Digital Commons Network^™

Mga-Related Syndrome: A Proposed Novel Disorder, Bobbi Mcgivern, Michelle M Morrow, Erin Torti, Kirsty Mcwalter, Ingrid M Wentzensen, Kristin G Monaghan, Amanda Gerard, Laurie Robak, David Chitayat, Claire Botsford, Sarah Jurgensmeyer, Peter Leahy, Paul Kruszka

Faculty, Staff and Students Publications

MGA (OMIM: 616061) encodes a dual-specificity transcription factor that regulates the expression of Max-network and T-box family target genes, important in embryogenesis. Previous studies have linked MGA to various phenotypes, including neurodevelopmental disorders, congenital heart disease, and early-onset Parkinson's disease. Here, we describe the clinical phenotype of individuals with de novo, heterozygous predicted loss-of-function variants in MGA, suggesting a unique disorder involving both neurodevelopmental and congenital anomalies. In addition to developmental delays, certain congenital anomalies were present in all individuals in this cohort including cardiac anomalies, male genital malformations, and craniofacial dysmorphisms. Additional findings seen in multiple individuals in this …

Building Toward Population Reserve And A Critical Positive Psychiatry, Peter J. Whitehouse

Faculty Scholarship

No abstract provided.

Utah Producers And Soil Health: Statewide Survey Results, Peggy Petrzelka, Jessica Ulrich-Schad, Matt Yost, Jenae Dean, Earl Creech, Linda Schott, Tony Richards, Kristy Davis

All Current Publications

To gain soil health perspectives and actions from a representative sample of Utah farmers and ranchers, a mail and online survey of Utah producers was conducted in 2024, focused on those who indicated they produced crops in 2023. In this report, we provide an overview of the survey results, with a specific focus on producers’ views on soil health, indicators used for soil health, factors that influence soil health adoption, and information sources used for soil health.

Intervention Strategies To Prevent Mental Health Problems And Improve Resilience In Employed Parents From Conception Until The Child Is 5 Years Of Age: A Scoping Review, Neeltje Crombag, Bieke Bollen, Eline Vancoppenolle, Thomas Vandendriessche, Dagmar Versmissen, Martha Paisi, Jill Shawe, Susan Garthus-Niegel, Annick Bogaerts

School of Nursing and Midwifery

Aim: To understand the extent and type of evidence in relation to the effectiveness of intervention strategies targeting working pregnant women, and their partners, for the prevention of mental health problems (depression, anxiety) and improving resilience, from conception until the child is 5 years of age. Methods: A scoping review was conducted searching Pubmed (including Medline), Embase, Web of Science Core Collection and Scopus. Inclusion criteria were based on population (employed parents), context (from -9 months to 5 years postpartum) and concept (mental health problems, resilience and prevention/ preventative interventions). Results: Of the 17,699 papers screened, 3 full text papers …

Molecular Logic For Cellular Specializations That Initiate The Auditory Parallel Processing Pathways, Junzhan Jing, Ming Hu, Tenzin Ngodup, Qianqian Ma, Shu-Ning Natalie Lau, M Cecilia Ljungberg, Matthew J Mcginley, Laurence O Trussell, Xiaolong Jiang

Faculty, Staff and Students Publications

The cochlear nuclear complex (CN), the starting point for all central auditory processing, encompasses a suite of neuronal cell types highly specialized for neural coding of acoustic signals. However, the molecular logic governing these specializations remains unknown. By combining single-nucleus RNA sequencing and Patch-seq analysis, we reveal a set of transcriptionally distinct cell populations encompassing all previously observed types and discover multiple hitherto unknown subtypes with anatomical and physiological identity. The resulting comprehensive cell-type taxonomy reconciles anatomical position, morphological, physiological, and molecular criteria, enabling the determination of the molecular basis of the specialized cellular phenotypes in the CN. In particular, …

Bone Marrow Transplantation Reverses Metabolic Alterations In Multiple Sulfatase Deficiency: A Case Series, Nishitha R Pillai, Ning Liu, Xiyuan Li, Xiqi Li, Rebecca Ahrens-Nicklas, Laura Adang, Julie B Eisengart, Grace Bronken, Ashish Gupta, Troy C Lund, Chester B Whitley, Sarah H Elsea, Paul J Orchard

