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Pregnancy Outcomes After Glp-1 Receptor Agonist Exposure And Ethical Considerations, Nishita Pondugula

Yale Medicine Thesis Digital Library

The objective of this study is 1) to understand the effect of GLP-1 receptor agonist (GLP-1RA) use in the year prior to conception on risk of developing hypertensive disorders of pregnancy (HDP) and on gestational weight gain (GWG), and 2) to analyze important ethical considerations relevant to research in pregnancy and specifically related to GLP-1RAs.All patients delivering between 2014-2024 with evidence of GLP-1RA exposure in the year prior to conception were identified through electronic medical record (EMR) query with hand review to confirm exposure. GLP-1RA exposed patients were classified according to GLP-1RA indication for use: 1) pregestational diabetes mellitus (PGDM) …

Macrophage Migration Inhibitory Factor And D-Dopachrome Tautomerase As Biomarkers And Key Modulators Of Tumor Progression In Head And Neck Cancer And Melanoma, Caroline Naomi Valdez

Yale Medicine Thesis Digital Library

Macrophage Migration Inhibitory Factor (MIF) and its homolog D-dopachrome Tautomerase (DDT) are pro-inflammatory cytokines implicated in tumor progression across multiple cancers. Both MIF and DDT act through canonical CD74 and non-canonical CXCR2/4/7 signaling pathways, which contribute to immune suppression and tumor progression. Elevated MIF levels are associated with metastasis and poor prognosis in HNC and contribute to immune checkpoint inhibitor (ICI) resistance in melanoma. DDT’s role in cancer is not well understood. This study aims to evaluate the expression and therapeutic potential of MIF and DDT inhibition, focusing on their ability to modulate immune responses and improve survival outcomes as …

Bipolar Disorder Among Individuals With Atopic Dermatitis: A Case-Control Study In The All Of Us Research Program, Mitchel Wride

Yale Medicine Thesis Digital Library

Background: Atopic dermatitis has been associated with psychiatric comorbidities.Objectives: To characterize the association between atopic dermatitis and bipolar disorder with a case-control study of the NIH All of Us Research Program. Methods: Utilizing Systemized Nomenclature of Medicine diagnostic codes, we identified cases of atopic dermatitis. Four age, sex, and race/ethnicity matched controls were found for each case using propensity score matching. After controlling for age, sex, race/ethnicity, income, smoking status, and depression, the relationship between atopic dermatitis and bipolar disorder was evaluated using logistic regression. Results: We identified 13,431 atopic dermatitis cases with 53,724 matched controls. Participants with atopic dermatitis …

Endoscopic–Assisted Surgery For Cerebello Pontine Angle Pathology: Technical Note And Surgical Results In A Series Of Patients, Jaime Jesus Martinez Anda, Pablo David Guerrero Suarez, Diego Pineda Martínez, Rafael Avendaño Pradel, Ernesto Javier Jurado Delgado, Ricardo Santiago Villlagrana Sánchez, Juan Carlos Cisneros Lesser, Carolina De La Llata Segura, Rogelio Revuelta Gutiérrez

Archives of Neurosurgery

Objectives: Endoscopic–assisted surgery combined with the operating microscope has been described for several surgical techniques and pathologies of the cerebellopontine angle (CPA). The use of an endoscope allows for a panoramic view of the CPA cistern and a high degree of maneuverability in narrow cisternal spaces that enable the surgeon to deal with most CPA lesions safely. We performed an observational study to describe the surgical anatomy and technique for endoscopic-assisted CPA surgery, describing our experience in a case series of patients with CPA pathology. Methods: Anatomical and surgical technique description of endoscopic-assisted surgery for CPA pathology, based on observations …

Fall Wonders, Arizona State University

Wildlife/Nature

Photographs, Bibliography, and Collection Description for a display of government documents from Fletcher Library at Arizona State University.

