance or virulence. As a result, the epidemiology of lineages can be …

Effects Of Changes In Strouhal And Reynolds Numbers On Beetle Wing Aerodynamics, Keith L. Thiha

Honors Undergraduate Theses

Insect flight has long been a subject of interest across the scientific community, largely due to the exceptional aerodynamic performance insects demonstrate relative to their size. Insects tend to have very high aerodynamic performance characteristics like thrust and lift generation compared to their size. This has many potential applications in improving aircraft performance, however the flow phenomena concerning insect wing aerodynamics is still an area of ongoing research. This study aims to investigate how variations in key nondimensional flow parameters—specifically the Reynolds number and Strouhal number—affect the aerodynamic performance of beetle wings. Strouhal numbers ranging from 0.2 to 0.6 were …

High-Throughput Drug Screening For Disease-Modifying Arthritis Therapy, Janapriya Vijayakumar

Honors Undergraduate Theses

Current therapy for arthritis predominantly focuses on the symptoms rather than the underlying causes of disease progression. Thus, it is necessary to identify novel drugs which target the underlying molecular basis of such diseases. Using high-throughput cell-based drug screening, we screened 458 different compounds, narrowed down from 811 starting compounds from the NIH Mechanistic Set. We selected drugs from the Mechanistic Set following Lipinski's Rule of 5 to ensure optimal pharmacokinetic properties. The study used modified primary human chondrocytes (IIAM-PRG4Luc), which secrete a lubricin promoter-driven luciferase reporter. We use this luciferase expression as a proxy to measure lubricin, a compound …

Investigation Of Lubricin-Stimulating Fda-Approved Compounds For A Disease-Modifying Osteoarthritic Drug, Swathi S. Menon

Honors Undergraduate Theses

Osteoarthritis (OA) is a degenerative disease that affects many people worldwide. Current methods of treatment are palliative, and no treatment exists to fully reverse or cure OA once it begins to progress. The discovery of a disease-modifying osteoarthritic drug (DMOAD) would increase the quality of life for millions and reduce the need for invasive procedures. Screening FDA-approved drugs ensures more promise due to their known safety profile and potential for faster translation to the clinic. The goal of this project was to conduct dose-response assays with FDA-approved drugs that have been shown to stimulate lubricin production in cells that mimic …

Active Musical Engagement Versus Passive Music Listening: Effects On Emotional Modulation, Claudia Allocca

Honors Undergraduate Theses

This study explored how different forms of musical engagement, actively playing versus

passively listening, impact emotional regulation following exposure to a stressor. The goal was

to better understand whether active participation in music offers greater emotional benefits

compared to simply listening, as previous research often highlights music’s role in emotional

modulation but overlooks the influence of performance-based engagement. A total of 28

participants either played music or listened to music and then completed both pre- and post-

stressor measures assessing mood, mental task load, and heart rate. Contrary to the original

hypothesis, findings revealed that participants from the listening group …

Development Of A Proposed Selective Medium For The Isolation And Differentiation Of P. Sordellii, Dimyana Bottros

Honors Undergraduate Theses

Clostridium, a genus of anaerobic, spore-forming bacteria, includes clinically and ecologically significant species like Clostridium difficile and Paeniclostridium sordellii. C. difficile causes antibiotic-associated colitis, while P. sordellii is linked to fatal infections and spontaneous abortions. Recent studies found both species in marine sediments, suggesting their role in environmental and wildlife health disturbances, including the 2013 mass mortality of over 300 manatees in the Indian River Lagoon. However, isolating and differentiating P. sordellii is challenging due to the lack of selective media optimized for its growth. This thesis proposes a novel selective medium tailored to P. sordellii’s physiological …

Allele-Specific Pcr (As-Pcr) Assays For Genetic Variants Associated With Color Morphs In Ball Pythons (Python Regius), Uyen Dao

Senior Honors Theses and Projects

While the genetic basis of color morphs in ball pythons (Python regius) has become increasingly studied, rapid and accessible tools for genotyping these known mutations are still limited. Here, we developed allele-specific PCR (AS-PCR) assays for detecting genetic mutations associated with ten diUerent P. regius color morphs, providing a rapid and coste Uective genotyping tool. We first tested each color morph with diUerent combinations of AS-PCR primers to determine the optimal ones. Then, we performed AS-PCR again with a larger sample set after identifying optimal primers and amplification conditions specific to each morph-associated genetic variant. These AS-PCR assays distinguished wild-type …

Plantation Matters: The Black Production Of Space In Southeastern Louisiana, 1830 To 1912, Noura Jabir

Pomona Senior Theses

Taking one Louisiana sugar plantation as a starting place, I demonstrate how African-descended laborers created life-sustaining spaces within/beyond the death-driving plantation complex during and after slavery.

