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2025

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Sulfur Cycling In The Gabbroic Section Of The Oman Ophiolite, Ana P. Jesus, Harald Strauss, Mário A. Gonçalves, Michelle Harris, Diogo Silva, Martin J. Whitehouse, Damon A.H. Teagle Jan 2025

Sulfur Cycling In The Gabbroic Section Of The Oman Ophiolite, Ana P. Jesus, Harald Strauss, Mário A. Gonçalves, Michelle Harris, Diogo Silva, Martin J. Whitehouse, Damon A.H. Teagle

School of Geography, Earth and Environmental Sciences

We present sulfur mineralogy and isotope geochemistry from the gabbro transect of the Oman Drilling Project to unravel the sulfur cycle during hydrothermal alteration of the plutonic oceanic crust. The sheeted dike–gabbro transition (Hole GT3A) shows low sulfide‑sulfur concentrations (GT3Amedian = 178 ppm, σ = 4873 ppm) but with great sulfur isotope variability (δ34S = −12.8 to 14.4 ‰ V-CDT, weighted average + 5.8 ‰) and unusually heavy compositions relative to in-situ or ophiolitic crust. These features are consistent with abiogenic thermochemical sulfate reduction during intense hydrothermal alteration under greenschist facies conditions which formed a low-variance and …


Global And Regional Estimation And Evaluation Of Suitable Roof Area For Solar And Green Roof Applications, Diana Ürge-Vorsatz, Souran Chatterjee, Luisa F. Cabeza, Gergely Molnár Jan 2025

Global And Regional Estimation And Evaluation Of Suitable Roof Area For Solar And Green Roof Applications, Diana Ürge-Vorsatz, Souran Chatterjee, Luisa F. Cabeza, Gergely Molnár

School of Geography, Earth and Environmental Sciences

Buildings contribute to 40% of energy consumption and 30% of CO2 emissions in 2019 globally, therefore it is necessary to exploit different solutions to decrease the corresponding energy demand, including green and cool roofs as well as on-site energy generation. To evaluate the potential of such technologies, one major input data for models and calculations is the available roof area, yet the literature shows a huge knowledge gap in this regard. Therefore, this paper contributes to filling this gap by estimating the roof availability over the period 2022–2060, using the detailed regional projections of the BISE (Building Integrated Solar …


Changes In The Spatiotemporal Patterns Of Covid-19 In Japan From 2020 Through 2023, Atsuna Tokumoto, Kazuaki Jindai, Tomoki Nakaya, Mayuko Saito, Clive E Sabel, Hitoshi Oshitani Jan 2025

Changes In The Spatiotemporal Patterns Of Covid-19 In Japan From 2020 Through 2023, Atsuna Tokumoto, Kazuaki Jindai, Tomoki Nakaya, Mayuko Saito, Clive E Sabel, Hitoshi Oshitani

School of Geography, Earth and Environmental Sciences

BACKGROUND: The spread of coronavirus disease 2019 (COVID-19) varied among countries. The spatiotemporal trends of COVID-19 in Japan remain understudied. Therefore, this study aimed to conduct a detailed investigation of the spatiotemporal evolution of infections/deaths across prefectures in Japan, to analyze the changing patterns of COVID-19 circulation in metropolitan and nonmetropolitan areas.

METHODS: We extracted data from nationally represented open-source data from January 15, 2020, to May 9, 2023, and we calculated the incidence rate of infection and the mortality. Further the ratios were obtained by dividing those rates in prefectural level by those in national level to make them …


Canopy Functional Trait Variation Across Earth’S Tropical Forests, Jesús Aguirre-Gutiérrez, Sophie Fauset, Sami W. Rifai, Xiongjie Deng, Hans Ter Steege, Eleanor Thomson, Jose Javier Corral-Rivas, Aretha Franklin Guimaraes, Sandra Muller, Joice Klipel, Angelica F. Resende, Göran Wallin, Carlos A. Joly, Katharine Abernethy, Stephen Adu-Bredu, Celice Alexandre Silva, Edmar Almeida De Oliveira, Danilo R. A. Almeida, Esteban Alvarez-Davila, Gregory P. Asner, Timothy R. Baker, Maíra Benchimol, Lisa Patrick Bentley, Erika Berenguer, Lilian Blanc, Damien Bonal, Kauane Bordin, Robson Borges De Lima, Sabine Both, Jaime Cabezas Duarte Jan 2025

