Open Access. Powered by Scholars. Published by Universities.®

Digital Commons Network™

Open Access. Powered by Scholars. Published by Universities.®

2025

Discipline
Institution
Keyword
Publication
Publication Type
File Type

Articles 88051 - 88080 of 88266

Full-Text Articles in Entire DC Network

Roosting Habits Of Male Silver-Haired Bats In The Willard Creek Drainage Of Northeastern California, Alexander Christopher Lewis Jan 2025

Roosting Habits Of Male Silver-Haired Bats In The Willard Creek Drainage Of Northeastern California, Alexander Christopher Lewis

Cal Poly Humboldt theses and projects

Silver-haired bats (Lasionycteris noctivagans) are one of the most widely distributed forest bats in North America. Although wildfires have been increasing across their range, how they respond to wildfire is understudied. Previous studies on silver-haired bats and fire focused on roosting behavior in low-severity controlled burns or used acoustics to understand activity levels post-wildfire. Quantifying how silver-haired bats use the physical structures created by high-severity wildfires and the landscape features in which they occur is critical in the face of rapidly shifting fire regimes. During the summer of 2023 and 2024 I radio-tracked male silver-haired bats to 37 roosts …


Just Keep Swimming: Outmigration Survival Of Upper Klamath Basin Juvenile Chinook Salmon, James M. Whelan Jan 2025

Just Keep Swimming: Outmigration Survival Of Upper Klamath Basin Juvenile Chinook Salmon, James M. Whelan

Cal Poly Humboldt theses and projects

The removal of four impassable hydroelectric dams on the Klamath River provides salmonids with the opportunity to recolonize their historic range in the upper Klamath River watershed. However, successful reestablishment of salmon populations requires juvenile salmon born in Oregon's upper tributaries to safely migrate downstream through the river's upper reaches. This stretch of the Klamath River, immediately downstream of Upper Klamath Lake, presents multiple migration challenges, including two flow-control dams not scheduled for removal (Link River Dam and Keno Dam), significant water diversions, and water quality issues. To evaluate these challenges, I conducted experimental releases of radio-tagged juvenile Chinook salmon …


True Crime Podcasts As A Scene Of Feminist Reckoning: A Comparative Analysis Of My Favorite Murder And Sistas Who Kill, Rachel C.C. Matteri Jan 2025

True Crime Podcasts As A Scene Of Feminist Reckoning: A Comparative Analysis Of My Favorite Murder And Sistas Who Kill, Rachel C.C. Matteri

Cal Poly Humboldt theses and projects

This research examines the cultural impact and ethical implications of true crime podcasts (TCPs). In recent years, TCPs have become a powerful cultural force, with White women often emerging as the primary storytellers and most visible participants in the genre. Their dominance in this space is not neutral and it carries representational weight. It explores the potential for feminist activity made possible by the auditory, self-publishing genre of podcasting. This work focuses on the buddy-comedy subgenre of TCPs. The concerns of this text are that TCPs are dominated by White feminist values and are not an intersectional feminist project. Textual …


Effects Of Teacher Reinforcements On Student Outcomes In Adapted Physical Education: A Meta-Analysis, Yaxeny Moreno Jan 2025

Effects Of Teacher Reinforcements On Student Outcomes In Adapted Physical Education: A Meta-Analysis, Yaxeny Moreno

Cal Poly Humboldt theses and projects

The primary goal is to review the influence of reinforcement strategies in Physical Education (PE) and Adapted Physical Education (APE) settings, focusing on students with disabilities with the ages of 3-22. Reinforcement strategies, such as positive reinforcement/feedback, token economies, verbal praise, tangible rewards, and additional strategies are essential for fostering engagement and skill development. Literature has provided evidence and results to highlight the importance of applying evidence-based reinforcement strategies to which support the behavioral, social, and physical development of students in both Physical Education and Adapted P.E. settings. The purpose of this study was to review and analyze existing literature …


Exploring The Placebo Effect On The Cortisol Stress Response, Povheng Yam Jan 2025

Exploring The Placebo Effect On The Cortisol Stress Response, Povheng Yam

Cal Poly Humboldt theses and projects

The placebo effect is well-studied on pain perception and is often observed to have a pain-reducing effect in patients. A few studies suggest that the placebo effect can influence physiological changes in people. To date, not many studies have examined the placebo effect on stress; thus, the current study explored the placebo effect on participants’ cortisol stress response and self-reported stress while undergoing a modified acute stress task, the Sing-a-Song Stress Test (SSST). The current study includes 44 participants (22 in the control group and 22 in the treatment group). A deceptive stress-reducing tincture (filled with water) was used as …


