Digital Commons Network^™

N-Glycosylation In The Serpin Domain Of The C1-Esterase Inhibitor In Hereditary Angioedema, Zhen Ren, John Bao, Shuangxia Zhao, Nicola Pozzi, H. James Wedner, John P. Atkinson

2020-Current year OA Pubs

Hereditary angioedema is an autosomal dominant disorder caused by defects in C1-esterase inhibitor (C1-INH), resulting in poorly controlled activation of the kallikrein-kinin system and bradykinin overproduction. C1-INH is a heavily glycosylated protein in the serine protease inhibitor (SERPIN) family, yet the role of these glycosylation sites remains unclear. To elucidate the functional impact of N-glycosylation in the SERPIN domain of C1-INH, we engineered 4 sets consisting of 26 variants at or near the N-linked sequon (NXS/T). Among these, 6 are reported in patients with hereditary angioedema and 5 are known C1-INH variants without accessible clinical histories. We systematically evaluated their …

Protein Translation Rates Are Negatively Correlated With Lifespan In Inbred Drosophila Strains, Harper S Kim, Madison M Hardiman, Andrew M Pickering

Faculty, Staff and Student Publications

No abstract provided.

Chemical Emergency Preparedness: Chempack & Its Contents, Grace Feigl

All Other Contributions

No abstract provided.

A Phenomenological Study Exploring The Lived Experiences Of Former Adult Drug Users’ Sobriety Journey After Graduating From A Faith-Based/Spiritual Drug And Alcohol Recovery Program, Laurine Voltaire

Doctoral Dissertations and Projects

The purpose of this transcendental phenomenological study was to investigate the lived experiences of former adult drug users and their sobriety journeys after graduating from a variety of faith-based or spiritual drug and alcohol recovery programs. The research included a systematic review and narrative synthesis of existing literature on faith-based and spiritual recovery programs to address the gap concerning the lived experiences of former users and an evaluation of the strategies and techniques vital for facilitating recovery. The guiding theoretical framework CHIME-D delineated the essential definitive characteristics such as connectedness, hope, identity, meaning of life, empowerment, and overcoming difficulties that …

The Masculine Perspective Of The Stigmatization Of Childlessness In Marriage In YorùBáLand: An Ile-Ife Phenomenological Study, Godwin Segun-George Olugbami

Doctoral Dissertations and Projects

The purpose of this phenomenological study was to describe men's experiences with the stigmatization of childlessness in the context of marriage in Ile-Ife, Nigeria. The experience of childlessness as a universal phenomenon has been predominantly studied from the female perspective, and men are primarily neglected. The heteronormative ideal of women as 'mother/nurturer' is supported by only collecting women's fertility data in contrast to relatively suboptimal statistics in men's studies. This dissertation explores the view of ten African men set in the Yorùbá culture suffering from childlessness and its attendant stigmatization, mainly as a result of infertility. It provides in-depth interviews …

An Examination Of Maternal Messages Given To Academically Successful African American Undergraduate Males By Their Single Mothers, Denee' Scott-Elliott

Doctoral Dissertations and Projects

The purpose of this phenomenological study was to examine the lived experiences of successful African American undergraduate males from single-parent homes, and the maternal messages that contributed to their academic success and resilience. Research shows that African American males face an icreased risk of academic underachievement, particularly those raised by single mothers. The participants consisted of African American undergraduate males who grew up in a single-parent home headed by their mother. For the purpose of this study, academically successful males were defined as males enrolled in a Historically Black College or University (HBCU) in the District of Columbia, Maryland and …

Investigating The Correlation Between Racially Based Trauma And The Imposter Phenomenon In High-Achieving Black Women, Tarra Lynn Winfield Ray

Doctoral Dissertations and Projects

This study investigates the imposter phenomenon, racially based trauma, and how the two correlate among high-achieving Black women. High achieving for this writing refers to Black women who attend college or graduate school, those in professional positions that require a degree, advanced degree, or professional licensure (i.e., corporate executives, medical doctors, attorneys, mental health clinicians, etc.), and entrepreneurs. Many current studies have focused on the unique and complex experiences that high-achieving Black women face while working to achieve goals and gain success. Many of these women have experienced racially based trauma, and many endorse the simultaneous experiencing of the imposter …

