Digital Commons Network^™

News And Notices, Continental Birdlife

Continental Birdlife

No abstract provided.

Answer To Snap Judgment 5, Wayne Hoffman

Continental Birdlife

No abstract provided.

Full Issue, Continental Birdlife

Continental Birdlife

No abstract provided.

Book Reviews, Elaine Cook

Continental Birdlife

No abstract provided.

Recent Literature, Continental Birdlife

Continental Birdlife

No abstract provided.

Recent Literature, Continental Birdlife

Continental Birdlife

No abstract provided.

Morphological And Scanning Electron Microscopy Characterization Of A Spirurid In A Wild Sunda Pangolin (Manis Javanica), Punnarat Vibulchan, Chong Shin Min, Chiharu Okumura, Piyanan Taweethavonsawat

The Thai Journal of Veterinary Medicine

This study identifies and characterizes a spirurid in a wild Sunda pangolin (Manis javanica) using scanning electron microscopy (SEM). Native to Southeast Asia, the Sunda pangolin faces critical threats from poaching, illegal trafficking for its scales and meat, habitat loss, urban conflicts, and disease. Despite this, little is known about the biology of wild Sunda pangolins. In this research, spirurid parasites were recovered from a pangolin fatally injured in a vehicular collision. The parasites were preserved and analyzed with SEM, revealing key morphological features such as papillae, lip-like structures, and an anal opening in females. This study enhances …

Charting A New Vision: Lessons On Vision & Change From A Network Of Biology Educators, Jeremy L. Hsu, Anjali Misra, Michael J. Wolyniak, Carlos C. Goller, Stephanie Mathews, Uma Swamy, Dina L. Newman, Michael E. Moore

Biology, Chemistry, and Environmental Sciences Faculty Articles and Research

The 2011 Vision & Change report outlined several recommendations for transforming undergraduate biology education, sparking multiple pedagogical reform efforts. Among these was the Promoting Active Learning and Mentoring (PALM) network, an NSF-funded program that provided mentorship and training to instructors on implementing active learning in the classroom. Here, we provide a perspective on how members of the biology education community in PALM view the recommendations of Vision & Change, drawing upon our experiences both as members of PALM and as leaders of an associated project funded by another NSF grant that hosted PALM alumni at various conferences. These efforts …

Exploring The Impact Of Biological Sex On Intrinsic Connectivity Networks In Ptsd: A Data-Driven Approach., Andrew A Nicholson, Jonathan M Lieberman, Niki Hosseini-Kamkar, Kristen Eckstrand, Daniela Rabellino, Breanne Kearney, David Steyrl, Sandhya Narikuzhy, Maria Densmore, Jean Théberge, Fardous Hosseiny, Ruth A Lanius

Medical Biophysics Publications

INTRODUCTION: Sex as a biological variable (SABV) may help to account for the differential development and expression of post-traumatic stress disorder (PTSD) symptoms among trauma-exposed males and females. Here, we investigate the impact of SABV on PTSD-related neural alterations in resting-state functional connectivity (rsFC) within three core intrinsic connectivity networks (ICNs): the salience network (SN), central executive network (CEN), and default mode network (DMN).

METHODS: Using an independent component analysis (ICA), we compared rsFC of the SN, CEN, and DMN between males and females, with and without PTSD (n = 47 females with PTSD, n = 34 males with PTSD, …

High Hopes: Legal And Ethical Issues With Post-Trial Access To Psychedelic Drugs, Callie Terris, Emma Tumilty

Journal of Health Care Law and Policy

No abstract provided.

Perceptions Of Law Enforcement Spouses Regarding Officer Safety And Danger, Heidi Marie Rose

Walden Dissertations and Doctoral Studies

Policing is a stressful and dangerous occupation that is imperative to a functioning society, and stress should be limited to ensure a healthy mind and body. The purpose of this study was to examine the perceptions of law enforcement spouses regarding officer safety and danger, which was lacking in the research. Law enforcement spouses have a significant impact over the stress levels of their loved ones. The work–life balance and work–family conflict theories were the theoretical framework used to relate to the study and support the research. The generic qualitative design was used with semistructured interviews to gather research data …

Perceptions Of Law Enforcement Spouses Regarding Officer Safety And Danger, Heidi Marie Rose