Lineation To Liberation: The Transformative Power Of Poetic Rhetoric, Amber Rae Alvarez Jan 2025

Lineation To Liberation: The Transformative Power Of Poetic Rhetoric, Amber Rae Alvarez

Cal Poly Humboldt theses and projects

This project explores the transformative power of poetic rhetoric and examines how poetry as a form of expressive art serves as a means of reclamation in the aftermath of encounters with the American criminal justice system. I contend that poetry provides a space where folks can reimagine (and reclaim) their identities, asserting their agency in empowering and authentic ways. Taking a Cultural Studies and Critical Prison Studies informed approach, this project engages the concept of lineation to liberation to conduct a close reading analysis of artist (Reginald) Dwayne Betts’ poetry. Betts’ work not only provides a powerful example of how …


Facilitating On-Task Behavior In Physical Education For Learners With Asd Through Special Interest Modified Materials: Antecedent-Based Intervention, Gary Smith Jan 2025

Facilitating On-Task Behavior In Physical Education For Learners With Asd Through Special Interest Modified Materials: Antecedent-Based Intervention, Gary Smith

Cal Poly Humboldt theses and projects

Children with Autism Spectrum Disorder (ASD) are affected in the areas of social skills, communication, and restrictive and repetitive behaviors that can lead to barriers in accessing physical education (PE). School-based PE helps children learn how to develop the knowledge, skills, and confidence to live physically active lifestyles. The purpose of this current study is to implement an antecedent based intervention using special interest materials to increase on task and engagement in learners with ASD in PE activities. The intervention showed modest to minimal improvements in on-task behavior and performance for two of the three participants, with high variability and …


An Analysis Of Uv Disinfection Of Municipal Wastewater Following Natural Treatment Systems, Jonathan Andrew Kirchubel Jan 2025

An Analysis Of Uv Disinfection Of Municipal Wastewater Following Natural Treatment Systems, Jonathan Andrew Kirchubel

Cal Poly Humboldt theses and projects

On January 30, 2024, the City of Arcata replaced chlorine with ultraviolet (UV) irradiation as its disinfection method for treating its wastewater prior to discharging to Humboldt Bay. The Arcata wastewater treatment facility (AWTF) utilizes natural treatment systems for treating its secondary effluent, which can provide issues for UV disinfection through variance in turbidity, total suspended solids (TSS), pH, humic acids, and color. This project aimed to identify whether the water quality characteristics of natural treatment systems in the AWTF would impact UV disinfection of municipal wastewater.

Thirty-one sampling periods occurred between June 8, 2024, and March 1, 2025, recording …


Common Raven Habitat Selection Along The Northern California Coast, Alon Averbuj Jan 2025

Common Raven Habitat Selection Along The Northern California Coast, Alon Averbuj

Cal Poly Humboldt theses and projects

Nest predation by common ravens (Corvus corax) is considered one of the most significant barriers to the recovery of the population of the federally threatened western snowy plovers (Anarhyncus nivosus nivosus) in Northern California. To increase productivity of snowy plovers, conservation managers in Northern California employ three main techniques; placing symbolic fencing to deter pedestrian entrance to snowy plover nesting areas, invasive vegetation cutback, and deposition of oyster shells to increase snowy plover nest crypsis. However, little is known on how these techniques affect habitat selection of ravens in the area. I modeled habitat selection of …


Breaking Barriers: The First-Generation Experience In Pursuit Of The American Dream, Milagros Ortega Jan 2025

Breaking Barriers: The First-Generation Experience In Pursuit Of The American Dream, Milagros Ortega

Cal Poly Humboldt theses and projects

This project examines the common misconceptions surrounding First-Generation Latino college students and challenges the dominant narrative that portrays them as unprepared, unsupported, and unmotivated. Through narrative and content analysis of the short films, Ni de Aquí, Ni de Allá and Turns in the Road, this project explores the overlapping challenges that complicate their educational journeys. These challenges, financial instability, lack of guidance, and sociocultural dissonance, represent three core barriers commonly faced by first-generation Latino college students. Guided by theoretical frameworks such as the Immigrant Optimism Hypothesis, W.E.B Du Bois’ theory of double consciousness, Gloria Anzaldúa’s concept of Nepantla, and Yosso’s …


Investigating Fish Communities As Part Of The Food Web In Artificial Tidal Wetland Ponds Of Humboldt Bay, Ca, Lily M. Olmo Jan 2025

