Digital Commons Network^™

Promoting An Inclusive And Humanised Environment In The Intensive Care Unit: Shift Happens, Emilio Rodriguez-Ruiz, Jos M. Latour, Margo M.C. Van Mol

School of Nursing and Midwifery

No abstract provided.

Quality Of Life Among Indonesian Family Caregivers Caring For Dependent Older Persons With Type 2 Diabetes Mellitus In The Community: A Cross-Sectional, Correlational Study, Rinco Siregar, Charuwan Kritpracha, Tippamas Chinnawong, Jos M. Latour

School of Nursing and Midwifery

Background: The global prevalence of older adults with diabetes has increased, and family caregivers in Indonesia play a critical role in managing diabetes and providing personal care. However, caregiving can be complex and challenging, often negatively affecting caregivers' quality of life (QoL). Objective: This study aimed to develop and test a hypothesized causal model of QoL among Indonesian family caregivers who care for dependent older persons with type 2 diabetes mellitus (T2DM) in 2024. Methods: A cross-sectional, correlational study was conducted with 270 family caregivers recruited from five Community Health Centers. Data were collected using various scales: the Center for …

Tactile Kinaesthetic Methods Without Abdominal Pressure Promoting Gastrointestinal Passage In Preterm Infants: A Scoping Review, Natalie Hurst, Jos M. Latour, Christian F. Poets, Christoph E. Schwarz

School of Nursing and Midwifery

Background: Tactile kinaesthetic stimulation (TKS) might support enteral feeding and meconium excretion in preterm infants, but volvulus has been linked to abdominal massage. Aim: To map the evidence and to identify knowledge gaps on TKS in preterm infants. Methods: A scoping review was conducted in August 2024 using four databases. Results: Ten studies (totaling 268 infants weighing 1000–2500g at birth) met inclusion criteria. All studies utilized whole-body TKS, involving stroking and movement with moderate to gentle pressure, administered 1 to 3 times daily by staff. Starting TKS in the first days of life seemed to improve meconium excretion, while later …

Trajectories Of Post Intensive Care Syndrome In Children During First Six Months Post-Discharge., Pei Fen Poh, Rehena Sultana, Joseph C. Manning, Matt Carey, Jos Latour

School of Nursing and Midwifery

Background and Aims: Health outcome trajectories in critically ill children remain poorly described. We aimed to examine the trajectories of post-intensive care syndrome within six-months post-pediatric intensive care unit (PICU) discharge.Methods: Data were collected upon PICU admission, discharge and at 1-, 3-, and 6-months post-discharge using the Pediatric Quality-of-Life scale (PedsQL™), Young Child PTSD Screen, and Functional Status Scale. Group-based trajectory modelling was used to identify distinct longitudinal health outcome trajectories.Results: 135 children completed follow- up and were categorised into three trajectory groups based on their health outcomes. Theme an (SD) age was 5.6(5.5) years, with PIM III score of …

‘The Transition Home With A Premature Baby’: How Prepared Are Parents For Discharge From Nicu: A Narrative Review, Beth Taylor, Kevin Hambridge

School of Nursing and Midwifery

Aims: To systematically review qualitative studies, investigating how prepared parents are for discharge home from NICU with their premature baby. Design: A qualitative narrative review and thematic synthesis of selected qualitative research evidence. Data sources: Searches were found between December 2022 and March 2023. Electronic databases (CINAHL, PsycINFO, PUBMED, Science Direct) were used. Additionally, Google Scholar for grey literature. Studies were searched within the ten-year time frame. Review methods: Seven primary studies met the inclusion criteria and were appraised for quality using the Critical Appraisal Skills Program tool. Qualitative data was collected, therefore creating a thematic synthesis. Results: Seven qualitative …

Bridging The Gap: Exploring The Potential Of Virtual Reality For Supporting Autistic Individuals In Interview And Recruitment Processes Through A Realist Review, Katie Edwards, Marius Varga, Michael Loizou