Caring For Ukrainian Healthcare Professionals In Wartime: Moral Injury And Psycho-Spiritual Intervention, Rodger L. Stenger

Doctoral Dissertations and Projects

This mixed-methods study examined the prevalence of Moral Injury (MI) among Ukrainian healthcare professionals (UHCPs) and their willingness to engage in evidence-based, psycho-spiritual interventions targeting MI that has resulted from the Russian invasion and the COVID-19 pandemic. MI is a psychological construct resulting from actions that violate an individual’s moral code and can overlap with Post Traumatic Stress Disorder (PTSD) symptoms. While MI has been extensively researched in the military, it has gained attention in healthcare settings. Utilizing the Moral Injury Symptom Scale-Healthcare Professional (MISS-HP), this study quantitatively identified a moderate prevalence of MI among doctors and nurses in Ukraine. …

Associations Between Deficit Accumulation Frailty And Baseline Markers Of Lifestyle In The Us Pointer Trial, Mark A Espeland, Yitbarek N Demesie, Kayloni Olson, Samuel N Lockhart, Sarah E Tomaszewski Farias, Maryjo L Cleveland, Christy C Tangney, Lucia Crivelli, Heather M Snyder, Michele K York, Laura D Baker, Rachel A Whitmer, Rena R Wing, Katelyn R Garcia, Kathryn E Callahan

Faculty, Staff and Students Publications

BACKGROUND: Multidomain lifestyle interventions may have the potential to slow biological aging as captured by deficit accumulation frailty indices. We describe the distribution and composition of the 49-component frailty index developed by the U.S. POINTER clinical trial team of investigators and assess its cross-sectional associations with sociodemographic factors and markers chosen to be representative of behaviors targeted by the trial's multidomain interventions.

METHODS: We draw baseline data from the 2 111 volunteers enrolled in U.S. POINTER who were ages 60-79 years and at increased risk for cognitive decline. Frailty components were grouped into 9 domains. Associations that frailty index scores …

Discontiguous Recurrences Of Idh-Wildtype Glioblastoma Share A Common Origin With The Initial Tumor And Are Frequently Hypermutated, Malcolm F Mcdonald, Sricharan Gopakumar, Tareq A Juratli, Ilker Y Eyüpoglu, Ganesh Rao, Jacob J Mandel, Ali Jalali

Faculty, Staff and Students Publications

Glioblastoma is the deadliest primary brain tumor, largely due to inevitable recurrence of the disease after treatment. While most recurrences are local, patients rarely present with a new discontiguous focus of glioblastoma. Little is currently known about the genetic profile of discontiguous recurrences. In our institutional database, we identified 22 patients with targeted exome sequencing of pairs of initial and recurrent IDH-wildtype glioblastoma. Recurrences were classified as contiguous or discontiguous based on the presence or absence of T2 FLAIR signal connection to the initial site of disease on MRI. Exome analysis revealed shared driver and passenger mutations between discontiguous recurrences …

Sex Differences In Response To Diet Enriched With Glutathione Precursors In The Aging Heart, Aude Angelini, Grecia Garcia Marquez, Anna Malovannaya, Marta L Fiorotto, Alexander Saltzman, Antrix Jain, Joann Trial, George E Taffet, Katarzyna A Cieslik

Faculty, Staff and Students Publications

Common features of the aging heart are dysregulated metabolism, inflammation, and fibrosis. Elevated oxidative stress is another hallmark of cardiac aging that can exacerbate each of these conditions. We hypothesize that by increasing natural antioxidant levels (glutathione), we will improve cardiac function. Twenty-one-month-old mice were fed glycine and N-acetyl cysteine (GlyNAC; glutathione precursors)-supplemented or control diets for 12 weeks. Heart function was monitored longitudinally, and the exercise performance was determined at the end of the study. We found that the GlyNAC diet was beneficial for old male but not old female mice, leading to an increase of Ndufb8 expression (a …

Preformulation Study Of Kigelia Africana Fruit Ethanolic Extract As Topical Preparations, Tareq Maqlam, Abdullah H Maad, Mohammed E Shayoub, Zuheir Osman

Al-Ameed Journal for Medical Research and Health Sciences

Background: Preformulation studies have a significant role in anticipating formulation problems and identifying logical paths in dosage form technology.