Walden Dissertations and Doctoral Studies

Policing is a stressful and dangerous occupation that is imperative to a functioning society, and stress should be limited to ensure a healthy mind and body. The purpose of this study was to examine the perceptions of law enforcement spouses regarding officer safety and danger, which was lacking in the research. Law enforcement spouses have a significant impact over the stress levels of their loved ones. The work–life balance and work–family conflict theories were the theoretical framework used to relate to the study and support the research. The generic qualitative design was used with semistructured interviews to gather research data …

"It's Definitely New And Different...It's Really Engaging": Understanding The Power Of Storytelling Towards Secure Password Creation, Rizu Paudel, Mahdi Nasrullah Al-Ameen

Computer Science Student Research

There is a dearth in existing literature to attain systematic understanding of leveraging digital storytelling in security designs. As we begin to address this gap, we focused on user authentication where the existing password composition policies and password meters often fail to help users around creating a strong and memorable password. To this end, we conducted a lab study with 19 participants, where we updated our initial designs in an iterative manner based on their feedback. We then conducted a between-subject online study with 104 participants over Amazon Mechanical Turk to evaluate our designs. We found that all of our …

Spin Caloritronics As A Probe Of Nonunitary Superconductors, Taiki Matsushita, Takeshi Mizushima, Yusuke Masaki, Satoshi Fujimoto, Ilya Vekhter

Faculty Publications

Superconducting spintronics explores the interplay between superconductivity and magnetism, sparking substantial interest in nonunitary superconductors as a platform for magneto-superconducting phenomena. However, identifying nonunitary superconductors remains challenging. We demonstrate that spin current driven by thermal gradients sensitively probes the nature of the condensate in nonunitary superconductors. Spin polarization of the condensate in momentum space induces the superconducting spin Seebeck effect, where a spin current is generated along thermal gradients without a thermoelectric charge current. Notably, the nonvanishing superconducting spin Seebeck effect provides a smoking gun evidence of nonunitary superconductivity because it reflects the spin polarization of the condensate in momentum …

A Stewardship Of Land And Creatures, Jeremy Hummel

Faculty Work Comprehensive List

"A fuller, richer vision of agriculture is no less than one that supplies varied types of services for humans while also ministering to the need for creation to praise its Creator through its own being."

Posting about the calling of agriculture from In All Things, an online hub that offers insight into maintaining and faithful and orthodox Reformed Christian worldview while fearlessly engaging in every aspect of contemporary life – until all is made new.

A Stewardship of Land and Creatures

Securing A Virtual Reality Classroom Using Unity, Okemute Samuel Idonor

Theses and Dissertations

This study examines how security features might be incorporated into a Unity created virtual reality (VR) classroom, with a particular emphasis on important concerns including user privacy, data security, and illegal access. The increasing usage of virtual reality (VR) technology in educational settings has made it crucial to ensure the security of these immersive systems, especially when it comes to safeguarding sensitive user data. Designing and implementing a secure VR classroom prototype that could successfully protect against common security concerns, such as unauthorized access and data breaches, was the main goal of this project. Multi-Factor Authentication (MFA), Role-Based Access Control …

Effect Of Resin Restorative Material Type And Layering Techniques On The Fracture Resistance Of Maxillary Premolars, Mohamed Fouad Haridy, Radwa Ahmed Nagy, Shimaa El-Sayed El-Husseiny

Dentistry

No abstract provided.

Heavy Metals Pollution In Roadside Ecosystems, Lilian Matafu

Tanzania Journal of Engineering and Technology (TJET)

Heavy metals refer to metallic elements that are characterized by having a relatively high density and they are toxic or poisonous even at low concentration. They are environmental pollutant owing to toxicity and longevity in atmosphere and ability to accumulate in living things via bioaccumulation. They tend to enter in different system such as food chain. Analyses of water, soil sediment and the surrounding growing plants (Cynodon dactylon and Cyperus species) for selected heavy metals (Cd, Pb, Zn and Cu) were conducted on a roadside pond located at Boko MSB, Dar es Salaam. Pond water, soil sediments and plant samples …

Guarding Against Informants In Wrongful Conviction Cases. “The Trust Of The Innocent Is The Liar’S Most Useful Tool.”, Marc Consalo