Faculty, Staff and Students Publications

BACKGROUND: Multiple sulfatase deficiency (MSD) is an exceptionally rare neurodegenerative disorder due to the absence or deficiency of 17 known cellular sulfatases. The activation of all these cellular sulfatases is dependent on the presence of the formylglycine-generating enzyme, which is encoded by the SUMF1 gene. Disease-causing homozygous or compound heterozygous variants in SUMF1 result in MSD. Other than symptomatic treatment, no curative therapy exists as of yet for MSD. Eight out of these 17 sulfatases are primarily localized in the lysosome.

METHODS: Two siblings with attenuated MSD underwent hematopoietic cell transplantation (HCT), evaluating the possibility of lysosomal enzymatic cross-correction from …

Synthesis Of Cultural Responsive Learning: A Critical Analysis Of Culture, Learning, And Professional Practice, Alex Bishop

MAGIS: Student Development Journal

This piece is a reflective invitation, welcoming a curious mind in understanding culture and the imperative approach of cultural responsiveness in learning spaces. Through a critical analysis, this piece explores the knowledge gain and learning of culture, including the dynamic and fluid nature that align with each student as they navigate various educational and environmental spaces. Critical frameworks are outlined to enhance the importance of how culture systematically and socially unfolds. Finally, this paper provides tools of opportunity that can be utilized for the continued demonstration of a culturally responsive practice.

Militarized Sexual Labor: Violent Encounters Between Comfort Women And Japanese Soldiers, And Camptown Women And American Soldiers, Shoyun Claire Oh

Historical Perspectives: Santa Clara University Undergraduate Journal of History, Series II

No abstract provided.

Prostitutes, Power, And Policy: Reevaluating The Origins Of The Chinese Exclusion Act, Rosemary Huang

Historical Perspectives: Santa Clara University Undergraduate Journal of History, Series II

No abstract provided.

Remodeling Pedagogical Evaluation Tools To Incorporate Student Self-Efficacy And Sense Of Belonging In Scientific Research, Richelle L. Tanner, Nicholas P. Burnett, Emily E. King, Anne E. Todgham

Biology, Chemistry, and Environmental Sciences Faculty Articles and Research

Curated undergraduate research experiences have been widely used at colleges and universities for decades to build student interest, technical preparation, and confidence in the pursuit of scientific careers. Educators often employ standardized survey instruments to evaluate learning outcomes for research experiences, but many of these assessments consider only technical skill development and career interests and are not rooted in discrete pedagogical theories. As higher education aims to create inclusive and equitable learning experiences for students, we argue that pedagogical assessment tools for undergraduate research experiences need to expand to consider outcomes such as increased science literacy, confidence in relational “soft” …

The Role Of Neurofilament Light (Nfl) And Glial Fibrillary Acidic Protein (Gfap) In Ms And Aqp4-Nmosd: Advancing Clinical Applications., Sara Samadzadeh, Roy D. Sleator

Department of Biological Sciences Publications

Fluid biomarkers such as Glial Fibrillary Acidic Protein (GFAP) and Neurofilament Light (NfL) play important roles in the diagnosis, monitoring, and evaluation of therapeutic responses in conditions such as Multiple Sclerosis (MS) and Aquaporin-4 Neuromyelitis Optica Spectrum Disorder (AQP4-NMOSD). These biomarkers offer key insights into the underlying pathophysiological mechanisms of these diseases, enabling effective follow-up and personalized treatment approaches, which are essential for improving patient outcomes. Herein, we synthesize the structural attributes, functional roles, and clinical significance of GFAP and NfL in the context of MS and AQP4-NMOSD. We explore the critical implications of these biomarkers in disease manifestation and …

Factors Associated With Parental Substance Use And Child Welfare In Nevada 2019-2021, Lisa Christine Lee