Investigating Fish Communities As Part Of The Food Web In Artificial Tidal Wetland Ponds Of Humboldt Bay, Ca, Lily M. Olmo

Cal Poly Humboldt theses and projects

In the face of global wetland loss, artificially created wetlands have the potential to restore ecosystem services for humans while also providing habitat for fish and wildlife. This study explored fish communities in three understudied artificial wetland ponds that are connected to Humboldt Bay in northern California and known to be important wildlife foraging areas. The objectives of this research were to 1) Characterize the environmental conditions of each pond, 2) Calculate the relative catch, richness, diversity, and biomass of fish in each pond, 3) Describe the movement of fish into and out of the ponds with the tides, and …


Bat Species Diversity In The Klamath Basin Prior To Dam Removals, Ryan Page Matilton Jan 2025

Bat Species Diversity In The Klamath Basin Prior To Dam Removals, Ryan Page Matilton

Cal Poly Humboldt theses and projects

River ecosystems make up a small percentage of the earth’s surface, but they support high levels of biodiversity and attract high levels of human use. Dams, for example, disrupt a river’s natural course and flow, alter water temperatures in the stream, redirect river channels, transform floodplains, and fragment river continuity, which affects ecological balance and food webs. The Klamath River in northern California, which has been dammed for the last century, experienced dramatic disruptions including a large fish die-off in 2002. With the negative impacts of the Klamath dams apparent, multiple entities negotiated to remove the dams and restore the …


Fleeing Structural Stigma: Psychological Outcomes For Transgender And Gender-Diverse Internally Displaced Persons, Max E. Cartagena Jan 2025

Fleeing Structural Stigma: Psychological Outcomes For Transgender And Gender-Diverse Internally Displaced Persons, Max E. Cartagena

Cal Poly Humboldt theses and projects

In 2025, at least 1,000 bills targeting transgender and gender-diverse (TGD) individuals were introduced across the United States, contributing to an environment of escalating structural stigma. As a result, many TGD individuals have relocated from states with high levels of stigma to those with lower levels in search of safety, access to care, and social affirmation. This study examines these individuals as internally displaced persons (IDPs) and is informed by refugee psychological literature, as both experiences arise from coercive structural forces that compel individuals to relocate. This perspective highlights the involuntary nature of their migration, driven by the need for …


Modeling Forest Stewardship In Goukdi’N: An Assessment Of Carbon, Wildlife Habitat, And Fire Resilience In A University Forest, Benjamin Stock Jan 2025

Modeling Forest Stewardship In Goukdi’N: An Assessment Of Carbon, Wildlife Habitat, And Fire Resilience In A University Forest, Benjamin Stock

Cal Poly Humboldt theses and projects

This thesis presents a forest management plan for Goukdi’n (also known as the Jacoby Creek Forest University Tract), a coast redwood–tanoak–Douglas-fir forest within the ancestral homelands of the Wiyot Tribe. This project addresses the need for a forest stewardship approach that supports ecological resilience, cultural values, and long-term forest health in a landscape shaped by industrial logging, fire exclusion, and decades of under-management. To evaluate potential management pathways, forest growth modeling was conducted using the USFS Forest Vegetation Simulator (FVS) to compare three management prescriptions focused on carbon storage, fire resilience, and structural heterogeneity and a no-action alternative. Model outputs …


Effects Of Experimental Structural Retention Position And Aggregation On Avian Communities In Managed Forests Of The Pacific Northwest, U.S., Aidan M. Healey Jan 2025

Effects Of Experimental Structural Retention Position And Aggregation On Avian Communities In Managed Forests Of The Pacific Northwest, U.S., Aidan M. Healey

Cal Poly Humboldt theses and projects

Managed forest lands in Oregon and Washington produce wood products and host diverse bird communities, though standing dead snags are often limited. State forest practices rules governing forest harvest dictate retention of a minimum number of trees when forests are clearcut harvested. However, little research has explored how the slope position and aggregation of retention, and the supplemental inclusion of mechanically created snags, affects use of these forest units by wildlife, especially highly mobile taxa such as birds. I used an avian point count sampling approach, within a replicate-block experiment dictating unit-level slope position, aggregation, and snag retention treatments, to …


Estimating Mariana Monitor (Varanus Tsukamotoi) Density With Multiple Methods On Islan Dåno’, Guam, And Its Relevance To Guam Rail (Hypotaenidia Owstoni) Conservation, Jack T. Christie Jan 2025