Analyzing Contributing Factors To Obesity Rates In Ohio, Lillian Davis, Zach Hurley

Scholarship in Medicine - All Papers

Obesity, along with its comorbidities, has been significantly increasing worldwide for the pastfew decades. Our objective in this report is to investigate several factors that may be contributingto obesity rates in Ohio, specifically physical inactivity, access to healthy foods, and living in arural/urban county. Using data from the Ohio County Health Rankings for 2016 and 2023, wewere able to analyze the differences in obesity rates between rural and urban Ohio counties(RQ1), compare how access to healthy foods have changed over time in Ohio (RQ2), determinewhether there is a correlation between obesity and access to healthy foods for Ohio counties(RQ4), and …

Characterization Of Legionella Pneumophila Effector Protein Ceg10, Emmanuella Ofoka

Masters Theses & Specialist Projects

Legionella pneumophila, the causative agent of Legionnaires' disease, utilizes a Type IV secretion system (T4SS) to transport effector proteins into host cells. This bacterium is said to have over 300 effector proteins. Among these, the Ceg10 effector protein had remained uncharacterized, despite evidence suggesting the importance of bacterial effector proteins in the host-pathogen interaction. This study aimed to perform a structural and functional characterization of Ceg10 through transcriptomic, bioinformatics, and molecular analyses. Transcriptomic profiling of HEK 293T cells expressing Ceg10 revealed significant differential gene expression, with approximately 20 upregulated genes, including leucine-rich repeat, as well as other downregulated genes. …

Person-Centered Planning: An Improvement Science Approach To Interventions Impacting Teacher Implementation, Stacie Hutchison

Masters Theses & Specialist Projects

This study used an improvement science framework to influence special education teachers’ behaviors and their implementation of transition service development through person centered planning and ongoing teacher support. Grounded in adaptive leadership principles and a theory of action emphasizing the need for new professional learning and sustained support, this research investigated how targeted interventions impact teacher practice.

I selected a mixed-methods design for this study, combining semi-structured interviews, Likert scale surveys, open-ended questions, and a single-participant case study to evaluate outcomes. Findings revealed that a traditional professional development model incorporating opportunities to practice skills and proactively address potential barriers led …

Expanding On The Relationship Between Incivility And Resource Depletion: Examining Race And Personal Tolerance For Mistreatment As Moderators, Aishwarya Kurmar

Masters Theses & Specialist Projects

Workplace incivility is ubiquitous, regularly impacting working adults. Through the framework of Conservation of Resources (COR) theory, I examined the relationship between workplace incivility and resource depletion using daily diary methodology. Workplace incivility negatively impacts employee outcomes at the organizational and individual level. As such, it was hypothesized that workplace incivility would have a positive correlation with increased resource depletion, measured as psychological fatigue. Under selective incivility theory, disenfranchised groups face increased instances of incivility. Following this theory, non-whites were hypothesized to experience a greater association between workplace incivility and resource depletion. Additionally, an individual’s personal tolerance of mistreatment for …

Developing Phenanthroimidazole-Based Fluorescent Sensors For Efficient Analyte Detection, Brian Kellogg

Masters Theses & Specialist Projects

The highly efficient design and synthesis of organic fluorophores with an excellent quantum yield have received extensive attention. Compared with instrumental techniques, fluorescent sensors derived from organic small molecules offer many impressive benefits, such as selective detection, lower cost, and higher efficiency. Various detection mechanisms such as colorimetric, ratiometric, and fluorescence turn on/off have been reported for single analyte detection. Developing molecular probes that are capable of detecting two (or more than two) different analytes (cations, anions, and/or biomolecules) had emerged as a new research area and attracted considerable attention in the field of chemo- and biosensors.