Walden Dissertations and Doctoral Studies

Substance use is a growing public health concern that is adversely impacting reproductive-aged individuals and families (Bruzelius & Martins, 2022). Parental substance use is increasingly driving family separation through the child welfare system. Substance use and family separation intersect with trauma and adverse childhood experiences in a variety of ways. Risk factors and race/ethnicity may contribute to family surveillance, bias, and disproportionality in child welfare and impact reunification and cause further trauma. This study explored associations between household characteristics and risk factors and services provided to families with reunification goals for families with child welfare involvement due to substance use …

Factors Associated With Parental Substance Use And Child Welfare In Nevada 2019-2021, Lisa Christine Lee

Walden Dissertations and Doctoral Studies

Substance use is a growing public health concern that is adversely impacting reproductive-aged individuals and families (Bruzelius & Martins, 2022). Parental substance use is increasingly driving family separation through the child welfare system. Substance use and family separation intersect with trauma and adverse childhood experiences in a variety of ways. Risk factors and race/ethnicity may contribute to family surveillance, bias, and disproportionality in child welfare and impact reunification and cause further trauma. This study explored associations between household characteristics and risk factors and services provided to families with reunification goals for families with child welfare involvement due to substance use …

Effects Of Sex, Mating Status, And Genetic Background On Circadian Behavior In Drosophila, Oghenerukevwe Akpoghiran, Alexandra K. Strich, Kyunghee Koh

Farber Institute for Neuroscience Faculty Papers

Circadian rhythms play a crucial role in regulating behavior, physiology, and health. Sexual dimorphism, a widespread phenomenon across species, influences circadian behaviors. Additionally, post-mating physiological changes in females are known to modulate various behaviors, yet their effects on circadian rhythms remain underexplored. Here, using Drosophila melanogaster, a powerful model for studying circadian mechanisms, we systematically assessed the impact of sex and mating status on circadian behavior. We measured circadian period length and rhythm strength in virgin and mated males and females, including females mated to males lacking Sex Peptide (SP), a key mediator of post-mating changes. Across four wild-type and …

Mental Rotation: Psychometric Analysis Of The Online Purdue Spatial Visualization Test: Rotations And Relationships Between Mental Rotation Skill And Engineering Undergraduate Success, Savanna Dautle

Theses and Dissertations

“Literature shows that spatial skills, and in particular, mental rotation skills, are predictors of success in STEM. Students who have strong spatial visualization skills are more likely to demonstrate better academic performance and higher graduation rates in STEM. Several instruments are used to measure mental rotation skills, most of which are paper-based… To measure the range of skills typically seen in undergraduate engineering students, the PSVT:R has been historically preferred for its use of a variety of 3-dimensional shapes, which are appropriately challenging to visualize, and for its established reliability and validity [using classical test theory]. An [online] version of …

Emotional Intelligence And Socioemotional Attributes: Distinct Constructs And Their Uses, John D. Mayer, David R. Caruso

UNH Personality Lab

We examine evidence for the validity of different measures under the label emotional intelligence (EI). Some measures are valid for the assessment of EI and others are valid for the assessment of socioemotional attributes (SEA). The constructs of EI and SEA are defined and measures of each described, along with the mental response processes the measures elicit: test-takers’ abilities, self-estimated attributes, or observer reports. Both EI and SEA measures are valid but for distinctly different purposes, and the two classes of measures make different predictions. We add our voices to those who have advocated for dropping the EI label from …

Evaluating Elk Distribution And Conflict Under Proposed Management Alternatives At The National Elk Refuge In Jackson, Wyoming, Gavin G. Cotterill, Paul C. Cross, Eric K. Cole, Jonathan D. Cook, Margaret C. Mceachran, Tabitha A. Graves

Aspen Bibliography

We evaluated measurable attributes describing the current and future distribution of Cervus elaphus canadensis (elk) across a region surrounding Jackson, Wyoming, for five feedground management alternatives proposed by the U.S. Fish and Wildlife Service as a revision to 2007 "Bison and Elk Management Plan" of the National Elk Refuge. A resource selection function evaluated measurable attributes of interest to managers, including elk use of private property and sensitive habitat types at monthly timesteps and varying winter conditions. The study area boundaries were created through an expert elicitation process and consist of the Jackson Elk Herd Unit, Grand Teton National Park, …

