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Brain–Computer Interface Integration In Mental Health: Clinician Perspectives On Diagnostic Efficacy And Ethical Implications, Serena D. Sanders

Walden Dissertations and Doctoral Studies

This study explored the integration of brain–computer interface (BCI) technology into mental health care, focusing on clinicians' perceptions, ethical concerns, and the practical challenges associated with its adoption. As technological advancements in healthcare continue to reshape clinical practices, understanding how emerging technologies like BCI can be incorporated into therapeutic settings is essential. The purpose of this research was to examine clinician perspectives on the potential benefits of and barriers to BCI and to explore the ethical implications of its use in therapy. Guided by the technology acceptance model and the ethical decision-making framework, this qualitative study utilized semi structured interviews …

Tuning Switch Performance For Single Molecule Electronics, Elaina I. Grogg

Longwood Senior Theses

In the field of single molecule electronics, chemical principles can be used to design molecules that are incorporated into metal-molecule-metal electronic junctions. Computational chemistry has been used to investigate changes in the performance of a single molecule switch. Changes in the on/off ratio of photoswitches due to the addition of electron-donating and electron-withdrawing substituents were observed. In many cases, the electrodes and electrode-molecule coupling have a more pronounced effect on the performance of the junction than other modifications within the molecule at the core of the junction. Chemical modifications on the molecular switch are used to demonstrate the ability to …

Structural Basis Of Panx1 Permeation And Positive Modulation By Mefloquine, Yangyang Li, Zheng Ruan, Junuk Lee, Ian Orozco, Edward Zhou, Juan Du, Wei Lü

Department of Biochemistry and Molecular Biology Faculty Papers

Purinergic signaling relies on ATP release through exocytosis and large-pore channels. Large-pore channels permeate both small anions like chloride and large signaling molecules like ATP, but how this broad cargo selectivity is structurally controlled remains elusive. Here we investigate PANX1, a prototypical large-pore channel, and uncover structural plasticity at the extracellular entrance formed by seven tryptophan (W74) residues. The W74 sidechains are flexible, sampling conformations that range from a constricted state permissive only to chloride to a dilated state compatible with ATP. These states are coupled to variable cation-π interactions between W74 and arginine 75 (R75), suggesting a mechanism for …

First-In-Child Phase I Trial Of P-Stat3 Inhibitor Wp1066 In Pediatric Brain Tumor Patients, Robert C Castellino, Hope L Mumme, Andrea T Franson, Bing Yu, M Hope Robinson, Kavita Dhodapkar, Dolly Aguilera, Matthew J Schniederjan, Rohali Keesari, Zhulin He, Manoj Bhasin, Waldemar Priebe, Amy B Heimberger, Tobey J Macdonald

Faculty, Staff and Student Publications

Background: WP1066 is an orally bioavailable, small molecule inhibitor of activated p-STAT3 that has demonstrated preclinical efficacy in pediatric brain tumor models.

Methods: In a first-in-child, single-center, single-arm 3+3 design Phase I clinical trial, ten patients were treated with WP1066 twice daily, Monday-Wednesday-Friday, for 14 days of each 28-day cycle to determine the maximum tolerated dose (MTD)/maximum feasible dose (MFD) of WP1066. Compassionate use treatment with WP1066 in three pediatric patients with H3.3 G34R/V-mutant high-grade glioma (HGG) is also described.

Results: There was no significant toxicity and the MFD was determined to be 8 mg/kg. Treatment-related adverse events were Grade …

Role Of Cellular Stress Responses In Innate Immune Defense Against Acute Respiratory Infections, Amit Sharma

LSU Doctoral Dissertations

The endoplasmic reticulum (ER) stress sensor inositol-requiring enzyme 1α (IRE1α) is an important regulator of innate immune cells. However, its role in pulmonary innate host defenses remains poorly understood. This dissertation elucidates the dual, context-dependent role of IRE1α in host defense against methicillin-resistant Staphylococcus aureus (MRSA) pneumonia. We demonstrate IRE1α’s function as both a detrimental mediator of acute pathology and an essential facilitator of innate immune memory. Our work revealed that acute IRE1α activation during primary MRSA infection is detrimental. In lungs and alveolar macrophages (AMs), IRE1α is activated in response to MRSA infection. Consequently, IRE1α activation triggers a hyperinflammatory …