Phenanthroimidazole represents a …

Diversity And Phylogeny Of Spider Beetles (Ptinidae: Ptininae) In Coastal Chile And Peru, Jacob Bowen

Masters Theses & Specialist Projects

Spider beetles of South America have historically received little systematic study, though now they are the subject of recent diversity surveys and documentation. This investigation contributes to the ongoing exploration of spider beetle diversity in South America by adding records for the recently described Cordielytrum and the yet to be described Furcillifer, as well as constructing phylogenies with new genetic material. MaxEnt was used to create an ecological niche model revealing habitat suitability in Chile and Peru for Cordielytrum, a genus of flightless spider beetles currently known only from Peru. Even with few occurrence records, a model with …

Visualizing And Analyzing The Growth Of Dark Septate Fungi Within Plant Roots, Sophia Mcdade, Mac Johnson, Ilana Fay Zeitzer, Anthony Yannarell

MICRO-CCS student projects

• Plants rely heavily on relationships between plant roots and root associated symbionts like bacteria and fungi
• Arbuscular mycorrhizal fungi (AMF) can help plants take up nutrients and limit the uptake of heavy metals
• Previous AMF experimentation in lab led to observation of high quantities of dark septate fungi (DSF) in cold stored roots
• DSF are far less researched than AMF; have melanized and septate hyphae, found to colonize roots worldwide, but growth patterns and potential functions are not yet understood

Nsu Outreach, Nova Southeastern University

NSU Digital: Communiversity

No abstract provided.

College Students’ Beliefs: Association Between Skin Color And Acceptance, Christopher James Thompson

Theses and Dissertations

The Multiracial population represents the fastest-growing demographic group in the United States and is expected to more than double by 2060 (Vespa et al., 2018). Despite this rapid increase in the Multiracial population, there is a dearth of research regarding racial identity development, anxiety, and depression on this group. Social inclusion has been recognized as a fundamental human need, and Multiracial individuals may be more likely to be accepted into a majority group if their appearance is racially ambiguous. The current study builds on previous knowledge by utilizing a novel measure developed to examine the beliefs held by Monoracial and …

Techbio Industries: Healthcare Manufacturer Takes A Strategic Leap During The Covid-19 Pandemic, Vafa Saboorideilami, Chang Seob Yeo, Sarah Lee, Yung-Jae Lee

Barowsky School of Business | Case Studies

Charles "Chuck" Benson, CEO of TechBio Industries, recollected an early Monday morning in March 2019 when he boarded a flight from San Francisco to Philadelphia to meet with the CEO of MedX Supply Chain. During the meeting, MedX requested TechBio to cut prices by 15%, threatening to source their products from a Chinese manufacturer. MedX reasoned that 60% of the market did not care about the quality of disposable lab products. Consequently, TechBio lost most of MedX's contracts, causing their sales to drop from $40 million to $30 million in about a year.

Effect Of Praziquantel Treatment On The Nutritional Status Of Children Infected With Schistosoma Haematobium, Louis Fok, Hongying Dai, David Brett-Major, Abebe Animut, Berhanu Erko, John Linville, Yohannes Negash, Abraham Degarege

Journal Articles: Epidemiology

This quasi-experimental trial examined the relationship between Schistosoma haematobium infection and nutritional status, and the impact of single dose praziquantel (PZQ) therapy on undernutrition. A total of 353 children were examined, 112 of which were infected with S. haematobium and treated with PZQ. Children's heights, weights, and mid-upper arm circumferences (MUAC) were measured at baseline and one month post-treatment. Infected children had significantly smaller mean BMI-for-age z-scores (BAZ) (-1.16 vs. 0.11, p < 0.01) and weight-for-age z-scores (WAZ) (-0.61 vs. -0.31, p = 0.03) than the uninfected ones at baseline. S. haematobium infection was associated with underweight (adjusted OR: 1.76, 95% CI: 1.63-1.90). One month after treatment, BAZ, WAZ, …

Delineating Ecologically Distinct Groups For Annual Cycle Management Of A Declining Shorebird, E. C. Knight, J. Carlisle, A. J. Boyce, D. Bradley, P. Cimprich, S. Coates, L. A. Powell Et Al.

School of Natural Resources: Faculty Publications

No abstract provided.