The University of New Hampshire Law Review

By some estimates, tens of thousands of individuals are currently wrongfully convicted and serving time in the United States’ prison system for crimes they did not commit. Further concerning is that one of the most common reasons for these unjust outcomes rests with the use of jailhouse informants who often lie in exchange for time off their own sentences. While many other reasons exist for this epidemic, curtailing corrupt jailhouse snitches in order to reduce the harm they commit against innocent citizens is within our grasp. This Article purports to offer several solutions to reduce and in some cases eliminate …

Residual Traditional Risk In Non-Traditional Atherosclerotic Diseases, Federico Biscetti, Giorgia Polito, Maria Margherita Rando, Maria Anna Nicolazzi, Luis H. Eraso, Paul J. Dimuzio, Massimo Massetti, Antonio Gasbarrini, Andrea Flex

Department of Surgery Faculty Papers

Individuals with chronic inflammatory and immune disorders are at an increased risk of atherosclerotic events and premature cardiovascular (CV) disease. Despite extensive literature exploring the relationship between "non-traditional" atherosclerotic conditions and CV risk, many aspects remain unresolved, including the underlying mechanisms promoting the "non-traditional CV risk", the development of an innovative and comprehensive CV risk assessment tool, and recommendations for tailored interventions. This review aims to evaluate the available evidence on key "non-traditional" CV risk-enhancer conditions, with a focus on assessing and managing CV risk factors. We conducted a comprehensive review of 412 original articles, narrative and systematic reviews, and …

Mathematics In Everyday Life: Exploring Practical Applications And Real-World Impact, Priyant Banerjee, Arshad Bhat

Himalayan Research Papers Archive

Mathematics is an essential part of daily life and influences decisions and problem-solving in various aspects of life. This study explores how mathematical concepts are embedded in daily activities such as financial management, cooking, travel planning, and technological interactions. We will show how arithmetic, algebra, geometry, and statistics are applied in real life to improve decision-making, efficiency, and productivity. Findings indicate that people with higher mathematical literacy solve problems more efficiently, especially in budgeting, as accurate calculations minimize financial mistakes and facilitate long-term financial planning. In cooking, proportional reasoning ensures the accuracy of recipes, thus providing consistent culinary results. Travel …

Between Pedagogical Content Knowledge And Confidence: A Case Study Of Pronunciation Training And Teacher Preparation, Lena Barrantes-Elizondo, Joshua Gordon

Faculty Publications

While many teachers do not feel confident teaching pronunciation because of limited preparation in different areas, research has demonstrated positive effects of training in pronunciation pedagogy, as teachers who receive such training develop cognitions (i.e., knowledge, beliefs, thoughts, actions) that align with current tenets of pronunciation pedagogy. Drawing on this assertion, this paper reports the results of a qualitative case study with five pre-service teaching-English-to-speakers-of-other-languages (TESOL) teachers enrolled in a pedagogical pronunciation course as part of their teacher training program. The study’s main purpose was to understand the role of training in developing content knowledge (CK) and pedagogical content knowledge …

The State Of Global And African Ecology, Peter Knox

Landas

This article recounts the growth of concern for the environment in the latter half of the 20th Century, and its entry into Catholic magisterial theology. It expands on the ecological theory of planetary boundaries, and identifies how the theory surfaces in Pope Francis’ 2015 encyclical Laudato Si’. Based upon solid contemporary science, the encyclical is well founded to outline an appropriate and compassionate moral theology of care for creation. The article cites multiple instances where African people are at the nexus of environmental and social crises, focusing on how contemporary ecological factors affect women in particular. Environmental crises should not …

Developing Real-Time, Online Beam Control Of Uhdr Irradiators To Facilitate Flash Translational Investigations, Austin M. Sloop

Dartmouth College Ph.D Dissertations

The field of radiation oncology seeks novel techniques to increase the therapeutic ratio to treat malignancies while minimizing damage and toxicities in healthy tissues. While it was observed that delivering therapeutic doses at high dose rate could elicit lower biological effects over a half-century ago, the field of ultra-high dose rate (UHDR) radiation therapy (colloquially known as FLASH RT) has seen a resurgence in recent years due to an alignment of accelerator capability, dosimetric advances, and improved biotechnological techniques. This has opened the door to studying potential underlying mechanisms such that we may leverage the effects of FLASH tissue sparing …

