Digital Commons Network^™

Antidiabetic Properties Of Prickly Pear (Opuntia Ficus-Indica) Fruit Extract, Kenzy Aidan Joseph Mckay

The Undergraduate Research Journal

Diabetes mellitus is a metabolic disorder that claims 1.5 million lives annually. Opuntia ficus-indica, commonly known as the prickly pear, has been commonly used in traditional folk medicine for its hypoglycemic properties. It has been claimed that it has antimicrobial and antioxidant properties as well. The plant is native to Mexico and is commonly found in the middle east and India and folk medicine from all of these areas have been using prickly pear medicinally for years. To test these claims an extract of locally sourced Opuntia ficus-indica was prepared using the flesh and seeds of the fruit. The …

Reflections On Using A Strength-Based Culturally Sensitive Community Psychology Approach To Promoting Sexual Health Of Egyptian Women And Girls, Salma Elhabashi, Farida Elrefaie, Zeina M. Shahine

The Undergraduate Research Journal

Navigating the intricate landscape of sexual and reproductive health (SRH) poses considerable challenges, especially within societies where the discourse is shaped by deeply rooted traditions and cultural norms. This paper examines a research project aimed at addressing the critical gap in dialogue surrounding women's SRH in Egypt. Adopting a community psychology framework, this project has two components: a mother-daughter communication guidebook and a comprehensive needs assessment survey. The guidebook was designed to facilitate discussions during the critical transitional phase of puberty, and the needs assessment survey aimed to understand the distinct needs of Egyptian women using a strengths-based approach. By …

Mechanisms Of Inflammation And Regeneration In The Eye, Yiming Zhang

Arts & Sciences Electronic Theses and Dissertations

Fasting and caloric restriction are effective to treat patients with pre-diabetes or metabolic dysfunction-associated steatotic liver disease (MASLD), previously known as non-alcoholic fatty liver disease (NAFLD), but intensive lifestyle changes are difficult for many to implement and sustain. Therefore, by identifying and studying fasting-mediated signals, we hope to elicit and convey the therapeutic effects of fasting against MASLD without actual physiological fasting. We discovered a key pathway in the liver through unbiased transcriptomic screening in fasted mice, a novel glucose fasting-activated effector: the amino acid hydrolase, arginase 2 (ARG2). Our previously published data demonstrates that forced hepatocyte-specific Arg2 overexpression is …

Local Baptist Leader, Jason Ballard, Featured Speaker For Gardner-Webb Greene Lectureship, Office Of University Communications

Gardner-Webb NewsCenter Archive

Jason Ballard, associational mission strategist for the Greater Cleveland County Baptist Association (GCCBA) in Shelby, N.C., is the speaker for the C.O. and Eliza Greene Endowed Lectureship on Tuesday, March 4, at Gardner-Webb University. His topic is “Leading Change in the Local Church.”

February 5, 2025 Faculty Senate Minutes, University Of South Carolina

Faculty Senate

No abstract provided.

Future Scenarios Of Adoption Sustainable Materials By Construction Firms In The United Arab Emirates, Mona Albeshr

Theses

The construction industry accounts for 39% of greenhouse gas emissions, and change is required, especially with the Net Zero initiative. UAE construction companies must evaluate their current positions and update their strategies to support government regulations. Building futuristic communities is crucial for expanding the built environment within the country; however, the types of materials used should account for two aspects: sustainability and climate resilience, and both must be considered whenever these construction companies formulate their strategic response. Hence, scenario planning significantly provides valuable insights to decision-makers in construction companies’ strategic departments to envision four plausible scenarios of the external environment …

The Lumberjack, February 05, 2025

Cal Poly Humboldt's Student Newspaper

The student newspaper of Humboldt State University.

Comparing In-Person, Standard Telehealth, And Remote Musculoskeletal Examination With A Novel Augmented Reality Exercise Game System: Pilot Cross-Sectional Comparison Study, Richard Wu, Keerthana Chakka, Sara Belko, Ninad Khargonkar, Kevin Desai, Balakrishnan Prabhakaran, Thiru Annaswamy

SKMC Student Presentations and Publications

BACKGROUND: Current telemedicine technologies are not fully optimized for conducting physical examinations. The Virtual Remote Tele-Physical Examination (VIRTEPEX) system, a novel proprietary technology platform using a Microsoft Kinect-based augmented reality game system to track motion and estimate force, has the potential to assist with conducting asynchronous, remote musculoskeletal examinations.