Canopy Functional Trait Variation Across Earth’S Tropical Forests, Jesús Aguirre-Gutiérrez, Sophie Fauset, Sami W. Rifai, Xiongjie Deng, Hans Ter Steege, Eleanor Thomson, Jose Javier Corral-Rivas, Aretha Franklin Guimaraes, Sandra Muller, Joice Klipel, Angelica F. Resende, Göran Wallin, Carlos A. Joly, Katharine Abernethy, Stephen Adu-Bredu, Celice Alexandre Silva, Edmar Almeida De Oliveira, Danilo R. A. Almeida, Esteban Alvarez-Davila, Gregory P. Asner, Timothy R. Baker, Maíra Benchimol, Lisa Patrick Bentley, Erika Berenguer, Lilian Blanc, Damien Bonal, Kauane Bordin, Robson Borges De Lima, Sabine Both, Jaime Cabezas Duarte

School of Geography, Earth and Environmental Sciences

Tropical forest canopies are the biosphere’s most concentrated atmospheric interface for carbon, water and energy1,2. However, in most Earth System Models, the diverse and heterogeneous tropical forest biome is represented as a largely uniform ecosystem with either a singular or a small number of fixed canopy ecophysiological properties3. This situation arises, in part, from a lack of understanding about how and why the functional properties of tropical forest canopies vary geographically4. Here, by combining field-collected data from more than 1,800 vegetation plots and tree traits with satellite remote-sensing, terrain, climate and soil data, we predict variation across 13 morphological, structural …


Relationships Between Sediment Size Distribution And Microplastic Abundance And Characteristics Along The Strandline Of A Sandy Embayment (Whitsand, Southwest England), Oliver J. Fenn, Edward J. Walklett, Andrew Turner Jan 2025

Relationships Between Sediment Size Distribution And Microplastic Abundance And Characteristics Along The Strandline Of A Sandy Embayment (Whitsand, Southwest England), Oliver J. Fenn, Edward J. Walklett, Andrew Turner

School of Geography, Earth and Environmental Sciences

Beach sediments taken from 1 m2 areas of strandline across an embayment in southwest England (Whitsand) have been analysed for grain size distribution and elemental content. Large (1–5 mm) and small (< 1 mm) microplastics were isolated by sieving and flotation in NaBr solution, respectively, and characterised by size, shape, colour and polymeric makeup. Sediments displayed varying median diameters and degrees of sorting but distributions were always positively skewed. Concentrations of Fe, K, Mn and Ti were relatively invariant, but Ca concentrations exhibited heterogeneous distributions across the bay. Large microplastics were largely composed of polyolefin-based pre-production pellets, bio-beads and fragments whose numbers were correlated with each other. Positive and inverse relationships between beads and sediment skewness and sorting, respectively, suggests that deposition of this type of plastic is favoured where sediment is well-sorted and contains a high proportion of fine material. Small microplastics were dominated by fragments and fibres <200 μm in size composed of a broader array of polymers (including epoxy resin, polyetherimide and polyvinyl alcohol). Fibres exhibited an inverse relationship with bead and pellet abundance but there was no evidence of dependency on grain size distribution, and their presence is attributed to entrapment in interstitial spaces between sediment grains. Compositional differences between large (1–5 mm) and small (< 1 mm) microplastic fragments suggests they are derived from different sources, with the former coupled with pellet and bead deposition and the latter small enough to be retained in interstitial spaces with fibres. However, a positive relationship between mean (small) fragment size and median sediment diameter suggests that their retention is more constrained by interstitial space than fibres. The study provides evidence that microplastics of different size and shape behave differently but are, ultimately, related to or controlled by sediment size distribution in the coastal littoral zone.


Care‐Ful Encounters: A Case For Empathetic Youthful Encounters With Coastal Environments, Mark Holton Jan 2025

Care‐Ful Encounters: A Case For Empathetic Youthful Encounters With Coastal Environments, Mark Holton

School of Geography, Earth and Environmental Sciences

This paper extends discourse of environmental stewardship and coastal management by examining the intersecting and overlapping relationships between notions of care and encounter in generating and maintaining forms of environmental empathy among young people at various socio-spatial scales. Exploring ‘care-ful encounters’ matters in terms of developing new ways of understanding how the choreographies of care and self-care shape, and are shaped by, encounters with human and non-human others, and prompts critical engagement and reflection with care as felt and experienced, that could otherwise be considered as distanced and ‘over there‘. Two key contributions emerge – first, that the combined role …


The State Of Temperate Rainforest In South West England, Thomas Murphy, Katerina Chernyuk, Marcin Roszkowski, Shaun Lewin, Paul Lunt, James Buckley Jan 2025

The State Of Temperate Rainforest In South West England, Thomas Murphy, Katerina Chernyuk, Marcin Roszkowski, Shaun Lewin, Paul Lunt, James Buckley

School of Geography, Earth and Environmental Sciences

Temperate Rainforest is a biome of global significance which is rare and declining, yet supports endemic biodiversity and offers a range of co-benefits including carbon sequestration, natural flood management, climate moderation, and human well-being. The UK hosts a very large proportion of European bioclimatic space suitable for the development of Temperate Rainforest, yet very little of this woodland remains. In SW England, Temperate Rainforest habitat is mostly dominated by oak woodland (NVC communities W11 and W17) and occupies a broad but fragmented distribution across the region. SW temperate rainforest is exposed to a range of current and future threats and …