School of Nursing and Midwifery

The aim of this realist review was to systematically analyse the peer-reviewed academic literature, reports and blogs to determine: (1) the mechanisms and contexts by which recruitment and early employment experiences lead to poor outcomes for autistic adults, and (2) how a Virtual Reality (VR) intervention might lead to positive outcomes within the recruitment and early employment experiences for autistic adults. Throughout, we worked with a PPIE group of autistic people who were fully involved in the realist synthesis process. We identified challenges across the employment journey including limited vocational guidance and employment readiness support, exclusionary job descriptions, and traditional …

The Moral Regime Of Midwifery Continuity Of Carer Implementation In England, Aimee Louise Middlemiss, Susan Channon, Julia Sanders, Heather Strange, Rebecca Milton, Sara Kenyon, Tina Prendeville, Susan Barry, Aled Jones

School of Nursing and Midwifery

Since 2016, the National Health Service (NHS) in England has been aiming to implement midwifery continuity of carer (MCoC), a model of maternity care in which the same midwife or small group of midwives provides antenatal, intrapartum and postnatal care for women, other birthing people and their babies. However, the implementation has faced significant difficulties. As part of a wider investigation into barriers to and facilitators of MCoC implementation, we carried out qualitative interviews with senior stakeholders involved in the implementation of MCoC at regional or national level in England. In this paper, we present an analysis of sociocultural values …

A Multi-Center Comparative Analysis Of The G8-Score And Charlson Comorbidity Index As General Health Assessment Tools In Older Patients With Prostate Cancer, Brecht Chys, Philip R. Debruyne, Lore Decoster, Cindy Kenis, Hans Wildiers, Diederik Ponette, Steven Joniau

School of Nursing and Midwifery

Introduction Frail and older patients who develop prostate cancer (PCa), are at risk of overtreatment. Multiple general health assessment (GHA) tools have been validated in oncology. we aim to validate and compare the performance of the G8 screening tool, age and Charlson Comorbidity Index (CCI) as a predictor of overall survival (OS) in men older than 70 years with a newly diagnosed prostate cancer. Is it possible to identify a CCI cut-off indicative for frailty? Patients and methods Between 2009 and 2015, a national multicenter initiative on geriatric screening and GHA’s took place in Belgium. Baseline characteristics were collected on …

Mapping The Process Of Engagement With Digital Health Interventions: A Cross-Case Synthesis, Madison Milne-Ives, Sophie R. Homer, Jackie Andrade, Edward Meinert

School of Nursing and Midwifery

Objective: To map the associations between affective, cognitive, and behavioral components of engagement with digital health interventions to provide a framework to improve intervention design, evaluation, and impact. Patients and Methods: An exploratory multiple case study examined 3 studies evaluating a childhood obesity mobile application (NoObesity, data collection: from September 15, 2020 to June 23, 2021), a mental health conversational agent mobile application (Wysa, data collection: from December 13, 2022 to July 31, 2023), and a telephone-delivered conversational agent postsurgical assessment (Dora R1, data collection: from September 17, 2021 to January 31, 2022). Qualitative data from semi-structured interviews (NoObesity: n=15, …

Empowerment Of Parents In The Intensive Care: A Multicentre Validation Study In Japan, Yujiro Matsuishi, Joseph C. Manning, Haruhiko Hoshino, Yuki Enomoto, Ikkei Munekawa, Ryo Ikebe, Masanori Tani, Naoko Tanaka, Bryan J. Mathis, Nobutake Shimojo, Yoshiaki Inoue, Jos M. Latour

School of Nursing and Midwifery

Background: The importance of assessing family satisfaction in paediatric intensive care units (PICUs) is becoming increasingly recognised. The survey, EMpowerment of Parents in THe Intensive Care “EMPATHIC-30”, was designed to assess family satisfaction and has been translated and implemented in several countries but not yet in Japan. Objectives: The objective of this study was to translate, culturally adapt, and validate the EMPATHIC-30 questionnaire in Japanese and to identify potential factors for family-centred care satisfaction. Methods: We translated and adapted for patient-reported outcome measures via a 10-step process outlined by the Principles of Good Practice. Four paediatric PICUs in Japan participated …

