Digital Commons Network^™

Analysis Of Mapt On Alzheimer’S Disease, Elaine Vanterpool

Student Posters

There are multiple factors that contribute to the onset of Alzheimer’s disease. These include genetic causes, environmental factors, and lifestyle choices. Microtubule-Associated Protein Tau. (MAPT) is a gene that is associated with the onset of Alzheimer’s disease. There are 2 main alleles of the APOE gene: H1 haplotype and H2 haplotype. H1 haplotype is the more common variant and is associated with an increased risk of developing tau-related neurodegenerative diseases.H2 haplotype is less common and is thought to have originated from an ancient inversion on chromosome 17q21. It may have some protective effects against certain tauopathies. The H1 haplotype is …

An Analysis Of Htt Involvement In Huntington’S Disease, Elaine Vanterpool, Micah Andrews

Student Posters

Huntington’s disease is a neurodegenerative disorder which affects every three to seven out of 100,000 individuals. Huntington’s is categorized by behavior change, such as reward perception, motivation, decision making, self perception, and struggle with interpersonal skills. Personality change, such as isolation, anxiety, and depression are also commonly seen in cases of Huntington’s. Even though dietary restrictions and physical exercise can slow the progression of Huntingtons, stress has shown to significantly contribute to the manifestation of Huntingtons disease. •Huntington’s disease is a genetic disorder causing atrophy of the brain over time, more specifically cortical and subcortical gray matter. •Most impacted by …

Analysis Of Mutations Of Hydin Gene Associated With Hypertension, Elaine Vanterpool, Savania Simms

Student Posters

Hypertension also called “High Blood Pressure” is a disorder caused by factors such as old age, genetics, weight, physical activeness, and diet. Today hypertension affects 1.28 billion adults aged 30–79 years worldwide (Mayo Clinic, 2024). When hypertension is in the range of 180/120 it can cause symptoms such as headache, chest pain, dizziness, blurred vision, and other symptoms . It is important to study the genes associated with this disorder because it helps to identify what genetic risk factors cause this as well as it helps develop more treatments for it. The gene HYDIN associated with hypertension has 51 variants …

Characterization Of Tnsalp Expression And Activity In Porcine Utero-Placental Tissues, Claire Stenhouse, Nirvay Sah, Katherine M. Halloran, Robyn M. Moses, Makenzie G. Newton, Joe W. Cain, Heewon Seo, Guoyao Wu, Gregory A. Johnson, Fuller W. Bazer

Animal and Food Sciences Faculty Publications

Abstract: Tissue non-specific alkaline phosphatase (TNSALP) regulates postnatal phosphate homeostasis, but its role in utero-placental phosphate availability remains poorly understood. Gilts were bred and hysterectomized on Day 60 or Day 90 of gestation (n = 6/day). Phosphate was less abundant in allantoic and amniotic fluids on Day 90 compared to Day 60. TNSALP protein was immunolocalized, and enzymatic activity was quantified and localized in endometrial and chorioallantois tissues. Day had no effect on TNSALP activity in the chorioallantois. In contrast, endometrial TNSALP activity was lower on Day 90 compared to Day 60. Phosphate abundance in allantoic fluid correlated positively with …

Estimating Proximity To Failure Using Repetitions In Reserve In Adults Treated For Cancer, Kylah Elizabeth Jackson

Theses and Dissertations

BACKGROUND: There is a consensus from governing bodies that more evidence is needed in understanding how to properly prescribe, monitor and progress resistance training (RT) in oncology populations. Repetitions in reserve (RIR) has been demonstrated as a quick/easy tool to monitor proximity to failure and interventions using RIR have shown promise in improving muscle strength and mass in older adults and apparently healthy populations. However, the validity of RIR in RT in oncology has yet to be examined. Therefore, the purpose of this study was to assess the accuracy of RIR predications in individuals treated for cancer in a pragmatic …