“Regression To The Mean”: The Confluence Of Eugenics And Statistics In The 19th And 20th Centuries, Emrys G. King

Pomona Senior Theses

The work of this thesis is twofold — first, qualitatively characterizing the confluence between the British eugenics and statistics movements in the late 19th and early 20th centuries, and second, quantitatively analyzing the effect of this foundation on pedagogical materials in the growing field of statistics between 1880 and 1970. Towards the first goal, the history of the method of least squares, state statistics, and positive and negative eugenics are outlined, followed by a close reading of the foundational texts authored by Francis Galton and Karl Pearson that introduced linear regression. Towards the latter goal, English-language statistics textbooks published between …

From Feedlot To Floor Vote: ​​How Animal Agribusiness Wields Power To Capture The American State, Hannah Hughes

Pomona Senior Theses

This thesis examines how large-scale animal agriculture operations exercise disproportionate political influence to shape regulatory policy in their favor, often at the expense of environmental protection and public health. Through analysis of concentrated animal feeding operations (CAFOs), this study demonstrates how the animal agribusiness industry has systematically captured regulatory processes at federal, state, and local levels. The research traces industrial animal agriculture's development in the 21st century and its environmental consequences. The analysis reveals significant gaps in federal oversight, examining how the Clean Water Act and Clean Air Act have proven inadequate in regulating CAFO operations. At the state level, …

Biomechanics Of The Atherosclerotic Lipidome: (Un)Expected Statin Interactions And Membrane Remodelling, Ethan M. Fong

Pomona Senior Theses

Statins interact with lipid membranes in ways that shape their pharmacokinetics, off-target effects, and pleiotropic actions, yet these interactions' mechanical and biophysical consequences remain poorly understood. This thesis employs a combination of surface plasmon resonance (SPR), quartz crystal microbalance with dissipation monitoring (QCM-D), and rheological modelling to characterize how representative statins intercalate within biomimetic supported lipid bilayers (SLBs) of healthy and diseased composition. SPR reveals that lipophilic statins exhibit higher apparent affinities and slower dissociation kinetics, especially in cholesterol- and anionic lipid-rich membranes. QCM-D analyses demonstrate that statins alter membrane mass, dissipation, and interfacial stiffness in a statin- and membrane-dependent …

The Serendipity Of Discovery: Life Of A Geochemist, Willard S. Moore

Faculty Publications

My strategy for writing this autobiography is to use examples of how working on seemingly different projects can often lead to outcomes more important than originally envisioned. Serendipity is a "happy accident"; specifically, the accident of discovering something useful without directly looking for it. This often occurs when two research projects converge unexpectedly. The main text contains examples of how serendipity has led me to important discoveries including: (a) finding surprisingly high ²²⁸Ra activities in the ocean, (b) developing a means of rapidly and quantitatively extracting radium from seawater, (c) devising a rapid, sensitive method of measuring ²²⁴Ra …

Development Of A Scituate Reservoir Mitigation Model For Assessing Flood Control During Extreme Scenarios, Supria Paul

Open Access Dissertations

Effective reservoir management is essential for mitigating downstream flooding, especially with the increasing frequency and intensity of extreme weather events impacting major drinking water reservoirs such as the Scituate Reservoir in Rhode Island. These reservoirs provide water for large populations but can be overwhelmed by intense precipitation, flooding and land cover changes. Climate change is expected to increase precipitation in the study area located in New England, highlighting the need for improved reservoir systems, especially given the aging dams and higher risk of failures. Additionally, land cover changes, like the widespread defoliation caused by the Gypsy Moth infestations, affect water …