OBJECTIVE: This pilot study evaluated the feasibility of the VIRTEPEX system as a supplement to telehealth musculoskeletal strength assessments.

METHODS: In this cross-sectional pilot study, 12 study participants with upper extremity pain and/or weakness underwent strength evaluations for four upper extremity movements using in-person, telehealth, VIRTEPEX, and composite (telehealth plus VIRTEPEX) …

Advances In Pyrazolo[1,5-A]Pyrimidines: Synthesis And Their Role As Protein Kinase Inhibitors In Cancer Treatment, Terungwa H. Iorkula, Osasere Jude Kelly Osayawe, Daniel A. Odogwu, Latifat Oluwatobi Ganiyu, Emmanuel Faderin, Raymond Femi Awoyemi, Busayo Odunayo Akodu, Ikhazuagbe Hilary Ifijen, Omowunmi Rebecca Aworinde, Peter Agyemang, Odo Lovelyn Onyinyechi

Michigan Tech Publications

Pyrazolo[1,5-a]pyrimidines are a notable class of heterocyclic compounds with potent protein kinase inhibitor (PKI) activity, playing a critical role in targeted cancer therapy. Protein kinases, key regulators in cellular signalling, are frequently disrupted in cancers, making them important targets for small-molecule inhibitors. This review explores recent advances in pyrazolo[1,5-a]pyrimidine synthesis and their application as PKIs, with emphasis on inhibiting kinases such as CK2, EGFR, B-Raf, MEK, PDE4, BCL6, DRAK1, CDK1 and CDK2, Pim-1, among others. Several synthetic strategies have been developed for the efficient synthesis of pyrazolo[1,5-a]pyrimidines, including cyclization, condensation, three-component reactions, microwave-assisted methods, and green chemistry approaches. Palladium-catalyzed crosscoupling …

Single Amino Acid Changes Impact The Ability Of Drosophila Melanogaster Cecropins To Inhibit Growth Of Providencia Pathogens, Sarah Smith, Marla Forfar, Christopher Feudale, Lauren Shaffer, Grace Ginder, Marion Duval, Quinn Smith, Moria C. Chambers

Faculty Journal Articles

As antibiotic-resistant bacteria spread worldwide, the need to develop novel antimicrobial agents is urgent. One rich source of potential antimicrobials is the insect immune system, as insects produce a wide range of antimicrobial peptides (AMPs) with diverse sequences and structures. Insects also encounter many bacterial pathogens, some of which are closely related to pathogens of clinical relevance. However, despite interest in AMPs as therapeutics, the relationships between the amino acid sequence, biophysical properties, antimicrobial activity, and specificity are still not generalizable. To improve our understanding of these relationships, we assessed how single amino acid changes in cecropin AMPs produced by …

Preparing Students For Civic Engagement: Cultivating Critical Dialogue In Stem Classrooms, Bryan Dewsbury, Carrie Diaz Eaton

All Faculty Scholarship

Thriving democracies require engaged citizens who possess skills pertaining to critical thinking, respectful discourse, and an appreciation of the value of difference. In this chapter, we discuss ways in which we cultivate these skills in STEM classrooms at two demographically different institutions of higher education and course types. Leaning on scholarship that shows the positive impacts of creating community and belonging, we make the case that civic participation is a critical value that should be agnostic to course type. Suggestions for transferability and institution-specific considerations will also be discussed.

Reforming Grading At The University Of Mississippi, Josh Eyler

Events

We are currently in the midst of one of the most fruitful, effective periods of grading reform in our country's history, both in K-12 and in higher ed. At many institutions, including our own, faculty are experimenting with a variety of alternative grading strategies and are having success, but many are eager to see more widespread change at the department and institutional levels. This session provides attendees with research-based tools for advancing grading reform initiatives at scale and provides participants with strategies for moving the conversation forward. Lunch will be provided for registered participants.

