Digital Commons Network^™

Transient Stress And Childhood Maltreatment: Unraveling Their Impact On Working Memory And Emotion Dysregulation, Serena Veith

Selected Full-Text Dissertations 2020-

Childhood maltreatment is associated with cognitive impairments and emotion dysregulation, with prior research documenting structural changes in stress modulation in affected individuals. This study examined the relationship between childhood maltreatment and working memory (WM), focusing on the roles of stress and emotion dysregulation. While childhood maltreatment has been linked to cognitive deficits, its specific impact on adult WM remains underexplored. It was hypothesized that childhood maltreatment would negatively affect WM. However, initial analyses found no significant relationship between childhood maltreatment and baseline WM. Post-hoc analyses revealed a positive relationship between childhood maltreatment and WM improvement over time, suggesting potential resilience …

Sexual Identity Development In A Culture Of Shame: The Impact Of Non-Affirming Religious Upbringing And Internalized Homophobia On Sexual Satisfaction In Lgbtq Adults, Rhiannon Ashley Gibbs

Selected Full-Text Dissertations 2020-

Internalized homophobia is a common component of the LGBTQ developmental experience which impacts sexual identity development (Peterson & Gerrity, 2006; Rowan & Malcom, 2003). As well, many LGBTQ people raised in Christian religious communities frequently grow up in environments which are not affirming of their sexualities (Barnes & Meyer, 2012; Boppana & Gross, 2019; Herek et al., 2009; Ream & Savin-Williams, 2005; Rodriquez & Oullette, 2000). While much research considers the impact of these minority stressors on LGBTQ well-being (Frost & Meyer, 2009; Herek et al. 2009; Keating & Muller, 2020), fewer consider the specific impact on sexual well- being. …

An Integral Transpersonal Approach To The Self: Practical Maps And Models, Pier Luigi Lattuada

International Journal of Transpersonal Studies Advance Publication Archive

This work aims to focus attention on the concepts of the psyche and of self, and the participatory dialogue between the self and the world, to highlight the contribution that an integral transpersonal psychotherapy (ITP) approach of biotransenergetics (BTE) offers. The ITP approach sees the psyche as the totality of the being and the self as the unifying archetype that defifines it. Some new epistemological maps and concepts are outlined to highlight their usefulness for a clinical and research methodology based on assumptions of a transpersonal and integral order.

Engineering Chimeric Autoantibody Receptor T Cells (Caar): A Potential Cure For Graves' Disease, Kimbal Demars, Abigail Cheever, Chloe Kang, Hunter Lindsay, Mackenzie Hansen, Kim O'Neill, Scott Weber

Library/Life Sciences Undergraduate Poster Competition 2025

• Graves’ Disease (GD) is the 4th most common autoimmune disease in the United States.
• GD is characterized by autoreactive B cells releasing anti-thyroid stimulating hormone receptor (TSHR) Ab that bind to TSHR, causing an overexpression of hormones.
• Excessive hormonal release leads to hyperthyroidism, causing a variety of metabolic issues.
• No cure exists, only limited effectiveness of treatments, including chemotherapy, radiation, or thyroidectomy.
• Chimeric antigen receptors (CAR) T cell therapy has been effective in treating blood cancers.
• Modifying this therapy by engineering T cells that replace the antigen as the T cell receptor will selectively target autoreactive B cells, namely chimeric …

End Epilepsy: Human And Rodent Seizures Demonstrate A Dynamic Interplay With Spreading Depolarizations, Daniel Hummel, Jacob H. Norby, Noah Ricks, John D. Rolston, Shervin Rahimpour, Juha Voipio, Andrew J. Trevelyan, Elliot H. Smith, Ryley Parrish