A Retrospective Records Review Comparing The Care Of Patients Who Either Avoided Or Were Admitted To An Icu Following A Ward-Based Deterioration Event, J. Ede, H. Pickworth, B. Kent, P. Watkinson, R. Endacott

School of Nursing and Midwifery

Objectives: To identify escalation success factors documented in care records of patients who triggered an Early Warning Score ≥ 7 in the ward, avoided an Intensive Care Unit admission and survived and compare these with ward patients who triggered an Early Warning Score ≥ 7, went to intensive care and died during their admission. Methods: A multi-site, retrospective records review was conducted on 340 survivors and 50 non-survivors who were either admitted to, or who avoided intensive care. Results: Non-survivors of deterioration tended to be older, earlier into their hospital admission, and had a greater number of co-morbidities at the …

The Use Of Tele-Music Interventions In Supportive Cancer Care: A Systematic Review, Lore Mertens, Laura Tack, Tom Boterberg, Jörg Fachner, Leonardo Muller-Rodriguez, Marte Vandeweyer, Sofie Demasure, Marianne Hanssens, Tine Loyson, Laurence Goethals, Isabelle Kindts, Hannelore Denys, Patricia Schofield, Mohammad Najlah, Philip R. Debruyne

School of Nursing and Midwifery

Objectives: This systematic review seeks to provide an in-depth overview of current research on tele-music interventions in supportive cancer care and identifies key areas where further research is warranted. Methods: A comprehensive search was conducted across four electronic databases (Scopus, Embase, Web of Science, and PubMed) without any data restrictions and according to the PRISMA guidelines. The primary outcome measure was the effect of tele-music interventions on psychosocial functioning. Results: Of the 2.043 articles initially identified, nine studies met the inclusion criteria and were selected for qualitative analysis. Among the music interventions, considerable variation was observed regarding delivery format and …

Tolerance Of Ambiguity And Psychological Wellbeing In Newly Qualified Doctors: An Analysis Over Multiple Time Points, Tom Gale

Peninsula Medical School

Introduction: There is evidence of an association between tolerance of ambiguity and psychological wellbeing in doctors, but this relationship is not well understood. We explored this relationship, and the individual or workplace factors moderating it, in a population of newly qualified doctors. Methods: We examined the experiences of newly qualified doctors in the UK as they started a novel interim role (Time 1) and later moved into foundation year 1 roles (Times 2 and 3) during the COVID-19 pandemic. Doctors completed the Tolerance of Ambiguity of Medical Students and Doctors scale (TAMSAD Range: 0–100), the Perceived Stress Scale (PSS: 0–40), …

Systematic Review Of Paediatric Sudep And Epilepsy-Related Deaths To Inform A Safety Counselling Checklist For Clinical Practice, Rohit Shankar

Peninsula Medical School

BackgroundOne in 200 children - in the UK have epilepsy. Approximately, 1 in 1,000 children with epilepsy die yearly from Sudden unexpected death in epilepsy (SUDEP), a leading cause of death in epilepsy. Various risk factors contributing to epilepsy mortality particularly SUDEP, some modifiable, have been identified. Structured discussion of risks results in behavioural change that reduces individual risk factors.AimTo investigate and collate risk factors for SUDEP and epilepsy mortality in children to propose a structured communication tool (“Checklist”) for person centred communication.MethodsA Systematic review for children’s epilepsy mortality risk factors was conducted. The search strategy was developed by clinical …

Letter-To-The-Editor To The Study By Bartek J Et Al “Multidisciplinary Consensus-Based Statement On The Current Role Of Middle Meningeal Artery Embolization (Mmae) In Chronic Subdural Hematoma (Csdh)” – A Letter From The International Csdh Research Group Committee, Icoric, T.S.R. Jensen, J. Duerinck, D. Holl, C. Iorio-Morin, J. Soleman, E. Edlmann

Peninsula Medical School

No abstract provided.

