Digital Commons Network^™

Structural Studies Of Cellular Prion Protein And Amyloid-B Oligomers, Lauren Klein

Yale Graduate School of Arts and Sciences Dissertations

Alzheimer's Disease (AD) is a neurodegenerative disease with significant societal impacts. AD is the only top ten leading cause of death that cannot be prevented, cured, slowed, or even diagnosed before symptoms are present. AD, similar to other neurodegenerative diseases, has been linked to protein aggregation as the key factor in the disease pathology. However, the mechanism by which AD proliferates is poorly understood. Recent advancements in techniques and methods in structural biology, including nuclear magnetic resonance (NMR) and electron microscopy (EM), have opened a new era of studies into protein aggregates implicated in neurodegenerative diseases, including AD. Therefore, this …

The Tenth Anniversary Of Marriage Equality: How Traditional Marriage Law Led To Constitutional Protection For Same-Sex Marriage, Joanna L. Grossman

Faculty Journal Articles and Book Chapters

This essay explores how the history of interstate marriage recognition law was central to the Supreme Court’s recognition of constitutional protection for the right of same-sex couples to marry. Prior to the 1990s, there were essentially no laws on same-sex marriage in the United States. That changed in the 1990s, when the Hawaii Supreme Court issued a ruling in Baehr v. Lewin that made authorization of same-sex marriage seem inevitable in that state. The threat fueled the adoption first of the federal Defense of Marriage Act (DOMA) in 1996 and then mini-DOMAs in most states. Those laws were broad and …

Studies Towards Improving Ni-Catalyzed Cross-Electrophile Coupling Reactions, Haotian Huang

Yale Graduate School of Arts and Sciences Dissertations

This thesis summarizes work towards improving Ni-catalyzed cross-electrophile coupling reactions through the development of new homogeneous organic electron donors and the understanding of ligand effects on key proposed elementary steps. Chapter 1 provides an overview of the current use of homogeneous organic electron donors and mechanistic understanding in Ni-catalyzed cross-electrophile coupling reactions. Chapter 2 describes the development of two new types of homogeneous reductants and their catalytic relevance. Chapter 3 details the effects of 6,6′-substituents on bipyridine-ligated Ni catalysts for cross-electrophile coupling. Chapter 4 describes progress towards understanding ligand effects on alkyl radical capture at NiII complexes, a key elementary …

2025 Annual Report, Tennessee. Division Of Forestry And Tennessee. Department Of Agriculture

Forestry Annual Reports

This annual report presents an overview of Tennessee Forestry Commission programs and management.

Gene Expression Regulation By Pabpn1 Phosphorylation And Microexon Splicing, Jackson Miles Gordon

Yale Graduate School of Arts and Sciences Dissertations

The processing of pre-mRNAs into mature mRNAs is a key regulatory step in eukaryotic gene expression programs. Before an mRNA can be exported to the cytoplasm, its 5′ end must be modified with a 7-methylguanosine cap structure, intervening non-coding sequence must be removed (spliced), and a poly(A) tail must be synthesized at its 3′ end. Each of these processes are dynamic and provide contextual regulation, tuning an mRNAs coding capacity, stability, and translation potential as needed. The Neugebauer Lab has developed highly specialized tools to dissect how RNAs are spliced, cleaved, and polyadenylated in numerous biological systems. In this study, …

Children And Chairs, Artifacts And Reality, Adam J. Macleod

Scholarly Articles

Where do children come from? The source of childhood—either nature or political will—is a matter not merely of chronology but of authority. Whoever makes children gets to define childhood. Legal childhood is one type of legal personhood. Legal personhood matters because legal persons bear legal rights and duties. Rights and duties direct how we act toward each other. Thus, our ideas about how persons come to be, who counts as a person, and how persons are defined in law determine in large part how we act toward persons, both other persons and ourselves.

A legal person is an artifact of …

Quantifying Modifiable Lifestyle Behaviors And Influences Associated With Preventable Cancers In Selected Rural Counties: A Mixed Method Study, Jecinta Scott

Dissertations and Theses

Cancer is the second leading cause of death in the United States disproportionately affecting rural communities. This dissertation study investigates the involvement of rural communities in lifestyle behaviors associated with increased risk of cancers, the impact of socioeconomic factors, and what influences their behavior and the impact of political party affiliation. The study was conducted using a mixed-method quantitative data analysis enhanced by qualitative interviews. It began with an extensive literature review to identify existing research, and evidence gaps on the topic. Data collection involved retrospective quantitative extraction from the Centers for Disease Control and Prevention’s Behavioral Risk Factor Surveillance …

Indigenous Reconciliation And Development, Diane Francis, Wenona T. Singel, Wayne Garnons-Williams

Canada-United States Law Journal

A panel discussion on efforts to provide reconciliation and developmental opportunities to indigenous people, especially in Canada and the United States.