A Critical Appraisal Of The Evidence On Racial Disproportionality In Special Education, Rachel E. Fish, Kenneth Shores, Joào M. Souto Maior

Education and Child Study: Faculty Publications

This essay provides a two-pronged critical assessment of a subset of the literature on racial disproportionality in special education: that which aims to estimate racial disparities among otherwise similar children. This body of research has shown that Black students are less likely than comparable White students to receive special education, and has been interpreted by many to mean that current policies meant to reduce Black over-representation may be exacerbating inequality. Our essay argues that this subset of research has fundamental limitations in its covariate adjustment practices and its data quality, making “under-representation” findings questionable. We argue that caution and further …

The Bg News February 5, 2025, Bowling Green State University

BG News (Student Newspaper)

The BGSU campus student newspaper. February 5, 2025. Volume 104-Issue 16.

An Open-Label Study To Determine The Maximum Tolerated Dose Of Oral Esk-440 Administered As A Single Agent In Patients With Advanced Or Metastatic Solid Tumors, Russell J. Schilder, Drew Rasco, Manish R. Sharma

Kimmel Cancer Center Faculty Papers

PURPOSE: Anaplastic lymphoma kinase (ALK) dysregulation is implicated in numerous cancers. Tyrosine kinase inhibitors (TKIs) targeting ALK have improved disease outcomes, but resistance mechanisms are common. This first-in-human trial evaluates ESK-440, a dual inhibitor of ALK and focal adhesion kinase, as a novel strategy for cancers with resistance to ALK-targeting TKIs.

METHODS: This phase 1, open-label, dose-finding study evaluated the maximum tolerated dose (MTD), safety, efficacy, and pharmacokinetics of ESK-440 in participants with advanced or metastatic solid tumors (ClinicalTrials.gov: NCT01922752). A 3 + 3 dose-escalation design, with daily doses ranging from 25 to 700 mg/day of ESK-440 for each 28-day …

Factors Related To Employment Of Previously Incarcerated Individuals, Toni Victoria Lewis

Walden Dissertations and Doctoral Studies

Employment amongst previously incarcerated individuals is a concern of the criminal justice system because being employed is considered a mitigator of reincarceration. While there is research about the stigma of incarceration in gaining employment, little is known about the factors associated with individuals being able to find employment. The purpose of this quantitative, correlational study was to identify whether there is a direct correlation between individual demographic features and employment status of individuals after 1 year or more of previously being incarcerated in North Carolina. General strain theory was the theoretical framework. The key research question focused on how release …

Advanced External Beam Stereotactic Radiotherapy For Skull Base Reirradiation, He Wang, Fahed M Alsanea, Dong Joo Rhee, Xiaodong Zhang, Wei Liu, Jinzhong Yang, Zhifei Wen, Yao Zhao, Tyler D Williamson, Rachel A Hunter, Peter A Balter, Tina M Briere, Ronald X Zhu, Anna Lee, Amy C Moreno, Jay P Reddy, Adam S Garden, David I Rosenthal, Gary B Gunn, Jack Phan

Faculty, Staff and Student Publications

Background/objectives: Stereotactic body radiation therapy (SBRT) for skull base reirradiation is particularly challenging, as patients have already received substantial radiation doses to the region, and nearby normal organs may have approached their tolerance limit from prior treatments. In this study, we reviewed the characteristics and capabilities of four advanced external beam radiation delivery systems and four modern treatment planning systems and evaluated the treatment plan quality of each technique using skull base reirradiation patient cases.