Discussing Poverty Within Primary Care Consultations: Implications For Mental Health Support, F. Thomas, K. Wyatt, K. Berzins, I. Lee, J. Horrell, A. Mcloughlin

Peninsula Medical School

No abstract provided.

A Mapping Review Of Studies Exploring The Barriers And Facilitators To A Dementia Diagnosis Through An Intersectionality Lens, Ben Hicks, Katherine Wheatley, Emma Porter, Nicolas Farina, Sube Banerjee

Peninsula Medical School

BackgroundPromoting a ‘timely’ diagnosis is a global policy directive.AimsThis review adopts an intersectional approach, visually mapping the existing literature to highlight gaps in the evidence base on barriers and facilitators to dementia diagnosis.MethodA systematic approach was undertaken, following the PRISMA guidelines, updating previous reviews. The literature search was conducted on PubMed, PsycINFO, CINAHL Complete and Scopus. In line with mapping review methodology, we report the current state of the literature by describing the number of studies that outline barriers and facilitators to seeking help for a dementia diagnosis, split by social categorisation.ResultsOn the 7 June 2024, a total of 45 …

From Hospital Discharge To Long-Term Care: Unmet Rehabilitation Needs In Cauda Equina Syndrome Patients From A National Uk Cohort, Uces Collaborators, British Neurosurgical Trainee Research Collaborative, Holly Roy, Krithika Anil, Jack Read, Marcus J. Drake, Ingrid Hoeritzauer, Julie Woodfield

Peninsula Medical School

Objectives: Although long term disability may be a consequence of cauda equina syndrome (CES), the evidence base for the effect of rehabilitation or different rehabilitation strategies is lacking. Our aim was to understand long term neurological deficits (understood as rehabilitation needs) and current rehabilitation provision for patients with CES. Methods: We retrospectively analysed data from a large UK wide cohort of CES patients presenting between 1st June 2018 and 31st May 2019. Rehabilitation referrals and attendance were described, and symptoms at discharge and one year were identified as potential targets for rehabilitation. Results: Physiotherapy was the most common inpatient rehabilitation …

Comparative Analysis Of Lstm-Based And Traditional Hydrologic Models For River Discharge Prediction: A Case Study Of The Goose River, Adewale Ajao

Theses and Dissertations

Streamflow predictions are important in planning water resources and effective hydrological management. Physically based models such as the Hydrologic Engineering Center-Hydrologic Modeling System (HEC-HMS) have been used in the past for this purpose. Still, the use of machine learning models such as Long Short-Term Memory (LSTM) has been proven to complement the use of traditional models. This study compares the reliability performances of HEC-HMS and LSTM models to predict the streamflow of Goose River Watershed in North Dakota. The objective of the research is to perform a comprehensive comparative analysis between the performance of HEC-HMS and LSTM models to predict …

Mathematical Modeling Of Cyber-Physical Attacks In Iot Systems: An Epidemiological Approach, Tunde Alesinloye

Theses and Dissertations

The Internet of Things (IoT) has made electronic devices more interconnected, which has increased cybersecurity threats while also bringing previously unimaginable convenience. In this study, we explore the dynamics of malware transmission in IoT systems using a mathematical modeling methodology that draws inspiration from epidemiological approaches. To better characterize contemporary cyber-defense tactics like honeypots and proactive device hardening, we specifically suggest the SEIR-DX model, which expands the traditional SEIR framework by adding two extra compartments: Deceptive (D) and Secured (X).

