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The Future Of Personalized Medicine In Saudi Arabia: Opportunities And Challenges, Wedad A. Mawkili

Saudi Medical Journal

Personalized medicine is a healthcare approach that designs treatment plans of each patient, considering genetic, environmental, and lifestyle factors. This model leverages genomic information, advanced diagnostics, and data analytics to predict disease risk, optimize prevention strategies, and provide customized treatments. In Saudi Arabia, personalized medicine is gaining momentum, driven by the country’s Vision 2030 initiative, which aims to transform the healthcare sector by integrating advanced medical technologies and improving healthcare delivery. The Kingdom has made significant strides in genomics and bioinformatics, with initiatives such as the Saudi Human Genome Program and advancements in institutions i.e., King Faisal Specialist Hospital and …

Development And Validation Of A Nomogram To Predict Survival After Neoadjuvant Chemotherapy In Elderly Women With Triple-Negative Invasive Ductal Breast Cancer: A Seer Population-Based Study, Ying Gao, Jinmiao Wang, Shoujun Wang, Weijie Tao, Ran Duan, Jie Hao, Ming Gao

Saudi Medical Journal

Objectives: To construct and verify a nomogram for post-neoadjuvant chemotherapy survival predication in elderly women with triple-negative invasive ductal breast cancer. Methods: Elderly patients diagnosed as triple-negative invasive ductal breast cancer between 2019-2000 were screened from surveillance, epidemiology, and end results database. Depending on the post-neoadjuvant chemotherapy pathological response, they were assigned to the complete or non-complete response group. Inter-group clinicopathological characteristics and disease-specific and overall survivals were compared. Then, they were allocated randomly into the training or validation cohort. A prediction nomogram was developed in the training cohort and verified in the validation cohort. Results: A total of 382 …

Body Shape Concerns, Sexual Satisfaction, And Associated Factors Among Patients With Polycystic Ovarian Syndrome: A Cross-Sectional Study In Western Saudi Arabia, Aseel A. Alsaidan, Ashokkumar Thirunavukkarasu, Hani H. Alsulami

Saudi Medical Journal

Objectives: To determine body shape concerns (BSCs), sexual satisfaction, and associated factors in patients with polycystic ovarian syndrome (PCOS). Methods: Using a structured and validated questionnaire, a cross-sectional survey was carried out at the Maternity and Children’s Hospital in Makkah, Saudi Arabia. Data were collected between August 2023 and June 2024. We included adult patients with PCOS who had completed at least one follow-up visit. We used multivariate analysis to determine the factors associated with BSC and sexual function. Spearman’s correlation analysis was executed to assess the correlation concerning these 2 aspects. Results: Of the 432 patients studied, nearly half …

Predictors Of Hypoglycemia Among Children Admitted In The Emergency Pediatric Unit Of The University Of Maiduguri Teaching Hospital, Maiduguri, Nigeria, Ruqayyatu A. Imam, Hassan A. Elechi, Hauwa Y. Musa, Adamu I. Rabasa, Habiba B. Bakari

Saudi Medical Journal

Objectives: To determine the prevalence and pattern of hypoglycemia among children admitted to the Emergency Pediatric Unit (EPU) at the University of Maiduguri Teaching Hospital, Maiduguri, Nigeria. Methods: A cross-sectional study was conducted between February and September 2020. Blood glucose, along with other relevant laboratory investigations, was measured for each patient upon admission to the EPU using a point-of-care test glucometer (ACCU-CHEK with strips). Results: Of the 340 children recruited for the study, 54 patients had hypoglycemia (<2.2 mmol/L), giving a prevalence rate of 15.9%. Thirty-six (66.7%) of the children with hypoglycemia were under the age of 5 years (odds ratio [OR]: 6.218 [1.077–35.912], p =0.041) and 26 (48.1%) were severely underweight (OR: 3.692 [1.266–10.971], p =0.017). Factors such as not having eaten for at least 16 h, weakness, and coma at presentation all independently predicted hypoglycemia (OR: 5.696 [1.768–18.352], 6.556 [1.730–24.850], 9.479 [3.092–29.059], p =0.004, 0.006 and <0.001) respectively. Severe malaria was also independently related to hypoglycemia (OR: 2.720 [0.554–13.365], p =0.021). Conclusion: Hypoglycemia is a common occurrence among children admitted to the EPU. Factors such as being under five years old, in a coma, weakness, severe malaria, and prolonged fasting were all identified as independent predictors of hypoglycemia. Therefore, routine blood glucose monitoring of children admitted to the EPU, specifically those at higher risk, is recommended.