Challenges In Public Health: The Diagnosis And Treatment Of Crusted Scabies, Marshall Hall, Alyssa Forsyth, Wenquin Du, Michael Carletti, Stephen Weis

North Texas Research Forum 2025

Introduction: Common scabies is a parasitic dermatologic condition that often presents as an extremely pruritic rash. A rare and highly contagious variant of common scabies is crusted scabies, formerly known as Norwegian scabies. While infection with common scabies typically involves 10 to 20 mites, individuals with crusted scabies are burdened with thousands to millions of mites. Crusted scabies is characterized clinically by hyperkeratotic papules and plaques, most commonly on the palms and soles. Due to the variety of presentations seen in scabies, it can be difficult to diagnose. Case presentations: We present 4 cases of crusted scabies. An 89-year-old male …

Icipe Annual Report 2024, International Centre Of Insect Physiology And Ecology (Icipe)

icipe Annual Reports

No abstract provided.

Profile: Innovation Through The Liberal Arts, Communications And Marketing

Profile (1996-)

In this issue: Alumnus Chooses to Pay It Forward with Scholarships ; Gallant Makes the Most of Scholarships ; Newell Gives Back with Entrepreneurship Class ; Giving Allows Students to Get Business Ownership Experience ; Competitive Ethics Team Earns National Bid ; Tollefsrud Named Fulbright Finalist ; Noujdi Receives 2024 Undergraduate SEED Award ; Faculty and Staff Awards ; Hands-On Observatory Experience for Physics Students ; Zavada, Students Travel to Peru for Fulbright Research ; Morris Model Wins Second Department of Energy Competition ; 2025 Commencement ; Spotlight: Highlighting the Degree in Three Option ; AI Philosophy Tutor: Using AI …

Lawrence University Course Catalog, 2025-2026, Lawrence University

Course Catalogs

No abstract provided.

“Science Belongs Everywhere”: Outlooks On Post-Secondary Stem Education For Correctional Centers In Virginia, Shelita R. Augustus

Division of Strategic Enrollment Management and Student Success Publications

Virginia has an incarceration rate of 679 per 100,000 residents, the highest among independent democratic nations. This scoping review examines perspectives on post-secondary STEM education to promote STEM education within Virginia's correctional facilities, assesses programs to improve rehabilitation, reduce recidivism, and address systemic inequalities by developing the scientific potential of incarcerated individuals. The review finds that while STEM education in correctional facilities faces limitations, its potential benefits are being realized nationwide. Virginia has made strides through initiatives like House Bill 2158, which aims to expand higher education access for incarcerated individuals. Examples such as the programs at J. Sargeant Reynolds …

Caves, Calculus, And Climate Change: Measuring And Modeling The Discharge Of Biz Falls In Mammoth Cave National Park, Ava Lich

Mahurin Honors College Capstone Experience/Thesis Projects

Climate change poses a significant global challenge, with increasing levels of atmospheric carbon dioxide as a primary driver of rising temperatures and environmental disruptions. Karst systems, such as those in South-Central Kentucky, play a role in sequestering atmospheric CO₂ through the dissolution of limestone, a process that forms unique landscapes while mitigating climate impacts. This study investigates the discharge dynamics of Cascade River in Great Onyx Cave to enhance understanding of the relationship between hydrology and carbon sequestration in karst environments. A barrel weir equipped with pressure transducers was employed to collect and measure water flow, and Torricelli’s law was …

Assessing Nitrous Oxide Flux In Denitrification-Inhibiting Maize, Emma Mccullough, Sakshi Paudel, Holly Anderson, Angela D. Kent

MICRO-CCS student projects

• Conventional agriculture relies heavily on nitrogen (N) fertilizers to increase short-term crop yields.
• Microbial nitrification and denitrification drive N losses from soil systems.
• Denitrification produces N O, a potent green house gas (GHG).
• Biological denitrification inhibition (BDI) traits are present in the ancestor of modern maize, teosinte.
• Reintroduction of BDI traits into modern maize can reduce GHG production and increase nutrient use efficiency (NUE) as it minimizes soil N losses from denitrification.
• Monitoring N O emissions from BDI-introgressed maize lines can asses GHG reduction and potential NUE gains.