Salinity Controls On Steel Biocorrosion Relevant To The Disposal Of High-Level Radioactive Waste, M. N. Rose, C. Boothman, S. Shaw, K. Morris, D. L. Engelberg, M. T. Bailey, J. R. Lloyd Jan 2025

Salinity Controls On Steel Biocorrosion Relevant To The Disposal Of High-Level Radioactive Waste, M. N. Rose, C. Boothman, S. Shaw, K. Morris, D. L. Engelberg, M. T. Bailey, J. R. Lloyd

School of Geography, Earth and Environmental Sciences

In a geological disposal facility (GDF) for spent fuel and high-level radioactive waste, the canister serves as one of the main engineered barriers. The resistance of the canister to degradation processes such as microbially influenced corrosion (MIC) needs be characterised to support GDF environmental safety cases. Here the impacts of salinity on sulfate-reducing bacterial (SRB) activity and associated MIC were explored in 84-day batch incubations at 30 °C. A 5 % standard bentonite slurry (MX80) in a low-salinity (0.1 g l−1 NaCl) artificial groundwater containing lactate added as an electron donor provided suitable conditions for the proliferation of SRB. …


Patient-Reported Outcomes, Postoperative Pain And Pain Relief After Day Case Surgery (Poppy): Methodology For A Prospective, Multicentre Observational Study*, William M. Hare, Martha Belete, Adam B. Brayne, Harriet Daykin, Matthew Everson, Anna Ratcliffe, Katie Samuel, Lexy Sorrell, Mark Rockett Jan 2025

Patient-Reported Outcomes, Postoperative Pain And Pain Relief After Day Case Surgery (Poppy): Methodology For A Prospective, Multicentre Observational Study*, William M. Hare, Martha Belete, Adam B. Brayne, Harriet Daykin, Matthew Everson, Anna Ratcliffe, Katie Samuel, Lexy Sorrell, Mark Rockett

Peninsula Medical School

Background: In the UK, approximately 70% of surgical procedures are undertaken as day-cases. Little information exists about recovery from day-case surgery, yet international data highlights patients are at risk of developing significant longer-term health problems including chronic post-surgical pain and persistent postoperative opioid use. The Patient-reported Outcomes, Postoperative Pain and pain relief after daY case surgery (POPPY) study was a national prospective multicentre observational study, measuring short- and longer-term patient-reported outcomes, postoperative pain and pain relief after day-case surgery. Methods: This was a collaborative project led by resident anaesthetists under the Research and Audit Federation of Trainees umbrella. Adult day-case …


The Current Clinical Practice And Experiences In Buccal Midazolam Prescribing In Community For Status Epilepticus Termination In The United Kingdom: The Rescue Epilepsy Medication And Training (Remit) Study, Rohit Shankar Jan 2025

The Current Clinical Practice And Experiences In Buccal Midazolam Prescribing In Community For Status Epilepticus Termination In The United Kingdom: The Rescue Epilepsy Medication And Training (Remit) Study, Rohit Shankar

Peninsula Medical School

Background: Epilepsy is one of the commonest neurological conditions worldwide and confers a significant mortality risk, partly driven by status epilepticus (SE). Terminating SE is the goal of pharmaceutical rescue therapies. This survey evaluates UK-based healthcare professionals’ clinical practice and experience in community-based rescue therapy prescribing. Methods: A cross-sectional, 21 item questionnaire composed of Likert-style and free-text based questions was administered online. It was distributed through a non-discriminative snow-balling methodology to members of the Epilepsy Specialist Nurses’ Association (ESNA) and the British International League Against Epilepsy (ILAE). Quantitative analysis used Chi-squared, Fishers’ exact and Mann-Whitney tests. Qualitative data were analysed …


Field Learning And Employability In Geography, Earth, And Environmental Sciences, Jacqueline Dohaney, Alison Stokes Jan 2025

Field Learning And Employability In Geography, Earth, And Environmental Sciences, Jacqueline Dohaney, Alison Stokes

School of Geography, Earth and Environmental Sciences

Society needs talented Geography, Earth and Environmental Sciences (GEES) graduates to help address global challenges, but the pathway to professional employment is seldom easy. After graduation, most GEES graduates enter professions requiring broad transferable skills and 'value-added' experiences to thrive in the modern workforce. GEES educators can therefore enhance employability by using field experiences to introduce and develop transferable skills valued by employers. Here, we define employability for our context, explore GEES graduate skills and describe the ways that communication, project management and personal and professional skills can be embedded in field experiences guided by the available literature. We identify …