Per Se Non-Takings, Nestor M. Davidson, Timothy M. Mulvaney

Faculty Scholarship

In the discourse on the Takings Clause, disputes over methodology have long formed a kind of proxy war, with per se rules ordinarily underwriting strong constitutional protection for property rights and ad hoc standards more often vindicating public interests. At a moment when the Supreme Court is increasingly embracing the rules end of this rules–standards spectrum, this Article offers a novel perspective to challenge the conventional link between categorical reasoning and classical liberal conceptions of constitutional property.

To do so, the Article excavates a vast body of law denying takings liability through rule-like reasoning, an approach the Article calls per …

The Shadow Defendants, Mariam A. Hinds

Faculty Scholarship

Although the overrepresentation of men, specifically Black men and men of color, in the criminal legal system is well documented, the people who support these men, especially women, have garnered less attention. Women who are proximate to system-involved men—mothers, grandmothers, sisters, daughters, girlfriends, and wives—are invisible actors in the criminal legal system who perform critical tasks and provide essential support. They appear in court to demonstrate a person’s family and community ties, use their assets as collateral for bail, deposit money in commissary accounts, maintain social ties during imprisonment through letters and visits, and bear the burden of filling the …

Commentary On Capture, Redesign, Release: Market Structure Or Charter Structure In Vice Markets?, Zephyr Teachout

Faculty Scholarship

This essay evaluates Taparia and Buchanan’s proposal to address the social costs of addiction-driven industries through a “capture, redesign, release” framework, under which government would exercise eminent domain to acquire tobacco firms and restructure them as purpose-driven corporations. The commentary argues that, while innovative, the proposal raises serious constitutional and corporate law concerns. First, the reliance on eminent domain is vulnerable under the Takings Clause, particularly given the Roberts Court’s likely skepticism toward expansive readings of Kelo v. City of New London. Second, the plan to prohibit corporate marketing and lobbying as part of a redesigned charter would almost …

Promise And Limits Of Total Governance: A Response To Professors Gramitto Ricci And Greenwood, Atinuke O. Adediran

Faculty Scholarship

In their article, Total Governance, Professors Gramitto Ricci and Greenwood theorize about how to increase the power and influence of ordinary individual shareholders who do not have a lot of wealth. The total governance framework has some promise for increasing the influence of ordinary people in corporate governance. It also raises questions about treating corporate actors as monoliths: managers, boards of directors, shareholders, and stakeholders. This brief response, however, takes the position of a skeptic who recognizes the theoretical potential of the total governance framework while highlighting the shortcomings of the concept for corporate governance.

Federal Open Data As An Artificial Intelligence Resource, Erik Stallman, Aniket Kesari

Faculty Scholarship

In the 2010s, the open government data movement—a confluence of government transparency and open source advocacy—succeeded in making most federal data disclosed by default and free of restriction on downstream use. However, keen-eyed observers noted a “new ambiguity” in open government data policies.

Sharing The Tuna Platter: A Uniform System Of Assessment For Clinical Education, Melina Healey

Scholarly Works

Legal education’s current methods for the measurement of student achievement in clinics, and the measurement of a clinic course’s effectiveness, are often unsatisfying, unreliable, and incomplete. This article presents a methodology for uniform and integrated systems of assessment across clinical programs that can provide more reliable evaluation of student progress and achievement, and better feedback to clinical programs on their effectiveness. It also shares how Touro University Jacob D. Fuchsberg Law Center’s Clinical Program applied these strategies with both success and challenges.

A Conviction In Jeopardy: The Mysterious Case Against Scott Peterson, Jolie Bodner Zangari

Scholarly Works

No abstract provided.

App Assisted Depression Self-Management In Integrated Primary Care: A Pilot Study Exploring Patient And Provider Experiences, David J. Johnson, Margaret R. Emerson, Danae Dinkel, Robbin Thomas, Shinobu Watanabe-Galloway, Maria S. Mickles, Carli Culjat

Journal Articles: Epidemiology

The integrated primary care (IPC) setting is currently the de facto institution for accessing mental healthcare among underserved populations. However, many barriers exist for these populations when seeking regular and adequate mental healthcare, including provider availability and transportation challenges. This study piloted the incorporation of mindLAMP, a mHealth app, into IPC treatment to offer a low-resource intervention designed to improve and expand access to mental healthcare for underserved patients between face-to-face visits. This study gathered data from a sample of both behavioral health providers and patients (N = 6) in IPC settings to pilot the use of the mindLAMP app …