Library/Life Sciences Undergraduate Poster Competition 2025

Affecting more than 50 million people worldwide, Epilepsy is a condition of repeated seizures. Seizures (Sz) occur when brain cells transmit uncontrolled electrical signals, and most often terminate on their own, but how this happens is unknown. A proposed mechanism of Sz termination is a spreading depolarization (SD). A SD is a wave that travels through the brain, suppressing brain activity. Currently, the relationship between SDs and seizures is not well understood. The goal of this study was to understand how the two phenomena interact in both rodent brains, and humans. Better understanding of SDs may lead to the development …

Enabling Better Interoperability And Reusability For Down Syndrome Transcriptomic Datasets, Harrison Oaks, Garrett L. Wride, Stephen Piccolo

Library/Life Sciences Undergraduate Poster Competition 2025

Introduction: Gene expression profiling has become a cornerstone of biomedical research, offering relevant insights into the molecular mechanisms that underlie complex conditions such as Down syndrome (DS), a condition caused by trisomy 21. RNA expression data from individuals with DS have highlighted critical pathways involved in development, immune function, and disease susceptibility. Despite the availability of over 100 publicly shared RNA expression datasets, their potential remains underutilized due to inconsistent metadata, diverse normalization protocols, and varying data quality. Addressing these barriers is vital to enabling researchers to standardize, integrate, and analyze datasets effectively. We do this by creating a data …

Effects Of Predation On Cognition In Brachyrhaphis Rhabdophora, Elizabeth F. Jenkins, Jerald B. Johnson

Library/Life Sciences Undergraduate Poster Competition 2025

Does predation environment affect the cognitive abilities of the tropical fish Brachyrhaphis rhabdophora?

Effects Of Ethanol On G-Csf Sensitivity In The Ventral Striatum, Kaleb Gardner, Rachel Campbell, Camryn Holt, Zachary Valentine, Chase Seiter, Jordan T. Yorgason

Library/Life Sciences Undergraduate Poster Competition 2025

Granulocyte-colony stimulating factor (G-CSF) is a known neuromodulator for dopamine (DA) release in the ventral striatum • Increased peripheral G-CSF levels enhances abused substance effects • The G-CSF mechanism for enhancing release remains unknown • How ethanol affects G-CSF neuromodulation also remains unknown • The present studies examined G-CSF effects on striatal and mesolimbic circuitry and chronic ethanol effects on this system

Effects Of Acute Injections Of Etoh In Cytokine Release In Mice, Alina Svitlana Rodriguez Bezruchko, Alka Gaur, Carlos M. Moreno, Jordan T. Yorgason, Scott Weber

Library/Life Sciences Undergraduate Poster Competition 2025

To learn the pathway by which the peripheral immune system interacts with dopaminergic neurons and triggers an addiction response, we compared cytokine and chemokine production levels before and after a 20-minute ethanol injection. Since some cytokines and chemokines can cross the blood-brain barrier, their peripheral production may influence neural activity. We had four groups: ethanol, saline, domperidone-ethanol, and domperidone-saline. As domperidone is a dopamine antagonist, we will use it as a control to verify that the change in cytokine production is due to ethanol rather than other factors.

Developement Of A Rodent Virtual Reality System For Measuring Reward, Aman Malhotra, Joe Davis, Jacob Cecil, Lauren Ford, Daniel-Luke Isemonger, Noah Moffat, Ryan Powers, Cody Siciliano, Ryan West, Jordan T. Yorgason

Library/Life Sciences Undergraduate Poster Competition 2025

Rodent VR is a tool for drug impact studies involving VR and optical imaging on motivation-related circuits using customizable maze creation and a comprehensive analysis program. We are using this combined with a GRINS lens surgical implant to gather real time data.