Methods: SBRT plans were generated for sixteen skull base reirradiation patients using four modalities: the GK plan for the Elekta Leksell Gamma Knife Perfexion/ICON, the …

Brd7 Loss Reawakens Dormant Metastasis Initiating Cells In Lung By Forging An Immunosuppressive Niche, Jayanta Mondal, Junfeng Zhang, Feng Qing, Shunping Li, Dhiraj Kumar, Jason T Huse, Filippo G Giancotti

Faculty, Staff and Student Publications

Metastasis in cancer is influenced by epigenetic factors. Using an in vivo screen, we demonstrate that several subunits of the polybromo-associated BAF (PBAF) chromatin remodeling complex, particularly Brd7, are required for maintaining breast cancer metastatic dormancy in the lungs of female mice. Brd7 loss induces metastatic reawakening, along with modifications in epigenomic landscapes and upregulated oncogenic signaling. Breast cancer cells harboring Brd7 inactivation also reprogram the surrounding immune microenvironment by downregulating MHC-1 expression and promoting a pro-metastatic cytokine profile. Flow cytometric and single-cell analyses reveal increased levels of pro-tumorigenic inflammatory and transitional neutrophils, CD8+ exhausted T cells, and CD4+ stress …

Punch Cd3-Ols: A Phase 3 Prospective Observational Cohort Study To Evaluate The Safety And Efficacy Of Fecal Microbiota, Live-Jslm (Rebyota) In Adults With Recurrent Clostridioides Difficile Infection, Paul Feuerstadt, Teena Chopra, Whitfield Knapple, Nicholas W Van Hise, Erik R Dubberke, Brian Baggott, Beth Guthmueller, Lindy Bancke, Michael Gamborg, Theodore S Steiner, Daniel Van Handel, Sahil Khanna

2020-Current year OA Pubs

BACKGROUND: The aim of this study was to evaluate the safety and efficacy of fecal microbiota, live-jslm (RBL; REBYOTA)-the first single-dose, broad consortia microbiota-based live biotherapeutic approved by the US Food and Drug Administration for preventing recurrent Clostridioides difficile infection (rCDI) in adults following standard-of-care (SOC) antibiotic treatment.

METHODS: PUNCH CD3-OLS was a prospective, phase 3, open-label study, conducted across the US and Canada. Participants were aged ≥18 years with documented rCDI and confirmed use of SOC antibiotics. Participants with comorbidities including inflammatory bowel disease and mild-to-moderate immunocompromising conditions could be enrolled. A single dose of RBL was rectally administered …

Socioeconomic Determinants Of Health And Well-Being In A Low Resource Setting: A Case Of Older Adults Living In A Rural Setting In Northwestern Cambodia, Kakada Kuy

Brown School Graduate Student Theses and Dissertations

This dissertation examines the associations between socioeconomic factors, and physical and psychological well-being among older adults in Cambodia. Focusing on subjective and objective socioeconomic status (SES) and the mediating roles of social and welfare support, this dissertation consists of three interrelated chapters that address different facets of the relationships. Paper 1 (Chapter 2) investigates the demographic characteristics, socioeconomic factors, and social support structures among older Cambodians. Findings reveal significant gender and age disparities, with women and the oldest adults more likely to experience lower socioeconomic status and weaker social support. Paper 2 (Chapter 3) explores the associations between subjective and …

Streamlined Production, Protection, And Purification Of Enzyme Biocatalysts Using Virus-Like Particles And A Cell-Free Protein Synthesis System, Seung O. Yang, Joseph P. Talley, Gregory H. Nielsen, Kristen M. Wilding, Bradley Charles Bundy

Faculty Publications

Enzymes play an essential role in many different industries; however, their operating conditions are limited due to the loss of enzyme activity in the presence of proteases and at temperatures significantly above physiological conditions. One way to improve the stability of these enzymes against high temperatures and proteases is to encapsulate them in protective shells or virus-like particles. This work presents a streamlined, three-step, cell-free protein synthesis (CFPS) procedure that enables rapid in vitro enzyme production, targeted encapsulation in protective virus-like particles (VLPs), and facile purification using a 6× His-tag fused to the VLP coat protein. This process is performed …

Enhancing Care: Child Protective Service Workers’ Perspectives And Experiences Of Serving Children With Disabilities, Meekyung Han, Celia Rocio Murillo Lechuga, Gaby Solis

Faculty Research, Scholarly, and Creative Activity

Children with disabilities (CWD) are overrepresented in the child welfare system (CWS), yet limited research exists on how child protective service (CPS) workers respond. This exploratory qualitative study conducted semi-structured individual interviews with 12 CPS workers in Northern California to explore their experiences. Thematic analysis identified five key themes: contributors to maltreatment, challenges of working with CWD, the influence of personal/professional experience, collaboration with disability experts, and the need for training. Findings suggest that disability-focused training in the graduate Title IV-E program and ongoing professional training can enhance CPS workers’ competency and strengthen interactions with CWD, leading to better outcomes.