Use Of Electrical Household Appliances And Risk Of All Types Of Tumours: A Case-Control Study, Shabana Noori, Abdul Aleem, Imrana Niaz Sultan, Afrasiab Khan Tareen, Hayat Ullah, Muhammad Waseem Khan

Biological Engineering Student Research

Introduction: The use of electrical appliances using extremely low frequency (ELF) electromagnetic fields (EMF) has increased in the past few years. These ELF MF are reported to be linked to several adverse health effects. However, only a couple of studies have been conducted on the association between risk of tumours and use of electronic devices using low frequency (LF) EMF. Methods: We studied the use of common household electrical appliances and suspected risk of tumours in a multi-hospital-based case-control study. In total, 316 patients were included in the final analysis. Results: The study results showed a below unity risk for …

The Impact Of Small-Scale Conflicts On Post-Soviet Alliances, Ani Hakobyan

Journal of Strategic Security

Military alliances are crucial for international and regional security. However, conflicts may disrupt these connections, weakening alliance structures, particularly in complex regions such as the post-Soviet space. This article examines the effects of small-scale conflicts on the post-Soviet alliance network by analyzing the impact of three conflicts: the 2008 Russo-Georgian War, Russia's 2014 annexation of Crimea, and the 2020 Nagorno-Karabakh (Artsakh) War. Using the temporal exponential random graph model (TERGM), the study finds that three conflicts significantly weakened alliance structures in the region, reducing the likelihood of new alliance ties within both the Collective Security Treaty Organization (CSTO) and broader …

American Extremism: An Evolutionary Process, Christopher Young, Michael Damian Tucker

Journal of Strategic Security

This article critically examines the historical definitions of American right-wing extremism as utilized by the media, political community, academia, and the government. We suggest that the historical definitions of the right wing are inadequate and fail to describe extremism accurately and consistently. Using evolutionary game theory, this article further argues that right-wing extremism (and left wing) is based on an evolutionary process to secure social existence and will rise as predators challenge historical hierarchical systems.

The Contribution Of Individual Movements To The Learning Of A Movement Sequence, Hannah K. Ammons

Senior Theses

This thesis explores how the overall learning of a motor sequence through repeated practice is impacted by the individual movement’s components. Changes seen in the response time, peak velocity, and the hand path distance were examined whilst considering the Fitts’s ID and inertial demands of the individual movements. During data collection, twenty-four right-handed participants completed a series of repeated and random reaching movements that varied in direction and distance in a 3D virtual environment. When considering only the repeated sequences, the results indicated significant improvement in both the hand path distance and response time across all target combos, specifically Target …

The Pharmaceutical Applications Of Poisonous Compounds Found In Datura Stramonium, Ruby M. Raffaldt

Senior Theses

Datura stramonium is a plant that is known for its toxicity. However, a facet of this plant’s noxious chemicals, namely its tropane alkaloids, can be used medicinally. The aim of this paper was to compile knowledge on the botanical, chemical, and medicinal properties of Datura stramonium L with a focus on atropine, scopolamine, and anisodamine; three tropane alkaloid compounds with the ability to be both a poison and a medicine. Information was compiled using pre-existing studies, articles, and literature reviews on D. stramonium. For each of the three alkaloids, their biosynthetic pathways, targets, administration, distribution, metabolism, and excretion were discussed. …

Silver Nanoparticles And Vanillin Can Inhibit Collagenase Activities Of Serratia Marcescens, Elaine Vanterpool, Mya St. Louis, Josel Bryant, Kennedi Ewan, Taylor Hall, Leah Marcelle, Mayah Seal

Student Posters

Serratia marcescens is a gram-negative, disease-causing agent that belongs to the Enterobacteriaceae family. This rod-shaped microbe causes many infectious diseases such as urinary and respiratory infections, wound infections, and peritonitis, which can result in fatal bacteremia. Collagenase is an enzyme that breaks down collagen, while also playing a key role in the extracellular matrix. Collagenase uses zinc to operate that helps it break down the peptide bonds in collagen. Testing Agents ❖ Metronidazole is an antimicrobial drug used to treat infections caused by different anaerobic bacteria, such as infections in the blood, liver, bones, joints, and meninges. ❖ Vanillin is …