Competitive Bacteria Inhibiting Yersinia Ruckeri Growth – A Strategy To Prevent Enteric Redmouth Disease (Erm) In Freshwater Fish, Kyler Linton, David Erickson

Library/Life Sciences Undergraduate Poster Competition 2025

Pacific freshwater fish are less likely than Atlantic freshwater fish to exhibit Enteric Redmouth Disease (ERM), or Yersiniosis as caused by Yersinia ruckeri. Based on the hypothesis that these fish may harbor commensal bacteria that inhibit Y. ruckeri growth, we isolated many kinds of commensal bacteria from fish intestines that we have collected from Alaska and local streams. Using co-culture experiments, we have conducted competitive assays to determine if the bacteria found in the gut biomes of these fish inhibit the growth of Y. ruckeri. These may be potential probiotic organisms that could provide resistance to ERM disease.

Comparative Whole Genome Sequencing Of Cryopreserved And Ffpe Cancer Tissue, Delaney Anderson, Ken Dixon, Ryan Miller, Sangmoon Lee, Jeffrey Okojie, Jared Barrott

Library/Life Sciences Undergraduate Poster Competition 2025

Whole genome sequencing (WGS) determines the DNA sequence of an organism’s entire genome & plays a key role in cancer precision medicine

• Currently, the main preservation method of cancer tissue for WGS is formalin-fixed, paraffin-embedded (FFPE) tissue; cryopreserved (CP) tissue is not routinely used in clinical settings
• Previous studies have determined CP tissue yields higher quality & quantity of DNA
• This study aimed to compare the outcomes of WGS in CP & FFPE samples.

Chilling Insights: A Comparative Study Of Cancer Tissue Preservation, Rebecca Bascom, Paige Nelson, Jacob Harris, Jack Davis, Mackenzie Burr, Jeffrey Okojie, David Booker, Ken Dixon, Jared Barrott

Library/Life Sciences Undergraduate Poster Competition 2025

It is a fact that personalized cancer treatment leads to better patient outcomes. But what if the current treatments aren't as personalized as they could be?

Clinical cancer tissue samples are typically sent to labs as formalin-fixed and paraffin-embedded (FFPE) tissues. A recent study4 indicates that cryo-preserved (CP) tissues offer significantly better DNA quality and quantity than FFPE samples, suggesting a need to reevaluate preservation methods. We aim to expand this research by comparing protein expression in FFPE and CP samples.

Specifically, we will focus on PD-L1, a protein that inhibits T-cells and is overexpressed in all cancer cells. The …

Barks Vs Bears: A Ruff Reality, Fern Luttrell, Tom Smith, Stephen Herrero, Lana Ciamiello, Hank Hristienko, Erin Jacoway, Linda Wiggins

Library/Life Sciences Undergraduate Poster Competition 2025

• Will your dog protect you from a bear?
• Do dogs provoke bear attacks?
• Is it safe for your dog to be in bear country?

Assessing Sandy Beach Health Throughout The South Atlantic Bight With Ghost Crabs, Raquel Wilson, Blaine D. Griffen

Library/Life Sciences Undergraduate Poster Competition 2025

To better inform the management and protection of marine ecosystems, we examined human impacts on sandy beach health across the South Atlantic Bight by assessing the abundance and size of ghost crab burrows, and habitat quality. We used an urbanization index to measure the level of human impact. Sandy beach ecosystems are ecologically and economically important, yet they face immense pressure from increasing human activity^1,2. Protecting these ecosystems is critical yet challenging due to their large size, but we can evaluate their health and the extent of human impact using a bioindicator species. We used the Atlantic ghost …

Arid1a Knockout: A Catalyst For Osteosarcoma Progression, Alma Taggart, Peyton Worley, Heinen Louis, Emilee Nielson, Jared Barrott

Library/Life Sciences Undergraduate Poster Competition 2025

Osteosarcoma (OS) is a rare form of bone cancer, with high mortality rates in children and young adults. Current OS research has been limited by a lack of mouse models that accurately represent the metastatic and chemoresistant nature of this cancer. Furthermore, by focusing on patient-derived xenograft models it limits the applications of novel immunotherapies because these mouse models lack a competent immune system. By knocking out Arid1a, we generated a mouse model that more accurately reflects the aggressive nature of the tumor with 100% penetrance of tumorigenesis and 41% penetrance of metastasis, while maintaining a competent immune system. This …