Estimating Mariana Monitor (Varanus Tsukamotoi) Density With Multiple Methods On Islan Dåno’, Guam, And Its Relevance To Guam Rail (Hypotaenidia Owstoni) Conservation, Jack T. Christie

Cal Poly Humboldt theses and projects

The Mariana monitor (Varanus tsukamotoi), or hilitiai, is a medium-sized varanid lizard found throughout the Mariana islands. On Islan Dåno’, a small islet off the southwest coast of Guam, hilitai coexist with one of the rarest birds in the world, the Guam rail (Hypotaenidia oswtoni), or ko’ko’, which were introduced to the island in 2010. Since 2009, hilitai have been lethally removed from the island to reduce possible predation on ko’ko’. After 15 years of removal efforts, I sought to 1) estimate the abundance and density of hiltai, 2) assess the effect of removal effort and …


Examining The Effects Of Songbird Nest Boxes And Habitat On Avian And Arthropod Communities In A Vineyard Ecosystem, Eleanor Macdonald Jan 2025

Examining The Effects Of Songbird Nest Boxes And Habitat On Avian And Arthropod Communities In A Vineyard Ecosystem, Eleanor Macdonald

Cal Poly Humboldt theses and projects

Agricultural expansion threatens biodiversity, but integrating insectivorous birds into vineyard ecosystems may support both conservation and ecosystem services. We tested how nest boxes and habitat composition influence avian and arthropod communities in Napa Valley vineyards using a before-after, control-impact experiment across 20 sites. During the 2023-2024 breeding seasons we conducted avian point counts, sampled key pest and beneficial arthropods, and collected fecal samples from adult and nestling tree swallows (Tachycineta bicolor) and western bluebirds (Sialia mexicana) to detect vineyard pest DNA. Nest boxes significantly increased swallow and bluebird abundance within one year; swallow responses were strongest …


The Effects Of Chronic Absenteeism On Average Daily Attendance Funding In Humboldt County Elementary Schools, Corabelle A. Esmailian Jan 2025

The Effects Of Chronic Absenteeism On Average Daily Attendance Funding In Humboldt County Elementary Schools, Corabelle A. Esmailian

Cal Poly Humboldt theses and projects

Chronic absenteeism is linked to poor academic performance and lower social-emotional skills, both of which can have long-term effects on students and their communities. The California Department of Education uses average daily attendance (ADA) to determine most of the funding that public schools receive. When a student is absent, their school loses a portion of potential funding for that day. This study explores chronic absenteeism’s impact on the funding of Humboldt County’s elementary schools with a sequential exploratory research strategy and critical systems lens. Interviews with elementary administrators were conducted using a phenomenological approach to understand how this affects their …


Wait... Homework Can Be Fun?! A Pilot Homework System Study, Caroline Brock Jan 2025

Wait... Homework Can Be Fun?! A Pilot Homework System Study, Caroline Brock

Cal Poly Humboldt theses and projects

Homework has been a long-debated topic in schools. Regardless of where people stand on the issue, the evidence shows that quality homework can be an effective tool to help students be successful in school. Beyond academics, homework can also be used as a tool to help students develop important foundational study skills that are critical for future success. But how can school districts get all stakeholders behind a homework system if they do not see the value of homework, or if the homework is a point of individual or familial stress. Through an action research project using mixed methods, parents …


Examining The Impact Of A Health Course On Lifelong Learner Attitudes Toward Psychedelic And Entheogenic Substances, Dustin B. Larrazolo Jan 2025

Examining The Impact Of A Health Course On Lifelong Learner Attitudes Toward Psychedelic And Entheogenic Substances, Dustin B. Larrazolo

Cal Poly Humboldt theses and projects

This study examined the impact of a three-week Osher Lifelong Learning Institute (OLLI) health course, “Far Out” Medicine: The Science and History of Psychedelics, on midlife and older adult learners’ knowledge, attitudes, and perspectives regarding psychedelic and entheogenic substances. Eleven midlife and older adults (ages 40 - 80; M = 59.0, SD = 15.35) completed matched pre- and post-course surveys assessing demographic characteristics, factual knowledge, attitudes, personal willingness, and social or policy views. The sample was highly educated (1 associate, 5 bachelor’s, 3 master’s, and 2 doctoral degrees) and demonstrated strong internal consistency and response convergence across repeated measures. …


Sex Work And Covid-19: An Intersectional Discussion Of U.S.-Based Sex Worker Experiences During The Pandemic, Sabrina M. Grandia Jan 2025