Effectiveness Of Natural Coagulants In Purification Of Industrial Wastewater: A Case Of Cactus Pads And Watermelon Seeds, Neema O. Msuya

Tanzania Journal of Engineering and Technology (TJET)

This study assessed the potential of cactus pads and watermelon seeds as natural coagulants in industrial wastewater treatment. The global characterization of the two coagulants was done by using the Fourier Transform Infrared (FTIR) to determine the specific functional groups and by zeta potential measurements. A full factorial design was used to design the experiment and analyze the effect of three factors: coagulant dosage, settling time and particle size with three levels each and one replicate on the turbidity removal. ANOVA analyses were used to determine the significance of the factors. Results show that the amino and hydroxyl groups in …

Use Of Activated Palm Kernel Shells On Adsorption Of Heavy Metals (Cu2+ And Pb2+) From Contaminated Wastewater, Edwin N. Richard

Tanzania Journal of Engineering and Technology (TJET)

This research aimed to evaluate the adsorption capacity of low-cost agricultural waste adsorbent-activated palm kernel shells (APKS) for the removal of Pb2+ and Cu2+ ions from synthetic wastewater that had the concentration of copper and lead ions comparable to that of waste produced in Tanzanian research and teaching laboratories. This study was carried out in batch and continuous column adsorption reactors. The study examined the influence of particle size (0.71 mm–2.36 mm), pH (4.5–8.6), adsorbent dose (5–20 mg/L) and initial concentration Ci (1.93– 4 mg/l) on APKS adsorption removal efficiency. The batch results indicated that under alkali conditions (pH 8.4 …

Pembrolizumab Plus Chemotherapy In Frontline Treatment Of Advanced Ovarian Cancer: Clinical And Translational Results From A Phase 2 Trial, Jeffrey A How, Minghao Dang, Sanghoon Lee, Bryan Fellman, Shannon N Westin, Anil K Sood, Nicole D Fleming, Aaron Shafer, Ying Yuan, Jinsong Liu, Li Zhao, Joseph Celestino, Richard Hajek, Margaret B Morgan, Edwin R Parra, Caddie D Laberiano Fernandez, Claudio A Arrechedera, Luisa Maren Solis Soto, Kathleen M Schmeler, Alpa Nick, Karen H Lu, Robert Coleman, Linghua Wang, Amir A Jazaeri

Faculty, Staff and Student Publications

Background: The efficacy and feasibility of pembrolizumab combined with chemotherapy in frontline management of advanced high-grade epithelial ovarian cancer (EOC) is unknown. Additionally, modification of the tumor microenvironment following neoadjuvant therapy is not well understood.

Methods: In this single-arm phase 2 trial (this study was registered at ClinicalTrials.gov: NCT02520154), eligible patients received up to 4 cycles of neoadjuvant chemotherapy followed by interval cytoreduction, 3 cycles of adjuvant intravenous carboplatin/weekly paclitaxel/pembrolizumab, and finally maintenance pembrolizumab until progression or toxicity (maximum 20 cycles). The primary endpoint was progression-free survival (PFS). Secondary endpoints included feasibility, toxicity, and overall survival (OS). PD-L1 staining, …

Sitravatinib In Combination With Nivolumab Plus Ipilimumab In Patients With Advanced Clear Cell Renal Cell Carcinoma: A Phase 1 Trial, Pavlos Msaouel, Kai Yu, Ying Yuan, Jianfeng Chen, Xinmiao Yan, Menuka Karki, Fei Duan, Rahul A Sheth, Priya Rao, Kanishka Sircar, Amishi Y Shah, Amado J Zurita, Giannicola Genovese, Min Li, Chih-Chen Yeh, Minghao Dang, Guangchun Han, Yanshuo Chu, Max Hallin, Peter Olson, Rui Yang, Daniela Slavin, Hirak Der-Torossian, Curtis D Chin, Nizar M Tannir, Linghua Wang, Jianjun Gao