Acee And Pflb: Interference In Oxygen Independent Or Dependent Metabolic Pathways Affect Virulence Of P. Carotovorum, Ethan Shreeve, Foxx Naylor, Jeffrey Schachterle

Library/Life Sciences Undergraduate Poster Competition 2025

Pectobacterium carotovorum is a plant-pathogenic bacterium, causing soft rot diseases in vegetables such as potatoes and carrots. Mainly, this is achieved by the production of plant cell walldegrading enzymes, allowing for invasion of host cells. The general mechanisms underlying the pathogenicity of P. carotovorum are well characterized, but the phenotypic effects of some core metabolic processes are not. An important part of metabolism in bacteria is pyruvate production and utilization as a metabolic intermediate. P. carotovorum has two critical genes— pflB and aceE—that play roles in directing pyruvate metabolism. PflB encodes pyruvate formate-lyase, enabling the bacterium to convert pyruvate into …

Where The Green-To-Red Neurexin Grows: Analyzing Neurexin-3a Expressing Neurons Through Dendra2 Knock-Ins And Full Locus Deletion, Dillon J. Brown, Isaac E. Greenwood, Annalie Martin, Arminda Suli Ph.D.

Library/Life Sciences Undergraduate Poster Competition 2025

The optic tectum (OT) is a zebrafish midbrain structure homologous to the mammalian superior colliculus (SC). The OT facilitates integration of multisensory input and coordinates a corresponding involuntary response. Single-cell RNA sequencing data from our lab indicates the differential expression of the presynaptic cell adhesion protein - neurexin3a - within two cell populations (OT5 and OT8) of the zebrafish OT. The SC and neurexin3a have both been implicated in autism spectrum disorder (ASD), warranting, therefore, a further investigation. To visualize neurexin3a positive neurons in the OT, we are generating a transgenic zebrafish line that expresses the green-to-red photoconvertible protein Dendra2 …

Synthesis Of Gold Nanorods As Payloads For Antibody Drug Conjugates For Synovial Sarcoma, Melanie I'Anson-Holton, Andralyn Anmckell, John Hanosek, Jeffrey Okojie, Bridger Kearns, Jared Barrott

Library/Life Sciences Undergraduate Poster Competition 2025

Antibody-drug conjugates (ADC) are burgeoning class of anti-cancer therapies. They rely on the specificity of antibodies to selectively deliver a cytotoxic payload to cancer cells expressing unique antigens. To minimize the toxicity of these ADCs, we designed a multipronged application with two separate components that by themselves are harmless, but when combined result in thermal toxicity to the tumor cells. Gold nanoparticles as the payload was one component and a near IR laser was the other. Gold nanoparticles are innocuous and exhibit localized surface plasmon resonance (LSPR). The LSPR of gold nanoparticles allows them to absorb photons at certain wavelengths, …

Those Dam Fish: Morphological Response In Two Riverine Fish Species Following Dam Construction, Leah Stimpson, Austin Rejcek, Mark C. Belk

Library/Life Sciences Undergraduate Poster Competition 2025

Flow regime is a known predictor of fish shape¹. Conspecific populations living in distinct flow environments often exhibit different morphologies.

Dams present a unique opportunity to observe a dramatically transformed flow regime. Fish populations that once occupied a fast-flowing habitat suddenly live in an artificial reservoir.

The Parana Basin in southern Brazil boasts some of the greatest fish diversity in the world. The biological implications of hydroelectric dam construction along its major rivers must be studied.

Previous literature has been limited to a single species or ecological niche².