Sex Work And Covid-19: An Intersectional Discussion Of U.S.-Based Sex Worker Experiences During The Pandemic, Sabrina M. Grandia

Cal Poly Humboldt theses and projects

The COVID-19 pandemic impacted all forms of industry, including that of sex work. Between October 2020 until November 2022, I did field research and interviews with nine U.S.-based sex workers throughout those months of the pandemic. Using a grounded theory approach, I asked open-ended questions about their entrance into the industry, business practices, and personal experiences before and during the pandemic. Their stories allow us to gain insight into the impact the pandemic had on them as individuals and their broader communities. My analysis highlights a prominent influence of anti-trafficking policy, politicization of the virus, and the impact of Black …


The Impact Of Guided Goal Setting On Mood And Exercise Performance In College-Age Active Individuals, Payton R. Heaney Jan 2025

The Impact Of Guided Goal Setting On Mood And Exercise Performance In College-Age Active Individuals, Payton R. Heaney

Cal Poly Humboldt theses and projects

Mental health challenges are common in college students and student athletes, yet finding accessible and effective methods to improve mood and mood disorders remains under-researched. Mood is closely related to perceived performance, making mood improvements even more important for active college individuals. This study examined whether guided goal setting and health coaching could significantly improve mood as well as perceived performance. Sleep and nutrition were targeted as key factors due to their well-researched connection to mood. Participants of this study were 25 healthy active college individuals aged 18-35. The sports and activities represented in this study were a mix of …


Elementary Teachers' Knowledge Towards Teaching Physical Education, Hannah Lee Mandy Jan 2025

Elementary Teachers' Knowledge Towards Teaching Physical Education, Hannah Lee Mandy

Cal Poly Humboldt theses and projects

This study examined elementary teachers’ preparation in physical education (PE) and its impact on teaching effectiveness for students, including students with disabilities. Twenty-seven teachers completed a survey and three participated in a follow-up focus group where participants were asked to expand on previous questions. Findings revealed limited PE coursework, minimal hands-on experience and low familiarity with the California Physical Education Standards in teacher preparation programs. Additionally, only 74 percent of participants completed a PE course during their teacher preparation program and focus group participants emphasized their preparation programs focused on lesson planning rather than hands on teaching, and the programs …


Environmental And Spatial Drivers Of Quillback Rockfish (Sebastes Maliger) Growth In The Northeast Pacific Ocean From California To Alaska, Claire E. Stuart Jan 2025

Environmental And Spatial Drivers Of Quillback Rockfish (Sebastes Maliger) Growth In The Northeast Pacific Ocean From California To Alaska, Claire E. Stuart

Cal Poly Humboldt theses and projects

Quillback rockfish (Sebastes maliger) are a nearshore fishery species found across the Northeast Pacific Ocean, but recent stock assessments have identified a research gap for biological growth parameters, particularly for the southern end of their range. Age-length data compiled from California to Alaska (n=34,396) was used to generate extended von Bertalanffy models with spatial, biological, and environmental covariates, specifically region, sex, depth, and an upwelling index. The objectives of this study were to explore how 1) spatial and 2) environmental covariates affect model parameters L∞, k, and t0. Four total models were developed: …


Large Language Models And Identity: A Reflexive Approach, Nicholas Austin Nielsen Jan 2025

Large Language Models And Identity: A Reflexive Approach, Nicholas Austin Nielsen

Cal Poly Humboldt theses and projects

This project explicates theories of identity, technology, and capitalism and uses an auto ethnographic approach in order to apply that explication at a personal level. The project responds to AI rhetoric in business and pedagogy and the instability surrounding perspectives on job security, the role of technology in Higher Education, and existential representations of the human. By deconstructing identity, ideology, cultural contexts, and technologic rhetorics, the goal is to further the scholarship surrounding Large Language Model applications in pedagogy and offer a personal, therapeutic approach to feelings of economic and existential discontent and fear experienced by students and educators regarding …


Curriculum Addressing Recidivism: A Case Study Of Project Rebound’S Youth Empowerment Program, Julie Stewart Jan 2025

Curriculum Addressing Recidivism: A Case Study Of Project Rebound’S Youth Empowerment Program, Julie Stewart

Cal Poly Humboldt theses and projects

Providing effective rehabilitation for justice-involved youth is an increasing priority within the American social justice system, yet remains a significant challenge. The Youth Empowerment Program (YEP) at Cal Poly Humboldt uses curriculum to support learning objectives related to emotional intelligence, critical thinking, and emotional maturation, with the broader goal of reducing recidivism among youth in Northern California. Although curriculum design is widely understood in education as essential for effective learning, limited research examines how youth rehabilitation programs in carceral settings use curriculum to address the developmental and learning needs of participants. Using a case study methodology, this research examines how …