Acute Mecp2 Loss In Adult Mice Reveals Transcriptional And Chromatin Changes That Precede Neurological Dysfunction And Inform Pathogenesis, Sameer S Bajikar, Jian Zhou, Ryan O'Hara, Harini P Tirumala, Mark A Durham, Alexander J Trostle, Michelle Dias, Yingyao Shao, Hu Chen, Wei Wang, Hari Krishna Yalamanchili, Ying-Wooi Wan, Laura A Banaszynski, Zhandong Liu, Huda Y Zoghbi

Faculty, Staff and Students Publications

Mutations in the X-linked methyl-CpG-binding protein 2 (MECP2) gene cause Rett syndrome, a severe childhood neurological disorder. MeCP2 is a well-established transcriptional repressor, yet upon its loss, hundreds of genes are dysregulated in both directions. To understand what drives such dysregulation, we deleted Mecp2 in adult mice, circumventing developmental contributions and secondary pathogenesis. We performed time series transcriptional, chromatin, and phenotypic analyses of the hippocampus to determine the immediate consequences of MeCP2 loss and the cascade of pathogenesis. We find that loss of MeCP2 causes immediate and bidirectional progressive dysregulation of the transcriptome. To understand what drives gene downregulation, we …

Targeting Tiam1 Enhances Hippocampal-Dependent Learning And Memory In The Adult Brain And Promotes Nmda Receptor-Mediated Synaptic Plasticity And Function, Francisco A Blanco, Md Ali Bin Saifullah, Jinxuan X Cheng, Carlota Abella, Federico Scala, Karen Firozi, Sanyong Niu, Jin Park, Jeannie Chin, Kimberley F Tolias

Faculty, Staff and Students Publications

Excitatory synapses and the actin-rich dendritic spines on which they reside are indispensable for information processing and storage in the brain. In the adult hippocampus, excitatory synapses must balance plasticity and stability to support learning and memory. However, the mechanisms governing this balance remain poorly understood. Tiam1 is an actin cytoskeleton regulator prominently expressed in the dentate gyrus (DG) throughout life. Previously, we showed that Tiam1 promotes dentate granule cell synapse and spine stabilization during development, but its role in the adult hippocampus remains unclear. Here, we deleted Tiam1 from adult forebrain excitatory neurons (Tiam1^fKO) and assessed …

Neutralizing Antibody Immune Correlates For A Recombinant Protein Vaccine In The Covail Trial, Youyi Fong, Lauren Dang, Bo Zhang, Jonathan Fintzi, Shiyu Chen, Jing Wang, Nadine G Rouphael, Angela R Branche, David J Diemert, Ann R Falsey, Cecilia Losada, Lindsey R Baden, Sharon E Frey, Jennifer A Whitaker, Susan J Little, Satoshi Kamidani, Emmanuel B Walter, Richard M Novak, Richard Rupp, Lisa A Jackson, Chenchen Yu, Craig A Magaret, Cindy Molitor, Bhavesh Borate, Tara M Babu, Angelica C Kottkamp, Anne F Luetkemeyer, Lilly C Immergluck, Rachel M Presti, Martín Bäcker, Patricia L Winokur, Siham M Mahgoub, Paul A Goepfert, Dahlene N Fusco, Robert L Atmar, Christine M Posavad, Jinjian Mu, Mat Makowski, Mamodikoe K Makhene, Seema U Nayak, Paul C Roberts, Dean Follmann, Peter B Gilbert

Faculty, Staff and Students Publications

For COVAIL recipients of a coronavirus disease 2019 (COVID-19) Sanofi booster vaccine, neutralizing antibody titers were assessed as a correlate of risk (CoR) of COVID-19. Peak and exposure-proximal titers were inverse CoRs with covariate-adjusted hazard ratios (95% confidence intervals) 0.30 (0.11, 0.78) and 0.25 (0.07, 0.85) per 10-fold increase in weighted average titer.