Silver Nanoparticles And Natural Compounds Can Modulate Proteolytic Activities Of Escherichia Coli, Elaine Vanterpool, Simone Chotan, Wendolyn Johnson, Emilee Duany, Antonio Ward

Student Posters

Investigating the impact of antibacterial agents on Escherichia coli (E. coli) protease activity is vital for advancing new approaches to combat bacterial infections. Proteases are crucial enzymes in bacterial physiology that contribute to immune system evasion, biofilm development, and host tissue degradation. Due to these enzymes being directly involved in E. coli virulence, understanding how antibacterial compounds affect protease function may lead to innovative treatment strategies. E. coli is a gram-negative, facultatively anaerobic bacterium that exists both as a harmless intestinal commensal and a significant human pathogen. Many lives have been negatively affected by severe E. coli infections in the …

Analyzing The Inhibition Of Chemical Compounds On Protease In P. Aeruginosa, Elaine Vanterpool, Micah Andrews, Marielle Cooper, Mitspah Eshette, Anaya Moodie-Lee, Jayda Russell, Jordon Vanterpool

Student Posters

Pseudomonas aeruginosa is a gram-negative, bacillus-shaped opportunistic pathogen, notorious for invading immunocompromised individual leading to secondary infections. These opportunistic microbes typically are implicated mild to more severe infections including burn or wound infections to more serious systemic infections. The bacterium Ps. aeruginosa utilizes a variety of virulence factors to enhance the pathogenicity of the organism. Virulence factors secreted by Ps. aeruginosa include its pili, adhesins, capsule, exotoxin A, and lipopolysaccharide (LPS). The proteases produced by Ps. aeruginosa are powerful virulence factors that can lead to tissue destruction and immune invasion. It is imperative that we find ways of regulating the …

Improving Biocompatibility And Structural Integrity Of Decellularized Biomaterials, Elaine Vanterpool, Jayden Vanterpool, Ayanna Liburd, Andrew Mcintosh, Cayden Pyform, Cameron Scott, Jea Joseph Msie

Student Posters

Venous grafting using synthetic and biomaterials has been one of the forefront issues of the scientific community. For years, in vitro experimentation of both bio and synthetic materials has been carried out with the hope of treating issues like chronic venous insufficiency, heart attacks, artery blockage, etc. Within these issues, there has been much success. Numerous cases have made it to clinical trials with grafts lasting as long as two years within the patient. Nonetheless, some common and persistent issues occur within all the cases observed. Despite extensive experimentation and development of the most prestigious technology, thrombosis, negative immune response, …

The Influence Of Mef2c Variants On Autism Development, Elaine Vanterpool, Maya O'Reilly

Student Posters

MEF2C (Myocyte Enhancer Factor 2C) is a gene that is important for brain development and function, especially in neurons that help transmit signals across the brain. It is crucial for learning, memory, and movement. Mutations in the MEF2C gene can lead to MEF2C-related disorder, a neurodevelopmental condition that causes developmental delays, intellectual disabilities, low muscle tone, seizures, and behaviors often associated with autism. People with this disorder may also experience speech difficulties, sleep problems, vision issues, and heart complications. About half of those affected by MEF2C related disorder may not be able to walk independently due to motor skill issues. …

Using Secreted Biomarkers In The Development Of The Detection Of Advanced Cancer Screening System, Elaine Vanterpool, Jaydan Vanterpool, Jordon Vanterpool, Robert Lister, Shania Swain, Enock Ngoga, Jovaughn Redley, Imani Shields, Dalen Jones, Santiago Moreno, Ronnie Nichalson, Jea Joseph Msie