Using Phylogenetics And Floral Evolution Of Sicklebill Hummingbird-Pollinated Centropogon Subgenus Centropogon To Support Undergraduate Research, Janet Mansaray

LSU Doctoral Dissertations

The genus Centropogon subgenus Centropogon, offers an ideal system for studying macroevolutionary patterns due to its diverse floral morphologies and specialized pollinator interactions. This subgenus comprises 55 species, mostly found in mid-elevation Andean forests, where many species exhibit abruptly curved flowers, often associated with pollination by sicklebill hummingbirds. Using phylogenomic approaches, we conducted the first densely sampled analysis of this group, confirming the monophyly of two sections. Our study highlighted extensive gene tree discordance, likely driven by incomplete lineage sorting. Floral curvature and inflorescence structure evolved in a correlated fashion, leading to multiple independent losses of traits linked to …

Measures Of Joint Kinematic Reliability During Repeated Softball Pitching, Erin Pletcher, Mita Lovalakar, Takashi Nagai, Chris Connaboy

Department of Exercise Science Faculty Papers

Background/Objectives: Three-dimensional motion analysis is often used to evaluate improvements or decrements in movement patterns in athletes. The purpose of this study was to evaluate the reliability of joint flexion/extension angles of the pitching elbow and bilateral knees and hips in softball pitchers. Methods: Fourteen softball pitchers (17.9 ± 2.3 years) were tested in one session consisting of four sets of five consecutive fastballs and a second session of two sets of five fastballs. The magnitude of systematic bias and within-subject variation was calculated between pitches. An iterative intraclass correlation coefficient (ICC) process was used to determine intra- and inter-session …

[Excerpt From] Transforming Nursing Education: Infusing Gender-Sensitive Care Into Healthcare, Christine Rodriguez

Sigma Publications: Book Excerpts

Trans and gender-diverse patients face significant barriers to respectful, comprehensive healthcare. Provider ignorance shouldn't be one of them. TRANSforming Nursing Education supplies the context to help readers understand the gaps and missteps in providing healthcare to this marginalized population and explains how we can better treat these patients.

Author Christine Rodriguez tackles tough subjects and tough statistics head on. This no-nonsense guide is packed with inclusive case studies, immersive simulation-based scenarios, checklists, and ready-to-use templates on everything from social transitioning to hormone therapy to surgeries and potential complications, all with thoughtful, reflective questions to guide readers in their understanding of …

Carano V. Disney: The First Amendment Right Of Expressive Association As A Defense To Firing Employees For Their Political Speech, Joel Timmer

Washington Journal of Law, Technology & Arts

Following a series of controversial social media posts by actress Gina Carano, a cast member of the Disney+ Star Wars series, The Mandalorian, Disney terminated her employment on the show and announced that Carano would not appear in any future Star Wars projects. According to Disney, Carano was terminated because the views expressed in her posts did not align with the company’s values. Carano filed suit against Disney, claiming Disney violated California state labor laws that generally prohibit employers from sanctioning employees for their political activities. In response, Disney claims that the First Amendment right of expressive association provides …

Enhancing In Vitro Digestibility And Volatile Profile Of Sorghum Proteins Using Supercritical Carbon Dioxide Drying, Nafisa Sadaf, Arda Tuhanioglu, Safoura Ahmadzadeh, Ali Ubeyitogullari

Food Science Faculty Publications and Presentations

The goal of this research was to use supercritical carbon dioxide (SC-CO2) drying as a novel approach to generate sorghum protein concentrates with enhanced functional characteristics. Sorghum protein concentrates were extracted from white whole-grain sorghum flour and dried in two ways: freeze-drying and SC-CO2 drying. The dried proteins were characterized for their volatile compound content, in vitro digestibility, and amino acid composition. A more porous structure was observed for the SC-CO2-dried sorghum proteins compared with their freeze-dried counterparts. In the SC-CO2-dried samples, the levels of alcohols, esters, and organic acids were significantly lower than those in the freeze-dried ones, whereas …

"Our Blood Is Not Cheap": A Photovoice Project On Being Arab In A Racialized United States, Leticia Villarreal Sosa, Suhad Tabahi, Itedal Shalabi