Aim: This study aimed to evaluate the preformulation criteria of the aquatic ethanol extract of Kigelia africana fruit as topical antibacterial therapy.

Methods: The preformulation parameters of the extract were evaluated by testing its organoleptic characteristics, melting point, pH, spectroscopic assay, stability, solubility, and partition coefficient.

Results: The study demonstrated that the extract possessed satisfactory organoleptic properties, a melting point of 195.3–198.0 °C, a pH of 6.26, chemical stability under acidic conditions, photostability, higher solubility in basic conditions and in the …

Political Communication, Paul A. Soukup S.J.

Communication Research Trends

No abstract provided.

The State Of Ong Scholarship - A Symposium At Gonzaga University, Sara Van Den Berg, Thomas D. Zlatic, Paul A. Soukup, James Jarc, Kristina J. Morehouse, Heather M. Crandall, Dung Q. Tran, Kateland Wolfe

Communication Research Trends

No abstract provided.

Addressing The Needs Of Jewish Clients And Students Through A Trauma-Informed Approach, Amiya Waldman-Levi, Robin Akselrud, Zahava L. Friedman, Lola Halperin, Shifra K. Leiser, Rivka Molinsky

The Open Journal of Occupational Therapy

The worldwide Jewish community is notoriously nomadic because of persecution and displacement through several millennia. The diasporic experience of global Jewish communities led to traumatic events such as historical expulsion and genocide. These experiences embody all five components of occupational injustice. The recent rise in antisemitism has triggered intergenerational trauma among individuals, families, and communities. This paper, grounded in trauma-based research, aims to guide occupational therapists treating Jewish clients and/or teaching Jewish students. The paper outlines trauma-informed implications for therapist-client collaboration in the context of supporting occupational justice for diverse populations. The distinct role of occupational therapists in effectively serving …

Comprehensive Breast Cancer-Related Lymphedema Management Programs Addressing Both Psychosocial And Physical Needs: A Scoping Review, Amanda Wheeler, Claudine Campbell, Chenchen Cui

The Open Journal of Occupational Therapy

Background: Breast cancer is the leading cause of female cancer worldwide, which can lead to many negative sequelae, with up to a third of women developing breast cancer-related lymphedema. Breast cancer-related lymphedema requires chronic maintenance and is associated with worse physical and mental health outcomes compared to women without lymphedema. Occupational therapists are well-positioned to address the complex needs of women with breast cancer-related lymphedema. This review aimed to identify existing research that reports outcomes of lymphedema management programs addressing both physical and mental health needs of women with breast cancer-related lymphedema.

Method: A scoping review was conducted …

Psychometric Development Of Scales Measuring Attitudes About And Interest In Integrated Healthcare Clinical Practice, Mark Cassano, Robert A. Ditomasso, Barbara A. Golden, Scott D. Glassman

The Journal of Integrated Primary Care

The landscape of integrated healthcare models continues to evolve, and with these changes, providers are facing the challenge of adopting approaches to care that may not have been taught in their training. With interprofessional education on the rise, some providers often struggle to modify their clinical methodology to accommodate an interdisciplinary team-based care format. In an effort to better understand the attitudes and interest levels that may affect a provider’s engagement in these models of care, the Integrated Health Attitudes and Interest Scales were developed. Using a best practices model, items for the measure were created by the investigators and …

Mitochondrial A3 Adenosine Receptor As A Mechanism For The Protective Effects Of A3ar Agonists On Chemotherapy-Induced Neuropathic Pain, Timothy M. Doyle, Kali Janes, Wen Hua Xiao, Grant R. Kolar, Hans F. Luecke, Michael Anne Gratton, Dilip K. Tosh, Kenneth A. Jacobson, Gary J. Bennett, Daniela Salvemini