Survival Of The Fittest? Ai And Its Different Regulatory Models, Miklós Király

Emory International Law Review

Prof. Peter Hay is a regular visitor to Budapest, Hungary. He gives excellent lectures on conflict of laws, with a particular focus on the nuances of jurisdiction. At the same time, many of us are avid readers of his German textbook US-Amerikanisches Recht. This textbook provides an overview of US law, from legal history to constitutional law and administrative law or criminal law. His interest and work which spans legal disciplines and legal systems, encourages me to welcome him with a paper on comparative law than a study of private international law.

This paper provides an overview of the broad …

Precautionary Measures And The Risk Of Escalation In The Use Of Nuclear Weapons, Jeffrey Biller

Emory International Law Review

The use of nuclear weapons presents an unparalleled risk of escalation, a reality that has become increasingly pressing due to recent geopolitical developments, particularly Russia’s revised nuclear doctrine and its ongoing conflict with Ukraine. While the legal frameworks governing armed conflict, particularly International Humanitarian Law (IHL), do not traditionally require an analysis of escalation risk before an attack, this article argues that the extreme and immediate consequences of nuclear escalation necessitate its inclusion within the precautionary measures framework.

This article first examines the concept of nuclear escalation, identifying both intended and unintended risks associated with nuclear strikes. While nuclear deterrence …

Cyberbullying As A Contemporary Human Rights Violation Of Youth In Digital Media: A Study Of India, Brazil, And South Africa, Laura Ferla Tuma

American University International Law Review

The COVID-19 pandemic facilitated a technological migration not only among adults but also among children and adolescents. Digital media became the alternative for young individuals to maintain their activities, especially school-related ones. They shared virtual classrooms, used the internet for entertainment, and were forced to socialize exclusively in digital environments for months. Connected time increased, and the world witnessed a new phenomenon: hyperconnectivity.

Is It Possible To Draft A Universal Criminal Code?, Paul H. Robinson

American University International Law Review

The world contains hundreds of distinct communities with their own traditions and values. One might assume that, despite the best efforts of international organizations, it would be impossible to draft a criminal code that could operate effectively for all countries. Is that the case? If one tried to construct a universal criminal code, what sorts of challenges and limitations with the effort face?

Epigenetic Regulation In Fibrosis, Qingping Wei, Xiaoru Hu, Yan Sanders

Department of Biomedical and Translational Sciences Faculty Publications

[Introduction] Fibrosis is one of the pathological conditions underlying the progression of numerous chronic diseases, and it contributes substantially to morbidity and mortality worldwide. Increasing amounts of evidence indicate that epigenetic mechanisms—including DNA methylation, histone modifications, RNA modifications, and non-coding RNAs—play pivotal roles in epithelial cell injury and maladaptive tissue repair, inflammatory cell and fibroblast activation, and extracellular matrix remodeling and accumulation. Compared to genetic alterations, epigenetic changes are relatively reversible, positioning them as promising therapeutic targets. The articles collected in this Research Topic highlight recent advances in understanding how epigenetic regulation shapes fibrotic processes across multiple organ systems and …

The Blue Economy Comes To Green Creek, Ursula Ramsey

South Carolina Journal of International Law and Business

Oceans, touted as the “next great economic frontier,” are projected to contribute three trillion dollars to the global economy. Beyond their economic potential, oceans provide a host of environmental benefits: oceans supply over half of the planet’s oxygen and contain nearly all of the Earth’s water and biosphere. Especially because the high seas represent one of the few remaining global commons, oceans present a governance challenge. Meeting this challenge is the concept of the blue economy, a form of governance that combines environmental stewardship, economic development, and social equity. This article, in discussing Mulvihill v. South Carolina Department of Health …

Optimization Of Free-Time Controlled Constrained Sweeping Processes And Applications, Thi Dai Trang Nguyen

Wayne State University Dissertations

Optimization and optimal control have a wide range of applications across fields like engineering, biology, data science, and economics. This dissertation is devoted to advanced optimal control problems discontinuous constrained differential inclusions of the sweeping type involving the duration of the dynamic process into optimization, which are truly challenging and underinvestigated in control theory while being highly important for various applications. To attack such problems, we use the method of discrete approximation while establishing its well-posedness and strong convergence to optimal solutions of the controlled sweeping process. This approach, married to advanced tools of variational analysis, enables this research to …

An Exploration Of Inquiry-Based Learning: Effects On Critical Thinking, Engagement, And Achievement, Madelyn J. Mehr

All Electronic Theses and Dissertations

This thesis explores the effects of inquiry-based learning on three key student outcomes: critical thinking, engagement, and academic achievement. Drawing on studies from which the methodology was applied across K-12 and higher education settings, this review summarizes empirical findings to identify strengths and limitations. Inquiry-based learning is frequently associated with improvements in student participation and reasoning skills due to its emphasis on providing opportunities for hands-on investigative processes and collaborative work; however, the magnitude of these effects varies based on the type of inquiry-based learning used and the level of instructional support. In this paper, literature was reviewed on different …