Student Posters

As of 2020, there were an estimated 19.3 million new cancer cases and almost 10 million cancer deaths. Among the different types of cancers in the world, the most prevalent cancer, lung cancer, accounted for 23% of all cancer deaths (CDC) and has been relatively steady since 1999. However, by using Detection of Advanced Cancer Screening (D.A.C.S), many patients with cancer cases would receive efficient, reliable treatment in a timely manner. According to Cancer.gov, multiple participants reported being screened for cancer, “After they had ‘aged out of the recommended range for routine cancer screening”. (Dr. Moss) “We found that over …

Mutations In The Pms1 Gene Associating With Ovarian Cancer, Elaine Vanterpool, Erin Hough

Student Posters

Ovarian cancer occurs when abnormal cells in the ovaries grow and divide uncontrollably, destroying healthy body tissue. Common symptoms of ovarian cancer include weight loss, fatigue, discomfort in the pelvic area, or changes in bowel habits. This study focuses on how ovarian cancer is related to the PMS1 gene. The PMS1 gene encodes MLH1, a protein involved in DNA mismatch repair (MMR) system. MMR helps connect errors that occur during DNA replication, preventing mutations and potential cancer development. When this gene is mutated, there is an increased risk of developing ovarian and other endometrial cancer. Bioinformaic softwares allow us to …

The Effect Of Grape Seed Extract Against The Formation Of S.Aureus Biofilms In A Clinical Setting, Srestha Samaddar

Senior Theses

The rise of antibiotic-resistant bacterial infections, particularly those caused by Staphylococcus aureus, poses a serious threat to public health and clinical care. A major contributor to the persistence of these infections is the formation of bacterial biofilms, structured communities that protect S. aureus from antibiotics and immune responses, especially on surgical sites and medical devices. As conventional treatments become less effective, interest in alternative, natural antimicrobial agents has increased, due to public dissatisfaction with conventional medicine and a growing trust in complementary and alternative medicine. Grape seed extract (GSE), a polyphenol-rich byproduct of winemaking, has emerged as a promising candidate …

Impact Of Msx1 And Irf6 Gene Variants On Orofacial Cleft And Facial Development, Elaine Vanterpool, Lisa Banks

Student Posters

A cleft lip or palate is a congenital anomaly that occurs when a baby's mouth doesn’t form properly during pregnancy. It happens when the tissues that shape the upper lip or roof of the mouth fail to join during development. It is among the most common birth defects associated with genetic conditions or syndromes. Orofacial cleft can be caused by a combination of genes and other factors like the mother's exposure to environmental things, diet, and medications during pregnancy. Examining the genes involved and making connections that provide insight into the improper formations of the maxillary tissues during fetal stages …

Effects Of Cell-Free Supernatants Of Commercial Yogurt Products On Salmonella Survival, Juliet Durant, Akayla King

Student Posters

Salmonellosis remains a global public health challenge and Salmonella enterica serovar Enteritidis and Typhimurium are the primary causes. Salmonella virulence mechanisms involve attachment and invasion of intestinal epithelial cells. Gut microbiota and probiotics that contain Lactobacillus species have been shown to prevent Salmonella infection. Yogurt is a commonly consumed probiotic product containing Lactobacillus species. Yogurts made under laboratory conditions and the cell-free supernatants have been shown to inhibit Salmonella growth. The many commercial yogurt products on the market may vary in antimicrobial components based on production methods. Therefore, the present study aimed to evaluate the survival of 5 log CFU/mL …

Title: An Analysis Of Hmbs Variants Associated With Acute Intermittent Porphyria, Elaine Vanterpool, Jason Kahari

Student Posters

HMBS, also known as hydroxymethylbilane synthase, is a gene that is responsible for providing instructions for making the enzyme named hydroxymethylbilane synthase. This enzyme is involved in the creation of a molecule called heme. Heme plays an important part in all of the body’s vital organs. It is important to all organs however, it is most prevalent in the blood, bone marrow, and liver. Heme is essential in making iron-containing proteins called hemeproteins. To produce heme, an eight-step process must occur that requires 8 different enzymes. “Hydroxymethylbilane synthase is responsible for the third step in this process, which combines four …