Biosynthesis, Characterization Of Curcumin-Capped Zno-Cuo And Chitosan-Curcumin-Capped Zno-Cuo Based Omaterial As Antibacterial Agent Of Escherichia Coli, Ahmad Fatoni, Afnita Fatmawati Umli, Reza Agung Sriwijaya, Hilma Hilma, Nurlisa Hidayati

Chimica et Natura Acta

The biofabrication of the chitosan-curcumin-capped ZnO-CuO and curcumin-capped ZnO-CuO oparticles, as well as their ability to combat Escherichia coli bacteria, were the focus of this study. Fourier-Transform Infrared (FTIR) spectroscopy, X-ray diffraction (XRD), and Scanning Electron Microscopy (SEM) were used to examine the chitosan-curcumin-capped ZnO-CuO and curcumin-capped ZnO-CuO oparticles, respectively. Both were evaluated using the agar diffusion method as antibacterials against Escherichia coli. Results of analysis with FTIR, between 500 and 700 cm⁻¹, the functional group of Cu-O or Zn-O was seen at its highest point. The functional group of Cu-O and Zn-O in curcumin-capped ZnO-CuO was detected at wavenumber …

A Functional Mri Meta-Analysis Encoding In Alzheimer’S Disease, Joanne Ha

Master's Theses

Alzheimer’s disease (AD) is the most common form of dementia and is characterized by episodic memory impairment. Numerous functional magnetic resonance imaging (fMRI) studies have examined brain activity differences between individuals with AD and age-matched controls during memory encoding. However, small sample sizes and methodological variability across studies have limited the ability to draw meaningful conclusions regarding brain activity underlying encoding impairments. We conducted a meta-analysis to identify consistent patterns of hyperactivity and hypoactivity in AD during episodic memory encoding. Using PubMed to identify studies that met our inclusion criteria, 1,002 studies were screened; ultimately, seven studies were included in …

Evaluation Of Internal Field In Ppln And Studies On Qpm Shg Efficiency Factor, Prasath Rk Mr

Theses and Dissertations

Periodically Poled Lithium Niobate (PPLN) crystals have attracted interest in optoelectronics and nonlinear optics. The response to the applied electric field is determined by their larger electro-optic and nonlinear optical coefficients. An internal electric field exists in congruent PPLN crystals due to its defects. Its evaluation is important in controlling the electro-optical behavior. A simple nondestructive diffraction method is proposed to estimate the internal electric field present in the congruent lithium niobate crystal.

Due to the presence of an unrelaxed internal field, the as-poled sample acts as an index grating. When a light is incident on such a sample, it …

Assessing The Association Between Covid-19 Vaccination And Thrombotic Thrombocytopenia Syndrome (Attest Study): Analyses Of English Data, 2020-2022, Jose Ordonez-Mena, Xinchun Gu, Mark Joy, Xuejuan Fan, Bernardo Meza-Torres, William Hinton, Rashmi Wimalaratna, Gavin Jamie, Anna Forbes, Debasish Kar, Rachel Byford, Sneha N. Anand, Filipa Ferreira, Lisa Mather, Andrew Lee, F. D. Richard Hobbs, Deborah Layton, Simon De Lusignan

Peninsula Medical School

ObjectiveCOVID-19 vaccine surveillance detected thrombotic thrombocytopenia syndrome (TTS), a rare combination of thrombosis and thrombocytopenia, after COVID-19 vaccination. We evaluated TTS risk within 28 days of AZD1222 and BNT162b2 exposure.MethodsMatched case-control (MCCS) and self-controlled case series (SCCS) studies used Oxford-Royal College of General Practitioners Research and Surveillance Centre data linked to immunisation, hospitalisation and death data. English patient records extracted from 2/12/2020 to 31/10/2022 were used to identify TTS cases and age, sex, and practice matched controls. Conditional logistic regression and conditional Poisson regression were used for MCCS and SCCS analyses, respectively.ResultsOf 666 TTS events identified, >90% happened without AZD1222/BNT162b2 …

Atypical Spindle Cell Lipomatous Tumor: A Scoping Review Of Current Insights Into Diagnosis, Pathogenesis, And Management, Noor Chughtai, Jordan Shelestak, Cortland Brown, Jared Nichols