Conservation Planning For Promoting Ecosystem Service Provisioning Outside Protected Area Networks, Florence Godfrey Tarimo, Francis Moyo, Claire Kelly, Linus Kasian Munishi Jan 2025

Conservation Planning For Promoting Ecosystem Service Provisioning Outside Protected Area Networks, Florence Godfrey Tarimo, Francis Moyo, Claire Kelly, Linus Kasian Munishi

School of Geography, Earth and Environmental Sciences

Among factors that contribute to global biodiversity loss, habitat loss through unsustainable land use and land cover changes has gained prominence, with impacts being exacerbated by increasing human populations. Establishing protected area networks (PANs) is strongly advocated by national and international mechanisms, such as the Convention on Biological Diversity (CBD), as a primary strategy to guide biodiversity conservation and management; however, this can undermine conservation efforts outside protected areas. Understanding how people and biodiversity overlap and interact outside protected area networks (OPAN areas) is essential for setting realistic, sustainable targets to guide biodiversity conservation and ecosystem service provision beyond PAN. …


Arctic Fjord Ecosystem Adaptation To Cryosphere Meltdown Over The Past 14,000 Years, Jochen Knies, Youngkyu Ahn, Berenice Ebner, Lukas Smik, Kwangchul Jang, Seung Il Nam, Simon T. Belt, Carsten J. Schubert Jan 2025

Arctic Fjord Ecosystem Adaptation To Cryosphere Meltdown Over The Past 14,000 Years, Jochen Knies, Youngkyu Ahn, Berenice Ebner, Lukas Smik, Kwangchul Jang, Seung Il Nam, Simon T. Belt, Carsten J. Schubert

School of Geography, Earth and Environmental Sciences

The Arctic cryosphere is the epicentre of acute global change impact, with abrupt warming and amplification driving rapid sea ice decline and irreversible glacial ice loss. A key challenge is understanding how the cryosphere meltdown will impact Arctic marine carbon cycles and ecosystems. Here, we use organic geochemical biomarkers to trace the contribution of different planktonic groups to organic carbon in Arctic fjord sediments (Kongsfjorden, Svalbard) during past warmer and colder (than present) climate states. We show that phytoplankton community structures changed abruptly with variable sea ice cover and glacial ice loss. Our results imply that future deglaciation of Svalbard …


Analytical Inconsistencies In The Measurement And Reporting Of Ip25, Ipso25 And Related Biomarkers For Paleo Sea Ice Reconstruction, Simon T. Belt, Lukas Smik Jan 2025

Analytical Inconsistencies In The Measurement And Reporting Of Ip25, Ipso25 And Related Biomarkers For Paleo Sea Ice Reconstruction, Simon T. Belt, Lukas Smik

School of Geography, Earth and Environmental Sciences

IP25 and related biomarkers are commonly used for Arctic and Antarctic sea ice reconstruction. With a growing number of laboratories performing their measurement, we reviewed many publications spanning the period 2007–2024 in order to assess analytical rigour. We found a number of common shortfalls in analytical protocols, or at least how they are reported, which may have important implications for future synthesis studies and meta-data analyses. Here, we outline some of these shortcomings and provide suggestions of how to improve both data acquisition and reporting.


Elevated Co2 Increases The Canopy Temperature Of Mature Quercus Robur (Pedunculate Oak), William Hagan Brown, Emanuel Gloor, Ralph Fyfe, A. Rob Mackenzie, Nicholas J. Harper, Peter Ganderton, Kris Hart, Giulio Curioni, Susan Quick, Scott J. Davidson, Emily Yetton, Jen L. Diehl, Sophie Fauset Jan 2025

Elevated Co2 Increases The Canopy Temperature Of Mature Quercus Robur (Pedunculate Oak), William Hagan Brown, Emanuel Gloor, Ralph Fyfe, A. Rob Mackenzie, Nicholas J. Harper, Peter Ganderton, Kris Hart, Giulio Curioni, Susan Quick, Scott J. Davidson, Emily Yetton, Jen L. Diehl, Sophie Fauset

School of Geography, Earth and Environmental Sciences

The canopy thermal response of natural forests to elevated CO2 (eCO2) is an understudied biophysical feedback in the global climate system. We investigated the effects of eCO2 (150 μmol mol−1 above ambient) on canopy temperature (Tcan) dynamics of mature (> 175 years) Quercus robur (oak) at the Birmingham Institute for Forest Research Free Air CO2 Enrichment (BIFoR-FACE) facility in Staffordshire, England, during the growing seasons of 2021, 2022 and 2023. We employed long-term, high-frequency thermal infrared (TIR) imaging to measure Tcan. Our results show that daily maximum oak Tcan …


Tolerance Of Ambiguity And Psychological Wellbeing In Newly Qualified Doctors: An Analysis Over Multiple Time Points, Tom Gale Jan 2025