Does Phage Resistance Trade Off With Plant Symbiosis Rhizobia?, Cole Maxwell, Chase Schwarz, David Vereau Gorbitz, Hunter Cobbley, Andrew Buechler, Carin Vanderpool, Katy Heath

MICRO-CCS student projects

o The Heath Lab studies the evolution of plant-microbe symbioses using the legume-rhizobia system as a model

o Rhizobia form an association with legumes, converting atmospheric nitrogen into a useable form for the plants

o Trifolium pratense and Rhizobium leguminosarum form the system used here

o External factors drive R. leguminosarum evolution beyond plant association

o I study the impact phage defense systems have on Rhizobium leguminosarum partner quality

o Three wild type strains were experimentally evolved to produce three mutant strains each that were newly resistant to phage (Figure 1).

o These resistant strains had mutations affecting exopolysaccharide (EPS) …

2024-2025 Library & Learning Annual Review, Library & Learning, Minnesota State University, Mankato

Library & Learning Annual Reviews

Digital version of the 2024-2025 Annual Review for Library & Learning at Minnesota State University, Mankato.

Population Increases Of The Threatened American Burying Beetle (Nicrophorus Americanus) Linked To Large-Scale Collaborations In A Working Lands Ecoregion, C. P. Roberts, A. K. Ludwig, D. T. Fogarty, E. F. Stuber, Daniel R. Uden, T. L. Walker Jr., D. Twidwell

School of Natural Resources: Faculty Publications

No abstract provided.

A Plain Language Summary Of The Final Analysis Of The Griffin Study Of Daratumumab Plus Lenalidomide, Bortezomib, And Dexamethasone For People With Newly Diagnosed Multiple Myeloma., Peter M Voorhees, Douglas W Sborov, Jacob Laubach, Jonathan L Kaufman, Brandi Reeves, Cesar Rodriguez, Rebecca Silbermann, Luciano J Costa, Larry D Anderson, Nitya Nathwani, Nina Shah, Naresh Bumma, Yvonne A Efebera, Sarah A Holstein, Caitlin Costello, Andrzej Jakubowiak, Tanya M Wildes, Robert Z Orlowski, Kenneth H Shain, Andrew J Cowan, Shira Dinner, Katharine S Gries, Huiling Pei, Annelore Cortoos, Sharmila Patel, Thomas S Lin, Saad Z Usmani, Paul G Richardson

Oncology Articles

No abstract provided.

Navahine V. Hawai'i Dept. Of Transportation: The Keiki Will Lead Us, Catherine Smith

Scholarly Articles

The author analyzes the landmark case Navahine v. Hawaiʻi Department of Transportation, which culminated in the world’s first constitutional climate settlement. Catherine Smith, serving as an expert for the youth plaintiffs, situates the case within Hawaiʻi’s legal tradition of prioritizing children’s rights and intergenerational equity. She explores the evolution of children’s constitutional protections, contrasting Hawaiʻi’s progressive jurisprudence with the dominant adult-centric legal framework on the mainland. She critiques four recurring analytical missteps in U.S. courts that marginalize children’s interests and highlights Hawaiʻi’s public trust doctrine and cultural values, such as the Aloha Spirit, as models for addressing climate-related harms. …

"Dental Health For Mental Wealth": A Comprehensive Analysis Of The Underexplored Impact Of Oral Health And Behaviors On Neurobiology And Psychological Well-Being, Brooke C. Beck

Mahurin Honors College Capstone Experience/Thesis Projects

This thesis explores the link between oral health and psychological state, specifically, the effect of oral health on psychological state and how appropriate oral health impacts this relationship. A review of the literature was conducted and studies interpreted within the scope of oral health’s impact on psychological health and detailing some of the pathways proposed for such a link. The literature search was limited to the English language from well-known databases mainly from 2015 to 2025. A few outliers are present to include foundational information.

The effects of oral disease and oral self-care behaviors were dissected through a biochemical perspective, …