School of Social Work Faculty Publications

The Arab American community has faced a history of racialization dating back to the late 19th century. The events of 9/11 and the heightened rhetoric of hate during the Trump presidency encouraged anti-Muslim sentiment and increased racial profiling and harassment. This community-based participatory research (CBPR) project uses Photovoice as a methodology to better understand the lived experiences and narratives of Arab Americans in the post-Trump1 era and as a tool for advocacy. The findings from the photo sharing sessions underscore the continued challenge of identity and representation, (in)visibility, and pushing back against anti-Arab/Muslim racism. The findings also highlight religion as …

Exploring The Role Of Brain Angiogenesis Inhibitor 3 (Bai3) In Regulating Body Weight, Haifa Alsahrif

All ETDs from UAB

Obesity is a significant public health issue, strongly associated with various metabolic disorders, including type 2 diabetes and cardiovascular disease. Understanding the mechanisms that contribute to obesity is essential for developing effective interventions. One critical area of interest involves G-protein-coupled receptors (GPCRs), which are important in regulating metabolic health. These receptors are known to be involved in critical metabolic functions such as insulin secretion, lipid metabolism, and glucose uptake. The role of the GPCR, brain angiogenesis inhibitor-3 (BAI3), in metabolic regulation has not been fully explored. This dissertation focuses on the known functions of the BAI isoforms (BAI1-3) and presents …

Mergers And Acquisitions (M&As) In Pharmaceutical Markets: Associations With Market Concentration, Prices, Drug Quantity Sold, And Shortages, J. Daniel Mcgeeney M.S., Aylin Sertkaya Ph.D., Leah Ross M.A., Fred Ledley M.D., Cody Hyman Ph.D.

CISI Publication

In recent decades, the pharmaceutical industry has become increasingly concentrated in the United States, in part due to mergers and acquisitions (M&As) between drug manufacturers. This consolidation from M&As has been cited as a key factor affecting drug prices and drug shortages (U.S. Federal Trade Commission, 2022). In this study, we assessed trends in pharmaceutical M&As during 2010–2023 and evaluated the characteristics of drugs and companies involved in those M&As. We considered the effects of M&As on market concentration, drug prices, drug quantity sold, and drug shortages. We also considered how these associations vary by drug characteristics, including brand drugs …

Society For Immunotherapy Of Cancer: Updates And Best Practices For Multiplex Immunohistochemistry (Ihc) And Immunofluorescence (If) Image Analysis And Data Sharing, Janis M Taube, Joel C Sunshine, Michael Angelo, Guray Akturk, Margaret Eminizer, Logan L Engle, Cláudia S Ferreira, Sacha Gnjatic, Benjamin Green, Shirley Greenbaum, Noah F Greenwald, Cyrus V Hedvat, Travis J Hollmann, Daniel Jiménez-Sánchez, Konstanty Korski, Ana Lako, Edwin R Parra, Marlon C Rebelatto, David L Rimm, Scott J Rodig, Jamie Rodriguez-Canales, Jeffrey S Roskes, Kurt A Schalper, Emanuel Schenck, Keith E Steele, Michael J Surace, Alexander S Szalay, Michael T Tetzlaff, Ignacio I Wistuba, Jennifer H Yearley, Carlo B Bifulco

Faculty, Staff and Student Publications

Objectives: Multiplex immunohistochemistry and immunofluorescence (mIHC/IF) are emerging technologies that can be used to help define complex immunophenotypes in tissue, quantify immune cell subsets, and assess the spatial arrangement of marker expression. mIHC/IF assays require concerted efforts to optimize and validate the multiplex staining protocols prior to their application on slides. The best practice guidelines for staining and validation of mIHC/IF assays across platforms were previously published by this task force. The current effort represents a complementary manuscript for mIHC/IF analysis focused on the associated image analysis and data management.