Tolerance Of Ambiguity And Psychological Wellbeing In Newly Qualified Doctors: An Analysis Over Multiple Time Points, Tom Gale

Peninsula Medical School

Introduction: There is evidence of an association between tolerance of ambiguity and psychological wellbeing in doctors, but this relationship is not well understood. We explored this relationship, and the individual or workplace factors moderating it, in a population of newly qualified doctors. Methods: We examined the experiences of newly qualified doctors in the UK as they started a novel interim role (Time 1) and later moved into foundation year 1 roles (Times 2 and 3) during the COVID-19 pandemic. Doctors completed the Tolerance of Ambiguity of Medical Students and Doctors scale (TAMSAD Range: 0–100), the Perceived Stress Scale (PSS: 0–40), …


Systematic Review Of Paediatric Sudep And Epilepsy-Related Deaths To Inform A Safety Counselling Checklist For Clinical Practice, Rohit Shankar Jan 2025

Systematic Review Of Paediatric Sudep And Epilepsy-Related Deaths To Inform A Safety Counselling Checklist For Clinical Practice, Rohit Shankar

Peninsula Medical School

BackgroundOne in 200 children - in the UK have epilepsy. Approximately, 1 in 1,000 children with epilepsy die yearly from Sudden unexpected death in epilepsy (SUDEP), a leading cause of death in epilepsy. Various risk factors contributing to epilepsy mortality particularly SUDEP, some modifiable, have been identified. Structured discussion of risks results in behavioural change that reduces individual risk factors.AimTo investigate and collate risk factors for SUDEP and epilepsy mortality in children to propose a structured communication tool (“Checklist”) for person centred communication.MethodsA Systematic review for children’s epilepsy mortality risk factors was conducted. The search strategy was developed by clinical …


Patterns Of Intra-Cluster Correlation Coefficients In School-Based Cluster Randomised Controlled Trials Of Interventions For Improving Social-Emotional Functioning Outcomes In Pupils: A Secondary Data Analysis Of Five Uk-Based Studies, Kitty Parker, Michael Nunns, Zhi Min Xiao, Tamsin Ford, Paul Stallard, Willem Kuyken, Nick Axford, Obioha C. Ukoumunne Jan 2025

Patterns Of Intra-Cluster Correlation Coefficients In School-Based Cluster Randomised Controlled Trials Of Interventions For Improving Social-Emotional Functioning Outcomes In Pupils: A Secondary Data Analysis Of Five Uk-Based Studies, Kitty Parker, Michael Nunns, Zhi Min Xiao, Tamsin Ford, Paul Stallard, Willem Kuyken, Nick Axford, Obioha C. Ukoumunne

Peninsula Medical School

Background: The cluster randomised trial (CRT) design is increasingly used to evaluate the impact of school-based interventions for improving social-emotional functioning outcomes in pupils. Good knowledge is required on plausible values of the intra-cluster correlation coefficient (ICC) of the outcome to calculate the required sample size in such studies. Using data from five school-based CRTs in the UK, we estimate, and describe patterns in, ICCs for social-emotional functioning outcomes. Methods: Mixed effects linear regression models were fitted to estimate the ICC and variance components. Estimates for baseline data were obtained by fitting “null” models that had no predictor variables; estimates …


Evidence For Alcohol-Mediated Hemolysis And Erythrophagocytosis, Chaowen Zheng, Siyuan Li, Johannes Mueller, Cheng Chen, Huanran Lyu, Guandou Yuan, Ane Zamalloa, Lissette Adofina, Parthi Srinivasan, Krishna Menon, Nigel Heaton, Stephan Immenschuh, Ines Silva, Vanessa Rausch, Seddik Hammad, Steven Dooley, Shilpa Chokshi, Antonio Riva, Songqing He, Sebastian Mueller Jan 2025

Evidence For Alcohol-Mediated Hemolysis And Erythrophagocytosis, Chaowen Zheng, Siyuan Li, Johannes Mueller, Cheng Chen, Huanran Lyu, Guandou Yuan, Ane Zamalloa, Lissette Adofina, Parthi Srinivasan, Krishna Menon, Nigel Heaton, Stephan Immenschuh, Ines Silva, Vanessa Rausch, Seddik Hammad, Steven Dooley, Shilpa Chokshi, Antonio Riva, Songqing He, Sebastian Mueller

Peninsula Medical School

Alcohol-related liver disease (ALD) is the most common liver disease worldwide; however, its underlying molecular mechanisms remain poorly understood. Here, we identify ethanol-mediated hemolysis and erythrophagocytosis as major contributors to ALD pathogenesis using both in vitro and in vivo models, as well as surrogate markers such as heme oxygenase-1 (HO-1) and CD163, a scavenger receptor for hemoglobin-haptoglobin complexes. A key initial observation was the direct optical evidence of serum hemolysis in heavy drinkers, which diminished after one week of alcohol withdrawal. In parallel, soluble CD163 (sCD163) levels declined during alcohol detoxification correlating with liver damage and fibrosis stages. Moreover, red …