Student Publications

Atypical spindle cell/pleomorphic lipomatous tumor (ASPLT) is a recently recognized benign adipocytic neoplasm, distinguished by specific histopathological and immunohistochemical features. Although traditionally classified as a tumor of the limbs and limb girdles, emerging evidence suggests a broader anatomic distribution. A systematic review of the literature was conducted using PubMed to identify ASPLT case reports published within the past decade. Cases were included if they had a confirmed ASPLT diagnosis, while reports describing unrelated neoplasms or limited by language barriers were excluded. Thirteen cases met the inclusion criteria. Data on patient demographics, tumor characteristics, immunohistochemical profiles, and diagnostic methodologies were extracted …

Core And Characteristic Oral Microorganisms In The Giant Pandas (Ailuropoda Melanoleuca) Suggested Plenty Of Antibiotic Resistance Prevalence: A Mini Review, Han Long, Haifeng Liu, Caiwu Li, Xiaoping Ma, Guangneng Peng, Zhijun Zhong, Chengdong Wang, Ziyao Zhou

The Thai Journal of Veterinary Medicine

The giant panda (Ailuropoda melanoleuca) is a world-recognized rare wildlife endemic to China. Oral microorganisms may cause dental and other systemic diseases. Additionally, antibiotic resistance in this cute mammal may spread widely to travelers. In this mini review, we illustrated the oral core microorganisms of the giant pandas and their characteristics, as well as their prevalence of antibiotic resistance genes. Although there is limited availability in panda sample collection, researchers have made great efforts to find the characteristics of the giant pandas’ oral microbiota, including Enterococcus faecium, Enterococcus faecalis, and Staphylococci, with antibiotic resistance genes optrA …

Sir Sultan Mahomed Shah Aga Khan Iii - One Of Muslim World's Most Visionary And Influential Leaders

University anniversary celebration materials

No abstract provided.

The Chemistry Of Color: A Comparative Analysis Of Natural And Synthetic Dyes In Textile Application, Caitlyn Pinaga Cpht

Honors Program Theses and Research Projects

The Chemistry of Color: A Comparative Analysis of Natural and Synthetic Dyes in Textile Application examines how color functions at the intersection of chemistry, culture, and environmental responsibility. This project traces the evolution of dyeing from ancient natural pigment traditions, rooted in ecological knowledge, agricultural practices, and cultural identity, to the industrial rise of synthetic dyes, whose laboratory precision enabled unprecedented consistency, brightness, and global textile expansion. Through experimental swatch analysis, the study compares the behavior of natural dyes derived from plants and food sources with modern fiber-reactive and synthetic dye classes on a range of fibers including cotton, bamboo …

Development Of Microcrystalline Tests For Fentanyl, Clonazepam, And Diazepam Identification, Karis French

Honors Projects

Microcrystalline tests are chemical tests that involve the mixing of a substance with a specific reagent resulting in the formation of a crystal structure. Currently, microcrystalline tests are used as presumptive tests in forensic drug chemistry laboratories to provide the suspected identity of unknown substances. There is, however, a limited amount of research on this use of microcrystalline structures. Additionally, this existing research is outdated and does not include some of the newer commonly encountered controlled substances including fentanyl, clonazepam, and diazepam. This literature-based review attempts to identify reagents that could be used in microcrystalline tests for the identification of …

Social Media Use And Its Association With Eating-Related Attitudes And Behaviors In Rural University Students, Erin S. Clark

Honors College Theses

Context: Eating disorders (EDs) are psychiatric illnesses wherein atypical patterns of eating induce harmful physical and psychosocial consequences. ED rates have increased globally in recent years, jumping from an estimated 3.5% to 7.8% between 2006 and 2018. ED onset typically occurs in adolescence and early adulthood and results from complex interactions between biological, psychological, and social factors. One such social factor is social media (SM) usage.

Research Design: The present quantitative study examines how measures of SM use (including use intensity, activity, personal perceptions of SM, and initial age of introduction to SM) relate to ED risk among rural university …

2025-12 December Newsletter, Sammi Williams

NMOER Newsletters

No abstract provided.

Understanding The Physiological Mechanisms Of Thermal Tolerance In Three Reef-Bulding Species Of Coral, Rachel Mccarty

Honors Capstone Projects and Theses

No abstract provided.

Bridging The Rural Justice Gap: A Scalable Solution Rooted In Clinical Legal Education, Michelle Paxton

Northwestern Journal of Law & Social Policy

The rural justice gap significantly impacts child welfare legal representation, exacerbating the challenges families face when navigating juvenile courts in rural America. Attorneys in these communities frequently encounter geographic isolation, limited access to specialized training, professional burnout, and inadequate resources, all of which hinder effective advocacy for vulnerable children and families.