The transitions between the six compartments Susceptible, Exposed, Infected, Recovered, Deceptive, and Secured are described by a system of nonlinear …

Machine Learning-Guided Discovery Of Metal-Ligand Catalysts For Affordable Green Hydrogen Produced Via Proton Exchange Membrane Electrolyzers, Achouak Benarbia

Theses and Dissertations

The rising demand for clean and sustainable energy sources has underscored the critical role of hydrogen in the global energy transition. However, the widespread adoption of green hydrogen remains constrained by the high cost and scarcity of platinum-based electrocatalysts used in Proton Exchange Membrane (PEM) electrolyzers. This dependence inflates production costs and poses long-term risks related to supply security and scalability. While numerous studies have explored alternative materials, the discovery of efficient and stable non-platinum catalysts remains a major bottleneck due to the vastness of chemical space and the resource-intensive nature of experimental screening. To address this challenge, this study …

Next-Gen Device For Uniform Cellular Migration Assay Execution, Nicholas M. Bittner

Theses and Dissertations

Cellular migration assays, particularly scratch assays, are pivotal in biomedical research for cell motility, wound healing, and metastasis. However, conventional scratch assays suffer from variability due to operator dependence, non-uniform scratch geometry, and a modified microenvironment that impacts reproducibility. This thesis presents the development and validation of a low-cost, 3D-printed device designed to standardize cellular migration assays. The device utilizes a spring mechanism and a biocompatible elastomer to create a uniform cellular exclusion zone without harming the surrounding cells. Through iterative prototyping and testing with MCF10A cell lines, the device demonstrated a significantly lower average standard deviation of length compared …

Characterization Of Methylated Histone Modifications During Simian Virus 40 Early Transcription, Jacob Otto Haugen

Theses and Dissertations

Modifications of histone proteins play an important role in transcription. These modifications regulate how chromatin is compacted by the histone proteins and either made available for transcription or prevents transcription machinery from proceeding. The modifications can be added or removed by histone acetyltransferases and histone methyltransferases for the former, and histone deacetylates and demethylases for the latter. To explore the dynamicity of these modifications we used the simple but effective Simian Virus 40 (SV40) model. SV40 continues to be an important tool in understanding eukaryotic transcription. It experiences similar processes as cellular chromatin, utilizing host proteins to propagate its own …

Thermally Induced Evolution Of The Cement Microannulus In Co2 Injection Wells, Jawad Ali Khan

Theses and Dissertations

Ensuring wellbore integrity during CO₂ injection is a critical challenge in Carbon Capture and Storage (CCS), as failures at the casing-cement and cement-formation interfaces can create potential leakage pathways. This dissertation presents a multi-scale, physics-based investigation into well integrity risks, integrating finite element analysis (FEA), thermal-mechanical-poroelastic modeling, and transient stress analysis to evaluate cement sheath stability, fracture-driven stress localization, and microannulus formation under various CCS conditions.

A key novelty of this research is the development of a fully coupled thermal-mechanical-poroelastic FEA framework using COMSOL Multiphysics, a renowned industry-standard software for multiphysics simulations. This model enables a dynamic, time-dependent assessment …

Evaluating Human Factors In Isolation And Confinement During Analog Spaceflight: A Decadal Survey Assessing Ilmah Crew Psychology, Travis Michael Nelson

Theses and Dissertations

This study examined 13 crews participating in analog Martian surface simulations to investigate psychological experiences within the first collegiate planetary surface habitat. The University of North Dakota (UND) Integrated Lunar-Martian Analog Habitat (ILMAH) was utilized with high-performing participant crews (n=42) who were recognized and recruited for their skills. Common environmental similarities that each crew faced included isolation, confinement, time-latent communications, demanding work hours, monotonous tasks, physically strenuous Extravehicular Activities (EVA), personal psychological adaptations, and interpersonal psychosocial challenges. The primary objective of this study was to evaluate self-appraised crew performance measures across continuous phases of isolation and confinement lasting up to …

From Design To Deployment: A Holistic Perspective On Design Frameworks, Stability Analysis, And Control Innovations Of Dc Microgrid Architectures, Sandipan Patra, Malabika Basu, Shafi Khadem