Biological Sciences Faculty Research & Creative Works

Alterations in mitochondrial function are the linchpin in numerous disease states including in the development of chemotherapy-induced neuropathic pain (CIPN), a major dose-limiting toxicity of widely used chemotherapeutic cytotoxins. In CIPN, mitochondrial dysfunction is characterized by deficits in mitochondrial bioenergetics (e.g., decreased ATP production) that are thought to drive the degeneration of the peripheral nerve sensory axon terminal sensory arbors in the skin (the intraepidermal nerve fibers; IENFs) and induce abnormal spontaneous discharge in peripheral nerve sensory axons. Preserving mitochondrial function is anticipated to prevent CIPN. We have now discovered that the G-protein-coupled receptor, A3 adenosine receptor subtype (A3AR), is …

Child Marriage In Tanzania: Loopholes, Duct Tape, And Lesser Evils, Sheryl L. Buske

Tulsa Law Review

No abstract provided.

The Next Public Health Frontier With Indoor Air Quality, Lynette B. Martins

Tulsa Law Review

No abstract provided.

Meditation In Qualitative Research For Bracketing And Beyond, Katalin Grajzel

Research Methods and Statistics: Graduate Student Scholarship

In this study, I recounted my experience using mantra meditation during a phenomenological study for the purposes of bracketing. The efficacy and purpose of bracketing have been debated from Husserl (1931), whose aimed was to achieve objectivity, to Heidegger (1962) who advocated for immersion of the researcher, through the French school (Merleau-Ponty, 1964) of middle ground, by whom bracketing was seen as the process to unearth and suspend biases for the better understanding of participants’ experiences (Arsel, 2017; Creswell & Creswell, 2017; Creswell & Poth, 2016; Fischer & Guzel, 2023). In this study, however, I propose another approach to bracketing …

Pharmacotherapeutic Efficacy Of Astaxanthin Toward Breast Cancer: A Systematic Review, Harnd Abdullah Ali, Bushra Hassan Marouf, Lanja Ibraheim Saeed, Rafl M. Kamil, Savan Mohammed Dilshad

BioMed Visions Journal

Background: Breast cancer (BC) is one of the most common malignancies in women, characterized by the malignant proliferation of breast epithelial cells that significantly impairs patients’ quality of life. Astaxanthin (ASN), a marine-derived xanthophyll carotenoid, is known for its antioxidant and anti-inflammatory properties. Emerging evidence suggests that ASN may exert anti-neoplastic effects by inhibiting tumorigenesis and suppressing the growth and progression of BC cells. This systematic review aims to critically evaluate the therapeutic potential of ASN as a pharmacological agent in the prevention and management of breast cancer.

Methodology: Following PRISMA 2020 guidelines, a comprehensive literature search was conducted in …

January 15, 2025 Faculty Senate Minutes, University Of South Carolina

Faculty Senate

No abstract provided.

Detection Of Elder Abuse Through Emergency Care Technicians Screening Tool Revision For Home-Based Primary Care (Detect-Rpc): A Cluster Randomised Controlled Trial Study Protocol, Brad Cannell, Nicholas Sevey, Melvin D Livingston, Jason Burnett, Kristin Lees Haggerty, Carolyn Pickering

Faculty, Staff and Student Publications

Introduction: The annual prevalence of elder mistreatment (EM) in cognitively intact older adults is estimated to be 11%, yet the annual prevalence in older adults with Alzheimer's disease and related dementias (AD/ADRD) is estimated to be as high as 75%. Associated with a decrease in quality of life and increase in risk of mortality, EM represents a significant public health burden. Home-based primary care (HBPC) providers are uniquely positioned to address the critical need for robust EM screening and reporting, especially among individuals with AD/ADRD. This protocol seeks to adapt the Detection of Elder mistreatment Through Emergency Care Technicians (DETECT) …

Performance Art Is Ripe For Layering: Performance Art As A Therapeutic Intervention, Nur Greene

Expressive Therapies Capstone Theses

Performance art is an artform which benefits Expressive Arts Therapy (ExAT), the field of expressive therapies, and the mental health profession itself. For the purposes of this literature review, performance art is defined as any expression which attempts to be transformative, is witnessed by self or other, matching at least two modes of creative expression, often interacting with those witnessing, and which offers some element of experiment. Expressive Arts Therapy, a modality of therapy within the expressive therapies aimed to move (transfer) creative expression from one artform to another and develop a connection between different artistic representations and one’s psyche, …