Balancing Innovation And Attention: A Review Of Digital Distraction, Self-Regulation, And Technology Policy In Modern Classrooms, Kayla R. Schlichting

All Electronic Theses and Dissertations

This literature review examines how digital technology influences student attention, engagement, and self-regulated learning in 1:1 classrooms. Across 30 studies, technology is deemed neither inherently harmful nor helpful; rather, its impact depends on how technology is used and the instructional design the educator employs. Digital distractions, such as smartphones, multitasking, and peer interruptions decrease focus and negatively impact academic performance. However, strategies such as goal setting, structured note-taking, reflection, and feedback loops help students develop greater self-regulation and manage their engagement. Overall, this review emphasizes the need for clear and consistent expectations, well-designed technological lessons, and intentional instruction, especially as …

Nature-Based Learning In Visual Arts Education, Ava D. Raisanen

All Electronic Theses and Dissertations

This literature review and application thesis examines the concerns related to nature-deficit, specifically screen usage, student disengagement, and mental health issues. This review examines how nature-based educational approaches can enhance mental health, improve academic performance, and connect to various topics, including Indigenous culture and interdisciplinary art approaches that integrate multiple subjects. The lesson plans provided in the application are rooted in culturally relevant, nature-based approaches for students in grades K-12, including an Indigenous-inspired lesson for elementary, middle, and high school art.

Image Analysis Using Smartphones: Relationship Between Leaf Color And Fresh Weight Of Lettuce Under Different Nutritional Treatments, Hye Su Won, Eunji Lee, Seeun Lee, Ji-Hyeon Nam, Jiwon Jung, Yuna Cho, Thomas Evert, Noah Kan, Steven Kim, Dong Sub Kim

Mathematics and Statistics Faculty Publications and Presentations

Image analysis can be useful for assessing crop health and predicting yield. Instead of expensive equipment, smartphones are considered an accessible and low-cost alternative. The objectives of this study were to evaluate whether fresh weight in green and red lettuce could be predicted by leaf color (intensity of green color measured by RGB) under different fertilizer treatments using RGB imaging from two widely used smartphone models (Samsung Galaxy and Apple iPhone). The two smartphones showed similar longitudinal patterns of RGB data (the intensity and dark green proportion), but the absolute difference in the RGB data was significantly different. Therefore, the …

In Search Of A Sea-Life Balance In An Adverse Environment : Understanding Seafarers’ Life, Work And Turnover : Phase One: Interview Results, World Maritime University

Reports

This report constitutes the qualitative part (i.e Phase One) of the research project “Work & Health Balance at Sea” (WHEAB). It explores the experiences of 20 officers and engineers, primarily from the United States, across eight core areas.

Bs Engineering Technology, Manuf And Cad 2025-26, Arkansas State University - Jonesboro

Bachelor of Science and Education

Manufacturing and Computer Aided Design (CAD) Emphasis

Bsce, Civil Engineering 2025-26, Arkansas State University - Jonesboro

Bachelor of Science and Education

No abstract provided.

Bs Biological Science, Eeob 2025-26, Arkansas State University - Jonesboro

Bachelor of Science and Education

Evolution, Ecology & Organismal Biology

16th Sunday In Ordinary Time - 20 July 2025, Pina Ford

Pastoral Liturgy

No abstract provided.

Tbi Semi-Annual Report - July-December 2024 Final.Pdf, Tennessee. Bureau Of Investigation

Annual Reports

This document is the annual report for the TBI during the fiscal year.

Tdec 2025 Annual Report, Tennessee. Department Of Environment And Conservation

TDEC Annual Reports

This annual report highlights the accomplishments of the Tennessee Department of Environment and Conservation over the fiscal year.

The State Of The Child In Tennessee 2025, Tennessee Commission On Children And Youth

Kids Count/State of the Child in Tennessee Reports

This report provides an overview of information on healthy infants, children and teens; child/teen well-being; education; economic security; and demographics.

Study On Motion Prediction Analysis Of Large Vessels Entering Kaohsiung Port Second Harbor, Li-Heng Cheng, Hsing-Yu Wang

Journal of Marine Science and Technology–Taiwan

Pilotage is a primary service offered by ports, ensuring the safe passage of entering and exiting vessels. This study applied motion prediction analysis to large vessels navigating the constrained waterways of Kaohsiung Port’s second harbor. To address the needs of pilots and port operators, a simplified planar motion equation was developed that incorporated speed over ground and rate of turn (ROT) as primary variables. The model relied on inputs of limited navigational data, enabling pilots to predict changes in heading and position over time and determine the conditions for safe harbor entry. Vessel paths and turning angles were analyzed to …

2025 Stem Research Showcase Program, Seattle University

STEM Research Showcase Programs

No abstract provided.

Pulse X

Pulse Magazine Archive

No abstract provided.