Research Outputs: 2025-Present

Now-a-days, DC microgrids (DCMGs) are gaining significant traction due to their higher reliability, simpler control strategies and the absence of challenges like synchronisation, harmonics, reactive power regulation, and frequency control. However, integrating various and distributed energy resources in the same DC bus complicates the regulation of the DC bus voltage and power sharing. Various DCMG design architectures have been proposed to enhance power availability, efficiency, and reliability. These architectures usually can be classified into four main types, i.e., single bus, multi-bus, bipolar bus, and reconfigurable bus topologies. Diverse control strategies, including centralised, decentralised, distributed, and hierarchical control with different architectures, …

Teacher Delivered Block Construction Training Improves Children's Mathematics Performance, Emily K. Farran, Katie A. Gilligan-Lee, Denis Mareschal, Marija Živković, Santa Bartušēvica, Derek Bell, Tim Jay, Camilla Gilmore

Research Outputs: 2025-Present

There is robust evidence for a causal association between spatial thinking and mathematics achievement. However, most research has been lab-based, with spatial training delivered by researchers. We present a teacher delivered, whole-class 6-week spatial training study that involved professional development for practitioners coupled with teacher-led LEGO® block construction training for 6- to 7-year-olds. Using a quasi-experimental design, N = 409 children completed the training and N = 103 children formed a business-as-usual control group. For spatial ability and mathematics, but not spatial language, children in the training condition showed improved performance relative to controls. This finding extends evidence of the …

Beyond Genes: Non-Canonical Mechanisms Driving Antimicrobial Resistance In Bacteria, Leonard Koolman, Chijioke Emenike, Debasis Mitra, Sourav Chattaraj

Research Outputs: 2025-Present

Antimicrobial resistance (AMR) is traditionally discussed in the context of horizontally acquired resistance genes and point mutations at target loci. However, this gene-centred model fails to account for a large number of clinically important modalities of resistance. There is now substantial evidence implicating bacteria in the ability to escape the effects of antibiotics in a variety of non-canonical ways, which are not considered in traditional diagnostic and surveillance pipelines. Among these factors, we can list those arising from global regulatory networks, phase variability, epigenetic tuning, small RNAs, genome structural variability, and phenotypic states like tolerance and persistence. This review will …

Enhanced Force Sensing Utilizing A Glass-Supported Wgm Microbubble Resonator, Yiming Shen, Zhe Wang, V. R. Anand, Zhuochen Wang, Rayhan Habib Jibon, Anuradha Rout, Bo Cai, Qiang Wu, Yuliya Semenova

Research Outputs: 2025-Present

Mechanical force sensors are critical for a wide range of advanced applications. This paper presents a high-performance whispering gallery mode (WGM) force sensor based on a glass-supported microbubble resonator (MBR). By incorporating the proposed glass support design, the proposed sensor achieves the highest force sensitivity reported for MBR-based structures, of 125.71 pm/mN and a detection limit of 52.26 μN. The sensor has a response time of 3.5 ms, enabling rapid detection of dynamic force changes. Further tests show that the sensor is capable of detecting subtle forces, such as those created by water droplets and a gentle breeze, paving the …

A Monitoring Automation Recipe Cookbook: Simple Open-Source Solutions For Home-Based Support Of People Living With Dementia And Their Caregivers, Harish Kambampati, Damon Berry, Julie Doyle, Orla Moran, Jonathan Turner, Micheal Wilson, Suzanne Smith, Dympna O’Sullivan

Research Outputs: 2025-Present

Activities of Daily Living (ADLs) are vital to maintaining quality of life among People Living with Dementia (PLwD), whose cognitive impairment often impacts independence in daily activities. This paper presents smart home automation “recipes” that can assist ADLs, particularly bathing—safely one of the most complex due to safety risks like falls and burns. The automation recipes incorporate open-interface sensors, motion detection, and real-time alerts, with features targeted at dementia progression stages.Interventions at early stages include voice reminders and water temperature automatic adjustments; middle-stage features include safety reminders, activity-based inactivity detection, and water shut-off; caregiver-aided monitoring forms the interventions at late …