This article argues that clinical legal education, when paired with structured post-graduate training and multidisciplinary consultation, offers a replicable model for addressing the rural attorney shortages in juvenile court advocacy. The Nebraska Children’s Justice and Legal Advocacy Center (NCJC) illustrates how this model can be designed and scaled to …

Disentangling Complex Relationships And Disjunctions In Western Camassia: Integrating Multiple Criteria To Resolve Taxonomic Boundaries, Susan R. Kephart, Theresa M. Culley, Jenny K. Archibald, Robert Tunison, Kathryn E. Theiss, James E. Kephart

Michigan Tech Publications

Premise: Understanding genetic and morphological variability helps efforts to sustain landscapes and develop effective species concepts for resolving difficult groups. To unravel puzzling relationships and range disjunctions, we applied morphometrics, phenology, phylogenetics and population genetics in Camassia species with cultural, ecological, and conservation value, asking: Do the unusual Camassia populations in northeastern California represent previously unrecognized, disjunct C. howellii? Do C. howellii, C. leichtlinii, and C. quamash maintain diagnostic features in allopatry or sympatry? Are C. quamash subsp. breviflora and subsp. linearis taxonomically distinct?. Methods: We evaluated 34 Camassia populations in situ for morphometric traits, phenology, and habitat type, collecting …

High-Resolution Lidar Observations Of Sedimentation-Induced Size Sorting Of Droplets Near A Laboratory Cloud Top, Fan Yang, Yong Meng Sua, Zipei Zheng, Jesse Anderson, Hamed F. Sadi, Jae Min Yeom, Suryadev Pratap Singh, Pei Hou, Will Cantrell, Ernie Lewis, Alex Kostinski, Raymond Shaw

Michigan Tech Publications

No abstract provided.

Review Of Lifespan Development, Esmeralda Rivera

Open Educational Resources - Reviews

No abstract provided.

White Nose Syndrome In Bats And Infant Mortality In Georgia, Rhys Medcalfe, Sean Medcalfe, Simon Medcalfe

Journal of the Georgia Public Health Association

Background: White nose syndrome (WNS) is a disease in bats caused by the fungus Pseudogymnoascus destructans that can result in bat mortality rates of over 90%. WNS was discovered in Georgia in 2012 in 3 counties but has continued to spread to 14 counties as of 2023, with P. destructans detected in a further seven. Biodiversity loss has been linked to human health outcomes including infant mortality. Understanding the link between WNS, biodiversity loss, and infant mortality in Georgia is important because Georgia ranks 42^nd out of the 50 states for infant mortality rate.

Methods: Using panel data from …

Psychiatric Comorbidities And Treatment Modalities In Children With Osteogenesis Imperfecta: A Systematic Review Of Mental Health, Julia M Morales, Camille F Villar, Beatriz Varman, Gianna M Colombo, Danqi Li, Sarah J Sadek, Marie-Eve Robinson, Chaya N Murali, Kara Ayers, Jocelyn Gomez, Brendan Lee, V Reid Sutton, Eric A Storch, Andrew D Wiese

Library Staff Publications

To evaluate the prevalence of psychiatric signs and symptoms and describe psychotherapeutic and psychopharmacological interventions among children with osteogenesis imperfecta (OI). PRISMA guidelines were followed, and the study was registered in PROSPERO (CRD42024588284). Studies (n = 1419) were identified across five databases. Eligible studies, identified by independent reviewers, included peer-reviewed research on psychiatric comorbidities or interventions in children with OI. Data extraction included study design, population characteristics, mental health outcomes, and treatment effectiveness, with all studies assessed for quality and bias. Findings were synthesized to evaluate the prevalence of psychiatric comorbidities and intervention effectiveness. Five articles met inclusion criteria after …

Microplastic Exposure Alters Tubulin Leading To Alterations In Insulin Secretion By Pancreatic Beta Cells, Anakaren Garcia

Honors Program Theses and Research Projects

Abstract

Diabetes mellitus is a metabolic disorder characterized by elevated blood glucose levels due to impaired insulin secretion or diminished cellular response to insulin (resistance). Pancreatic β-cells depend on a well-organized cytoskeleton, particularly microtubules composed of α- and β-tubulin heterodimers, to transport insulin granules to the plasma membrane during glucose-stimulated insulin secretion (GSIS). Disruption of microtubule organization can impair granule trafficking and reduce insulin release. However, emerging environmental toxicants such as microplastics that interfere with β-cell cytoskeletal function remains largely unexplored.