Schistosoma Haematobium Infection And Associated Risk Factors Among Pre-School Age Children In Gambella, Ethiopia, Tigist Mohammed, Abraham Degarege, Mulugeta Aemero, Abebe Animut, Yohannes Negash, Yirgalem Gebrehiwot, Berhanu Erko

Journal Articles: Epidemiology

Background

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Sars-Cov-2 Genomic Surveillance Using Self-Collected Saliva Specimens During Occupational Testing Programs, Andy T. Schnaubelt, David Brett-Major, Janet Williamson, Bailey Barcal, Julie Carstens, Ashley Peer, Michael R. Wiley, M. Jana Broadhurst

Journal Articles: Epidemiology

Continually emerging SARS-CoV-2 variants pose challenges to clinical and public health interventions, necessitating sustainable approaches to real-time variant monitoring. This case study describes an innovative SARS-CoV-2 screening and surveillance program that demonstrates the utility of sequencing-based variant monitoring using self-collected saliva specimens. We conducted saliva-based SARS-CoV-2 screening in occupational settings in Omaha, Nebraska from December 2021 through November 2022. 8,372 saliva specimens collected from 1,480 participants were tested for SARS-CoV-2 RNA by extraction-free PCR, with 334 positive samples referred for whole-genome sequencing analysis. Program utilization, quality metrics, and sequencing outputs were compared across sites. Specimen quality was high across program …

Quantifying The Public Health Impact Of Lyme Disease In Minnesota: A Simulation Analysis Of Reported And Unreported Cases, Kathleen Angell, M. Jana Broadhurst, Jianghu James Dong, Tzeyu L. Michaud, Abraham Degarege, Roberto Cortinas, David Brett-Major

Journal Articles: Epidemiology

Background: Lyme disease, the most common vector-borne disease in Minnesota, is estimated to be underreported by a factor of 10. Delayed diagnosis and misdiagnosis may lead to health complications and increased personal and societal costs. Environmental factors can help to predict high disease years, allowing for early intervention to decrease disease burden. Objective: To estimate the health and cost burdens of Lyme disease and the extent to which they could be diminished by public health intervention when high-incidence Lyme disease years are forecasted. Methods: We used 5 two-dimensional Monte Carlo simulations to estimate (1) average annual expected burden of Lyme …

Understanding The Pathogenesis Of Uveitis In Ebola Virus Disease Survivors: An Observational Cohort And Cross-Sectional Study Protocol For Clinical, Molecular Virologic And Immunologic Characterisation, Caleb D. Hartley, Susanne Linderman, Tolulope Fashina, Laura Ward, Carolyn Drews-Botsch, Catherine Pratt, Sanjana Kuthyar, Alcides Filho Fernandes, Ye Huang, Charlene Choo, Nam Nguyen, Jessica Carag, Jill Morgan, Colleen S. Kraft, Angela L. Hewlett, David Brett-Major, John S. Schieffelin, Robert F. Garry, Donald Grant, Grant A. Justin, Christopher D. Conrady, Justine R. Smith, Brent R. Hayek, Shiama Balendra, Nisha Acharya, Thuy Doan, Anais Legand, Pierre Formenty, Xiankun Zeng, Ibrahim Conteh, Matthew Jusu Vandy, Lloyd Harrison-Williams, Jalikatu Mustapha, Zikan Koroma, Michael R. Wiley, Ian Crozier, Jean-Claude Mwanza, Jessica G. Shantha, Rafi Ahmed, Steven Yeh, Smile And Evict-Vr Investigator Study Groups

Journal Articles: Epidemiology

INTRODUCTION: The 2013-2016 Western African outbreak of the Ebola virus disease (EVD), the largest recorded outbreak since the discovery of Ebola virus (EBOV) in 1976, destabilised local health systems and left thousands of survivors at risk for postacute sequelae, including vision-threatening uveitis. In an EVD survivor with severe panuveitis, the detection of persistent EBOV in the aqueous humour, long after clearance of acute viremia, focused clinical and research attention on the host-EBOV interaction in the unique terrain of ocular immune privilege. Despite the recognition that uveitis is common and consequential in EVD survivors, our understanding of pathogenesis is extremely limited, …

Hpv Vaccination In The U.S. Midwest: Barriers And Facilitators Of Initiation And Completion In Adolescents And Young Adults, Kristyne D. Mansilla Dubon, Edward S. Peters, Shinobu Watanabe-Galloway, Abraham Degarege