The Association Of Abca3 Variants In Hypertension Pathogenesis, Elaine Vanterpool, Jea Joseph

Student Posters

Hypertension affects around 48.1% of people living in the United States. This number of adults with hypertension between the ages of 30-70 has increased from 650 million to 1.28 billion in the last 30 years. Hypertension is characterized as a condition that affects the arteries of the blood. High blood pressure and high cholesterol have a huge correlation to each other. When the body cannot rid cholesterol from the blood stream, it can deposit along artery walls and clog them, making blood flow harder and increases blood pressure. ABCA3 is a member of the ATP binding cassette family of proteins …

An Analysis Of Oas1 Variants Associated In Diabetes Mellitus, Elaine Vanterpool, Ashley Tannis

Student Posters

Type 1 diabetes is caused by a combination of multiple genetic and environmental factors that precipitate autoimmune destruction of the insulin-producing β-cells of the pancreas. Individuals with type 1 diabetes have higher frequencies of OAS1 GG and GA genotypes than nondiabetic's.OAS1, an interferon-induced gene, also known by its official name, 2'-5'-oligoadenylate synthetase 1, encodes proteins that play a crucial role in innate cellular antiviral response which prevents viral replication by activating the adaptive immune system to erase the virus trying to spread. OAS1 is also involved in additional cellular processes such as cell growth and cell death. This gene is …

Cryo-Em Captures The Coordination Of Asymmetric Electron Transfer Through A Di-Copper Site In Dpor, Rajnandani Kashyap, Natalie Walsh, Jaigeeth Deveryshetty, Monika Tokmina-Lukaszewska, Kewei Zhao, Yunqiao J. Gan, Brian M. Hoffman, Ritimukta Sarangi, Brian Bothner, Brian Bennett, Edwin Antony

Physics Faculty Research and Publications

Enzymes that catalyze long-range electron transfer (ET) reactions often function as higher order complexes that possess two structurally symmetrical halves. The functional advantages for such an architecture remain a mystery. Using cryoelectron microscopy we capture snapshots of the nitrogenase-like dark-operative protochlorophyllide oxidoreductase (DPOR) during substrate binding and turnover. DPOR catalyzes reduction of the C17 = C18 double bond in protochlorophyllide during the dark chlorophyll biosynthetic pathway. DPOR is composed of electron donor (L-protein) and acceptor (NB-protein) component proteins that transiently form a complex in the presence of ATP to facilitate ET. NB-protein is an α2β2 heterotetramer with two structurally identical …

Protecting The Freedom Of Movement For All: A Proposal For Complete Street Policies That Prioritize The Needs Of Travelers With Idds And Autism In The Wake Of N.J. Bill S147, Olivia Handelman

Cardozo Journal of Equal Rights & Social Justice

The note examines the groundbreaking implications of New Jersey Bill S147, which mandates the New Jersey Department of Transportation (NJDOT) to develop complete street designs specifically addressing the needs of individuals with intellectual and developmental disabilities (IDD) and Autism Spectrum Disorder (autism). This legislation represents a significant shift in complete streets policies, which traditionally focus on physical accessibility but rarely prioritize non-physical disabilities. The note argues that NJDOT’s implementation of these designs must include tailored strategies, such as mobility education, staff training, and improved signage, to ensure independent and safe travel for this population. By addressing these needs, New Jersey …

Lincolnville Old Jail, Frank Ordia, Craig Bennett, Amalia Leifeste, Jessica Ridder, Samantha Threlkeld, Jessica Stech, Alexandra Ullman, Ashton Steele, Summer Henry, Belle Ziethen, Hamzah Jule, Lorena Garrod, Zenic Rice, Jackson Dent, Thompson Teasdale, Thomas A. Darrah

Master of Science degree in Historic Preservation - Research Reports

The following report provides documentation of the Lincolnville Old Jail, located at 135 W Smith Street in the town of Lincolnville, South Carolina. It was completed by the students of Clemson University’s Graduate Program in Historic Preservation during their Preservation Studio class, led by professors Amalia Leifeste and Frank Ordia, along with Teaching Assistants Hannah Truman and Jessica Ridder, provided additional support in the generation of the final report.