➢ Our objective was to describe what morphological …

Rehydration Of Cadaveric Tissue: A Comparative Analysis, Zach Leonard, Emma Anderson, Jason Adams Phd

Library/Life Sciences Undergraduate Poster Competition 2025

Rehydration solutions contain a variety of different chemicals which help keep cadaveric tissue moist and well preserved. Previously, we have identified that ethylene glycol, glycerol, and propylene glycol are all effective humectants that allow cadaveric specimens to retain moisture. Additionally, a mixture of sodium carbonate, ethanol, and formalin, had favorable results in limited study. With this knowledge, we tested and compared the effectiveness of these solutions at rehydrating dried human tissues. In doing this, we have created a tissue library, providing an evidence-based standard for rehydrating solutions to allow for the rehydration of dried specimens in anatomy labs.

Neuroimmune Effects Of Methamphetamine And Ethanol In The Nucleus Accumbens, Brayden Parker, Derek Langford, Channing Syme, Chris Galbraith, Savannah Evans, Matthew Burris, Jordan T. Yorgason

Library/Life Sciences Undergraduate Poster Competition 2025

• Microglia are the innate immune cells of the brain and change morphology with activation, with increased ameoboid morphology with increased immune activation.
• Microglia release and clear reactive oxygen species (ROS)
• ATP is a known chemoattractant to microglia and is released at dopamine terminals in the nucleus accumbens (NAc), which is a reward center of the brain
• Methamphetamine (Meth) is a psychostimulant drug that decreases dopamine clearance and increases ROS

Methamphetamine And Ros Effects On Dopamine And Atp Release, Tyler Love, Jordan T. Yorgason, Taylor Rose, Hillary Wadsworth, Lydia Hawley, Lauren Ford, Sara Linderman, Nathan Sheets

Library/Life Sciences Undergraduate Poster Competition 2025

The Nucleus Accumbens is a reward center of the brain that receives dopamine projections from the Ventral Tegmental Area

Methamphetamine (Meth) is a psychostimulant drug that decreases dopamine clearance and increases Reactive Oxygen Species (ROS)

Meth is known to increase dopamine release in-vivo through ROS

Glucose Oxidase increases ROS

Mechanism Of Copper-Coated Cicnt Inhibition Of Staphylococcus Aureus Biofilm Formation, Emilia Gregory, Lucy Bowden, Bradford Berges

Library/Life Sciences Undergraduate Poster Competition 2025

Staphylococcus aureus is a leading cause of healthcare-associated infections, particularly through biofilm formation on medical devices, leading to severe and recurrent complications¹. The resistance of S. aureus biofilms to traditional antibiotics requires new strategies to mitigate these infections. Our previous findings indicate that the anti-biofilm properties of carbon-infiltrated carbon nanotubes (CICNT) significantly inhibit the growth of S. aureus biofilms². We will further explore if copper, an innately antimicrobial material, will enhance this effect.

To determine the impact that copper would have on bacterial growth, we coated the CICNT with a thin layer of copper and used …

Looking For Manna, Dung, And Craters - Uncovering Hidden Diversity In Circinaria Lichens, Lizzie Perry, Ginny Basset, Steve Leavitt

Library/Life Sciences Undergraduate Poster Competition 2025

• Lichens, symbiotic partnerships between fungi and photosynthetic organisms, are often overlooked in biodiversity studies due to their cryptic nature. The lichen genus, Circinaria —historically, described as “Manna Lichens”, “crater lichens”, “pigeon dung lichens”, and “excrement of the earth”¹ —remains understudied.
• This genus includes approximately 40 formally described species worldwide, however, only 13 have been documented in North America³.
• To better understand species-level diversity of Circinaria in Western North America, we used an integrated data set – DNA, morphology, and ecology – to characterize diversity and delimit potential candidate species.

Laying Framework For A Novel System To Test Effects Of Histone Modifications, Taryn Evans, Luke Ramirez M.S, Aaron Bohn, Jacob Hunter, Sarah Hodson, Sarah Ricks, David Bates Ph.D, Steven M. Johnson Ph.D.