Journal Articles: Epidemiology

Background/Objectives: HPV vaccination uptake among adolescents and young adults in the US remains low, and coverage in the Midwest falls short of the Healthy People 2030 goal of 80%. Methods: A cross-sectional survey of adolescents and young adults was conducted to identify facilitators and barriers to HPV vaccination uptake among adolescents and young adults in the Midwest. Results: Out of 1306 individuals aged 13-26 years, 397 (30.4%) were fully vaccinated (2-3 doses), 124 (9.5%) had received one dose, 324 (24.8%) were unvaccinated, and 461 (35.3%) were unsure of their vaccination status. Awareness of HPV vaccines (OR: 2.4, …

Courtly And Queer: Deconstruction, Desire, And Medieval French Literature, By Charlie Samuelson, Anna Klosowska

Medieval Feminist Forum: A Journal of Gender and Sexuality

No abstract provided.

Nascere. Il Parto Dalla Tarda Antichità All’Età Moderna Edited By Alessandra Foscati, Costanza Gislon Dopfel, And Antonella Parmeggiani, Marjolaine Raguin

Medieval Feminist Forum: A Journal of Gender and Sexuality

No abstract provided.

Women And Medieval Literary Culture: From The Early Middle Ages To The Fifteenth Century Edited By Corinne Saunders And Dianne Watt, Melissa Elmes

Medieval Feminist Forum: A Journal of Gender and Sexuality

No abstract provided.

The Fiduciary Code Of Capital And Climate Change, Seth Davis, Gregory Shaffer

Georgetown Law Faculty Publications and Other Works

Fiduciary law is part of the “code” for the management of capital, as Katharina Pistor has conceptualized law. Climate activists, attorneys, investors, and international organisations have turned to fiduciary law for legal solutions to the ongoing problem of inadequate corporate and state action in response to climate change. Our thesis is that the turn to fiduciary law by norm entrepreneurs is an attempt to encode a concern for climate change within the management of capital. We make two contributions to the literature on private law and climate change. First, we rigorously identify the features of fiduciary law that make it …

Revisiting Patent Linkage, John R. Thomas

Georgetown Law Faculty Publications and Other Works

Alfred Engelberg’s article of a quarter-century ago, Special Patent Provisions for Pharmaceuticals: Have They Outlived Their Usefulness?, raised a provocative question that retains currency today. The special provisions that Hatch-Waxman established, and Engelberg addressed, have come to be known as patent linkage. Following the principle of linkage, the Food and Drug Administration (FDA) cannot approve generic drugs for marketing if they would infringe a patent.

Hatch-Waxman’s complex patent provisions aspire towards multiple salutary purposes, including encouraging the prompt availability of generic drugs, improving public notice of pharmaceutical patents, and accelerating dispute resolution proceedings. Congress also attempted to ameliorate perceived …

Proximity And Density Of Tobacco Retail Locations To Kentucky Schools And The Relationship To Youth Perceptions Of Harm And Susceptibility To E-Cigarette Use, Hannah Cardona

Theses and Dissertations--Kinesiology and Health Promotion

Purpose: To explore the potential relationship between tobacco retailer proximity/density around Kentucky elementary, middle, and high schools, and students’ perceptions, perceived norms, susceptibility to, and use of e-cigarettes. Design: A mixed-methods analysis of youth’s self-reported survey results and geographical data. Setting: 106 Kentucky elementary, middle, and high schools which participated in #iCANendthetrend’s tobacco education program between September 2023 and May 2024. Subjects: Convenience sample of students from Ky schools (N = 7,823) Measures: Items assessing e-cigarette use, susceptibility, perceptions, and perceived norms. Analysis: ANOVA tests used to compare responses of elementary, middle, and high school students. Chi-squared tests were used …

Psychological Impacts In Exercise Riders And Professional Jockeys Following Injury, Kelley M. Renner

Theses and Dissertations--Kinesiology and Health Promotion

One of the most well-known equestrian sports, horse racing, is not only a cornerstone of Kentucky’s economy, but also a vital part of its culture, with professional jockeys playing an essential role in the local communities and traditions that define the state. Despite its popularity and financial impact, mental health challenges within the sport have continually been shrouded in silence and ignored in research (Ball et al., 2007). Equally concerning is the high injury prevalence, and psychological impact of these injuries (e.g., psychological distress, depression, anxiety, loss of identity, and self-esteem (King et al., 2022; Losty et al., 2019; McConn-Palfreyman …