Microplastics (MPs) are small plastic particles (< 5 mm) that have become widespread environmental contaminants and can enter biological systems. Previous studies have shown that MPs can induce cellular stress and protein misfolding, but their effects on microtubules in pancreatic β-cells are not well characterized. This study investigates whether exposure to fluorescent polystyrene microplastics alters microtubule organization and insulin secretion in βTC-6 cells.

βTC-6 cells were treated with 10 µg/mL of fluorescent polystyrene microplastics for …

Ian Colburn, Ian Colburn, Katie Slack

Oral Histories of Farming along the Middle Rio Grande

No abstract provided.

A Sedimentary Source Of Rare Earth Elements In The North Atlantic, Rylee D. Lindner

Electronic Theses and Dissertations

Individually and as a series, the Rare Earth Elements (REEs) are powerful geochemical tracers of environmental processes. However, ambiguities in the oceanic budgets of the REEs hamper their application. Growing evidence suggests a sedimentary benthic flux via the pore water is the major source of REEs to the ocean, with extrapolated estimates of this flux being equivalent in magnitude to that “missing” from modern budgets. However, existing pore water REE data are available from only a few locations globally with no representative dataset from the open North Atlantic. This data scarcity limits our ability to constrain flux estimates and understand …

Healthcare Access, Economic Stability, And Food Security And Inflammatory Bowel Disease In Hispanic Adults Living In The United States, Jennifer Rodriguez

Walden Dissertations and Doctoral Studies

Hispanic adults in the United States experience disparities in chronic disease detection and outcomes, including inflammatory bowel disease (IBD). Social determinants of health (SDoH), including economic stability, healthcare access, and food security, play a crucial role in shaping health risks and diagnostic opportunities in this population. The purpose of this quantitative cross-sectional study was to examine the relationship between selected SDoH factors and self-reported IBD diagnosis among U.S. Hispanic adults. This study utilized survey data from the 2023 National Health Interview Survey (n = 29,457). Weighted descriptive statistics and logistic regression were used to analyze the relationships between variables while …

Midweek Memo, Georgia Southern University

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Expressing Diversity And Anxiety Among Graduate Psychology Students, Paola G. Garcia Betancourt

Walden Dissertations and Doctoral Studies

This quantitative study examined the relationship between motivational factors that contribute to challenges in expressing diversity and the levels of anxiety experienced by graduate psychology students when discussing racial topics. The study was grounded in critical race theory, which posits that racism is embedded within social and institutional systems and influences interpersonal and educational dynamics. The purpose of the study was to determine whether motivational factors, as measured by the Color-Blind Racial Attitudes Scale, predicted anxiety levels, as measured by the Patient-Reported Outcomes Measurement Information System Emotional Distress Anxiety Short Form, and whether racial background moderated this relationship. Data were …

A Canadian Advanced Physiotherapist Practitioner Shared-Care Model In Pediatric Rheumatology Offers Safe And Quality Care In The Management Of Juvenile Idiopathic Arthritis-Comparing Key Performance Indicators With The Pr-Coin Registry., Julie Herrington, Patrick Clarkin, Jade Singleton, Karen Beattie, Sheetal S. Vora, Katelyn Banschbach, Catherine A. Bingham, Tania Cellucci, Danielle Fair, Mileka Gilbert, Beth Gottlieb, Julia G. Harris, Liane Heale, Tzielan Lee, Melissa L. Mannion, Edward J. Oberle, Nancy Pan, Jonathan Park, Mary Toth, Jennifer E. Weiss, Michelle Batthish, Pediatric Rheumatology Care And Outcomes Improvement Network

Manuscripts, Articles, Book Chapters and Other Papers

Background/Objectives: Canadian Advanced Physiotherapist Practitioner (APP) roles have existed for over 25 years in pediatric rheumatology. The APP can manage many common pediatric rheumatic conditions most often in Shared-Care Models (SCMs) with pediatric rheumatologists (PRs). The quality of care children receive in an APP SCM compared to traditional care is unknown. The Pediatric Rheumatology Care and Outcomes Improvement Network (PR-COIN) tracks quality measures as Key Performance Indicators (KPIs) in juvenile idiopathic arthritis (JIA) care. This study aimed to analyze the frequency of KPIs documented in a pediatric rheumatology APP SCM from a single center and compare to PR-COIN's performance …