Connotation, Research Status, And Development Directions Of Clean Coal Geology In China, Tang Yuegang, Wang Shaoqing, Wang Xiaoshuai, Guo Xin, Wang Yafeng, Xue Liping, Harold H. Schobert

Coal Geology & Exploration

Objective The exploration and assessment of low-carbon, zero-emission, and maximized utilization of coal resources, emerge as a focus of coal geology in the 21st century. [Research Advances] Based on the research content of coals and coal geology, along with the domestic and international development trends of clean coal technology (CCT), this study defines clean coal geology in the broad and narrow sense. Clean coal geology in the narrow sense focuses on the geological and geochemical issues related to efficiency enhancement and emission reduction in coal processing and utilization. In contrast, clean coal geology in the broad sense emphasizes …

Advanced Prediction Of Events And Temporal Expressions In Medical Text Using The Jena Api: Integrating Ontologies And Deep Learning, Hafida Tiaiba, Lyazid Sabri, Okba Kazar

Turkish Journal of Electrical Engineering and Computer Sciences

The automatic recognition of medical concepts and temporal expressions in narrative clinical text enhances the utility of electronic health records (EHRs) and supports clinical decision-making and research. However, challenges arise due to the complexity of medical language, ambiguity of terms, and variability in expression. To address these issues, the use of medical ontologies significantly improves data management in healthcare. A novel approach integrates various medical ontologies covering drugs, symptoms, diseases, anatomy, disease drivers, and food, and with convolutional neural networks (CNNs) -including Standard, Transposed, and Separable convolution models (CONSEPTR)- to extract both medical events (e.g., clinical departments, treatments, problems) and …

Adverse Childhood Experiences: Healing Through Storytelling And Mindful Narrative Therapy, Julie Kemp

Mindfulness Studies Theses

This study presents research about the nature and prevalence of adverse childhood experiences (ACEs), the mental and physical impacts to individuals exposed to ACEs, and incorporating mindfulness practices into therapeutic approaches to treating them, particularly Mindfulness-Based Narrative Therapy (MBNT). It is important because ACEs have become a global crisis, with the potential for interfering with psychological and physical development, early mortality, and other harmful life outcomes. This thesis provides critical information for mindfulness teachers and practitioners, therapists, educators, regulators, parents, and individuals subjected to ACEs.

The methodology includes extensive literature searches for narrative therapy and mindfulness-based interventions (MBIs) in peer-reviewed …

Nonviolent Communication For The Inner Dialogue Of Women With Adhd, Mary-Carmen Wiser

Mindfulness Studies Theses

This study provides a theoretical framework suggesting that nonviolent communication (NVC) can alleviate the violence frequently experienced in the inner dialogue of women with Attention Deficit/Hyperactive Disorder (ADHD). Due to the high correlation between ADHD symptoms in women and elevated rates of anxiety, depression, engagement in self-harm, and internalized self-criticism, exploring methods to mitigate negative self-dialogue is essential. Research on NVC indicates that individuals can cultivate empathy and compassion in interpersonal communication, suggesting potential benefits for addressing challenges in intrapersonal communications that often stem from the internalized presentation of ADHD symptoms in women. The gender gap in ADHD diagnosis, which …

Benchmarking Spatial Co-Localization Methods For Single-Cell Multiplex Imaging Data With Applications To High-Grade Serous Ovarian And Triple Negative Breast Cancer., Alex C. Soupir, Ishaan V. Gadiyar, Bryan R. Helm, Coleman R. Harris, Simon N. Vandekar, Lauren C. Peres, Robert J. Coffey, Julia Wrobel, Siyuan Ma, Brooke L. Fridley

Manuscripts, Articles, Book Chapters and Other Papers

Single-cell multiplex imaging (scMI) measures cell locations and phenotypes within a tissue and can be used to understand the tumor microenvironment. In scMI studies, it is often of interest to quantify spatial co-localization of immune cells and its association with clinical outcomes; however, it remains unknown which of the many available spatial indices have adequate power to detect spatial within-sample co-localization and its association with patient outcomes, such as survival. In this study, the performance of six frequentist metrics of spatial co-localization used in scMI studies were evaluated. Simulated data was used to assess the power and type I error …