Bridging Awareness And Access: Outdoor Recreation And Physical Activity In Eastern Kentucky, Timothy Mckay

Theses and Dissertations--Kinesiology and Health Promotion

Physical inactivity remains a pressing challenge in Appalachian Kentucky, where high obesity rates intersect with limited access to structured exercise facilities. This dissertation investigated the extent to which participation in outdoor recreation supports adherence to physical activity (PA) recommendations and explored community awareness of local public lands. Surveys from 52 adult participants in Knox County revealed strong engagement in outdoor activity, with participation significantly predicting compliance with national PA guidelines. Educational attainment was also associated with higher rates of PA compliance, pointing to the influence of literacy and awareness in health behaviors. Reliability testing of the Outdoor Physical Activity Attitude …

Exploring College Students’ Motivation For Physical Activity: Applications Of Self-Determination Theory And The Role Of Health And Wellness Education, Anne Russell Blevins

Theses and Dissertations--Kinesiology and Health Promotion

This dissertation includes three pieces of writing that aim to show the importance of physical activity for all ages but specifically college-aged students. The first piece of writing (Chapter 2) includes a teaching tip written for the Journal of Physical Education, Recreation, and Dance. Research has shown that dance was a subject of the past and many teachers did not feel comfortable teaching it. This practical piece was written to help show K-12 physical education teachers effective ways to involve students in physical activity specifically through teaching dance, mainly through using the “Teaching Dance for Understanding” model.

The second section …

Ai Characterisations And Their Legal Implications, Jerrold Tsin Howe Soh

Research Collection Yong Pung How School Of Law

This chapter examines the difficult legal characterisation problems that artificially intelligent systems raise and explores how different characterisations of artificial intelligence (AI) shape practical legal outcomes. Three reasons are offered for the legal difficulty with characterising AI. First, answers to characterisation problems are inherently subjective and perspective-driven, particularly when the subject is an intangible technological system. Second, AI technology is especially difficult to define since the field typically proceeds on inexact anthropomorphic metaphors. Third, AI characterisation problems raise difficult sub-problems, particularly in determining how autonomous an AI system is. The chapter thus argues that a range of plausible AI characterisations …

Financial Regulation, Aurelio Gurrea-Martinez, Nydia Remolina Leon

Research Collection Yong Pung How School Of Law

No abstract provided.

The Effect Of Intraoperative Facet Joint Denervation In The Prophylaxis Of Back Pain After Spinal Fixation: A Randomized Prospective Controlled Single-Blind Study, Mohamed Ali Abbas, Ahmed Zaghlol, Ayman M Ismail, Hamdy Nabwi, Mohamed Ismail, Ahmed Sameh Nada, Mona Mokhtar, Ahmed Shaker Elakhras

Mansoura Medical Journal

Background: Failed back surgery syndrome (FBSS) remains a significant challenge after fixation procedures of the spine. The present research assessed the efficacy of intraoperative facet joint denervation in preventing postoperative back pain in individuals undergoing spinal fixation. Methods: A randomized retrospective controlled single-blind study was carried out on 70 patients requiring spinal fixation assigned to two equal groups: Group A: intraoperative facet joint denervation was performed, while Group B was a control group. Pain levels were evaluated utilizing the visual analog scale (VAS) for 7 days following surgery. Follow-up visits occurred at 2 weeks, 1, 3, and 6 months. The …

Urinary Kidney Injury Molecule-1 As A Biomarker For Detection Of Albuminuria And Retinopathy Among Patients With Type 2 Diabetes Mellitus, Amr Y. El Feky, Yehia M. Ghanem, Talaat A. Abdelaaty, Magdy M. Elbordeny, Rabab H. Neanaa

Mansoura Medical Journal

Background: Diabetic retinopathy (DR) and diabetic kidney disease (DKD) are prevalent microvascular complications of type 2 diabetes mellitus (T2DM). The objective of this study was to examine the potential relevance of urinary kidney injury molecule-1 (uKIM-1) as a marker of DKD and DR in cases who have T2DM. Methods: A cross-sectional study has been performed among 60 cases with T2DM. They were subdivided into 30 patients with albuminuria and 30 patients without albuminuria. Sociodemographic data, fundus examination, laboratory investigations involving fasting blood glucose (FBG), fasting insulin, HbA1c, HOMA-IR, lipid profile, creatinine, and urinary albumin to creatinine ratio (ACR) have been …