Productivity History Of The Central Okhotsk Sea And Northeast Russia During The Mid-Pleistocene Transition, Li Lo, Wei Zhu Chen, Julie Lattaud, Yi Hsueh Tsai, Simon T. Belt, Lukas Smik, Yuen Tung Kiki Wan Jan 2025

Productivity History Of The Central Okhotsk Sea And Northeast Russia During The Mid-Pleistocene Transition, Li Lo, Wei Zhu Chen, Julie Lattaud, Yi Hsueh Tsai, Simon T. Belt, Lukas Smik, Yuen Tung Kiki Wan

School of Geography, Earth and Environmental Sciences

Biological productivity, shaped by climate and environmental factors, is critical to climate feedback mechanisms and the global carbon cycle. This study investigates the measurement of six phytosterols (β-sitosterol, stigmasterol, campesterol, dinosterol, epi-brassicasterol, and 24-methylene cholesterol) from core MD01-2414 in the central Okhotsk Sea, covering the past 1.5 million years (Ma). These sterols serve as proxies for terrestrial and marine productivity in the central Okhotsk Sea and northeast Siberia. Sterol concentrations reflect global glacial/interglacial cycles between 1.2 and 0.6 Ma, with higher and lower values during interglacial and glacials intervals, respectively. X-ray fluorescence (Ba/Ti) and total organic carbon/total nitrogen (TOC/TN) ratios …


How Epilepsy Risks Might Be Introduced And Discussed In Clinical Consultations, Rohit Shankar Jan 2025

How Epilepsy Risks Might Be Introduced And Discussed In Clinical Consultations, Rohit Shankar

Peninsula Medical School

AbstractAdverse impacts of epilepsy (e.g., injury, depression, and Sudden Unexpected Death from Epilepsy (SUDEP) can be mitigated by factors that patients may control, such as medication adherence, improved sleep and diet, reduced alcohol and taking care around pregnancy. New guidelines state that risk should be discussed at the time of diagnosis but some clinicians express concern about not wanting to raise anxiety.ObjectiveTo explicate practices by which epilepsy expert clinicians broach discussions of risk in specialist epilepsy clinics.Methods24 recordings of initial telephone appointments at specialist clinics where epilepsy is diagnosed from two specialist outpatient epilepsy services in England were subjected to …


Il-1 Signal Inhibition In Alcohol-Related Hepatitis: A Randomized, Double-Blind, Placebo-Controlled Trial Of Canakinumab, Nikhil Vergis, Vishal Patel, Karolina Bogdanowicz, Justyna Czyzewska-Khan, Rosemary Keshinro, Francesca Fiorentino, Emily Day, Paul Middleton, Stephen Atkinson, Thomas Tranah, Mary Cross, Daphne Babalis, Neil Foster, Emma Lord, Alberto Quaglia, Josephine Lloyd, Robert Goldin, William Rosenberg, Richard Parker, Paul Richardson, Steven Masson, Gavin Whitehouse, Cyril Sieberhagan, David Patch, Nikolai Naoumov, Ashwin Dhanda, Ewan Forrest, Mark Thursz Jan 2025

Il-1 Signal Inhibition In Alcohol-Related Hepatitis: A Randomized, Double-Blind, Placebo-Controlled Trial Of Canakinumab, Nikhil Vergis, Vishal Patel, Karolina Bogdanowicz, Justyna Czyzewska-Khan, Rosemary Keshinro, Francesca Fiorentino, Emily Day, Paul Middleton, Stephen Atkinson, Thomas Tranah, Mary Cross, Daphne Babalis, Neil Foster, Emma Lord, Alberto Quaglia, Josephine Lloyd, Robert Goldin, William Rosenberg, Richard Parker, Paul Richardson, Steven Masson, Gavin Whitehouse, Cyril Sieberhagan, David Patch, Nikolai Naoumov, Ashwin Dhanda, Ewan Forrest, Mark Thursz

Peninsula Medical School

Background and Aims: Short-term mortality in alcohol-related hepatitis (AH) is high, and no current therapy results in durable benefit. A role for interleukin (IL)-1β has been demonstrated in the pathogenesis of alcohol-induced steatohepatitis. This study explored the safety and efficacy of canakinumab (CAN), a monoclonal antibody targeting IL-1β, in the treatment of patients with AH. Methods: Participants with biopsy-confirmed AH and discriminant function ≥32 but Model for End-Stage Liver Disease ≤27 were randomly allocated 1:1 to receive either CAN 3 mg/kg or placebo (PBO). Liver biopsies were taken before and 28 days after treatment. The primary endpoint was the overall …