Faculty, Staff and Student Publications

We conducted a phase I trial to determine the optimal dose of triplet therapy with the tyrosine kinase inhibitor sitravatinib plus nivolumab plus ipilimumab in 22 previously untreated patients with advanced clear cell renal cell carcinoma. The primary endpoint was safety. Secondary endpoints were objective response rate (ORR), disease control rate (DCR), duration of response (DOR), progression-free survival (PFS), overall survival (OS), 1-year survival probability, and sitravatinib pharmacokinetics. Sitravatinib dose of 35 mg daily plus nivolumab 3 mg/kg and ipilimumab 1 mg/kg resulted in high frequency of immune-related adverse events. Subsequent dose reduction of ipilimumab to 0.7 mg/kg allowed safe …

Superstable Lipid Vacuoles Endow Cartilage With Its Shape And Biomechanics, Raul Ramos, Kim T Pham, Richard C Prince, Leith B Leiser-Miller, Maneeshi S Prasad, Xiaojie Wang, Rachel C Nordberg, Benjamin J Bielajew, Jerry C Hu, Kosuke Yamaga, Ji Won Oh, Tao Peng, Rupsa Datta, Aksana Astrowskaja, Axel A Almet, John T Burns, Yuchen Liu, Christian Fernando Guerrero-Juarez, Bryant Q Tran, Yi-Lin Chu, Anh M Nguyen, Tsai-Ching Hsi, Norman T-L Lim, Sandra Schoeniger, Ruiqi Liu, Yun-Ling Pai, Chella K Vadivel, Sandy Ingleby, Andrew E Mckechnie, Frank Van Breukelen, Kyle L Hoehn, John J Rasweiler, Michinori Kohara, William J Loughry, Scott H Weldy, Raymond Cosper, Chao-Chun Yang, Sung-Jan Lin, Kimberly L Cooper, Sharlene E Santana, Jeffrey E Bradley, Michael A Kiebish, Michelle Digman, David E James, Amy E Merrill, Qing Nie, Thomas F Schilling, Aliaksandr A Astrowski, Eric O Potma, Martín I García-Castro, Kyriacos A Athanasiou, Richard R Behringer, Maksim V Plikus

Faculty, Staff and Student Publications

Conventionally, the size, shape, and biomechanics of cartilages are determined by their voluminous extracellular matrix. By contrast, we found that multiple murine cartilages consist of lipid-filled cells called lipochondrocytes. Despite resembling adipocytes, lipochondrocytes were molecularly distinct and produced lipids exclusively through de novo lipogenesis. Consequently, lipochondrocytes grew uniform lipid droplets that resisted systemic lipid surges and did not enlarge upon obesity. Lipochondrocytes also lacked lipid mobilization factors, which enabled exceptional vacuole stability and protected cartilage from shrinking upon starvation. Lipid droplets modulated lipocartilage biomechanics by decreasing the tissue's stiffness, strength, and resilience. Lipochondrocytes were found in multiple mammals, including humans, …

Molecular Dynamics At Immune Synapse Lipid Rafts Influence The Cytolytic Behavior Of Car T Cells, Ahmed Z Gad, Jessica S Morris, Lea Godret-Miertschin, Melisa J Montalvo, Sybrina S Kerr, Harrison Berger, Jessica C H Lee, Amr M Saadeldin, Mohammad H Abu-Arja, Shuo Xu, Spyridoula Vasileiou, Rebecca M Brock, Kristen Fousek, Mohamed F Sheha, Madhuwanti Srinivasan, Yongshuai Li, Arash Saeedi, Kandice R Levental, Ann M Leen, Maksim Mamonkin, Alexandre Carisey, Navin Varadarajan, Meenakshi Hegde, Sujith K Joseph, Ilya Levental, Malini Mukherjee, Nabil Ahmed

Faculty, Staff and Students Publications

Chimeric antigen receptor T cells (CART) targeting CD19 through CD28.ζ signaling induce rapid lysis of leukemic blasts, contrasting with persistent tumor control exhibited by 4-1BB.ζ-CART. We reasoned that molecular dynamics at the CART immune synapse (CARIS) could explain differences in their tumor rejection kinetics. We observed that CD28.ζ-CART engaged in brief highly lethal CARIS and mastered serial killing, whereas 4-1BB.ζ-CART formed lengthy CARIS and relied on robust expansion and cooperative killing. We analyzed CARIS membrane lipid rafts (mLRs) and found that, upon tumor engagement, CD28.ζ-CAR molecules rapidly but transiently translocated into mLRs, mobilizing the microtubular organizing center and lytic granules …