Library/Life Sciences Undergraduate Poster Competition 2025

Chromatin structure and composition play a significant role in regulating gene expression within eukaryotic cells. The fundamental organizational unit of chromatin is the nucleosome, which is composed of ~147 base pairs of DNA wrapped around a histone protein core. Post-translational modifications (PTM’s) to the protruding tails of histone proteins are known to regulate nucleosome occupancy and positioning, which influence chromatin architecture and thus gene expression. However, relatively little is known about the residual effects of histone PTM’s on transcription rate, especially in nucleosomes along the gene body. Here, we demonstrate a method for measuring transcription rate in real-time with a …

I’M Just Like You: Do Sympatric Lizard Species Exhibit Convergent Morphology? (Genus Sceloporus), Abigail Lamartine, Alison Whiting

Library/Life Sciences Undergraduate Poster Competition 2025

The spiny lizards, genus Sceloporus, are the most speciose genus of reptiles endemic to North America. These lizards are commonly seen doing “push-ups” and head bobs, showing off their bright blue belly and throat patches (figure 5).Sceloporus use these displays to attract mates and defend their territory, and the size and color of patches is the most commonly used character to identify species(see figure 3). Within southwestern Utah, there is a small region where two species, S.occidentalis and S. tristichus, overlap in range (figure 1), and lizards can be found that appear to have patches intermediate between the two …

How Does Alcohol Affect Neurotransmission? — An Exploration Of Snap-25, Thomas Weed, Tanner M. Blocker, Jonah R. Beck, Jason T. Carlson, Christopher E. Hunt Jr., Mike Sumsion, Dixon J. Woodbury

Library/Life Sciences Undergraduate Poster Competition 2025

SNAP-25 helps drive fusion of synaptic vesicles with the neuronal membrane. This process of exocytosis is fundamental for any form of neuro-communication. Prior to vesicle fusion, SNAP-25 comes together with two other SNARE proteins, syntaxin and synaptobrevin, to form the SNARE complex. As the SNARE complex tightens, vesicle fusion occurs, leading to neurotransmitter release. SNAP-25 is expressed in two isoforms, SNAP-25A and SNAP-25B, and are expressed at different stages of development. Previous literature has shown that alcohol and oxidative stress directly affect neurotransmission. We sought to determine if the method of action was through altering the secondary structure of SNAP-25. …

Gcsf Involvement In Ethanol Dopamine Adaptations, Zachary Valentine, Chase Seiter, Rachel Campbell, Camryn Holt, Jordan T. Yorgason

Library/Life Sciences Undergraduate Poster Competition 2025

Objective: Investigate the role of Granulocyte-colony stimulating factor (GCSF) in ethanol-induced dopamine adaptations using fast-scan cyclic voltammetry.

Hypothesis: Prolonged alcohol exposure will weaken GCSF release, resulting in diminished effects on dopamine terminals.

Dopamine (DA) release in the nucleus accumbens (NAc) from the ventral tegmental area (VTA) plays a crucial role in learning stimuli associated with reward

Granulocyte-colony stimulating factor (GCSF) is a known neuromodulator for for DA release

Ethanol has been demonstrated to increase the firing rate of dopamine neurons in the (VTA)

The effects of ethanol on GCSF neuromodulation remains unknown

Frog Barcodes: Scanning The Secret Species Of Pelodryadinae, Kennedy Hunter, Taylor Probst, Alison Whiting

Library/Life Sciences Undergraduate Poster Competition 2025

Tree frogs (Hylidae) have unique adaptations such as toe pads for life in the trees (figure 1).

The subfamily Pelodryadinae is poorly known and primarily found in the Australopapuan region.

Papua New Guinea is the island with the greatest frog diversity but many species remain undescribed.

DNA barcoding has been shown to be an effective tool in species delimitation and for examining species diversity in poorly understood groups.