A Mapping Review Of Studies Exploring The Barriers And Facilitators To A Dementia Diagnosis Through An Intersectionality Lens, Ben Hicks, Katherine Wheatley, Emma Porter, Nicolas Farina, Sube Banerjee Jan 2025

A Mapping Review Of Studies Exploring The Barriers And Facilitators To A Dementia Diagnosis Through An Intersectionality Lens, Ben Hicks, Katherine Wheatley, Emma Porter, Nicolas Farina, Sube Banerjee

Peninsula Medical School

BackgroundPromoting a ‘timely’ diagnosis is a global policy directive.AimsThis review adopts an intersectional approach, visually mapping the existing literature to highlight gaps in the evidence base on barriers and facilitators to dementia diagnosis.MethodA systematic approach was undertaken, following the PRISMA guidelines, updating previous reviews. The literature search was conducted on PubMed, PsycINFO, CINAHL Complete and Scopus. In line with mapping review methodology, we report the current state of the literature by describing the number of studies that outline barriers and facilitators to seeking help for a dementia diagnosis, split by social categorisation.ResultsOn the 7 June 2024, a total of 45 …


From Hospital Discharge To Long-Term Care: Unmet Rehabilitation Needs In Cauda Equina Syndrome Patients From A National Uk Cohort, Uces Collaborators, British Neurosurgical Trainee Research Collaborative, Holly Roy, Krithika Anil, Jack Read, Marcus J. Drake, Ingrid Hoeritzauer, Julie Woodfield Jan 2025

From Hospital Discharge To Long-Term Care: Unmet Rehabilitation Needs In Cauda Equina Syndrome Patients From A National Uk Cohort, Uces Collaborators, British Neurosurgical Trainee Research Collaborative, Holly Roy, Krithika Anil, Jack Read, Marcus J. Drake, Ingrid Hoeritzauer, Julie Woodfield

Peninsula Medical School

Objectives: Although long term disability may be a consequence of cauda equina syndrome (CES), the evidence base for the effect of rehabilitation or different rehabilitation strategies is lacking. Our aim was to understand long term neurological deficits (understood as rehabilitation needs) and current rehabilitation provision for patients with CES. Methods: We retrospectively analysed data from a large UK wide cohort of CES patients presenting between 1st June 2018 and 31st May 2019. Rehabilitation referrals and attendance were described, and symptoms at discharge and one year were identified as potential targets for rehabilitation. Results: Physiotherapy was the most common inpatient rehabilitation …


Autolyzed Brewer's Yeast Enhances Growth And Intestinal Health In Early Life Stages Of Nile Tilapia (Oreochromis Niloticus L.), Sheu Odu-Onikosi, Taofik Momoh, Ben Eynon, Nicola Pontefract, Victor Kuri, Holger Kühlwein, Daniel Merrifield Jan 2025

Autolyzed Brewer's Yeast Enhances Growth And Intestinal Health In Early Life Stages Of Nile Tilapia (Oreochromis Niloticus L.), Sheu Odu-Onikosi, Taofik Momoh, Ben Eynon, Nicola Pontefract, Victor Kuri, Holger Kühlwein, Daniel Merrifield

School of Biological and Marine Sciences

The early life stages of fish are critical for determining the overall productivity and sustainability of aquaculture operations. This study investigated the effects of dietary autolyzed brewer's yeast (ABY) on the growth performance and intestinal health of Nile tilapia fry (Oreochromis niloticus). A 35-day feeding trial with 480 Nile tilapia fry across 12 experimental tanks tested the effects of diets supplemented with 1, 2, and 4 g/kg of ABY, with a control diet for comparison. The results indicated that the diet which had 1 g/kg ABY supplementation (ABY1) significantly enhanced the weight gain and specific growth rate (SGR) while reducing …


Predicting Dune Evolution On A Regional Scale For Coastal Management, Liane M. Brodie, C. Stokes, G. Masselink, A. Konstantinou, T. Scott, T. Poate Jan 2025

Predicting Dune Evolution On A Regional Scale For Coastal Management, Liane M. Brodie, C. Stokes, G. Masselink, A. Konstantinou, T. Scott, T. Poate

School of Biological and Marine Sciences

Dunes provide a range of ecosystem services, including natural resilience against coastal flooding, and it is essential for proactive coastal zone management to forecast future dune behaviour as sea levels rise. However, dunes exhibit dynamic behaviours over a wide range of spatial and temporal scales, posing challenges for predicting their evolution. Here we demonstrate a high degree of variability in contemporary dune behaviour along a single coastal region, across 31 sites in Cornwall, southwest England. Rates of change varied widely, with sediment loss ranging from −12.4 m³/m/yr to a gain of +5.1 m³/m/yr, and dune retreat/advancement ranging from −3.7 m/yr …