Detection Of Parasite Dna In Soil Samples From Rural Yucatan, Mexico, Liliana E Villanueva-Lizama, Angela Cruz-Coral, Christian Teh-Poot, Julio Vladimir Cruz-Chan, Rojelio Mejia

Faculty, Staff and Students Publications

The soil is the primary environmental reservoir for many parasites transmitted to humans that cause disease. Our environmental study used a multiparallel real-time quantitative polymerase chain reaction assay to detect parasite DNA in soil collected from the outdoor built environments of 34 houses in rural Yucatan, Mexico. The number of positive houses (n, %) per parasite species was 18 (53%) for Acanthamoeba spp.; four (12%) for Blastocystis spp. and Ascaris lumbricoides; three (9%) for Toxocara canis; and one (3%) for Ancylostoma spp., Trichuris trichiura, Entamoeba histolytica, and Giardia intestinalis. No DNA from Necator americanus, Strongyloides stercoralis, Toxocara cati, or Cryptosporidium …

Models Of Judicial Interpretation: From Marshall To Kavanaugh And How The Umpire Model Changed The Game, Beau Sullivan

Ohio Northern University Law Review

The three predominant modes of judicial interpretation are living constitutionalism, originalism, and the umpire model. The living constitutionalist believes the Constitution is a living document that must change and adapt over time. The living constitutionalist considers the history, text, precedent, and policy when deciding a case. This is in contrast to the originalist, who considers the history and text of the document when deciding a case. The originalist favors judicial restraint and seeks to limit the role of the judge. The devotee of the umpire model champions the independent judge whose function is to the law and does not consider …

A Qualitative Analysis Of 14- To 17-Year-Olds’ Perceptions Of And Interest In Dietetics, Andrea Barney, Kelsey Mueller, Emily Patten

Journal of Dietetic Education

Objective: To understand 14-17-year-old youth’s perceptions of the field of dietetics and what would influence them to pursue or not pursue dietetics as a career. Design: Researchers developed an electronic survey asking about youth’s perceptions of the dietetics profession. Setting/Participants: The survey was distributed to a diverse population of youth aged 14-17 in the USA. Main Outcome Measures: Researchers aimed to understand what qualities 14-17-year-olds associate with dietetics professionals and if youth are interested in and/or view themselves as capable of becoming a dietitian. Analysis: SPSS software calculated descriptive statistics. Open-ended responses were analyzed using conventional content analysis. Results: Half …

One Center's Experience Of Pulmonary Embolism After Covid-19: Impact Of Vaccination Status, Cara Gose, Kaylee Dixon, Andrea M. Bodine Md

Advances in Clinical Medical Research and Healthcare Delivery

Background: The incidence of pulmonary embolism (PE) has increased since the outbreak of the COVID-19 pandemic and may be due to the observed hypercoagulable state. There is conflicting evidence that thromboembolism risk increases after vaccination and that vaccines decrease the probability of having a thromboembolic event. This study aimed to explore how vaccination status impacts occurrence of PE after a positive COVID-19 test. The hypothesis was that vaccinated, immunocompetent patients have a lower incidence of PE after COVID-19 compared to unvaccinated patients.

Methods: This was a retrospective chart review at a teaching hospital in New England from 1/01/2021 to 3/31/2023 …

Enfortumab Vedotin Induced Cutaneous Manifestations, Zeni Kharel, Farhan S. Imran

Advances in Clinical Medical Research and Healthcare Delivery

Enfortumab vedotin(EV) comprises of an anti–nectin-4 monoclonal antibody bound to the chemotherapeutic agent called monomethyl auristatin E, forming an antibody-drug conjugate. It is currently approved for the treatment of locally advanced or metastatic urothelial carcinoma after disease progression on two prior lines of therapy including chemotherapy and immunotherapy. Since nectin-4 is also expressed on the surface of keratinocytes, cutaneous adverse effects are common. Our clinical image depicts a cutaneous adverse reaction to EV and its resolution after discontinuation of EV.