In the months of January and February of 2025, students completed a set of drawings of the old jail to Historical American Building Survey (HABS) standards, supplemented by historical research, and …

Traumatic Brain Injury And Substance Use Disorder: A Clinic Based Exploratory Study, Steven Daniel Wheeler, Amanda Acord-Vira, Cecelia Simons, Kaleigh Papez, Jeremy Dixon, Cortland Nesley

Graduate Student Scholarship

Background: Traumatic brain injury (TBI) and substance use disorders (SUD) are common co-occurring conditions that have been investigated in isolation over the past several decades. Research regarding the conditions in unison have yielded conflicting results; however, there is a clear correlation linking negative implications of one condition on the other.

Objectives: To explore factors contributing to SUD among persons screening positive for a history of TBI and to validate the importance of screening for TBI as part of the SUD treatment program intake process.

Setting: Outpatient SUD treatment programs across West Virginia.

Design: Exploratory Study.

Methods: Those who screened positive …

Evaluating The Human Abuse Potential Of Concurrent Use Of Electronic Cigarettes And Low Nicotine Cigarettes Among Adults Who Smoke, Jason D Robinson, Yong Cui, George Kypriotakis, Jeffrey M Engelmann, Maher Karam-Hage, Jennifer A Minnix, Charles E Green, Sanjay Shete, Dorothy K Hatsukami, Eric C Donny, Sharon E Murphy, Stephen S Hecht, Thomas Eissenberg, David W Wetter, Paul M Cinciripini

Faculty, Staff and Student Publications

The U.S. Food and Drug Administration has stated its intention to reduce the nicotine content of combustible cigarettes to render them less addictive. This study evaluated the impact of providing adults who smoke with both very low nicotine content cigarettes (VLNCCs) and electronic cigarettes (ECs) of varying nicotine content on measures of human abuse potential. Participants (

Harnessing Knowledge And Data For Clinical Information Extraction In The Era Of Large Language Models, Yan Hu

Dissertations and Theses (Open Access)

The rapid digitization of healthcare records has led to the widespread adoption of Electronic Health Records (EHRs), which contain rich, unstructured clinical notes. These notes hold valuable information for patient care and clinical research, but their complexity and unstructured nature pose significant challenges for effective utilization. Clinical Information Extraction (IE) aims to bridge this gap by transforming unstructured text into structured data, enabling automated analysis. Traditional Natural Language Processing (NLP) techniques, such as Named Entity Recognition (NER), have been widely used for clinical IE, but recent advancements in Large Language Models (LLMs) like GPT-3.5, GPT-4, and LLaMA have opened new …

Leveraging And Advancing The Foundation Models For Clinical Trajectory Analysis Based On Electronic Health Record Data, Jianping He

Dissertations and Theses (Open Access)

Enhancements in foundation models have provided significant potentials for clinical applications. This dissertation leverages and advances foundation models for a range of clinical tasks using electronic health record (EHR) data, demonstrating their applicability in Clinical Temporal Relation Extraction (CTRE), disease prediction, and patients trajectory analysis.

Aim 1 is to efficiently adapt large language models (LLMs) for CTRE in both full data and few-shot settings. This study leveraged four LLMs: GatorTron-Base, GatorTron-Large, LLaMA3.1, and MeLLaMA. The proposed fine-tuning strategies include: (a) standard fine-tuning; (b) hard-prompting; (c) soft-prompting; (d) Low-Rank Adaptation (LoRA). We found that nearly all proposed fine-tuning strategies outperformed existing …