The Impact Of Led Light Spectra On The Growth, Yield, Physiology, And Sweetness Compound Of Stevia Rebaudiana, Naofel Aljafer, Abdullah Alrajhi, Toby Anderson Von Trampe, William Vevers, Sophie Fauset, Hail Zuhir Rihan Jan 2025

The Impact Of Led Light Spectra On The Growth, Yield, Physiology, And Sweetness Compound Of Stevia Rebaudiana, Naofel Aljafer, Abdullah Alrajhi, Toby Anderson Von Trampe, William Vevers, Sophie Fauset, Hail Zuhir Rihan

School of Biological and Marine Sciences

This study investigated the effects of several light spectra on Stevia rebaudiana, analysing growth parameters, yield, and physiological responses within a controlled-environment agriculture (CEA) system. The experimental design involved different light treatments, including specific combinations of blue (435 nm and 450 nm), red (663 nm), and ultraviolet (UV) wavelengths (365 nm), to determine their impact on morphological development and biochemical properties, particularly focusing on the production of the sweetening compounds stevioside and rebaudioside A. Stevia rebaudiana plants cultivated from cuttings sourced from a reputable UK nursery (Gardener’s Dream Ltd., Glasgow, UK) were subjected to these spectral treatments over a period …


Shifting Attention: Assessing Antennular ‘Gaze’ In The Hermit Crab Pagurus Bernhardus, Ari Drummond, John Spicer, Lucy Turner, Alexander Wilson, Mark Briffa Jan 2025

Shifting Attention: Assessing Antennular ‘Gaze’ In The Hermit Crab Pagurus Bernhardus, Ari Drummond, John Spicer, Lucy Turner, Alexander Wilson, Mark Briffa

School of Biological and Marine Sciences

Attention (focused information gathering) is crucial for many cognitive processes. Traditionally dichotomised as reflexive or voluntary, behavioural research often relies on vision for assessments of attention. However, invertebrate information acquisition often utilises chemosensation or mechanosensation, potentially limiting the efficacy of a vision-based approach. We examined attention in Pagurus bernhardus hermit crabs, using antennules (the crustacean first antennae) as indicators of attentional shifts. Considering a change in flicking direction as analogous to a shift in gaze, we examined if hermit crabs show evidence of reflexive or voluntary attention. We exposed crabs to a chemosensory stimulus while manipulating factors influencing vulnerability (i.e., …


Ecotoxicological Effects Of Sunscreen Derived Organic And Inorganic Uv Filters On Marine Organisms: A Critical Review, Anneliese A. Hodge, Frances E. Hopkins, Mahasweta Saha, Awadhesh N. Jha Jan 2025

Ecotoxicological Effects Of Sunscreen Derived Organic And Inorganic Uv Filters On Marine Organisms: A Critical Review, Anneliese A. Hodge, Frances E. Hopkins, Mahasweta Saha, Awadhesh N. Jha

School of Biological and Marine Sciences

Sunscreens are topical personal care products that provide protection against the sun's ultraviolet A (UVA) and ultraviolet B (UVB) radiation. Ultraviolet (UV) filters are compounds added to sunscreens to block, absorb, or reflect the sun's UV rays, but are of major emerging concern due to their widespread use and global distribution. They pose a significant risk to marine organisms owing to their chemical properties, including high lipophilicity which increases their bioavailability. The present review identifies and summarises the factors that contribute to UV filter pollution, their sources, pathways, and effects on marine organisms. We identify and evaluate the current knowledge …


Is Sparse Local Ecological Knowledge Accurate Enough For Policy? A Seagrass Mapping Case Study From Five Greek Islands In The Eastern Aegean Sea, Konstantis Alexopoulos, Tim J. Grandjean, Anastasia Miliou, Theodoros Tsimpidis, Abigail Mcquatters-Gollop Jan 2025

Is Sparse Local Ecological Knowledge Accurate Enough For Policy? A Seagrass Mapping Case Study From Five Greek Islands In The Eastern Aegean Sea, Konstantis Alexopoulos, Tim J. Grandjean, Anastasia Miliou, Theodoros Tsimpidis, Abigail Mcquatters-Gollop

School of Biological and Marine Sciences

The low cost, high applicability and community-based nature of Local Ecological Knowledge (LEK) data for mapping marine benthic habitats has become increasingly popular in recent years. Nonetheless, due to persisting technocratic distrust of LEK often stemming from the unquantifiable nature of bias, the embedding of empirical data at policy levels often lags. Currently, protocols rely on high participation from stakeholders, however, such quotas are often unfeasible, with common limiting factors being the low numbers of knowledgeable individuals in remote parts of the world, and the lack of community trust in the conservation mechanism. In this study, we test whether data …