Methods: The Society for Immunotherapy of Cancer convened a task …

Gene Signatures Derived From Transcriptomic-Causal Networks Stratify Colorectal Cancer Patients For Effective Targeted Therapy, Akram Yazdani, Heinz-Josef Lenz, Gianluigi Pillonetto, Raul Mendez-Giraldez, Azam Yazdani, Hanna Sanoff, Reza Hadi, Esmat Samiei, Alan P Venook, Mark J Ratain, Naim Rashid, Benjamin G Vincent, Xueping Qu, Yujia Wen, Michael Kosorok, William F Symmans, John Paul Y C Shen, Michael S Lee, Scott Kopetz, Andrew B Nixon, Monica M Bertagnolli, Charles M Perou, Federico Innocenti

Faculty, Staff and Student Publications

Background: Gene signatures derived from transcriptomic-causal networks offer potential for tailoring clinical care in cancer treatment by identifying predictive and prognostic biomarkers. This study aimed to uncover such signatures in metastatic colorectal cancer (CRC) patients to aid treatment decisions.

Methods: We constructed transcriptomic-causal networks and integrated gene interconnectivity into overall survival (OS) analysis to control for confounding genes. This integrative approach involved germline genotype and tumor RNA-seq data from 1165 metastatic CRC patients. The patients were enrolled in a randomized clinical trial receiving either cetuximab or bevacizumab in combination with chemotherapy. An external cohort of paired CRC normal and tumor …

Patient-Derived Xenografts Of Triple-Negative Breast Cancer Enable Deconvolution And Prediction Of Chemotherapy Responses, Jonathan T Lei, Lacey E Dobrolecki, Chen Huang, Ramakrishnan R Srinivasan, Suhas V Vasaikar, Alaina N Lewis, Christina Sallas, Na Zhao, Jin Cao, John D Landua, Chang In Moon, Yuxing Liao, Susan G Hilsenbeck, C Kent Osborne, Mothaffar F Rimawi, Matthew J Ellis, Varduhi Petrosyan, Bo Wen, Kai Li, Alexander B Saltzman, Antrix Jain, Anna Malovannaya, Gerburg M Wulf, Elisabetta Marangoni, Shunqiang Li, Daniel C Kraushaar, Tao Wang, Senthil Damodaran, Xiaofeng Zheng, Funda Meric-Bernstam, Gloria V Echeverria, Meenakshi Anurag, Xi Chen, Bryan E Welm, Alana L Welm, Bing Zhang, Michael T Lewis

Faculty, Staff and Students Publications

Combination chemotherapy remains essential for clinical management of triple-negative breast cancer (TNBC). Consequently, responses to multiple single agents cannot be delineated at the single patient level, even though some patients might not require all drugs in the combination. Herein, we conduct multi-omic analyses of orthotopic TNBC patient-derived xenografts (PDXs) treated with single agent carboplatin, docetaxel, or the combination. Combination responses were usually no better than the best single agent, with enhanced response in only ~13% of PDX, and apparent antagonism in a comparable percentage. Single-omic comparisons showed largely non-overlapping results between genes associated with single agent and combination treatments that …

A Sequencing Overview Of Malignant Peripheral Nerve Sheath Tumors: Findings And Implications For Treatment, Kangwen Xiao, Kuangying Yang, Angela C Hirbe

2020-Current year OA Pubs

Malignant peripheral nerve sheath tumors (MPNSTs) are rare but aggressive malignancies with a low 5-year survival rate despite current treatments. MPNSTs frequently harbor mutations in key genes such as

Leveraging A New Data Resource To Define The Response Of Cryptococcus Neoformans To Environmental Signals, Yu Sung Kang, Jeffery Jung, Holly L Brown, Chase Mateusiak, Tamara L Doering, Michael R Brent

2020-Current year OA Pubs

Cryptococcus neoformans is an opportunistic fungal pathogen with a polysaccharide capsule that becomes greatly enlarged in the mammalian host and during in vitro growth under host-like conditions. To understand how individual environmental signals affect capsule size and gene expression, we grew cells in all combinations of 5 signals implicated in capsule size and systematically measured cell and capsule sizes. We also sampled these cultures over time and performed RNA-seq in quadruplicate, yielding 881 RNA-seq samples. Analysis of the resulting data sets showed that capsule induction in tissue culture medium, typically used to represent host-like conditions, requires the presence of either …