Looking At God, Looking At America: Examining The Relationship Between Beliefs About God And Support For Social Movements And Government Policies, Tess Starman Phd Jan 2025

Looking At God, Looking At America: Examining The Relationship Between Beliefs About God And Support For Social Movements And Government Policies, Tess Starman Phd

Sociology: Faculty Publications

Scholars have long studied the relationship between religion and politics. This study aims to add to the conversation on this relationship by assessing a unique religiosity measure, that of beliefs about the character of God. Utilizing the 2021 Values and Beliefs of the American Public (n=1,336), this study assesses how beliefs about God independently and comparatively impact support for government policies and social movements. Results show that the belief that God is active in the world has the greatest association with policy attitudes. Further, racial identity is a significant moderator for the relationship between belief that God is active and …


Location And Extent Of Disease Predicts Outcome Of Neurofibromatosis Type 1-Related Pediatric Low-Grade Gliomas, Sneha M Chaturvedi, Arohi Saxena, Ahmad Hassan, Ali Mian, Chelsea Kotch, Nicole M Brossier Jan 2025

Location And Extent Of Disease Predicts Outcome Of Neurofibromatosis Type 1-Related Pediatric Low-Grade Gliomas, Sneha M Chaturvedi, Arohi Saxena, Ahmad Hassan, Ali Mian, Chelsea Kotch, Nicole M Brossier

2020-Current year OA Pubs

No abstract provided.


Revisiting Abdominal Wall "Morbidity" Of The Extensile Anterolateral Approach To The Thoracolumbar Spine, Alekos A Theologis, Andrew P Collins, Kanwar Parhar, Munish C Gupta Jan 2025

Revisiting Abdominal Wall "Morbidity" Of The Extensile Anterolateral Approach To The Thoracolumbar Spine, Alekos A Theologis, Andrew P Collins, Kanwar Parhar, Munish C Gupta

2020-Current year OA Pubs

PURPOSE: To assess patients' perceptions of their abdominal wall following extensile anterolateral approaches to the thoracolumbar spine for adult spinal deformity (ASD) using validated questionnaires.

METHODS: Adults who underwent anterior-posterior thoracolumbar spinal operations to the pelvis for ASD in which the anterior fusion was performed through an extensile anterolateral approach were reviewed. Three questionnaires were administered at least 1 year following surgery and included The Abdominal Core Health Quality Collaborative Survey (AHS-QC), The Patient Scar Assessment Scale (PSAS), and The Anterior Abdominal Incision Questionnaire (AAIQ).

RESULTS: Fifty-one patients (80.4% female, median age 65 years) were included. Average follow-up was 2.8 …


Novel Loci For Triglyceride/Hdl-C Ratio Longitudinal Change Among Subjects Without T2d, Lihua Wang, Siyu Wang, Jason A Anema, Vaha A Moghaddam, Yanli Lu, Shiow Lin, E Warwick Daw, Allison L Kuipers, Iva Miljkovic, Michael Brent, Gary J Patti, Bharat Thygarajan, Joseph M Zmuda, Michael A Province, Ping An Jan 2025

Novel Loci For Triglyceride/Hdl-C Ratio Longitudinal Change Among Subjects Without T2d, Lihua Wang, Siyu Wang, Jason A Anema, Vaha A Moghaddam, Yanli Lu, Shiow Lin, E Warwick Daw, Allison L Kuipers, Iva Miljkovic, Michael Brent, Gary J Patti, Bharat Thygarajan, Joseph M Zmuda, Michael A Province, Ping An

2020-Current year OA Pubs

Triglyceride (TG)/HDL-C ratio (THR) is a surrogate predictor of hyperinsulinemia. To identify novel genetic loci for THR change over time (ΔTHR), we conducted genome-wide association study (GWAS) and genome-wide linkage scan (GWLS) among nondiabetic Europeans from the Long Life Family Study (n = 1,384). Subjects with diabetes or on dyslipidemia medications were excluded. ΔTHR was derived using growth curve modeling and adjusted for age, sex, field centers, and principal components. GWAS used a linear mixed model accounting for familial relatedness. GWLS employed haplotype-based identity-by-descent estimation with 0.5 cM average spacing. Heritability of ΔTHR was moderate (46%). Our GWAS identified a …